diff --git a/Cargo.lock b/Cargo.lock
index 437a2d67..72caf850 100644
--- a/Cargo.lock
+++ b/Cargo.lock
@@ -160,6 +160,12 @@ dependencies = [
  "num",
 ]
 
+[[package]]
+name = "ascii"
+version = "1.1.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "d92bec98840b8f03a5ff5413de5293bfcd8bf96467cf5452609f939ec6f5de16"
+
 [[package]]
 name = "assert-json-diff"
 version = "1.1.0"
@@ -585,9 +591,9 @@ checksum = "9e1b586273c5702936fe7b7d6896644d8be71e6314cfe09d3167c95f712589e8"
 
 [[package]]
 name = "base64"
-version = "0.21.0"
+version = "0.21.5"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "a4a4ddaa51a5bc52a6948f74c06d20aaaddb71924eab79b8c97a8c556e942d6a"
+checksum = "35636a1494ede3b646cc98f74f8e62c773a38a659ebc777a2cf26b9b74171df9"
 
 [[package]]
 name = "base64-simd"
@@ -620,6 +626,15 @@ dependencies = [
  "generic-array",
 ]
 
+[[package]]
+name = "blosc-src"
+version = "0.1.1"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "3c3372aaf42f24a767cfe596161cbfac42c60bd9e034e50d4f63cfebe13f68f4"
+dependencies = [
+ "cmake",
+]
+
 [[package]]
 name = "brotli"
 version = "3.4.0"
@@ -739,6 +754,15 @@ dependencies = [
  "os_str_bytes",
 ]
 
+[[package]]
+name = "cmake"
+version = "0.1.50"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "a31c789563b815f77f4250caee12365734369f942439b7defd71e18a48197130"
+dependencies = [
+ "cc",
+]
+
 [[package]]
 name = "const-random"
 version = "0.1.15"
@@ -804,16 +828,6 @@ dependencies = [
  "cfg-if",
 ]
 
-[[package]]
-name = "crossbeam-channel"
-version = "0.5.6"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "c2dd04ddaf88237dc3b8d8f9a3c1004b506b54b3313403944054d23c0870c521"
-dependencies = [
- "cfg-if",
- "crossbeam-utils",
-]
-
 [[package]]
 name = "crossbeam-deque"
 version = "0.8.2"
@@ -892,7 +906,7 @@ source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "6d2301688392eb071b0bf1a37be05c469d3cc4dbbd95df672fe28ab021e6a096"
 dependencies = [
  "quote",
- "syn",
+ "syn 1.0.109",
 ]
 
 [[package]]
@@ -905,7 +919,7 @@ dependencies = [
  "hashbrown 0.12.3",
  "lock_api",
  "once_cell",
- "parking_lot_core",
+ "parking_lot_core 0.9.7",
  "rayon",
 ]
 
@@ -934,7 +948,7 @@ checksum = "adc2ab4d5a16117f9029e9a6b5e4e79f4c67f6519bc134210d4d4a04ba31f41b"
 dependencies = [
  "proc-macro2",
  "quote",
- "syn",
+ "syn 1.0.109",
 ]
 
 [[package]]
@@ -965,6 +979,33 @@ dependencies = [
  "termcolor",
 ]
 
+[[package]]
+name = "equivalent"
+version = "1.0.1"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "5443807d6dff69373d433ab9ef5378ad8df50ca6298caf15de6e52e24aaf54d5"
+
+[[package]]
+name = "errno"
+version = "0.2.8"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "f639046355ee4f37944e44f60642c6f3a7efa3cf6b78c78a0d989a8ce6c396a1"
+dependencies = [
+ "errno-dragonfly",
+ "libc",
+ "winapi",
+]
+
+[[package]]
+name = "errno-dragonfly"
+version = "0.1.2"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "aa68f1b12764fab894d2755d2518754e71b4fd80ecfb822714a1206c2aab39bf"
+dependencies = [
+ "cc",
+ "libc",
+]
+
 [[package]]
 name = "extend"
 version = "0.1.2"
@@ -974,7 +1015,7 @@ dependencies = [
  "proc-macro-error",
  "proc-macro2",
  "quote",
- "syn",
+ "syn 1.0.109",
 ]
 
