diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml
index 8f1fdab6c509..7c6accbbe433 100644
--- a/.github/workflows/ci.yml
+++ b/.github/workflows/ci.yml
@@ -29,7 +29,6 @@ jobs:
           - {VERSION: "3.12", NOXSESSION: "docs", OPENSSL: {TYPE: "openssl", VERSION: "3.5.3"}}
           - {VERSION: "3.14-dev", NOXSESSION: "tests"}
           - {VERSION: "3.14t-dev", NOXSESSION: "rust,tests"}
-          - {VERSION: "pypy-3.10", NOXSESSION: "tests-nocoverage"}
           - {VERSION: "pypy-3.11", NOXSESSION: "tests-nocoverage"}
           - {VERSION: "3.13", NOXSESSION: "tests", OPENSSL: {TYPE: "openssl", VERSION: "3.5.3", CONFIG_FLAGS: "no-engine no-rc2 no-srtp no-ct no-psk"}}
           - {VERSION: "3.13", NOXSESSION: "tests", OPENSSL: {TYPE: "openssl", VERSION: "3.5.3", CONFIG_FLAGS: "no-legacy", NO_LEGACY: "0"}}
diff --git a/.github/workflows/wheel-builder.yml b/.github/workflows/wheel-builder.yml
index 7cde388cab4f..ed9d81721afd 100644
--- a/.github/workflows/wheel-builder.yml
+++ b/.github/workflows/wheel-builder.yml
@@ -69,7 +69,6 @@ jobs:
           - { VERSION: "cp311-cp311", ABI_VERSION: 'py38' }
           - { VERSION: "cp311-cp311", ABI_VERSION: 'py311' }
           - { VERSION: "cp314-cp314t" }
-          - { VERSION: "pp310-pypy310_pp73" }
           - { VERSION: "pp311-pypy311_pp73" }
         MANYLINUX:
           - { NAME: "manylinux2014_x86_64", CONTAINER: "cryptography-manylinux2014:x86_64", RUNNER: "ubuntu-latest" }
@@ -89,38 +88,24 @@ jobs:
 
         exclude:
           # There are no readily available musllinux PyPy distributions
-          - PYTHON: { VERSION: "pp310-pypy310_pp73" }
-            MANYLINUX: { NAME: "musllinux_1_2_x86_64", CONTAINER: "cryptography-musllinux_1_2:x86_64", RUNNER: "ubuntu-latest"}
-          - PYTHON: { VERSION: "pp310-pypy310_pp73" }
-            MANYLINUX: { NAME: "musllinux_1_2_aarch64", CONTAINER: "cryptography-musllinux_1_2:aarch64", RUNNER: "ubuntu-24.04-arm" }
           - PYTHON: { VERSION: "pp311-pypy311_pp73" }
             MANYLINUX: { NAME: "musllinux_1_2_x86_64", CONTAINER: "cryptography-musllinux_1_2:x86_64", RUNNER: "ubuntu-latest"}
           - PYTHON: { VERSION: "pp311-pypy311_pp73" }
             MANYLINUX: { NAME: "musllinux_1_2_aarch64", CONTAINER: "cryptography-musllinux_1_2:aarch64", RUNNER: "ubuntu-24.04-arm" }
 
             # We also don't build pypy wheels for anything except the latest manylinux
-          - PYTHON: { VERSION: "pp310-pypy310_pp73" }
-            MANYLINUX: { NAME: "manylinux2014_x86_64", CONTAINER: "cryptography-manylinux2014:x86_64", RUNNER: "ubuntu-latest"}
-          - PYTHON: { VERSION: "pp310-pypy310_pp73" }
-            MANYLINUX: { NAME: "manylinux2014_aarch64", CONTAINER: "cryptography-manylinux2014_aarch64", RUNNER: "ubuntu-24.04-arm" }
           - PYTHON: { VERSION: "pp311-pypy311_pp73" }
             MANYLINUX: { NAME: "manylinux2014_x86_64", CONTAINER: "cryptography-manylinux2014:x86_64", RUNNER: "ubuntu-latest"}
           - PYTHON: { VERSION: "pp311-pypy311_pp73" }
             MANYLINUX: { NAME: "manylinux2014_aarch64", CONTAINER: "cryptography-manylinux2014_aarch64", RUNNER: "ubuntu-24.04-arm" }
 
           # No PyPy on armv7l either
-          - PYTHON: { VERSION: "pp310-pypy310_pp73" }
-            MANYLINUX: { NAME: "manylinux_2_31_armv7l", CONTAINER: "cryptography-manylinux_2_31:armv7l", RUNNER: "ubuntu-24.04-arm" }
           - PYTHON: { VERSION: "pp311-pypy311_pp73" }
             MANYLINUX: { NAME: "manylinux_2_31_armv7l", CONTAINER: "cryptography-manylinux_2_31:armv7l", RUNNER: "ubuntu-24.04-arm" }
 
