From e37135c0302c2018e17f00a5cfd92c1276578dca Mon Sep 17 00:00:00 2001 From: satvshr Date: Mon, 7 Jul 2025 13:21:32 +0530 Subject: [PATCH 001/145] Added the pseaac encoding algorithm --- AptaNet/pseaac.py | 593 ++++++++++++++++++++++++++++++++++++++++++++++ 1 file changed, 593 insertions(+) create mode 100644 AptaNet/pseaac.py diff --git a/AptaNet/pseaac.py b/AptaNet/pseaac.py new file mode 100644 index 00000000..9a109fba --- /dev/null +++ b/AptaNet/pseaac.py @@ -0,0 +1,593 @@ +def pseaac(self, protein_sequence): + # The hydrophobicity values are from JACS, 1962, 84: 4240-4246. (C. Tanford). + P1 = { + "A": 0.62, + "C": 0.29, + "D": -0.90, + "E": -0.74, + "F": 1.19, + "G": 0.48, + "H": -0.40, + "I": 1.38, + "K": -1.50, + "L": 1.06, + "M": 0.64, + "N": -0.78, + "P": 0.12, + "Q": -0.85, + "R": -2.53, + "S": -0.18, + "T": -0.05, + "V": 1.08, + "W": 0.81, + "Y": 0.26, + } + + # The hydrophilicity values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods). + P2 = { + "A": -0.5, + "C": -1.0, + "D": 3.0, + "E": 3.0, + "F": -2.5, + "G": 0.0, + "H": -0.5, + "I": -1.8, + "K": 3.0, + "L": -1.8, + "M": -1.3, + "N": 0.2, + "P": 0.0, + "Q": 0.2, + "R": 3.0, + "S": 0.3, + "T": -0.4, + "V": -1.5, + "W": -3.4, + "Y": -2.3, + } + + # The side-chain mass for each of the 20 amino acids. + P3 = { + "A": 15.0, + "C": 47.0, + "D": 59.0, + "E": 73.0, + "F": 91.0, + "G": 1.0, + "H": 82.0, + "I": 57.0, + "K": 73.0, + "L": 57.0, + "M": 75.0, + "N": 58.0, + "P": 42.0, + "Q": 72.0, + "R": 101.0, + "S": 31.0, + "T": 45.0, + "V": 43.0, + "W": 130.0, + "Y": 107.0, + } + + # The Polarity values are from JACS, 1962, 84: 4240-4246. (C. Tanford). + P4 = { + "A": 0.5, + "C": 2.5, + "D": -1, + "E": 2.5, + "F": -2.5, + "G": 0, + "H": -0.5, + "I": 1.8, + "K": 3, + "L": -1.8, + "M": -1.3, + "N": 0.2, + "P": -1.4, + "Q": 0.2, + "R": 3, + "S": 0.3, + "T": -0.4, + "V": -1.5, + "W": -3.4, + "Y": -2.3, + } + + # The Molecular weight values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods). + P5 = { + "A": 5.3, + "C": 3.6, + "D": 1.3, + "E": 3.3, + "F": 2.3, + "G": 4.8, + "H": 1.4, + "I": 3.1, + "K": 4.1, + "L": 4.7, + "M": 1.1, + "N": 3, + "P": 2.5, + "Q": 2.4, + "R": 2.6, + "S": 4.5, + "T": 3.7, + "V": 4.2, + "W": 0.8, + "Y": 2.3, + } + + # The Meling point for each of the 20 amino acids. + P6 = { + "A": 0.81, + "C": 0.71, + "D": 1.17, + "E": 0.53, + "F": 1.2, + "G": 0.88, + "H": 0.92, + "I": 1.48, + "K": 0.77, + "L": 1.24, + "M": 1.05, + "N": 0.62, + "P": 0.61, + "Q": 0.98, + "R": 0.85, + "S": 0.92, + "T": 1.18, + "V": 1.66, + "W": 1.18, + "Y": 1.23, + } + + # The Transfer_free_energy values are from JACS, 1962, 84: 4240-4246. (C. Tanford). + P7 = { + "A": 58, + "C": -97, + "D": 116, + "E": -131, + "F": 92, + "G": -11, + "H": -73, + "I": 107, + "K": -24, + "L": 95, + "M": 78, + "N": -93, + "P": -79, + "Q": -139, + "R": -184, + "S": -34, + "T": -7, + "V": 100, + "W": 59, + "Y": -11, + } + + # The Buriability values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods). + P8 = { + "A": 1.37, + "C": 8.93, + "D": -4.47, + "E": 4.04, + "F": -7.96, + "G": 3.39, + "H": -1.65, + "I": -7.92, + "K": 7.7, + "L": -8.68, + "M": -7.13, + "N": 6.29, + "P": 6.25, + "Q": 3.88, + "R": 1.33, + "S": 4.08, + "T": 4.02, + "V": -6.94, + "W": 0.79, + "Y": -4.73, + } + + # The Bulkiness for each of the 20 amino acids. + P9 = { + "A": 6.77, + "C": 8.57, + "D": 0.31, + "E": 12.93, + "F": 1.92, + "G": 7.95, + "H": 2.8, + "I": 2.72, + "K": 10.2, + "L": 4.43, + "M": 1.87, + "N": 5.5, + "P": 4.79, + "Q": 5.24, + "R": 6.87, + "S": 5.41, + "T": 5.36, + "V": 3.57, + "W": 0.54, + "Y": 2.26, + } + + # The Solvation_free_energy values are from JACS, 1962, 84: 4240-4246. (C. Tanford). + P10 = { + "A": 0.87, + "C": 0.66, + "D": 1.52, + "E": 0.67, + "F": 2.87, + "G": 0.1, + "H": 0.87, + "I": 3.15, + "K": 1.64, + "L": 2.17, + "M": 1.67, + "N": 0.09, + "P": 2.77, + "Q": 0, + "R": 0.85, + "S": 0.07, + "T": 0.07, + "V": 1.87, + "W": 3.77, + "Y": 2.67, + } + + # The Relative_mutability values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods). + P11 = { + "A": 1.09, + "C": 0.77, + "D": 0.5, + "E": 0.92, + "F": 0.5, + "G": 1.25, + "H": 0.67, + "I": 0.66, + "K": 1.25, + "L": 0.44, + "M": 0.45, + "N": 1.14, + "P": 2.96, + "Q": 0.83, + "R": 0.97, + "S": 1.21, + "T": 1.33, + "V": 0.56, + "W": 0.62, + "Y": 0.94, + } + + # The Residue_volume for each of the 20 amino acids. + P12 = { + "A": 0.91, + "C": 1.4, + "D": 0.93, + "E": 0.97, + "F": 0.72, + "G": 1.51, + "H": 0.9, + "I": 0.65, + "K": 0.82, + "L": 0.59, + "M": 0.58, + "N": 1.64, + "P": 1.66, + "Q": 0.94, + "R": 1, + "S": 1.23, + "T": 1.04, + "V": 0.6, + "W": 0.67, + "Y": 0.92, + } + + # The volume values are from JACS, 1962, 84: 4240-4246. (C. Tanford). + P13 = { + "A": 0.92, + "C": 0.48, + "D": 1.16, + "E": 0.61, + "F": 1.25, + "G": 0.61, + "H": 0.93, + "I": 1.81, + "K": 0.7, + "L": 1.3, + "M": 1.19, + "N": 0.6, + "P": 0.4, + "Q": 0.95, + "R": 0.93, + "S": 0.82, + "T": 1.12, + "V": 1.81, + "W": 1.54, + "Y": 1.53, + } + + # The Amino_acid_distribution values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods). + P14 = { + "A": 0.96, + "C": 0.9, + "D": 1.13, + "E": 0.33, + "F": 1.37, + "G": 0.9, + "H": 0.87, + "I": 1.54, + "K": 0.81, + "L": 1.26, + "M": 1.29, + "N": 0.72, + "P": 0.75, + "Q": 1.18, + "R": 0.67, + "S": 0.77, + "T": 1.23, + "V": 1.41, + "W": 1.13, + "Y": 1.07, + } + + # The Hydration_number for each of the 20 amino acids. + P15 = { + "A": 0.9, + "C": 0.47, + "D": 1.24, + "E": 0.62, + "F": 1.23, + "G": 0.56, + "H": 1.12, + "I": 1.54, + "K": 0.74, + "L": 1.26, + "M": 1.09, + "N": 0.62, + "P": 0.42, + "Q": 1.18, + "R": 1.02, + "S": 0.87, + "T": 1.3, + "V": 1.53, + "W": 1.75, + "Y": 1.68, + } + + # The Isoelectric_point values are from JACS, 1962, 84: 4240-4246. (C. Tanford). + P16 = { + "A": 6, + "C": 5.05, + "D": 2.77, + "E": 5.22, + "F": 5.48, + "G": 5.97, + "H": 7.59, + "I": 6.02, + "K": 9.74, + "L": 5.98, + "M": 5.74, + "N": 5.41, + "P": 6.3, + "Q": 5.65, + "R": 10.76, + "S": 5.68, + "T": 5.66, + "V": 5.96, + "W": 5.89, + "Y": 5.66, + } + + # The Compressibility values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods). + P17 = { + "A": -25.5, + "C": -32.82, + "D": -33.12, + "E": -36.17, + "F": -34.54, + "G": -27, + "H": -31.84, + "I": -31.78, + "K": -32.4, + "L": -31.78, + "M": -31.18, + "N": -30.9, + "P": -23.25, + "Q": -32.6, + "R": -26.62, + "S": -29.88, + "T": -31.23, + "V": -30.62, + "W": -30.24, + "Y": -35.01, + } + + # The Chromatographic_index for each of the 20 amino acids. + P18 = { + "A": 9.9, + "C": 2.8, + "D": 2.8, + "E": 3.2, + "F": 18.8, + "G": 5.6, + "H": 8.2, + "I": 17.1, + "K": 3.5, + "L": 17.6, + "M": 14.7, + "N": 5.4, + "P": 14.8, + "Q": 9, + "R": 4.6, + "S": 6.9, + "T": 9.5, + "V": 14.3, + "W": 17, + "Y": 15, + } + + # The Unfolding_entropy_change values are from JACS, 1962, 84: 4240-4246. (C. Tanford). + P19 = { + "A": 0.54, + "C": -4.14, + "D": -0.26, + "E": -0.19, + "F": -4.66, + "G": -0.31, + "H": -0.23, + "I": -0.27, + "K": 1.13, + "L": -0.24, + "M": -2.36, + "N": 1.74, + "P": -0.08, + "Q": 1.53, + "R": 3.69, + "S": -0.24, + "T": -0.28, + "V": -0.36, + "W": -2.69, + "Y": -2.82, + } + + # The Unfolding_entalpy_change values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods). + P20 = { + "A": 0.51, + "C": 5.21, + "D": 0.18, + "E": 0.05, + "F": 6.82, + "G": -0.23, + "H": 0.79, + "I": 0.19, + "K": -1.45, + "L": 0.17, + "M": 2.89, + "N": -2.03, + "P": 0.02, + "Q": -1.76, + "R": -4.4, + "S": -0.16, + "T": 0.04, + "V": 0.3, + "W": 4.47, + "Y": 3.73, + } + + # The Unfolding_Gibbs_free_energy_change for each of the 20 amino acids. + P21 = { + "A": -0.02, + "C": 1.08, + "D": -0.08, + "E": -0.13, + "F": 2.16, + "G": 0.09, + "H": 0.56, + "I": -0.08, + "K": -0.32, + "L": -0.08, + "M": 0.53, + "N": -0.3, + "P": -0.06, + "Q": -0.23, + "R": -0.71, + "S": -0.4, + "T": -0.24, + "V": -0.06, + "W": 1.78, + "Y": -0.91, + } + + # Define 7 selected groups of 3 properties each + prop_groups = [ + (P1, P2, P3), + (P4, P5, P6), + (P7, P8, P9), + (P10, P11, P12), + (P13, P14, P15), + (P16, P17, P18), + (P19, P20, P21), + ] + + def check_validity(self, seq): + for aa in seq: + if aa not in self.amino_acid: + raise ValueError( + f"Invalid amino acid '{aa}' found in protein_sequence. Only {self.amino_acid} are allowed." + ) + + # Function to normalize amino acid composition + def normalize_aa(self, seq): + count = {aa: 0 for aa in self.amino_acid} + for aa in seq: + if aa in count: + count[aa] += 1 + total = sum(count.values()) + return {aa: count[aa] / total if total > 0 else 0 for aa in count} + + # Normalize all physicochemical property dicts and store as a list + def normalize_properties(*property_dicts): + """ + Takes multiple amino acid property dictionaries and returns their normalized versions. + Normalization: (value - mean) / std deviation + Returns a list of normalized dictionaries in the same order. + """ + normalized = [] + for prop in property_dicts: + values = list(prop.values()) + mean_val = sum(values) / len(values) + std_val = (sum((v - mean_val) ** 2 for v in values) / len(values)) ** 0.5 + normalized.append( + {aa: (val - mean_val) / std_val for aa, val in prop.items()} + ) + return normalized + + def theta_RiRj(Ri, Rj, norm_props): + return sum((prop[Rj] - prop[Ri]) ** 2 for prop in norm_props) / len(norm_props) + + def sum_theta_val(seq, seq_len, LVal, n, norm_props): + return sum( + theta_RiRj(seq[i], seq[i + n], norm_props) for i in range(seq_len - LVal) + ) / (seq_len - n) + + check_validity(self, protein_sequence) + + lambda_val = 30 + weight = 0.15 + all_pseaac = [] + + if len(protein_sequence) <= lambda_val: + raise ValueError( + f"Sequence too short for Lambda={lambda_val}. Must be > {lambda_val}." + ) + + for group in prop_groups: + norm_props = normalize_properties(*group) + aa_freq = normalize_aa(self, protein_sequence) + sum_all_aa_freq = sum(aa_freq.values()) + + all_theta_val = [] + sum_all_theta_val = 0 + for n in range(1, lambda_val + 1): + theta_val = sum_theta_val( + protein_sequence, len(protein_sequence), lambda_val, n, norm_props + ) + all_theta_val.append(theta_val) + sum_all_theta_val += theta_val + + denominator_val = sum_all_aa_freq + (weight * sum_all_theta_val) + + # First 20 features: normalized amino acid composition + for aa in self.amino_acid: + all_pseaac.append(round((aa_freq[aa] / denominator_val), 3)) + + # Next 30 features: theta values + for theta_val in all_theta_val: + all_pseaac.append(round((weight * theta_val / denominator_val), 3)) + + return all_pseaac From 6ea5ff753125f6d832e62a623a7bc5d7a233d032 Mon Sep 17 00:00:00 2001 From: satvshr Date: Mon, 7 Jul 2025 13:23:00 +0530 Subject: [PATCH 002/145] Added Aptanet implementation --- AptaNet/aptanet.py | 48 +++++++++++++++++++++++ AptaNet/neural_net.py | 90 +++++++++++++++++++++++++++++++++++++++++++ 2 files changed, 138 insertions(+) create mode 100644 AptaNet/aptanet.py create mode 100644 AptaNet/neural_net.py diff --git a/AptaNet/aptanet.py b/AptaNet/aptanet.py new file mode 100644 index 00000000..ccf9fe68 --- /dev/null +++ b/AptaNet/aptanet.py @@ -0,0 +1,48 @@ +from AptaNet.pseaac import pseaac + +class AptaNet: + def __init__(self, aptamer_sequence, protein_sequence): + """ + Initialize the AptaNetInput class with an aptamer sequence and a protein sequence. + :param aptamer_sequence: The DNA sequence of the aptamer. + :param protein_sequence: The protein sequence to be analyzed. + """ + self.aptamer_sequence = aptamer_sequence + self.protein_sequence = protein_sequence + + # Define the 20 native amino acids according to the alphabetical order of their single-letter codes + self.amino_acid = list("ACDEFGHIKLMNPQRSTVWY") + + # Initialize the PseAAC object with the protein sequence + self.pseaac = pseaac(self, self.protein_sequence) + + # Do what repDNA is doing in the original code, i.e. generating all possible DNA pairs till k-mer length for the aptamer, and then normalizing the frequency to form a vector + def generate_kmer_vecs(self, aptamer_sequence, k=4): + from itertools import product + + bases = ["A", "C", "G", "T"] + + # Generate all possible k-mers from 1 to k + all_kmers = [] + for i in range(1, k + 1): + all_kmers.extend(["".join(p) for p in product(bases, repeat=i)]) + + # Count occurrences of each k-mer in the aptamer_sequence + kmer_counts = {kmer: 0 for kmer in all_kmers} + for i in range(len(aptamer_sequence)): + for j in range(1, k + 1): + if i + j <= len(aptamer_sequence): + kmer = aptamer_sequence[i:i + j] + if kmer in kmer_counts: + kmer_counts[kmer] += 1 + + # Normalize counts to frequencies (like normalize_aa) + total_kmers = sum(kmer_counts.values()) + kmer_freq = [kmer_counts[kmer] / total_kmers if total_kmers > 0 else 0 for kmer in all_kmers] + + return kmer_freq + + def generate_final_vector(self): + final_vector = self.generate_kmer_vecs(self.aptamer_sequence, k=4) + self.pseaac + + return final_vector \ No newline at end of file diff --git a/AptaNet/neural_net.py b/AptaNet/neural_net.py new file mode 100644 index 00000000..6c67bedc --- /dev/null +++ b/AptaNet/neural_net.py @@ -0,0 +1,90 @@ +import torch +import torch.nn as nn +import torch.optim as optim +import torch.nn.functional as F +from sklearn.ensemble import RandomForestClassifier +from sklearn.feature_selection import SelectFromModel + + +class MLP(nn.Module): + def __init__(self, input_dim=639): + super(MLP, self).__init__() + + self.input_dim = input_dim + + self.fc1 = nn.Linear(input_dim, 128) + self.dropout1 = nn.AlphaDropout(0.3) + self.fc2 = nn.Linear(128, 128) + self.dropout2 = nn.AlphaDropout(0.3) + self.fc3 = nn.Linear(128, 128) + self.dropout3 = nn.AlphaDropout(0.3) + self.fc4 = nn.Linear(128, 128) + self.dropout4 = nn.AlphaDropout(0.3) + self.fc5 = nn.Linear(128, 128) + self.dropout5 = nn.AlphaDropout(0.3) + self.fc6 = nn.Linear(128, 128) + self.dropout6 = nn.AlphaDropout(0.3) + self.fc7 = nn.Linear(128, 1) # Binary classification + + self.criterion = nn.BCELoss() + self.optimizer = None + + # Random forest feature selector + self.clf = RandomForestClassifier(n_estimators=300, max_depth=9, random_state=0) + self.clf_model = None + + def forward(self, x): + x = F.relu(self.fc1(x)) + x = self.dropout1(x) + x = F.relu(self.fc2(x)) + x = self.dropout2(x) + x = F.relu(self.fc3(x)) + x = self.dropout3(x) + x = F.relu(self.fc4(x)) + x = self.dropout4(x) + x = F.relu(self.fc5(x)) + x = self.dropout5(x) + x = F.relu(self.fc6(x)) + x = self.dropout6(x) + x = torch.sigmoid(self.fc7(x)) + return x + + def train_clf_model(self, X, y): + self.clf.fit(X, y) + self.clf_model = SelectFromModel(self.clf, prefit=True) + return self.clf_model + + def transform_X(self, X): + if self.clf_model is None: + raise ValueError("Classifier model has not been trained yet.") + return self.clf_model.transform(X) + + def fit_model(self, X, y, epochs=200, batch_size=310): + # Convert to PyTorch tensors + self.clf_model = self.train_clf_model(X, y) + X_transformed = self.transform_X(X) + X_tensor = torch.tensor(X_transformed, dtype=torch.float32) + y_tensor = torch.tensor(y, dtype=torch.float32).unsqueeze(1) + + self.optimizer = optim.RMSprop(self.parameters(), lr=0.00014, alpha=0.9, eps=1e-07) + + dataset = torch.utils.data.TensorDataset(X_tensor, y_tensor) + dataloader = torch.utils.data.DataLoader(dataset, batch_size=batch_size, shuffle=True) + + self.train() + for epoch in range(epochs): + for batch_x, batch_y in dataloader: + self.optimizer.zero_grad() + output = self.forward(batch_x) + loss = self.criterion(output, batch_y) + loss.backward() + self.optimizer.step() + + def predict(self, X): + self.eval() + X_transformed = self.transform_X(X) + X_tensor = torch.tensor(X_transformed, dtype=torch.float32) + with torch.no_grad(): + output = self.forward(X_tensor) + predictions = (output > 0.5).int().squeeze().numpy() + return predictions \ No newline at end of file From a5f01e030eb74b4566d27ea8aee3c1b0f4d5e77b Mon Sep 17 00:00:00 2001 From: satvshr Date: Mon, 7 Jul 2025 22:22:36 +0530 Subject: [PATCH 003/145] Made pseaac to a class and made the functions private, still working on tests and bug fixing --- AptaNet/pseaac.py | 1147 ++++++++++++++++++++-------------------- AptaNet/test_pseaac.py | 416 +++++++++++++++ 2 files changed, 995 insertions(+), 568 deletions(-) create mode 100644 AptaNet/test_pseaac.py diff --git a/AptaNet/pseaac.py b/AptaNet/pseaac.py index 9a109fba..c0d0b16a 100644 --- a/AptaNet/pseaac.py +++ b/AptaNet/pseaac.py @@ -1,520 +1,547 @@ -def pseaac(self, protein_sequence): - # The hydrophobicity values are from JACS, 1962, 84: 4240-4246. (C. Tanford). - P1 = { - "A": 0.62, - "C": 0.29, - "D": -0.90, - "E": -0.74, - "F": 1.19, - "G": 0.48, - "H": -0.40, - "I": 1.38, - "K": -1.50, - "L": 1.06, - "M": 0.64, - "N": -0.78, - "P": 0.12, - "Q": -0.85, - "R": -2.53, - "S": -0.18, - "T": -0.05, - "V": 1.08, - "W": 0.81, - "Y": 0.26, - } - - # The hydrophilicity values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods). - P2 = { - "A": -0.5, - "C": -1.0, - "D": 3.0, - "E": 3.0, - "F": -2.5, - "G": 0.0, - "H": -0.5, - "I": -1.8, - "K": 3.0, - "L": -1.8, - "M": -1.3, - "N": 0.2, - "P": 0.0, - "Q": 0.2, - "R": 3.0, - "S": 0.3, - "T": -0.4, - "V": -1.5, - "W": -3.4, - "Y": -2.3, - } - - # The side-chain mass for each of the 20 amino acids. - P3 = { - "A": 15.0, - "C": 47.0, - "D": 59.0, - "E": 73.0, - "F": 91.0, - "G": 1.0, - "H": 82.0, - "I": 57.0, - "K": 73.0, - "L": 57.0, - "M": 75.0, - "N": 58.0, - "P": 42.0, - "Q": 72.0, - "R": 101.0, - "S": 31.0, - "T": 45.0, - "V": 43.0, - "W": 130.0, - "Y": 107.0, - } - - # The Polarity values are from JACS, 1962, 84: 4240-4246. (C. Tanford). - P4 = { - "A": 0.5, - "C": 2.5, - "D": -1, - "E": 2.5, - "F": -2.5, - "G": 0, - "H": -0.5, - "I": 1.8, - "K": 3, - "L": -1.8, - "M": -1.3, - "N": 0.2, - "P": -1.4, - "Q": 0.2, - "R": 3, - "S": 0.3, - "T": -0.4, - "V": -1.5, - "W": -3.4, - "Y": -2.3, - } - - # The Molecular weight values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods). - P5 = { - "A": 5.3, - "C": 3.6, - "D": 1.3, - "E": 3.3, - "F": 2.3, - "G": 4.8, - "H": 1.4, - "I": 3.1, - "K": 4.1, - "L": 4.7, - "M": 1.1, - "N": 3, - "P": 2.5, - "Q": 2.4, - "R": 2.6, - "S": 4.5, - "T": 3.7, - "V": 4.2, - "W": 0.8, - "Y": 2.3, - } - - # The Meling point for each of the 20 amino acids. - P6 = { - "A": 0.81, - "C": 0.71, - "D": 1.17, - "E": 0.53, - "F": 1.2, - "G": 0.88, - "H": 0.92, - "I": 1.48, - "K": 0.77, - "L": 1.24, - "M": 1.05, - "N": 0.62, - "P": 0.61, - "Q": 0.98, - "R": 0.85, - "S": 0.92, - "T": 1.18, - "V": 1.66, - "W": 1.18, - "Y": 1.23, - } - - # The Transfer_free_energy values are from JACS, 1962, 84: 4240-4246. (C. Tanford). - P7 = { - "A": 58, - "C": -97, - "D": 116, - "E": -131, - "F": 92, - "G": -11, - "H": -73, - "I": 107, - "K": -24, - "L": 95, - "M": 78, - "N": -93, - "P": -79, - "Q": -139, - "R": -184, - "S": -34, - "T": -7, - "V": 100, - "W": 59, - "Y": -11, - } - - # The Buriability values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods). - P8 = { - "A": 1.37, - "C": 8.93, - "D": -4.47, - "E": 4.04, - "F": -7.96, - "G": 3.39, - "H": -1.65, - "I": -7.92, - "K": 7.7, - "L": -8.68, - "M": -7.13, - "N": 6.29, - "P": 6.25, - "Q": 3.88, - "R": 1.33, - "S": 4.08, - "T": 4.02, - "V": -6.94, - "W": 0.79, - "Y": -4.73, - } - - # The Bulkiness for each of the 20 amino acids. - P9 = { - "A": 6.77, - "C": 8.57, - "D": 0.31, - "E": 12.93, - "F": 1.92, - "G": 7.95, - "H": 2.8, - "I": 2.72, - "K": 10.2, - "L": 4.43, - "M": 1.87, - "N": 5.5, - "P": 4.79, - "Q": 5.24, - "R": 6.87, - "S": 5.41, - "T": 5.36, - "V": 3.57, - "W": 0.54, - "Y": 2.26, - } - - # The Solvation_free_energy values are from JACS, 1962, 84: 4240-4246. (C. Tanford). - P10 = { - "A": 0.87, - "C": 0.66, - "D": 1.52, - "E": 0.67, - "F": 2.87, - "G": 0.1, - "H": 0.87, - "I": 3.15, - "K": 1.64, - "L": 2.17, - "M": 1.67, - "N": 0.09, - "P": 2.77, - "Q": 0, - "R": 0.85, - "S": 0.07, - "T": 0.07, - "V": 1.87, - "W": 3.77, - "Y": 2.67, - } - - # The Relative_mutability values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods). - P11 = { - "A": 1.09, - "C": 0.77, - "D": 0.5, - "E": 0.92, - "F": 0.5, - "G": 1.25, - "H": 0.67, - "I": 0.66, - "K": 1.25, - "L": 0.44, - "M": 0.45, - "N": 1.14, - "P": 2.96, - "Q": 0.83, - "R": 0.97, - "S": 1.21, - "T": 1.33, - "V": 0.56, - "W": 0.62, - "Y": 0.94, - } - - # The Residue_volume for each of the 20 amino acids. - P12 = { - "A": 0.91, - "C": 1.4, - "D": 0.93, - "E": 0.97, - "F": 0.72, - "G": 1.51, - "H": 0.9, - "I": 0.65, - "K": 0.82, - "L": 0.59, - "M": 0.58, - "N": 1.64, - "P": 1.66, - "Q": 0.94, - "R": 1, - "S": 1.23, - "T": 1.04, - "V": 0.6, - "W": 0.67, - "Y": 0.92, - } - - # The volume values are from JACS, 1962, 84: 4240-4246. (C. Tanford). - P13 = { - "A": 0.92, - "C": 0.48, - "D": 1.16, - "E": 0.61, - "F": 1.25, - "G": 0.61, - "H": 0.93, - "I": 1.81, - "K": 0.7, - "L": 1.3, - "M": 1.19, - "N": 0.6, - "P": 0.4, - "Q": 0.95, - "R": 0.93, - "S": 0.82, - "T": 1.12, - "V": 1.81, - "W": 1.54, - "Y": 1.53, - } - - # The Amino_acid_distribution values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods). - P14 = { - "A": 0.96, - "C": 0.9, - "D": 1.13, - "E": 0.33, - "F": 1.37, - "G": 0.9, - "H": 0.87, - "I": 1.54, - "K": 0.81, - "L": 1.26, - "M": 1.29, - "N": 0.72, - "P": 0.75, - "Q": 1.18, - "R": 0.67, - "S": 0.77, - "T": 1.23, - "V": 1.41, - "W": 1.13, - "Y": 1.07, - } - - # The Hydration_number for each of the 20 amino acids. - P15 = { - "A": 0.9, - "C": 0.47, - "D": 1.24, - "E": 0.62, - "F": 1.23, - "G": 0.56, - "H": 1.12, - "I": 1.54, - "K": 0.74, - "L": 1.26, - "M": 1.09, - "N": 0.62, - "P": 0.42, - "Q": 1.18, - "R": 1.02, - "S": 0.87, - "T": 1.3, - "V": 1.53, - "W": 1.75, - "Y": 1.68, - } - - # The Isoelectric_point values are from JACS, 1962, 84: 4240-4246. (C. Tanford). - P16 = { - "A": 6, - "C": 5.05, - "D": 2.77, - "E": 5.22, - "F": 5.48, - "G": 5.97, - "H": 7.59, - "I": 6.02, - "K": 9.74, - "L": 5.98, - "M": 5.74, - "N": 5.41, - "P": 6.3, - "Q": 5.65, - "R": 10.76, - "S": 5.68, - "T": 5.66, - "V": 5.96, - "W": 5.89, - "Y": 5.66, - } - - # The Compressibility values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods). - P17 = { - "A": -25.5, - "C": -32.82, - "D": -33.12, - "E": -36.17, - "F": -34.54, - "G": -27, - "H": -31.84, - "I": -31.78, - "K": -32.4, - "L": -31.78, - "M": -31.18, - "N": -30.9, - "P": -23.25, - "Q": -32.6, - "R": -26.62, - "S": -29.88, - "T": -31.23, - "V": -30.62, - "W": -30.24, - "Y": -35.01, - } - - # The Chromatographic_index for each of the 20 amino acids. - P18 = { - "A": 9.9, - "C": 2.8, - "D": 2.8, - "E": 3.2, - "F": 18.8, - "G": 5.6, - "H": 8.2, - "I": 17.1, - "K": 3.5, - "L": 17.6, - "M": 14.7, - "N": 5.4, - "P": 14.8, - "Q": 9, - "R": 4.6, - "S": 6.9, - "T": 9.5, - "V": 14.3, - "W": 17, - "Y": 15, - } - - # The Unfolding_entropy_change values are from JACS, 1962, 84: 4240-4246. (C. Tanford). - P19 = { - "A": 0.54, - "C": -4.14, - "D": -0.26, - "E": -0.19, - "F": -4.66, - "G": -0.31, - "H": -0.23, - "I": -0.27, - "K": 1.13, - "L": -0.24, - "M": -2.36, - "N": 1.74, - "P": -0.08, - "Q": 1.53, - "R": 3.69, - "S": -0.24, - "T": -0.28, - "V": -0.36, - "W": -2.69, - "Y": -2.82, - } - - # The Unfolding_entalpy_change values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods). - P20 = { - "A": 0.51, - "C": 5.21, - "D": 0.18, - "E": 0.05, - "F": 6.82, - "G": -0.23, - "H": 0.79, - "I": 0.19, - "K": -1.45, - "L": 0.17, - "M": 2.89, - "N": -2.03, - "P": 0.02, - "Q": -1.76, - "R": -4.4, - "S": -0.16, - "T": 0.04, - "V": 0.3, - "W": 4.47, - "Y": 3.73, - } - - # The Unfolding_Gibbs_free_energy_change for each of the 20 amino acids. - P21 = { - "A": -0.02, - "C": 1.08, - "D": -0.08, - "E": -0.13, - "F": 2.16, - "G": 0.09, - "H": 0.56, - "I": -0.08, - "K": -0.32, - "L": -0.08, - "M": 0.53, - "N": -0.3, - "P": -0.06, - "Q": -0.23, - "R": -0.71, - "S": -0.4, - "T": -0.24, - "V": -0.06, - "W": 1.78, - "Y": -0.91, - } - - # Define 7 selected groups of 3 properties each - prop_groups = [ - (P1, P2, P3), - (P4, P5, P6), - (P7, P8, P9), - (P10, P11, P12), - (P13, P14, P15), - (P16, P17, P18), - (P19, P20, P21), - ] - - def check_validity(self, seq): +class PSeAAC: + def __init__(self, protein_sequence): + self.protein_sequence = protein_sequence + self.amino_acid = list("ACDEFGHIKLMNPQRSTVWY") + + # The hydrophobicity values are from JACS, 1962, 84: 4240-4246. (C. Tanford). + self.P1 = { + "A": 0.62, + "C": 0.29, + "D": -0.90, + "E": -0.74, + "F": 1.19, + "G": 0.48, + "H": -0.40, + "I": 1.38, + "K": -1.50, + "L": 1.06, + "M": 0.64, + "N": -0.78, + "P": 0.12, + "Q": -0.85, + "R": -2.53, + "S": -0.18, + "T": -0.05, + "V": 1.08, + "W": 0.81, + "Y": 0.26, + } + + # The hydrophilicity values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods). + self.P2 = { + "A": -0.5, + "C": -1.0, + "D": 3.0, + "E": 3.0, + "F": -2.5, + "G": 0.0, + "H": -0.5, + "I": -1.8, + "K": 3.0, + "L": -1.8, + "M": -1.3, + "N": 0.2, + "P": 0.0, + "Q": 0.2, + "R": 3.0, + "S": 0.3, + "T": -0.4, + "V": -1.5, + "W": -3.4, + "Y": -2.3, + } + + # The side-chain mass for each of the 20 amino acids. + self.P3 = { + "A": 15.0, + "C": 47.0, + "D": 59.0, + "E": 73.0, + "F": 91.0, + "G": 1.0, + "H": 82.0, + "I": 57.0, + "K": 73.0, + "L": 57.0, + "M": 75.0, + "N": 58.0, + "P": 42.0, + "Q": 72.0, + "R": 101.0, + "S": 31.0, + "T": 45.0, + "V": 43.0, + "W": 130.0, + "Y": 107.0, + } + + # The Polarity values are from JACS, 1962, 84: 4240-4246. (C. Tanford). + self.P4 = { + "A": 0.5, + "C": 2.5, + "D": -1, + "E": 2.5, + "F": -2.5, + "G": 0, + "H": -0.5, + "I": 1.8, + "K": 3, + "L": -1.8, + "M": -1.3, + "N": 0.2, + "P": -1.4, + "Q": 0.2, + "R": 3, + "S": 0.3, + "T": -0.4, + "V": -1.5, + "W": -3.4, + "Y": -2.3, + } + + # The Molecular weight values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods). + self.P5 = { + "A": 5.3, + "C": 3.6, + "D": 1.3, + "E": 3.3, + "F": 2.3, + "G": 4.8, + "H": 1.4, + "I": 3.1, + "K": 4.1, + "L": 4.7, + "M": 1.1, + "N": 3, + "P": 2.5, + "Q": 2.4, + "R": 2.6, + "S": 4.5, + "T": 3.7, + "V": 4.2, + "W": 0.8, + "Y": 2.3, + } + + # The Meling point for each of the 20 amino acids. + self.P6 = { + "A": 0.81, + "C": 0.71, + "D": 1.17, + "E": 0.53, + "F": 1.2, + "G": 0.88, + "H": 0.92, + "I": 1.48, + "K": 0.77, + "L": 1.24, + "M": 1.05, + "N": 0.62, + "P": 0.61, + "Q": 0.98, + "R": 0.85, + "S": 0.92, + "T": 1.18, + "V": 1.66, + "W": 1.18, + "Y": 1.23, + } + + # The Transfer_free_energy values are from JACS, 1962, 84: 4240-4246. (C. Tanford). + self.P7 = { + "A": 58, + "C": -97, + "D": 116, + "E": -131, + "F": 92, + "G": -11, + "H": -73, + "I": 107, + "K": -24, + "L": 95, + "M": 78, + "N": -93, + "P": -79, + "Q": -139, + "R": -184, + "S": -34, + "T": -7, + "V": 100, + "W": 59, + "Y": -11, + } + + # The Buriability values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods). + self.P8 = { + "A": 1.37, + "C": 8.93, + "D": -4.47, + "E": 4.04, + "F": -7.96, + "G": 3.39, + "H": -1.65, + "I": -7.92, + "K": 7.7, + "L": -8.68, + "M": -7.13, + "N": 6.29, + "P": 6.25, + "Q": 3.88, + "R": 1.33, + "S": 4.08, + "T": 4.02, + "V": -6.94, + "W": 0.79, + "Y": -4.73, + } + + # The Bulkiness for each of the 20 amino acids. + self.P9 = { + "A": 6.77, + "C": 8.57, + "D": 0.31, + "E": 12.93, + "F": 1.92, + "G": 7.95, + "H": 2.8, + "I": 2.72, + "K": 10.2, + "L": 4.43, + "M": 1.87, + "N": 5.5, + "P": 4.79, + "Q": 5.24, + "R": 6.87, + "S": 5.41, + "T": 5.36, + "V": 3.57, + "W": 0.54, + "Y": 2.26, + } + + # The Solvation_free_energy values are from JACS, 1962, 84: 4240-4246. (C. Tanford). + self.P10 = { + "A": 0.87, + "C": 0.66, + "D": 1.52, + "E": 0.67, + "F": 2.87, + "G": 0.1, + "H": 0.87, + "I": 3.15, + "K": 1.64, + "L": 2.17, + "M": 1.67, + "N": 0.09, + "P": 2.77, + "Q": 0, + "R": 0.85, + "S": 0.07, + "T": 0.07, + "V": 1.87, + "W": 3.77, + "Y": 2.67, + } + + # The Relative_mutability values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods). + self.P11 = { + "A": 1.09, + "C": 0.77, + "D": 0.5, + "E": 0.92, + "F": 0.5, + "G": 1.25, + "H": 0.67, + "I": 0.66, + "K": 1.25, + "L": 0.44, + "M": 0.45, + "N": 1.14, + "P": 2.96, + "Q": 0.83, + "R": 0.97, + "S": 1.21, + "T": 1.33, + "V": 0.56, + "W": 0.62, + "Y": 0.94, + } + + # The Residue_volume for each of the 20 amino acids. + self.P12 = { + "A": 0.91, + "C": 1.4, + "D": 0.93, + "E": 0.97, + "F": 0.72, + "G": 1.51, + "H": 0.9, + "I": 0.65, + "K": 0.82, + "L": 0.59, + "M": 0.58, + "N": 1.64, + "P": 1.66, + "Q": 0.94, + "R": 1, + "S": 1.23, + "T": 1.04, + "V": 0.6, + "W": 0.67, + "Y": 0.92, + } + + # The volume values are from JACS, 1962, 84: 4240-4246. (C. Tanford). + self.P13 = { + "A": 0.92, + "C": 0.48, + "D": 1.16, + "E": 0.61, + "F": 1.25, + "G": 0.61, + "H": 0.93, + "I": 1.81, + "K": 0.7, + "L": 1.3, + "M": 1.19, + "N": 0.6, + "P": 0.4, + "Q": 0.95, + "R": 0.93, + "S": 0.82, + "T": 1.12, + "V": 1.81, + "W": 1.54, + "Y": 1.53, + } + + # The Amino_acid_distribution values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods). + self.P14 = { + "A": 0.96, + "C": 0.9, + "D": 1.13, + "E": 0.33, + "F": 1.37, + "G": 0.9, + "H": 0.87, + "I": 1.54, + "K": 0.81, + "L": 1.26, + "M": 1.29, + "N": 0.72, + "P": 0.75, + "Q": 1.18, + "R": 0.67, + "S": 0.77, + "T": 1.23, + "V": 1.41, + "W": 1.13, + "Y": 1.07, + } + + # The Hydration_number for each of the 20 amino acids. + self.P15 = { + "A": 0.9, + "C": 0.47, + "D": 1.24, + "E": 0.62, + "F": 1.23, + "G": 0.56, + "H": 1.12, + "I": 1.54, + "K": 0.74, + "L": 1.26, + "M": 1.09, + "N": 0.62, + "P": 0.42, + "Q": 1.18, + "R": 1.02, + "S": 0.87, + "T": 1.3, + "V": 1.53, + "W": 1.75, + "Y": 1.68, + } + + # The Isoelectric_point values are from JACS, 1962, 84: 4240-4246. (C. Tanford). + self.P16 = { + "A": 6, + "C": 5.05, + "D": 2.77, + "E": 5.22, + "F": 5.48, + "G": 5.97, + "H": 7.59, + "I": 6.02, + "K": 9.74, + "L": 5.98, + "M": 5.74, + "N": 5.41, + "P": 6.3, + "Q": 5.65, + "R": 10.76, + "S": 5.68, + "T": 5.66, + "V": 5.96, + "W": 5.89, + "Y": 5.66, + } + + # The Compressibility values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods). + self.P17 = { + "A": -25.5, + "C": -32.82, + "D": -33.12, + "E": -36.17, + "F": -34.54, + "G": -27, + "H": -31.84, + "I": -31.78, + "K": -32.4, + "L": -31.78, + "M": -31.18, + "N": -30.9, + "P": -23.25, + "Q": -32.6, + "R": -26.62, + "S": -29.88, + "T": -31.23, + "V": -30.62, + "W": -30.24, + "Y": -35.01, + } + + # The Chromatographic_index for each of the 20 amino acids. + self.P18 = { + "A": 9.9, + "C": 2.8, + "D": 2.8, + "E": 3.2, + "F": 18.8, + "G": 5.6, + "H": 8.2, + "I": 17.1, + "K": 3.5, + "L": 17.6, + "M": 14.7, + "N": 5.4, + "P": 14.8, + "Q": 9, + "R": 4.6, + "S": 6.9, + "T": 9.5, + "V": 14.3, + "W": 17, + "Y": 15, + } + + # The Unfolding_entropy_change values are from JACS, 1962, 84: 4240-4246. (C. Tanford). + self.P19 = { + "A": 0.54, + "C": -4.14, + "D": -0.26, + "E": -0.19, + "F": -4.66, + "G": -0.31, + "H": -0.23, + "I": -0.27, + "K": 1.13, + "L": -0.24, + "M": -2.36, + "N": 1.74, + "P": -0.08, + "Q": 1.53, + "R": 3.69, + "S": -0.24, + "T": -0.28, + "V": -0.36, + "W": -2.69, + "Y": -2.82, + } + + # The Unfolding_entalpy_change values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods). + self.P20 = { + "A": 0.51, + "C": 5.21, + "D": 0.18, + "E": 0.05, + "F": 6.82, + "G": -0.23, + "H": 0.79, + "I": 0.19, + "K": -1.45, + "L": 0.17, + "M": 2.89, + "N": -2.03, + "P": 0.02, + "Q": -1.76, + "R": -4.4, + "S": -0.16, + "T": 0.04, + "V": 0.3, + "W": 4.47, + "Y": 3.73, + } + + # The Unfolding_Gibbs_free_energy_change for each of the 20 amino acids. + self.P21 = { + "A": -0.02, + "C": 1.08, + "D": -0.08, + "E": -0.13, + "F": 2.16, + "G": 0.09, + "H": 0.56, + "I": -0.08, + "K": -0.32, + "L": -0.08, + "M": 0.53, + "N": -0.3, + "P": -0.06, + "Q": -0.23, + "R": -0.71, + "S": -0.4, + "T": -0.24, + "V": -0.06, + "W": 1.78, + "Y": -0.91, + } + + # Normalized properties upto 3 decimal places + self.NP1 = {'A': 0.636, 'C': 0.298, 'D': -0.924, 'E': -0.759, 'F': 1.221, 'G': 0.493, 'H': -0.41, 'I': 1.416, 'K': -1.539, 'L': 1.088, 'M': 0.657, 'N': -0.8, 'P': 0.123, 'Q': -0.872, 'R': -2.596, 'S': -0.185, 'T': -0.051, 'V': 1.108, 'W': 0.831, 'Y': 0.267} + self.NP2 = {'A': -0.152, 'C': -0.418, 'D': 1.713, 'E': 1.713, 'F': -1.218, 'G': 0.115, 'H': -0.152, 'I': -0.845, 'K': 1.713, 'L': -0.845, 'M': -0.578, 'N': 0.221, 'P': 0.115, 'Q': 0.221, 'R': 1.713, 'S': 0.274, 'T': -0.099, 'V': -0.685, 'W': -1.697, 'Y': -1.111} + self.NP3 = {'A': -1.592, 'C': -0.53, 'D': -0.131, 'E': 0.334, 'F': 0.931, 'G': -2.057, 'H': 0.632, 'I': -0.198, 'K': 0.334, 'L': -0.198, 'M': 0.4, 'N': -0.164, 'P': -0.696, 'Q': 0.3, 'R': 1.263, 'S': -1.061, 'T': -0.596, 'V': -0.662, 'W': 2.226, 'Y': 1.462} + self.NP4 = {'A': 0.329, 'C': 1.417, 'D': -0.487, 'E': 1.417, 'F': -1.303, 'G': 0.057, 'H': -0.215, 'I': 1.036, 'K': 1.689, 'L': -0.922, 'M': -0.65, 'N': 0.166, 'P': -0.704, 'Q': 0.166, 'R': 1.689, 'S': 0.22, 'T': -0.16, 'V': -0.759, 'W': -1.792, 'Y': -1.194} + self.NP5 = {'A': 1.755, 'C': 0.429, 'D': -1.365, 'E': 0.195, 'F': -0.585, 'G': 1.365, 'H': -1.287, 'I': 0.039, 'K': 0.819, 'L': 1.287, 'M': -1.521, 'N': -0.039, 'P': -0.429, 'Q': -0.507, 'R': -0.351, 'S': 1.131, 'T': 0.507, 'V': 0.897, 'W': -1.755, 'Y': -0.585} + self.NP6 = {'A': -0.659, 'C': -1.007, 'D': 0.593, 'E': -1.633, 'F': 0.697, 'G': -0.416, 'H': -0.277, 'I': 1.671, 'K': -0.798, 'L': 0.836, 'M': 0.176, 'N': -1.32, 'P': -1.355, 'Q': -0.068, 'R': -0.52, 'S': -0.277, 'T': 0.628, 'V': 2.297, 'W': 0.628, 'Y': 0.802} + self.NP7 = {'A': 0.735, 'C': -0.968, 'D': 1.372, 'E': -1.341, 'F': 1.108, 'G': -0.023, 'H': -0.704, 'I': 1.273, 'K': -0.166, 'L': 1.141, 'M': 0.955, 'N': -0.924, 'P': -0.77, 'Q': -1.429, 'R': -1.924, 'S': -0.276, 'T': 0.021, 'V': 1.196, 'W': 0.746, 'Y': -0.023} + self.NP8 = {'A': 0.219, 'C': 1.552, 'D': -0.811, 'E': 0.69, 'F': -1.427, 'G': 0.575, 'H': -0.314, 'I': -1.42, 'K': 1.335, 'L': -1.554, 'M': -1.281, 'N': 1.087, 'P': 1.08, 'Q': 0.662, 'R': 0.212, 'S': 0.697, 'T': 0.686, 'V': -1.247, 'W': 0.117, 'Y': -0.857} + self.NP9 = {'A': 0.56, 'C': 1.13, 'D': -1.484, 'E': 2.509, 'F': -0.975, 'G': 0.933, 'H': -0.696, 'I': -0.722, 'K': 1.645, 'L': -0.181, 'M': -0.991, 'N': 0.158, 'P': -0.067, 'Q': 0.076, 'R': 0.592, 'S': 0.13, 'T': 0.114, 'V': -0.453, 'W': -1.411, 'Y': -0.867} + self.NP10 = {'A': -0.479, 'C': -0.663, 'D': 0.09, 'E': -0.654, 'F': 1.271, 'G': -1.153, 'H': -0.479, 'I': 1.516, 'K': 0.195, 'L': 0.658, 'M': 0.221, 'N': -1.161, 'P': 1.183, 'Q': -1.24, 'R': -0.496, 'S': -1.179, 'T': -1.179, 'V': 0.396, 'W': 2.058, 'Y': 1.096} + self.NP11 = {'A': 0.253, 'C': -0.338, 'D': -0.836, 'E': -0.061, 'F': -0.836, 'G': 0.548, 'H': -0.522, 'I': -0.541, 'K': 0.548, 'L': -0.947, 'M': -0.928, 'N': 0.345, 'P': 3.703, 'Q': -0.227, 'R': 0.031, 'S': 0.474, 'T': 0.696, 'V': -0.725, 'W': -0.614, 'Y': -0.024} + self.NP12 = {'A': -0.223, 'C': 1.256, 'D': -0.163, 'E': -0.042, 'F': -0.797, 'G': 1.588, 'H': -0.254, 'I': -1.008, 'K': -0.495, 'L': -1.189, 'M': -1.219, 'N': 1.98, 'P': 2.04, 'Q': -0.133, 'R': 0.048, 'S': 0.743, 'T': 0.169, 'V': -1.159, 'W': -0.948, 'Y': -0.193} + self.NP13 = {'A': -0.277, 'C': -1.356, 'D': 0.311, 'E': -1.037, 'F': 0.532, 'G': -1.037, 'H': -0.253, 'I': 1.905, 'K': -0.816, 'L': 0.655, 'M': 0.385, 'N': -1.062, 'P': -1.552, 'Q': -0.203, 'R': -0.253, 'S': -0.522, 'T': 0.213, 'V': 1.905, 'W': 1.243, 'Y': 1.219} + self.NP14 = {'A': -0.187, 'C': -0.393, 'D': 0.397, 'E': -2.352, 'F': 1.221, 'G': -0.393, 'H': -0.496, 'I': 1.805, 'K': -0.703, 'L': 0.843, 'M': 0.947, 'N': -1.012, 'P': -0.909, 'Q': 0.569, 'R': -1.184, 'S': -0.84, 'T': 0.74, 'V': 1.359, 'W': 0.397, 'Y': 0.191} + self.NP15 = {'A': -0.402, 'C': -1.503, 'D': 0.469, 'E': -1.119, 'F': 0.443, 'G': -1.273, 'H': 0.161, 'I': 1.237, 'K': -0.812, 'L': 0.52, 'M': 0.085, 'N': -1.119, 'P': -1.631, 'Q': 0.315, 'R': -0.095, 'S': -0.479, 'T': 0.622, 'V': 1.211, 'W': 1.775, 'Y': 1.595} + self.NP16 = {'A': -0.078, 'C': -0.667, 'D': -2.081, 'E': -0.562, 'F': -0.401, 'G': -0.097, 'H': 0.907, 'I': -0.066, 'K': 2.24, 'L': -0.091, 'M': -0.24, 'N': -0.444, 'P': 0.108, 'Q': -0.295, 'R': 2.872, 'S': -0.277, 'T': -0.289, 'V': -0.103, 'W': -0.147, 'Y': -0.289} + self.NP17 = {'A': 1.728, 'C': -0.604, 'D': -0.7, 'E': -1.671, 'F': -1.152, 'G': 1.25, 'H': -0.292, 'I': -0.273, 'K': -0.47, 'L': -0.273, 'M': -0.082, 'N': 0.008, 'P': 2.445, 'Q': -0.534, 'R': 1.371, 'S': 0.333, 'T': -0.097, 'V': 0.097, 'W': 0.218, 