 [[package]]
@@ -1015,6 +1056,7 @@ source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "f82b0f4c27ad9f8bfd1f3208d882da2b09c301bc1c828fd3a00d0216d2fbbff6"
 dependencies = [
  "crc32fast",
+ "libz-sys",
  "miniz_oxide",
 ]
 
@@ -1089,7 +1131,7 @@ checksum = "bdfb8ce053d86b91919aad980c220b1fb8401a9394410e1c289ed7e66b61835d"
 dependencies = [
  "proc-macro2",
  "quote",
- "syn",
+ "syn 1.0.109",
 ]
 
 [[package]]
@@ -1155,7 +1197,7 @@ dependencies = [
  "futures-sink",
  "futures-util",
  "http",
- "indexmap",
+ "indexmap 1.9.1",
  "slab",
  "tokio",
  "tokio-util",
@@ -1198,6 +1240,77 @@ dependencies = [
  "hashbrown 0.14.0",
 ]
 
+[[package]]
+name = "hdf5"
+version = "0.8.1"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "bdcd9b131fd67bb827b386d0dc63d3e74196a14616ef800acf87ca5fef741a10"
+dependencies = [
+ "bitflags 1.3.2",
+ "blosc-src",
+ "cfg-if",
+ "errno",
+ "hdf5-derive",
+ "hdf5-sys",
+ "hdf5-types",
+ "lazy_static",
+ "libc",
+ "lzf-sys",
+ "ndarray",
+ "parking_lot",
+ "paste",
+]
+
+[[package]]
+name = "hdf5-derive"
+version = "0.8.1"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "a5a77ac6a41e6880594d506118c0b8bc665ec959fe4636e0c84809756d224820"
+dependencies = [
+ "proc-macro2",
+ "quote",
+ "syn 1.0.109",
+]
+
+[[package]]
+name = "hdf5-src"
+version = "0.8.1"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "e01493db39ddc0519cf2a83d620d2c037fee60f4fed724cb72dc23763f1727a8"
+dependencies = [
+ "cmake",
+ "libz-sys",
+]
+
+[[package]]
+name = "hdf5-sys"
+version = "0.8.1"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "4842d5980dc311a7c8933c7b45534fdae84df5ae7939a0ae8e449a56d4beb3d2"
+dependencies = [
+ "hdf5-src",
+ "libc",
+ "libloading",
+ "libz-sys",
+ "pkg-config",
+ "regex",
+ "serde",
+ "serde_derive",
+ "winreg",
+]
+
+[[package]]
+name = "hdf5-types"
+version = "0.8.1"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "b47268c0dfb499b1ffe5638b6e7694e7a87fe49fb92eca998a4346e5483e428f"
+dependencies = [
+ "ascii",
+ "cfg-if",
+ "hdf5-sys",
+ "libc",
+]
+
 [[package]]
 name = "hermit-abi"
 version = "0.1.19"
@@ -1358,6 +1471,17 @@ dependencies = [
  "hashbrown 0.12.3",
 ]
 
+[[package]]
+name = "indexmap"
+version = "2.0.1"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "ad227c3af19d4914570ad36d30409928b75967c298feb9ea1969db3a610bb14e"
+dependencies = [
+ "equivalent",
+ "hashbrown 0.14.0",
+ "serde",
+]
+
 [[package]]
 name = "instant"
 version = "0.1.12"
@@ -1494,6 +1618,16 @@ version = "0.2.147"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "b4668fb0ea861c1df094127ac5f1da3409a82116a4ba74fca2e58ef927159bb3"
 
