v2.2.0

• Test improvements (determinism + increased coverage)
• Sanitize calc_tm input (see issue #115)
• Modernize build system & release process (see issue #154)

v2.1.0

• Support for python 3.13
• Silence stderr output during ascii structure generation (issue #146)
• Updated default formamide concentration to match latest primer3web value + oligotm default (issue #140)

v2.0.3

• Clarify how to replace setGlobals as of v1.0.0 (#134)
• Fix _ThermoAnalysis._set_globals_and_seq_args for improper checks on misprime_lib and mishyb_lib (#135)

v2.0.2

• Support for python 3.12 (build, test, docs) (#129)
• Update cibuildwheel to latest release for python 3.12 build support (#131)

v2.0.1

• Fixed bug in todict method of ThermoAnalysis (#123)

v2.0.0

• Migrated primer3 header file Cython extern imports to thermoanalysis.pxi
• Optional C structure string argument c_ascii_structure added to _ThermoAnalysis methods to enable 3rd party use for structures
• Version bump to 2.0.0 due to breaking change
• Fix issue whereby no_structure is not correctly set to 1 when no secondary structure in found
• add list version of PRIMER_{PAIR, LEFT, RIGHT, INTERNAL} to design output dictionary keys. Retaining original keys as well for compatibility.
• Fix for missing thal_result.sec_struct and dpal_results.sec_struct initialization to NULL in recalc_primer_sec_struct

v1.2.2

• Bug fixes for output formatting related to penalty, "problem", and mispriming fields

v1.2.1

• Bug fixes for pdh_create_seq_lib to correct missing seq_lib datastructure allocation and variable name typos.
• Increase test coverage to include misprime_lib and mishyb_lib arguments

v1.2.0

• Threadsafe changes made to thal.c resulting in new thalflex.c and thalflex.h and thalflexsignatures.h.
• Threadsafe changes made to libprimer3.c resulting in new libprimer3flex.c and ibprimer3flex.c.h.
• libprimer3.seq_args datatype is now renamed to libprimer3.seq_args_t
• test_threadsafe.py add and nogil instituted for calls to thal() and seqtm() added run_design and calc_heterodimer threadsafe tests
• ThermoAnalysis class no longer needs to be a Singleton so this was removed as a parent class
• p3helpers.pyx houses new sequence and design helper functions
• setup.py package_data and MANIFEST.in to assist with future builds from tar.gz (conda)

v1.1.0

• Added specificity to error non-N IUPAC error for issue #59
• Wheel build support for python 3.8 to move towards following the CPython EOL model for issue #88. See https://devguide.python.org/versions/