'Y': -1.302} + self.NP18 = {'A': -0.025, 'C': -1.322, 'D': -1.322, 'E': -1.249, 'F': 1.601, 'G': -0.81, 'H': -0.335, 'I': 1.291, 'K': -1.194, 'L': 1.382, 'M': 0.852, 'N': -0.847, 'P': 0.871, 'Q': -0.189, 'R': -0.993, 'S': -0.573, 'T': -0.098, 'V': 0.779, 'W': 1.273, 'Y': 0.907} + self.NP19 = {'A': 0.549, 'C': -1.863, 'D': 0.137, 'E': 0.173, 'F': -2.131, 'G': 0.111, 'H': 0.152, 'I': 0.131, 'K': 0.853, 'L': 0.147, 'M': -0.946, 'N': 1.167, 'P': 0.229, 'Q': 1.059, 'R': 2.172, 'S': 0.147, 'T': 0.126, 'V': 0.085, 'W': -1.116, 'Y': -1.183} + self.NP20 = {'A': -0.099, 'C': 1.717, 'D': -0.227, 'E': -0.277, 'F': 2.339, 'G': -0.385, 'H': 0.009, 'I': -0.223, 'K': -0.857, 'L': -0.231, 'M': 0.82, 'N': -1.081, 'P': -0.289, 'Q': -0.976, 'R': -1.996, 'S': -0.358, 'T': -0.281, 'V': -0.18, 'W': 1.431, 'Y': 1.145} + self.NP21 = {'A': -0.2, 'C': 1.276, 'D': -0.28, 'E': -0.348, 'F': 2.725, 'G': -0.052, 'H': 0.578, 'I': -0.28, 'K': -0.602, 'L': -0.28, 'M': 0.538, 'N': -0.576, 'P': -0.254, 'Q': -0.482, 'R': -1.126, 'S': -0.71, 'T': -0.495, 'V': -0.254, 'W': 2.215, 'Y': -1.394} + + # Define 7 selected groups of 3 properties each + self.prop_groups = [ + (self.NP1, self.NP2, self.NP3), + (self.NP4, self.NP5, self.NP6), + (self.NP7, self.NP8, self.NP9), + (self.NP10, self.NP11, self.NP12), + (self.NP13, self.NP14, self.NP15), + (self.NP16, self.NP17, self.NP18), + (self.NP19, self.NP20, self.NP21), + ] + + def _check_validity(self, seq): for aa in seq: if aa not in self.amino_acid: raise ValueError( @@ -522,72 +549,56 @@ def check_validity(self, seq): ) # Function to normalize amino acid composition - def normalize_aa(self, seq): + def _normalize_aa(self, seq): count = {aa: 0 for aa in self.amino_acid} for aa in seq: if aa in count: count[aa] += 1 - total = sum(count.values()) - return {aa: count[aa] / total if total > 0 else 0 for aa in count} + total = len(self.amino_acid) - # Normalize all physicochemical property dicts and store as a list - def normalize_properties(*property_dicts): - """ - Takes multiple amino acid property dictionaries and returns their normalized versions. - Normalization: (value - mean) / std deviation - Returns a list of normalized dictionaries in the same order. - """ - normalized = [] - for prop in property_dicts: - values = list(prop.values()) - mean_val = sum(values) / len(values) - std_val = (sum((v - mean_val) ** 2 for v in values) / len(values)) ** 0.5 - normalized.append( - {aa: (val - mean_val) / std_val for aa, val in prop.items()} - ) - return normalized + return {aa: count[aa] / total if total > 0 else 0 for aa in count} - def theta_RiRj(Ri, Rj, norm_props): + def _theta_RiRj(self, Ri, Rj, norm_props): return sum((prop[Rj] - prop[Ri]) ** 2 for prop in norm_props) / len(norm_props) - def sum_theta_val(seq, seq_len, LVal, n, norm_props): + def _sum_theta_val(self, seq, seq_len, LVal, n, norm_props): return sum( - theta_RiRj(seq[i], seq[i + n], norm_props) for i in range(seq_len - LVal) + self._theta_RiRj(seq[i], seq[i + n], norm_props) for i in range(seq_len - LVal) ) / (seq_len - n) - check_validity(self, protein_sequence) - - lambda_val = 30 - weight = 0.15 - all_pseaac = [] + def vectorize(self): + self._check_validity(self.protein_sequence) - if len(protein_sequence) <= lambda_val: - raise ValueError( - f"Sequence too short for Lambda={lambda_val}. Must be > {lambda_val}." - ) + lambda_val = 30 + weight = 0.15 + all_pseaac = [] - for group in prop_groups: - norm_props = normalize_properties(*group) - aa_freq = normalize_aa(self, protein_sequence) - sum_all_aa_freq = sum(aa_freq.values()) - - all_theta_val = [] - sum_all_theta_val = 0 - for n in range(1, lambda_val + 1): - theta_val = sum_theta_val( - protein_sequence, len(protein_sequence), lambda_val, n, norm_props + if len(self.protein_sequence) <= lambda_val: + raise ValueError( + f"Sequence too short for Lambda={lambda_val}. Must be > {lambda_val}." ) - all_theta_val.append(theta_val) - sum_all_theta_val += theta_val - denominator_val = sum_all_aa_freq + (weight * sum_all_theta_val) + for group in self.prop_groups: + aa_freq = self._normalize_aa(self.protein_sequence) + sum_all_aa_freq = sum(aa_freq.values()) + + all_theta_val = [] + sum_all_theta_val = 0 + for n in range(1, lambda_val + 1): + theta_val = self._sum_theta_val( + self.protein_sequence, len(self.protein_sequence), lambda_val, n, group + ) + all_theta_val.append(theta_val) + sum_all_theta_val += theta_val - # First 20 features: normalized amino acid composition - for aa in self.amino_acid: - all_pseaac.append(round((aa_freq[aa] / denominator_val), 3)) + denominator_val = sum_all_aa_freq + (weight * sum_all_theta_val) + print(f"Denominator value: {denominator_val}") + # First 20 features: normalized amino acid composition + for aa in self.amino_acid: + all_pseaac.append(round((aa_freq[aa] / denominator_val), 3)) - # Next 30 features: theta values - for theta_val in all_theta_val: - all_pseaac.append(round((weight * theta_val / denominator_val), 3)) + # Next 30 features: theta values + for theta_val in all_theta_val: + all_pseaac.append(round((weight * theta_val / denominator_val), 3)) - return all_pseaac + return all_pseaac \ No newline at end of file diff --git a/AptaNet/test_pseaac.py b/AptaNet/test_pseaac.py new file mode 100644 index 00000000..5306e9fa --- /dev/null +++ b/AptaNet/test_pseaac.py @@ -0,0 +1,416 @@ +from pseaac import PSeAAC + + +def _normalize_properties(property_dicts): + """ + Takes multiple amino acid property dictionaries and returns their normalized versions. + Normalization: (value - mean) / std deviation + Returns a list of normalized dictionaries in the same order. + """ + normalized = [] + for prop in property_dicts: + values = list(prop.values()) + mean_val = sum(values) / len(values) + std_val = (sum((v - mean_val) ** 2 for v in values) / len(values)) ** 0.5 + normalized.append( + {aa: round((val - mean_val) / std_val, 3) for aa, val in prop.items()} + ) + return normalized + + +# Test case for PSeAAC normalization +def test_normalized_values(): + apt = PSeAAC("ACDEFGHIKLMNPQRSTVWY") + # Collect all P properties from the instance + P_props = [getattr(apt, f"P{i}") for i in range(1, 21)] + # Normalize all P properties + normalized = _normalize_properties(P_props) + # Compare with NP properties + for i in range(1, 21): + np_dict = getattr(apt, f"NP{i}") + norm_dict = normalized[i - 1] + for aa in np_dict: + assert ( + np_dict[aa] == norm_dict[aa] + ), f"Mismatch in NP{i} for {aa}: {np_dict[aa]} != {norm_dict[aa]}" + +# Test case for PSeAAC vectorization +# def test_pseaac_vectorization(): +# x = "ACDFFKKIIKKLLMMNNPPQQQRRRRIIIIRRR" +# # Vector from the original PSeAAC implementation +# v = [0.012, 0.012, 0.012, 0.0, 0.025, 0.0, 0.0, 0.074, 0.05, 0.025, 0.025, 0.025, 0.025, 0.037, 0.087, 0.0, 0.0, 0.0, 0.0, 0.0, 0.008, 0.01, 0.005, 0.007, 0.014, 0.012, 0.002, 0.006, 0.016, 0.013, 0.007, 0.007, 0.005, 0.005, 0.007, 0.006, 0.003, 0.005, 0.01, 0.013, 0.028, 0.048, 0.053, 0.069, 0.055, 0.029, 0.034, 0.023, 0.074, 0.177, 0.016, 0.016, 0.016, 0.0, 0.031, 0.0, 0.0, 0.094, 0.063, 0.031, 0.031, 0.031, 0.031, 0.047, 0.11, 0.0, 0.0, 0.0, 0.0, 0.0, 0.007, 0.012, 0.017, 0.012, 0.005, 0.009, 0.017, 0.013, 0.007, 0.013, 0.01, 0.01, 0.022, 0.017, 0.009, 0.013, 0.013, 0.012, 0.012, 0.019, 0.018, 0.02, 0.022, 0.022, 0.038, 0.049, 0.057, 0.073, 0.066, 0.074, 0.012, 0.012, 0.012, 0.0, 0.025, 0.0, 0.0, 0.074, 0.05, 0.025, 0.025, 0.025, 0.025, 0.037, 0.087, 0.0, 0.0, 0.0, 0.0, 0.0, 0.009, 0.01, 0.016, 0.01, 0.002, 0.01, 0.018, 0.011, 0.003, 0.011, 0.011, 0.012, 0.02, 0.011, 0.01, 0.011, 0.014, 0.015, 0.017, 0.022, 0.025, 0.03, 0.033, 0.015, 0.039, 0.04, 0.047, 0.094, 0.074, 0.108, 0.019, 0.019, 0.019, 0.0, 0.039, 0.0, 0.0, 0.117, 0.078, 0.039, 0.039, 0.039, 0.039, 0.058, 0.136, 0.0, 0.0, 0.0, 0.0, 0.0, 0.004, 0.007, 0.01, 0.008, 0.006, 0.01, 0.013, 0.009, 0.005, 0.009, 0.011, 0.011, 0.017, 0.012, 0.036, 0.06, 0.051, 0.031, 0.007, 0.006, 0.006, 0.005, 0.006, 0.01, 0.031, 0.05, 0.058, 0.063, 0.039, 0.019, 0.015, 0.015, 0.015, 0.0, 0.031, 0.0, 0.0, 0.092, 0.061, 0.031, 0.031, 0.031, 0.031, 0.046, 0.107, 0.0, 0.0, 0.0, 0.0, 0.0, 0.005, 0.006, 0.009, 0.004, 0.004, 0.016, 0.023, 0.01, 0.001, 0.007, 0.009, 0.008, 0.012, 0.007, 0.01, 0.011, 0.004, 0.01, 0.008, 0.012, 0.01, 0.011, 0.012, 0.017, 0.056, 0.086, 0.101, 0.115, 0.07, 0.041, 0.009, 0.009, 0.009, 0.0, 0.018, 0.0, 0.0, 0.053, 0.035, 0.018, 0.018, 0.018, 0.018, 0.027, 0.062, 0.0, 0.0, 0.0, 0.0, 0.0, 0.006, 0.009, 0.011, 0.012, 0.01, 0.01, 0.011, 0.012, 0.012, 0.012, 0.009, 0.008, 0.006, 0.004, 0.012, 0.02, 0.011, 0.004, 0.007, 0.024, 0.037, 0.044, 0.049, 0.037, 0.031, 0.03, 0.036, 0.074, 0.113, 0.163, 0.011, 0.011, 0.011, 0.0, 0.021, 0.0, 0.0, 0.064, 0.043, 0.021, 0.021, 0.021, 0.021, 0.032, 0.075, 0.0, 0.0, 0.0, 0.0, 0.0, 0.014, 0.008, 0.009, 0.015, 0.007, 0.004, 0.005, 0.008, 0.008, 0.005, 0.007, 0.003, 0.004, 0.015, 0.013, 0.008, 0.008, 0.015, 0.016, 0.023, 0.04, 0.05, 0.054, 0.051, 0.023, 0.016, 0.018, 0.039, 0.118, 0.182] +# p = PSeAAC(x) +# print(p.vectorize()) +# assert len(p.vectorize()) == len(v), "Vector length mismatch" +# assert p.vectorize() == v, "Vector values mismatch" + +# Test case for PSeAAC vectorization +def test_pseaac_vectorization(): + x = "ACDFFKKIIKKLLMMNNPPQQQRRRRIIIIRRR" + v = [ + 0.012, + 0.012, + 0.012, + 0.0, + 0.025, + 0.0, + 0.0, + 0.074, + 0.05, + 0.025, + 0.025, + 0.025, + 0.025, + 0.037, + 0.087, + 0.0, + 0.0, + 0.0, + 0.0, + 0.0, + 0.008, + 0.01, + 0.005, + 0.007, + 0.014, + 0.012, + 0.002, + 0.006, + 0.016, + 0.013, + 0.007, + 0.007, + 0.005, + 0.005, + 0.007, + 0.006, + 0.003, + 0.005, + 0.01, + 0.013, + 0.028, + 0.048, + 0.053, + 0.069, + 0.055, + 0.029, + 0.034, + 0.023, + 0.074, + 0.177, + 0.016, + 0.016, + 0.016, + 0.0, + 0.031, + 0.0, + 0.0, + 0.094, + 0.063, + 0.031, + 0.031, + 0.031, + 0.031, + 0.047, + 0.11, + 0.0, + 0.0, + 0.0, + 0.0, + 0.0, + 0.007, + 0.012, + 0.017, + 0.012, + 0.005, + 0.009, + 0.017, + 0.013, + 0.007, + 0.013, + 0.01, + 0.01, + 0.022, + 0.017, + 0.009, + 0.013, + 0.013, + 0.012, + 0.012, + 0.019, + 0.018, + 0.02, + 0.022, + 0.022, + 0.038, + 0.049, + 0.057, + 0.073, + 0.066, + 0.074, + 0.012, + 0.012, + 0.012, + 0.0, + 0.025, + 0.0, + 0.0, + 0.074, + 0.05, + 0.025, + 0.025, + 0.025, + 0.025, + 0.037, + 0.087, + 0.0, + 0.0, + 0.0, + 0.0, + 0.0, + 0.009, + 0.01, + 0.016, + 0.01, + 0.002, + 0.01, + 0.018, + 0.011, + 0.003, + 0.011, + 0.011, + 0.012, + 0.02, + 0.011, + 0.01, + 0.011, + 0.014, + 0.015, + 0.017, + 0.022, + 0.025, + 0.03, + 0.033, + 0.015, + 0.039, + 0.04, + 0.047, + 0.094, + 0.074, + 0.108, + 0.019, + 0.019, + 0.019, + 0.0, + 0.039, + 0.0, + 0.0, + 0.117, + 0.078, + 0.039, + 0.039, + 0.039, + 0.039, + 0.058, + 0.136, + 0.0, + 0.0, + 0.0, + 0.0, + 0.0, + 0.004, + 0.007, + 0.01, + 0.008, + 0.006, + 0.01, + 0.013, + 0.009, + 0.005, + 0.009, + 0.011, + 0.011, + 0.017, + 0.012, + 0.036, + 0.06, + 0.051, + 0.031, + 0.007, + 0.006, + 0.006, + 0.005, + 0.006, + 0.01, + 0.031, + 0.05, + 0.058, + 0.063, + 0.039, + 0.019, + 0.015, + 0.015, + 0.015, + 0.0, + 0.031, + 0.0, + 0.0, + 0.092, + 0.061, + 0.031, + 0.031, + 0.031, + 0.031, + 0.046, + 0.107, + 0.0, + 0.0, + 0.0, + 0.0, + 0.0, + 0.005, + 0.006, + 0.009, + 0.004, + 0.004, + 0.016, + 0.023, + 0.01, + 0.001, + 0.007, + 0.009, + 0.008, + 0.012, + 0.007, + 0.01, + 0.011, + 0.004, + 0.01, + 0.008, + 0.012, + 0.01, + 0.011, + 0.012, + 0.017, + 0.056, + 0.086, + 0.101, + 0.115, + 0.07, + 0.041, + 0.009, + 0.009, + 0.009, + 0.0, + 0.018, + 0.0, + 0.0, + 0.053, + 0.035, + 0.018, + 0.018, + 0.018, + 0.018, + 0.027, + 0.062, + 0.0, + 0.0, + 0.0, + 0.0, + 0.0, + 0.006, + 0.009, + 0.011, + 0.012, + 0.01, + 0.01, + 0.011, + 0.012, + 0.012, + 0.012, + 0.009, + 0.008, + 0.006, + 0.004, + 0.012, + 0.02, + 0.011, + 0.004, + 0.007, + 0.024, + 0.037, + 0.044, + 0.049, + 0.037, + 0.031, + 0.03, + 0.036, + 0.074, + 0.113, + 0.163, + 0.011, + 0.011, + 0.011, + 0.0, + 0.021, + 0.0, + 0.0, + 0.064, + 0.043, + 0.021, + 0.021, + 0.021, + 0.021, + 0.032, + 0.075, + 0.0, + 0.0, + 0.0, + 0.0, + 0.0, + 0.014, + 0.008, + 0.009, + 0.015, + 0.007, + 0.004, + 0.005, + 0.008, + 0.008, + 0.005, + 0.007, + 0.003, + 0.004, + 0.015, + 0.013, + 0.008, + 0.008, + 0.015, + 0.016, + 0.023, + 0.04, + 0.05, + 0.054, + 0.051, + 0.023, + 0.016, + 0.018, + 0.039, + 0.118, + 0.182, + ] + p = PSeAAC(x) + pv = p.vectorize() + assert len(pv) == len(v), f"Vector length mismatch: {len(pv)} != {len(v)}" + mismatches = [] + for i, (a, b) in enumerate(zip(pv, v)): + if a != b: + mismatches.append((i, a, b)) + if mismatches: + print("Mismatched indices and values:") + for idx, a, b in mismatches: + print(f"Index {idx}: vectorize()={a}, expected={b}") + assert not mismatches, f"Vector values mismatch at indices: {mismatches}" + + +test_pseaac_vectorization() From 3773a901e727998c4d0c2735b7a65cf5cd042ab3 Mon Sep 17 00:00:00 2001 From: satvshr Date: Tue, 8 Jul 2025 03:02:44 +0530 Subject: [PATCH 004/145] Made a few readability changes --- AptaNet/pseaac.py | 18 +++++++++--------- AptaNet/test_pseaac.py | 17 ++++++----------- 2 files changed, 15 insertions(+), 20 deletions(-) diff --git a/AptaNet/pseaac.py b/AptaNet/pseaac.py index c0d0b16a..fcb9fb7d 100644 --- a/AptaNet/pseaac.py +++ b/AptaNet/pseaac.py @@ -548,8 +548,8 @@ def _check_validity(self, seq): f"Invalid amino acid '{aa}' found in protein_sequence. Only {self.amino_acid} are allowed." ) - # Function to normalize amino acid composition - def _normalize_aa(self, seq): + # Function to average the amino acid composition + def _average_aa(self, seq): count = {aa: 0 for aa in self.amino_acid} for aa in seq: if aa in count: @@ -558,12 +558,12 @@ def _normalize_aa(self, seq): return {aa: count[aa] / total if total > 0 else 0 for aa in count} - def _theta_RiRj(self, Ri, Rj, norm_props): - return sum((prop[Rj] - prop[Ri]) ** 2 for prop in norm_props) / len(norm_props) + def _theta_RiRj(self, Ri, Rj, prop_group): + return sum((prop[Rj] - prop[Ri]) ** 2 for prop in prop_group) / len(prop_group) - def _sum_theta_val(self, seq, seq_len, LVal, n, norm_props): + def _sum_theta_val(self, seq, seq_len, lambda_val, n, prop_group): return sum( - self._theta_RiRj(seq[i], seq[i + n], norm_props) for i in range(seq_len - LVal) + self._theta_RiRj(seq[i], seq[i + n], prop_group) for i in range(seq_len - lambda_val) ) / (seq_len - n) def vectorize(self): @@ -578,15 +578,15 @@ def vectorize(self): f"Sequence too short for Lambda={lambda_val}. Must be > {lambda_val}." ) - for group in self.prop_groups: - aa_freq = self._normalize_aa(self.protein_sequence) + for prop_group in self.prop_groups: + aa_freq = self._average_aa(self.protein_sequence) sum_all_aa_freq = sum(aa_freq.values()) all_theta_val = [] sum_all_theta_val = 0 for n in range(1, lambda_val + 1): theta_val = self._sum_theta_val( - self.protein_sequence, len(self.protein_sequence), lambda_val, n, group + self.protein_sequence, len(self.protein_sequence), lambda_val, n, prop_group ) all_theta_val.append(theta_val) sum_all_theta_val += theta_val diff --git a/AptaNet/test_pseaac.py b/AptaNet/test_pseaac.py index 5306e9fa..cfaf2766 100644 --- a/AptaNet/test_pseaac.py +++ b/AptaNet/test_pseaac.py @@ -1,5 +1,5 @@ from pseaac import PSeAAC - +import numpy as np def _normalize_properties(property_dicts): """ @@ -401,16 +401,11 @@ def test_pseaac_vectorization(): ] p = PSeAAC(x) pv = p.vectorize() + assert len(pv) == len(v), f"Vector length mismatch: {len(pv)} != {len(v)}" - mismatches = [] - for i, (a, b) in enumerate(zip(pv, v)): - if a != b: - mismatches.append((i, a, b)) - if mismatches: - print("Mismatched indices and values:") - for idx, a, b in mismatches: - print(f"Index {idx}: vectorize()={a}, expected={b}") - assert not mismatches, f"Vector values mismatch at indices: {mismatches}" + if not np.allclose(pv, v, atol=1e-3): + mismatches = [(i, a, b) for i, (a, b) in enumerate(zip(pv, v)) if not np.isclose(a, b, atol=1e-3)] + raise AssertionError(f"Vector values mismatch at indices: {mismatches}") -test_pseaac_vectorization() +test_pseaac_vectorization() \ No newline at end of file From 9b9a3dad5601a69c7730bd6e2167a7b3923c6ad9 Mon Sep 17 00:00:00 2001 From: satvshr Date: Tue, 8 Jul 2025 12:55:28 +0530 Subject: [PATCH 005/145] Edited tests --- AptaNet/test_pseaac.py | 3 --- 1 file changed, 3 deletions(-) diff --git a/AptaNet/test_pseaac.py b/AptaNet/test_pseaac.py index cfaf2766..5dce177f 100644 --- a/AptaNet/test_pseaac.py +++ b/AptaNet/test_pseaac.py @@ -21,11 +21,8 @@ def _normalize_properties(property_dicts): # Test case for PSeAAC normalization def test_normalized_values(): apt = PSeAAC("ACDEFGHIKLMNPQRSTVWY") - # Collect all P properties from the instance P_props = [getattr(apt, f"P{i}") for i in range(1, 21)] - # Normalize all P properties normalized = _normalize_properties(P_props) - # Compare with NP properties for i in range(1, 21): np_dict = getattr(apt, f"NP{i}") norm_dict = normalized[i - 1] From 2dfe0c754eb4561519a5039e6c8cced21c453389 Mon Sep 17 00:00:00 2001 From: satvshr Date: Tue, 8 Jul 2025 17:02:40 +0530 Subject: [PATCH 006/145] Added pytest to tests --- AptaNet/test_pseaac.py | 44 ++++++++++++++++-------------------------- 1 file changed, 17 insertions(+), 27 deletions(-) diff --git a/AptaNet/test_pseaac.py b/AptaNet/test_pseaac.py index 5dce177f..a1b645e0 100644 --- a/AptaNet/test_pseaac.py +++ b/AptaNet/test_pseaac.py @@ -1,5 +1,6 @@ -from pseaac import PSeAAC import numpy as np +import pytest +from pseaac import PSeAAC def _normalize_properties(property_dicts): """ @@ -17,8 +18,6 @@ def _normalize_properties(property_dicts): ) return normalized - -# Test case for PSeAAC normalization def test_normalized_values(): apt = PSeAAC("ACDEFGHIKLMNPQRSTVWY") P_props = [getattr(apt, f"P{i}") for i in range(1, 21)] @@ -27,24 +26,13 @@ def test_normalized_values(): np_dict = getattr(apt, f"NP{i}") norm_dict = normalized[i - 1] for aa in np_dict: - assert ( - np_dict[aa] == norm_dict[aa] - ), f"Mismatch in NP{i} for {aa}: {np_dict[aa]} != {norm_dict[aa]}" + assert np_dict[aa] == norm_dict[aa], f"Mismatch in NP{i} for {aa}: {np_dict[aa]} != {norm_dict[aa]}" -# Test case for PSeAAC vectorization -# def test_pseaac_vectorization(): -# x = "ACDFFKKIIKKLLMMNNPPQQQRRRRIIIIRRR" -# # Vector from the original PSeAAC implementation -# v = [0.012, 0.012, 0.012, 0.0, 0.025, 0.0, 0.0, 0.074, 0.05, 0.025, 0.025, 0.025, 0.025, 0.037, 0.087, 0.0, 0.0, 0.0, 0.0, 0.0, 0.008, 0.01, 0.005, 0.007, 0.014, 0.012, 0.002, 0.006, 0.016, 0.013, 0.007, 0.007, 0.005, 0.005, 0.007, 0.006, 0.003, 0.005, 0.01, 0.013, 0.028, 0.048, 0.053, 0.069, 0.055, 0.029, 0.034, 0.023, 0.074, 0.177, 0.016, 0.016, 0.016, 0.0, 0.031, 0.0, 0.0, 0.094, 0.063, 0.031, 0.031, 0.031, 0.031, 0.047, 0.11, 0.0, 0.0, 0.0, 0.0, 0.0, 0.007, 0.012, 0.017, 0.012, 0.005, 0.009, 0.017, 0.013, 0.007, 0.013, 0.01, 0.01, 0.022, 0.017, 0.009, 0.013, 0.013, 0.012, 0.012, 0.019, 0.018, 0.02, 0.022, 0.022, 0.038, 0.049, 0.057, 0.073, 0.066, 0.074, 0.012, 0.012, 0.012, 0.0, 0.025, 0.0, 0.0, 0.074, 0.05, 0.025, 0.025, 0.025, 0.025, 0.037, 0.087, 0.0, 0.0, 0.0, 0.0, 0.0, 0.009, 0.01, 0.016, 0.01, 0.002, 0.01, 0.018, 0.011, 0.003, 0.011, 0.011, 0.012, 0.02, 0.011, 0.01, 0.011, 0.014, 0.015, 0.017, 0.022, 0.025, 0.03, 0.033, 0.015, 0.039, 0.04, 0.047, 0.094, 0.074, 0.108, 0.019, 0.019, 0.019, 0.0, 0.039, 0.0, 0.0, 0.117, 0.078, 0.039, 0.039, 0.039, 0.039, 0.058, 0.136, 0.0, 0.0, 0.0, 0.0, 0.0, 0.004, 0.007, 0.01, 0.008, 0.006, 0.01, 0.013, 0.009, 0.005, 0.009, 0.011, 0.011, 0.017, 0.012, 0.036, 0.06, 0.051, 0.031, 0.007, 0.006, 0.006, 0.005, 0.006, 0.01, 0.031, 0.05, 0.058, 0.063, 0.039, 0.019, 0.015, 0.015, 0.015, 0.0, 0.031, 0.0, 0.0, 0.092, 0.061, 0.031, 0.031, 0.031, 0.031, 0.046, 0.107, 0.0, 0.0, 0.0, 0.0, 0.0, 0.005, 0.006, 0.009, 0.004, 0.004, 0.016, 0.023, 0.01, 0.001, 0.007, 0.009, 0.008, 0.012, 0.007, 0.01, 0.011, 0.004, 0.01, 0.008, 0.012, 0.01, 0.011, 0.012, 0.017, 0.056, 0.086, 0.101, 0.115, 0.07, 0.041, 0.009, 0.009, 0.009, 0.0, 0.018, 0.0, 0.0, 0.053, 0.035, 0.018, 0.018, 0.018, 0.018, 0.027, 0.062, 0.0, 0.0, 0.0, 0.0, 0.0, 0.006, 0.009, 0.011, 0.012, 0.01, 0.01, 0.011, 0.012, 0.012, 0.012, 0.009, 0.008, 0.006, 0.004, 0.012, 0.02, 0.011, 0.004, 0.007, 0.024, 0.037, 0.044, 0.049, 0.037, 0.031, 0.03, 0.036, 0.074, 0.113, 0.163, 0.011, 0.011, 0.011, 0.0, 0.021, 0.0, 0.0, 0.064, 0.043, 0.021, 0.021, 0.021, 0.021, 0.032, 0.075, 0.0, 0.0, 0.0, 0.0, 0.0, 0.014, 0.008, 0.009, 0.015, 0.007, 0.004, 0.005, 0.008, 0.008, 0.005, 0.007, 0.003, 0.004, 0.015, 0.013, 0.008, 0.008, 0.015, 0.016, 0.023, 0.04, 0.05, 0.054, 0.051, 0.023, 0.016, 0.018, 0.039, 0.118, 0.182] -# p = PSeAAC(x) -# print(p.vectorize()) -# assert len(p.vectorize()) == len(v), "Vector length mismatch" -# assert p.vectorize() == v, "Vector values mismatch" -# Test case for PSeAAC vectorization -def test_pseaac_vectorization(): - x = "ACDFFKKIIKKLLMMNNPPQQQRRRRIIIIRRR" - v = [ +@pytest.mark.parametrize("seq,expected_vector", [ + ( + "ACDFFKKIIKKLLMMNNPPQQQRRRRIIIIRRR", + [ 0.012, 0.012, 0.012, @@ -396,13 +384,15 @@ def test_pseaac_vectorization(): 0.118, 0.182, ] - p = PSeAAC(x) + ) +]) +def test_pseaac_vectorization(seq, expected_vector): + p = PSeAAC(seq) pv = p.vectorize() - assert len(pv) == len(v), f"Vector length mismatch: {len(pv)} != {len(v)}" - - if not np.allclose(pv, v, atol=1e-3): - mismatches = [(i, a, b) for i, (a, b) in enumerate(zip(pv, v)) if not np.isclose(a, b, atol=1e-3)] - raise AssertionError(f"Vector values mismatch at indices: {mismatches}") - -test_pseaac_vectorization() \ No newline at end of file + assert len(pv) == len(expected_vector), f"Vector length mismatch: {len(pv)} != {len(expected_vector)}" + mismatches = [ + (i, a, b) for i, (a, b) in enumerate(zip(pv, expected_vector)) + if not np.isclose(a, b, atol=1e-3) + ] + assert not mismatches, f"Vector values mismatch at indices: {mismatches}" \ No newline at end of file From 1e182d35b4f86499a3044280643f32ac68c5dd81 Mon Sep 17 00:00:00 2001 From: satvshr Date: Wed, 9 Jul 2025 01:25:28 +0530 Subject: [PATCH 007/145] Added numpy style docstrings and ruff formatting --- pyaptamer/AptaNet/pseaac.py | 1139 ++++++++++++++++++++++++++++++ pyaptamer/AptaNet/test_pseaac.py | 429 +++++++++++ 2 files changed, 1568 insertions(+) create mode 100644 pyaptamer/AptaNet/pseaac.py create mode 100644 pyaptamer/AptaNet/test_pseaac.py diff --git a/pyaptamer/AptaNet/pseaac.py b/pyaptamer/AptaNet/pseaac.py new file mode 100644 index 00000000..90c10e4b --- /dev/null +++ b/pyaptamer/AptaNet/pseaac.py @@ -0,0 +1,1139 @@ +class PSeAAC: + """ + Compute Pseudo Amino Acid Composition (PseAAC) features for a protein sequence. + + Parameters + ---------- + protein_sequence : str + Protein sequence using single-letter amino acid codes. + """ + + def __init__(self, protein_sequence): + """ + Initialize PSeAAC with a protein sequence. + + Parameters + ---------- + protein_sequence : str + Protein sequence using single-letter amino acid codes. + """ + self.protein_sequence = protein_sequence + self.amino_acid = list("ACDEFGHIKLMNPQRSTVWY") + + # The hydrophobicity values are from JACS, 1962, 84: 4240-4246. (C. Tanford). + self.P1 = { + "A": 0.62, + "C": 0.29, + "D": -0.90, + "E": -0.74, + "F": 1.19, + "G": 0.48, + "H": -0.40, + "I": 1.38, + "K": -1.50, + "L": 1.06, + "M": 0.64, + "N": -0.78, + "P": 0.12, + "Q": -0.85, + "R": -2.53, + "S": -0.18, + "T": -0.05, + "V": 1.08, + "W": 0.81, + "Y": 0.26, + } + + # The hydrophilicity values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods). + self.P2 = { + "A": -0.5, + "C": -1.0, + "D": 3.0, + "E": 3.0, + "F": -2.5, + "G": 0.0, + "H": -0.5, + "I": -1.8, + "K": 3.0, + "L": -1.8, + "M": -1.3, + "N": 0.2, + "P": 0.0, + "Q": 0.2, + "R": 3.0, + "S": 0.3, + "T": -0.4, + "V": -1.5, + "W": -3.4, + "Y": -2.3, + } + + # The side-chain mass for each of the 20 amino acids. + self.P3 = { + "A": 15.0, + "C": 47.0, + "D": 59.0, + "E": 73.0, + "F": 91.0, + "G": 1.0, + "H": 82.0, + "I": 57.0, + "K": 73.0, + "L": 57.0, + "M": 75.0, + "N": 58.0, + "P": 42.0, + "Q": 72.0, + "R": 101.0, + "S": 31.0, + "T": 45.0, + "V": 43.0, + "W": 130.0, + "Y": 107.0, + } + + # The Polarity values are from JACS, 1962, 84: 4240-4246. (C. Tanford). + self.P4 = { + "A": 0.5, + "C": 2.5, + "D": -1, + "E": 2.5, + "F": -2.5, + "G": 0, + "H": -0.5, + "I": 1.8, + "K": 3, + "L": -1.8, + "M": -1.3, + "N": 0.2, + "P": -1.4, + "Q": 0.2, + "R": 3, + "S": 0.3, + "T": -0.4, + "V": -1.5, + "W": -3.4, + "Y": -2.3, + } + + # The Molecular weight values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods). + self.P5 = { + "A": 5.3, + "C": 3.6, + "D": 1.3, + "E": 3.3, + "F": 2.3, + "G": 4.8, + "H": 1.4, + "I": 3.1, + "K": 4.1, + "L": 4.7, + "M": 1.1, + "N": 3, + "P": 2.5, + "Q": 2.4, + "R": 2.6, + "S": 4.5, + "T": 3.7, + "V": 4.2, + "W": 0.8, + "Y": 2.3, + } + + # The Meling point for each of the 20 amino acids. + self.P6 = { + "A": 0.81, + "C": 0.71, + "D": 1.17, + "E": 0.53, + "F": 1.2, + "G": 0.88, + "H": 0.92, + "I": 1.48, + "K": 0.77, + "L": 1.24, + "M": 1.05, + "N": 0.62, + "P": 0.61, + "Q": 0.98, + "R": 0.85, + "S": 0.92, + "T": 1.18, + "V": 1.66, + "W": 1.18, + "Y": 1.23, + } + + # The Transfer_free_energy values are from JACS, 1962, 84: 4240-4246. (C. Tanford). + self.P7 = { + "A": 58, + "C": -97, + "D": 116, + "E": -131, + "F": 92, + "G": -11, + "H": -73, + "I": 107, + "K": -24, + "L": 95, + "M": 78, + "N": -93, + "P": -79, + "Q": -139, + "R": -184, + "S": -34, + "T": -7, + "V": 100, + "W": 59, + "Y": -11, + } + + # The Buriability values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods). + self.P8 = { + "A": 1.37, + "C": 8.93, + "D": -4.47, + "E": 4.04, + "F": -7.96, + "G": 3.39, + "H": -1.65, + "I": -7.92, + "K": 7.7, + "L": -8.68, + "M": -7.13, + "N": 6.29, + "P": 6.25, + "Q": 3.88, + "R": 1.33, + "S": 4.08, + "T": 4.02, + "V": -6.94, + "W": 0.79, + "Y": -4.73, + } + + # The Bulkiness for each of the 20 amino acids. + self.P9 = { + "A": 6.77, + "C": 8.57, + "D": 0.31, + "E": 12.93, + "F": 1.92, + "G": 7.95, + "H": 2.8, + "I": 2.72, + "K": 10.2, + "L": 4.43, + "M": 1.87, + "N": 5.5, + "P": 4.79, + "Q": 5.24, + "R": 6.87, + "S": 5.41, + "T": 5.36, + "V": 3.57, + "W": 0.54, + "Y": 2.26, + } + + # The Solvation_free_energy values are from JACS, 1962, 84: 4240-4246. (C. Tanford). + self.P10 = { + "A": 0.87, + "C": 0.66, + "D": 1.52, + "E": 0.67, + "F": 2.87, + "G": 0.1, + "H": 0.87, + "I": 3.15, + "K": 1.64, + "L": 2.17, + "M": 1.67, + "N": 0.09, + "P": 2.77, + "Q": 0, + "R": 0.85, + "S": 0.07, + "T": 0.07, + "V": 1.87, + "W": 3.77, + "Y": 2.67, + } + + # The Relative_mutability values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods). + self.P11 = { + "A": 1.09, + "C": 0.77, + "D": 0.5, + "E": 0.92, + "F": 0.5, + "G": 1.25, + "H": 0.67, + "I": 0.66, + "K": 1.25, + "L": 0.44, + "M": 0.45, + "N": 1.14, + "P": 2.96, + "Q": 0.83, + "R": 0.97, + "S": 1.21, + "T": 1.33, + "V": 0.56, + "W": 0.62, + "Y": 0.94, + } + + # The Residue_volume for each of the 20 amino acids. + self.P12 = { + "A": 0.91, + "C": 1.4, + "D": 0.93, + "E": 0.97, + "F": 0.72, + "G": 1.51, + "H": 0.9, + "I": 0.65, + "K": 0.82, + "L": 0.59, + "M": 0.58, + "N": 1.64, + "P": 1.66, + "Q": 0.94, + "R": 1, + "S": 1.23, + "T": 1.04, + "V": 0.6, + "W": 0.67, + "Y": 0.92, + } + + # The volume values are from JACS, 1962, 84: 4240-4246. (C. Tanford). + self.P13 = { + "A": 0.92, + "C": 0.48, + "D": 1.16, + "E": 0.61, + "F": 1.25, + "G": 0.61, + "H": 0.93, + "I": 1.81, + "K": 0.7, + "L": 1.3, + "M": 1.19, + "N": 0.6, + "P": 0.4, + "Q": 0.95, + "R": 0.93, + "S": 0.82, + "T": 1.12, + "V": 1.81, + "W": 1.54, + "Y": 1.53, + } + + # The Amino_acid_distribution values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods). + self.P14 = { + "A": 0.96, + "C": 0.9, + "D": 1.13, + "E": 0.33, + "F": 1.37, + "G": 0.9, + "H": 0.87, + "I": 1.54, + "K": 0.81, + "L": 1.26, + "M": 1.29, + "N": 0.72, + "P": 0.75, + "Q": 1.18, + "R": 0.67, + "S": 0.77, + "T": 1.23, + "V": 1.41, + "W": 1.13, + "Y": 1.07, + } + + # The Hydration_number for each of the 20 amino acids. + self.P15 = { + "A": 0.9, + "C": 0.47, + "D": 1.24, + "E": 0.62, + "F": 1.23, + "G": 0.56, + "H": 1.12, + "I": 1.54, + "K": 0.74, + "L": 1.26, + "M": 1.09, + "N": 0.62, + "P": 0.42, + "Q": 1.18, + "R": 1.02, + "S": 0.87, + "T": 1.3, + "V": 1.53, + "W": 1.75, + "Y": 1.68, + } + + # The Isoelectric_point values are from JACS, 1962, 84: 4240-4246. (C. Tanford). + self.P16 = { + "A": 6, + "C": 5.05, + "D": 2.77, + "E": 5.22, + "F": 5.48, + "G": 5.97, + "H": 7.59, + "I": 6.02, + "K": 9.74, + "L": 5.98, + "M": 5.74, + "N": 5.41, + "P": 6.3, + "Q": 5.65, + "R": 10.76, + "S": 5.68, + "T": 5.66, + "V": 5.96, + "W": 5.89, + "Y": 5.66, + } + + # The Compressibility values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods). + self.P17 = { + "A": -25.5, + "C": -32.82, + "D": -33.12, + "E": -36.17, + "F": -34.54, + "G": -27, + "H": -31.84, + "I": -31.78, + "K": -32.4, + "L": -31.78, + "M": -31.18, + "N": -30.9, + "P": -23.25, + "Q": -32.6, + "R": -26.62, + "S": -29.88, + "T": -31.23, + "V": -30.62, + "W": -30.24, + "Y": -35.01, + } + + # The Chromatographic_index for each of the 20 amino acids. + self.P18 = { + "A": 9.9, + "C": 2.8, + "D": 2.8, + "E": 3.2, + "F": 18.8, + "G": 5.6, + "H": 8.2, + "I": 17.1, + "K": 3.5, + "L": 17.6, + "M": 14.7, + "N": 5.4, + "P": 14.8, + "Q": 9, + "R": 4.6, + "S": 6.9, + "T": 9.5, + "V": 14.3, + "W": 17, + "Y": 15, + } + + # The Unfolding_entropy_change values are from JACS, 1962, 84: 4240-4246. (C. Tanford). + self.P19 = { + "A": 0.54, + "C": -4.14, + "D": -0.26, + "E": -0.19, + "F": -4.66, + "G": -0.31, + "H": -0.23, + "I": -0.27, + "K": 1.13, + "L": -0.24, + "M": -2.36, + "N": 1.74, + "P": -0.08, + "Q": 1.53, + "R": 3.69, + "S": -0.24, + "T": -0.28, + "V": -0.36, + "W": -2.69, + "Y": -2.82, + } + + # The Unfolding_entalpy_change values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods). + self.P20 = { + "A": 0.51, + "C": 5.21, + "D": 0.18, + "E": 0.05, + "F": 6.82, + "G": -0.23, + "H": 0.79, + "I": 0.19, + "K": -1.45, + "L": 0.17, + "M": 2.89, + "N": -2.03, + "P": 0.02, + "Q": -1.76, + "R": -4.4, + "S": -0.16, + "T": 0.04, + "V": 0.3, + "W": 4.47, + "Y": 3.73, + } + + # The Unfolding_Gibbs_free_energy_change for each of the 20 amino acids. + self.P21 = { + "A": -0.02, + "C": 1.08, + "D": -0.08, + "E": -0.13, + "F": 2.16, + "G": 0.09, + "H": 0.56, + "I": -0.08, + "K": -0.32, + "L": -0.08, + "M": 0.53, + "N": -0.3, + "P": -0.06, + "Q": -0.23, + "R": -0.71, + "S": -0.4, + "T": -0.24, + "V": -0.06, + "W": 1.78, + "Y": -0.91, + } + + # Normalized properties upto 3 decimal places + self.NP1 = { + "A": 0.636, + "C": 0.298, + "D": -0.924, + "E": -0.759, + "F": 1.221, + "G": 0.493, + "H": -0.41, + "I": 1.416, + "K": -1.539, + "L": 1.088, + "M": 0.657, + "N": -0.8, + "P": 0.123, + "Q": -0.872, + "R": -2.596, + "S": -0.185, + "T": -0.051, + "V": 1.108, + "W": 0.831, + "Y": 0.267, + } + self.NP2 = { + "A": -0.152, + "C": -0.418, + "D": 1.713, + "E": 1.713, + "F": -1.218, + "G": 0.115, + "H": -0.152, + "I": -0.845, + "K": 1.713, + "L": -0.845, + "M": -0.578, + "N": 0.221, + "P": 0.115, + "Q": 0.221, + "R": 1.713, + "S": 0.274, + "T": -0.099, + "V": -0.685, + "W": -1.697, + "Y": -1.111, + } + self.NP3 = { + "A": -1.592, + "C": -0.53, + "D": -0.131, + "E": 0.334, + "F": 0.931, + "G": -2.057, + "H": 0.632, + "I": -0.198, + "K": 0.334, + "L": -0.198, + "M": 0.4, + "N": -0.164, + "P": -0.696, + "Q": 0.3, + "R": 1.263, + "S": -1.061, + "T": -0.596, + "V": -0.662, + "W": 2.226, + "Y": 1.462, + } + self.NP4 = { + "A": 0.329, + "C": 1.417, + "D": -0.487, + "E": 1.417, + "F": -1.303, + "G": 0.057, + "H": -0.215, + "I": 1.036, + "K": 1.689, + "L": -0.922, + "M": -0.65, + "N": 0.166, + "P": -0.704, + "Q": 0.166, + "R": 1.689, + "S": 0.22, + "T": -0.16, + "V": -0.759, + "W": -1.792, + "Y": -1.194, + } + self.NP5 = { + "A": 1.755, + "C": 0.429, + "D": -1.365, + "E": 0.195, + "F": -0.585, + "G": 1.365, + "H": -1.287, + "I": 0.039, + "K": 0.819, + "L": 1.287, + "M": -1.521, + "N": -0.039, + "P": -0.429, + "Q": -0.507, + "R": -0.351, + "S": 1.131, + "T": 0.507, + "V": 0.897, + "W": -1.755, + "Y": -0.585, + } + self.NP6 = { + "A": -0.659, + "C": -1.007, + "D": 0.593, + "E": -1.633, + "F": 0.697, + "G": -0.416, + "H": -0.277, + "I": 1.671, + "K": -0.798, + "L": 0.836, + "M": 0.176, + "N": -1.32, + "P": -1.355, + "Q": -0.068, + "R": -0.52, + "S": -0.277, + "T": 0.628, + "V": 2.297, + "W": 0.628, + "Y": 0.802, + } + self.NP7 = { + "A": 0.735, + "C": -0.968, + "D": 1.372, + "E": -1.341, + "F": 1.108, + "G": -0.023, + "H": -0.704, + "I": 1.273, + "K": -0.166, + "L": 1.141, + "M": 0.955, + "N": -0.924, + "P": -0.77, + "Q": -1.429, + "R": -1.924, + "S": -0.276, + "T": 0.021, + "V": 1.196, + "W": 0.746, + "Y": -0.023, + } + self.NP8 = { + "A": 0.219, + "C": 1.552, + "D": -0.811, + "E": 0.69, + "F": -1.427, + "G": 0.575, + "H": -0.314, + "I": -1.42, + "K": 1.335, + "L": -1.554, + "M": -1.281, + "N": 1.087, + "P": 1.08, + "Q": 0.662, + "R": 0.212, + "S": 0.697, + "T": 0.686, + "V": -1.247, + "W": 0.117, + "Y": -0.857, + } + self.NP9 = { + "A": 0.56, + "C": 1.13, + "D": -1.484, + "E": 2.509, + "F": -0.975, + "G": 0.933, + "H": -0.696, + "I": -0.722, + "K": 1.645, + "L": -0.181, + "M": -0.991, + "N": 0.158, + "P": -0.067, + "Q": 0.076, + "R": 0.592, + "S": 0.13, + "T": 0.114, + "V": -0.453, + "W": -1.411, + "Y": -0.867, + } + self.NP10 = { + "A": -0.479, + "C": -0.663, + "D": 0.09, + "E": -0.654, + "F": 1.271, + "G": -1.153, + "H": -0.479, + "I": 1.516, + "K": 0.195, + "L": 0.658, + "M": 0.221, + "N": -1.161, + "P": 1.183, + "Q": -1.24, + "R": -0.496, + "S": -1.179, + "T": -1.179, + "V": 0.396, + "W": 2.058, + "Y": 1.096, + } + self.NP11 = { + "A": 0.253, + "C": -0.338, + "D": -0.836, + "E": -0.061, + "F": -0.836, + "G": 0.548, + "H": -0.522, + "I": -0.541, + "K": 0.548, + "L": -0.947, + "M": -0.928, + "N": 0.345, + "P": 3.703, + "Q": -0.227, + "R": 0.031, + "S": 0.474, + "T": 0.696, + "V": -0.725, + "W": -0.614, + "Y": -0.024, + } + self.NP12 = { + "A": -0.223, + "C": 1.256, + "D": -0.163, + "E": -0.042, + "F": -0.797, + "G": 1.588, + "H": -0.254, + "I": -1.008, + "K": -0.495, + "L": -1.189, + "M": -1.219, + "N": 1.98, + "P": 2.04, + "Q": -0.133, + "R": 0.048, + "S": 0.743, + "T": 0.169, + "V": -1.159, + "W": -0.948, + "Y": -0.193, + } + self.NP13 = { + "A": -0.277, + "C": -1.356, + "D": 0.311, + "E": -1.037, + "F": 0.532, + "G": -1.037, + "H": -0.253, + "I": 1.905, + "K": -0.816, + "L": 0.655, + "M": 0.385, + "N": -1.062, + "P": -1.552, + "Q": -0.203, + "R": -0.253, + "S": -0.522, + "T": 0.213, + "V": 1.905, + "W": 1.243, + "Y": 1.219, + } + self.NP14 = { + "A": -0.187, + "C": -0.393, + "D": 0.397, + "E": -2.352, + "F": 1.221, + "G": -0.393, + "H": -0.496, + "I": 1.805, + "K": -0.703, + "L": 0.843, + "M": 0.947, + "N": -1.012, + "P": -0.909, + "Q": 0.569, + "R": -1.184, + "S": -0.84, + "T": 0.74, + "V": 1.359, + "W": 0.397, + "Y": 0.191, + } + self.NP15 = { + "A": -0.402, + "C": -1.503, + "D": 0.469, + "E": -1.119, + "F": 0.443, + "G": -1.273, + "H": 0.161, + "I": 1.237, + "K": -0.812, + "L": 0.52, + "M": 0.085, + "N": -1.119, + "P": -1.631, + "Q": 0.315, + "R": -0.095, + "S": -0.479, + "T": 0.622, + "V": 1.211, + "W": 1.775, + "Y": 1.595, + } + self.NP16 = { + "A": -0.078, + "C": -0.667, + "D": -2.081, + "E": -0.562, + "F": -0.401, + "G": -0.097, + "H": 0.907, + "I": -0.066, + "K": 2.24, + "L": -0.091, + "M": -0.24, + "N": -0.444, + "P": 0.108, + "Q": -0.295, + "R": 2.872, + "S": -0.277, + "T": -0.289, + "V": -0.103, + "W": -0.147, + "Y": -0.289, + } + self.NP17 = { + "A": 1.728, + "C": -0.604, + "D": -0.7, + "E": -1.671, + "F": -1.152, + "G": 1.25, + "H": -0.292, + "I": -0.273, + "K": -0.47, + "L": -0.273, + "M": -0.082, + "N": 0.008, + "P": 2.445, + "Q": -0.534, + "R": 1.371, + "S": 0.333, + "T": -0.097, + "V": 0.097, + "W": 0.218, + "Y": -1.302, + } + self.NP18 = { + "A": -0.025, + "C": -1.322, + "D": -1.322, + "E": -1.249, + "F": 1.601, + "G": -0.81, + "H": -0.335, + "I": 1.291, + "K": -1.194, + "L": 1.382, + "M": 0.852, + "N": -0.847, + "P": 0.871, + "Q": -0.189, + "R": -0.993, + "S": -0.573, + "T": -0.098, + "V": 0.779, + "W": 1.273, + "Y": 0.907, + } + self.NP19 = { + "A": 0.549, + "C": -1.863, + "D": 0.137, + "E": 0.173, + "F": -2.131, + "G": 0.111, + "H": 0.152, + "I": 0.131, + "K": 0.853, + "L": 0.147, + "M": -0.946, + "N": 1.167, + "P": 0.229, + "Q": 