+[[package]]
+name = "libloading"
+version = "0.7.4"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "b67380fd3b2fbe7527a606e18729d21c6f3951633d0500574c4dc22d2d638b9f"
+dependencies = [
+ "cfg-if",
+ "winapi",
+]
+
 [[package]]
 name = "libm"
 version = "0.2.8"
@@ -1511,6 +1645,17 @@ dependencies = [
  "vcpkg",
 ]
 
+[[package]]
+name = "libz-sys"
+version = "1.1.12"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "d97137b25e321a73eef1418d1d5d2eda4d77e12813f8e6dead84bc52c5870a7b"
+dependencies = [
+ "cc",
+ "pkg-config",
+ "vcpkg",
+]
+
 [[package]]
 name = "linreg"
 version = "0.2.0"
@@ -1533,12 +1678,9 @@ dependencies = [
 
 [[package]]
 name = "log"
-version = "0.4.17"
+version = "0.4.20"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "abb12e687cfb44aa40f41fc3978ef76448f9b6038cad6aef4259d3c095a2382e"
-dependencies = [
- "cfg-if",
-]
+checksum = "b5e6163cb8c49088c2c36f57875e58ccd8c87c7427f7fbd50ea6710b2f3f2e8f"
 
 [[package]]
 name = "lz4"
@@ -1560,6 +1702,25 @@ dependencies = [
  "libc",
 ]
 
+[[package]]
+name = "lzf-sys"
+version = "0.1.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "0798d023ce0905e2c77ed96de92aab929ff9db2036cbef4edfee0daf33582aec"
+dependencies = [
+ "cc",
+]
+
+[[package]]
+name = "matrixmultiply"
+version = "0.3.8"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "7574c1cf36da4798ab73da5b215bbf444f50718207754cb522201d78d1cd0ff2"
+dependencies = [
+ "autocfg",
+ "rawpointer",
+]
+
 [[package]]
 name = "md-5"
 version = "0.10.5"
@@ -1569,6 +1730,12 @@ dependencies = [
  "digest",
 ]
 
+[[package]]
+name = "md5"
+version = "0.7.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "490cc448043f947bae3cbee9c203358d62dbee0db12107a74be5c30ccfd09771"
+
 [[package]]
 name = "memchr"
 version = "2.5.0"
@@ -1611,6 +1778,51 @@ dependencies = [
  "windows-sys 0.42.0",
 ]
 
+[[package]]
+name = "mzdata"
+version = "0.11.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "9cf6f27be7fb811470287cb72fcad6fd3c1212eb33918798bfccc2ab25f988f6"
+dependencies = [
+ "base64-simd",
+ "bytemuck",
+ "flate2",
+ "hdf5",
+ "hdf5-sys",
+ "indexmap 2.0.1",
+ "lazy_static",
+ "libz-sys",
+ "log",
+ "md5",
+ "mzpeaks",
+ "ndarray",
+ "num-traits",
+ "quick-xml",
+ "regex",
+ "serde",
+ "serde_json",
+ "thiserror",
+]
+
+[[package]]
+name = "mzpeaks"
+version = "0.9.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "d519a4d34d369ad9869553909c659de71e682119d58f00861d11be2978a25e67"
+
+[[package]]
+name = "ndarray"
+version = "0.15.6"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "adb12d4e967ec485a5f71c6311fe28158e9d6f4bc4a447b474184d0f91a8fa32"
+dependencies = [
+ "matrixmultiply",
+ "num-complex",
+ "num-integer",
+ "num-traits",
+ "rawpointer",
+]
+
 [[package]]
 name = "ntapi"
 version = "0.4.1"
@@ -1758,6 +1970,31 @@ version = "0.5.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "4030760ffd992bef45b0ae3f10ce1aba99e33464c90d14dd7c039884963ddc7a"
 
