diff --git a/plugins/node/opentelemetry-instrumentation-mongodb/.tav.yml b/plugins/node/opentelemetry-instrumentation-mongodb/.tav.yml
index 86a2bf927d..518c012a77 100644
--- a/plugins/node/opentelemetry-instrumentation-mongodb/.tav.yml
+++ b/plugins/node/opentelemetry-instrumentation-mongodb/.tav.yml
@@ -5,7 +5,10 @@ mongodb:
     - versions: ">=4 <5"
       commands: npm run test-v4
     - versions: ">=5 <6"
-      commands: npm run test-v5
+      commands: npm run test-v5-v6
+    - versions: ">=6 <7"
+      node: '>=15.0.0'
+      commands: npm run test-v5-v6
 
   # Fix missing `contrib-test-utils` package
-  pretest: npm run --prefix ../../../ lerna:link
+  pretest: npm run --prefix ../../../ lerna:link
\ No newline at end of file
diff --git a/plugins/node/opentelemetry-instrumentation-mongodb/README.md b/plugins/node/opentelemetry-instrumentation-mongodb/README.md
index 3ace4bd595..b6c7c16192 100644
--- a/plugins/node/opentelemetry-instrumentation-mongodb/README.md
+++ b/plugins/node/opentelemetry-instrumentation-mongodb/README.md
@@ -17,7 +17,7 @@ npm install --save @opentelemetry/instrumentation-mongodb
 
 ### Supported Versions
 
-- `>=3.3 <5`
+- `>=3.3 <7`
 
 ## Usage
 
diff --git a/plugins/node/opentelemetry-instrumentation-mongodb/package.json b/plugins/node/opentelemetry-instrumentation-mongodb/package.json
index f5e50569f0..64a3d848d4 100644
--- a/plugins/node/opentelemetry-instrumentation-mongodb/package.json
+++ b/plugins/node/opentelemetry-instrumentation-mongodb/package.json
@@ -9,8 +9,8 @@
     "docker:start": "docker run -e MONGODB_DB=opentelemetry-tests -e MONGODB_PORT=27017 -e MONGODB_HOST=127.0.0.1 -p 27017:27017 --rm mongo",
     "test": "npm run test-v3",
     "test-v3": "nyc ts-mocha -p tsconfig.json --require '@opentelemetry/contrib-test-utils' 'test/**/mongodb-v3.test.ts'",
-    "test-v4": "nyc ts-mocha -p tsconfig.json --require '@opentelemetry/contrib-test-utils' 'test/mongodb-v4-v5.metrics.test.ts' 'test/**/mongodb-v4.test.ts'",
-    "test-v5": "nyc ts-mocha -p tsconfig.json --require '@opentelemetry/contrib-test-utils' 'test/mongodb-v4-v5.metrics.test.ts' 'test/**/mongodb-v5.test.ts'",
+    "test-v4": "nyc ts-mocha -p tsconfig.json --require '@opentelemetry/contrib-test-utils' 'test/mongodb-v4-v5-v6.metrics.test.ts' 'test/**/mongodb-v4.test.ts'",
+    "test-v5-v6": "nyc ts-mocha -p tsconfig.json --require '@opentelemetry/contrib-test-utils' 'test/mongodb-v4-v5-v6.metrics.test.ts' 'test/**/mongodb-v5-v6.test.ts'",
     "test-all-versions": "tav",
     "tdd": "npm run test -- --watch-extensions ts --watch",
     "clean": "rimraf build/*",
diff --git a/plugins/node/opentelemetry-instrumentation-mongodb/src/instrumentation.ts b/plugins/node/opentelemetry-instrumentation-mongodb/src/instrumentation.ts
index f44e0df2b2..3be3019848 100644
--- a/plugins/node/opentelemetry-instrumentation-mongodb/src/instrumentation.ts
+++ b/plugins/node/opentelemetry-instrumentation-mongodb/src/instrumentation.ts
@@ -97,31 +97,31 @@ export class MongoDBInstrumentation extends InstrumentationBase {
       ),
       new InstrumentationNodeModuleDefinition<any>(
         'mongodb',
-        ['4.*', '5.*'],
+        ['4.*', '5.*', '6.*'],
         undefined,
         undefined,
         [
           new InstrumentationNodeModuleFile<V4Connection>(
             'mongodb/lib/cmap/connection.js',
-            ['4.*', '5.*'],
+            ['4.*', '5.*', '6.*'],
             v4PatchConnection,
             v4UnpatchConnection
           ),
           new InstrumentationNodeModuleFile<V4ConnectionPool>(
             'mongodb/lib/cmap/connection_pool.js',
-            ['4.*', '5.*'],
+            ['4.*', '5.*', '6.*'],
             v4PatchConnectionPool,
             v4UnpatchConnectionPool
           ),
           new InstrumentationNodeModuleFile<V4Connect>(
             'mongodb/lib/cmap/connect.js',
-            ['4.*', '5.*'],
+            ['4.*', '5.*', '6.*'],
             v4PatchConnect,
             v4UnpatchConnect
           ),
           new InstrumentationNodeModuleFile<V4Session>(
             'mongodb/lib/sessions.js',
-            ['4.*', '5.*'],
+            ['4.*', '5.*', '6.*'],
             v4PatchSessions,
             v4UnpatchSessions
           ),
diff --git a/plugins/node/opentelemetry-instrumentation-mongodb/test/mongodb-v4-v5.metrics.test.ts b/plugins/node/opentelemetry-instrumentation-mongodb/test/mongodb-v4-v5-v6.metrics.test.ts
similarity index 100%
rename from plugins/node/opentelemetry-instrumentation-mongodb/test/mongodb-v4-v5.metrics.test.ts
rename to plugins/node/opentelemetry-instrumentation-mongodb/test/mongodb-v4-v5-v6.metrics.test.ts
diff --git a/plugins/node/opentelemetry-instrumentation-mongodb/test/mongodb-v5.test.ts b/plugins/node/opentelemetry-instrumentation-mongodb/test/mongodb-v5-v6.test.ts
similarity index 100%
rename from plugins/node/opentelemetry-instrumentation-mongodb/test/mongodb-v5.test.ts
rename to plugins/node/opentelemetry-instrumentation-mongodb/test/mongodb-v5-v6.test.ts