1.059, + "R": 2.172, + "S": 0.147, + "T": 0.126, + "V": 0.085, + "W": -1.116, + "Y": -1.183, + } + self.NP20 = { + "A": -0.099, + "C": 1.717, + "D": -0.227, + "E": -0.277, + "F": 2.339, + "G": -0.385, + "H": 0.009, + "I": -0.223, + "K": -0.857, + "L": -0.231, + "M": 0.82, + "N": -1.081, + "P": -0.289, + "Q": -0.976, + "R": -1.996, + "S": -0.358, + "T": -0.281, + "V": -0.18, + "W": 1.431, + "Y": 1.145, + } + self.NP21 = { + "A": -0.2, + "C": 1.276, + "D": -0.28, + "E": -0.348, + "F": 2.725, + "G": -0.052, + "H": 0.578, + "I": -0.28, + "K": -0.602, + "L": -0.28, + "M": 0.538, + "N": -0.576, + "P": -0.254, + "Q": -0.482, + "R": -1.126, + "S": -0.71, + "T": -0.495, + "V": -0.254, + "W": 2.215, + "Y": -1.394, + } + + # Define 7 selected groups of 3 properties each + self.prop_groups = [ + (self.NP1, self.NP2, self.NP3), + (self.NP4, self.NP5, self.NP6), + (self.NP7, self.NP8, self.NP9), + (self.NP10, self.NP11, self.NP12), + (self.NP13, self.NP14, self.NP15), + (self.NP16, self.NP17, self.NP18), + (self.NP19, self.NP20, self.NP21), + ] + + def _check_validity(self, seq): + """ + Check if the sequence contains only valid amino acids. + + Parameters + ---------- + seq : str + Protein sequence. + + Raises + ------ + ValueError + If an invalid amino acid is found. + """ + for aa in seq: + if aa not in self.amino_acid: + raise ValueError( + f"Invalid amino acid '{aa}' found in protein_sequence. Only {self.amino_acid} are allowed." + ) + + # Function to average the amino acid composition + def _average_aa(self, seq): + """ + Compute the average amino acid composition for a sequence. + + Parameters + ---------- + seq : str + Protein sequence. + + Returns + ------- + dict + Dictionary mapping amino acid to its average frequency. + """ + count = {aa: 0 for aa in self.amino_acid} + for aa in seq: + if aa in count: + count[aa] += 1 + total = len(self.amino_acid) + + return {aa: count[aa] / total if total > 0 else 0 for aa in count} + + def _theta_RiRj(self, Ri, Rj, prop_group): + """ + Compute the theta value between two amino acids for a group of properties. + + Parameters + ---------- + Ri : str + First amino acid. + Rj : str + Second amino acid. + prop_group : tuple of dict + Tuple of property dictionaries. + + Returns + ------- + float + Theta value. + """ + return sum((prop[Rj] - prop[Ri]) ** 2 for prop in prop_group) / len(prop_group) + + def _sum_theta_val(self, seq, seq_len, lambda_val, n, prop_group): + """ + Compute the average theta value for a sequence and property group. + + Parameters + ---------- + seq : str + Protein sequence. + seq_len : int + Length of the sequence. + lambda_val : int + Lambda parameter. + n : int + Offset for theta calculation. + prop_group : tuple of dict + Tuple of property dictionaries. + + Returns + ------- + float + Average theta value. + """ + return sum( + self._theta_RiRj(seq[i], seq[i + n], prop_group) + for i in range(seq_len - lambda_val) + ) / (seq_len - n) + + def vectorize(self): + """ + Generate the PseAAC feature vector for the protein sequence. + + Returns + ------- + list of float + PseAAC feature vector. + """ + self._check_validity(self.protein_sequence) + + lambda_val = 30 + weight = 0.15 + all_pseaac = [] + + if len(self.protein_sequence) <= lambda_val: + raise ValueError( + f"Sequence too short for Lambda={lambda_val}. Must be > {lambda_val}." + ) + + for prop_group in self.prop_groups: + aa_freq = self._average_aa(self.protein_sequence) + sum_all_aa_freq = sum(aa_freq.values()) + + all_theta_val = [] + sum_all_theta_val = 0 + for n in range(1, lambda_val + 1): + theta_val = self._sum_theta_val( + self.protein_sequence, + len(self.protein_sequence), + lambda_val, + n, + prop_group, + ) + all_theta_val.append(theta_val) + sum_all_theta_val += theta_val + + denominator_val = sum_all_aa_freq + (weight * sum_all_theta_val) + print(f"Denominator value: {denominator_val}") + # First 20 features: normalized amino acid composition + for aa in self.amino_acid: + all_pseaac.append(round((aa_freq[aa] / denominator_val), 3)) + + # Next 30 features: theta values + for theta_val in all_theta_val: + all_pseaac.append(round((weight * theta_val / denominator_val), 3)) + + return all_pseaac diff --git a/pyaptamer/AptaNet/test_pseaac.py b/pyaptamer/AptaNet/test_pseaac.py new file mode 100644 index 00000000..457d24fc --- /dev/null +++ b/pyaptamer/AptaNet/test_pseaac.py @@ -0,0 +1,429 @@ +import numpy as np +import pytest +from pseaac import PSeAAC + + +def _normalize_properties(property_dicts): + """ + Takes multiple amino acid property dictionaries and returns their normalized versions. + Normalization: (value - mean) / std deviation + Returns a list of normalized dictionaries in the same order. + """ + normalized = [] + for prop in property_dicts: + values = list(prop.values()) + mean_val = sum(values) / len(values) + std_val = (sum((v - mean_val) ** 2 for v in values) / len(values)) ** 0.5 + normalized.append( + {aa: round((val - mean_val) / std_val, 3) for aa, val in prop.items()} + ) + return normalized + + +def test_normalized_values(): + """ + Test that normalized property dictionaries match expected NP values. + + Asserts + ------- + All normalized property values match the corresponding NP values for each amino acid. + """ + apt = PSeAAC("ACDEFGHIKLMNPQRSTVWY") + P_props = [getattr(apt, f"P{i}") for i in range(1, 21)] + normalized = _normalize_properties(P_props) + for i in range(1, 21): + np_dict = getattr(apt, f"NP{i}") + norm_dict = normalized[i - 1] + for aa in np_dict: + assert np_dict[aa] == norm_dict[aa], ( + f"Mismatch in NP{i} for {aa}: {np_dict[aa]} != {norm_dict[aa]}" + ) + + +@pytest.mark.parametrize( + "seq,expected_vector", + [ + ( + "ACDFFKKIIKKLLMMNNPPQQQRRRRIIIIRRR", + [ + 0.012, + 0.012, + 0.012, + 0.0, + 0.025, + 0.0, + 0.0, + 0.074, + 0.05, + 0.025, + 0.025, + 0.025, + 0.025, + 0.037, + 0.087, + 0.0, + 0.0, + 0.0, + 0.0, + 0.0, + 0.008, + 0.01, + 0.005, + 0.007, + 0.014, + 0.012, + 0.002, + 0.006, + 0.016, + 0.013, + 0.007, + 0.007, + 0.005, + 0.005, + 0.007, + 0.006, + 0.003, + 0.005, + 0.01, + 0.013, + 0.028, + 0.048, + 0.053, + 0.069, + 0.055, + 0.029, + 0.034, + 0.023, + 0.074, + 0.177, + 0.016, + 0.016, + 0.016, + 0.0, + 0.031, + 0.0, + 0.0, + 0.094, + 0.063, + 0.031, + 0.031, + 0.031, + 0.031, + 0.047, + 0.11, + 0.0, + 0.0, + 0.0, + 0.0, + 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0.06, + 0.051, + 0.031, + 0.007, + 0.006, + 0.006, + 0.005, + 0.006, + 0.01, + 0.031, + 0.05, + 0.058, + 0.063, + 0.039, + 0.019, + 0.015, + 0.015, + 0.015, + 0.0, + 0.031, + 0.0, + 0.0, + 0.092, + 0.061, + 0.031, + 0.031, + 0.031, + 0.031, + 0.046, + 0.107, + 0.0, + 0.0, + 0.0, + 0.0, + 0.0, + 0.005, + 0.006, + 0.009, + 0.004, + 0.004, + 0.016, + 0.023, + 0.01, + 0.001, + 0.007, + 0.009, + 0.008, + 0.012, + 0.007, + 0.01, + 0.011, + 0.004, + 0.01, + 0.008, + 0.012, + 0.01, + 0.011, + 0.012, + 0.017, + 0.056, + 0.086, + 0.101, + 0.115, + 0.07, + 0.041, + 0.009, + 0.009, + 0.009, + 0.0, + 0.018, + 0.0, + 0.0, + 0.053, + 0.035, + 0.018, + 0.018, + 0.018, + 0.018, + 0.027, + 0.062, + 0.0, + 0.0, + 0.0, + 0.0, + 0.0, + 0.006, + 0.009, + 0.011, + 0.012, + 0.01, + 0.01, + 0.011, + 0.012, + 0.012, + 0.012, + 0.009, + 0.008, + 0.006, + 0.004, + 0.012, + 0.02, + 0.011, + 0.004, + 0.007, + 0.024, + 0.037, + 0.044, + 0.049, + 0.037, + 0.031, + 0.03, + 0.036, + 0.074, + 0.113, + 0.163, + 0.011, + 0.011, + 0.011, + 0.0, + 0.021, + 0.0, + 0.0, + 0.064, + 0.043, + 0.021, + 0.021, + 0.021, + 0.021, + 0.032, + 0.075, + 0.0, + 0.0, + 0.0, + 0.0, + 0.0, + 0.014, + 0.008, + 0.009, + 0.015, + 0.007, + 0.004, + 0.005, + 0.008, + 0.008, + 0.005, + 0.007, + 0.003, + 0.004, + 0.015, + 0.013, + 0.008, + 0.008, + 0.015, + 0.016, + 0.023, + 0.04, + 0.05, + 0.054, + 0.051, + 0.023, + 0.016, + 0.018, + 0.039, + 0.118, + 0.182, + ], + ) + ], +) +def test_pseaac_vectorization(seq, expected_vector): + """ + Test that the PSeAAC vectorization produces the expected feature vector. + + Parameters + ---------- + seq : str + Protein sequence to vectorize. + expected_vector : list of float + Expected PSeAAC feature vector. + + Asserts + ------- + The produced vector matches the expected vector in length and values (within tolerance). + """ + p = PSeAAC(seq) + pv = p.vectorize() + + assert len(pv) == len(expected_vector), ( + f"Vector length mismatch: {len(pv)} != {len(expected_vector)}" + ) + mismatches = [ + (i, a, b) + for i, (a, b) in enumerate(zip(pv, expected_vector)) + if not np.isclose(a, b, atol=1e-3) + ] + assert not mismatches, f"Vector values mismatch at indices: {mismatches}" From 20d7e37e7a622d582ad06b0d36b8018f389ccf89 Mon Sep 17 00:00:00 2001 From: satvshr Date: Wed, 9 Jul 2025 01:37:44 +0530 Subject: [PATCH 008/145] Added docstrings, made functions pvt and made code more clean --- pyaptamer/AptaNet/aptanet.py | 109 ++++++++++++++++++ pyaptamer/AptaNet/neural_net.py | 198 ++++++++++++++++++++++++++++++++ 2 files changed, 307 insertions(+) create mode 100644 pyaptamer/AptaNet/aptanet.py create mode 100644 pyaptamer/AptaNet/neural_net.py diff --git a/pyaptamer/AptaNet/aptanet.py b/pyaptamer/AptaNet/aptanet.py new file mode 100644 index 00000000..cb59d346 --- /dev/null +++ b/pyaptamer/AptaNet/aptanet.py @@ -0,0 +1,109 @@ +from AptaNet.pseaac import pseaac + + +class AptaNet: + """ + AptaNet feature generator for aptamer-protein pairs. + + This class generates a combined feature vector using k-mer frequencies from the aptamer DNA sequence + and PseAAC features from the protein sequence. + + Parameters + ---------- + aptamer_sequence : str + The DNA sequence of the aptamer. + protein_sequence : str + The protein sequence to be analyzed. + + Attributes + ---------- + aptamer_sequence : str + The DNA sequence of the aptamer. + protein_sequence : str + The protein sequence to be analyzed. + amino_acid : list of str + List of 20 native amino acids in alphabetical order. + pseaac : pseaac + PseAAC object for the protein sequence. + """ + + def __init__(self, aptamer_sequence, protein_sequence): + """ + Initialize the AptaNet class with an aptamer sequence and a protein sequence. + + Parameters + ---------- + aptamer_sequence : str + The DNA sequence of the aptamer. + protein_sequence : str + The protein sequence to be analyzed. + """ + self.aptamer_sequence = aptamer_sequence + self.protein_sequence = protein_sequence + + # Define the 20 native amino acids according to the alphabetical order of their single-letter codes + self.amino_acid = list("ACDEFGHIKLMNPQRSTVWY") + + # Initialize the PseAAC object with the protein sequence + self.pseaac = pseaac(self, self.protein_sequence) + + def _generate_kmer_vecs(self, aptamer_sequence, k=4): + """ + Generate normalized k-mer frequency vectors for the aptamer sequence. + + For all possible k-mers from length 1 to k, count their occurrences in the sequence + and normalize to form a frequency vector. + + Parameters + ---------- + aptamer_sequence : str + The DNA sequence of the aptamer. + k : int, optional + Maximum k-mer length (default is 4). + + Returns + ------- + list of float + Normalized frequency vector for all possible k-mers from length 1 to k. + """ + from itertools import product + + bases = ["A", "C", "G", "T"] + + # Generate all possible k-mers from 1 to k + all_kmers = [] + for i in range(1, k + 1): + all_kmers.extend(["".join(p) for p in product(bases, repeat=i)]) + + # Count occurrences of each k-mer in the aptamer_sequence + kmer_counts = {kmer: 0 for kmer in all_kmers} + for i in range(len(aptamer_sequence)): + for j in range(1, k + 1): + if i + j <= len(aptamer_sequence): + kmer = aptamer_sequence[i : i + j] + if kmer in kmer_counts: + kmer_counts[kmer] += 1 + + # Normalize counts to frequencies + total_kmers = sum(kmer_counts.values()) + kmer_freq = [ + kmer_counts[kmer] / total_kmers if total_kmers > 0 else 0 + for kmer in all_kmers + ] + + return kmer_freq + + def generate_final_vector(self): + """ + Generate the final feature vector by concatenating k-mer and PseAAC features. + + Returns + ------- + list of float + Combined feature vector for the aptamer-protein pair. + """ + final_vector = ( + self._generate_kmer_vecs(self.aptamer_sequence, k=4) + self.pseaac + ) + + return final_vector diff --git a/pyaptamer/AptaNet/neural_net.py b/pyaptamer/AptaNet/neural_net.py new file mode 100644 index 00000000..f43437a3 --- /dev/null +++ b/pyaptamer/AptaNet/neural_net.py @@ -0,0 +1,198 @@ +import torch +import torch.nn as nn +import torch.optim as optim +import torch.nn.functional as F +from sklearn.ensemble import RandomForestClassifier +from sklearn.feature_selection import SelectFromModel + + +class MLP(nn.Module): + """ + Multi-layer Perceptron (MLP) for binary classification with feature selection. + + This model uses a RandomForest-based feature selector and a deep neural network + with AlphaDropout for robust training. + + Parameters + ---------- + input_dim : int, optional + Number of input features before feature selection (default is 639). + + Attributes + ---------- + clf : RandomForestClassifier + Random forest used for feature selection. + clf_model : SelectFromModel or None + Feature selector model after fitting. + criterion : nn.BCELoss + Binary cross-entropy loss function. + optimizer : torch.optim.Optimizer or None + Optimizer for training. + """ + + def __init__(self, input_dim=639): + """ + Initialize the MLP model. + + Parameters + ---------- + input_dim : int, optional + Number of input features before feature selection (default is 639). + """ + super(MLP, self).__init__() + + self.input_dim = input_dim + + self.fc1 = nn.Linear(input_dim, 128) + self.dropout1 = nn.AlphaDropout(0.3) + self.fc2 = nn.Linear(128, 128) + self.dropout2 = nn.AlphaDropout(0.3) + self.fc3 = nn.Linear(128, 128) + self.dropout3 = nn.AlphaDropout(0.3) + self.fc4 = nn.Linear(128, 128) + self.dropout4 = nn.AlphaDropout(0.3) + self.fc5 = nn.Linear(128, 128) + self.dropout5 = nn.AlphaDropout(0.3) + self.fc6 = nn.Linear(128, 128) + self.dropout6 = nn.AlphaDropout(0.3) + self.fc7 = nn.Linear(128, 1) # Binary classification + + self.criterion = nn.BCELoss() + self.optimizer = None + + # Random forest feature selector + self.clf = RandomForestClassifier(n_estimators=300, max_depth=9, random_state=0) + self.clf_model = None + + def _forward(self, x): + """ + Forward pass through the network. + + Parameters + ---------- + x : torch.Tensor + Input tensor of shape (batch_size, n_features). + + Returns + ------- + torch.Tensor + Output tensor with predicted probabilities. + """ + x = F.relu(self.fc1(x)) + x = self.dropout1(x) + x = F.relu(self.fc2(x)) + x = self.dropout2(x) + x = F.relu(self.fc3(x)) + x = self.dropout3(x) + x = F.relu(self.fc4(x)) + x = self.dropout4(x) + x = F.relu(self.fc5(x)) + x = self.dropout5(x) + x = F.relu(self.fc6(x)) + x = self.dropout6(x) + x = torch.sigmoid(self.fc7(x)) + return x + + def _train_clf_model(self, X, y): + """ + Train the random forest feature selector. + + Parameters + ---------- + X : array-like of shape (n_samples, n_features) + Training input samples. + y : array-like of shape (n_samples,) + Target values. + + Returns + ------- + SelectFromModel + Trained feature selector. + """ + self.clf.fit(X, y) + self.clf_model = SelectFromModel(self.clf, prefit=True) + return self.clf_model + + def _transform_X(self, X): + """ + Transform input features using the trained feature selector. + + Parameters + ---------- + X : array-like of shape (n_samples, n_features) + Input samples. + + Returns + ------- + array-like + Transformed input samples with selected features. + + Raises + ------ + ValueError + If the feature selector has not been trained. + """ + if self.clf_model is None: + raise ValueError("Classifier model has not been trained yet.") + return self.clf_model.transform(X) + + def fit(self, X, y, epochs=200, batch_size=310): + """ + Fit the MLP model to the training data. + + Parameters + ---------- + X : array-like of shape (n_samples, n_features) + Training input samples. + y : array-like of shape (n_samples,) + Target values. + epochs : int, optional + Number of training epochs (default is 200). + batch_size : int, optional + Batch size for training (default is 310). + """ + # Convert to PyTorch tensors + self.clf_model = self._train_clf_model(X, y) + X_transformed = self._transform_X(X) + X_tensor = torch.tensor(X_transformed, dtype=torch.float32) + y_tensor = torch.tensor(y, dtype=torch.float32).unsqueeze(1) + + self.optimizer = optim.RMSprop( + self.parameters(), lr=0.00014, alpha=0.9, eps=1e-07 + ) + + dataset = torch.utils.data.TensorDataset(X_tensor, y_tensor) + dataloader = torch.utils.data.DataLoader( + dataset, batch_size=batch_size, shuffle=True + ) + + self.train() + for epoch in range(epochs): + for batch_x, batch_y in dataloader: + self.optimizer.zero_grad() + output = self._forward(batch_x) + loss = self.criterion(output, batch_y) + loss.backward() + self.optimizer.step() + + def predict(self, X): + """ + Predict binary class labels for input samples. + + Parameters + ---------- + X : array-like of shape (n_samples, n_features) + Input samples. + + Returns + ------- + numpy.ndarray + Predicted class labels (0 or 1). + """ + self.eval() + X_transformed = self.transform_X(X) + X_tensor = torch.tensor(X_transformed, dtype=torch.float32) + with torch.no_grad(): + output = self._forward(X_tensor) + predictions = (output > 0.5).int().squeeze().numpy() + return predictions From fc2f051dd98c0473e0bfb1926484494532baffa3 Mon Sep 17 00:00:00 2001 From: satvshr Date: Wed, 9 Jul 2025 12:47:49 +0530 Subject: [PATCH 009/145] Removed AptaNet from root --- AptaNet/pseaac.py | 604 ----------------------------------------- AptaNet/test_pseaac.py | 398 --------------------------- 2 files changed, 1002 deletions(-) delete mode 100644 AptaNet/pseaac.py delete mode 100644 AptaNet/test_pseaac.py diff --git a/AptaNet/pseaac.py b/AptaNet/pseaac.py deleted file mode 100644 index fcb9fb7d..00000000 --- a/AptaNet/pseaac.py +++ /dev/null @@ -1,604 +0,0 @@ -class PSeAAC: - def __init__(self, protein_sequence): - self.protein_sequence = protein_sequence - self.amino_acid = list("ACDEFGHIKLMNPQRSTVWY") - - # The hydrophobicity values are from JACS, 1962, 84: 4240-4246. (C. Tanford). - self.P1 = { - "A": 0.62, - "C": 0.29, - "D": -0.90, - "E": -0.74, - "F": 1.19, - "G": 0.48, - "H": -0.40, - "I": 1.38, - "K": -1.50, - "L": 1.06, - "M": 0.64, - "N": -0.78, - "P": 0.12, - "Q": -0.85, - "R": -2.53, - "S": -0.18, - "T": -0.05, - "V": 1.08, - "W": 0.81, - "Y": 0.26, - } - - # The hydrophilicity values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods). - self.P2 = { - "A": -0.5, - "C": -1.0, - "D": 3.0, - "E": 3.0, - "F": -2.5, - "G": 0.0, - "H": -0.5, - "I": -1.8, - "K": 3.0, - "L": -1.8, - "M": -1.3, - "N": 0.2, - "P": 0.0, - "Q": 0.2, - "R": 3.0, - "S": 0.3, - "T": -0.4, - "V": -1.5, - "W": -3.4, - "Y": -2.3, - } - - # The side-chain mass for each of the 20 amino acids. - self.P3 = { - "A": 15.0, - "C": 47.0, - "D": 59.0, - "E": 73.0, - "F": 91.0, - "G": 1.0, - "H": 82.0, - "I": 57.0, - "K": 73.0, - "L": 57.0, - "M": 75.0, - "N": 58.0, - "P": 42.0, - "Q": 72.0, - "R": 101.0, - "S": 31.0, - "T": 45.0, - "V": 43.0, - "W": 130.0, - "Y": 107.0, - } - - # The Polarity values are from JACS, 1962, 84: 4240-4246. (C. Tanford). - self.P4 = { - "A": 0.5, - "C": 2.5, - "D": -1, - "E": 2.5, - "F": -2.5, - "G": 0, - "H": -0.5, - "I": 1.8, - "K": 3, - "L": -1.8, - "M": -1.3, - "N": 0.2, - "P": -1.4, - "Q": 0.2, - "R": 3, - "S": 0.3, - "T": -0.4, - "V": -1.5, - "W": -3.4, - "Y": -2.3, - } - - # The Molecular weight values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods). - self.P5 = { - "A": 5.3, - "C": 3.6, - "D": 1.3, - "E": 3.3, - "F": 2.3, - "G": 4.8, - "H": 1.4, - "I": 3.1, - "K": 4.1, - "L": 4.7, - "M": 1.1, - "N": 3, - "P": 2.5, - "Q": 2.4, - "R": 2.6, - "S": 4.5, - "T": 3.7, - "V": 4.2, - "W": 0.8, - "Y": 2.3, - } - - # The Meling point for each of the 20 amino acids. - self.P6 = { - "A": 0.81, - "C": 0.71, - "D": 1.17, - "E": 0.53, - "F": 1.2, - "G": 0.88, - "H": 0.92, - "I": 1.48, - "K": 0.77, - "L": 1.24, - "M": 1.05, - "N": 0.62, - "P": 0.61, - "Q": 0.98, - "R": 0.85, - "S": 0.92, - "T": 1.18, - "V": 1.66, - "W": 1.18, - "Y": 1.23, - } - - # The Transfer_free_energy values are from JACS, 1962, 84: 4240-4246. (C. Tanford). - self.P7 = { - "A": 58, - "C": -97, - "D": 116, - "E": -131, - "F": 92, - "G": -11, - "H": -73, - "I": 107, - "K": -24, - "L": 95, - "M": 78, - "N": -93, - "P": -79, - "Q": -139, - "R": -184, - "S": -34, - "T": -7, - "V": 100, - "W": 59, - "Y": -11, - } - - # The Buriability values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods). - self.P8 = { - "A": 1.37, - "C": 8.93, - "D": -4.47, - "E": 4.04, - "F": -7.96, - "G": 3.39, - "H": -1.65, - "I": -7.92, - "K": 7.7, - "L": -8.68, - "M": -7.13, - "N": 6.29, - "P": 6.25, - "Q": 3.88, - "R": 1.33, - "S": 4.08, - "T": 4.02, - "V": -6.94, - "W": 0.79, - "Y": -4.73, - } - - # The Bulkiness for each of the 20 amino acids. - self.P9 = { - "A": 6.77, - "C": 8.57, - "D": 0.31, - "E": 12.93, - "F": 1.92, - "G": 7.95, - "H": 2.8, - "I": 2.72, - "K": 10.2, - "L": 4.43, - "M": 1.87, - "N": 5.5, - "P": 4.79, - "Q": 5.24, - "R": 6.87, - "S": 5.41, - "T": 5.36, - "V": 3.57, - "W": 0.54, - "Y": 2.26, - } - - # The Solvation_free_energy values are from JACS, 1962, 84: 4240-4246. (C. Tanford). - self.P10 = { - "A": 0.87, - "C": 0.66, - "D": 1.52, - "E": 0.67, - "F": 2.87, - "G": 0.1, - "H": 0.87, - "I": 3.15, - "K": 1.64, - "L": 2.17, - "M": 1.67, - "N": 0.09, - "P": 2.77, - "Q": 0, - "R": 0.85, - "S": 0.07, - "T": 0.07, - "V": 1.87, - "W": 3.77, - "Y": 2.67, - } - - # The Relative_mutability values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods). - self.P11 = { - "A": 1.09, - "C": 0.77, - "D": 0.5, - "E": 0.92, - "F": 0.5, - "G": 1.25, - "H": 0.67, - "I": 0.66, - "K": 1.25, - "L": 0.44, - "M": 0.45, - "N": 1.14, - "P": 2.96, - "Q": 0.83, - "R": 0.97, - "S": 1.21, - "T": 1.33, - "V": 0.56, - "W": 0.62, - "Y": 0.94, - } - - # The Residue_volume for each of the 20 amino acids. - self.P12 = { - "A": 0.91, - "C": 1.4, - "D": 0.93, - "E": 0.97, - "F": 0.72, - "G": 1.51, - "H": 0.9, - "I": 0.65, - "K": 0.82, - "L": 0.59, - "M": 0.58, - "N": 1.64, - "P": 1.66, - "Q": 0.94, - "R": 1, - "S": 1.23, - "T": 1.04, - "V": 0.6, - "W": 0.67, - "Y": 0.92, - } - - # The volume values are from JACS, 1962, 84: 4240-4246. (C. Tanford). - self.P13 = { - "A": 0.92, - "C": 0.48, - "D": 1.16, - "E": 0.61, - "F": 1.25, - "G": 0.61, - "H": 0.93, - "I": 1.81, - "K": 0.7, - "L": 1.3, - "M": 1.19, - "N": 0.6, - "P": 0.4, - "Q": 0.95, - "R": 0.93, - "S": 0.82, - "T": 1.12, - "V": 1.81, - "W": 1.54, - "Y": 1.53, - } - - # The Amino_acid_distribution values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods). - self.P14 = { - "A": 0.96, - "C": 0.9, - "D": 1.13, - "E": 0.33, - "F": 1.37, - "G": 0.9, - "H": 0.87, - "I": 1.54, - "K": 0.81, - "L": 1.26, - "M": 1.29, - "N": 0.72, - "P": 0.75, - "Q": 1.18, - "R": 0.67, - "S": 0.77, - "T": 1.23, - "V": 1.41, - "W": 1.13, - "Y": 1.07, - } - - # The Hydration_number for each of the 20 amino acids. - self.P15 = { - "A": 0.9, - "C": 0.47, - "D": 1.24, - "E": 0.62, - "F": 1.23, - "G": 0.56, - "H": 1.12, - "I": 1.54, - "K": 0.74, - "L": 1.26, - "M": 1.09, - "N": 0.62, - "P": 0.42, - "Q": 1.18, - "R": 1.02, - "S": 0.87, - "T": 1.3, - "V": 1.53, - "W": 1.75, - "Y": 1.68, - } - - # The Isoelectric_point values are from JACS, 1962, 84: 4240-4246. (C. Tanford). - self.P16 = { - "A": 6, - "C": 5.05, - "D": 2.77, - "E": 5.22, - "F": 5.48, - "G": 5.97, - "H": 7.59, - "I": 6.02, - "K": 9.74, - "L": 5.98, - "M": 5.74, - "N": 5.41, - "P": 6.3, - "Q": 5.65, - "R": 10.76, - "S": 5.68, - "T": 5.66, - "V": 5.96, - "W": 5.89, - "Y": 5.66, - } - - # The Compressibility values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods). - self.P17 = { - "A": -25.5, - "C": -32.82, - "D": -33.12, - "E": -36.17, - "F": -34.54, - "G": -27, - "H": -31.84, - "I": -31.78, - "K": -32.4, - "L": -31.78, - "M": -31.18, - "N": -30.9, - "P": -23.25, - "Q": -32.6, - "R": -26.62, - "S": -29.88, - "T": -31.23, - "V": -30.62, - "W": -30.24, - "Y": -35.01, - } - - # The Chromatographic_index for each of the 20 amino acids. - self.P18 = { - "A": 9.9, - "C": 2.8, - "D": 2.8, - "E": 3.2, - "F": 18.8, - "G": 5.6, - "H": 8.2, - "I": 17.1, - "K": 3.5, - "L": 17.6, - "M": 14.7, - "N": 5.4, - "P": 14.8, - "Q": 9, - "R": 4.6, - "S": 6.9, - "T": 9.5, - "V": 14.3, - "W": 17, - "Y": 15, - } - - # The Unfolding_entropy_change values are from JACS, 1962, 84: 4240-4246. (C. Tanford). - self.P19 = { - "A": 0.54, - "C": -4.14, - "D": -0.26, - "E": -0.19, - "F": -4.66, - "G": -0.31, - "H": -0.23, - "I": -0.27, - "K": 1.13, - "L": -0.24, - "M": -2.36, - "N": 1.74, - "P": -0.08, - "Q": 1.53, - "R": 3.69, - "S": -0.24, - "T": -0.28, - "V": -0.36, - "W": -2.69, - "Y": -2.82, - } - - # The Unfolding_entalpy_change values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods). - self.P20 = { - "A": 0.51, - "C": 5.21, - "D": 0.18, - "E": 0.05, - "F": 6.82, - "G": -0.23, - "H": 0.79, - "I": 0.19, - "K": -1.45, - "L": 0.17, - "M": 2.89, - "N": -2.03, - "P": 0.02, - "Q": -1.76, - "R": -4.4, - "S": -0.16, - "T": 0.04, - "V": 0.3, - "W": 4.47, - "Y": 3.73, - } - - # The Unfolding_Gibbs_free_energy_change for each of the 20 amino acids. - self.P21 = { - "A": -0.02, - "C": 1.08, - "D": -0.08, - "E": -0.13, - "F": 2.16, - "G": 0.09, - "H": 0.56, - "I": -0.08, - "K": -0.32, - "L": -0.08, - "M": 0.53, - "N": -0.3, - "P": -0.06, - "Q": -0.23, - "R": -0.71, - "S": -0.4, - "T": -0.24, - "V": -0.06, - "W": 1.78, - "Y": -0.91, - } - - # Normalized properties upto 3 decimal places - self.NP1 = {'A': 0.636, 'C': 0.298, 'D': -0.924, 'E': -0.759, 'F': 1.221, 'G': 0.493, 'H': -0.41, 'I': 1.416, 'K': -1.539, 'L': 1.088, 'M': 0.657, 'N': -0.8, 'P': 0.123, 'Q': -0.872, 'R': -2.596, 'S': -0.185, 'T': -0.051, 'V': 1.108, 'W': 0.831, 'Y': 0.267} - self.NP2 = {'A': -0.152, 'C': -0.418, 'D': 1.713, 'E': 1.713, 'F': -1.218, 'G': 0.115, 'H': -0.152, 'I': -0.845, 'K': 1.713, 'L': -0.845, 'M': -0.578, 'N': 0.221, 'P': 0.115, 'Q': 0.221, 'R': 1.713, 'S': 0.274, 'T': -0.099, 'V': -0.685, 'W': -1.697, 'Y': -1.111} - self.NP3 = {'A': -1.592, 'C': -0.53, 'D': -0.131, 'E': 0.334, 'F': 0.931, 'G': -2.057, 'H': 0.632, 'I': -0.198, 'K': 0.334, 'L': -0.198, 'M': 0.4, 'N': -0.164, 'P': -0.696, 'Q': 0.3, 'R': 1.263, 'S': -1.061, 'T': -0.596, 'V': -0.662, 'W': 2.226, 'Y': 1.462} - self.NP4 = {'A': 0.329, 'C': 1.417, 'D': -0.487, 'E': 1.417, 'F': -1.303, 'G': 0.057, 'H': -0.215, 'I': 1.036, 'K': 1.689, 'L': -0.922, 'M': -0.65, 'N': 0.166, 'P': -0.704, 'Q': 0.166, 'R': 1.689, 'S': 0.22, 'T': -0.16, 'V': -0.759, 'W': -1.792, 'Y': -1.194} - self.NP5 = {'A': 1.755, 'C': 0.429, 'D': -1.365, 'E': 0.195, 'F': -0.585, 'G': 1.365, 'H': -1.287, 'I': 0.039, 'K': 0.819, 'L': 1.287, 'M': -1.521, 'N': -0.039, 'P': -0.429, 'Q': -0.507, 'R': -0.351, 'S': 1.131, 'T': 0.507, 'V': 0.897, 'W': -1.755, 'Y': -0.585} - self.NP6 = {'A': -0.659, 'C': -1.007, 'D': 0.593, 'E': -1.633, 'F': 0.697, 'G': -0.416, 'H': -0.277, 'I': 1.671, 'K': -0.798, 'L': 0.836, 'M': 0.176, 'N': -1.32, 'P': -1.355, 'Q': -0.068, 'R': -0.52, 'S': -0.277, 'T': 0.628, 'V': 2.297, 'W': 0.628, 'Y': 0.802} - self.NP7 = {'A': 0.735, 'C': -0.968, 'D': 1.372, 'E': -1.341, 'F': 1.108, 'G': -0.023, 'H': -0.704, 'I': 1.273, 'K': -0.166, 'L': 1.141, 'M': 0.955, 'N': -0.924, 'P': -0.77, 'Q': -1.429, 'R': -1.924, 'S': -0.276, 'T': 0.021, 'V': 1.196, 'W': 0.746, 'Y': -0.023} - self.NP8 = {'A': 0.219, 'C': 1.552, 'D': -0.811, 'E': 0.69, 'F': -1.427, 'G': 0.575, 'H': -0.314, 'I': -1.42, 'K': 1.335, 'L': -1.554, 'M': -1.281, 'N': 1.087, 'P': 1.08, 'Q': 0.662, 'R': 0.212, 'S': 0.697, 'T': 0.686, 'V': -1.247, 'W': 0.117, 'Y': -0.857} - self.NP9 = {'A': 0.56, 'C': 1.13, 'D': -1.484, 'E': 2.509, 'F': -0.975, 'G': 0.933, 'H': -0.696, 'I': -0.722, 'K': 1.645, 'L': -0.181, 'M': -0.991, 'N': 0.158, 'P': -0.067, 'Q': 0.076, 'R': 0.592, 'S': 0.13, 'T': 0.114, 'V': -0.453, 'W': -1.411, 'Y': -0.867} - self.NP10 = {'A': -0.479, 'C': -0.663, 'D': 0.09, 'E': -0.654, 'F': 1.271, 'G': -1.153, 'H': -0.479, 'I': 1.516, 'K': 0.195, 'L': 0.658, 'M': 0.221, 'N': -1.161, 'P': 1.183, 'Q': -1.24, 'R': -0.496, 'S': -1.179, 'T': -1.179, 'V': 0.396, 'W': 2.058, 'Y': 1.096} - self.NP11 = {'A': 0.253, 'C': -0.338, 'D': -0.836, 'E': -0.061, 'F': -0.836, 'G': 0.548, 'H': -0.522, 'I': -0.541, 'K': 0.548, 'L': -0.947, 'M': -0.928, 'N': 0.345, 'P': 3.703, 'Q': -0.227, 'R': 0.031, 'S': 0.474, 'T': 0.696, 'V': -0.725, 'W': -0.614, 'Y': -0.024} - self.NP12 = {'A': -0.223, 'C': 1.256, 'D': -0.163, 'E': -0.042, 'F': -0.797, 'G': 1.588, 'H': -0.254, 'I': -1.008, 'K': -0.495, 'L': -1.189, 'M': -1.219, 'N': 1.98, 'P': 2.04, 'Q': -0.133, 'R': 0.048, 'S': 0.743, 'T': 0.169, 'V': -1.159, 'W': -0.948, 'Y': -0.193} - self.NP13 = {'A': -0.277, 'C': -1.356, 'D': 0.311, 'E': -1.037, 'F': 0.532, 'G': -1.037, 'H': -0.253, 'I': 1.905, 'K': -0.816, 'L': 0.655, 'M': 0.385, 'N': -1.062, 'P': -1.552, 'Q': -0.203, 'R': -0.253, 'S': -0.522, 'T': 0.213, 'V': 1.905, 'W': 1.243, 'Y': 1.219} - self.NP14 = {'A': -0.187, 'C': -0.393, 'D': 0.397, 'E': -2.352, 'F': 1.221, 'G': -0.393, 'H': -0.496, 'I': 1.805, 'K': -0.703, 'L': 0.843, 'M': 0.947, 'N': -1.012, 'P': -0.909, 'Q': 0.569, 'R': -1.184, 'S': -0.84, 'T': 0.74, 'V': 1.359, 'W': 0.397, 'Y': 0.191} - self.NP15 = {'A': -0.402, 'C': -1.503, 'D': 0.469, 'E': -1.119, 'F': 0.443, 'G': -1.273, 'H': 0.161, 'I': 1.237, 'K': -0.812, 'L': 0.52, 'M': 0.085, 'N': -1.119, 'P': -1.631, 'Q': 0.315, 'R': -0.095, 'S': -0.479, 'T': 0.622, 'V': 1.211, 'W': 1.775, 'Y': 1.595} - self.NP16 = {'A': -0.078, 'C': -0.667, 'D': -2.081, 'E': -0.562, 'F': -0.401, 'G': -0.097, 'H': 0.907, 'I': -0.066, 'K': 2.24, 'L': -0.091, 'M': -0.24, 'N': -0.444, 'P': 0.108, 'Q': -0.295, 'R': 2.872, 'S': -0.277, 'T': -0.289, 'V': -0.103, 'W': -0.147, 'Y': -0.289} - self.NP17 = {'A': 1.728, 'C': -0.604, 'D': -0.7, 'E': -1.671, 'F': -1.152, 'G': 1.25, 'H': -0.292, 'I': -0.273, 'K': -0.47, 'L': -0.273, 'M': -0.082, 'N': 0.008, 'P': 2.445, 'Q': -0.534, 'R': 1.371, 'S': 0.333, 'T': -0.097, 'V': 0.097, 'W': 0.218, 'Y': -1.302} - self.NP18 = {'A': -0.025, 'C': -1.322, 'D': -1.322, 'E': -1.249, 'F': 1.601, 'G': -0.81, 'H': -0.335, 'I': 1.291, 'K': -1.194, 'L': 1.382, 'M': 0.852, 'N': -0.847, 'P': 0.871, 'Q': -0.189, 'R': -0.993, 'S': -0.573, 'T': -0.098, 'V': 0.779, 'W': 1.273, 'Y': 0.907} - self.NP19 = {'A': 0.549, 'C': -1.863, 'D': 0.137, 'E': 0.173, 'F': -2.131, 'G': 0.111, 'H': 0.152, 'I': 0.131, 'K': 0.853, 'L': 0.147, 'M': -0.946, 'N': 1.167, 'P': 0.229, 'Q': 1.059, 'R': 2.172, 'S': 0.147, 'T': 0.126, 'V': 0.085, 'W': -1.116, 'Y': -1.183} - self.NP20 = {'A': -0.099, 'C': 1.717, 'D': -0.227, 'E': -0.277, 'F': 2.339, 'G': -0.385, 'H': 0.009, 'I': -0.223, 'K': -0.857, 'L': -0.231, 'M': 0.82, 'N': -1.081, 'P': -0.289, 'Q': -0.976, 'R': -1.996, 'S': -0.358, 'T': -0.281, 'V': -0.18, 'W': 1.431, 'Y': 1.145} - self.NP21 = {'A': -0.2, 'C': 1.276, 'D': -0.28, 'E': -0.348, 'F': 2.725, 'G': -0.052, 'H': 0.578, 'I': -0.28, 'K': -0.602, 'L': -0.28, 'M': 0.538, 'N': -0.576, 'P': -0.254, 'Q': -0.482, 'R': -1.126, 'S': -0.71, 'T': -0.495, 'V': -0.254, 'W': 2.215, 'Y': -1.394} - - # Define 7 selected groups of 3 properties each - self.prop_groups = [ - (self.NP1, self.NP2, self.NP3), - (self.NP4, self.NP5, self.NP6), - (self.NP7, self.NP8, self.NP9), - (self.NP10, self.NP11, self.NP12), - (self.NP13, self.NP14, self.NP15), - (self.NP16, self.NP17, self.NP18), - (self.NP19, self.NP20, self.NP21), - ] - - def _check_validity(self, seq): - for aa in seq: - if aa not in self.amino_acid: - raise ValueError( - f"Invalid amino acid '{aa}' found in protein_sequence. Only {self.amino_acid} are allowed." - ) - - # Function to average the amino acid composition - def _average_aa(self, seq): - count = {aa: 0 for aa in self.amino_acid} - for aa in seq: - if aa in count: - count[aa] += 1 - total = len(self.amino_acid) - - return {aa: count[aa] / total if total > 0 else 0 for aa in count} - - def _theta_RiRj(self, Ri, Rj, prop_group): - return sum((prop[Rj] - prop[Ri]) ** 2 for prop in prop_group) / len(prop_group) - - def _sum_theta_val(self, seq, seq_len, lambda_val, n, prop_group): - return sum( - self._theta_RiRj(seq[i], seq[i + n], prop_group) for i in range(seq_len - lambda_val) - ) / (seq_len - n) - - def vectorize(self): - self._check_validity(self.protein_sequence) - - lambda_val = 30 - weight = 0.15 - all_pseaac = [] - - if len(self.protein_sequence) <= lambda_val: - raise ValueError( - f"Sequence too short for Lambda={lambda_val}. Must be > {lambda_val}." - ) - - for prop_group in self.prop_groups: - aa_freq = self._average_aa(self.protein_sequence) - sum_all_aa_freq = sum(aa_freq.values()) - - all_theta_val = [] - sum_all_theta_val = 0 - for n in range(1, lambda_val + 1): - theta_val = self._sum_theta_val( - self.protein_sequence, len(self.protein_sequence), lambda_val, n, prop_group - ) - all_theta_val.append(theta_val) - sum_all_theta_val += theta_val - - denominator_val = sum_all_aa_freq + (weight * sum_all_theta_val) - print(f"Denominator value: {denominator_val}") - # First 20 features: normalized amino acid composition - for aa in self.amino_acid: - all_pseaac.append(round((aa_freq[aa] / denominator_val), 3)) - - # Next 30 features: theta values - for theta_val in all_theta_val: - all_pseaac.append(round((weight * theta_val / denominator_val), 3)) - - return all_pseaac \ No newline at end of file diff --git a/AptaNet/test_pseaac.py b/AptaNet/test_pseaac.py deleted file mode 100644 index a1b645e0..00000000 --- a/AptaNet/test_pseaac.py +++ /dev/null @@ -1,398 +0,0 @@ -import numpy as np -import pytest -from pseaac import PSeAAC - -def _normalize_properties(property_dicts): - """ - Takes multiple amino acid property dictionaries and returns their normalized versions. - Normalization: (value - mean) / std deviation - Returns a list of normalized dictionaries in the same order. - """ - normalized = [] - for prop in property_dicts: - values = list(prop.values()) - mean_val = sum(values) / len(values) - std_val = (sum((v - mean_val) ** 2 for v in values) / len(values)) ** 0.5 - normalized.append( - {aa: round((val - mean_val) / std_val, 3) for aa, val in prop.items()} - ) - return normalized - -def test_normalized_values(): - apt = PSeAAC("ACDEFGHIKLMNPQRSTVWY") - P_props = [getattr(apt, f"P{i}") for i in range(1, 21)] - normalized = _normalize_properties(P_props) - for i in range(1, 21): - np_dict = getattr(apt, f"NP{i}") - norm_dict = normalized[i - 1] - for aa in np_dict: - assert np_dict[aa] == norm_dict[aa], f"Mismatch in NP{i} for {aa}: {np_dict[aa]} != {norm_dict[aa]}" - - -@pytest.mark.parametrize("seq,expected_vector", [ - ( - "ACDFFKKIIKKLLMMNNPPQQQRRRRIIIIRRR", - [ - 0.012, - 0.012, - 0.012, - 0.0, - 0.025, - 0.0, - 0.0, - 0.074, - 0.05, - 0.025, - 0.025, - 0.025, - 0.025, - 0.037, - 0.087, - 0.0, - 0.0, - 0.0, - 0.0, - 0.0, - 0.008, - 0.01, - 0.005, - 0.007, - 0.014, - 0.012, - 0.002, - 0.006, - 0.016, - 0.013, - 0.007, - 0.007, - 0.005, - 0.005, - 0.007, - 0.006, - 0.003, - 0.005, - 0.01, - 0.013, - 0.028, - 0.048, - 0.053, - 0.069, - 0.055, - 0.029, - 0.034, - 0.023, - 0.074, - 0.177, - 0.016, - 0.016, - 0.016, - 0.0, - 0.031, - 0.0, - 0.0, - 0.094, - 0.063, - 0.031, - 0.031, - 0.031, - 0.031, - 0.047, - 0.11, - 0.0, - 0.0, - 0.0, - 0.0, - 0.0, - 0.007, - 0.012, - 0.017, - 0.012, - 0.005, - 0.009, - 0.017, - 0.013, - 0.007, - 0.013, - 0.01, - 0.01, - 0.022, - 0.017, - 0.009, - 0.013, - 0.013, - 0.012, - 0.012, - 0.019, - 0.018, - 0.02, - 0.022, - 0.022, - 0.038, - 0.049, - 0.057, - 0.073, - 0.066, - 0.074, - 0.012, - 0.012, - 0.012, - 0.0, - 0.025, - 0.0, - 0.0, - 0.074, - 0.05, - 0.025, - 0.025, - 0.025, - 0.025, - 0.037, - 0.087, - 0.0, - 0.0, - 0.0, - 0.0, - 0.0, - 0.009, - 0.01, - 0.016, - 0.01, - 0.002, - 0.01, - 0.018, - 0.011, - 0.003, - 0.011, - 0.011, - 0.012, - 0.02, - 0.011, - 0.01, - 0.011, - 0.014, - 0.015, - 0.017, - 0.022, - 0.025, - 0.03, - 0.033, - 0.015, - 0.039, - 0.04, - 0.047, - 0.094, - 0.074, - 0.108, - 0.019, - 0.019, - 0.019, - 0.0, - 0.039, - 0.0, - 0.0, - 0.117, - 0.078, - 0.039, - 0.039, - 0.039, - 0.039, - 0.058, - 0.136, - 0.0, - 0.0, - 0.0, - 0.0, - 0.0, - 0.004, - 0.007, - 0.01, - 0.008, - 0.006, - 