+[[package]]
+name = "parking_lot"
+version = "0.11.2"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "7d17b78036a60663b797adeaee46f5c9dfebb86948d1255007a1d6be0271ff99"
+dependencies = [
+ "instant",
+ "lock_api",
+ "parking_lot_core 0.8.6",
+]
+
+[[package]]
+name = "parking_lot_core"
+version = "0.8.6"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "60a2cfe6f0ad2bfc16aefa463b497d5c7a5ecd44a23efa72aa342d90177356dc"
+dependencies = [
+ "cfg-if",
+ "instant",
+ "libc",
+ "redox_syscall",
+ "smallvec",
+ "winapi",
+]
+
 [[package]]
 name = "parking_lot_core"
 version = "0.9.7"
@@ -1785,7 +2022,7 @@ dependencies = [
  "arrow-ipc",
  "arrow-schema",
  "arrow-select",
- "base64 0.21.0",
+ "base64 0.21.5",
  "brotli",
  "bytes",
  "chrono",
@@ -1850,7 +2087,7 @@ checksum = "069bdb1e05adc7a8990dce9cc75370895fbe4e3d58b9b73bf1aee56359344a55"
 dependencies = [
  "proc-macro2",
  "quote",
- "syn",
+ "syn 1.0.109",
 ]
 
 [[package]]
@@ -1892,7 +2129,7 @@ dependencies = [
  "proc-macro-error-attr",
  "proc-macro2",
  "quote",
- "syn",
+ "syn 1.0.109",
  "version_check",
 ]
 
@@ -1915,9 +2152,9 @@ checksum = "dc375e1527247fe1a97d8b7156678dfe7c1af2fc075c9a4db3690ecd2a148068"
 
 [[package]]
 name = "proc-macro2"
-version = "1.0.47"
+version = "1.0.69"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "5ea3d908b0e36316caf9e9e2c4625cdde190a7e6f440d794667ed17a1855e725"
+checksum = "134c189feb4956b20f6f547d2cf727d4c0fe06722b20a0eec87ed445a97f92da"
 dependencies = [
  "unicode-ident",
 ]
@@ -1929,6 +2166,7 @@ source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "eff6510e86862b57b210fd8cbe8ed3f0d7d600b9c2863cd4549a2e033c66e956"
 dependencies = [
  "memchr",
+ "serde",
  "tokio",
 ]
 
@@ -1951,14 +2189,14 @@ checksum = "b22a693222d716a9587786f37ac3f6b4faedb5b80c23914e7303ff5a1d8016e9"
 dependencies = [
  "proc-macro2",
  "quote",
- "syn",
+ "syn 1.0.109",
 ]
 
 [[package]]
 name = "quote"
-version = "1.0.21"
+version = "1.0.33"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "bbe448f377a7d6961e30f5955f9b8d106c3f5e449d493ee1b125c1d43c2b5179"
+checksum = "5267fca4496028628a95160fc423a33e8b2e6af8a5302579e322e4b520293cae"
 dependencies = [
  "proc-macro2",
 ]
@@ -1981,28 +2219,30 @@ dependencies = [
  "getrandom",
 ]
 
+[[package]]
+name = "rawpointer"
+version = "0.2.1"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "60a357793950651c4ed0f3f52338f53b2f809f32d83a07f72909fa13e4c6c1e3"
+
 [[package]]
 name = "rayon"
-version = "1.5.3"
+version = "1.8.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "bd99e5772ead8baa5215278c9b15bf92087709e9c1b2d1f97cdb5a183c933a7d"
+checksum = "9c27db03db7734835b3f53954b534c91069375ce6ccaa2e065441e07d9b6cdb1"
 dependencies = [
- "autocfg",
- "crossbeam-deque",
  "either",
  "rayon-core",
 ]
 
 [[package]]
 name = "rayon-core"
-version = "1.9.3"
+version = "1.12.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "258bcdb5ac6dad48491bb2992db6b7cf74878b0384908af124823d118c99683f"
+checksum = "5ce3fb6ad83f861aac485e76e1985cd109d9a3713802152be56c3b1f0e0658ed"
 dependencies = [
- "crossbeam-channel",
  "crossbeam-deque",
  "crossbeam-utils",
- "num_cpus",
 ]
 
