diff --git a/compiler/rustc_target/src/spec/targets/wasm32v1_none.rs b/compiler/rustc_target/src/spec/targets/wasm32v1_none.rs
index e554e2ac07680..63a785a35b66c 100644
--- a/compiler/rustc_target/src/spec/targets/wasm32v1_none.rs
+++ b/compiler/rustc_target/src/spec/targets/wasm32v1_none.rs
@@ -29,6 +29,11 @@ pub(crate) fn target() -> Target {
             // For now this target just never has an entry symbol no matter the output
             // type, so unconditionally pass this.
             "--no-entry",
+            // It is also necessary to explicitly set CPU and features since some changes
+            // were made to WebAssembly starting with LLVM 20.1.0:
+            // https://releases.llvm.org/20.1.0/docs/ReleaseNotes.html#changes-to-the-webassembly-backend
+            "--mllvm=-mcpu=mvp",
+            "--mllvm=-mattr=+mutable-globals",
         ],
     );
     options.add_pre_link_args(
@@ -37,7 +42,7 @@ pub(crate) fn target() -> Target {
             // Make sure clang uses LLD as its linker and is configured appropriately
             // otherwise
             "--target=wasm32-unknown-unknown",
-            "-Wl,--no-entry",
+            "-Wl,--no-entry,--mllvm=-mcpu=mvp,--mllvm=-mattr=+mutable-globals",
         ],
     );