0.01, - 0.013, - 0.009, - 0.005, - 0.009, - 0.011, - 0.011, - 0.017, - 0.012, - 0.036, - 0.06, - 0.051, - 0.031, - 0.007, - 0.006, - 0.006, - 0.005, - 0.006, - 0.01, - 0.031, - 0.05, - 0.058, - 0.063, - 0.039, - 0.019, - 0.015, - 0.015, - 0.015, - 0.0, - 0.031, - 0.0, - 0.0, - 0.092, - 0.061, - 0.031, - 0.031, - 0.031, - 0.031, - 0.046, - 0.107, - 0.0, - 0.0, - 0.0, - 0.0, - 0.0, - 0.005, - 0.006, - 0.009, - 0.004, - 0.004, - 0.016, - 0.023, - 0.01, - 0.001, - 0.007, - 0.009, - 0.008, - 0.012, - 0.007, - 0.01, - 0.011, - 0.004, - 0.01, - 0.008, - 0.012, - 0.01, - 0.011, - 0.012, - 0.017, - 0.056, - 0.086, - 0.101, - 0.115, - 0.07, - 0.041, - 0.009, - 0.009, - 0.009, - 0.0, - 0.018, - 0.0, - 0.0, - 0.053, - 0.035, - 0.018, - 0.018, - 0.018, - 0.018, - 0.027, - 0.062, - 0.0, - 0.0, - 0.0, - 0.0, - 0.0, - 0.006, - 0.009, - 0.011, - 0.012, - 0.01, - 0.01, - 0.011, - 0.012, - 0.012, - 0.012, - 0.009, - 0.008, - 0.006, - 0.004, - 0.012, - 0.02, - 0.011, - 0.004, - 0.007, - 0.024, - 0.037, - 0.044, - 0.049, - 0.037, - 0.031, - 0.03, - 0.036, - 0.074, - 0.113, - 0.163, - 0.011, - 0.011, - 0.011, - 0.0, - 0.021, - 0.0, - 0.0, - 0.064, - 0.043, - 0.021, - 0.021, - 0.021, - 0.021, - 0.032, - 0.075, - 0.0, - 0.0, - 0.0, - 0.0, - 0.0, - 0.014, - 0.008, - 0.009, - 0.015, - 0.007, - 0.004, - 0.005, - 0.008, - 0.008, - 0.005, - 0.007, - 0.003, - 0.004, - 0.015, - 0.013, - 0.008, - 0.008, - 0.015, - 0.016, - 0.023, - 0.04, - 0.05, - 0.054, - 0.051, - 0.023, - 0.016, - 0.018, - 0.039, - 0.118, - 0.182, - ] - ) -]) -def test_pseaac_vectorization(seq, expected_vector): - p = PSeAAC(seq) - pv = p.vectorize() - - assert len(pv) == len(expected_vector), f"Vector length mismatch: {len(pv)} != {len(expected_vector)}" - mismatches = [ - (i, a, b) for i, (a, b) in enumerate(zip(pv, expected_vector)) - if not np.isclose(a, b, atol=1e-3) - ] - assert not mismatches, f"Vector values mismatch at indices: {mismatches}" \ No newline at end of file From 62f6c4250a0c20cb9046601bcdcf39f0f0ee9d44 Mon Sep 17 00:00:00 2001 From: satvshr Date: Wed, 9 Jul 2025 12:49:31 +0530 Subject: [PATCH 010/145] Added example --- pyaptamer/AptaNet/pseaac.py | 7 +++++++ 1 file changed, 7 insertions(+) diff --git a/pyaptamer/AptaNet/pseaac.py b/pyaptamer/AptaNet/pseaac.py index 90c10e4b..1bbb0955 100644 --- a/pyaptamer/AptaNet/pseaac.py +++ b/pyaptamer/AptaNet/pseaac.py @@ -6,6 +6,13 @@ class PSeAAC: ---------- protein_sequence : str Protein sequence using single-letter amino acid codes. + + Example + ------- + >>> pse = PSeAAC("ACDEFGHIKLMNPQRSTVWY") + >>> features = pse.vectorize() + >>> print(features[:10]) + [0.05, 0.05, 0.05, 0.05, 0.05, 0.05, 0.05, 0.05, 0.05, 0.05] """ def __init__(self, protein_sequence): From 848fc9b8a52d8831ff5b325478faadeda5bc12c4 Mon Sep 17 00:00:00 2001 From: satvshr Date: Wed, 9 Jul 2025 23:00:04 +0530 Subject: [PATCH 011/145] Removed AptaNet from root --- AptaNet/aptanet.py | 48 ----------------------- AptaNet/neural_net.py | 90 ------------------------------------------- 2 files changed, 138 deletions(-) delete mode 100644 AptaNet/aptanet.py delete mode 100644 AptaNet/neural_net.py diff --git a/AptaNet/aptanet.py b/AptaNet/aptanet.py deleted file mode 100644 index ccf9fe68..00000000 --- a/AptaNet/aptanet.py +++ /dev/null @@ -1,48 +0,0 @@ -from AptaNet.pseaac import pseaac - -class AptaNet: - def __init__(self, aptamer_sequence, protein_sequence): - """ - Initialize the AptaNetInput class with an aptamer sequence and a protein sequence. - :param aptamer_sequence: The DNA sequence of the aptamer. - :param protein_sequence: The protein sequence to be analyzed. - """ - self.aptamer_sequence = aptamer_sequence - self.protein_sequence = protein_sequence - - # Define the 20 native amino acids according to the alphabetical order of their single-letter codes - self.amino_acid = list("ACDEFGHIKLMNPQRSTVWY") - - # Initialize the PseAAC object with the protein sequence - self.pseaac = pseaac(self, self.protein_sequence) - - # Do what repDNA is doing in the original code, i.e. generating all possible DNA pairs till k-mer length for the aptamer, and then normalizing the frequency to form a vector - def generate_kmer_vecs(self, aptamer_sequence, k=4): - from itertools import product - - bases = ["A", "C", "G", "T"] - - # Generate all possible k-mers from 1 to k - all_kmers = [] - for i in range(1, k + 1): - all_kmers.extend(["".join(p) for p in product(bases, repeat=i)]) - - # Count occurrences of each k-mer in the aptamer_sequence - kmer_counts = {kmer: 0 for kmer in all_kmers} - for i in range(len(aptamer_sequence)): - for j in range(1, k + 1): - if i + j <= len(aptamer_sequence): - kmer = aptamer_sequence[i:i + j] - if kmer in kmer_counts: - kmer_counts[kmer] += 1 - - # Normalize counts to frequencies (like normalize_aa) - total_kmers = sum(kmer_counts.values()) - kmer_freq = [kmer_counts[kmer] / total_kmers if total_kmers > 0 else 0 for kmer in all_kmers] - - return kmer_freq - - def generate_final_vector(self): - final_vector = self.generate_kmer_vecs(self.aptamer_sequence, k=4) + self.pseaac - - return final_vector \ No newline at end of file diff --git a/AptaNet/neural_net.py b/AptaNet/neural_net.py deleted file mode 100644 index 6c67bedc..00000000 --- a/AptaNet/neural_net.py +++ /dev/null @@ -1,90 +0,0 @@ -import torch -import torch.nn as nn -import torch.optim as optim -import torch.nn.functional as F -from sklearn.ensemble import RandomForestClassifier -from sklearn.feature_selection import SelectFromModel - - -class MLP(nn.Module): - def __init__(self, input_dim=639): - super(MLP, self).__init__() - - self.input_dim = input_dim - - self.fc1 = nn.Linear(input_dim, 128) - self.dropout1 = nn.AlphaDropout(0.3) - self.fc2 = nn.Linear(128, 128) - self.dropout2 = nn.AlphaDropout(0.3) - self.fc3 = nn.Linear(128, 128) - self.dropout3 = nn.AlphaDropout(0.3) - self.fc4 = nn.Linear(128, 128) - self.dropout4 = nn.AlphaDropout(0.3) - self.fc5 = nn.Linear(128, 128) - self.dropout5 = nn.AlphaDropout(0.3) - self.fc6 = nn.Linear(128, 128) - self.dropout6 = nn.AlphaDropout(0.3) - self.fc7 = nn.Linear(128, 1) # Binary classification - - self.criterion = nn.BCELoss() - self.optimizer = None - - # Random forest feature selector - self.clf = RandomForestClassifier(n_estimators=300, max_depth=9, random_state=0) - self.clf_model = None - - def forward(self, x): - x = F.relu(self.fc1(x)) - x = self.dropout1(x) - x = F.relu(self.fc2(x)) - x = self.dropout2(x) - x = F.relu(self.fc3(x)) - x = self.dropout3(x) - x = F.relu(self.fc4(x)) - x = self.dropout4(x) - x = F.relu(self.fc5(x)) - x = self.dropout5(x) - x = F.relu(self.fc6(x)) - x = self.dropout6(x) - x = torch.sigmoid(self.fc7(x)) - return x - - def train_clf_model(self, X, y): - self.clf.fit(X, y) - self.clf_model = SelectFromModel(self.clf, prefit=True) - return self.clf_model - - def transform_X(self, X): - if self.clf_model is None: - raise ValueError("Classifier model has not been trained yet.") - return self.clf_model.transform(X) - - def fit_model(self, X, y, epochs=200, batch_size=310): - # Convert to PyTorch tensors - self.clf_model = self.train_clf_model(X, y) - X_transformed = self.transform_X(X) - X_tensor = torch.tensor(X_transformed, dtype=torch.float32) - y_tensor = torch.tensor(y, dtype=torch.float32).unsqueeze(1) - - self.optimizer = optim.RMSprop(self.parameters(), lr=0.00014, alpha=0.9, eps=1e-07) - - dataset = torch.utils.data.TensorDataset(X_tensor, y_tensor) - dataloader = torch.utils.data.DataLoader(dataset, batch_size=batch_size, shuffle=True) - - self.train() - for epoch in range(epochs): - for batch_x, batch_y in dataloader: - self.optimizer.zero_grad() - output = self.forward(batch_x) - loss = self.criterion(output, batch_y) - loss.backward() - self.optimizer.step() - - def predict(self, X): - self.eval() - X_transformed = self.transform_X(X) - X_tensor = torch.tensor(X_transformed, dtype=torch.float32) - with torch.no_grad(): - output = self.forward(X_tensor) - predictions = (output > 0.5).int().squeeze().numpy() - return predictions \ No newline at end of file From 1515efe2cce0a1be5cea9315b96b1a558282a9af Mon Sep 17 00:00:00 2001 From: satvshr Date: Wed, 9 Jul 2025 23:51:33 +0530 Subject: [PATCH 012/145] Made requested changes --- pyaptamer/AptaNet/_props.py | 967 ++++++++++++++++++++++++++ pyaptamer/AptaNet/pseaac.py | 1091 ++---------------------------- pyaptamer/AptaNet/test_pseaac.py | 4 +- pyaptamer/AptaNet/utils.py | 17 + 4 files changed, 1037 insertions(+), 1042 deletions(-) create mode 100644 pyaptamer/AptaNet/_props.py create mode 100644 pyaptamer/AptaNet/utils.py diff --git a/pyaptamer/AptaNet/_props.py b/pyaptamer/AptaNet/_props.py new file mode 100644 index 00000000..af3a5bfb --- /dev/null +++ b/pyaptamer/AptaNet/_props.py @@ -0,0 +1,967 @@ +# The hydrophobicity values are from JACS, 1962, 84: 4240-4246. (C. Tanford). +P1 = { + "A": 0.62, + "C": 0.29, + "D": -0.90, + "E": -0.74, + "F": 1.19, + "G": 0.48, + "H": -0.40, + "I": 1.38, + "K": -1.50, + "L": 1.06, + "M": 0.64, + "N": -0.78, + "P": 0.12, + "Q": -0.85, + "R": -2.53, + "S": -0.18, + "T": -0.05, + "V": 1.08, + "W": 0.81, + "Y": 0.26, +} + +# The hydrophilicity values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods). +P2 = { + "A": -0.5, + "C": -1.0, + "D": 3.0, + "E": 3.0, + "F": -2.5, + "G": 0.0, + "H": -0.5, + "I": -1.8, + "K": 3.0, + "L": -1.8, + "M": -1.3, + "N": 0.2, + "P": 0.0, + "Q": 0.2, + "R": 3.0, + "S": 0.3, + "T": -0.4, + "V": -1.5, + "W": -3.4, + "Y": -2.3, +} + +# The side-chain mass for each of the 20 amino acids. +P3 = { + "A": 15.0, + "C": 47.0, + "D": 59.0, + "E": 73.0, + "F": 91.0, + "G": 1.0, + "H": 82.0, + "I": 57.0, + "K": 73.0, + "L": 57.0, + "M": 75.0, + "N": 58.0, + "P": 42.0, + "Q": 72.0, + "R": 101.0, + "S": 31.0, + "T": 45.0, + "V": 43.0, + "W": 130.0, + "Y": 107.0, +} + +# The Polarity values are from JACS, 1962, 84: 4240-4246. (C. Tanford). +P4 = { + "A": 0.5, + "C": 2.5, + "D": -1, + "E": 2.5, + "F": -2.5, + "G": 0, + "H": -0.5, + "I": 1.8, + "K": 3, + "L": -1.8, + "M": -1.3, + "N": 0.2, + "P": -1.4, + "Q": 0.2, + "R": 3, + "S": 0.3, + "T": -0.4, + "V": -1.5, + "W": -3.4, + "Y": -2.3, +} + +# The Molecular weight values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods). +P5 = { + "A": 5.3, + "C": 3.6, + "D": 1.3, + "E": 3.3, + "F": 2.3, + "G": 4.8, + "H": 1.4, + "I": 3.1, + "K": 4.1, + "L": 4.7, + "M": 1.1, + "N": 3, + "P": 2.5, + "Q": 2.4, + "R": 2.6, + "S": 4.5, + "T": 3.7, + "V": 4.2, + "W": 0.8, + "Y": 2.3, +} + +# The Meling point for each of the 20 amino acids. +P6 = { + "A": 0.81, + "C": 0.71, + "D": 1.17, + "E": 0.53, + "F": 1.2, + "G": 0.88, + "H": 0.92, + "I": 1.48, + "K": 0.77, + "L": 1.24, + "M": 1.05, + "N": 0.62, + "P": 0.61, + "Q": 0.98, + "R": 0.85, + "S": 0.92, + "T": 1.18, + "V": 1.66, + "W": 1.18, + "Y": 1.23, +} + +# The Transfer_free_energy values are from JACS, 1962, 84: 4240-4246. (C. Tanford). +P7 = { + "A": 58, + "C": -97, + "D": 116, + "E": -131, + "F": 92, + "G": -11, + "H": -73, + "I": 107, + "K": -24, + "L": 95, + "M": 78, + "N": -93, + "P": -79, + "Q": -139, + "R": -184, + "S": -34, + "T": -7, + "V": 100, + "W": 59, + "Y": -11, +} + +# The Buriability values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods). +P8 = { + "A": 1.37, + "C": 8.93, + "D": -4.47, + "E": 4.04, + "F": -7.96, + "G": 3.39, + "H": -1.65, + "I": -7.92, + "K": 7.7, + "L": -8.68, + "M": -7.13, + "N": 6.29, + "P": 6.25, + "Q": 3.88, + "R": 1.33, + "S": 4.08, + "T": 4.02, + "V": -6.94, + "W": 0.79, + "Y": -4.73, +} + +# The Bulkiness for each of the 20 amino acids. +P9 = { + "A": 6.77, + "C": 8.57, + "D": 0.31, + "E": 12.93, + "F": 1.92, + "G": 7.95, + "H": 2.8, + "I": 2.72, + "K": 10.2, + "L": 4.43, + "M": 1.87, + "N": 5.5, + "P": 4.79, + "Q": 5.24, + "R": 6.87, + "S": 5.41, + "T": 5.36, + "V": 3.57, + "W": 0.54, + "Y": 2.26, +} + +# The Solvation_free_energy values are from JACS, 1962, 84: 4240-4246. (C. Tanford). +P10 = { + "A": 0.87, + "C": 0.66, + "D": 1.52, + "E": 0.67, + "F": 2.87, + "G": 0.1, + "H": 0.87, + "I": 3.15, + "K": 1.64, + "L": 2.17, + "M": 1.67, + "N": 0.09, + "P": 2.77, + "Q": 0, + "R": 0.85, + "S": 0.07, + "T": 0.07, + "V": 1.87, + "W": 3.77, + "Y": 2.67, +} + +# The Relative_mutability values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods). +P11 = { + "A": 1.09, + "C": 0.77, + "D": 0.5, + "E": 0.92, + "F": 0.5, + "G": 1.25, + "H": 0.67, + "I": 0.66, + "K": 1.25, + "L": 0.44, + "M": 0.45, + "N": 1.14, + "P": 2.96, + "Q": 0.83, + "R": 0.97, + "S": 1.21, + "T": 1.33, + "V": 0.56, + "W": 0.62, + "Y": 0.94, +} + +# The Residue_volume for each of the 20 amino acids. +P12 = { + "A": 0.91, + "C": 1.4, + "D": 0.93, + "E": 0.97, + "F": 0.72, + "G": 1.51, + "H": 0.9, + "I": 0.65, + "K": 0.82, + "L": 0.59, + "M": 0.58, + "N": 1.64, + "P": 1.66, + "Q": 0.94, + "R": 1, + "S": 1.23, + "T": 1.04, + "V": 0.6, + "W": 0.67, + "Y": 0.92, +} + +# The volume values are from JACS, 1962, 84: 4240-4246. (C. Tanford). +P13 = { + "A": 0.92, + "C": 0.48, + "D": 1.16, + "E": 0.61, + "F": 1.25, + "G": 0.61, + "H": 0.93, + "I": 1.81, + "K": 0.7, + "L": 1.3, + "M": 1.19, + "N": 0.6, + "P": 0.4, + "Q": 0.95, + "R": 0.93, + "S": 0.82, + "T": 1.12, + "V": 1.81, + "W": 1.54, + "Y": 1.53, +} + +# The Amino_acid_distribution values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods). +P14 = { + "A": 0.96, + "C": 0.9, + "D": 1.13, + "E": 0.33, + "F": 1.37, + "G": 0.9, + "H": 0.87, + "I": 1.54, + "K": 0.81, + "L": 1.26, + "M": 1.29, + "N": 0.72, + "P": 0.75, + "Q": 1.18, + "R": 0.67, + "S": 0.77, + "T": 1.23, + "V": 1.41, + "W": 1.13, + "Y": 1.07, +} + +# The Hydration_number for each of the 20 amino acids. +P15 = { + "A": 0.9, + "C": 0.47, + "D": 1.24, + "E": 0.62, + "F": 1.23, + "G": 0.56, + "H": 1.12, + "I": 1.54, + "K": 0.74, + "L": 1.26, + "M": 1.09, + "N": 0.62, + "P": 0.42, + "Q": 1.18, + "R": 1.02, + "S": 0.87, + "T": 1.3, + "V": 1.53, + "W": 1.75, + "Y": 1.68, +} + +# The Isoelectric_point values are from JACS, 1962, 84: 4240-4246. (C. Tanford). +P16 = { + "A": 6, + "C": 5.05, + "D": 2.77, + "E": 5.22, + "F": 5.48, + "G": 5.97, + "H": 7.59, + "I": 6.02, + "K": 9.74, + "L": 5.98, + "M": 5.74, + "N": 5.41, + "P": 6.3, + "Q": 5.65, + "R": 10.76, + "S": 5.68, + "T": 5.66, + "V": 5.96, + "W": 5.89, + "Y": 5.66, +} + +# The Compressibility values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods). +P17 = { + "A": -25.5, + "C": -32.82, + "D": -33.12, + "E": -36.17, + "F": -34.54, + "G": -27, + "H": -31.84, + "I": -31.78, + "K": -32.4, + "L": -31.78, + "M": -31.18, + "N": -30.9, + "P": -23.25, + "Q": -32.6, + "R": -26.62, + "S": -29.88, + "T": -31.23, + "V": -30.62, + "W": -30.24, + "Y": -35.01, +} + +# The Chromatographic_index for each of the 20 amino acids. +P18 = { + "A": 9.9, + "C": 2.8, + "D": 2.8, + "E": 3.2, + "F": 18.8, + "G": 5.6, + "H": 8.2, + "I": 17.1, + "K": 3.5, + "L": 17.6, + "M": 14.7, + "N": 5.4, + "P": 14.8, + "Q": 9, + "R": 4.6, + "S": 6.9, + "T": 9.5, + "V": 14.3, + "W": 17, + "Y": 15, +} + +# The Unfolding_entropy_change values are from JACS, 1962, 84: 4240-4246. (C. Tanford). +P19 = { + "A": 0.54, + "C": -4.14, + "D": -0.26, + "E": -0.19, + "F": -4.66, + "G": -0.31, + "H": -0.23, + "I": -0.27, + "K": 1.13, + "L": -0.24, + "M": -2.36, + "N": 1.74, + "P": -0.08, + "Q": 1.53, + "R": 3.69, + "S": -0.24, + "T": -0.28, + "V": -0.36, + "W": -2.69, + "Y": -2.82, +} + +# The Unfolding_entalpy_change values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods). +P20 = { + "A": 0.51, + "C": 5.21, + "D": 0.18, + "E": 0.05, + "F": 6.82, + "G": -0.23, + "H": 0.79, + "I": 0.19, + "K": -1.45, + "L": 0.17, + "M": 2.89, + "N": -2.03, + "P": 0.02, + "Q": -1.76, + "R": -4.4, + "S": -0.16, + "T": 0.04, + "V": 0.3, + "W": 4.47, + "Y": 3.73, +} + +# The Unfolding_Gibbs_free_energy_change for each of the 20 amino acids. +P21 = { + "A": -0.02, + "C": 1.08, + "D": -0.08, + "E": -0.13, + "F": 2.16, + "G": 0.09, + "H": 0.56, + "I": -0.08, + "K": -0.32, + "L": -0.08, + "M": 0.53, + "N": -0.3, + "P": -0.06, + "Q": -0.23, + "R": -0.71, + "S": -0.4, + "T": -0.24, + "V": -0.06, + "W": 1.78, + "Y": -0.91, +} + +# Normalized properties upto 3 decimal places +NP1 = { + "A": 0.636, + "C": 0.298, + "D": -0.924, + "E": -0.759, + "F": 1.221, + "G": 0.493, + "H": -0.41, + "I": 1.416, + "K": -1.539, + "L": 1.088, + "M": 0.657, + "N": -0.8, + "P": 0.123, + "Q": -0.872, + "R": -2.596, + "S": -0.185, + "T": -0.051, + "V": 1.108, + "W": 0.831, + "Y": 0.267, +} +NP2 = { + "A": -0.152, + "C": -0.418, + "D": 1.713, + "E": 1.713, + "F": -1.218, + "G": 0.115, + "H": -0.152, + "I": -0.845, + "K": 1.713, + "L": -0.845, + "M": -0.578, + "N": 0.221, + "P": 0.115, + "Q": 0.221, + "R": 1.713, + "S": 0.274, + "T": -0.099, + "V": -0.685, + "W": -1.697, + "Y": -1.111, +} +NP3 = { + "A": -1.592, + "C": -0.53, + "D": -0.131, + "E": 0.334, + "F": 0.931, + "G": -2.057, + "H": 0.632, + "I": -0.198, + "K": 0.334, + "L": -0.198, + "M": 0.4, + "N": -0.164, + "P": -0.696, + "Q": 0.3, + "R": 1.263, + "S": -1.061, + "T": -0.596, + "V": -0.662, + "W": 2.226, + "Y": 1.462, +} +NP4 = { + "A": 0.329, + "C": 1.417, + "D": -0.487, + "E": 1.417, + "F": -1.303, + "G": 0.057, + "H": -0.215, + "I": 1.036, + "K": 1.689, + "L": -0.922, + "M": -0.65, + "N": 0.166, + "P": -0.704, + "Q": 0.166, + "R": 1.689, + "S": 0.22, + "T": -0.16, + "V": -0.759, + "W": -1.792, + "Y": -1.194, +} +NP5 = { + "A": 1.755, + "C": 0.429, + "D": -1.365, + "E": 0.195, + "F": -0.585, + "G": 1.365, + "H": -1.287, + "I": 0.039, + "K": 0.819, + "L": 1.287, + "M": -1.521, + "N": -0.039, + "P": -0.429, + "Q": -0.507, + "R": -0.351, + "S": 1.131, + "T": 0.507, + "V": 0.897, + "W": -1.755, + "Y": -0.585, +} +NP6 = { + "A": -0.659, + "C": -1.007, + "D": 0.593, + "E": -1.633, + "F": 0.697, + "G": -0.416, + "H": -0.277, + "I": 1.671, + "K": -0.798, + "L": 0.836, + "M": 0.176, + "N": -1.32, + "P": -1.355, + "Q": -0.068, + "R": -0.52, + "S": -0.277, + "T": 0.628, + "V": 2.297, + "W": 0.628, + "Y": 0.802, +} +NP7 = { + "A": 0.735, + "C": -0.968, + "D": 1.372, + "E": -1.341, + "F": 1.108, + "G": -0.023, + "H": -0.704, + "I": 1.273, + "K": -0.166, + "L": 1.141, + "M": 0.955, + "N": -0.924, + "P": -0.77, + "Q": -1.429, + "R": -1.924, + "S": -0.276, + "T": 0.021, + "V": 1.196, + "W": 0.746, + "Y": -0.023, +} +NP8 = { + "A": 0.219, + "C": 1.552, + "D": -0.811, + "E": 0.69, + "F": -1.427, + "G": 0.575, + "H": -0.314, + "I": -1.42, + "K": 1.335, + "L": -1.554, + "M": -1.281, + "N": 1.087, + "P": 1.08, + "Q": 0.662, + "R": 0.212, + "S": 0.697, + "T": 0.686, + "V": -1.247, + "W": 0.117, + "Y": -0.857, +} +NP9 = { + "A": 0.56, + "C": 1.13, + "D": -1.484, + "E": 2.509, + "F": -0.975, + "G": 0.933, + "H": -0.696, + "I": -0.722, + "K": 1.645, + "L": -0.181, + "M": -0.991, + "N": 0.158, + "P": -0.067, + "Q": 0.076, + "R": 0.592, + "S": 0.13, + "T": 0.114, + "V": -0.453, + "W": -1.411, + "Y": -0.867, +} +NP10 = { + "A": -0.479, + "C": -0.663, + "D": 0.09, + "E": -0.654, + "F": 1.271, + "G": -1.153, + "H": -0.479, + "I": 1.516, + "K": 0.195, + "L": 0.658, + "M": 0.221, + "N": -1.161, + "P": 1.183, + "Q": -1.24, + "R": -0.496, + "S": -1.179, + "T": -1.179, + "V": 0.396, + "W": 2.058, + "Y": 1.096, +} +NP11 = { + "A": 0.253, + "C": -0.338, + "D": -0.836, + "E": -0.061, + "F": -0.836, + "G": 0.548, + "H": -0.522, + "I": -0.541, + "K": 0.548, + "L": -0.947, + "M": -0.928, + "N": 0.345, + "P": 3.703, + "Q": -0.227, + "R": 0.031, + "S": 0.474, + "T": 0.696, + "V": -0.725, + "W": -0.614, + "Y": -0.024, +} +NP12 = { + "A": -0.223, + "C": 1.256, + "D": -0.163, + "E": -0.042, + "F": -0.797, + "G": 1.588, + "H": -0.254, + "I": -1.008, + "K": -0.495, + "L": -1.189, + "M": -1.219, + "N": 1.98, + "P": 2.04, + "Q": -0.133, + "R": 0.048, + "S": 0.743, + "T": 0.169, + "V": -1.159, + "W": -0.948, + "Y": -0.193, +} +NP13 = { + "A": -0.277, + "C": -1.356, + "D": 0.311, + "E": -1.037, + "F": 0.532, + "G": -1.037, + "H": -0.253, + "I": 1.905, + "K": -0.816, + "L": 0.655, + "M": 0.385, + "N": -1.062, + "P": -1.552, + "Q": -0.203, + "R": -0.253, + "S": -0.522, + "T": 0.213, + "V": 1.905, + "W": 1.243, + "Y": 1.219, +} +NP14 = { + "A": -0.187, + "C": -0.393, + "D": 0.397, + "E": -2.352, + "F": 1.221, + "G": -0.393, + "H": -0.496, + "I": 1.805, + "K": -0.703, + "L": 0.843, + "M": 0.947, + "N": -1.012, + "P": -0.909, + "Q": 0.569, + "R": -1.184, + "S": -0.84, + "T": 0.74, + "V": 1.359, + "W": 0.397, + "Y": 0.191, +} +NP15 = { + "A": -0.402, + "C": -1.503, + "D": 0.469, + "E": -1.119, + "F": 0.443, + "G": -1.273, + "H": 0.161, + "I": 1.237, + "K": -0.812, + "L": 0.52, + "M": 0.085, + "N": -1.119, + "P": -1.631, + "Q": 0.315, + "R": -0.095, + "S": -0.479, + "T": 0.622, + "V": 1.211, + "W": 1.775, + "Y": 1.595, +} +NP16 = { + "A": -0.078, + "C": -0.667, + "D": -2.081, + "E": -0.562, + "F": -0.401, + "G": -0.097, + "H": 0.907, + "I": -0.066, + "K": 2.24, + "L": -0.091, + "M": -0.24, + "N": -0.444, + "P": 0.108, + "Q": -0.295, + "R": 2.872, + "S": -0.277, + "T": -0.289, + "V": -0.103, + "W": -0.147, + "Y": -0.289, +} +NP17 = { + "A": 1.728, + "C": -0.604, + "D": -0.7, + "E": -1.671, + "F": -1.152, + "G": 1.25, + "H": -0.292, + "I": -0.273, + "K": -0.47, + "L": -0.273, + "M": -0.082, + "N": 0.008, + "P": 2.445, + "Q": -0.534, + "R": 1.371, + "S": 0.333, + "T": -0.097, + "V": 0.097, + "W": 0.218, + "Y": -1.302, +} +NP18 = { + "A": -0.025, + "C": -1.322, + "D": -1.322, + "E": -1.249, + "F": 1.601, + "G": -0.81, + "H": -0.335, + "I": 1.291, + "K": -1.194, + "L": 1.382, + "M": 0.852, + "N": -0.847, + "P": 0.871, + "Q": -0.189, + "R": -0.993, + "S": -0.573, + "T": -0.098, + "V": 0.779, + "W": 1.273, + "Y": 0.907, +} +NP19 = { + "A": 0.549, + "C": -1.863, + "D": 0.137, + "E": 0.173, + "F": -2.131, + "G": 0.111, + "H": 0.152, + "I": 0.131, + "K": 0.853, + "L": 0.147, + "M": -0.946, + "N": 1.167, + "P": 0.229, + "Q": 1.059, + "R": 2.172, + "S": 0.147, + "T": 0.126, + "V": 0.085, + "W": -1.116, + "Y": -1.183, +} +NP20 = { + "A": -0.099, + "C": 1.717, + "D": -0.227, + "E": -0.277, + "F": 2.339, + "G": -0.385, + "H": 0.009, + "I": -0.223, + "K": -0.857, + "L": -0.231, + "M": 0.82, + "N": -1.081, + "P": -0.289, + "Q": -0.976, + "R": -1.996, + "S": -0.358, + "T": -0.281, + "V": -0.18, + "W": 1.431, + "Y": 1.145, +} +NP21 = { + "A": -0.2, + "C": 1.276, + "D": -0.28, + "E": -0.348, + "F": 2.725, + "G": -0.052, + "H": 0.578, + "I": -0.28, + "K": -0.602, + "L": -0.28, + "M": 0.538, + "N": -0.576, + "P": -0.254, + "Q": -0.482, + "R": -1.126, + "S": -0.71, + "T": -0.495, + "V": -0.254, + "W": 2.215, + "Y": -1.394, +} diff --git a/pyaptamer/AptaNet/pseaac.py b/pyaptamer/AptaNet/pseaac.py index 1bbb0955..160809f5 100644 --- a/pyaptamer/AptaNet/pseaac.py +++ b/pyaptamer/AptaNet/pseaac.py @@ -1,1031 +1,51 @@ +import numpy as np +from pyaptamer.AptaNet.utils import is_valid_aa +from pyaptamer.AptaNet._props import ( + NP1, NP2, NP3, NP4, NP5, NP6, NP7, NP8, NP9, + NP10, NP11, NP12, NP13, NP14, NP15, NP16, NP17, NP18, NP19, NP20, NP21 +) + class PSeAAC: """ Compute Pseudo Amino Acid Composition (PseAAC) features for a protein sequence. + This class generates a feature vector for a given protein sequence using selected + physicochemical properties and sequence-order information. + Parameters ---------- - protein_sequence : str - Protein sequence using single-letter amino acid codes. + None (see `vectorize` method for usage) Example ------- - >>> pse = PSeAAC("ACDEFGHIKLMNPQRSTVWY") - >>> features = pse.vectorize() + >>> pse = PSeAAC() + >>> features = pse.vectorize("ACDEFGHIKLMNPQRSTVWY") >>> print(features[:10]) [0.05, 0.05, 0.05, 0.05, 0.05, 0.05, 0.05, 0.05, 0.05, 0.05] + + Methods + ------- + vectorize(protein_sequence) + Generate the PseAAC feature vector for the given protein sequence. """ - def __init__(self, protein_sequence): + def __init__(self): """ Initialize PSeAAC with a protein sequence. - - Parameters - ---------- - protein_sequence : str - Protein sequence using single-letter amino acid codes. """ - self.protein_sequence = protein_sequence - self.amino_acid = list("ACDEFGHIKLMNPQRSTVWY") - - # The hydrophobicity values are from JACS, 1962, 84: 4240-4246. (C. Tanford). - self.P1 = { - "A": 0.62, - "C": 0.29, - "D": -0.90, - "E": -0.74, - "F": 1.19, - "G": 0.48, - "H": -0.40, - "I": 1.38, - "K": -1.50, - "L": 1.06, - "M": 0.64, - "N": -0.78, - "P": 0.12, - "Q": -0.85, - "R": -2.53, - "S": -0.18, - "T": -0.05, - "V": 1.08, - "W": 0.81, - "Y": 0.26, - } - - # The hydrophilicity values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods). - self.P2 = { - "A": -0.5, - "C": -1.0, - "D": 3.0, - "E": 3.0, - "F": -2.5, - "G": 0.0, - "H": -0.5, - "I": -1.8, - "K": 3.0, - "L": -1.8, - "M": -1.3, - "N": 0.2, - "P": 0.0, - "Q": 0.2, - "R": 3.0, - "S": 0.3, - "T": -0.4, - "V": -1.5, - "W": -3.4, - "Y": -2.3, - } - - # The side-chain mass for each of the 20 amino acids. - self.P3 = { - "A": 15.0, - "C": 47.0, - "D": 59.0, - "E": 73.0, - "F": 91.0, - "G": 1.0, - "H": 82.0, - "I": 57.0, - "K": 73.0, - "L": 57.0, - "M": 75.0, - "N": 58.0, - "P": 42.0, - "Q": 72.0, - "R": 101.0, - "S": 31.0, - "T": 45.0, - "V": 43.0, - "W": 130.0, - "Y": 107.0, - } - - # The Polarity values are from JACS, 1962, 84: 4240-4246. (C. Tanford). - self.P4 = { - "A": 0.5, - "C": 2.5, - "D": -1, - "E": 2.5, - "F": -2.5, - "G": 0, - "H": -0.5, - "I": 1.8, - "K": 3, - "L": -1.8, - "M": -1.3, - "N": 0.2, - "P": -1.4, - "Q": 0.2, - "R": 3, - "S": 0.3, - "T": -0.4, - "V": -1.5, - "W": -3.4, - "Y": -2.3, - } - - # The Molecular weight values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods). - self.P5 = { - "A": 5.3, - "C": 3.6, - "D": 1.3, - "E": 3.3, - "F": 2.3, - "G": 4.8, - "H": 1.4, - "I": 3.1, - "K": 4.1, - "L": 4.7, - "M": 1.1, - "N": 3, - "P": 2.5, - "Q": 2.4, - "R": 2.6, - "S": 4.5, - "T": 3.7, - "V": 4.2, - "W": 0.8, - "Y": 2.3, - } - - # The Meling point for each of the 20 amino acids. - self.P6 = { - "A": 0.81, - "C": 0.71, - "D": 1.17, - "E": 0.53, - "F": 1.2, - "G": 0.88, - "H": 0.92, - "I": 1.48, - "K": 0.77, - "L": 1.24, - "M": 1.05, - "N": 0.62, - "P": 0.61, - "Q": 0.98, - "R": 0.85, - "S": 0.92, - "T": 1.18, - "V": 1.66, - "W": 1.18, - "Y": 1.23, - } - - # The Transfer_free_energy values are from JACS, 1962, 84: 4240-4246. (C. Tanford). - self.P7 = { - "A": 58, - "C": -97, - "D": 116, - "E": -131, - "F": 92, - "G": -11, - "H": -73, - "I": 107, - "K": -24, - "L": 95, - "M": 78, - "N": -93, - "P": -79, - "Q": -139, - "R": -184, - "S": -34, - "T": -7, - "V": 100, - "W": 59, - "Y": -11, - } - - # The Buriability values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods). - self.P8 = { - "A": 1.37, - "C": 8.93, - "D": -4.47, - "E": 4.04, - "F": -7.96, - "G": 3.39, - "H": -1.65, - "I": -7.92, - "K": 7.7, - "L": -8.68, - "M": -7.13, - "N": 6.29, - "P": 6.25, - "Q": 3.88, - "R": 1.33, - "S": 4.08, - "T": 4.02, - "V": -6.94, - "W": 0.79, - "Y": -4.73, - } - - # The Bulkiness for each of the 20 amino acids. - self.P9 = { - "A": 6.77, - "C": 8.57, - "D": 0.31, - "E": 12.93, - "F": 1.92, - "G": 7.95, - "H": 2.8, - "I": 2.72, - "K": 10.2, - "L": 4.43, - "M": 1.87, - "N": 5.5, - "P": 4.79, - "Q": 5.24, - "R": 6.87, - "S": 5.41, - "T": 5.36, - "V": 3.57, - "W": 0.54, - "Y": 2.26, - } - - # The Solvation_free_energy values are from JACS, 1962, 84: 4240-4246. (C. Tanford). - self.P10 = { - "A": 0.87, - "C": 0.66, - "D": 1.52, - "E": 0.67, - "F": 2.87, - "G": 0.1, - "H": 0.87, - "I": 3.15, - "K": 1.64, - "L": 2.17, - "M": 1.67, - "N": 0.09, - "P": 2.77, - "Q": 0, - "R": 0.85, - "S": 0.07, - "T": 0.07, - "V": 1.87, - "W": 3.77, - "Y": 2.67, - } - - # The Relative_mutability values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods). - self.P11 = { - "A": 1.09, - "C": 0.77, - "D": 0.5, - "E": 0.92, - "F": 0.5, - "G": 1.25, - "H": 0.67, - "I": 0.66, - "K": 1.25, - "L": 0.44, - "M": 0.45, - "N": 1.14, - "P": 2.96, - "Q": 0.83, - "R": 0.97, - "S": 1.21, - "T": 1.33, - "V": 0.56, - "W": 0.62, - "Y": 0.94, - } - - # The Residue_volume for each of the 20 amino acids. - self.P12 = { - "A": 0.91, - "C": 1.4, - "D": 0.93, - "E": 0.97, - "F": 0.72, - "G": 1.51, - "H": 0.9, - "I": 0.65, - "K": 0.82, - "L": 0.59, - "M": 0.58, - "N": 1.64, - "P": 1.66, - "Q": 0.94, - "R": 1, - "S": 1.23, - "T": 1.04, - "V": 0.6, - "W": 0.67, - "Y": 0.92, - } - - # The volume values are from JACS, 1962, 84: 4240-4246. (C. Tanford). - self.P13 = { - "A": 0.92, - "C": 0.48, - "D": 1.16, - "E": 0.61, - "F": 1.25, - "G": 0.61, - "H": 0.93, - "I": 1.81, - "K": 0.7, - "L": 1.3, - "M": 1.19, - "N": 0.6, - "P": 0.4, - "Q": 0.95, - "R": 0.93, - "S": 0.82, - "T": 1.12, - "V": 1.81, - "W": 1.54, - "Y": 1.53, - } - - # The Amino_acid_distribution values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods). - self.P14 = { - "A": 0.96, - "C": 0.9, - "D": 1.13, - "E": 0.33, - "F": 1.37, - "G": 0.9, - "H": 0.87, - "I": 1.54, - "K": 0.81, - "L": 1.26, - "M": 1.29, - "N": 0.72, - "P": 0.75, - "Q": 1.18, - "R": 0.67, - "S": 0.77, - "T": 1.23, - "V": 1.41, - "W": 1.13, - "Y": 1.07, - } - - # The Hydration_number for each of the 20 amino acids. - self.P15 = { - "A": 0.9, - "C": 0.47, - "D": 1.24, - "E": 0.62, - "F": 1.23, - "G": 0.56, - "H": 1.12, - "I": 1.54, - "K": 0.74, - "L": 1.26, - "M": 1.09, - "N": 0.62, - "P": 0.42, - "Q": 1.18, - "R": 1.02, - "S": 0.87, - "T": 1.3, - "V": 1.53, - "W": 1.75, - "Y": 1.68, - } - - # The Isoelectric_point values are from JACS, 1962, 84: 4240-4246. (C. Tanford). - self.P16 = { - "A": 6, - "C": 5.05, - "D": 2.77, - "E": 5.22, - "F": 5.48, - "G": 5.97, - "H": 7.59, - "I": 6.02, - "K": 9.74, - "L": 5.98, - "M": 5.74, - "N": 5.41, - "P": 6.3, - "Q": 5.65, - "R": 10.76, - "S": 5.68, - "T": 5.66, - "V": 5.96, - "W": 5.89, - "Y": 5.66, - } - - # The Compressibility values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods). - self.P17 = { - "A": -25.5, - "C": -32.82, - "D": -33.12, - "E": -36.17, - "F": -34.54, - "G": -27, - "H": -31.84, - "I": -31.78, - "K": -32.4, - "L": -31.78, - "M": -31.18, - "N": -30.9, - "P": -23.25, - "Q": -32.6, - "R": -26.62, - "S": -29.88, - "T": -31.23, - "V": -30.62, - "W": -30.24, - "Y": -35.01, - } - - # The Chromatographic_index for each of the 20 amino acids. - self.P18 = { - "A": 9.9, - "C": 2.8, - "D": 2.8, - "E": 3.2, - "F": 18.8, - "G": 5.6, - "H": 8.2, - "I": 17.1, - "K": 3.5, - "L": 17.6, - "M": 14.7, - "N": 5.4, - "P": 14.8, - "Q": 9, - "R": 4.6, - "S": 6.9, - "T": 9.5, - "V": 14.3, - "W": 17, - "Y": 15, - } - - # The Unfolding_entropy_change values are from JACS, 1962, 84: 4240-4246. (C. Tanford). - self.P19 = { - "A": 0.54, - "C": -4.14, - "D": -0.26, - "E": -0.19, - "F": -4.66, - "G": -0.31, - "H": -0.23, - "I": -0.27, - "K": 1.13, - "L": -0.24, - "M": -2.36, - "N": 1.74, - "P": -0.08, - "Q": 1.53, - "R": 3.69, - "S": -0.24, - "T": -0.28, - "V": -0.36, - "W": -2.69, - "Y": -2.82, - } - - # The Unfolding_entalpy_change values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods). - self.P20 = { - "A": 0.51, - "C": 5.21, - "D": 0.18, - "E": 0.05, - "F": 6.82, - "G": -0.23, - "H": 0.79, - "I": 0.19, - "K": -1.45, - "L": 0.17, - "M": 2.89, - "N": -2.03, - "P": 0.02, - "Q": -1.76, - "R": -4.4, - "S": -0.16, - "T": 0.04, - "V": 0.3, - "W": 4.47, - "Y": 3.73, - } - - # The Unfolding_Gibbs_free_energy_change for each of the 20 amino acids. - self.P21 = { - "A": -0.02, - "C": 1.08, - "D": -0.08, - "E": -0.13, - "F": 2.16, - "G": 0.09, - "H": 0.56, - "I": -0.08, - "K": -0.32, - "L": -0.08, - "M": 0.53, - "N": -0.3, - "P": -0.06, - "Q": -0.23, - "R": -0.71, - "S": -0.4, - "T": -0.24, - "V": -0.06, - "W": 1.78, - "Y": -0.91, - } - - # Normalized properties upto 3 decimal places - self.NP1 = { - "A": 0.636, - "C": 0.298, - "D": -0.924, - "E": -0.759, - "F": 1.221, - "G": 0.493, - "H": -0.41, - "I": 1.416, - "K": -1.539, - "L": 1.088, - "M": 0.657, - "N": -0.8, - "P": 0.123, - "Q": -0.872, - "R": -2.596, - "S": -0.185, - "T": -0.051, - "V": 1.108, - "W": 0.831, - "Y": 0.267, - } - self.NP2 = { - "A": -0.152, - "C": -0.418, - "D": 1.713, - "E": 1.713, - "F": -1.218, - "G": 0.115, - "H": -0.152, - "I": -0.845, - "K": 1.713, - "L": -0.845, - "M": -0.578, - "N": 0.221, - "P": 0.115, - "Q": 0.221, - "R": 1.713, - "S": 0.274, - "T": -0.099, - "V": -0.685, - "W": -1.697, - "Y": -1.111, - } - self.NP3 = { - "A": -1.592, - "C": -0.53, - "D": -0.131, - "E": 0.334, - "F": 0.931, - "G": -2.057, - "H": 0.632, - "I": -0.198, - "K": 0.334, - "L": -0.198, - "M": 0.4, - "N": -0.164, - "P": -0.696, - "Q": 0.3, - "R": 1.263, - "S": -1.061, - "T": -0.596, - "V": -0.662, - "W": 2.226, - "Y": 1.462, - } - self.NP4 = { - "A": 0.329, - "C": 1.417, - "D": -0.487, - "E": 1.417, - "F": -1.303, - "G": 0.057, - "H": -0.215, - "I": 1.036, - "K": 1.689, - "L": -0.922, - "M": -0.65, - "N": 0.166, - "P": -0.704, - "Q": 0.166, - "R": 1.689, - "S": 0.22, - "T": -0.16, - "V": -0.759, - "W": -1.792, - "Y": -1.194, - } - self.NP5 = { - "A": 1.755, - "C": 0.429, - "D": -1.365, - "E": 0.195, - "F": -0.585, - "G": 1.365, - "H": -1.287, - "I": 0.039, - "K": 0.819, - "L": 1.287, - "M": -1.521, - "N": -0.039, - "P": -0.429, - "Q": -0.507, - "R": -0.351, - "S": 1.131, - "T": 0.507, - "V": 0.897, - "W": -1.755, - "Y": -0.585, - } - self.NP6 = { - "A": -0.659, - "C": -1.007, - "D": 0.593, - "E": -1.633, - "F": 0.697, - "G": -0.416, - "H": -0.277, - "I": 1.671, - "K": -0.798, - "L": 0.836, - "M": 0.176, - "N": -1.32, - "P": -1.355, - "Q": -0.068, - "R": -0.52, - "S": -0.277, - "T": 0.628, - "V": 2.297, - "W": 0.628, - "Y": 0.802, - } - self.NP7 = { - "A": 0.735, - "C": -0.968, - "D": 1.372, - "E": -1.341, - "F": 1.108, - "G": -0.023, - "H": -0.704, - "I": 1.273, - "K": -0.166, - "L": 1.141, - "M": 0.955, - "N": -0.924, - "P": -0.77, - "Q": -1.429, - "R": -1.924, - "S": -0.276, - "T": 0.021, - "V": 1.196, - "W": 0.746, - "Y": -0.023, - } - self.NP8 = { - "A": 0.219, - "C": 1.552, - "D": -0.811, - "E": 0.69, - "F": -1.427, - "G": 0.575, - "H": -0.314, - "I": -1.42, - "K": 1.335, - "L": -1.554, - "M": -1.281, - "N": 1.087, - "P": 1.08, - "Q": 0.662, - "R": 0.212, - "S": 0.697, - "T": 0.686, - "V": -1.247, - "W": 0.117, - "Y": -0.857, - } - self.NP9 = { - "A": 0.56, - "C": 1.13, - "D": -1.484, - "E": 2.509, - "F": -0.975, - "G": 0.933, - "H": -0.696, - "I": -0.722, - "K": 1.645, - "L": -0.181, - "M": -0.991, - "N": 0.158, - "P": -0.067, - "Q": 0.076, - "R": 0.592, - "S": 0.13, - "T": 0.114, - "V": -0.453, - "W": -1.411, - "Y": -0.867, - } - self.NP10 = { - "A": -0.479, - "C": -0.663, - "D": 0.09, - "E": -0.654, - "F": 1.271, - "G": -1.153, - "H": -0.479, - "I": 1.516, - "K": 0.195, - "L": 0.658, - "M": 0.221, - "N": -1.161, - "P": 1.183, - "Q": -1.24, - "R": -0.496, - "S": -1.179, - "T": -1.179, - "V": 0.396, - "W": 2.058, - "Y": 1.096, - } - self.NP11 = { - "A": 0.253, - "C": -0.338, - "D": -0.836, - "E": -0.061, - "F": -0.836, - "G": 0.548, - "H": -0.522, - "I": -0.541, - "K": 0.548, - "L": -0.947, - "M": -0.928, - "N": 0.345, - "P": 3.703, - "Q": -0.227, - "R": 0.031, - "S": 0.474, - "T": 0.696, - "V": -0.725, - "W": -0.614, - "Y": -0.024, - } - self.NP12 = { - "A": -0.223, - "C": 1.256, - "D": -0.163, - "E": -0.042, - "F": -0.797, - "G": 1.588, - "H": -0.254, - "I": -1.008, - "K": -0.495, - "L": -1.189, - "M": -1.219, - "N": 1.98, - "P": 2.04, - "Q": -0.133, - "R": 0.048, - "S": 0.743, - "T": 0.169, - "V": -1.159, - "W": -0.948, - "Y": -0.193, - } - self.NP13 = { - "A": -0.277, - "C": -1.356, - "D": 0.311, - "E": -1.037, - "F": 0.532, - "G": -1.037, - "H": -0.253, - "I": 1.905, - "K": -0.816, - "L": 0.655, - "M": 0.385, - "N": -1.062, - "P": -1.552, - "Q": -0.203, - "R": -0.253, - "S": -0.522, - "T": 0.213, - "V": 1.905, - "W": 1.243, - "Y": 1.219, - } - self.NP14 = { - "A": -0.187, - "C": -0.393, - "D": 0.397, - "E": -2.352, - "F": 1.221, - "G": -0.393, - "H": -0.496, - "I": 1.805, - "K": -0.703, - "L": 0.843, - "M": 0.947, - "N": -1.012, - "P": -0.909, - "Q": 0.569, - "R": -1.184, - "S": -0.84, - "T": 0.74, - "V": 1.359, - "W": 0.397, - "Y": 0.191, - } - self.NP15 = { - "A": -0.402, - "C": -1.503, - "D": 0.469, - "E": -1.119, - "F": 0.443, - "G": -1.273, - "H": 0.161, - "I": 1.237, - "K": -0.812, - "L": 0.52, - "M": 0.085, - "N": -1.119, - "P": -1.631, - "Q": 0.315, - "R": -0.095, - "S": -0.479, - "T": 0.622, - "V": 1.211, - "W": 1.775, - "Y": 1.595, - } - self.NP16 = { - "A": -0.078, - "C": -0.667, - "D": -2.081, - "E": -0.562, - "F": -0.401, - "G": -0.097, - "H": 0.907, - "I": -0.066, - "K": 