 [[package]]
@@ -2043,7 +2283,7 @@ version = "0.11.18"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "cde824a14b7c14f85caff81225f411faacc04a2013f41670f41443742b1c1c55"
 dependencies = [
- "base64 0.21.0",
+ "base64 0.21.5",
  "bytes",
  "encoding_rs",
  "futures-core",
@@ -2179,7 +2419,7 @@ version = "1.0.2"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "d194b56d58803a43635bdc398cd17e383d6f71f9182b9a192c127ca42494a59b"
 dependencies = [
- "base64 0.21.0",
+ "base64 0.21.5",
 ]
 
 [[package]]
@@ -2232,6 +2472,7 @@ dependencies = [
  "futures",
  "http",
  "log",
+ "mzdata",
  "once_cell",
  "parquet 44.0.0",
  "quick-xml",
@@ -2324,29 +2565,29 @@ checksum = "a3f0bf26fd526d2a95683cd0f87bf103b8539e2ca1ef48ce002d67aad59aa0b4"
 
 [[package]]
 name = "serde"
-version = "1.0.147"
+version = "1.0.193"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "d193d69bae983fc11a79df82342761dfbf28a99fc8d203dca4c3c1b590948965"
+checksum = "25dd9975e68d0cb5aa1120c288333fc98731bd1dd12f561e468ea4728c042b89"
 dependencies = [
  "serde_derive",
 ]
 
 [[package]]
 name = "serde_derive"
-version = "1.0.147"
+version = "1.0.193"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "4f1d362ca8fc9c3e3a7484440752472d68a6caa98f1ab81d99b5dfe517cec852"
+checksum = "43576ca501357b9b071ac53cdc7da8ef0cbd9493d8df094cd821777ea6e894d3"
 dependencies = [
  "proc-macro2",
  "quote",
- "syn",
+ "syn 2.0.39",
 ]
 
 [[package]]
 name = "serde_json"
-version = "1.0.87"
+version = "1.0.108"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "6ce777b7b150d76b9cf60d28b55f5847135a003f7d7350c6be7a773508ce7d45"
+checksum = "3d1c7e3eac408d115102c4c24ad393e0821bb3a5df4d506a80f85f7a742a526b"
 dependencies = [
  "itoa 1.0.4",
  "ryu",
@@ -2450,9 +2691,20 @@ checksum = "6bdef32e8150c2a081110b42772ffe7d7c9032b606bc226c8260fd97e0976601"
 
 [[package]]
 name = "syn"
-version = "1.0.103"
+version = "1.0.109"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "72b64191b275b66ffe2469e8af2c1cfe3bafa67b529ead792a6d0160888b4237"
+dependencies = [
+ "proc-macro2",
+ "quote",
+ "unicode-ident",
+]
+
+[[package]]
+name = "syn"
+version = "2.0.39"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "a864042229133ada95abf3b54fdc62ef5ccabe9515b64717bcb9a1919e59445d"
+checksum = "23e78b90f2fcf45d3e842032ce32e3f2d1545ba6636271dcbf24fa306d87be7a"
 dependencies = [
  "proc-macro2",
  "quote",
@@ -2485,22 +2737,22 @@ dependencies = [
 
 [[package]]
 name = "thiserror"
-version = "1.0.39"
+version = "1.0.50"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "a5ab016db510546d856297882807df8da66a16fb8c4101cb8b30054b0d5b2d9c"
+checksum = "f9a7210f5c9a7156bb50aa36aed4c95afb51df0df00713949448cf9e97d382d2"
 dependencies = [
  "thiserror-impl",
 ]
 