           # No PyPy on ppc64le
           - PYTHON: { VERSION: "pp311-pypy311_pp73" }
             MANYLINUX: { NAME: "manylinux_2_34_ppc64le", CONTAINER: "cryptography-manylinux_2_34:ppc64le", RUNNER: "ubuntu-24.04-ppc64le" }
-          - PYTHON: { VERSION: "pp310-pypy310_pp73" }
-            MANYLINUX: { NAME: "manylinux_2_28_ppc64le", CONTAINER: "cryptography-manylinux_2_28:ppc64le", RUNNER: "ubuntu-24.04-ppc64le" }
-          - PYTHON: { VERSION: "pp310-pypy310_pp73" }
-            MANYLINUX: { NAME: "manylinux_2_34_ppc64le", CONTAINER: "cryptography-manylinux_2_34:ppc64le", RUNNER: "ubuntu-24.04-ppc64le" }
           - PYTHON: { VERSION: "pp311-pypy311_pp73" }
             MANYLINUX: { NAME: "manylinux_2_28_ppc64le", CONTAINER: "cryptography-manylinux_2_28:ppc64le", RUNNER: "ubuntu-24.04-ppc64le" }
 
diff --git a/CHANGELOG.rst b/CHANGELOG.rst
index 97cd2e3d4013..db99eb9b8851 100644
--- a/CHANGELOG.rst
+++ b/CHANGELOG.rst
@@ -3,10 +3,8 @@ Changelog
 
 .. _v46-0-0:
 
-46.0.0 - `main`_
-~~~~~~~~~~~~~~~~
-
-.. note:: This version is not yet released and is under active development.
+46.0.0 - 2025-09-16
+~~~~~~~~~~~~~~~~~~~
 
 * **BACKWARDS INCOMPATIBLE:** Support for Python 3.7 has been removed.
 * Support for OpenSSL < 3.0 is deprecated and will be removed in the next
diff --git a/docs/installation.rst b/docs/installation.rst
index e15dd82727fe..edf526b9e6c9 100644
--- a/docs/installation.rst
+++ b/docs/installation.rst
@@ -21,7 +21,7 @@ single most common cause of installation problems.
 Supported platforms
 -------------------
 
-Currently we test ``cryptography`` on Python 3.8+ and PyPy3 7.3.11+ on these
+Currently we test ``cryptography`` on Python 3.8+ and PyPy3.11 on these
 operating systems.
 
 * x86-64 RHEL 8.x
diff --git a/pyproject.toml b/pyproject.toml
index 5c4a6117082a..531956cec174 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -16,7 +16,7 @@ build-backend = "maturin"
 
 [project]
 name = "cryptography"
-version = "46.0.0.dev1"
+version = "46.0.0"
 authors = [
     { name = "The Python Cryptographic Authority and individual contributors", email = "cryptography-dev@python.org" },
 ]
@@ -70,7 +70,7 @@ ssh = ["bcrypt >=3.1.5"]
 # All the following are used for our own testing.
 nox = ["nox[uv] >=2024.04.15"]
 test = [
-    "cryptography_vectors",
+    "cryptography_vectors==46.0.0",
     "pytest >=7.4.0",
     "pytest-benchmark >=4.0",
     "pytest-cov >=2.10.1",
diff --git a/src/cryptography/__about__.py b/src/cryptography/__about__.py
index 3f2801afaee5..8315b8f5990b 100644
--- a/src/cryptography/__about__.py
+++ b/src/cryptography/__about__.py
@@ -10,7 +10,7 @@
     "__version__",
 ]
 
-__version__ = "46.0.0.dev1"
+__version__ = "46.0.0"
 
 
 __author__ = "The Python Cryptographic Authority and individual contributors"
diff --git a/vectors/cryptography_vectors/__about__.py b/vectors/cryptography_vectors/__about__.py
index 335089253b72..146618d3db77 100644
--- a/vectors/cryptography_vectors/__about__.py
+++ b/vectors/cryptography_vectors/__about__.py
@@ -6,4 +6,4 @@
     "__version__",
 ]
 
-__version__ = "46.0.0.dev1"
+__version__ = "46.0.0"
diff --git a/vectors/pyproject.toml b/vectors/pyproject.toml
index 59aeb2dba59d..5b4a4e7108fd 100644
--- a/vectors/pyproject.toml
+++ b/vectors/pyproject.toml
@@ -4,7 +4,7 @@ build-backend = "uv_build"
 
 [project]
 name = "cryptography_vectors"
-version = "46.0.0.dev1"
+version = "46.0.0"
 authors = [
     {name = "The Python Cryptographic Authority and individual contributors", email = "cryptography-dev@python.org"}
 ]