2.24, - "L": -0.091, - "M": -0.24, - "N": -0.444, - "P": 0.108, - "Q": -0.295, - "R": 2.872, - "S": -0.277, - "T": -0.289, - "V": -0.103, - "W": -0.147, - "Y": -0.289, - } - self.NP17 = { - "A": 1.728, - "C": -0.604, - "D": -0.7, - "E": -1.671, - "F": -1.152, - "G": 1.25, - "H": -0.292, - "I": -0.273, - "K": -0.47, - "L": -0.273, - "M": -0.082, - "N": 0.008, - "P": 2.445, - "Q": -0.534, - "R": 1.371, - "S": 0.333, - "T": -0.097, - "V": 0.097, - "W": 0.218, - "Y": -1.302, - } - self.NP18 = { - "A": -0.025, - "C": -1.322, - "D": -1.322, - "E": -1.249, - "F": 1.601, - "G": -0.81, - "H": -0.335, - "I": 1.291, - "K": -1.194, - "L": 1.382, - "M": 0.852, - "N": -0.847, - "P": 0.871, - "Q": -0.189, - "R": -0.993, - "S": -0.573, - "T": -0.098, - "V": 0.779, - "W": 1.273, - "Y": 0.907, - } - self.NP19 = { - "A": 0.549, - "C": -1.863, - "D": 0.137, - "E": 0.173, - "F": -2.131, - "G": 0.111, - "H": 0.152, - "I": 0.131, - "K": 0.853, - "L": 0.147, - "M": -0.946, - "N": 1.167, - "P": 0.229, - "Q": 1.059, - "R": 2.172, - "S": 0.147, - "T": 0.126, - "V": 0.085, - "W": -1.116, - "Y": -1.183, - } - self.NP20 = { - "A": -0.099, - "C": 1.717, - "D": -0.227, - "E": -0.277, - "F": 2.339, - "G": -0.385, - "H": 0.009, - "I": -0.223, - "K": -0.857, - "L": -0.231, - "M": 0.82, - "N": -1.081, - "P": -0.289, - "Q": -0.976, - "R": -1.996, - "S": -0.358, - "T": -0.281, - "V": -0.18, - "W": 1.431, - "Y": 1.145, - } - self.NP21 = { - "A": -0.2, - "C": 1.276, - "D": -0.28, - "E": -0.348, - "F": 2.725, - "G": -0.052, - "H": 0.578, - "I": -0.28, - "K": -0.602, - "L": -0.28, - "M": 0.538, - "N": -0.576, - "P": -0.254, - "Q": -0.482, - "R": -1.126, - "S": -0.71, - "T": -0.495, - "V": -0.254, - "W": 2.215, - "Y": -1.394, - } + self.amino_acid = set("ACDEFGHIKLMNPQRSTVWY") # Define 7 selected groups of 3 properties each self.prop_groups = [ - (self.NP1, self.NP2, self.NP3), - (self.NP4, self.NP5, self.NP6), - (self.NP7, self.NP8, self.NP9), - (self.NP10, self.NP11, self.NP12), - (self.NP13, self.NP14, self.NP15), - (self.NP16, self.NP17, self.NP18), - (self.NP19, self.NP20, self.NP21), + (NP1, NP2, NP3), + (NP4, NP5, NP6), + (NP7, NP8, NP9), + (NP10, NP11, NP12), + (NP13, NP14, NP15), + (NP16, NP17, NP18), + (NP19, NP20, NP21), ] - def _check_validity(self, seq): - """ - Check if the sequence contains only valid amino acids. - - Parameters - ---------- - seq : str - Protein sequence. - - Raises - ------ - ValueError - If an invalid amino acid is found. - """ - for aa in seq: - if aa not in self.amino_acid: - raise ValueError( - f"Invalid amino acid '{aa}' found in protein_sequence. Only {self.amino_acid} are allowed." - ) - # Function to average the amino acid composition def _average_aa(self, seq): """ @@ -1041,13 +61,11 @@ def _average_aa(self, seq): dict Dictionary mapping amino acid to its average frequency. """ - count = {aa: 0 for aa in self.amino_acid} - for aa in seq: - if aa in count: - count[aa] += 1 - total = len(self.amino_acid) + from collections import Counter - return {aa: count[aa] / total if total > 0 else 0 for aa in count} + counts = Counter(seq) + total = len(self.amino_acid) + return {aa: counts.get(aa, 0) / total if total > 0 else 0 for aa in self.amino_acid} def _theta_RiRj(self, Ri, Rj, prop_group): """ @@ -1067,7 +85,8 @@ def _theta_RiRj(self, Ri, Rj, prop_group): float Theta value. """ - return sum((prop[Rj] - prop[Ri]) ** 2 for prop in prop_group) / len(prop_group) + diffs = np.array([prop[Rj] - prop[Ri] for prop in prop_group], dtype=float) + return np.mean(diffs ** 2) def _sum_theta_val(self, seq, seq_len, lambda_val, n, prop_group): """ @@ -1096,51 +115,43 @@ def _sum_theta_val(self, seq, seq_len, lambda_val, n, prop_group): for i in range(seq_len - lambda_val) ) / (seq_len - n) - def vectorize(self): + def vectorize(self, protein_sequence): """ Generate the PseAAC feature vector for the protein sequence. - - Returns - ------- - list of float - PseAAC feature vector. """ - self._check_validity(self.protein_sequence) + if not is_valid_aa(protein_sequence): + raise ValueError( + f"Invalid amino acid found in protein_sequence. Only {''.join(sorted(self.amino_acid))} are allowed." + ) lambda_val = 30 weight = 0.15 all_pseaac = [] - if len(self.protein_sequence) <= lambda_val: + seq_len = len(protein_sequence) + if seq_len <= lambda_val: raise ValueError( f"Sequence too short for Lambda={lambda_val}. Must be > {lambda_val}." ) for prop_group in self.prop_groups: - aa_freq = self._average_aa(self.protein_sequence) + aa_freq = self._average_aa(protein_sequence) sum_all_aa_freq = sum(aa_freq.values()) - all_theta_val = [] - sum_all_theta_val = 0 - for n in range(1, lambda_val + 1): - theta_val = self._sum_theta_val( - self.protein_sequence, - len(self.protein_sequence), - lambda_val, - n, - prop_group, - ) - all_theta_val.append(theta_val) - sum_all_theta_val += theta_val + all_theta_val = np.array([ + self._sum_theta_val(protein_sequence, seq_len, lambda_val, n, prop_group) + for n in range(1, lambda_val + 1) + ]) + sum_all_theta_val = np.sum(all_theta_val) denominator_val = sum_all_aa_freq + (weight * sum_all_theta_val) print(f"Denominator value: {denominator_val}") + # First 20 features: normalized amino acid composition - for aa in self.amino_acid: - all_pseaac.append(round((aa_freq[aa] / denominator_val), 3)) + aa_composition = np.array([aa_freq[aa] for aa in self.amino_acid]) + all_pseaac.extend(np.round(aa_composition / denominator_val, 3)) # Next 30 features: theta values - for theta_val in all_theta_val: - all_pseaac.append(round((weight * theta_val / denominator_val), 3)) + all_pseaac.extend(np.round((weight * all_theta_val) / denominator_val, 3)) - return all_pseaac + return all_pseaac \ No newline at end of file diff --git a/pyaptamer/AptaNet/test_pseaac.py b/pyaptamer/AptaNet/test_pseaac.py index 457d24fc..459eb45e 100644 --- a/pyaptamer/AptaNet/test_pseaac.py +++ b/pyaptamer/AptaNet/test_pseaac.py @@ -415,8 +415,8 @@ def test_pseaac_vectorization(seq, expected_vector): ------- The produced vector matches the expected vector in length and values (within tolerance). """ - p = PSeAAC(seq) - pv = p.vectorize() + p = PSeAAC() + pv = p.vectorize(seq) assert len(pv) == len(expected_vector), ( f"Vector length mismatch: {len(pv)} != {len(expected_vector)}" diff --git a/pyaptamer/AptaNet/utils.py b/pyaptamer/AptaNet/utils.py new file mode 100644 index 00000000..761d8b59 --- /dev/null +++ b/pyaptamer/AptaNet/utils.py @@ -0,0 +1,17 @@ +AMINO_ACIDS = set("ACDEFGHIKLMNPQRSTVWY") + +def is_valid_aa(seq): + """ + Check if the sequence contains only valid amino acids. + + Parameters + ---------- + seq : str + Protein sequence. + + Returns + ------- + bool + True if all characters are valid amino acids, False otherwise. + """ + return all(aa in AMINO_ACIDS for aa in seq) \ No newline at end of file From 733f9080d75808272de28098e0840ce9b31c95d3 Mon Sep 17 00:00:00 2001 From: satvshr Date: Thu, 10 Jul 2025 13:32:57 +0530 Subject: [PATCH 013/145] Made requested changes and updated tests --- pyaptamer/AptaNet/_props.py | 30 +++++++- pyaptamer/AptaNet/pseaac.py | 68 ++++++++++++------ pyaptamer/AptaNet/test_pseaac.py | 119 +++++++++++++++++++++++++++---- pyaptamer/AptaNet/utils.py | 17 ++++- pyproject.toml | 2 +- 5 files changed, 197 insertions(+), 39 deletions(-) diff --git a/pyaptamer/AptaNet/_props.py b/pyaptamer/AptaNet/_props.py index af3a5bfb..e2dccf63 100644 --- a/pyaptamer/AptaNet/_props.py +++ b/pyaptamer/AptaNet/_props.py @@ -1,3 +1,24 @@ +""" +Amino acid physicochemical property constants for PSeAAC. + +This module provides hard-coded dictionaries for 21 different physicochemical +properties (P1–P21) of the 20 standard amino acids, as well as their normalized +versions (NP1–NP21). + +Each Pi dictionary maps single-letter amino acid codes to a specific property +value. The properties include hydrophobicity, hydrophilicity, side-chain mass, +polarity, molecular weight, melting point, transfer free energy, buriability, +bulkiness, solvation free energy, relative mutability, residue volume, volume, +amino acid distribution, hydration number, isoelectric point, compressibility, +chromatographic index, unfolding entropy change, unfolding enthalpy change, +and unfolding Gibbs free energy change. + +Each NPi dictionary contains the z-score normalized values of the corresponding +Pi property, rounded to three decimal places, for use in feature calculations. + +These constants are intended for internal use by the PSeAAC feature generator. +""" + # The hydrophobicity values are from JACS, 1962, 84: 4240-4246. (C. Tanford). P1 = { "A": 0.62, @@ -238,7 +259,8 @@ "Y": 2.67, } -# The Relative_mutability values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods). +# The Relative_mutability values are from PNAS, 1981, 78:3824-3828 +# (T.P.Hopp & K.R.Woods). P11 = { "A": 1.09, "C": 0.77, @@ -310,7 +332,8 @@ "Y": 1.53, } -# The Amino_acid_distribution values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods). +# The Amino_acid_distribution values are from PNAS, 1981, 78:3824-3828 +# (T.P.Hopp & K.R.Woods). P14 = { "A": 0.96, "C": 0.9, @@ -454,7 +477,8 @@ "Y": -2.82, } -# The Unfolding_entalpy_change values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods). +# The Unfolding_entalpy_change values are from PNAS, 1981, 78:3824-3828 +# (T.P.Hopp & K.R.Woods). P20 = { "A": 0.51, "C": 5.21, diff --git a/pyaptamer/AptaNet/pseaac.py b/pyaptamer/AptaNet/pseaac.py index 160809f5..ede79c61 100644 --- a/pyaptamer/AptaNet/pseaac.py +++ b/pyaptamer/AptaNet/pseaac.py @@ -1,9 +1,29 @@ import numpy as np -from pyaptamer.AptaNet.utils import is_valid_aa -from pyaptamer.AptaNet._props import ( - NP1, NP2, NP3, NP4, NP5, NP6, NP7, NP8, NP9, - NP10, NP11, NP12, NP13, NP14, NP15, NP16, NP17, NP18, NP19, NP20, NP21 +from _props import ( + NP1, + NP2, + NP3, + NP4, + NP5, + NP6, + NP7, + NP8, + NP9, + NP10, + NP11, + NP12, + NP13, + NP14, + NP15, + NP16, + NP17, + NP18, + NP19, + NP20, + NP21, ) +from utils import is_valid_aa + class PSeAAC: """ @@ -14,18 +34,18 @@ class PSeAAC: Parameters ---------- - None (see `vectorize` method for usage) + None (see `transform` method for usage) Example ------- >>> pse = PSeAAC() - >>> features = pse.vectorize("ACDEFGHIKLMNPQRSTVWY") + >>> features = pse.transform("ACDEFGHIKLMNPQRSTVWY") >>> print(features[:10]) [0.05, 0.05, 0.05, 0.05, 0.05, 0.05, 0.05, 0.05, 0.05, 0.05] Methods ------- - vectorize(protein_sequence) + transform(protein_sequence) Generate the PseAAC feature vector for the given protein sequence. """ @@ -65,17 +85,19 @@ def _average_aa(self, seq): counts = Counter(seq) total = len(self.amino_acid) - return {aa: counts.get(aa, 0) / total if total > 0 else 0 for aa in self.amino_acid} + return { + aa: counts.get(aa, 0) / total if total > 0 else 0 for aa in self.amino_acid + } - def _theta_RiRj(self, Ri, Rj, prop_group): + def _theta_rirj(self, ri, rj, prop_group): """ Compute the theta value between two amino acids for a group of properties. Parameters ---------- - Ri : str + ri : str First amino acid. - Rj : str + rj : str Second amino acid. prop_group : tuple of dict Tuple of property dictionaries. @@ -85,8 +107,8 @@ def _theta_RiRj(self, Ri, Rj, prop_group): float Theta value. """ - diffs = np.array([prop[Rj] - prop[Ri] for prop in prop_group], dtype=float) - return np.mean(diffs ** 2) + diffs = np.array([prop[rj] - prop[ri] for prop in prop_group], dtype=float) + return np.mean(diffs**2) def _sum_theta_val(self, seq, seq_len, lambda_val, n, prop_group): """ @@ -115,13 +137,14 @@ def _sum_theta_val(self, seq, seq_len, lambda_val, n, prop_group): for i in range(seq_len - lambda_val) ) / (seq_len - n) - def vectorize(self, protein_sequence): + def transform(self, protein_sequence): """ Generate the PseAAC feature vector for the protein sequence. """ if not is_valid_aa(protein_sequence): raise ValueError( - f"Invalid amino acid found in protein_sequence. Only {''.join(sorted(self.amino_acid))} are allowed." + "Invalid amino acid found in protein_sequence. Only " + f"{''.join(sorted(self.amino_acid))} are allowed." ) lambda_val = 30 @@ -138,14 +161,17 @@ def vectorize(self, protein_sequence): aa_freq = self._average_aa(protein_sequence) sum_all_aa_freq = sum(aa_freq.values()) - all_theta_val = np.array([ - self._sum_theta_val(protein_sequence, seq_len, lambda_val, n, prop_group) - for n in range(1, lambda_val + 1) - ]) + all_theta_val = np.array( + [ + self._sum_theta_val( + protein_sequence, seq_len, lambda_val, n, prop_group + ) + for n in range(1, lambda_val + 1) + ] + ) sum_all_theta_val = np.sum(all_theta_val) denominator_val = sum_all_aa_freq + (weight * sum_all_theta_val) - print(f"Denominator value: {denominator_val}") # First 20 features: normalized amino acid composition aa_composition = np.array([aa_freq[aa] for aa in self.amino_acid]) @@ -154,4 +180,4 @@ def vectorize(self, protein_sequence): # Next 30 features: theta values all_pseaac.extend(np.round((weight * all_theta_val) / denominator_val, 3)) - return all_pseaac \ No newline at end of file + return all_pseaac diff --git a/pyaptamer/AptaNet/test_pseaac.py b/pyaptamer/AptaNet/test_pseaac.py index 459eb45e..f6bb277b 100644 --- a/pyaptamer/AptaNet/test_pseaac.py +++ b/pyaptamer/AptaNet/test_pseaac.py @@ -1,11 +1,56 @@ import numpy as np import pytest +from _props import ( + NP1, + NP2, + NP3, + NP4, + NP5, + NP6, + NP7, + NP8, + NP9, + NP10, + NP11, + NP12, + NP13, + NP14, + NP15, + NP16, + NP17, + NP18, + NP19, + NP20, + NP21, + P1, + P2, + P3, + P4, + P5, + P6, + P7, + P8, + P9, + P10, + P11, + P12, + P13, + P14, + P15, + P16, + P17, + P18, + P19, + P20, + P21, +) from pseaac import PSeAAC def _normalize_properties(property_dicts): """ - Takes multiple amino acid property dictionaries and returns their normalized versions. + Takes multiple amino acid property dictionaries and returns their + normalized versions. Normalization: (value - mean) / std deviation Returns a list of normalized dictionaries in the same order. """ @@ -26,20 +71,67 @@ def test_normalized_values(): Asserts ------- - All normalized property values match the corresponding NP values for each amino acid. + All normalized property values match the corresponding NP values + for each amino acid. """ - apt = PSeAAC("ACDEFGHIKLMNPQRSTVWY") - P_props = [getattr(apt, f"P{i}") for i in range(1, 21)] - normalized = _normalize_properties(P_props) - for i in range(1, 21): - np_dict = getattr(apt, f"NP{i}") - norm_dict = normalized[i - 1] + # Use the imported P1-P21 and NP1-NP21 from _props + p_props = [ + P1, + P2, + P3, + P4, + P5, + P6, + P7, + P8, + P9, + P10, + P11, + P12, + P13, + P14, + P15, + P16, + P17, + P18, + P19, + P20, + P21, + ] + np_props = [ + NP1, + NP2, + NP3, + NP4, + NP5, + NP6, + NP7, + NP8, + NP9, + NP10, + NP11, + NP12, + NP13, + NP14, + NP15, + NP16, + NP17, + NP18, + NP19, + NP20, + NP21, + ] + normalized = _normalize_properties(p_props) + for i in range(21): + np_dict = np_props[i] + norm_dict = normalized[i] for aa in np_dict: assert np_dict[aa] == norm_dict[aa], ( - f"Mismatch in NP{i} for {aa}: {np_dict[aa]} != {norm_dict[aa]}" + f"Mismatch in NP{i + 1} for {aa}: {np_dict[aa]} != {norm_dict[aa]}" ) +@pytest.mark.skip(reason="Pending issue #34") @pytest.mark.parametrize( "seq,expected_vector", [ @@ -407,23 +499,24 @@ def test_pseaac_vectorization(seq, expected_vector): Parameters ---------- seq : str - Protein sequence to vectorize. + Protein sequence to transform. expected_vector : list of float Expected PSeAAC feature vector. Asserts ------- - The produced vector matches the expected vector in length and values (within tolerance). + The produced vector matches the expected vector in + length and values (within tolerance). """ p = PSeAAC() - pv = p.vectorize(seq) + pv = p.transform(seq) assert len(pv) == len(expected_vector), ( f"Vector length mismatch: {len(pv)} != {len(expected_vector)}" ) mismatches = [ (i, a, b) - for i, (a, b) in enumerate(zip(pv, expected_vector)) + for i, (a, b) in enumerate(zip(pv, expected_vector, strict=False)) if not np.isclose(a, b, atol=1e-3) ] assert not mismatches, f"Vector values mismatch at indices: {mismatches}" diff --git a/pyaptamer/AptaNet/utils.py b/pyaptamer/AptaNet/utils.py index 761d8b59..55805ea7 100644 --- a/pyaptamer/AptaNet/utils.py +++ b/pyaptamer/AptaNet/utils.py @@ -1,5 +1,20 @@ +""" +Utility functions for amino acid sequence validation in AptaNet. + +This module provides helper functions for checking whether a string consists only of +valid amino acid single-letter codes (the 20 standard amino acids). The set AMINO_ACIDS +is used for efficient membership testing. + +Functions +--------- +is_valid_aa(seq) + Returns True if all characters in the input string are valid amino acid + codes, False otherwise. +""" + AMINO_ACIDS = set("ACDEFGHIKLMNPQRSTVWY") + def is_valid_aa(seq): """ Check if the sequence contains only valid amino acids. @@ -14,4 +29,4 @@ def is_valid_aa(seq): bool True if all characters are valid amino acids, False otherwise. """ - return all(aa in AMINO_ACIDS for aa in seq) \ No newline at end of file + return all(aa in AMINO_ACIDS for aa in seq) diff --git a/pyproject.toml b/pyproject.toml index 93089c41..f7905493 100644 --- a/pyproject.toml +++ b/pyproject.toml @@ -28,7 +28,7 @@ line-length = 88 target-version = "py310" # Match your `>=3.10` requirement # Choose what to check for -select = ["E", "F", "B", "I", "UP", "N", "C4"] +lint.select = ["E", "F", "B", "I", "UP", "N", "C4"] exclude = ["__pycache__", ".venv", "build", "dist", ".git"] From 04ab599a95464eb309e3e871a23566c022f3d21c Mon Sep 17 00:00:00 2001 From: satvshr Date: Fri, 11 Jul 2025 08:59:23 +0530 Subject: [PATCH 014/145] Made suggested changes --- pyaptamer/AptaNet/_props.py | 2375 ++++++++++++++++++------------ pyaptamer/AptaNet/pseaac.py | 87 +- pyaptamer/AptaNet/test_pseaac.py | 473 +----- pyaptamer/{AptaNet => }/utils.py | 0 4 files changed, 1462 insertions(+), 1473 deletions(-) rename pyaptamer/{AptaNet => }/utils.py (100%) diff --git a/pyaptamer/AptaNet/_props.py b/pyaptamer/AptaNet/_props.py index e2dccf63..0c750a16 100644 --- a/pyaptamer/AptaNet/_props.py +++ b/pyaptamer/AptaNet/_props.py @@ -1,991 +1,1406 @@ -""" -Amino acid physicochemical property constants for PSeAAC. +import numpy as np +import pandas as pd -This module provides hard-coded dictionaries for 21 different physicochemical -properties (P1–P21) of the 20 standard amino acids, as well as their normalized -versions (NP1–NP21). -Each Pi dictionary maps single-letter amino acid codes to a specific property -value. The properties include hydrophobicity, hydrophilicity, side-chain mass, -polarity, molecular weight, melting point, transfer free energy, buriability, -bulkiness, solvation free energy, relative mutability, residue volume, volume, -amino acid distribution, hydration number, isoelectric point, compressibility, -chromatographic index, unfolding entropy change, unfolding enthalpy change, -and unfolding Gibbs free energy change. +def aa_props(type="numpy", normalize=True): + """ + Amino acid physicochemical property matrix for PSeAAC. -Each NPi dictionary contains the z-score normalized values of the corresponding -Pi property, rounded to three decimal places, for use in feature calculations. + This function provides a 20x21 matrix of physicochemical properties for the + 20 standard amino acids. Each row corresponds to an amino acid (in the order: + A, C, D, E, F, G, H, I, K, L, M, N, P, Q, R, S, T, V, W, Y), and each column + corresponds to a property (P1–P21). The properties include hydrophobicity, + hydrophilicity, side-chain mass, polarity, molecular weight, melting point, + transfer free energy, buriability, bulkiness, + solvation free energy, relative mutability, residue volume, volume, amino acid + distribution, hydration number, isoelectric point, compressibility, chromatographic + index, unfolding entropy change, unfolding enthalpy change, and unfolding Gibbs free + energy change. -These constants are intended for internal use by the PSeAAC feature generator. -""" + References + ---------- + - Hydrophobicity values are from JACS, 1962, 84: 4240-4246. (C. Tanford) + - Hydrophilicity values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods) + - Side-chain mass for each of the 20 amino acids. + - Polarity values are from JACS, 1962, 84: 4240-4246. (C. Tanford) + - Molecular weight values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods) + - Melting point for each of the 20 amino acids. + - Transfer free energy values are from JACS, 1962, 84: 4240-4246. (C. Tanford) + - Buriability values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods) + - Bulkiness for each of the 20 amino acids. + - Solvation free energy values are from JACS, 1962, 84: 4240-4246. (C. Tanford) + - Relative mutability values are from PNAS, 1981, 78:3824-3828 + (T.P.Hopp & K.R.Woods) + - Residue volume for each of the 20 amino acids. + - Volume values are from JACS, 1962, 84: 4240-4246. (C. Tanford) + - Amino acid distribution values are from PNAS, 1981, 78:3824-3828 + (T.P.Hopp & K.R.Woods) + - Hydration number for each of the 20 amino acids. + - Isoelectric point values are from JACS, 1962, 84: 4240-4246. (C. Tanford) + - Compressibility values are from PNAS, 1981, 78:3824-3828 + (T.P.Hopp & K.R.Woods) + - Chromatographic index for each of the 20 amino acids. + - Unfolding entropy change values are from JACS, 1962, 84: 4240-4246. (C. Tanford) + - Unfolding enthalpy change values are from PNAS, 1981, 78:3824-3828 + (T.P.Hopp & K.R.Woods) + - Unfolding Gibbs free energy change for each of the 20 amino acids. -# The hydrophobicity values are from JACS, 1962, 84: 4240-4246. (C. Tanford). -P1 = { - "A": 0.62, - "C": 0.29, - "D": -0.90, - "E": -0.74, - "F": 1.19, - "G": 0.48, - "H": -0.40, - "I": 1.38, - "K": -1.50, - "L": 1.06, - "M": 0.64, - "N": -0.78, - "P": 0.12, - "Q": -0.85, - "R": -2.53, - "S": -0.18, - "T": -0.05, - "V": 1.08, - "W": 0.81, - "Y": 0.26, -} + Parameters + ---------- + type : {'numpy', 'pandas'}, default='numpy' + If 'pandas', returns a DataFrame with amino acid and property labels. + If 'numpy', returns a numpy array. + normalize : bool, default=True + If True, returns z-score normalized properties (column-wise). -# The hydrophilicity values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods). -P2 = { - "A": -0.5, - "C": -1.0, - "D": 3.0, - "E": 3.0, - "F": -2.5, - "G": 0.0, - "H": -0.5, - "I": -1.8, - "K": 3.0, - "L": -1.8, - "M": -1.3, - "N": 0.2, - "P": 0.0, - "Q": 0.2, - "R": 3.0, - "S": 0.3, - "T": -0.4, - "V": -1.5, - "W": -3.4, - "Y": -2.3, -} + Returns + ------- + props : pandas.DataFrame or numpy.ndarray + Amino acid property matrix. Rows are amino acids, columns are properties. -# The side-chain mass for each of the 20 amino acids. -P3 = { - "A": 15.0, - "C": 47.0, - "D": 59.0, - "E": 73.0, - "F": 91.0, - "G": 1.0, - "H": 82.0, - "I": 57.0, - "K": 73.0, - "L": 57.0, - "M": 75.0, - "N": 58.0, - "P": 42.0, - "Q": 72.0, - "R": 101.0, - "S": 31.0, - "T": 45.0, - "V": 43.0, - "W": 130.0, - "Y": 107.0, -} + Examples + -------- + >>> df = aa_props() + >>> arr = aa_props(type="numpy", normalize=True) + """ + aa_order = [ + "A", + "C", + "D", + "E", + "F", + "G", + "H", + "I", + "K", + "L", + "M", + "N", + "P", + "Q", + "R", + "S", + "T", + "V", + "W", + "Y", + ] + prop_names = [ + "hydrophobicity", + "hydrophilicity", + "side_chain_mass", + "polarity", + "molecular_weight", + "melting_point", + "transfer_free_energy", + "buriability", + "bulkiness", + "solvation_free_energy", + "relative_mutability", + "residue_volume", + "volume", + "aa_distribution", + "hydration_number", + "isoelectric_point", + "compressibility", + "chromatographic_index", + "unfolding_entropy_change", + "unfolding_enthalpy_change", + "unfolding_gibbs_free_energy", + ] + # 20x21 property matrix, rows = AAs, columns = P1-P21 + props = np.array( + [ + [ + 0.62, + 0.29, + -0.90, + -0.74, + 1.19, + 0.48, + -0.40, + 1.38, + -1.50, + 1.06, + 0.64, + -0.78, + 0.12, + -0.85, + -2.53, + -0.18, + -0.05, + 1.08, + 0.81, + 0.26, + ], + [ + -0.5, + -1.0, + 3.0, + 3.0, + -2.5, + 0.0, + -0.5, + -1.8, + 3.0, + -1.8, + -1.3, + 0.2, + 0.0, + 0.2, + 3.0, + 0.3, + -0.4, + -1.5, + -3.4, + -2.3, + ], + [ + 15.0, + 47.0, + 59.0, + 73.0, + 91.0, + 1.0, + 82.0, + 57.0, + 73.0, + 57.0, + 75.0, + 58.0, + 42.0, + 72.0, + 101.0, + 31.0, + 45.0, + 43.0, + 130.0, + 107.0, + ], + [ + 0.5, + 2.5, + -1.0, + 2.5, + -2.5, + 0.0, + -0.5, + 1.8, + 3.0, + -1.8, + -1.3, + 0.2, + -1.4, + 0.2, + 3.0, + 0.3, + -0.4, + -1.5, + -3.4, + -2.3, + ], + [ + 5.3, + 3.6, + 1.3, + 3.3, + 2.3, + 4.8, + 1.4, + 3.1, + 4.1, + 4.7, + 1.1, + 3.0, + 2.5, + 2.4, + 2.6, + 4.5, + 3.7, + 4.2, + 0.8, + 2.3, + ], + [ + 0.81, + 0.71, + 1.17, + 0.53, + 1.20, + 0.88, + 0.92, + 1.48, + 0.77, + 1.24, + 1.05, + 0.62, + 0.61, + 0.98, + 0.85, + 0.92, + 1.18, + 1.66, + 1.18, + 1.23, + ], + [ + 58.0, + -97.0, + 116.0, + -131.0, + 92.0, + -11.0, + -73.0, + 107.0, + -24.0, + 95.0, + 78.0, + -93.0, + -79.0, + -139.0, + -184.0, + -34.0, + -7.0, + 100.0, + 59.0, + -11.0, + ], + [ + 1.37, + 8.93, + -4.47, + 4.04, + -7.96, + 3.39, + -1.65, + -7.92, + 7.70, + -8.68, + -7.13, + 6.29, + 6.25, + 3.88, + 1.33, + 4.08, + 4.02, + -6.94, + 0.79, + -4.73, + ], + [ + 6.77, + 8.57, + 0.31, + 12.93, + 1.92, + 7.95, + 2.80, + 2.72, + 10.20, + 4.43, + 1.87, + 5.50, + 4.79, + 5.24, + 6.87, + 5.41, + 5.36, + 3.57, + 0.54, + 2.26, + ], + [ + 0.87, + 0.66, + 1.52, + 0.67, + 2.87, + 0.10, + 0.87, + 3.15, + 1.64, + 2.17, + 1.67, + 0.09, + 2.77, + 0.00, + 0.85, + 0.07, + 0.07, + 1.87, + 3.77, + 2.67, + ], + [ + 1.09, + 0.77, + 0.50, + 0.92, + 0.50, + 1.25, + 0.67, + 0.66, + 1.25, + 0.44, + 0.45, + 1.14, + 2.96, + 0.83, + 0.97, + 1.21, + 1.33, + 0.56, + 0.62, + 0.94, + ], + [ + 0.91, + 1.40, + 0.93, + 0.97, + 0.72, + 1.51, + 0.90, + 0.65, + 0.82, + 0.59, + 0.58, + 1.64, + 1.66, + 0.94, + 1.00, + 1.23, + 1.04, + 0.60, + 0.67, + 0.92, + ], + [ + 0.92, + 0.48, + 1.16, + 0.61, + 1.25, + 0.61, + 0.93, + 1.81, + 0.70, + 1.30, + 1.19, + 0.60, + 0.40, + 0.95, + 0.93, + 0.82, + 1.12, + 1.81, + 1.54, + 1.53, + ], + [ + 0.96, + 0.90, + 1.13, + 0.33, + 1.37, + 0.90, + 0.87, + 1.54, + 0.81, + 1.26, + 1.29, + 0.72, + 0.75, + 1.18, + 0.67, + 0.77, + 1.23, + 1.41, + 1.13, + 1.07, + ], + [ + 0.90, + 0.47, + 1.24, + 0.62, + 1.23, + 0.56, + 1.12, + 1.54, + 0.74, + 1.26, + 1.09, + 0.62, + 0.42, + 1.18, + 1.02, + 0.87, + 1.30, + 1.53, + 1.75, + 1.68, + ], + [ + 6.00, + 5.05, + 2.77, + 5.22, + 5.48, + 5.97, + 7.59, + 6.02, + 9.74, + 5.98, + 5.74, + 5.41, + 6.30, + 5.65, + 10.76, + 5.68, + 5.66, + 5.96, + 5.89, + 5.66, + ], + [ + -25.5, + -32.82, + -33.12, + -36.17, + -34.54, + -27.0, + -31.84, + -31.78, + -32.4, + -31.78, + -31.18, + -30.9, + -23.25, + -32.6, + -26.62, + -29.88, + -31.23, + -30.62, + -30.24, + -35.01, + ], + [ + 9.9, + 2.8, + 2.8, + 3.2, + 18.8, + 5.6, + 8.2, + 17.1, + 3.5, + 17.6, + 14.7, + 5.4, + 14.8, + 9.0, + 4.6, + 6.9, + 9.5, + 14.3, + 17.0, + 15.0, + ], + [ + 0.54, + -4.14, + -0.26, + -0.19, + -4.66, + -0.31, + -0.23, + -0.27, + 1.13, + -0.24, + -2.36, + 1.74, + -0.08, + 1.53, + 3.69, + -0.24, + -0.28, + -0.36, + -2.69, + -2.82, + ], + [ + 0.51, + 5.21, + 0.18, + 0.05, + 6.82, + -0.23, + 0.79, + 0.19, + -1.45, + 0.17, + 2.89, + -2.03, + 0.02, + -1.76, + -4.40, + -0.16, + 0.04, + 0.30, + 4.47, + 3.73, + ], + [ + -0.02, + 1.08, + -0.08, + -0.13, + 2.16, + 0.09, + 0.56, + -0.08, + -0.32, + -0.08, + 0.53, + -0.30, + -0.06, + -0.23, + -0.71, + -0.40, + -0.24, + -0.06, + 1.78, + -0.91, + ], + ] + ).T # shape (20, 21) -# The Polarity values are from JACS, 1962, 84: 4240-4246. (C. Tanford). -P4 = { - "A": 0.5, - "C": 2.5, - "D": -1, - "E": 2.5, - "F": -2.5, - "G": 0, - "H": -0.5, - "I": 1.8, - "K": 3, - "L": -1.8, - "M": -1.3, - "N": 0.2, - "P": -1.4, - "Q": 0.2, - "R": 3, - "S": 0.3, - "T": -0.4, - "V": -1.5, - "W": -3.4, - "Y": -2.3, -} + if normalize: + props = np.array( + [ + [ + 0.636, + 0.298, + -0.924, + -0.759, + 1.221, + 0.493, + -0.41, + 1.416, + -1.539, + 1.088, + 0.657, + -0.8, + 0.123, + -0.872, + -2.596, + -0.185, + -0.051, + 1.108, + 0.831, + 0.267, + ], + [ + -0.152, + -0.418, + 1.713, + 1.713, + -1.218, + 0.115, + -0.152, + -0.845, + 1.713, + -0.845, + -0.578, + 0.221, + 0.115, + 0.221, + 1.713, + 0.274, + -0.099, + -0.685, + -1.697, + -1.111, + ], + [ + -1.592, + -0.53, + -0.131, + 0.334, + 0.931, + -2.057, + 0.632, + -0.198, + 0.334, + -0.198, + 0.4, + -0.164, + -0.696, + 0.3, + 1.263, + -1.061, + -0.596, + -0.662, + 2.226, + 1.462, + ], + [ + 0.329, + 1.417, + -0.487, + 1.417, + -1.303, + 0.057, + -0.215, + 1.036, + 1.689, + -0.922, + -0.65, + 0.166, + -0.704, + 0.166, + 1.689, + 0.22, + -0.16, + -0.759, + -1.792, + -1.194, + ], + [ + 1.755, + 0.429, + -1.365, + 0.195, + -0.585, + 1.365, + -1.287, + 0.039, + 0.819, + 1.287, + -1.521, + -0.039, + -0.429, + -0.507, + -0.351, + 1.131, + 0.507, + 0.897, + -1.755, + -0.585, + ], + [ + -0.659, + -1.007, + 0.593, + -1.633, + 0.697, + -0.416, + -0.277, + 1.671, + -0.798, + 0.836, + 0.176, + -1.32, + -1.355, + -0.068, + -0.52, + -0.277, + 0.628, + 2.297, + 0.628, + 0.802, + ], + [ + 0.735, + -0.968, + 1.372, + -1.341, + 1.108, + -0.023, + -0.704, + 1.273, + -0.166, + 1.141, + 0.955, + -0.924, + -0.77, + -1.429, + -1.924, + -0.276, + 0.021, + 1.196, + 0.746, + -0.023, + ], + [ + 0.219, + 1.552, + -0.811, + 0.69, + -1.427, + 0.575, + -0.314, + -1.42, + 1.335, + -1.554, + -1.281, + 1.087, + 1.08, + 0.662, + 0.212, + 0.697, + 0.686, + -1.247, + 0.117, + -0.857, + ], + [ + 0.56, + 1.13, + -1.484, + 2.509, + -0.975, + 0.933, + -0.696, + -0.722, + 1.645, + -0.181, + -0.991, + 0.158, + -0.067, + 0.076, + 0.592, + 0.13, + 0.114, + -0.453, + -1.411, + -0.867, + ], + [ + -0.479, + -0.663, + 0.09, + -0.654, + 1.271, + -1.153, + -0.479, + 1.516, + 0.195, + 0.658, + 0.221, + -1.161, + 1.183, + -1.24, + -0.496, + -1.179, + -1.179, + 0.396, + 2.058, + 1.096, + ], + [ + 0.253, + -0.338, + -0.836, + -0.061, + -0.836, + 0.548, + -0.522, + -0.541, + 0.548, + -0.947, + -0.928, + 0.345, + 3.703, + -0.227, + 0.031, + 0.474, + 0.696, + -0.725, + -0.614, + -0.024, + ], + [ + -0.223, + 1.256, + -0.163, + -0.042, + -0.797, + 1.588, + -0.254, + -1.008, + -0.495, + -1.189, + -1.219, + 1.98, + 2.04, + -0.133, + 0.048, + 0.743, + 0.169, + -1.159, + -0.948, + -0.193, + ], + [ + -0.277, + -1.356, + 0.311, + -1.037, + 0.532, + -1.037, + -0.253, + 1.905, + -0.816, + 0.655, + 0.385, + -1.062, + -1.552, + -0.203, + -0.253, + -0.522, + 0.213, + 1.905, + 1.243, + 1.219, + ], + [ + -0.187, + -0.393, + 0.397, + -2.352, + 1.221, + -0.393, + -0.496, + 1.805, + -0.703, + 0.843, + 0.947, + -1.012, + -0.909, + 0.569, + -1.184, + -0.84, + 0.74, + 1.359, + 0.397, + 0.191, + ], + [ + -0.402, + -1.503, + 0.469, + -1.119, + 0.443, + -1.273, + 0.161, + 1.237, + -0.812, + 0.52, + 0.085, + -1.119, + -1.631, + 0.315, + -0.095, + -0.479, + 0.622, + 1.211, + 1.775, + 1.595, + ], + [ + -0.078, + -0.667, + -2.081, + -0.562, + -0.401, + -0.097, + 0.907, + -0.066, + 2.24, + -0.091, + -0.24, + -0.444, + 0.108, + -0.295, + 2.872, + -0.277, + -0.289, + -0.103, + -0.147, + -0.289, + ], + [ + 1.728, + -0.604, + -0.7, + -1.671, + -1.152, + 1.25, + -0.292, + -0.273, + -0.47, + -0.273, + -0.082, + 0.008, + 2.445, + -0.534, + 1.371, + 0.333, + -0.097, + 0.097, + 0.218, + -1.302, + ], + [ + -0.025, + -1.322, + -1.322, + -1.249, + 1.601, + -0.81, + -0.335, + 1.291, + -1.194, + 1.382, + 0.852, + -0.847, + 0.871, + -0.189, + -0.993, + -0.573, + -0.098, + 0.779, + 1.273, + 0.907, + ], + [ + 0.549, + -1.863, + 0.137, + 0.173, + -2.131, + 0.111, + 0.152, + 0.131, + 0.853, + 0.147, + -0.946, + 1.167, + 0.229, + 1.059, + 2.172, + 0.147, + 0.126, + 0.085, + -1.116, + -1.183, + ], + [ + -0.099, + 1.717, + -0.227, + -0.277, + 2.339, + -0.385, + 0.009, + -0.223, + -0.857, + -0.231, + 0.82, + -1.081, + -0.289, + -0.976, + -1.996, + -0.358, + -0.281, + -0.18, + 1.431, + 1.145, + ], + [ + -0.2, + 1.276, + -0.28, + -0.348, + 2.725, + -0.052, + 0.578, + -0.28, + -0.602, + -0.28, + 0.538, + -0.576, + -0.254, + -0.482, + -1.126, + -0.71, + -0.495, + -0.254, + 2.215, + -1.394, + ], + ] + ).T # shape (20, 21) -# The Molecular weight values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods). -P5 = { - "A": 5.3, - "C": 3.6, - "D": 1.3, - "E": 3.3, - "F": 2.3, - "G": 4.8, - "H": 1.4, - "I": 3.1, - "K": 4.1, - "L": 4.7, - "M": 1.1, - "N": 3, - "P": 2.5, - "Q": 2.4, - "R": 2.6, - "S": 4.5, - "T": 3.7, - "V": 4.2, - "W": 0.8, - "Y": 2.3, -} + if type == "pandas": + return pd.DataFrame(props, index=aa_order, columns=prop_names) + elif type == "numpy": + return props + else: + raise ValueError("type must be 'numpy' or 'pandas'") -# The Meling point for each of the 20 amino acids. -P6 = { - "A": 0.81, - "C": 0.71, - "D": 1.17, - "E": 0.53, - "F": 1.2, - "G": 0.88, - "H": 0.92, - "I": 1.48, - "K": 0.77, - "L": 1.24, - "M": 1.05, - "N": 0.62, - "P": 0.61, - "Q": 0.98, - "R": 0.85, - "S": 0.92, - "T": 1.18, - "V": 1.66, - "W": 1.18, - "Y": 1.23, -} -# The Transfer_free_energy values are from JACS, 1962, 84: 4240-4246. (C. Tanford). -P7 = { - "A": 58, - "C": -97, - "D": 116, - "E": -131, - "F": 92, - "G": -11, - "H": -73, - "I": 107, - "K": -24, - "L": 95, - "M": 78, - "N": -93, - "P": -79, - "Q": -139, - "R": -184, - "S": -34, - "T": -7, - "V": 100, - "W": 59, - "Y": -11, -} - -# The Buriability values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods). -P8 = { - "A": 1.37, - "C": 8.93, - "D": -4.47, - "E": 4.04, - "F": -7.96, - "G": 3.39, - "H": -1.65, - "I": -7.92, - "K": 7.7, - "L": -8.68, - "M": -7.13, - "N": 6.29, - "P": 6.25, - "Q": 3.88, - "R": 1.33, - "S": 4.08, - "T": 4.02, - "V": -6.94, - "W": 0.79, - "Y": -4.73, -} - -# The Bulkiness for each of the 20 amino acids. -P9 = { - "A": 6.77, - "C": 8.57, - "D": 0.31, - "E": 12.93, - "F": 1.92, - "G": 7.95, - "H": 2.8, - "I": 2.72, - "K": 10.2, - "L": 4.43, - "M": 1.87, - "N": 5.5, - "P": 4.79, - "Q": 5.24, - "R": 6.87, - "S": 5.41, - "T": 5.36, - "V": 3.57, - "W": 0.54, - "Y": 2.26, -} - -# The Solvation_free_energy values are from JACS, 1962, 84: 4240-4246. (C. Tanford). -P10 = { - "A": 0.87, - "C": 0.66, - "D": 1.52, - "E": 0.67, - "F": 2.87, - "G": 0.1, - "H": 0.87, - "I": 3.15, - "K": 1.64, - "L": 2.17, - "M": 1.67, - "N": 0.09, - "P": 2.77, - "Q": 0, - "R": 0.85, - "S": 0.07, - "T": 0.07, - "V": 1.87, - "W": 3.77, - "Y": 2.67, -} - -# The Relative_mutability values are from PNAS, 1981, 78:3824-3828 -# (T.P.Hopp & K.R.Woods). -P11 = { - "A": 1.09, - "C": 0.77, - "D": 0.5, - "E": 0.92, - "F": 0.5, - "G": 1.25, - "H": 0.67, - "I": 0.66, - "K": 1.25, - "L": 0.44, - "M": 0.45, - "N": 1.14, - "P": 2.96, - "Q": 0.83, - "R": 0.97, - "S": 1.21, - "T": 1.33, - "V": 0.56, - "W": 0.62, - "Y": 0.94, -} - -# The Residue_volume for each of the 20 amino acids. -P12 = { - "A": 0.91, - "C": 1.4, - "D": 0.93, - "E": 0.97, - "F": 0.72, - "G": 1.51, - "H": 0.9, - "I": 0.65, - "K": 0.82, - "L": 0.59, - "M": 0.58, - "N": 1.64, - "P": 1.66, - "Q": 0.94, - "R": 1, - "S": 1.23, - "T": 1.04, - "V": 0.6, - "W": 0.67, - "Y": 0.92, -} - -# The volume values are from JACS, 1962, 84: 4240-4246. (C. Tanford). -P13 = { - "A": 0.92, - "C": 0.48, - "D": 1.16, - "E": 0.61, - "F": 1.25, - "G": 0.61, - "H": 0.93, - "I": 1.81, - "K": 0.7, - "L": 1.3, - "M": 1.19, - "N": 0.6, - "P": 0.4, - "Q": 0.95, - "R": 0.93, - "S": 0.82, - "T": 1.12, - "V": 1.81, - "W": 1.54, - "Y": 1.53, -} - -# The Amino_acid_distribution values are from PNAS, 1981, 78:3824-3828 -# (T.P.Hopp & K.R.Woods). -P14 = { - "A": 0.96, - "C": 0.9, - "D": 1.13, - "E": 0.33, - "F": 1.37, - "G": 0.9, - "H": 0.87, - "I": 1.54, - "K": 0.81, - "L": 1.26, - "M": 1.29, - "N": 0.72, - "P": 0.75, - "Q": 1.18, - "R": 0.67, - "S": 0.77, - "T": 1.23, - "V": 1.41, - "W": 1.13, - "Y": 1.07, -} - -# The Hydration_number for each of the 20 amino acids. -P15 = { - "A": 0.9, - "C": 0.47, - "D": 1.24, - "E": 0.62, - "F": 1.23, - "G": 0.56, - "H": 1.12, - "I": 1.54, - "K": 0.74, - "L": 1.26, - "M": 1.09, - "N": 0.62, - "P": 0.42, - "Q": 1.18, - "R": 1.02, - "S": 0.87, - "T": 1.3, - "V": 1.53, - "W": 1.75, - "Y": 1.68, -} - -# The Isoelectric_point values are from JACS, 1962, 84: 4240-4246. (C. Tanford). -P16 = { - "A": 6, - "C": 5.05, - "D": 2.77, - "E": 5.22, - "F": 5.48, - "G": 5.97, - "H": 7.59, - "I": 6.02, - "K": 9.74, - "L": 5.98, - "M": 5.74, - "N": 5.41, - "P": 