 [[package]]
 name = "thiserror-impl"
-version = "1.0.39"
+version = "1.0.50"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "5420d42e90af0c38c3290abcca25b9b3bdf379fc9f55c528f53a269d9c9a267e"
+checksum = "266b2e40bc00e5a6c09c3584011e08b06f123c00362c92b975ba9843aaaa14b8"
 dependencies = [
  "proc-macro2",
  "quote",
- "syn",
+ "syn 2.0.39",
 ]
 
 [[package]]
@@ -2607,7 +2859,7 @@ checksum = "d266c00fde287f55d3f1c3e96c500c362a2b8c695076ec180f27918820bc6df8"
 dependencies = [
  "proc-macro2",
  "quote",
- "syn",
+ "syn 1.0.109",
 ]
 
 [[package]]
@@ -2705,7 +2957,7 @@ checksum = "4017f8f45139870ca7e672686113917c71c7a6e02d4924eda67186083c03081a"
 dependencies = [
  "proc-macro2",
  "quote",
- "syn",
+ "syn 1.0.109",
 ]
 
 [[package]]
@@ -2859,7 +3111,7 @@ dependencies = [
  "once_cell",
  "proc-macro2",
  "quote",
- "syn",
+ "syn 1.0.109",
  "wasm-bindgen-shared",
 ]
 
@@ -2893,7 +3145,7 @@ checksum = "07bc0c051dc5f23e307b13285f9d75df86bfdf816c5721e573dec1f9b8aa193c"
 dependencies = [
  "proc-macro2",
  "quote",
- "syn",
+ "syn 1.0.109",
  "wasm-bindgen-backend",
  "wasm-bindgen-shared",
 ]
@@ -3169,6 +3421,7 @@ version = "0.10.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "80d0f4e272c85def139476380b12f9ac60926689dd2e01d4923222f40580869d"
 dependencies = [
+ "serde",
  "winapi",
 ]
 
diff --git a/crates/sage-cli/Cargo.toml b/crates/sage-cli/Cargo.toml
index 842a7d1e..da5b71d8 100644
--- a/crates/sage-cli/Cargo.toml
+++ b/crates/sage-cli/Cargo.toml
@@ -14,6 +14,14 @@ license = "MIT"
 name = "sage"
 path = "src/main.rs"
 
+
+[features]
+
+default = []
+
+mzmlb = ["sage-cloudpath/mzdata"]
+
+
 [dependencies]
 sage-core = { path = "../sage" }
 sage-cloudpath = { path = "../sage-cloudpath", features = ["parquet"] }
diff --git a/crates/sage-cli/src/main.rs b/crates/sage-cli/src/main.rs
index 16d414c8..87b9fd23 100644
--- a/crates/sage-cli/src/main.rs
+++ b/crates/sage-cli/src/main.rs
@@ -200,12 +200,22 @@ impl Runner {
 
                 let path_lower = path.to_lowercase();
                 let res = if path_lower.ends_with(".mgf.gz") || path_lower.ends_with(".mgf") {
-                    sage_cloudpath::util::read_mgf(path_lower, file_id)
+                    sage_cloudpath::util::read_mgf(path, file_id)
                 } else if bruker_extensions
                     .iter()
                     .any(|ext| path_lower.ends_with(ext))
                 {
                     sage_cloudpath::util::read_tdf(path, file_id)
+                } else if path_lower.ends_with(".mzmlb") {
+                    #[cfg(feature = "mzmlb")]
+                    {
+                        sage_cloudpath::util::read_mzmlb(path, file_id, sn)
+                    }
+                    #[cfg(not(feature = "mzmlb"))]
+                    {
+                        // Fall back to prior behavior
+                        sage_cloudpath::util::read_mzml(path, file_id, sn)
+                    }
                 } else {
                     sage_cloudpath::util::read_mzml(path, file_id, sn)
                 };
diff --git a/crates/sage-cloudpath/Cargo.toml b/crates/sage-cloudpath/Cargo.toml
index 70c53c1c..e0461a7f 100644
--- a/crates/sage-cloudpath/Cargo.toml
+++ b/crates/sage-cloudpath/Cargo.toml
@@ -10,6 +10,9 @@ license = "MIT"
 
