diff --git a/docker/docker-development.sh b/docker/docker-development.sh
index ec210f66..a35c84cf 100755
--- a/docker/docker-development.sh
+++ b/docker/docker-development.sh
@@ -89,7 +89,7 @@ else
         # Also explicitly copy the .env file
         cp ../src/.env ingest-ui/src
 
-        docker compose -f docker-compose.yml -f docker-compose.development.yml -p ingest-ui build
+        docker compose -f docker-compose.yml -f docker-compose.development.yml -p ingest-ui build --no-cache
     elif [ "$1" = "start" ]; then
         docker compose -f docker-compose.yml -f docker-compose.development.yml -p ingest-ui up -d
     elif [ "$1" = "stop" ]; then
@@ -97,4 +97,4 @@ else
     elif [ "$1" = "down" ]; then
         docker compose -f docker-compose.yml -f docker-compose.development.yml -p ingest-ui down
     fi
-fi
+fi
\ No newline at end of file
diff --git a/docker/ingest-ui/Dockerfile b/docker/ingest-ui/Dockerfile
index 72da03c3..1e9da01d 100644
--- a/docker/ingest-ui/Dockerfile
+++ b/docker/ingest-ui/Dockerfile
@@ -1,5 +1,5 @@
 # Parent image
-FROM hubmap/api-base-image:1.1.0
+FROM hubmap/api-base-image:1.2.0
 
 LABEL description="HuBMAP Ingest UI"
 
@@ -9,46 +9,54 @@ WORKDIR /usr/src/app
 # Copy from host to image
 COPY . .
 
-# http://nginx.org/en/linux_packages.html#RHEL-CentOS
-# Set up the yum repository to install the latest mainline version of Nginx
-RUN echo $'[nginx-mainline]\n\
-name=nginx mainline repo\n\
-baseurl=http://nginx.org/packages/mainline/centos/$releasever/$basearch/\n\
-gpgcheck=1\n\
-enabled=0\n\
-gpgkey=https://nginx.org/keys/nginx_signing.key\n\
-module_hotfixes=true\n'\
->> /etc/yum.repos.d/nginx.repo
+# Set up the repository file for the stable version of
+# nginx which dnf should use (in the legacy "yum" location.)
+RUN set -eux && \
+    cat <<'EOF' > /etc/yum.repos.d/nginx.repo
+[nginx-stable]
+name=nginx stable repo
+baseurl=http://nginx.org/packages/centos/$releasever/$basearch/
+gpgcheck=1
+enabled=1
+gpgkey=https://nginx.org/keys/nginx_signing.key
+module_hotfixes=true
+EOF
 
 # Reduce the number of layers in image by minimizing the number of separate RUN commands
-# 1 - Install the prerequisites
-# 2 - By default, the repository for stable nginx packages is used. We would like to use mainline nginx packages
-# 3 - Install nginx (using the custom yum repo specified earlier)
-# 4 - Remove the default nginx config file
-# 5 - Overwrite the nginx.conf with ours to run nginx as non-root
-# 6 - Use our nginx config file for ingest-ui
-# 7 - Install Node.js v20.x (includes npm)
-# 8 - Update npm to the latest version
-# 9 - Make the start.sh executable
-# 10 - Clean all yum cache
-RUN yum install -y yum-utils && \
-    yum-config-manager --enable nginx-mainline && \
-    yum install -y nginx && \
-    rm /etc/nginx/conf.d/default.conf && \
+# 1 - Install nginx (using the custom dnf/yum repo specified earlier)
+# 2 - Remove the default nginx config file
+# 3 - Overwrite the nginx.conf with ours to run nginx as non-root
+# 4 - Use our nginx config file for ingest-ui
+# 5 - Make the start.sh executable
+# 6 - Clean the dnf/yum cache and other locations to reduce Docker Image layer size
+RUN dnf install -y nginx && \
+    [ ! -f /etc/nginx/conf.d/default.conf ] || mv /etc/nginx/conf.d/default.conf /tmp/etc_nginx_conf.d_default.conf.ORIGINAL && \
+    [ ! -f /etc/nginx/nginx.conf ] || mv /etc/nginx/nginx.conf /tmp/etc_nginx_nginx.conf.ORIGINAL && \
     mv nginx.conf /etc/nginx/nginx.conf && \
     mv ingest-ui.conf /etc/nginx/conf.d && \
-    curl -fsSL https://rpm.nodesource.com/setup_20.x | bash - && \
-    yum install -y nodejs && \
-    npm install npm@latest -g && \
-    chmod +x start.sh && \
-    yum clean all
+    [ ! -d nginx ] || mv nginx /tmp/nginx_from_WORKDIR && \
+    chmod a+x start.sh && \
+    dnf clean all && \
+    rm -rf /var/cache/dnf \
+        /var/log/dnf \
+         /var/log/yum \
+         /root/.cache
     
 # Change to source code directory
 WORKDIR /usr/src/app/src
 
-# Install dependencies and generate static production bundle with our custom tags
-# Delete node_modules to reduce image size
-RUN npm install && \
+# Reduce the number of layers in image by minimizing the number of separate RUN commands
+# 1 - Download and install nvm:
+# 2 - In lieu of restarting the shell
+# 3 - Download and install Node.js v24
+# 4 - Update npm to the latest version
+# 5 - Install dependencies and generate static production bundle with our custom tags
+# 6 - Delete node_modules to reduce image size
+RUN curl -o- https://raw.githubusercontent.com/nvm-sh/nvm/v0.40.3/install.sh | bash && \
+    \. "$HOME/.nvm/nvm.sh" && \
+    nvm install 24 && \
+    npm install npm@latest -g && \
+    npm install && \
     npm run build:tags && \
     rm -rf node_modules
 
diff --git a/docker/ingest-ui/start.sh b/docker/ingest-ui/start.sh
index f6fe6c52..8393411f 100755
--- a/docker/ingest-ui/start.sh
+++ b/docker/ingest-ui/start.sh
@@ -1,7 +1,9 @@
 #!/bin/bash
 
 # Replace the custom tags with deployment specific .env
-python /usr/src/app/src/envs/env_tool.py /usr/src/app/src/.env /usr/src/app/src/build &
+# NOTE: Explicitly call the Python executable with its full path instead of just `python` or `python3.13`
+# This is due to the api-base-image v1.2.0 uses aliases
+/usr/local/bin/python3.13 /usr/src/app/src/envs/env_tool.py /usr/src/app/src/.env /usr/src/app/src/build &
 
 # Start nginx to serve the static build
 nginx -g 'daemon off;'
\ No newline at end of file