6.3, - "Q": 5.65, - "R": 10.76, - "S": 5.68, - "T": 5.66, - "V": 5.96, - "W": 5.89, - "Y": 5.66, -} - -# The Compressibility values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods). -P17 = { - "A": -25.5, - "C": -32.82, - "D": -33.12, - "E": -36.17, - "F": -34.54, - "G": -27, - "H": -31.84, - "I": -31.78, - "K": -32.4, - "L": -31.78, - "M": -31.18, - "N": -30.9, - "P": -23.25, - "Q": -32.6, - "R": -26.62, - "S": -29.88, - "T": -31.23, - "V": -30.62, - "W": -30.24, - "Y": -35.01, -} - -# The Chromatographic_index for each of the 20 amino acids. -P18 = { - "A": 9.9, - "C": 2.8, - "D": 2.8, - "E": 3.2, - "F": 18.8, - "G": 5.6, - "H": 8.2, - "I": 17.1, - "K": 3.5, - "L": 17.6, - "M": 14.7, - "N": 5.4, - "P": 14.8, - "Q": 9, - "R": 4.6, - "S": 6.9, - "T": 9.5, - "V": 14.3, - "W": 17, - "Y": 15, -} - -# The Unfolding_entropy_change values are from JACS, 1962, 84: 4240-4246. (C. Tanford). -P19 = { - "A": 0.54, - "C": -4.14, - "D": -0.26, - "E": -0.19, - "F": -4.66, - "G": -0.31, - "H": -0.23, - "I": -0.27, - "K": 1.13, - "L": -0.24, - "M": -2.36, - "N": 1.74, - "P": -0.08, - "Q": 1.53, - "R": 3.69, - "S": -0.24, - "T": -0.28, - "V": -0.36, - "W": -2.69, - "Y": -2.82, -} - -# The Unfolding_entalpy_change values are from PNAS, 1981, 78:3824-3828 -# (T.P.Hopp & K.R.Woods). -P20 = { - "A": 0.51, - "C": 5.21, - "D": 0.18, - "E": 0.05, - "F": 6.82, - "G": -0.23, - "H": 0.79, - "I": 0.19, - "K": -1.45, - "L": 0.17, - "M": 2.89, - "N": -2.03, - "P": 0.02, - "Q": -1.76, - "R": -4.4, - "S": -0.16, - "T": 0.04, - "V": 0.3, - "W": 4.47, - "Y": 3.73, -} - -# The Unfolding_Gibbs_free_energy_change for each of the 20 amino acids. -P21 = { - "A": -0.02, - "C": 1.08, - "D": -0.08, - "E": -0.13, - "F": 2.16, - "G": 0.09, - "H": 0.56, - "I": -0.08, - "K": -0.32, - "L": -0.08, - "M": 0.53, - "N": -0.3, - "P": -0.06, - "Q": -0.23, - "R": -0.71, - "S": -0.4, - "T": -0.24, - "V": -0.06, - "W": 1.78, - "Y": -0.91, -} - -# Normalized properties upto 3 decimal places -NP1 = { - "A": 0.636, - "C": 0.298, - "D": -0.924, - "E": -0.759, - "F": 1.221, - "G": 0.493, - "H": -0.41, - "I": 1.416, - "K": -1.539, - "L": 1.088, - "M": 0.657, - "N": -0.8, - "P": 0.123, - "Q": -0.872, - "R": -2.596, - "S": -0.185, - "T": -0.051, - "V": 1.108, - "W": 0.831, - "Y": 0.267, -} -NP2 = { - "A": -0.152, - "C": -0.418, - "D": 1.713, - "E": 1.713, - "F": -1.218, - "G": 0.115, - "H": -0.152, - "I": -0.845, - "K": 1.713, - "L": -0.845, - "M": -0.578, - "N": 0.221, - "P": 0.115, - "Q": 0.221, - "R": 1.713, - "S": 0.274, - "T": -0.099, - "V": -0.685, - "W": -1.697, - "Y": -1.111, -} -NP3 = { - "A": -1.592, - "C": -0.53, - "D": -0.131, - "E": 0.334, - "F": 0.931, - "G": -2.057, - "H": 0.632, - "I": -0.198, - "K": 0.334, - "L": -0.198, - "M": 0.4, - "N": -0.164, - "P": -0.696, - "Q": 0.3, - "R": 1.263, - "S": -1.061, - "T": -0.596, - "V": -0.662, - "W": 2.226, - "Y": 1.462, -} -NP4 = { - "A": 0.329, - "C": 1.417, - "D": -0.487, - "E": 1.417, - "F": -1.303, - "G": 0.057, - "H": -0.215, - "I": 1.036, - "K": 1.689, - "L": -0.922, - "M": -0.65, - "N": 0.166, - "P": -0.704, - "Q": 0.166, - "R": 1.689, - "S": 0.22, - "T": -0.16, - "V": -0.759, - "W": -1.792, - "Y": -1.194, -} -NP5 = { - "A": 1.755, - "C": 0.429, - "D": -1.365, - "E": 0.195, - "F": -0.585, - "G": 1.365, - "H": -1.287, - "I": 0.039, - "K": 0.819, - "L": 1.287, - "M": -1.521, - "N": -0.039, - "P": -0.429, - "Q": -0.507, - "R": -0.351, - "S": 1.131, - "T": 0.507, - "V": 0.897, - "W": -1.755, - "Y": -0.585, -} -NP6 = { - "A": -0.659, - "C": -1.007, - "D": 0.593, - "E": -1.633, - "F": 0.697, - "G": -0.416, - "H": -0.277, - "I": 1.671, - "K": -0.798, - "L": 0.836, - "M": 0.176, - "N": -1.32, - "P": -1.355, - "Q": -0.068, - "R": -0.52, - "S": -0.277, - "T": 0.628, - "V": 2.297, - "W": 0.628, - "Y": 0.802, -} -NP7 = { - "A": 0.735, - "C": -0.968, - "D": 1.372, - "E": -1.341, - "F": 1.108, - "G": -0.023, - "H": -0.704, - "I": 1.273, - "K": -0.166, - "L": 1.141, - "M": 0.955, - "N": -0.924, - "P": -0.77, - "Q": -1.429, - "R": -1.924, - "S": -0.276, - "T": 0.021, - "V": 1.196, - "W": 0.746, - "Y": -0.023, -} -NP8 = { - "A": 0.219, - "C": 1.552, - "D": -0.811, - "E": 0.69, - "F": -1.427, - "G": 0.575, - "H": -0.314, - "I": -1.42, - "K": 1.335, - "L": -1.554, - "M": -1.281, - "N": 1.087, - "P": 1.08, - "Q": 0.662, - "R": 0.212, - "S": 0.697, - "T": 0.686, - "V": -1.247, - "W": 0.117, - "Y": -0.857, -} -NP9 = { - "A": 0.56, - "C": 1.13, - "D": -1.484, - "E": 2.509, - "F": -0.975, - "G": 0.933, - "H": -0.696, - "I": -0.722, - "K": 1.645, - "L": -0.181, - "M": -0.991, - "N": 0.158, - "P": -0.067, - "Q": 0.076, - "R": 0.592, - "S": 0.13, - "T": 0.114, - "V": -0.453, - "W": -1.411, - "Y": -0.867, -} -NP10 = { - "A": -0.479, - "C": -0.663, - "D": 0.09, - "E": -0.654, - "F": 1.271, - "G": -1.153, - "H": -0.479, - "I": 1.516, - "K": 0.195, - "L": 0.658, - "M": 0.221, - "N": -1.161, - "P": 1.183, - "Q": -1.24, - "R": -0.496, - "S": -1.179, - "T": -1.179, - "V": 0.396, - "W": 2.058, - "Y": 1.096, -} -NP11 = { - "A": 0.253, - "C": -0.338, - "D": -0.836, - "E": -0.061, - "F": -0.836, - "G": 0.548, - "H": -0.522, - "I": -0.541, - "K": 0.548, - "L": -0.947, - "M": -0.928, - "N": 0.345, - "P": 3.703, - "Q": -0.227, - "R": 0.031, - "S": 0.474, - "T": 0.696, - "V": -0.725, - "W": -0.614, - "Y": -0.024, -} -NP12 = { - "A": -0.223, - "C": 1.256, - "D": -0.163, - "E": -0.042, - "F": -0.797, - "G": 1.588, - "H": -0.254, - "I": -1.008, - "K": -0.495, - "L": -1.189, - "M": -1.219, - "N": 1.98, - "P": 2.04, - "Q": -0.133, - "R": 0.048, - "S": 0.743, - "T": 0.169, - "V": -1.159, - "W": -0.948, - "Y": -0.193, -} -NP13 = { - "A": -0.277, - "C": -1.356, - "D": 0.311, - "E": -1.037, - "F": 0.532, - "G": -1.037, - "H": -0.253, - "I": 1.905, - "K": -0.816, - "L": 0.655, - "M": 0.385, - "N": -1.062, - "P": -1.552, - "Q": -0.203, - "R": -0.253, - "S": -0.522, - "T": 0.213, - "V": 1.905, - "W": 1.243, - "Y": 1.219, -} -NP14 = { - "A": -0.187, - "C": -0.393, - "D": 0.397, - "E": -2.352, - "F": 1.221, - "G": -0.393, - "H": -0.496, - "I": 1.805, - "K": -0.703, - "L": 0.843, - "M": 0.947, - "N": -1.012, - "P": -0.909, - "Q": 0.569, - "R": -1.184, - "S": -0.84, - "T": 0.74, - "V": 1.359, - "W": 0.397, - "Y": 0.191, -} -NP15 = { - "A": -0.402, - "C": -1.503, - "D": 0.469, - "E": -1.119, - "F": 0.443, - "G": -1.273, - "H": 0.161, - "I": 1.237, - "K": -0.812, - "L": 0.52, - "M": 0.085, - "N": -1.119, - "P": -1.631, - "Q": 0.315, - "R": -0.095, - "S": -0.479, - "T": 0.622, - "V": 1.211, - "W": 1.775, - "Y": 1.595, -} -NP16 = { - "A": -0.078, - "C": -0.667, - "D": -2.081, - "E": -0.562, - "F": -0.401, - "G": -0.097, - "H": 0.907, - "I": -0.066, - "K": 2.24, - "L": -0.091, - "M": -0.24, - "N": -0.444, - "P": 0.108, - "Q": -0.295, - "R": 2.872, - "S": -0.277, - "T": -0.289, - "V": -0.103, - "W": -0.147, - "Y": -0.289, -} -NP17 = { - "A": 1.728, - "C": -0.604, - "D": -0.7, - "E": -1.671, - "F": -1.152, - "G": 1.25, - "H": -0.292, - "I": -0.273, - "K": -0.47, - "L": -0.273, - "M": -0.082, - "N": 0.008, - "P": 2.445, - "Q": -0.534, - "R": 1.371, - "S": 0.333, - "T": -0.097, - "V": 0.097, - "W": 0.218, - "Y": -1.302, -} -NP18 = { - "A": -0.025, - "C": -1.322, - "D": -1.322, - "E": -1.249, - "F": 1.601, - "G": -0.81, - "H": -0.335, - "I": 1.291, - "K": -1.194, - "L": 1.382, - "M": 0.852, - "N": -0.847, - "P": 0.871, - "Q": -0.189, - "R": -0.993, - "S": -0.573, - "T": -0.098, - "V": 0.779, - "W": 1.273, - "Y": 0.907, -} -NP19 = { - "A": 0.549, - "C": -1.863, - "D": 0.137, - "E": 0.173, - "F": -2.131, - "G": 0.111, - "H": 0.152, - "I": 0.131, - "K": 0.853, - "L": 0.147, - "M": -0.946, - "N": 1.167, - "P": 0.229, - "Q": 1.059, - "R": 2.172, - "S": 0.147, - "T": 0.126, - "V": 0.085, - "W": -1.116, - "Y": -1.183, -} -NP20 = { - "A": -0.099, - "C": 1.717, - "D": -0.227, - "E": -0.277, - "F": 2.339, - "G": -0.385, - "H": 0.009, - "I": -0.223, - "K": -0.857, - "L": -0.231, - "M": 0.82, - "N": -1.081, - "P": -0.289, - "Q": -0.976, - "R": -1.996, - "S": -0.358, - "T": -0.281, - "V": -0.18, - "W": 1.431, - "Y": 1.145, -} -NP21 = { - "A": -0.2, - "C": 1.276, - "D": -0.28, - "E": -0.348, - "F": 2.725, - "G": -0.052, - "H": 0.578, - "I": -0.28, - "K": -0.602, - "L": -0.28, - "M": 0.538, - "N": -0.576, - "P": -0.254, - "Q": -0.482, - "R": -1.126, - "S": -0.71, - "T": -0.495, - "V": -0.254, - "W": 2.215, - "Y": -1.394, -} +solution = [ + 0.012, + 0.012, + 0.012, + 0.0, + 0.025, + 0.0, + 0.0, + 0.074, + 0.05, + 0.025, + 0.025, + 0.025, + 0.025, + 0.037, + 0.087, + 0.0, + 0.0, + 0.0, + 0.0, + 0.0, + 0.008, + 0.01, + 0.005, + 0.007, + 0.014, + 0.012, + 0.002, + 0.006, + 0.016, + 0.013, + 0.007, + 0.007, + 0.005, + 0.005, + 0.007, + 0.006, + 0.003, + 0.005, + 0.01, + 0.013, + 0.028, + 0.048, + 0.053, + 0.069, + 0.055, + 0.029, + 0.034, + 0.023, + 0.074, + 0.177, + 0.016, + 0.016, + 0.016, + 0.0, + 0.031, + 0.0, + 0.0, + 0.094, + 0.063, + 0.031, + 0.031, + 0.031, + 0.031, + 0.047, + 0.11, + 0.0, + 0.0, + 0.0, + 0.0, + 0.0, + 0.007, + 0.012, + 0.017, + 0.012, + 0.005, + 0.009, + 0.017, + 0.013, + 0.007, + 0.013, + 0.01, + 0.01, + 0.022, + 0.017, + 0.009, + 0.013, + 0.013, + 0.012, + 0.012, + 0.019, + 0.018, + 0.02, + 0.022, + 0.022, + 0.038, + 0.049, + 0.057, + 0.073, + 0.066, + 0.074, + 0.012, + 0.012, + 0.012, + 0.0, + 0.025, + 0.0, + 0.0, + 0.074, + 0.05, + 0.025, + 0.025, + 0.025, + 0.025, + 0.037, + 0.087, + 0.0, + 0.0, + 0.0, + 0.0, + 0.0, + 0.009, + 0.01, + 0.016, + 0.01, + 0.002, + 0.01, + 0.018, + 0.011, + 0.003, + 0.011, + 0.011, + 0.012, + 0.02, + 0.011, + 0.01, + 0.011, + 0.014, + 0.015, + 0.017, + 0.022, + 0.025, + 0.03, + 0.033, + 0.015, + 0.039, + 0.04, + 0.047, + 0.094, + 0.074, + 0.108, + 0.019, + 0.019, + 0.019, + 0.0, + 0.039, + 0.0, + 0.0, + 0.117, + 0.078, + 0.039, + 0.039, + 0.039, + 0.039, + 0.058, + 0.136, + 0.0, + 0.0, + 0.0, + 0.0, + 0.0, + 0.004, + 0.007, + 0.01, + 0.008, + 0.006, + 0.01, + 0.013, + 0.009, + 0.005, + 0.009, + 0.011, + 0.011, + 0.017, + 0.012, + 0.036, + 0.06, + 0.051, + 0.031, + 0.007, + 0.006, + 0.006, + 0.005, + 0.006, + 0.01, + 0.031, + 0.05, + 0.058, + 0.063, + 0.039, + 0.019, + 0.015, + 0.015, + 0.015, + 0.0, + 0.031, + 0.0, + 0.0, + 0.092, + 0.061, + 0.031, + 0.031, + 0.031, + 0.031, + 0.046, + 0.107, + 0.0, + 0.0, + 0.0, + 0.0, + 0.0, + 0.005, + 0.006, + 0.009, + 0.004, + 0.004, + 0.016, + 0.023, + 0.01, + 0.001, + 0.007, + 0.009, + 0.008, + 0.012, + 0.007, + 0.01, + 0.011, + 0.004, + 0.01, + 0.008, + 0.012, + 0.01, + 0.011, + 0.012, + 0.017, + 0.056, + 0.086, + 0.101, + 0.115, + 0.07, + 0.041, + 0.009, + 0.009, + 0.009, + 0.0, + 0.018, + 0.0, + 0.0, + 0.053, + 0.035, + 0.018, + 0.018, + 0.018, + 0.018, + 0.027, + 0.062, + 0.0, + 0.0, + 0.0, + 0.0, + 0.0, + 0.006, + 0.009, + 0.011, + 0.012, + 0.01, + 0.01, + 0.011, + 0.012, + 0.012, + 0.012, + 0.009, + 0.008, + 0.006, + 0.004, + 0.012, + 0.02, + 0.011, + 0.004, + 0.007, + 0.024, + 0.037, + 0.044, + 0.049, + 0.037, + 0.031, + 0.03, + 0.036, + 0.074, + 0.113, + 0.163, + 0.011, + 0.011, + 0.011, + 0.0, + 0.021, + 0.0, + 0.0, + 0.064, + 0.043, + 0.021, + 0.021, + 0.021, + 0.021, + 0.032, + 0.075, + 0.0, + 0.0, + 0.0, + 0.0, + 0.0, + 0.014, + 0.008, + 0.009, + 0.015, + 0.007, + 0.004, + 0.005, + 0.008, + 0.008, + 0.005, + 0.007, + 0.003, + 0.004, + 0.015, + 0.013, + 0.008, + 0.008, + 0.015, + 0.016, + 0.023, + 0.04, + 0.05, + 0.054, + 0.051, + 0.023, + 0.016, + 0.018, + 0.039, + 0.118, + 0.182, +] diff --git a/pyaptamer/AptaNet/pseaac.py b/pyaptamer/AptaNet/pseaac.py index ede79c61..5e2ec3a0 100644 --- a/pyaptamer/AptaNet/pseaac.py +++ b/pyaptamer/AptaNet/pseaac.py @@ -1,28 +1,7 @@ import numpy as np -from _props import ( - NP1, - NP2, - NP3, - NP4, - NP5, - NP6, - NP7, - NP8, - NP9, - NP10, - NP11, - NP12, - NP13, - NP14, - NP15, - NP16, - NP17, - NP18, - NP19, - NP20, - NP21, -) -from utils import is_valid_aa +from _props import aa_props + +from pyaptamer.utils import is_valid_aa class PSeAAC: @@ -53,17 +32,40 @@ def __init__(self): """ Initialize PSeAAC with a protein sequence. """ - self.amino_acid = set("ACDEFGHIKLMNPQRSTVWY") + self.amino_acid = [ + "A", + "C", + "D", + "E", + "F", + "G", + "H", + "I", + "K", + "L", + "M", + "N", + "P", + "Q", + "R", + "S", + "T", + "V", + "W", + "Y", + ] - # Define 7 selected groups of 3 properties each + # Load normalized property matrix (20x21, rows=AA, cols=NP1-NP21) + self.np_matrix = aa_props(type="numpy", normalize=True) + # Each prop_group is a tuple of 3 columns (property indices) self.prop_groups = [ - (NP1, NP2, NP3), - (NP4, NP5, NP6), - (NP7, NP8, NP9), - (NP10, NP11, NP12), - (NP13, NP14, NP15), - (NP16, NP17, NP18), - (NP19, NP20, NP21), + (0, 1, 2), + (3, 4, 5), + (6, 7, 8), + (9, 10, 11), + (12, 13, 14), + (15, 16, 17), + (18, 19, 20), ] # Function to average the amino acid composition @@ -99,15 +101,20 @@ def _theta_rirj(self, ri, rj, prop_group): First amino acid. rj : str Second amino acid. - prop_group : tuple of dict - Tuple of property dictionaries. + prop_group : tuple of int + Tuple of property indices. Returns ------- float Theta value. """ - diffs = np.array([prop[rj] - prop[ri] for prop in prop_group], dtype=float) + idx_ri = self.amino_acid.index(ri) + idx_rj = self.amino_acid.index(rj) + diffs = ( + self.np_matrix[idx_rj, list(prop_group)] + - self.np_matrix[idx_ri, list(prop_group)] + ) return np.mean(diffs**2) def _sum_theta_val(self, seq, seq_len, lambda_val, n, prop_group): @@ -124,8 +131,8 @@ def _sum_theta_val(self, seq, seq_len, lambda_val, n, prop_group): Lambda parameter. n : int Offset for theta calculation. - prop_group : tuple of dict - Tuple of property dictionaries. + prop_group : tuple of int + Tuple of property indices. Returns ------- @@ -133,7 +140,7 @@ def _sum_theta_val(self, seq, seq_len, lambda_val, n, prop_group): Average theta value. """ return sum( - self._theta_RiRj(seq[i], seq[i + n], prop_group) + self._theta_rirj(seq[i], seq[i + n], prop_group) for i in range(seq_len - lambda_val) ) / (seq_len - n) @@ -144,7 +151,7 @@ def transform(self, protein_sequence): if not is_valid_aa(protein_sequence): raise ValueError( "Invalid amino acid found in protein_sequence. Only " - f"{''.join(sorted(self.amino_acid))} are allowed." + f"{''.join(self.amino_acid)} are allowed." ) lambda_val = 30 diff --git a/pyaptamer/AptaNet/test_pseaac.py b/pyaptamer/AptaNet/test_pseaac.py index f6bb277b..20415ec1 100644 --- a/pyaptamer/AptaNet/test_pseaac.py +++ b/pyaptamer/AptaNet/test_pseaac.py @@ -1,49 +1,6 @@ import numpy as np import pytest -from _props import ( - NP1, - NP2, - NP3, - NP4, - NP5, - NP6, - NP7, - NP8, - NP9, - NP10, - NP11, - NP12, - NP13, - NP14, - NP15, - NP16, - NP17, - NP18, - NP19, - NP20, - NP21, - P1, - P2, - P3, - P4, - P5, - P6, - P7, - P8, - P9, - P10, - P11, - P12, - P13, - P14, - P15, - P16, - P17, - P18, - P19, - P20, - P21, -) +from _props import aa_props, solution from pseaac import PSeAAC @@ -67,67 +24,28 @@ def _normalize_properties(property_dicts): def test_normalized_values(): """ - Test that normalized property dictionaries match expected NP values. + Test that normalized property matrix matches expected normalized values. Asserts ------- - All normalized property values match the corresponding NP values - for each amino acid. + All normalized property values match the hard-coded normalized matrix + for each amino acid and property. """ - # Use the imported P1-P21 and NP1-NP21 from _props - p_props = [ - P1, - P2, - P3, - P4, - P5, - P6, - P7, - P8, - P9, - P10, - P11, - P12, - P13, - P14, - P15, - P16, - P17, - P18, - P19, - P20, - P21, - ] - np_props = [ - NP1, - NP2, - NP3, - NP4, - NP5, - NP6, - NP7, - NP8, - NP9, - NP10, - NP11, - NP12, - NP13, - NP14, - NP15, - NP16, - NP17, - NP18, - NP19, - NP20, - NP21, - ] - normalized = _normalize_properties(p_props) - for i in range(21): - np_dict = np_props[i] - norm_dict = normalized[i] - for aa in np_dict: - assert np_dict[aa] == norm_dict[aa], ( - f"Mismatch in NP{i + 1} for {aa}: {np_dict[aa]} != {norm_dict[aa]}" + # Get original and normalized property matrices as DataFrames + original_df = aa_props(type="pandas", normalize=False) + normalized_df = aa_props(type="pandas", normalize=True) + + # Manually normalize the original matrix (z-score, column-wise, + # rounded to 3 decimals) + manual_norm = (original_df - original_df.mean()) / original_df.std(ddof=0) + manual_norm = manual_norm.round(3) + + # Compare each value + for aa in original_df.index: + for prop in original_df.columns: + assert normalized_df.loc[aa, prop] == manual_norm.loc[aa, prop], ( + f"Mismatch for {aa}, {prop}: " + f"{normalized_df.loc[aa, prop]} != {manual_norm.loc[aa, prop]}" ) @@ -137,358 +55,7 @@ def test_normalized_values(): [ ( "ACDFFKKIIKKLLMMNNPPQQQRRRRIIIIRRR", - [ - 0.012, - 0.012, - 0.012, - 0.0, - 0.025, - 0.0, - 0.0, - 0.074, - 0.05, - 0.025, - 0.025, - 0.025, - 0.025, - 0.037, - 0.087, - 0.0, - 0.0, - 0.0, - 0.0, - 0.0, - 0.008, - 0.01, - 0.005, - 0.007, - 0.014, - 0.012, - 0.002, - 0.006, - 0.016, - 0.013, - 0.007, - 0.007, - 0.005, - 0.005, - 0.007, - 0.006, - 0.003, - 0.005, - 0.01, - 0.013, - 0.028, - 0.048, - 0.053, - 0.069, - 0.055, - 0.029, - 0.034, - 0.023, - 0.074, - 0.177, - 0.016, - 0.016, - 0.016, - 0.0, - 0.031, - 0.0, - 0.0, - 0.094, - 0.063, - 0.031, - 0.031, - 0.031, - 0.031, - 0.047, - 0.11, - 0.0, - 0.0, - 0.0, - 0.0, - 0.0, - 0.007, - 0.012, - 0.017, - 0.012, - 0.005, - 0.009, - 0.017, - 0.013, - 0.007, - 0.013, - 0.01, - 0.01, - 0.022, - 0.017, - 0.009, - 0.013, - 0.013, - 0.012, - 0.012, - 0.019, - 0.018, - 0.02, - 0.022, - 0.022, - 0.038, - 0.049, - 0.057, - 0.073, - 0.066, - 0.074, - 0.012, - 0.012, - 0.012, - 0.0, - 0.025, - 0.0, - 0.0, - 0.074, - 0.05, - 0.025, - 0.025, - 0.025, - 0.025, - 0.037, - 0.087, - 0.0, - 0.0, - 0.0, - 0.0, - 0.0, - 0.009, - 0.01, - 0.016, - 0.01, - 0.002, - 0.01, - 0.018, - 0.011, - 0.003, - 0.011, - 0.011, - 0.012, - 0.02, - 0.011, - 0.01, - 0.011, - 0.014, - 0.015, - 0.017, - 0.022, - 0.025, - 0.03, - 0.033, - 0.015, - 0.039, - 0.04, - 0.047, - 0.094, - 0.074, - 0.108, - 0.019, - 0.019, - 0.019, - 0.0, - 0.039, - 0.0, - 0.0, - 0.117, - 0.078, - 0.039, - 0.039, - 0.039, - 0.039, - 0.058, - 0.136, - 0.0, - 0.0, - 0.0, - 0.0, - 0.0, - 0.004, - 0.007, - 0.01, - 0.008, - 0.006, - 0.01, - 0.013, - 0.009, - 0.005, - 0.009, - 0.011, - 0.011, - 0.017, - 0.012, - 0.036, - 0.06, - 0.051, - 0.031, - 0.007, - 0.006, - 0.006, - 0.005, - 0.006, - 0.01, - 0.031, - 0.05, - 0.058, - 0.063, - 0.039, - 0.019, - 0.015, - 0.015, - 0.015, - 0.0, - 0.031, - 0.0, - 0.0, - 0.092, - 0.061, - 0.031, - 0.031, - 0.031, - 0.031, - 0.046, - 0.107, - 0.0, - 0.0, - 0.0, - 0.0, - 0.0, - 0.005, - 0.006, - 0.009, - 0.004, - 0.004, - 0.016, - 0.023, - 0.01, - 0.001, - 0.007, - 0.009, - 0.008, - 0.012, - 0.007, - 0.01, - 0.011, - 0.004, - 0.01, - 0.008, - 0.012, - 0.01, - 0.011, - 0.012, - 0.017, - 0.056, - 0.086, - 0.101, - 0.115, - 0.07, - 0.041, - 0.009, - 0.009, - 0.009, - 0.0, - 0.018, - 0.0, - 0.0, - 0.053, - 0.035, - 0.018, - 0.018, - 0.018, - 0.018, - 0.027, - 0.062, - 0.0, - 0.0, - 0.0, - 0.0, - 0.0, - 0.006, - 0.009, - 0.011, - 0.012, - 0.01, - 0.01, - 0.011, - 0.012, - 0.012, - 0.012, - 0.009, - 0.008, - 0.006, - 0.004, - 0.012, - 0.02, - 0.011, - 0.004, - 0.007, - 0.024, - 0.037, - 0.044, - 0.049, - 0.037, - 0.031, - 0.03, - 0.036, - 0.074, - 0.113, - 0.163, - 0.011, - 0.011, - 0.011, - 0.0, - 0.021, - 0.0, - 0.0, - 0.064, - 0.043, - 0.021, - 0.021, - 0.021, - 0.021, - 0.032, - 0.075, - 0.0, - 0.0, - 0.0, - 0.0, - 0.0, - 0.014, - 0.008, - 0.009, - 0.015, - 0.007, - 0.004, - 0.005, - 0.008, - 0.008, - 0.005, - 0.007, - 0.003, - 0.004, - 0.015, - 0.013, - 0.008, - 0.008, - 0.015, - 0.016, - 0.023, - 0.04, - 0.05, - 0.054, - 0.051, - 0.023, - 0.016, - 0.018, - 0.039, - 0.118, - 0.182, - ], + solution, ) ], ) diff --git a/pyaptamer/AptaNet/utils.py b/pyaptamer/utils.py similarity index 100% rename from pyaptamer/AptaNet/utils.py rename to pyaptamer/utils.py From dc78e44619f8acea054d07b5d21b283cf468d175 Mon Sep 17 00:00:00 2001 From: satvshr Date: Fri, 11 Jul 2025 09:01:17 +0530 Subject: [PATCH 015/145] Removed lint. from pyproject, will push it as a separate PR --- pyproject.toml | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/pyproject.toml b/pyproject.toml index f7905493..93089c41 100644 --- a/pyproject.toml +++ b/pyproject.toml @@ -28,7 +28,7 @@ line-length = 88 target-version = "py310" # Match your `>=3.10` requirement # Choose what to check for -lint.select = ["E", "F", "B", "I", "UP", "N", "C4"] +select = ["E", "F", "B", "I", "UP", "N", "C4"] exclude = ["__pycache__", ".venv", "build", "dist", ".git"] From c34798872df02592fffa92dd766070da4ac04aa7 Mon Sep 17 00:00:00 2001 From: satvshr Date: Fri, 11 Jul 2025 09:11:53 +0530 Subject: [PATCH 016/145] Refactored code --- pyaptamer/AptaNet/pseaac.py | 38 ++++++-------------------------- pyaptamer/AptaNet/test_pseaac.py | 18 --------------- 2 files changed, 7 insertions(+), 49 deletions(-) diff --git a/pyaptamer/AptaNet/pseaac.py b/pyaptamer/AptaNet/pseaac.py index 5e2ec3a0..b3cb16ca 100644 --- a/pyaptamer/AptaNet/pseaac.py +++ b/pyaptamer/AptaNet/pseaac.py @@ -1,7 +1,7 @@ import numpy as np from _props import aa_props -from pyaptamer.utils import is_valid_aa +from pyaptamer.utils import AMINO_ACIDS, is_valid_aa class PSeAAC: @@ -32,28 +32,6 @@ def __init__(self): """ Initialize PSeAAC with a protein sequence. """ - self.amino_acid = [ - "A", - "C", - "D", - "E", - "F", - "G", - "H", - "I", - "K", - "L", - "M", - "N", - "P", - "Q", - "R", - "S", - "T", - "V", - "W", - "Y", - ] # Load normalized property matrix (20x21, rows=AA, cols=NP1-NP21) self.np_matrix = aa_props(type="numpy", normalize=True) @@ -86,10 +64,8 @@ def _average_aa(self, seq): from collections import Counter counts = Counter(seq) - total = len(self.amino_acid) - return { - aa: counts.get(aa, 0) / total if total > 0 else 0 for aa in self.amino_acid - } + total = len(AMINO_ACIDS) + return {aa: counts.get(aa, 0) / total if total > 0 else 0 for aa in AMINO_ACIDS} def _theta_rirj(self, ri, rj, prop_group): """ @@ -109,8 +85,8 @@ def _theta_rirj(self, ri, rj, prop_group): float Theta value. """ - idx_ri = self.amino_acid.index(ri) - idx_rj = self.amino_acid.index(rj) + idx_ri = AMINO_ACIDS.index(ri) + idx_rj = AMINO_ACIDS.index(rj) diffs = ( self.np_matrix[idx_rj, list(prop_group)] - self.np_matrix[idx_ri, list(prop_group)] @@ -151,7 +127,7 @@ def transform(self, protein_sequence): if not is_valid_aa(protein_sequence): raise ValueError( "Invalid amino acid found in protein_sequence. Only " - f"{''.join(self.amino_acid)} are allowed." + f"{''.join(AMINO_ACIDS)} are allowed." ) lambda_val = 30 @@ -181,7 +157,7 @@ def transform(self, protein_sequence): denominator_val = sum_all_aa_freq + (weight * sum_all_theta_val) # First 20 features: normalized amino acid composition - aa_composition = np.array([aa_freq[aa] for aa in self.amino_acid]) + aa_composition = np.array([aa_freq[aa] for aa in AMINO_ACIDS]) all_pseaac.extend(np.round(aa_composition / denominator_val, 3)) # Next 30 features: theta values diff --git a/pyaptamer/AptaNet/test_pseaac.py b/pyaptamer/AptaNet/test_pseaac.py index 20415ec1..da25607e 100644 --- a/pyaptamer/AptaNet/test_pseaac.py +++ b/pyaptamer/AptaNet/test_pseaac.py @@ -4,24 +4,6 @@ from pseaac import PSeAAC -def _normalize_properties(property_dicts): - """ - Takes multiple amino acid property dictionaries and returns their - normalized versions. - Normalization: (value - mean) / std deviation - Returns a list of normalized dictionaries in the same order. - """ - normalized = [] - for prop in property_dicts: - values = list(prop.values()) - mean_val = sum(values) / len(values) - std_val = (sum((v - mean_val) ** 2 for v in values) / len(values)) ** 0.5 - normalized.append( - {aa: round((val - mean_val) / std_val, 3) for aa, val in prop.items()} - ) - return normalized - - def test_normalized_values(): """ Test that normalized property matrix matches expected normalized values. From d9537f46a73dc695a125d8a2042ca0510c3dcf6d Mon Sep 17 00:00:00 2001 From: satvshr Date: Fri, 11 Jul 2025 13:27:23 +0530 Subject: [PATCH 017/145] Added pandas as a dependancy --- pyproject.toml | 3 ++- 1 file changed, 2 insertions(+), 1 deletion(-) diff --git a/pyproject.toml b/pyproject.toml index 93089c41..0a357e66 100644 --- a/pyproject.toml +++ b/pyproject.toml @@ -13,7 +13,8 @@ authors = [ ] dependencies = [ - "openmm>=8.3.0,<8.4.0" + "openmm>=8.3.0,<8.4.0", + "pandas>=2.0.0" ] [project.optional-dependencies] From 1c46c55305fc65bb9ecad171d0d05bf500ae2714 Mon Sep 17 00:00:00 2001 From: satvshr Date: Fri, 11 Jul 2025 13:33:40 +0530 Subject: [PATCH 018/145] Renamed parent folder name to put it in the same level as AptaNet --- pyaptamer/{AptaNet => PSeAAC}/_props.py | 0 pyaptamer/{AptaNet => PSeAAC}/pseaac.py | 0 pyaptamer/{AptaNet => PSeAAC}/test_pseaac.py | 0 3 files changed, 0 insertions(+), 0 deletions(-) rename pyaptamer/{AptaNet => PSeAAC}/_props.py (100%) rename pyaptamer/{AptaNet => PSeAAC}/pseaac.py (100%) rename pyaptamer/{AptaNet => PSeAAC}/test_pseaac.py (100%) diff --git a/pyaptamer/AptaNet/_props.py b/pyaptamer/PSeAAC/_props.py similarity index 100% rename from pyaptamer/AptaNet/_props.py rename to pyaptamer/PSeAAC/_props.py diff --git a/pyaptamer/AptaNet/pseaac.py b/pyaptamer/PSeAAC/pseaac.py similarity index 100% rename from pyaptamer/AptaNet/pseaac.py rename to pyaptamer/PSeAAC/pseaac.py diff --git a/pyaptamer/AptaNet/test_pseaac.py b/pyaptamer/PSeAAC/test_pseaac.py similarity index 100% rename from pyaptamer/AptaNet/test_pseaac.py rename to pyaptamer/PSeAAC/test_pseaac.py From 7781441d89bc92a4db3f25889658d0ab63bd8eda Mon Sep 17 00:00:00 2001 From: satvshr Date: Mon, 14 Jul 2025 15:18:12 +0530 Subject: [PATCH 019/145] Refactored code and made architecture flexible --- pyaptamer/PSeAAC/__init__.py | 1 + pyaptamer/PSeAAC/_props.py | 367 +------------------- pyaptamer/PSeAAC/pseaac.py | 2 +- pyaptamer/PSeAAC/tests/__init__.py | 1 + pyaptamer/PSeAAC/tests/_props.py | 352 +++++++++++++++++++ pyaptamer/PSeAAC/{ => tests}/test_pseaac.py | 7 +- 6 files changed, 370 insertions(+), 360 deletions(-) create mode 100644 pyaptamer/PSeAAC/__init__.py create mode 100644 pyaptamer/PSeAAC/tests/__init__.py create mode 100644 pyaptamer/PSeAAC/tests/_props.py rename pyaptamer/PSeAAC/{ => tests}/test_pseaac.py (94%) diff --git a/pyaptamer/PSeAAC/__init__.py b/pyaptamer/PSeAAC/__init__.py new file mode 100644 index 00000000..0bd1cfb2 --- /dev/null +++ b/pyaptamer/PSeAAC/__init__.py @@ -0,0 +1 @@ +"""The PSeAAC encoding algorithm""" diff --git a/pyaptamer/PSeAAC/_props.py b/pyaptamer/PSeAAC/_props.py index 0c750a16..dfa04da0 100644 --- a/pyaptamer/PSeAAC/_props.py +++ b/pyaptamer/PSeAAC/_props.py @@ -19,6 +19,7 @@ def aa_props(type="numpy", normalize=True): References ---------- + - https://github.com/nedaemami/AptaNet/blob/main/feature_extraction.py - Hydrophobicity values are from JACS, 1962, 84: 4240-4246. (C. Tanford) - Hydrophilicity values are from PNAS, 1981, 78:3824-3828 (T.P.Hopp & K.R.Woods) - Side-chain mass for each of the 20 amino acids. @@ -51,12 +52,18 @@ def aa_props(type="numpy", normalize=True): If 'pandas', returns a DataFrame with amino acid and property labels. If 'numpy', returns a numpy array. normalize : bool, default=True - If True, returns z-score normalized properties (column-wise). + If True, each property column is standardized using z-score normalization: + the mean value is subtracted and the result is divided by the standard + deviation across the 20 amino acids — i.e., (x - mean) / std. + This rescales each property to have zero mean and unit variance for + comparability. Returns ------- - props : pandas.DataFrame or numpy.ndarray - Amino acid property matrix. Rows are amino acids, columns are properties. + props : numpy.ndarray or pandas.DataFrame (depending on `type`) + - Rows: standard amino acids (A, C, D, ..., Y) + - Columns: physicochemical properties (P1–P21) + - Entries: raw or normalized property values depending on `normalize`. Examples -------- @@ -1050,357 +1057,3 @@ def aa_props(type="numpy", normalize=True): return props else: raise ValueError("type must be 'numpy' or 'pandas'") - - -solution = [ - 0.012, - 0.012, - 0.012, - 0.0, - 0.025, - 0.0, - 0.0, - 0.074, - 0.05, - 0.025, - 0.025, - 0.025, - 0.025, - 0.037, - 0.087, - 0.0, - 0.0, - 0.0, - 0.0, - 0.0, - 0.008, - 0.01, - 0.005, - 0.007, - 0.014, - 0.012, - 0.002, - 0.006, - 0.016, - 0.013, - 0.007, - 0.007, - 0.005, - 0.005, - 0.007, - 0.006, - 0.003, - 0.005, - 0.01, - 0.013, - 0.028, - 0.048, - 0.053, - 0.069, - 0.055, - 0.029, - 0.034, - 0.023, - 0.074, - 0.177, - 0.016, - 0.016, - 0.016, - 0.0, - 0.031, - 0.0, - 0.0, - 0.094, - 0.063, - 0.031, - 0.031, - 0.031, - 0.031, - 0.047, - 0.11, - 0.0, - 0.0, - 0.0, - 0.0, - 0.0, - 0.007, - 0.012, - 0.017, - 0.012, - 0.005, - 0.009, - 0.017, - 0.013, - 0.007, - 0.013, - 0.01, - 0.01, - 0.022, - 0.017, - 0.009, - 0.013, - 0.013, - 0.012, - 0.012, - 0.019, - 0.018, - 0.02, - 0.022, - 0.022, - 0.038, - 0.049, - 0.057, - 0.073, - 0.066, - 0.074, - 0.012, - 0.012, - 0.012, - 0.0, - 0.025, - 0.0, - 0.0, - 0.074, - 0.05, - 0.025, - 0.025, - 0.025, - 0.025, - 0.037, - 0.087, - 0.0, - 0.0, - 0.0, - 0.0, - 0.0, - 0.009, - 0.01, - 0.016, - 0.01, - 0.002, - 0.01, - 0.018, - 0.011, - 0.003, - 0.011, - 0.011, - 0.012, - 0.02, - 0.011, - 0.01, - 0.011, - 0.014, - 0.015, - 0.017, - 0.022, - 0.025, - 0.03, - 0.033, - 0.015, - 0.039, - 0.04, - 0.047, - 0.094, - 0.074, - 0.108, - 0.019, - 0.019, - 0.019, - 0.0, - 0.039, - 0.0, - 0.0, - 0.117, - 0.078, - 0.039, - 0.039, - 0.039, - 0.039, - 0.058, - 0.136, - 0.0, - 0.0, - 0.0, - 0.0, - 0.0, - 0.004, - 0.007, - 0.01, - 0.008, - 0.006, - 0.01, - 0.013, - 0.009, - 0.005, - 0.009, - 0.011, - 0.011, - 0.017, - 0.012, - 0.036, - 0.06, - 0.051, - 0.031, - 0.007, - 0.006, - 0.006, - 0.005, - 0.006, - 0.01, - 0.031, - 0.05, - 0.058, - 0.063, - 0.039, - 0.019, - 0.015, - 0.015, - 0.015, - 0.0, - 0.031, - 0.0, - 0.0, - 0.092, - 0.061, - 0.031, - 0.031, - 0.031, - 0.031, - 0.046, - 0.107, - 0.0, - 0.0, - 0.0, - 0.0, - 0.0, - 0.005, - 0.006, - 0.009, - 0.004, - 0.004, - 0.016, - 0.023, - 0.01, - 0.001, - 0.007, - 0.009, - 0.008, - 0.012, - 0.007, - 0.01, - 0.011, - 0.004, - 0.01, - 0.008, - 0.012, - 0.01, - 0.011, - 0.012, - 0.017, - 0.056, - 0.086, - 0.101, - 0.115, - 0.07, - 0.041, - 0.009, - 0.009, - 0.009, - 0.0, - 0.018, - 0.0, - 0.0, - 0.053, - 0.035, - 0.018, - 0.018, - 0.018, - 0.018, - 0.027, - 0.062, - 0.0, - 0.0, - 0.0, - 0.0, - 0.0, - 0.006, - 0.009, - 0.011, - 0.012, - 0.01, - 0.01, - 0.011, - 0.012, - 0.012, - 0.012, - 0.009, - 0.008, - 0.006, - 0.004, - 0.012, - 0.02, - 0.011, - 0.004, - 0.007, - 0.024, - 0.037, - 0.044, - 0.049, - 0.037, - 0.031, - 0.03, - 0.036, - 0.074, - 0.113, - 0.163, - 0.011, - 0.011, - 0.011, - 0.0, - 0.021, - 0.0, - 0.0, - 0.064, - 0.043, - 0.021, - 0.021, - 0.021, - 0.021, - 0.032, - 0.075, - 0.0, - 0.0, - 0.0, - 0.0, - 0.0, - 0.014, - 0.008, - 0.009, - 0.015, - 0.007, - 0.004, - 0.005, - 0.008, - 0.008, - 0.005, - 0.007, - 0.003, - 0.004, - 0.015, - 0.013, - 0.008, - 0.008, - 0.015, - 0.016, - 0.023, - 0.04, - 0.05, - 0.054, - 0.051, - 0.023, - 0.016, - 0.018, - 0.039, - 0.118, - 0.182, -] diff --git a/pyaptamer/PSeAAC/pseaac.py b/pyaptamer/PSeAAC/pseaac.py index b3cb16ca..d69f82a3 100644 --- a/pyaptamer/PSeAAC/pseaac.py +++ b/pyaptamer/PSeAAC/pseaac.py @@ -1,6 +1,6 @@ import numpy as np -from _props import aa_props +from pyaptamer.PSeAAC._props import aa_props from pyaptamer.utils import AMINO_ACIDS, is_valid_aa diff --git a/pyaptamer/PSeAAC/tests/__init__.py b/pyaptamer/PSeAAC/tests/__init__.py new file mode 100644 index 00000000..a5195250 --- /dev/null +++ b/pyaptamer/PSeAAC/tests/__init__.py @@ -0,0 +1 @@ +"""Tests for the PSeAAC encoding algorithm.""" diff --git a/pyaptamer/PSeAAC/tests/_props.py b/pyaptamer/PSeAAC/tests/_props.py new file mode 100644 index 00000000..d711d14e --- /dev/null +++ b/pyaptamer/PSeAAC/tests/_props.py @@ -0,0 +1,352 @@ +solution = [ + 0.012, + 0.012, + 0.012, + 0.0, + 0.025, + 0.0, + 0.0, + 0.074, + 0.05, + 0.025, + 0.025, + 0.025, + 0.025, + 0.037, + 0.087, + 0.0, + 0.0, + 0.0, + 0.0, + 0.0, + 0.008, + 0.01, + 0.005, + 0.007, + 0.014, + 0.012, + 0.002, + 0.006, + 0.016, + 0.013, + 0.007, + 0.007, + 0.005, + 0.005, + 0.007, + 0.006, + 0.003, + 0.005, + 0.01, + 0.013, + 0.028, + 0.048, + 0.053, + 0.069, + 0.055, + 0.029, + 0.034, + 0.023, + 0.074, + 0.177, + 0.016, + 0.016, + 0.016, + 0.0, + 0.031, + 0.0, + 0.0, + 0.094, + 0.063, + 0.031, + 0.031, + 0.031, + 0.031, + 0.047, + 0.11, + 0.0, + 0.0, + 0.0, + 0.0, + 0.0, + 0.007, + 0.012, + 0.017, + 0.012, + 0.005, + 0.009, + 0.017, + 0.013, + 0.007, + 0.013, + 0.01, + 0.01, + 0.022, + 0.017, + 0.009, + 0.013, + 0.013, + 0.012, + 0.012, + 0.019, + 0.018, + 0.02, + 0.022, + 0.022, + 0.038, + 0.049, + 0.057, + 0.073, + 0.066, + 0.074, + 0.012, + 0.012, + 0.012, + 0.0, + 0.025, + 0.0, + 0.0, + 0.074, + 0.05, + 0.025, + 0.025, + 0.025, + 0.025, + 0.037, + 0.087, + 0.0, + 0.0, + 0.0, + 0.0, + 0.0, + 0.009, + 0.01, + 0.016, + 0.01, + 0.002, + 0.01, + 0.018, + 0.011, + 0.003, + 0.011, + 0.011, + 0.012, + 0.02, + 0.011, + 0.01, + 0.011, + 0.014, + 0.015, + 0.017, + 0.022, + 0.025, + 0.03, + 0.033, + 0.015, + 0.039, + 0.04, + 0.047, + 0.094, + 0.074, + 0.108, + 0.019, + 0.019, + 0.019, + 0.0, + 0.039, + 0.0, + 0.0, + 0.117, + 0.078, + 0.039, + 0.039, + 0.039, + 0.039, + 0.058, + 0.136, + 0.0, + 0.0, + 0.0, + 0.0, + 0.0, + 0.004, + 0.007, + 0.01, + 0.008, + 0.006, + 0.01, + 0.013, + 0.009, + 0.005, + 0.009, + 0.011, + 0.011, + 0.017, + 0.012, + 0.036, + 0.06, + 0.051, + 0.031, + 0.007, + 0.006, + 0.006, + 0.005, + 0.006, + 0.01, + 0.031, + 0.05, + 0.058, + 0.063, + 0.039, + 0.019, + 0.015, + 0.015, + 0.015, + 0.0, + 0.031, + 0.0, + 0.0, + 0.092, + 0.061, + 0.031, + 0.031, + 0.031, + 0.031, + 0.046, + 0.107, + 0.0, + 0.0, + 0.0, + 0.0, + 0.0, + 0.005, + 0.006, + 0.009, + 0.004, + 0.004, + 0.016, + 0.023, + 0.01, + 0.001, + 0.007, + 0.009, + 0.008, + 0.012, + 0.007, + 0.01, + 0.011, + 0.004, + 0.01, + 0.008, + 0.012, + 0.01, + 0.011, + 0.012, + 0.017, + 0.056, + 0.086, + 0.101, + 0.115, + 0.07, + 0.041, + 0.009, + 0.009, + 0.009, + 0.0, + 0.018, + 0.0, + 0.0, + 0.053, + 0.035, + 0.018, + 0.018, + 0.018, + 0.018, + 0.027, + 0.062, + 0.0, + 0.0, + 0.0, + 0.0, + 0.0, + 0.006, + 0.009, + 0.011, + 0.012, + 0.01, + 0.01, + 0.011, + 0.012, + 0.012, + 0.012, + 0.009, + 0.008, + 0.006, + 0.004, + 0.012, + 0.02, + 0.011, + 0.004, + 0.007, + 0.024, + 0.037, + 0.044, + 0.049, + 0.037, + 0.031, + 0.03, + 0.036, + 0.074, + 0.113, + 0.163, + 0.011, + 0.011, + 0.011, + 0.0, + 0.021, + 0.0, + 0.0, + 0.064, + 0.043, + 0.021, + 0.021, + 0.021, + 0.021, + 0.032, + 0.075, + 0.0, + 0.0, + 0.0, + 0.0, + 0.0, + 0.014, + 0.008, + 0.009, + 0.015, + 0.007, + 0.004, + 0.005, + 0.008, + 0.008, + 0.005, + 0.007, + 0.003, + 0.004, + 0.015, + 0.013, + 0.008, + 0.008, + 0.015, + 0.016, + 0.023, + 0.04, + 0.05, + 0.054, + 0.051, + 0.023, + 0.016, + 0.018, + 0.039, + 0.118, + 0.182, +] diff --git a/pyaptamer/PSeAAC/test_pseaac.py b/pyaptamer/PSeAAC/tests/test_pseaac.py similarity index 94% rename from pyaptamer/PSeAAC/test_pseaac.py rename to pyaptamer/PSeAAC/tests/test_pseaac.py index da25607e..20043767 100644 --- a/pyaptamer/PSeAAC/test_pseaac.py +++ b/pyaptamer/PSeAAC/tests/test_pseaac.py @@ -1,7 +1,10 @@ import numpy as np import pytest -from _props import aa_props, solution -from pseaac import PSeAAC + +from pyaptamer.PSeAAC.pseaac import PSeAAC +from pyaptamer.PSeAAC.tests._props import solution + +from .._props import aa_props def test_normalized_values(): From e762cc8ba3916592e72bc728e65b1f7fddca7228 Mon Sep 17 00:00:00 2001 From: satvshr Date: Mon, 14 Jul 2025 16:04:25 +0530 Subject: [PATCH 020/145] Edited docstrings and directory structure --- pyaptamer/PSeAAC/_props.py | 33 ++++++++++++++----- pyaptamer/PSeAAC/{pseaac.py => features.py} | 32 +++++++++++++++--- pyaptamer/PSeAAC/tests/test_pseaac.py | 7 ++-- .../{utils.py => _utils/pseaac_utils.py} | 6 ++-- 4 files changed, 59 insertions(+), 19 deletions(-) rename pyaptamer/PSeAAC/{pseaac.py => features.py} (80%) rename pyaptamer/{utils.py => _utils/pseaac_utils.py} (83%) diff --git a/pyaptamer/PSeAAC/_props.py b/pyaptamer/PSeAAC/_props.py index dfa04da0..f5aef9f4 100644 --- a/pyaptamer/PSeAAC/_props.py +++ b/pyaptamer/PSeAAC/_props.py @@ -9,13 +9,28 @@ def