 # See more keys and their definitions at https://doc.rust-lang.org/cargo/reference/manifest.html
 
+[features]
+default = []
+
 [dependencies]
 thiserror = "1.0"
 async-compression = { version = "0.3", features = ["tokio", "gzip", "zlib"] }
@@ -33,3 +36,5 @@ serde_json = "1.0"
 
 sage-core = { path = "../sage" }
 parquet = { version = "44.0.0", optional = true, default-features = false, features = ["zstd"] }
+
+mzdata = {version = "0.11.0", default-features = false, features = ["mzmlb", "hdf5_static", "zlib"], optional = true}
diff --git a/crates/sage-cloudpath/src/lib.rs b/crates/sage-cloudpath/src/lib.rs
index 930be015..17c3bf05 100644
--- a/crates/sage-cloudpath/src/lib.rs
+++ b/crates/sage-cloudpath/src/lib.rs
@@ -8,6 +8,8 @@ use tokio::io::{AsyncBufRead, AsyncRead, AsyncWriteExt, BufReader};
 
 pub mod mgf;
 pub mod mzml;
+#[cfg(feature = "mzdata")]
+pub mod mzmlb;
 pub mod tdf;
 pub mod util;
 
diff --git a/crates/sage-cloudpath/src/mzmlb.rs b/crates/sage-cloudpath/src/mzmlb.rs
new file mode 100644
index 00000000..26f26e0e
--- /dev/null
+++ b/crates/sage-cloudpath/src/mzmlb.rs
@@ -0,0 +1,131 @@
+#![cfg(feature = "mzdata")]
+
+use std::io;
+use std::path::Path;
+
+use mzdata::io::MzMLbReader as MzMLbReaderImpl;
+use mzdata::prelude::*;
+use mzdata::RawSpectrum as RawSpectrumImpl;
+use sage_core::mass::Tolerance;
+use sage_core::spectrum::{Precursor, RawSpectrum};
+
+pub struct MzMLbReader {
+    ms_level: Option<u8>,
+    // If set to Some(level) and noise intensities are present in the MzML file,
+    // divide intensities at this MS-level by noise to calculate S/N
+    signal_to_noise: Option<u8>,
+
+    file_id: usize,
+}
+
+impl MzMLbReader {
+    /// Create a new [`MzMLbReader`] with a minimum MS level filter
+    ///
+    /// # Example
+    ///
+    /// A minimum level of 2 will not parse or return MS1 scans
+    pub fn with_file_id_and_level_filter(file_id: usize, ms_level: u8) -> Self {
+        Self {
+            ms_level: Some(ms_level),
+            file_id,
+            signal_to_noise: None,
+        }
+    }
+
+    pub fn with_file_id(file_id: usize) -> Self {
+        Self {
+            ms_level: None,
+            signal_to_noise: None,
+            file_id,
+        }
+    }
+
+    pub fn set_file_id(&mut self, file_id: usize) -> &mut Self {
+        self.file_id = file_id;
+        self
+    }
+
+    pub fn set_signal_to_noise(&mut self, sn: Option<u8>) -> &mut Self {
+        self.signal_to_noise = sn;
+        self
+    }
+
+    pub fn parse<B>(&self, b: B) -> Result<Vec<RawSpectrum>, io::Error>
+    where
+        B: AsRef<Path>,
+    {
+        let reader = MzMLbReaderImpl::new(&b)?;
+
+        let spectra = reader
+            .into_iter()
+            .filter(|scan| {
+                if let Some(ms_level) = self.ms_level {
+                    return scan.ms_level() == ms_level;
+                } else {
+                    return true;
+                }
+            })
+            .map(|scan| {
+                let scan: RawSpectrumImpl = scan.into();
+                let mut precusors = Vec::new();
+                match scan.precursor() {
+                    Some(p) => {
+                        let p = Precursor {
+                            mz: p.mz() as f32,
+                            intensity: Some(p.ion.intensity),
+                            charge: p.ion.charge.and_then(|v| Some(v as u8)),
