diff --git a/rsconnect/main.py b/rsconnect/main.py
index 357d2b9a..02ff5384 100644
--- a/rsconnect/main.py
+++ b/rsconnect/main.py
@@ -1741,6 +1741,7 @@ def deploy_app(
 generate_deploy_python(app_mode=AppModes.BOKEH_APP, alias="bokeh", min_version="1.8.4")
 generate_deploy_python(app_mode=AppModes.PYTHON_SHINY, alias="shiny", min_version="2022.07.0")
 generate_deploy_python(app_mode=AppModes.PYTHON_GRADIO, alias="gradio", min_version="2024.12.0")
+generate_deploy_python(app_mode=AppModes.PYTHON_PANEL, alias="panel", min_version="2025.10.0")
 
 
 @deploy.command(
@@ -2278,6 +2279,7 @@ def manifest_writer(
 generate_write_manifest_python(AppModes.PYTHON_SHINY, alias="shiny")
 generate_write_manifest_python(AppModes.STREAMLIT_APP, alias="streamlit")
 generate_write_manifest_python(AppModes.PYTHON_GRADIO, alias="gradio")
+generate_write_manifest_python(AppModes.PYTHON_PANEL, alias="panel")
 
 
 # noinspection SpellCheckingInspection
diff --git a/rsconnect/models.py b/rsconnect/models.py
index bfaf5a2e..c6fd5c07 100644
--- a/rsconnect/models.py
+++ b/rsconnect/models.py
@@ -98,6 +98,7 @@ class AppModes:
     PYTHON_SHINY = AppMode(15, "python-shiny", "Python Shiny Application")
     JUPYTER_VOILA = AppMode(16, "jupyter-voila", "Jupyter Voila Application")
     PYTHON_GRADIO = AppMode(17, "python-gradio", "Gradio Application")
+    PYTHON_PANEL = AppMode(18, "python-panel", "HoloViz Panel Application")
 
     _modes = [
         UNKNOWN,
@@ -118,6 +119,7 @@ class AppModes:
         PYTHON_SHINY,
         JUPYTER_VOILA,
         PYTHON_GRADIO,
+        PYTHON_PANEL,
     ]
 
     Modes = Literal[
@@ -139,6 +141,7 @@ class AppModes:
         "python-shiny",
         "jupyter-voila",
         "python-gradio",
+        "python-panel",
     ]
 
     _cloud_to_connect_modes = {
diff --git a/tests/test_bundle.py b/tests/test_bundle.py
index e300954e..7cab72ed 100644
--- a/tests/test_bundle.py
+++ b/tests/test_bundle.py
@@ -2868,6 +2868,76 @@ def test_make_api_bundle_gradio():
         assert gradio_dir_ans["files"].keys() == bundle_json["files"].keys()
 
 
+panel_dir = os.path.join(cur_dir, "./testdata/panel")
+panel_file = os.path.join(cur_dir, "./testdata/panel/app.py")
+
+
+def test_make_api_manifest_panel():
+    panel_dir_ans = {
+        "version": 1,
+        "locale": "en_US.UTF-8",
+        "metadata": {"appmode": "python-panel"},
+        "python": {
+            "version": "3.8.12",
+            "package_manager": {"name": "pip", "version": "23.0.1", "package_file": "requirements.txt"},
+        },
+        "files": {
+            "requirements.txt": {"checksum": "f90113cfbf5f67bfa6c5c6a5a8bc7eaa"},
+            "app.py": {"checksum": "e3b0c44298fc1c149afbf4c8996fb924"},
+        },
+    }
+    environment = Environment.create_python_environment(
+        panel_dir,
+    )
+    manifest, _ = make_api_manifest(
+        panel_dir,
+        None,
+        AppModes.PYTHON_PANEL,
+        environment,
+        None,
+        None,
+    )
+
+    assert panel_dir_ans["metadata"] == manifest["metadata"]
+    assert panel_dir_ans["files"].keys() == manifest["files"].keys()
+
+
+def test_make_api_bundle_panel():
+    panel_dir_ans = {
+        "version": 1,
+        "locale": "en_US.UTF-8",
+        "metadata": {"appmode": "python-panel"},
+        "python": {
+            "version": "3.8.12",
+            "package_manager": {"name": "pip", "version": "23.0.1", "package_file": "requirements.txt"},
+        },
+        "files": {
+            "requirements.txt": {"checksum": "f90113cfbf5f67bfa6c5c6a5a8bc7eaa"},
+            "app.py": {"checksum": "e3b0c44298fc1c149afbf4c8996fb924"},
+        },
+    }
+    environment = Environment.create_python_environment(
+        panel_dir,
+    )
+    with make_api_bundle(
+        panel_dir,
+        None,
+        AppModes.PYTHON_PANEL,
+        environment,
+        None,
+        None,
+    ) as bundle, tarfile.open(mode="r:gz", fileobj=bundle) as tar:
+        names = sorted(tar.getnames())
+        assert names == [
+            "app.py",
+            "manifest.json",
+            "requirements.txt",
+        ]
+        bundle_json = json.loads(tar.extractfile("manifest.json").read().decode("utf-8"))
+        assert panel_dir_ans["metadata"] == bundle_json["metadata"]
+        assert panel_dir_ans["files"].keys() == bundle_json["files"].keys()
+
+
 empty_manifest_file = os.path.join(cur_dir, "./testdata/Manifest_data/empty_manifest.json")
 missing_file_manifest = os.path.join(cur_dir, "./testdata/Manifest_data/missing_file_manifest.json")
 
diff --git a/tests/testdata/panel/app.py b/tests/testdata/panel/app.py
new file mode 100644
index 00000000..09c384a5
--- /dev/null
+++ b/tests/testdata/panel/app.py
@@ -0,0 +1,24 @@
+import panel as pn
+
+pn.extension()
+
+
+def greet(name):
+    return f"Hello, {name}!"
+
+
+text_input = pn.widgets.TextInput(name="Enter your name", placeholder="Type here...")
+button = pn.widgets.Button(name="Greet", button_type="primary")
+
+output = pn.pane.Markdown("Click the button to see a greeting!")
+
+
+def update_output(event):
+    output.object = greet(text_input.value)
+
+
+button.on_click(update_output)
+
+app = pn.Column("# Panel Greeting App", text_input, button, output)
+
+app.servable()
diff --git a/tests/testdata/panel/requirements.txt b/tests/testdata/panel/requirements.txt
new file mode 100644
index 00000000..f9ec12dd
--- /dev/null
+++ b/tests/testdata/panel/requirements.txt
@@ -0,0 +1 @@
+panel