aa_props(type="numpy", normalize=True): This function provides a 20x21 matrix of physicochemical properties for the 20 standard amino acids. Each row corresponds to an amino acid (in the order: A, C, D, E, F, G, H, I, K, L, M, N, P, Q, R, S, T, V, W, Y), and each column - corresponds to a property (P1–P21). The properties include hydrophobicity, - hydrophilicity, side-chain mass, polarity, molecular weight, melting point, - transfer free energy, buriability, bulkiness, - solvation free energy, relative mutability, residue volume, volume, amino acid - distribution, hydration number, isoelectric point, compressibility, chromatographic - index, unfolding entropy change, unfolding enthalpy change, and unfolding Gibbs free - energy change. + corresponds to a property (P1–P21). The properties are in the order: + - Hydrophobicity + - Hydrophilicity + - Side-chain Mass + - Polarity + - Molecular Weight + - Melting Point + - Transfer Free Energy + - Buriability + - Bulkiness + - Solvation Free Energy + - Relative Mutability + - Residue Volume + - Volume + - Amino Acid Distribution + - Hydration Number + - Isoelectric Point + - Compressibility + - Chromatographic Index + - Unfolding Entropy Change + - Unfolding Enthalpy Change + - Unfolding Gibbs Free Energy Change References ---------- @@ -62,7 +77,9 @@ def aa_props(type="numpy", normalize=True): ------- props : numpy.ndarray or pandas.DataFrame (depending on `type`) - Rows: standard amino acids (A, C, D, ..., Y) - - Columns: physicochemical properties (P1–P21) + - Columns: physicochemical properties (P1–P21) of the standard amino acids, as + mentioned in the original implementation: + https://github.com/nedaemami/AptaNet/blob/main/feature_extraction.py - Entries: raw or normalized property values depending on `normalize`. Examples diff --git a/pyaptamer/PSeAAC/pseaac.py b/pyaptamer/PSeAAC/features.py similarity index 80% rename from pyaptamer/PSeAAC/pseaac.py rename to pyaptamer/PSeAAC/features.py index d69f82a3..802f9fb8 100644 --- a/pyaptamer/PSeAAC/pseaac.py +++ b/pyaptamer/PSeAAC/features.py @@ -1,7 +1,7 @@ import numpy as np -from pyaptamer.PSeAAC._props import aa_props -from pyaptamer.utils import AMINO_ACIDS, is_valid_aa +from pyaptamer._utils.pseaac_utils import AMINO_ACIDS, is_valid_aa +from pyaptamer.pseaac._props import aa_props class PSeAAC: @@ -122,7 +122,31 @@ def _sum_theta_val(self, seq, seq_len, lambda_val, n, prop_group): def transform(self, protein_sequence): """ - Generate the PseAAC feature vector for the protein sequence. + Generate the PseAAC feature vector for the given protein sequence. + + This method computes a set of features based on amino acid composition + and sequence-order correlations using physicochemical properties, as + described in the Pseudo Amino Acid Composition (PseAAC) model. + + Parameters + ---------- + protein_sequence : str + The input protein sequence consisting of valid amino acid characters + (A, C, D, E, F, G, H, I, K, L, M, N, P, Q, R, S, T, V, W, Y). + + Returns + ------- + np.ndarray + A 1D NumPy array of length 50 * len(prop_groups), where each 50-element + block consists of: + - 20 normalized amino acid composition features + - 30 normalized sequence-order correlation factors (theta values) + + Raises + ------ + ValueError + If the sequence contains invalid amino acids or is shorter than + the required lambda value (default = 30). """ if not is_valid_aa(protein_sequence): raise ValueError( @@ -163,4 +187,4 @@ def transform(self, protein_sequence): # Next 30 features: theta values all_pseaac.extend(np.round((weight * all_theta_val) / denominator_val, 3)) - return all_pseaac + return np.array(all_pseaac) diff --git a/pyaptamer/PSeAAC/tests/test_pseaac.py b/pyaptamer/PSeAAC/tests/test_pseaac.py index 20043767..93ea150f 100644 --- a/pyaptamer/PSeAAC/tests/test_pseaac.py +++ b/pyaptamer/PSeAAC/tests/test_pseaac.py @@ -1,10 +1,9 @@ import numpy as np import pytest -from pyaptamer.PSeAAC.pseaac import PSeAAC -from pyaptamer.PSeAAC.tests._props import solution - -from .._props import aa_props +from pyaptamer.pseaac._props import aa_props +from pyaptamer.pseaac.features import PSeAAC +from pyaptamer.pseaac.tests._props import solution def test_normalized_values(): diff --git a/pyaptamer/utils.py b/pyaptamer/_utils/pseaac_utils.py similarity index 83% rename from pyaptamer/utils.py rename to pyaptamer/_utils/pseaac_utils.py index 55805ea7..02911dc7 100644 --- a/pyaptamer/utils.py +++ b/pyaptamer/_utils/pseaac_utils.py @@ -1,8 +1,8 @@ """ -Utility functions for amino acid sequence validation in AptaNet. +Utility functions for amino acid sequence validation in PSeAAC. This module provides helper functions for checking whether a string consists only of -valid amino acid single-letter codes (the 20 standard amino acids). The set AMINO_ACIDS +valid amino acid single-letter codes (the 20 standard amino acids). The list AMINO_ACIDS is used for efficient membership testing. Functions @@ -12,7 +12,7 @@ codes, False otherwise. """ -AMINO_ACIDS = set("ACDEFGHIKLMNPQRSTVWY") +AMINO_ACIDS = list("ACDEFGHIKLMNPQRSTVWY") def is_valid_aa(seq): From f9392efc636471a353fe7b9cb0e0759d4961be46 Mon Sep 17 00:00:00 2001 From: satvshr Date: Mon, 14 Jul 2025 16:12:55 +0530 Subject: [PATCH 021/145] weird rename experiment --- pyaptamer/{PSeAAC => hi}/__init__.py | 0 pyaptamer/{PSeAAC => hi}/_props.py | 0 pyaptamer/{PSeAAC => hi}/features.py | 2 +- pyaptamer/{PSeAAC => hi}/tests/__init__.py | 0 pyaptamer/{PSeAAC => hi}/tests/_props.py | 0 pyaptamer/{PSeAAC => hi}/tests/test_pseaac.py | 6 +++--- 6 files changed, 4 insertions(+), 4 deletions(-) rename pyaptamer/{PSeAAC => hi}/__init__.py (100%) rename pyaptamer/{PSeAAC => hi}/_props.py (100%) rename pyaptamer/{PSeAAC => hi}/features.py (99%) rename pyaptamer/{PSeAAC => hi}/tests/__init__.py (100%) rename pyaptamer/{PSeAAC => hi}/tests/_props.py (100%) rename pyaptamer/{PSeAAC => hi}/tests/test_pseaac.py (93%) diff --git a/pyaptamer/PSeAAC/__init__.py b/pyaptamer/hi/__init__.py similarity index 100% rename from pyaptamer/PSeAAC/__init__.py rename to pyaptamer/hi/__init__.py diff --git a/pyaptamer/PSeAAC/_props.py b/pyaptamer/hi/_props.py similarity index 100% rename from pyaptamer/PSeAAC/_props.py rename to pyaptamer/hi/_props.py diff --git a/pyaptamer/PSeAAC/features.py b/pyaptamer/hi/features.py similarity index 99% rename from pyaptamer/PSeAAC/features.py rename to pyaptamer/hi/features.py index 802f9fb8..6a44f1c2 100644 --- a/pyaptamer/PSeAAC/features.py +++ b/pyaptamer/hi/features.py @@ -1,7 +1,7 @@ import numpy as np from pyaptamer._utils.pseaac_utils import AMINO_ACIDS, is_valid_aa -from pyaptamer.pseaac._props import aa_props +from pyaptamer.hi._props import aa_props class PSeAAC: diff --git a/pyaptamer/PSeAAC/tests/__init__.py b/pyaptamer/hi/tests/__init__.py similarity index 100% rename from pyaptamer/PSeAAC/tests/__init__.py rename to pyaptamer/hi/tests/__init__.py diff --git a/pyaptamer/PSeAAC/tests/_props.py b/pyaptamer/hi/tests/_props.py similarity index 100% rename from pyaptamer/PSeAAC/tests/_props.py rename to pyaptamer/hi/tests/_props.py diff --git a/pyaptamer/PSeAAC/tests/test_pseaac.py b/pyaptamer/hi/tests/test_pseaac.py similarity index 93% rename from pyaptamer/PSeAAC/tests/test_pseaac.py rename to pyaptamer/hi/tests/test_pseaac.py index 93ea150f..3e171cb1 100644 --- a/pyaptamer/PSeAAC/tests/test_pseaac.py +++ b/pyaptamer/hi/tests/test_pseaac.py @@ -1,9 +1,9 @@ import numpy as np import pytest -from pyaptamer.pseaac._props import aa_props -from pyaptamer.pseaac.features import PSeAAC -from pyaptamer.pseaac.tests._props import solution +from pyaptamer.hi._props import aa_props +from pyaptamer.hi.features import PSeAAC +from pyaptamer.hi.tests._props import solution def test_normalized_values(): From beb45eca3b6a4753250cbd229363ddb83efe182d Mon Sep 17 00:00:00 2001 From: satvshr Date: Mon, 14 Jul 2025 16:13:12 +0530 Subject: [PATCH 022/145] weird rename experiment pt. 2 --- pyaptamer/{hi => pseaac}/__init__.py | 0 pyaptamer/{hi => pseaac}/_props.py | 0 pyaptamer/{hi => pseaac}/features.py | 2 +- pyaptamer/{hi => pseaac}/tests/__init__.py | 0 pyaptamer/{hi => pseaac}/tests/_props.py | 0 pyaptamer/{hi => pseaac}/tests/test_pseaac.py | 6 +++--- 6 files changed, 4 insertions(+), 4 deletions(-) rename pyaptamer/{hi => pseaac}/__init__.py (100%) rename pyaptamer/{hi => pseaac}/_props.py (100%) rename pyaptamer/{hi => pseaac}/features.py (99%) rename pyaptamer/{hi => pseaac}/tests/__init__.py (100%) rename pyaptamer/{hi => pseaac}/tests/_props.py (100%) rename pyaptamer/{hi => pseaac}/tests/test_pseaac.py (93%) diff --git a/pyaptamer/hi/__init__.py b/pyaptamer/pseaac/__init__.py similarity index 100% rename from pyaptamer/hi/__init__.py rename to pyaptamer/pseaac/__init__.py diff --git a/pyaptamer/hi/_props.py b/pyaptamer/pseaac/_props.py similarity index 100% rename from pyaptamer/hi/_props.py rename to pyaptamer/pseaac/_props.py diff --git a/pyaptamer/hi/features.py b/pyaptamer/pseaac/features.py similarity index 99% rename from pyaptamer/hi/features.py rename to pyaptamer/pseaac/features.py index 6a44f1c2..802f9fb8 100644 --- a/pyaptamer/hi/features.py +++ b/pyaptamer/pseaac/features.py @@ -1,7 +1,7 @@ import numpy as np from pyaptamer._utils.pseaac_utils import AMINO_ACIDS, is_valid_aa -from pyaptamer.hi._props import aa_props +from pyaptamer.pseaac._props import aa_props class PSeAAC: diff --git a/pyaptamer/hi/tests/__init__.py b/pyaptamer/pseaac/tests/__init__.py similarity index 100% rename from pyaptamer/hi/tests/__init__.py rename to pyaptamer/pseaac/tests/__init__.py diff --git a/pyaptamer/hi/tests/_props.py b/pyaptamer/pseaac/tests/_props.py similarity index 100% rename from pyaptamer/hi/tests/_props.py rename to pyaptamer/pseaac/tests/_props.py diff --git a/pyaptamer/hi/tests/test_pseaac.py b/pyaptamer/pseaac/tests/test_pseaac.py similarity index 93% rename from pyaptamer/hi/tests/test_pseaac.py rename to pyaptamer/pseaac/tests/test_pseaac.py index 3e171cb1..93ea150f 100644 --- a/pyaptamer/hi/tests/test_pseaac.py +++ b/pyaptamer/pseaac/tests/test_pseaac.py @@ -1,9 +1,9 @@ import numpy as np import pytest -from pyaptamer.hi._props import aa_props -from pyaptamer.hi.features import PSeAAC -from pyaptamer.hi.tests._props import solution +from pyaptamer.pseaac._props import aa_props +from pyaptamer.pseaac.features import PSeAAC +from pyaptamer.pseaac.tests._props import solution def test_normalized_values(): From d603d07ca0f389493c69ba760e4e9e16175c64ed Mon Sep 17 00:00:00 2001 From: satvshr Date: Mon, 14 Jul 2025 16:46:21 +0530 Subject: [PATCH 023/145] Made requested changes --- pyaptamer/pseaac/__init__.py | 4 ++++ pyaptamer/pseaac/{features.py => _features.py} | 4 ++-- pyaptamer/pseaac/tests/test_pseaac.py | 2 +- pyaptamer/{_utils/pseaac_utils.py => utils/_pseaac_utils.py} | 0 4 files changed, 7 insertions(+), 3 deletions(-) rename pyaptamer/pseaac/{features.py => _features.py} (97%) rename pyaptamer/{_utils/pseaac_utils.py => utils/_pseaac_utils.py} (100%) diff --git a/pyaptamer/pseaac/__init__.py b/pyaptamer/pseaac/__init__.py index 0bd1cfb2..13b1c9be 100644 --- a/pyaptamer/pseaac/__init__.py +++ b/pyaptamer/pseaac/__init__.py @@ -1 +1,5 @@ """The PSeAAC encoding algorithm""" + +from pyaptamer.pseaac._features import PSeAAC + +__all__ = ["PSeAAC"] diff --git a/pyaptamer/pseaac/features.py b/pyaptamer/pseaac/_features.py similarity index 97% rename from pyaptamer/pseaac/features.py rename to pyaptamer/pseaac/_features.py index 802f9fb8..b4ea5721 100644 --- a/pyaptamer/pseaac/features.py +++ b/pyaptamer/pseaac/_features.py @@ -1,7 +1,7 @@ import numpy as np -from pyaptamer._utils.pseaac_utils import AMINO_ACIDS, is_valid_aa from pyaptamer.pseaac._props import aa_props +from pyaptamer.utils._pseaac_utils import AMINO_ACIDS, is_valid_aa class PSeAAC: @@ -20,7 +20,7 @@ class PSeAAC: >>> pse = PSeAAC() >>> features = pse.transform("ACDEFGHIKLMNPQRSTVWY") >>> print(features[:10]) - [0.05, 0.05, 0.05, 0.05, 0.05, 0.05, 0.05, 0.05, 0.05, 0.05] + np.array([0.05, 0.05, 0.05, 0.05, 0.05, 0.05, 0.05, 0.05, 0.05, 0.05]) Methods ------- diff --git a/pyaptamer/pseaac/tests/test_pseaac.py b/pyaptamer/pseaac/tests/test_pseaac.py index 93ea150f..6c1b2025 100644 --- a/pyaptamer/pseaac/tests/test_pseaac.py +++ b/pyaptamer/pseaac/tests/test_pseaac.py @@ -1,8 +1,8 @@ import numpy as np import pytest +from pyaptamer.pseaac import PSeAAC from pyaptamer.pseaac._props import aa_props -from pyaptamer.pseaac.features import PSeAAC from pyaptamer.pseaac.tests._props import solution diff --git a/pyaptamer/_utils/pseaac_utils.py b/pyaptamer/utils/_pseaac_utils.py similarity index 100% rename from pyaptamer/_utils/pseaac_utils.py rename to pyaptamer/utils/_pseaac_utils.py From 6ecf5761c7f1f7517c474d11b103007cd9e24a10 Mon Sep 17 00:00:00 2001 From: satvshr Date: Tue, 15 Jul 2025 12:52:35 +0530 Subject: [PATCH 024/145] Made requested changes --- pyaptamer/pseaac/_features.py | 18 ++++++++++++++---- 1 file changed, 14 insertions(+), 4 deletions(-) diff --git a/pyaptamer/pseaac/_features.py b/pyaptamer/pseaac/_features.py index b4ea5721..46f2f057 100644 --- a/pyaptamer/pseaac/_features.py +++ b/pyaptamer/pseaac/_features.py @@ -8,8 +8,17 @@ class PSeAAC: """ Compute Pseudo Amino Acid Composition (PseAAC) features for a protein sequence. - This class generates a feature vector for a given protein sequence using selected - physicochemical properties and sequence-order information. + This class generates a numerical feature vector that encodes both the composition + and local order of amino acids in a protein sequence. The features are derived from + selected physicochemical properties and sequence-order correlations as described in + the PseAAC model by Chou. + + Each feature vector consists of: + - 20 normalized amino acid composition features (frequency of each standard + amino acid) + - 30 sequence-order correlation features based on physicochemical similarity between + residues These 50 features are computed for each of 7 predefined property groups, + resulting in a final vector of length 350. Parameters ---------- @@ -137,8 +146,9 @@ def transform(self, protein_sequence): Returns ------- np.ndarray - A 1D NumPy array of length 50 * len(prop_groups), where each 50-element - block consists of: + A 1D NumPy array of length 50 * len(prop_groups), where len(prop_groups) + is the number of property groups used for feature extraction (default = 7). + Each 50-element block consists of: - 20 normalized amino acid composition features - 30 normalized sequence-order correlation factors (theta values) From b91c511e4d6d8cc8fffdbb71df4ceafaad5bd76a Mon Sep 17 00:00:00 2001 From: satvshr Date: Tue, 15 Jul 2025 16:11:10 +0530 Subject: [PATCH 025/145] Made requested changes --- pyaptamer/pseaac/_features.py | 10 ++++++++-- 1 file changed, 8 insertions(+), 2 deletions(-) diff --git a/pyaptamer/pseaac/_features.py b/pyaptamer/pseaac/_features.py index 46f2f057..18eca4cf 100644 --- a/pyaptamer/pseaac/_features.py +++ b/pyaptamer/pseaac/_features.py @@ -20,6 +20,12 @@ class PSeAAC: residues These 50 features are computed for each of 7 predefined property groups, resulting in a final vector of length 350. + References + ---------- + Shen HB, Chou KC. PseAAC: a flexible web server for generating various kinds of + protein pseudo amino acid composition. Anal Biochem. 2008 Feb 15;373(2):386-8. + doi: 10.1016/j.ab.2007.10.012. Epub 2007 Oct 13. PMID: 17976365. + Parameters ---------- None (see `transform` method for usage) @@ -147,7 +153,7 @@ def transform(self, protein_sequence): ------- np.ndarray A 1D NumPy array of length 50 * len(prop_groups), where len(prop_groups) - is the number of property groups used for feature extraction (default = 7). + is the number of property groups used for feature extraction (7). Each 50-element block consists of: - 20 normalized amino acid composition features - 30 normalized sequence-order correlation factors (theta values) @@ -156,7 +162,7 @@ def transform(self, protein_sequence): ------ ValueError If the sequence contains invalid amino acids or is shorter than - the required lambda value (default = 30). + the required lambda value (30). """ if not is_valid_aa(protein_sequence): raise ValueError( From b2428b00f49641ccea7c760eb1081f434778ee1d Mon Sep 17 00:00:00 2001 From: satvshr Date: Wed, 16 Jul 2025 04:08:44 +0530 Subject: [PATCH 026/145] chore: dummy commit to retrigger CI From 2982954ba1772135e3de71b6002c83fed4558f21 Mon Sep 17 00:00:00 2001 From: satvshr Date: Wed, 16 Jul 2025 04:10:31 +0530 Subject: [PATCH 027/145] Added missing init file to utils --- pyaptamer/utils/__init__.py | 0 1 file changed, 0 insertions(+), 0 deletions(-) create mode 100644 pyaptamer/utils/__init__.py diff --git a/pyaptamer/utils/__init__.py b/pyaptamer/utils/__init__.py new file mode 100644 index 00000000..e69de29b From 0b5b38886f114380953ca85c93b0a4166b513ffd Mon Sep 17 00:00:00 2001 From: satvshr Date: Wed, 16 Jul 2025 21:03:41 +0530 Subject: [PATCH 028/145] Made requested changes --- pyaptamer/pseaac/_features.py | 29 +++++++++++++++++++++++++++-- pyaptamer/utils/__init__.py | 1 + 2 files changed, 28 insertions(+), 2 deletions(-) diff --git a/pyaptamer/pseaac/_features.py b/pyaptamer/pseaac/_features.py index 18eca4cf..0ee439f6 100644 --- a/pyaptamer/pseaac/_features.py +++ b/pyaptamer/pseaac/_features.py @@ -13,6 +13,31 @@ class PSeAAC: selected physicochemical properties and sequence-order correlations as described in the PseAAC model by Chou. + The PSeAAC algorith uses 21 normalized physiochemical (NP) properties of amino + acids, which we load from a predefined matrix using `aa_props`, the properties in + order are: + - Hydrophobicity + - Hydrophilicity + - Side-chain Mass + - Polarity + - Molecular Weight + - Melting Point + - Transfer Free Energy + - Buriability + - Bulkiness + - Solvation Free Energy + - Relative Mutability + - Residue Volume + - Volume + - Amino Acid Distribution + - Hydration Number + - Isoelectric Point + - Compressibility + - Chromatographic Index + - Unfolding Entropy Change + - Unfolding Enthalpy Change + - Unfolding Gibbs Free Energy Change + Each feature vector consists of: - 20 normalized amino acid composition features (frequency of each standard amino acid) @@ -152,8 +177,8 @@ def transform(self, protein_sequence): Returns ------- np.ndarray - A 1D NumPy array of length 50 * len(prop_groups), where len(prop_groups) - is the number of property groups used for feature extraction (7). + A 1D NumPy array of length 50 * number of property groups used for + feature extraction (7). Each 50-element block consists of: - 20 normalized amino acid composition features - 30 normalized sequence-order correlation factors (theta values) diff --git a/pyaptamer/utils/__init__.py b/pyaptamer/utils/__init__.py index e69de29b..4cc89dc5 100644 --- a/pyaptamer/utils/__init__.py +++ b/pyaptamer/utils/__init__.py @@ -0,0 +1 @@ +"""Utils for the pyaptamer package.""" From 0cd72b7df981f6aabe32d0d10c664558c54105e4 Mon Sep 17 00:00:00 2001 From: satvshr Date: Wed, 16 Jul 2025 23:18:05 +0530 Subject: [PATCH 029/145] Added requested changes --- pyaptamer/pseaac/_features.py | 9 +++++---- 1 file changed, 5 insertions(+), 4 deletions(-) diff --git a/pyaptamer/pseaac/_features.py b/pyaptamer/pseaac/_features.py index 0ee439f6..a081040b 100644 --- a/pyaptamer/pseaac/_features.py +++ b/pyaptamer/pseaac/_features.py @@ -42,8 +42,9 @@ class PSeAAC: - 20 normalized amino acid composition features (frequency of each standard amino acid) - 30 sequence-order correlation features based on physicochemical similarity between - residues These 50 features are computed for each of 7 predefined property groups, - resulting in a final vector of length 350. + residues. + - These 50 features are computed for each of 7 predefined property groups, + resulting in a final vector of length 350 ((20 + 30) * 7 = 350). References ---------- @@ -177,8 +178,8 @@ def transform(self, protein_sequence): Returns ------- np.ndarray - A 1D NumPy array of length 50 * number of property groups used for - feature extraction (7). + A 1D NumPy array of length 50 * number of normalized physiochemical (NP) + properties of amino acids (7). Each 50-element block consists of: - 20 normalized amino acid composition features - 30 normalized sequence-order correlation factors (theta values) From fabc7b4e666b32d18cc5a5129f1bb6c7d5164970 Mon Sep 17 00:00:00 2001 From: satvshr Date: Wed, 16 Jul 2025 23:20:57 +0530 Subject: [PATCH 030/145] Added requested changes --- pyaptamer/pseaac/_features.py | 4 ++-- 1 file changed, 2 insertions(+), 2 deletions(-) diff --git a/pyaptamer/pseaac/_features.py b/pyaptamer/pseaac/_features.py index a081040b..fc096874 100644 --- a/pyaptamer/pseaac/_features.py +++ b/pyaptamer/pseaac/_features.py @@ -71,7 +71,7 @@ class PSeAAC: def __init__(self): """ - Initialize PSeAAC with a protein sequence. + Initialize PSeAAC. """ # Load normalized property matrix (20x21, rows=AA, cols=NP1-NP21) @@ -179,7 +179,7 @@ def transform(self, protein_sequence): ------- np.ndarray A 1D NumPy array of length 50 * number of normalized physiochemical (NP) - properties of amino acids (7). + property groups of amino acids (7). Each 50-element block consists of: - 20 normalized amino acid composition features - 30 normalized sequence-order correlation factors (theta values) From 32633d38c34b17065e6ed95b881391ac7cad445b Mon Sep 17 00:00:00 2001 From: satvshr Date: Thu, 17 Jul 2025 01:06:51 +0530 Subject: [PATCH 031/145] Added info about prop groups in class docstring --- pyaptamer/pseaac/_features.py | 7 +++++-- 1 file changed, 5 insertions(+), 2 deletions(-) diff --git a/pyaptamer/pseaac/_features.py b/pyaptamer/pseaac/_features.py index fc096874..beaff624 100644 --- a/pyaptamer/pseaac/_features.py +++ b/pyaptamer/pseaac/_features.py @@ -14,8 +14,11 @@ class PSeAAC: the PseAAC model by Chou. The PSeAAC algorith uses 21 normalized physiochemical (NP) properties of amino - acids, which we load from a predefined matrix using `aa_props`, the properties in - order are: + acids, which we load from a predefined matrix using `aa_props`.These 21 properties + are grouped into 7 distinct property groups, with each group containing + 3 consecutive properties. Specifically, the groups are arranged in order as follows: + Group 1 includes properties 1–3, Group 2 includes properties 4–6, and so on, up to + Group 7, which includes properties 19–21. the properties in order are: - Hydrophobicity - Hydrophilicity - Side-chain Mass From 056c08ea890932e5854f858715b44f7096e4d241 Mon Sep 17 00:00:00 2001 From: satvshr Date: Thu, 17 Jul 2025 23:14:44 +0530 Subject: [PATCH 032/145] Merged issue28 to issue13 --- pyaptamer/AptaNet/aptanet.py | 109 ------------- pyaptamer/AptaNet/neural_net.py | 198 ------------------------ pyaptamer/aptanet/__init__.py | 5 + pyaptamer/aptanet/_model.py | 249 ++++++++++++++++++++++++++++++ pyaptamer/utils/_aptanet_utils.py | 51 ++++++ 5 files changed, 305 insertions(+), 307 deletions(-) delete mode 100644 pyaptamer/AptaNet/aptanet.py delete mode 100644 pyaptamer/AptaNet/neural_net.py create mode 100644 pyaptamer/aptanet/__init__.py create mode 100644 pyaptamer/aptanet/_model.py create mode 100644 pyaptamer/utils/_aptanet_utils.py diff --git a/pyaptamer/AptaNet/aptanet.py b/pyaptamer/AptaNet/aptanet.py deleted file mode 100644 index cb59d346..00000000 --- a/pyaptamer/AptaNet/aptanet.py +++ /dev/null @@ -1,109 +0,0 @@ -from AptaNet.pseaac import pseaac - - -class AptaNet: - """ - AptaNet feature generator for aptamer-protein pairs. - - This class generates a combined feature vector using k-mer frequencies from the aptamer DNA sequence - and PseAAC features from the protein sequence. - - Parameters - ---------- - aptamer_sequence : str - The DNA sequence of the aptamer. - protein_sequence : str - The protein sequence to be analyzed. - - Attributes - ---------- - aptamer_sequence : str - The DNA sequence of the aptamer. - protein_sequence : str - The protein sequence to be analyzed. - amino_acid : list of str - List of 20 native amino acids in alphabetical order. - pseaac : pseaac - PseAAC object for the protein sequence. - """ - - def __init__(self, aptamer_sequence, protein_sequence): - """ - Initialize the AptaNet class with an aptamer sequence and a protein sequence. - - Parameters - ---------- - aptamer_sequence : str - The DNA sequence of the aptamer. - protein_sequence : str - The protein sequence to be analyzed. - """ - self.aptamer_sequence = aptamer_sequence - self.protein_sequence = protein_sequence - - # Define the 20 native amino acids according to the alphabetical order of their single-letter codes - self.amino_acid = list("ACDEFGHIKLMNPQRSTVWY") - - # Initialize the PseAAC object with the protein sequence - self.pseaac = pseaac(self, self.protein_sequence) - - def _generate_kmer_vecs(self, aptamer_sequence, k=4): - """ - Generate normalized k-mer frequency vectors for the aptamer sequence. - - For all possible k-mers from length 1 to k, count their occurrences in the sequence - and normalize to form a frequency vector. - - Parameters - ---------- - aptamer_sequence : str - The DNA sequence of the aptamer. - k : int, optional - Maximum k-mer length (default is 4). - - Returns - ------- - list of float - Normalized frequency vector for all possible k-mers from length 1 to k. - """ - from itertools import product - - bases = ["A", "C", "G", "T"] - - # Generate all possible k-mers from 1 to k - all_kmers = [] - for i in range(1, k + 1): - all_kmers.extend(["".join(p) for p in product(bases, repeat=i)]) - - # Count occurrences of each k-mer in the aptamer_sequence - kmer_counts = {kmer: 0 for kmer in all_kmers} - for i in range(len(aptamer_sequence)): - for j in range(1, k + 1): - if i + j <= len(aptamer_sequence): - kmer = aptamer_sequence[i : i + j] - if kmer in kmer_counts: - kmer_counts[kmer] += 1 - - # Normalize counts to frequencies - total_kmers = sum(kmer_counts.values()) - kmer_freq = [ - kmer_counts[kmer] / total_kmers if total_kmers > 0 else 0 - for kmer in all_kmers - ] - - return kmer_freq - - def generate_final_vector(self): - """ - Generate the final feature vector by concatenating k-mer and PseAAC features. - - Returns - ------- - list of float - Combined feature vector for the aptamer-protein pair. - """ - final_vector = ( - self._generate_kmer_vecs(self.aptamer_sequence, k=4) + self.pseaac - ) - - return final_vector diff --git a/pyaptamer/AptaNet/neural_net.py b/pyaptamer/AptaNet/neural_net.py deleted file mode 100644 index f43437a3..00000000 --- a/pyaptamer/AptaNet/neural_net.py +++ /dev/null @@ -1,198 +0,0 @@ -import torch -import torch.nn as nn -import torch.optim as optim -import torch.nn.functional as F -from sklearn.ensemble import RandomForestClassifier -from sklearn.feature_selection import SelectFromModel - - -class MLP(nn.Module): - """ - Multi-layer Perceptron (MLP) for binary classification with feature selection. - - This model uses a RandomForest-based feature selector and a deep neural network - with AlphaDropout for robust training. - - Parameters - ---------- - input_dim : int, optional - Number of input features before feature selection (default is 639). - - Attributes - ---------- - clf : RandomForestClassifier - Random forest used for feature selection. - clf_model : SelectFromModel or None - Feature selector model after fitting. - criterion : nn.BCELoss - Binary cross-entropy loss function. - optimizer : torch.optim.Optimizer or None - Optimizer for training. - """ - - def __init__(self, input_dim=639): - """ - Initialize the MLP model. - - Parameters - ---------- - input_dim : int, optional - Number of input features before feature selection (default is 639). - """ - super(MLP, self).__init__() - - self.input_dim = input_dim - - self.fc1 = nn.Linear(input_dim, 128) - self.dropout1 = nn.AlphaDropout(0.3) - self.fc2 = nn.Linear(128, 128) - self.dropout2 = nn.AlphaDropout(0.3) - self.fc3 = nn.Linear(128, 128) - self.dropout3 = nn.AlphaDropout(0.3) - self.fc4 = nn.Linear(128, 128) - self.dropout4 = nn.AlphaDropout(0.3) - self.fc5 = nn.Linear(128, 128) - self.dropout5 = nn.AlphaDropout(0.3) - self.fc6 = nn.Linear(128, 128) - self.dropout6 = nn.AlphaDropout(0.3) - self.fc7 = nn.Linear(128, 1) # Binary classification - - self.criterion = nn.BCELoss() - self.optimizer = None - - # Random forest feature selector - self.clf = RandomForestClassifier(n_estimators=300, max_depth=9, random_state=0) - self.clf_model = None - - def _forward(self, x): - """ - Forward pass through the network. - - Parameters - ---------- - x : torch.Tensor - Input tensor of shape (batch_size, n_features). - - Returns - ------- - torch.Tensor - Output tensor with predicted probabilities. - """ - x = F.relu(self.fc1(x)) - x = self.dropout1(x) - x = F.relu(self.fc2(x)) - x = self.dropout2(x) - x = F.relu(self.fc3(x)) - x = self.dropout3(x) - x = F.relu(self.fc4(x)) - x = self.dropout4(x) - x = F.relu(self.fc5(x)) - x = self.dropout5(x) - x = F.relu(self.fc6(x)) - x = self.dropout6(x) - x = torch.sigmoid(self.fc7(x)) - return x - - def _train_clf_model(self, X, y): - """ - Train the random forest feature selector. - - Parameters - ---------- - X : array-like of shape (n_samples, n_features) - Training input samples. - y : array-like of shape (n_samples,) - Target values. - - Returns - ------- - SelectFromModel - Trained feature selector. - """ - self.clf.fit(X, y) - self.clf_model = SelectFromModel(self.clf, prefit=True) - return self.clf_model - - def _transform_X(self, X): - """ - Transform input features using the trained feature selector. - - Parameters - ---------- - X : array-like of shape (n_samples, n_features) - Input samples. - - Returns - ------- - array-like - Transformed input samples with selected features. - - Raises - ------ - ValueError - If the feature selector has not been trained. - """ - if self.clf_model is None: - raise ValueError("Classifier model has not been trained yet.") - return self.clf_model.transform(X) - - def fit(self, X, y, epochs=200, batch_size=310): - """ - Fit the MLP model to the training data. - - Parameters - ---------- - X : array-like of shape (n_samples, n_features) - Training input samples. - y : array-like of shape (n_samples,) - Target values. - epochs : int, optional - Number of training epochs (default is 200). - batch_size : int, optional - Batch size for training (default is 310). - """ - # Convert to PyTorch tensors - self.clf_model = self._train_clf_model(X, y) - X_transformed = self._transform_X(X) - X_tensor = torch.tensor(X_transformed, dtype=torch.float32) - y_tensor = torch.tensor(y, dtype=torch.float32).unsqueeze(1) - - self.optimizer = optim.RMSprop( - self.parameters(), lr=0.00014, alpha=0.9, eps=1e-07 - ) - - dataset = torch.utils.data.TensorDataset(X_tensor, y_tensor) - dataloader = torch.utils.data.DataLoader( - dataset, batch_size=batch_size, shuffle=True - ) - - self.train() - for epoch in range(epochs): - for batch_x, batch_y in dataloader: - self.optimizer.zero_grad() - output = self._forward(batch_x) - loss = self.criterion(output, batch_y) - loss.backward() - self.optimizer.step() - - def predict(self, X): - """ - Predict binary class labels for input samples. - - Parameters - ---------- - X : array-like of shape (n_samples, n_features) - Input samples. - - Returns - ------- - numpy.ndarray - Predicted class labels (0 or 1). - """ - self.eval() - X_transformed = self.transform_X(X) - X_tensor = torch.tensor(X_transformed, dtype=torch.float32) - with torch.no_grad(): - output = self._forward(X_tensor) - predictions = (output > 0.5).int().squeeze().numpy() - return predictions diff --git a/pyaptamer/aptanet/__init__.py b/pyaptamer/aptanet/__init__.py new file mode 100644 index 00000000..272dd409 --- /dev/null +++ b/pyaptamer/aptanet/__init__.py @@ -0,0 +1,5 @@ +"""The AptaNet algorithm""" + +from pyaptamer.aptanet._model import AptaNet + +__all__ = ["AptaNet"] diff --git a/pyaptamer/aptanet/_model.py b/pyaptamer/aptanet/_model.py new file mode 100644 index 00000000..a41f3ff1 --- /dev/null +++ b/pyaptamer/aptanet/_model.py @@ -0,0 +1,249 @@ +import numpy as np +import torch +import torch.nn as nn +import torch.optim as optim +from sklearn.ensemble import RandomForestClassifier +from sklearn.feature_selection import SelectFromModel + +from pyaptamer.pseaac import PSeAAC +from pyaptamer.utils._aptanet_utils import generate_kmer_vecs + + +def aptanet_layer(input_dim: int, output_dim: int, dropout: float) -> nn.Sequential: + """Create a single AptaNet layer with AlphaDropout and ReLU activation.""" + return nn.Sequential( + nn.Linear(input_dim, output_dim), + nn.ReLU(), + nn.AlphaDropout(dropout), + ) + + +class AptaNet(nn.Module): + """ + AptaNet deep neural network for classification and feature generation. + + This class generates a combined feature vector using k-mer frequencies from the + aptamer DNA sequence and PseAAC features from the protein sequence, and provides + a deep neural network to classify binding interactions between aptamers and + proteins, with a binary output (0 or 1). + + References + ---------- + Emami, N., Ferdousi, R. AptaNet as a deep learning approach for aptamer–protein + interaction prediction. Sci Rep 11, 6074 (2021). + + Parameters + ---------- + n_layers : int + Number of hidden layers. + hidden_dim : int + Hidden layer dimension. + output_dim : int + Output feature dimension. + dropout : float + Dropout rate for AlphaDropout. + + Example + -------- + >>> aptanet = AptaNet(n_layers=5, hidden_dim=128, dropout=0.3) + >>> aptanet.fit(X_train, y_train, epochs=100, batch_size=32) + >>> predictions = aptanet.predict(X_test) + >>> feature_vector = aptanet.preprocessing(aptamer_sequence, protein_sequence) + >>> print(feature_vector[:10]) + np.array([0.05, 0.05, 0.05, 0.05, 0.05, 0.05, 0.05, 0.05, 0.05, 0.05]) + + Methods + ---------- + forward(X) + Forward pass through the network. + fit(X, y, epochs, batch_size) + Fit the AptaNet model to the training data. + predict(X) + Predict binary class labels for input samples. + preprocessing(aptamer_sequence, protein_sequence) + Generate the final feature vector by concatenating k-mer and PseAAC features. + """ + + def __init__( + self, + n_layers=7, + hidden_dim=128, + dropout=0.3, + output_dim=1, + ): + super().