+                            spectrum_ref: p.precursor_id.clone(),
+                            isolation_window: Some(Tolerance::Da(
+                                p.isolation_window.lower_bound as f32,
+                                p.isolation_window.upper_bound as f32,
+                            )),
+                        };
+                        precusors.push(p)
+                    }
+                    None => {}
+                }
+                RawSpectrum {
+                    file_id: self.file_id,
+                    ms_level: scan.ms_level(),
+                    id: scan.description.id.clone(),
+                    precursors: precusors,
+                    ion_injection_time: scan.acquisition().first_scan().unwrap().injection_time,
+                    representation: match scan.description.signal_continuity {
+                        mzdata::spectrum::SignalContinuity::Unknown => {
+                            sage_core::spectrum::Representation::Profile
+                        }
+                        mzdata::spectrum::SignalContinuity::Centroid => {
+                            sage_core::spectrum::Representation::Centroid
+                        }
+                        mzdata::spectrum::SignalContinuity::Profile => {
+                            sage_core::spectrum::Representation::Profile
+                        }
+                    },
+                    scan_start_time: scan.start_time() as f32,
+                    total_ion_current: scan.peaks().tic(),
+                    mz: scan.mzs().iter().map(|mz| (*mz) as f32).collect(),
+                    intensity: scan.intensities().to_vec(),
+                }
+            })
+            .collect();
+        Ok(spectra)
+    }
+}
+
+
+#[cfg(test)]
+mod test {
+    use super::*;
+
+    #[test]
+    fn test_read_mzmlb() -> io::Result<()> {
+        let spectra = MzMLbReader::with_file_id(0).parse("../../tests/LQSRPAAPPAPGPGQLTLR.mzMLb")?;
+        assert_eq!(spectra.len(), 1);
+        let s = spectra.first().unwrap();
+        assert_eq!(s.id, "controllerType=0 controllerNumber=1 scan=30069");
+        assert_eq!(s.mz.len(), 299);
+        assert_eq!(s.intensity.len(), 299);
+        Ok(())
+    }
+
+}
\ No newline at end of file
diff --git a/crates/sage-cloudpath/src/util.rs b/crates/sage-cloudpath/src/util.rs
index badb95b6..e6770818 100644
--- a/crates/sage-cloudpath/src/util.rs
+++ b/crates/sage-cloudpath/src/util.rs
@@ -24,6 +24,21 @@ pub fn read_tdf<S: AsRef<str>>(s: S, file_id: usize) -> Result<Vec<RawSpectrum>,
     }
 }
 
+#[cfg(feature = "mzdata")]
+pub fn read_mzmlb<S: AsRef<str>>(
+    s: S,
+    file_id: usize,
+    signal_to_noise: Option<u8>,
+) -> Result<Vec<RawSpectrum>, Error> {
+    let res = crate::mzmlb::MzMLbReader::with_file_id(file_id)
+        .set_signal_to_noise(signal_to_noise)
+        .parse(s.as_ref());
+    match res {
+        Ok(spectra) => Ok(spectra),
+        Err(e) => Err(Error::IO(e)),
+    }
+}
+
 pub fn read_mgf<S: AsRef<str>>(path: S, file_id: usize) -> Result<Vec<RawSpectrum>, Error> {
     read_and_execute(path, |mut bf| async move {
         let mut contents = String::new();
diff --git a/tests/LQSRPAAPPAPGPGQLTLR.mzMLb b/tests/LQSRPAAPPAPGPGQLTLR.mzMLb
new file mode 100644
index 00000000..814f8402
Binary files /dev/null and b/tests/LQSRPAAPPAPGPGQLTLR.mzMLb differ