__init__() + assert n_layers > 0, "Number of hidden layers must be greater than 0." + + self.input_dim = None # Will be set after feature selection + self.output_dim = output_dim # Binary classification + self.hidden_dim = hidden_dim + self.n_layers = n_layers + self.dropout = dropout + self.criterion = nn.BCEWithLogitsLoss() + # Optimizer will be initialized during training (lack of self.parameters()) + self.optimizer = None + self.clf = RandomForestClassifier( + n_estimators=300, max_depth=9, random_state=0 + ) # Random forest feature selector + self.clf_model = None # Feature selector model after fitting + self.model = None # Will be initialized after feature selection + + def _init_model(self, input_dim): + """Initialize AptaNet's deep neural network after feature selection.""" + model = [aptanet_layer(input_dim, self.hidden_dim, self.dropout)] + for _ in range(self.n_layers): + model.append(aptanet_layer(self.hidden_dim, self.hidden_dim, self.dropout)) + model.append(nn.Linear(self.hidden_dim, self.output_dim)) + return nn.Sequential(*model) + + def forward(self, X): + """ + Forward pass through the network. + + Parameters + ---------- + X : torch.Tensor + Input tensor of shape (batch_size, n_features). + + Returns + ------- + torch.Tensor + Output tensor with predicted probabilities. + """ + return self.model(X) + + def _train_clf_model(self, X, y): + """ + Train the random forest feature selector. + + Parameters + ---------- + X : array-like of shape (n_samples, n_features) + Training input samples. + y : array-like of shape (n_samples,) + Target values. + + Returns + ------- + SelectFromModel + Trained feature selector. + """ + self.clf.fit(X, y) + self.clf_model = SelectFromModel(self.clf, prefit=True) + return self.clf_model + + def _transform_x(self, X): + """ + Transform input features using the trained feature selector. + + Parameters + ---------- + X : array-like of shape (n_samples, n_features) + Input samples. + + Returns + ------- + array-like + Transformed input samples with selected features. + + Raises + ------ + ValueError + If the feature selector has not been trained. + """ + if self.clf_model is None: + raise ValueError("Classifier model has not been trained yet.") + return self.clf_model.transform(X) + + def fit(self, X, y, epochs=200, batch_size=310): + """ + Fit the AptaNet model to the training data. + + Parameters + ---------- + X : array-like of shape (n_samples, n_features) + Training input samples. + y : array-like of shape (n_samples,) + Target values. + epochs : int, optional + Number of training epochs (default is 200). + batch_size : int, optional + Batch size for training (default is 310). + """ + # Feature selection + self.clf_model = self._train_clf_model(X, y) + X_transformed = self._transform_x(X) + self.input_dim = X_transformed.shape[1] + # Initialize the model with the selected input dimension + self.model = self._init_model(self.input_dim) + X_tensor = torch.tensor(X_transformed, dtype=torch.float32) + y_tensor = torch.tensor(y, dtype=torch.float32).unsqueeze(1) + + self.optimizer = optim.RMSprop( + self.parameters(), lr=0.00014, alpha=0.9, eps=1e-07 + ) + + dataset = torch.utils.data.TensorDataset(X_tensor, y_tensor) + dataloader = torch.utils.data.DataLoader( + dataset, batch_size=batch_size, shuffle=True + ) + + self.train() + for _epoch in range(epochs): + for batch_x, batch_y in dataloader: + self.optimizer.zero_grad() + output = self(batch_x) + loss = self.criterion(output, batch_y) + loss.backward() + self.optimizer.step() + + def predict(self, X): + """ + Predict binary class labels for input samples. + + Parameters + ---------- + X : array-like of shape (n_samples, n_features) + Input samples. + + Returns + ------- + numpy.ndarray + Predicted class labels (0 or 1). + """ + self.eval() + X_transformed = self._transform_x(X) + X_tensor = torch.tensor(X_transformed, dtype=torch.float32) + with torch.no_grad(): + logits = self(X_tensor) + probs = torch.sigmoid(logits) + predictions = (probs > 0.5).int().squeeze().numpy() + return predictions + + def preprocessing(self, aptamer_sequence, protein_sequence): + """ + Generate the final feature vector by concatenating k-mer and PseAAC features. + + Parameters + ---------- + aptamer_sequence : str + The DNA sequence of the aptamer. + protein_sequence : str + The protein sequence to be analyzed. + + Returns + ------- + np.ndarray + 1D numpy array of combined feature vector for the aptamer-protein pair. + """ + self.aptamer_sequence = aptamer_sequence + self.protein_sequence = protein_sequence + + # Initialize the PseAAC object with the protein sequence + self.pseaac = PSeAAC.transform(self.protein_sequence) + + final_vector = np.concatenate( + [generate_kmer_vecs(self.aptamer_sequence, k=4), np.array(self.pseaac)] + ) + + return final_vector diff --git a/pyaptamer/utils/_aptanet_utils.py b/pyaptamer/utils/_aptanet_utils.py new file mode 100644 index 00000000..ea4bbe9f --- /dev/null +++ b/pyaptamer/utils/_aptanet_utils.py @@ -0,0 +1,51 @@ +DNA_BASES = list("ACGT") + + +def generate_kmer_vecs(aptamer_sequence, k=4): + """ + Generate normalized k-mer frequency vectors for the aptamer sequence. + + For all possible k-mers from length 1 to k, count their occurrences in the sequence + and normalize to form a frequency vector. + + Parameters + ---------- + aptamer_sequence : str + The DNA sequence of the aptamer. + k : int, optional + Maximum k-mer length (default is 4). + + Returns + ------- + np.ndarray + 1D numpy array of normalized frequency vector for all possible k-mers from + length 1 to k. + """ + from itertools import product + + import numpy as np + + # Generate all possible k-mers from 1 to k + all_kmers = [] + for i in range(1, k + 1): + all_kmers.extend(["".join(p) for p in product(DNA_BASES, repeat=i)]) + + # Count occurrences of each k-mer in the aptamer_sequence + kmer_counts = dict.fromkeys(all_kmers, 0) + for i in range(len(aptamer_sequence)): + for j in range(1, k + 1): + if i + j <= len(aptamer_sequence): + kmer = aptamer_sequence[i : i + j] + if kmer in kmer_counts: + kmer_counts[kmer] += 1 + + # Normalize counts to frequencies + total_kmers = sum(kmer_counts.values()) + kmer_freq = np.array( + [ + kmer_counts[kmer] / total_kmers if total_kmers > 0 else 0 + for kmer in all_kmers + ] + ) + + return kmer_freq From 6136c39a8cb02e6c79f59134f35e94082e260071 Mon Sep 17 00:00:00 2001 From: satvshr Date: Thu, 17 Jul 2025 23:15:43 +0530 Subject: [PATCH 033/145] Removed init method description --- pyaptamer/pseaac/_features.py | 4 ---- 1 file changed, 4 deletions(-) diff --git a/pyaptamer/pseaac/_features.py b/pyaptamer/pseaac/_features.py index beaff624..dcff892f 100644 --- a/pyaptamer/pseaac/_features.py +++ b/pyaptamer/pseaac/_features.py @@ -73,10 +73,6 @@ class PSeAAC: """ def __init__(self): - """ - Initialize PSeAAC. - """ - # Load normalized property matrix (20x21, rows=AA, cols=NP1-NP21) self.np_matrix = aa_props(type="numpy", normalize=True) # Each prop_group is a tuple of 3 columns (property indices) From ae7d1feb6ccbebf506f29d8dfe9a0766386149eb Mon Sep 17 00:00:00 2001 From: satvshr Date: Thu, 17 Jul 2025 23:16:46 +0530 Subject: [PATCH 034/145] Removed init method description --- pyaptamer/pseaac/_features.py | 4 ---- 1 file changed, 4 deletions(-) diff --git a/pyaptamer/pseaac/_features.py b/pyaptamer/pseaac/_features.py index beaff624..dcff892f 100644 --- a/pyaptamer/pseaac/_features.py +++ b/pyaptamer/pseaac/_features.py @@ -73,10 +73,6 @@ class PSeAAC: """ def __init__(self): - """ - Initialize PSeAAC. - """ - # Load normalized property matrix (20x21, rows=AA, cols=NP1-NP21) self.np_matrix = aa_props(type="numpy", normalize=True) # Each prop_group is a tuple of 3 columns (property indices) From f339a7b8d6f34b0492cc1b907d99cf49eb95de7f Mon Sep 17 00:00:00 2001 From: satvshr Date: Fri, 18 Jul 2025 01:02:53 +0530 Subject: [PATCH 035/145] Added tests and bug fixes --- .vscode/settings.json | 14 ++++++++ pyaptamer/aptanet/_model.py | 9 +++-- pyaptamer/aptanet/tests/__init__.py | 1 + pyaptamer/aptanet/tests/test_aptanet.py | 48 +++++++++++++++++++++++++ 4 files changed, 69 insertions(+), 3 deletions(-) create mode 100644 .vscode/settings.json create mode 100644 pyaptamer/aptanet/tests/__init__.py create mode 100644 pyaptamer/aptanet/tests/test_aptanet.py diff --git a/.vscode/settings.json b/.vscode/settings.json new file mode 100644 index 00000000..5e318df4 --- /dev/null +++ b/.vscode/settings.json @@ -0,0 +1,14 @@ +{ + "python.testing.pytestArgs": [ + "pyaptamer" + ], + "python.testing.unittestEnabled": true, + "python.testing.pytestEnabled": false, + "python.testing.unittestArgs": [ + "-v", + "-s", + "./pyaptamer", + "-p", + "test_*.py" + ] +} \ No newline at end of file diff --git a/pyaptamer/aptanet/_model.py b/pyaptamer/aptanet/_model.py index a41f3ff1..98e3357e 100644 --- a/pyaptamer/aptanet/_model.py +++ b/pyaptamer/aptanet/_model.py @@ -239,11 +239,14 @@ def preprocessing(self, aptamer_sequence, protein_sequence): self.aptamer_sequence = aptamer_sequence self.protein_sequence = protein_sequence - # Initialize the PseAAC object with the protein sequence - self.pseaac = PSeAAC.transform(self.protein_sequence) + self.pseaac = PSeAAC() + self.pseaac_sequence = self.pseaac.transform(protein_sequence) final_vector = np.concatenate( - [generate_kmer_vecs(self.aptamer_sequence, k=4), np.array(self.pseaac)] + [ + generate_kmer_vecs(self.aptamer_sequence, k=4), + np.array(self.pseaac_sequence), + ] ) return final_vector diff --git a/pyaptamer/aptanet/tests/__init__.py b/pyaptamer/aptanet/tests/__init__.py new file mode 100644 index 00000000..8c1bcfd3 --- /dev/null +++ b/pyaptamer/aptanet/tests/__init__.py @@ -0,0 +1 @@ +"""Tests for the AptaNet model""" diff --git a/pyaptamer/aptanet/tests/test_aptanet.py b/pyaptamer/aptanet/tests/test_aptanet.py new file mode 100644 index 00000000..a3b4585e --- /dev/null +++ b/pyaptamer/aptanet/tests/test_aptanet.py @@ -0,0 +1,48 @@ +import numpy as np +import pytest + +from pyaptamer.aptanet import AptaNet +from pyaptamer.pseaac import PSeAAC + + +@pytest.mark.parametrize( + "aptamer_seq, protein_seq", + [ + ( + "ACDEFGHIKLMNPQRSTVWYACDEFGHIKLMNPQRSTVWY", + "AGCTTAGCGTACAGCTTAGCGTAC", + ) + ], +) +def test_model_fit_and_predict(aptamer_seq, protein_seq): + """ + Test AptaNet fitting and predicting on synthetic data. + + Asserts + ------- + Model predictions are valid class labels and shape matches input. + """ + model = AptaNet(n_layers=3, hidden_dim=64, dropout=0.2) + + # Generate dummy feature matrix + X = np.array([model.preprocessing(aptamer_seq, protein_seq) for _ in range(40)]) + y = np.array([0] * 20 + [1] * 20) + + model.fit(X, y, epochs=5, batch_size=10) + + preds = model.predict(X) + assert preds.shape == (40,) + assert set(preds).issubset({0, 1}) + + +def test_invalid_protein_sequence(): + """ + Test PSeAAC raises ValueError on invalid amino acids. + + Asserts + ------- + ValueError is raised for an invalid protein sequence. + """ + pseaac = PSeAAC() + with pytest.raises(ValueError): + pseaac.transform("ACDEXFGHIKL") # 'X' is not a valid amino acid From 651d066524e2f9dcf1f0f46a050f503ab6fcf03f Mon Sep 17 00:00:00 2001 From: satvshr Date: Fri, 18 Jul 2025 01:07:17 +0530 Subject: [PATCH 036/145] Added torch as a dependency --- pyproject.toml | 1 + 1 file changed, 1 insertion(+) diff --git a/pyproject.toml b/pyproject.toml index d5e878b5..97bedab4 100644 --- a/pyproject.toml +++ b/pyproject.toml @@ -21,6 +21,7 @@ dependencies = [ dev = [ "ruff>=0.12.0", "pytest>=8.0.0", + ""torch>=2.0.0", "pre-commit" ] From 7991cc8660f7d1087c06a4006754453e2a1321fc Mon Sep 17 00:00:00 2001 From: satvshr Date: Fri, 18 Jul 2025 01:08:46 +0530 Subject: [PATCH 037/145] Added torch as a dependency --- pyproject.toml | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/pyproject.toml b/pyproject.toml index 97bedab4..0c1d58ba 100644 --- a/pyproject.toml +++ b/pyproject.toml @@ -21,7 +21,7 @@ dependencies = [ dev = [ "ruff>=0.12.0", "pytest>=8.0.0", - ""torch>=2.0.0", + "torch>=2.0.0", "pre-commit" ] From 8f0f0ae9d1c09cae829791a2fd49cbe53ca14ee7 Mon Sep 17 00:00:00 2001 From: satvshr Date: Fri, 18 Jul 2025 01:18:09 +0530 Subject: [PATCH 038/145] Added sklearn as a dependency --- pyproject.toml | 1 + 1 file changed, 1 insertion(+) diff --git a/pyproject.toml b/pyproject.toml index 0c1d58ba..f5278a1c 100644 --- a/pyproject.toml +++ b/pyproject.toml @@ -22,6 +22,7 @@ dev = [ "ruff>=0.12.0", "pytest>=8.0.0", "torch>=2.0.0", + "scikit-learn>=1.3.0", "pre-commit" ] From 60ec8daa59dd042d83e676c2824ab993ff83d38f Mon Sep 17 00:00:00 2001 From: satvshr Date: Fri, 18 Jul 2025 01:22:23 +0530 Subject: [PATCH 039/145] fixed test so that protein_seq length is above 30 --- pyaptamer/aptanet/tests/test_aptanet.py | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/pyaptamer/aptanet/tests/test_aptanet.py b/pyaptamer/aptanet/tests/test_aptanet.py index a3b4585e..241364da 100644 --- a/pyaptamer/aptanet/tests/test_aptanet.py +++ b/pyaptamer/aptanet/tests/test_aptanet.py @@ -10,7 +10,7 @@ [ ( "ACDEFGHIKLMNPQRSTVWYACDEFGHIKLMNPQRSTVWY", - "AGCTTAGCGTACAGCTTAGCGTAC", + "AGCTTAGCGTACAGCTTAAAAGGGTTTCCCCTGCCCGCGTAC", ) ], ) From 88c0122a60fafd9801d165e23e7dad446808b2d5 Mon Sep 17 00:00:00 2001 From: satvshr Date: Fri, 18 Jul 2025 01:24:55 +0530 Subject: [PATCH 040/145] editing changes --- pyaptamer/pseaac/_features.py | 2 +- pyaptamer/pseaac/tests/test_pseaac.py | 4 ++-- 2 files changed, 3 insertions(+), 3 deletions(-) diff --git a/pyaptamer/pseaac/_features.py b/pyaptamer/pseaac/_features.py index dcff892f..2544b3a4 100644 --- a/pyaptamer/pseaac/_features.py +++ b/pyaptamer/pseaac/_features.py @@ -202,7 +202,7 @@ def transform(self, protein_sequence): seq_len = len(protein_sequence) if seq_len <= lambda_val: raise ValueError( - f"Sequence too short for Lambda={lambda_val}. Must be > {lambda_val}." + f"Protein sequence too short for {lambda_val}. Must be > {lambda_val}." ) for prop_group in self.prop_groups: diff --git a/pyaptamer/pseaac/tests/test_pseaac.py b/pyaptamer/pseaac/tests/test_pseaac.py index 6c1b2025..dec2aa12 100644 --- a/pyaptamer/pseaac/tests/test_pseaac.py +++ b/pyaptamer/pseaac/tests/test_pseaac.py @@ -56,8 +56,8 @@ def test_pseaac_vectorization(seq, expected_vector): Asserts ------- - The produced vector matches the expected vector in - length and values (within tolerance). + The produced vector matches the expected vector in length and + values (within tolerance). """ p = PSeAAC() pv = p.transform(seq) From b7a7349ac6b269bf30030ed31c085b9d357ad6ff Mon Sep 17 00:00:00 2001 From: satvshr Date: Sat, 19 Jul 2025 00:42:16 +0530 Subject: [PATCH 041/145] Made requested changes --- pyaptamer/pseaac/_features.py | 50 +++++++++++++++++++---------------- 1 file changed, 27 insertions(+), 23 deletions(-) diff --git a/pyaptamer/pseaac/_features.py b/pyaptamer/pseaac/_features.py index 2544b3a4..4e7bd01b 100644 --- a/pyaptamer/pseaac/_features.py +++ b/pyaptamer/pseaac/_features.py @@ -18,35 +18,39 @@ class PSeAAC: are grouped into 7 distinct property groups, with each group containing 3 consecutive properties. Specifically, the groups are arranged in order as follows: Group 1 includes properties 1–3, Group 2 includes properties 4–6, and so on, up to - Group 7, which includes properties 19–21. the properties in order are: - - Hydrophobicity - - Hydrophilicity - - Side-chain Mass - - Polarity - - Molecular Weight - - Melting Point - - Transfer Free Energy - - Buriability - - Bulkiness - - Solvation Free Energy - - Relative Mutability - - Residue Volume - - Volume - - Amino Acid Distribution - - Hydration Number - - Isoelectric Point - - Compressibility - - Chromatographic Index - - Unfolding Entropy Change - - Unfolding Enthalpy Change - - Unfolding Gibbs Free Energy Change + Group 7, which includes properties 19–21. + + + The properties in order are: + 1. Hydrophobicity + 2. Hydrophilicity + 3. Side-chain Mass + 4. Polarity + 5. Molecular Weight + 6. Melting Point + 7. Transfer Free Energy + 8. Buriability + 9. Bulkiness + 10. Solvation Free Energy + 11. Relative Mutability + 12. Residue Volume + 13. Volume + 14. Amino Acid Distribution + 15. Hydration Number + 16. Isoelectric Point + 17. Compressibility + 18. Chromatographic Index + 19. Unfolding Entropy Change + 20. Unfolding Enthalpy Change + 21. Unfolding Gibbs Free Energy Change + Each feature vector consists of: - 20 normalized amino acid composition features (frequency of each standard amino acid) - 30 sequence-order correlation features based on physicochemical similarity between residues. - - These 50 features are computed for each of 7 predefined property groups, + These 50 features are computed for each of 7 predefined property groups, resulting in a final vector of length 350 ((20 + 30) * 7 = 350). References From c14c0bb6da5d3a017b2a22991a1c7ced41cfa505 Mon Sep 17 00:00:00 2001 From: satvshr Date: Sat, 19 Jul 2025 00:44:58 +0530 Subject: [PATCH 042/145] Made requested changes --- pyaptamer/pseaac/_features.py | 6 ++++-- 1 file changed, 4 insertions(+), 2 deletions(-) diff --git a/pyaptamer/pseaac/_features.py b/pyaptamer/pseaac/_features.py index 4e7bd01b..1b36ce8b 100644 --- a/pyaptamer/pseaac/_features.py +++ b/pyaptamer/pseaac/_features.py @@ -18,10 +18,9 @@ class PSeAAC: are grouped into 7 distinct property groups, with each group containing 3 consecutive properties. Specifically, the groups are arranged in order as follows: Group 1 includes properties 1–3, Group 2 includes properties 4–6, and so on, up to - Group 7, which includes properties 19–21. + Group 7, which includes properties 19–21. The properties in order are: - The properties in order are: 1. Hydrophobicity 2. Hydrophilicity 3. Side-chain Mass @@ -46,6 +45,8 @@ class PSeAAC: Each feature vector consists of: + + - 20 normalized amino acid composition features (frequency of each standard amino acid) - 30 sequence-order correlation features based on physicochemical similarity between @@ -53,6 +54,7 @@ class PSeAAC: These 50 features are computed for each of 7 predefined property groups, resulting in a final vector of length 350 ((20 + 30) * 7 = 350). + References ---------- Shen HB, Chou KC. PseAAC: a flexible web server for generating various kinds of From d1075a7d7e70642969bb877b8b2fe0a0f4742378 Mon Sep 17 00:00:00 2001 From: satvshr Date: Tue, 22 Jul 2025 13:41:26 +0530 Subject: [PATCH 043/145] Added .vscode to .gitignore --- .gitignore | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/.gitignore b/.gitignore index 7b004e51..172c9637 100644 --- a/.gitignore +++ b/.gitignore @@ -178,7 +178,7 @@ cython_debug/ # that can be found at https://github.com/github/gitignore/blob/main/Global/VisualStudioCode.gitignore # and can be added to the global gitignore or merged into this file. However, if you prefer, # you could uncomment the following to ignore the enitre vscode folder -# .vscode/ +.vscode/ # Ruff stuff: .ruff_cache/ From 19a9e98f1514259142d394eb25f1ce5f9533890d Mon Sep 17 00:00:00 2001 From: satvshr Date: Wed, 23 Jul 2025 01:09:24 +0530 Subject: [PATCH 044/145] Added metadata --- pyaptamer/pseaac/_features.py | 3 +++ 1 file changed, 3 insertions(+) diff --git a/pyaptamer/pseaac/_features.py b/pyaptamer/pseaac/_features.py index 1b36ce8b..7fe56356 100644 --- a/pyaptamer/pseaac/_features.py +++ b/pyaptamer/pseaac/_features.py @@ -1,3 +1,6 @@ +__author__ = "satvshr" +__all__ = ["PSeAAC"] + import numpy as np from pyaptamer.pseaac._props import aa_props From 3c1fa3a12f349917c0d13f64cc7e9d4de9a1037e Mon Sep 17 00:00:00 2001 From: satvshr Date: Thu, 24 Jul 2025 01:12:10 +0530 Subject: [PATCH 045/145] Added architectural changes --- pyaptamer/aptanet/__init__.py | 4 -- pyaptamer/aptanet/_model.py | 25 ++++++++++- pyaptamer/aptanet/aptanet_nn.py | 51 ++++++++++++++++++++++ pyaptamer/aptanet/feature_selector.py | 57 +++++++++++++++++++++++++ pyaptamer/aptanet/pipeline.py | 39 +++++++++++++++++ pyaptamer/aptanet/skorch.py | 14 ++++++ pyaptamer/aptanet/tests/test_aptanet.py | 10 +++++ 7 files changed, 194 insertions(+), 6 deletions(-) create mode 100644 pyaptamer/aptanet/aptanet_nn.py create mode 100644 pyaptamer/aptanet/feature_selector.py create mode 100644 pyaptamer/aptanet/pipeline.py create mode 100644 pyaptamer/aptanet/skorch.py diff --git a/pyaptamer/aptanet/__init__.py b/pyaptamer/aptanet/__init__.py index 272dd409..17038976 100644 --- a/pyaptamer/aptanet/__init__.py +++ b/pyaptamer/aptanet/__init__.py @@ -1,5 +1 @@ """The AptaNet algorithm""" - -from pyaptamer.aptanet._model import AptaNet - -__all__ = ["AptaNet"] diff --git a/pyaptamer/aptanet/_model.py b/pyaptamer/aptanet/_model.py index 98e3357e..ebb45733 100644 --- a/pyaptamer/aptanet/_model.py +++ b/pyaptamer/aptanet/_model.py @@ -1,3 +1,5 @@ +# TODO: Remove this file. + import numpy as np import torch import torch.nn as nn @@ -9,15 +11,34 @@ from pyaptamer.utils._aptanet_utils import generate_kmer_vecs -def aptanet_layer(input_dim: int, output_dim: int, dropout: float) -> nn.Sequential: +def aptanet_layer(input_dim, output_dim, dropout, lazy=False): """Create a single AptaNet layer with AlphaDropout and ReLU activation.""" + linear = nn.LazyLinear(output_dim) if lazy else nn.Linear(input_dim, output_dim) return nn.Sequential( - nn.Linear(input_dim, output_dim), + linear, nn.ReLU(), nn.AlphaDropout(dropout), ) +# NOTE: sklearn compatiblity skeleton code, to be removed later +# class AptaNet(TransformerMixin, BaseEstimator): +# def __init__(self): +# super().__init__() + +# def fit(self, X, y): +# X, y = validate_data(self, X, y) + +# def predict(self, X): +# check_is_fitted(self) + +# X = validate_data(self, X, reset=False) + +# if not hasattr(self, "clf_model_"): +# raise ValueError("Feature selector has not been fitted yet.") +# return self.clf_model_.transform(X) + + class AptaNet(nn.Module): """ AptaNet deep neural network for classification and feature generation. diff --git a/pyaptamer/aptanet/aptanet_nn.py b/pyaptamer/aptanet/aptanet_nn.py new file mode 100644 index 00000000..9b67ebfd --- /dev/null +++ b/pyaptamer/aptanet/aptanet_nn.py @@ -0,0 +1,51 @@ +import torch.nn as nn + + +def aptanet_layer(input_dim, output_dim, dropout, lazy=False): + """Create a single AptaNet layer with AlphaDropout and ReLU activation.""" + linear = nn.LazyLinear(output_dim) if lazy else nn.Linear(input_dim, output_dim) + return nn.Sequential( + linear, + nn.ReLU(), + nn.AlphaDropout(dropout), + ) + + +class AptaNetMLP(nn.Module): + """ + Vanilla MLP with optional lazy first layer. + + Parameters + ---------- + input_dim : int or None + If None and use_lazy=True, first layer is nn.LazyLinear. + hidden_dim : int + n_hidden : int + dropout : float + output_dim : int + use_lazy : bool + If True, ignore input_dim and build first layer lazily. + """ + + def __init__( + self, + input_dim=None, + hidden_dim=128, + n_hidden=7, + dropout=0.3, + output_dim=1, + use_lazy=True, + ): + super().__init__() + + first_lazy = use_lazy and (input_dim is None) + + layers = [aptanet_layer(input_dim, hidden_dim, dropout, lazy=first_lazy)] + for _ in range(n_hidden): + layers.append(aptanet_layer(hidden_dim, hidden_dim, dropout, lazy=False)) + + layers.append(nn.Linear(hidden_dim, output_dim)) + self.model = nn.Sequential(*layers) + + def forward(self, x): + return self.model(x) diff --git a/pyaptamer/aptanet/feature_selector.py b/pyaptamer/aptanet/feature_selector.py new file mode 100644 index 00000000..f8a34cb8 --- /dev/null +++ b/pyaptamer/aptanet/feature_selector.py @@ -0,0 +1,57 @@ +from sklearn.base import BaseEstimator, TransformerMixin +from sklearn.ensemble import RandomForestClassifier +from sklearn.feature_selection import SelectFromModel +from sklearn.utils.validation import check_is_fitted, validate_data + + +class FeatureSelector(TransformerMixin, BaseEstimator): + """ + Feature selector using Random Forest to select important features from the input + data. + + This class fits a Random Forest model to the training data and selects features + based on their importance scores. It is used to reduce the dimensionality of the + input data before training AptaNetMLP. + + Parameters + ---------- + n_estimators : int, optional + Number of trees in the forest (default is 300). + max_depth : int, optional + Maximum depth of the tree (default is 9). + random_state : int, optional + Random seed for reproducibility (default is 0). + Methods + ------- + fit(X, y) + Fit the feature selector to the training data. + transform(X) + Transform the input data by selecting important features. + """ + + def __init__(self, n_estimators=300, max_depth=9, random_state=0): + self.n_estimators = n_estimators + self.max_depth = max_depth + self.random_state = random_state + + def fit(self, X, y): + X, y = validate_data(self, X, y) + + self.clf_ = RandomForestClassifier( + n_estimators=self.n_estimators, + max_depth=self.max_depth, + random_state=self.random_state, + ) + self.clf_.fit(X, y) + self.clf_model_ = SelectFromModel(self.clf_, prefit=True) + return self + + def transform(self, X): + check_is_fitted(self) + + X = validate_data(self, X, reset=False) + + if not hasattr(self, "clf_model_"): + raise ValueError("Feature selector has not been fitted yet.") + + return self.clf_model_.transform(X) diff --git a/pyaptamer/aptanet/pipeline.py b/pyaptamer/aptanet/pipeline.py new file mode 100644 index 00000000..f45d7750 --- /dev/null +++ b/pyaptamer/aptanet/pipeline.py @@ -0,0 +1,39 @@ +import numpy as np +import torch +import torch.optim as optim +from sklearn.pipeline import Pipeline + +from pyaptamer.aptanet._model import FeatureSelector, SkorchAptaNet +from pyaptamer.pseaac import PSeAAC +from pyaptamer.utils._aptanet_utils import generate_kmer_vecs + + +# X is expected to be a list of tuples (aptamer_sequence, protein_sequence) +def pairs_to_features(X, k=4, pseaac_kwargs=None): + pseaac_kwargs = {} if pseaac_kwargs is None else pseaac_kwargs + pseaac = PSeAAC(**pseaac_kwargs) + + feats = [] + for aptamer_seq, protein_seq in X: + kmer = generate_kmer_vecs(aptamer_seq, k=k) + pseaac_vec = np.asarray(pseaac.transform(protein_seq)) + feats.append(np.concatenate([kmer, pseaac_vec])) + return np.vstack(feats) + + +net = SkorchAptaNet( + module__hidden_dim=128, + module__n_hidden=7, + module__dropout=0.3, + max_epochs=200, + lr=1.4e-4, + batch_size=310, + optimizer=optim.RMSprop, + device="cuda" if torch.cuda.is_available() else "cpu", + threshold=0.5, + verbose=1, +) + +pipe = Pipeline( + [("features", pairs_to_features), ("select", FeatureSelector()), ("clf", net)] +) diff --git a/pyaptamer/aptanet/skorch.py b/pyaptamer/aptanet/skorch.py new file mode 100644 index 00000000..d9e09835 --- /dev/null +++ b/pyaptamer/aptanet/skorch.py @@ -0,0 +1,14 @@ +import torch.nn as nn +from skorch import NeuralNetBinaryClassifier + +from pyaptamer.aptanet.aptanet_nn import AptaNetMLP + + +class SkorchAptaNet(NeuralNetBinaryClassifier): + def __init__(self, threshold=0.5, **kwargs): + self.threshold = threshold + super().__init__(module=AptaNetMLP, criterion=nn.BCEWithLogitsLoss, **kwargs) + + def predict(self, X): + proba = self.predict_proba(X)[:, 1] + return (proba > self.threshold).astype(int) diff --git a/pyaptamer/aptanet/tests/test_aptanet.py b/pyaptamer/aptanet/tests/test_aptanet.py index 241364da..d4d42eaa 100644 --- a/pyaptamer/aptanet/tests/test_aptanet.py +++ b/pyaptamer/aptanet/tests/test_aptanet.py @@ -1,7 +1,9 @@ import numpy as np import pytest +from sklearn.utils.estimator_checks import check_estimator from pyaptamer.aptanet import AptaNet +from pyaptamer.aptanet._model import FeatureSelector from pyaptamer.pseaac import PSeAAC @@ -46,3 +48,11 @@ def test_invalid_protein_sequence(): pseaac = PSeAAC() with pytest.raises(ValueError): pseaac.transform("ACDEXFGHIKL") # 'X' is not a valid amino acid + + +@pytest.mark.parametrize( + "estimator", [FeatureSelector(), AptaNet(n_layers=2, hidden_dim=32, dropout=0.1)] +) +def test_sklearn_compatible_estimator(estimator): + """Test the FeatureSelector class to ensure it behaves as a valid estimator.""" + check_estimator(estimator) From 6e6836ed0626172ba9a82965401484071e767d11 Mon Sep 17 00:00:00 2001 From: satvshr Date: Thu, 24 Jul 2025 02:49:59 +0530 Subject: [PATCH 046/145] Added pdb to string helper function --- pyproject.toml | 3 ++- utils/pdb_to_string.py | 19 +++++++++++++++++++ 2 files changed, 21 insertions(+), 1 deletion(-) create mode 100644 utils/pdb_to_string.py diff --git a/pyproject.toml b/pyproject.toml index 2ac1fd51..2ce57257 100644 --- a/pyproject.toml +++ b/pyproject.toml @@ -20,7 +20,8 @@ dependencies = [ dev = [ "ruff>=0.12.0", "pytest>=8.0.0", - "pre-commit" + "pre-commit", + "biopython>=1.83" ] [tool.ruff] diff --git a/utils/pdb_to_string.py b/utils/pdb_to_string.py new file mode 100644 index 00000000..43c6d6a2 --- /dev/null +++ b/utils/pdb_to_string.py @@ -0,0 +1,19 @@ +from Bio.PDB import PDBParser, PPBuilder + + +def extract_sequences_from_pdb(pdb_file_path): + """ + Extracts amino acid sequences from a PDB file using Biopython. + + Args: + pdb_file_path (str): Path to the PDB file. + + Returns: + List[str]: List of amino acid sequences (one per polypeptide). + """ + parser = PDBParser(QUIET=True) + structure = parser.get_structure("structure", pdb_file_path) + + ppb = PPBuilder() + sequences = [str(pp.get_sequence()) for pp in ppb.build_peptides(structure)] + return sequences From 73773af17a48ed4a5e697ac02e394c56d8c9c849 Mon Sep 17 00:00:00 2001 From: satvshr Date: Fri, 25 Jul 2025 02:22:15 +0530 Subject: [PATCH 047/145] Made requested changes --- pyaptamer/utils/pdb_to_string.py | 20 ++++++++++++++++++++ 1 file changed, 20 insertions(+) create mode 100644 pyaptamer/utils/pdb_to_string.py diff --git a/pyaptamer/utils/pdb_to_string.py b/pyaptamer/utils/pdb_to_string.py new file mode 100644 index 00000000..67f1af93 --- /dev/null +++ b/pyaptamer/utils/pdb_to_string.py @@ -0,0 +1,20 @@ +from Bio.PDB.Polypeptide import PPBuilder + + +def struct_to_aaseq(structure): + """ + Extract amino acid sequences from a Biopython Structure. + + Parameters + ---------- + structure : Bio.PDB.Structure.Structure + A Biopython Structure object (e.g. from PDBParser). + + Returns + ------- + sequences : list of str + List of amino acid sequences, one per polypeptide chain. + """ + ppb = PPBuilder() + sequences = [str(pp.get_sequence()) for pp in ppb.build_peptides(structure)] + return sequences From e2449e00fa1bbbff9288a1fc87e20f5e40fb41d0 Mon Sep 17 00:00:00 2001 From: satvshr Date: Fri, 25 Jul 2025 02:26:27 +0530 Subject: [PATCH 048/145] removed deleted files --- utils/pdb_to_string.py | 19 ------------------- 1 file changed, 19 deletions(-) delete mode 100644 utils/pdb_to_string.py diff --git a/utils/pdb_to_string.py b/utils/pdb_to_string.py deleted file mode 100644 index 43c6d6a2..00000000 --- a/utils/pdb_to_string.py +++ /dev/null @@ -1,19 +0,0 @@ -from Bio.PDB import PDBParser, PPBuilder - - -def extract_sequences_from_pdb(pdb_file_path): - """ - Extracts amino acid sequences from a PDB file using Biopython. - - Args: - pdb_file_path (str): Path to the PDB file. - - Returns: - List[str]: List of amino acid sequences (one per polypeptide). - """ - parser = PDBParser(QUIET=True) - structure = parser.get_structure("structure", pdb_file_path) - - ppb = PPBuilder() - sequences = [str(pp.get_sequence()) for pp in ppb.build_peptides(structure)] - return sequences From 212d54bba4ca8eeac734b03df9d7f1908ba9027b Mon Sep 17 00:00:00 2001 From: satvshr Date: Mon, 28 Jul 2025 17:55:46 +0530 Subject: [PATCH 049/145] Added architecture to support loaders along with a loader for PFOA --- .vscode/settings.json | 5 +++ pyaptamer/datasets/__init__.py | 1 + pyaptamer/datasets/data/__init__.py | 1 + pyaptamer/datasets/data/pfoa.pdb | 53 ++++++++++++++++++++++++ pyaptamer/datasets/loader/__init__.py | 5 +++ pyaptamer/datasets/loader/pfoa_loader.py | 25 +++++++++++ 6 files changed, 90 insertions(+) create mode 100644 .vscode/settings.json create mode 100644 pyaptamer/datasets/__init__.py create mode 100644 pyaptamer/datasets/data/__init__.py create mode 100644 pyaptamer/datasets/data/pfoa.pdb create mode 100644 pyaptamer/datasets/loader/__init__.py create mode 100644 pyaptamer/datasets/loader/pfoa_loader.py diff --git a/.vscode/settings.json b/.vscode/settings.json new file mode 100644 index 00000000..a8c20032 --- /dev/null +++ b/.vscode/settings.json @@ -0,0 +1,5 @@ +{ + "python-envs.defaultEnvManager": "ms-python.python:conda", + "python-envs.defaultPackageManager": "ms-python.python:conda", + "python-envs.pythonProjects": [] +} \ No newline at end of file diff --git a/pyaptamer/datasets/__init__.py b/pyaptamer/datasets/__init__.py new file mode 100644 index 00000000..44288b1c --- /dev/null +++ b/pyaptamer/datasets/__init__.py @@ -0,0 +1 @@ +"""Contains datasets along with their loaders.""" diff --git a/pyaptamer/datasets/data/__init__.py b/pyaptamer/datasets/data/__init__.py new file mode 100644 index 00000000..181a3a2f --- /dev/null +++ b/pyaptamer/datasets/data/__init__.py @@ -0,0 +1 @@ +"""Contains datasets for aptamers.""" diff --git a/pyaptamer/datasets/data/pfoa.pdb b/pyaptamer/datasets/data/pfoa.pdb new file mode 100644 index 00000000..3deccec7 --- /dev/null +++ b/pyaptamer/datasets/data/pfoa.pdb @@ -0,0 +1,53 @@ +HETATM 1 F1 UNL 1 -1.054 1.948 -0.201 1.00 0.00 F +HETATM 2 F2 UNL 1 0.543 1.258 -1.503 1.00 0.00 F +HETATM 3 F3 UNL 1 1.222 1.649 1.078 1.00 0.00 F +HETATM 4 F4 UNL 1 -0.333 0.293 1.758 1.00 0.00 F +HETATM 5 F5 UNL 1 -1.821 0.167 -2.165 1.00 0.00 F +HETATM 6 F6 UNL 1 -0.453 -1.320 -1.355 1.00 0.00 F +HETATM 7 F7 UNL 1 2.067 -0.762 1.916 1.00 0.00 F +HETATM 8 F8 UNL 1 0.806 -1.794 0.487 1.00 0.00 F +HETATM 9 F9 UNL 1 -2.983 -1.715 -0.682 1.00 0.00 F +HETATM 10 F10 UNL 1 -1.693 -1.305 1.021 1.00 0.00 F +HETATM 11 F11 UNL 1 2.105 -0.612 -1.601 1.00 0.00 F +HETATM 12 F12 UNL 1 3.342 -1.755 -0.237 1.00 0.00 F +HETATM 13 F13 UNL 1 -3.968 0.842 -0.596 1.00 0.00 F +HETATM 14 F14 UNL 1 -2.683 1.301 1.109 1.00 0.00 F +HETATM 15 F15 UNL 1 -4.173 -0.274 1.267 1.00 0.00 F +HETATM 16 O1 UNL 1 4.570 0.329 0.674 1.00 0.00 O +HETATM 17 O2 UNL 1 3.367 1.677 -0.704 1.00 0.00 O +HETATM 18 C1 UNL 1 -0.291 0.860 -0.511 1.00 0.00 C +HETATM 19 C2 UNL 1 0.531 0.526 0.727 1.00 0.00 C +HETATM 20 C3 UNL 1 -1.214 -0.239 -1.021 1.00 0.00 C +HETATM 21 C4 UNL 1 1.506 -0.643 0.678 1.00 0.00 C +HETATM 22 C5 UNL 1 -2.285 -0.725 -0.056 1.00 0.00 C +HETATM 23 C6 UNL 1 2.630 -0.597 -0.348 1.00 0.00 C +HETATM 24 C7 UNL 1 -3.279 0.300 0.430 1.00 0.00 C +HETATM 25 C8 UNL 1 3.539 0.591 -0.167 1.00 0.00 C +HETATM 26 H1 UNL 1 5.153 1.108 0.793 1.00 0.00 H +CONECT 1 18 +CONECT 2 18 +CONECT 3 19 +CONECT 4 19 +CONECT 5 20 +CONECT 6 20 +CONECT 7 21 +CONECT 8 21 +CONECT 9 22 +CONECT 10 22 +CONECT 11 23 +CONECT 12 23 +CONECT 13 24 +CONECT 14 24 +CONECT 15 24 +CONECT 16 25 26 +CONECT 17 25 +CONECT 18 1 2 19 20 +CONECT 19 3 4 18 21 +CONECT 20 5 6 18 22 +CONECT 21 7 8 19 23 +CONECT 22 9 10 20 24 +CONECT 23 11 12 21 25 +CONECT 24 13 14 15 22 +CONECT 25 16 17 23 +CONECT 26 16 +END diff --git a/pyaptamer/datasets/loader/__init__.py b/pyaptamer/datasets/loader/__init__.py new file mode 100644 index 00000000..9e23ab37 --- /dev/null +++ b/pyaptamer/datasets/loader/__init__.py @@ -0,0 +1,5 @@ +"""Loaders for different data structures.""" + +from pyaptamer.datasets.loader.pfoa_loader import load_pfoa_structure + +__all__ = ["load_pfoa_structure"] diff --git a/pyaptamer/datasets/loader/pfoa_loader.py b/pyaptamer/datasets/loader/pfoa_loader.py new file mode 100644 index 00000000..bb56573b --- /dev/null +++ b/pyaptamer/datasets/loader/pfoa_loader.py @@ -0,0 +1,25 @@ +import os + +from Bio.PDB import PDBParser + + +def load_pfoa_structure(pdb_path=None): + """ + Load the PFOA molecule from a PDB file using Biopython. + + Parameters + ---------- + pdb_path : str, optional + Path to the PDB file. If not provided, the function uses the default path + located in the '../data/pfoa.pdb' relative to the current file. + + Returns + ------- + structure : Bio.PDB.Structure.Structure + A Biopython Structure object representing the PFOA molecule. + """ + pdb_path = os.path.join(os.path.dirname(__file__), "..", "data", "pfoa.pdb") + + parser = PDBParser(QUIET=True) + structure = parser.get_structure("PFOA", pdb_path) + return structure From 3b09533c1394ed5735625a7d1109cb39bf4ec206 Mon Sep 17 00:00:00 2001 From: satvshr Date: Mon, 28 Jul 2025 18:11:34 +0530 Subject: [PATCH 050/145] Added tests --- .../{pdb_to_string.py => struct_to_aaseq.py} | 0 pyaptamer/utils/tests/struct_to_aaseq_test.py | 17 +++++++++++++++++ 2 files changed, 17 insertions(+) rename pyaptamer/utils/{pdb_to_string.py => struct_to_aaseq.py} (100%) create mode 100644 pyaptamer/utils/tests/struct_to_aaseq_test.py diff --git a/pyaptamer/utils/pdb_to_string.py b/pyaptamer/utils/struct_to_aaseq.py similarity index 100% rename from pyaptamer/utils/pdb_to_string.py rename to pyaptamer/utils/struct_to_aaseq.py diff --git a/pyaptamer/utils/tests/struct_to_aaseq_test.py b/pyaptamer/utils/tests/struct_to_aaseq_test.py new file mode 100644 index 00000000..30457d4f --- /dev/null +++ b/pyaptamer/utils/tests/struct_to_aaseq_test.py @@ -0,0 +1,17 @@ +import pytest + +from pyaptamer.datasets.loader import load_pfoa_structure +from pyaptamer.utils.struct_to_aaseq import struct_to_aaseq + + +def test_struct_to_aaseq_runs_and_returns_expected_type(): + structure = load_pfoa_structure() + + try: + sequences = struct_to_aaseq(structure) + except Exception as e: + pytest.fail(f"struct_to_aaseq raised an exception: {e}") + + assert isinstance(sequences, list), "Return value should be a list" + for seq in sequences: + assert isinstance(seq, str), "Each sequence should be a string" From 9d9738f115d8ac520e333a4df8fe637c00121d12 Mon Sep 17 00:00:00 2001 From: satvshr Date: Mon, 28 Jul 2025 18:20:16 +0530 Subject: [PATCH 051/145] Added tests --- pyaptamer/datasets/tests/test_pfoa.py | 24 ++++++++++++++++++++++++ 1 file changed, 24 insertions(+) create mode 100644 pyaptamer/datasets/tests/test_pfoa.py diff --git a/pyaptamer/datasets/tests/test_pfoa.py b/pyaptamer/datasets/tests/test_pfoa.py new file mode 100644 index 00000000..209937ed --- /dev/null +++ b/pyaptamer/datasets/tests/test_pfoa.py @@ -0,0 +1,24 @@ +import pytest +from Bio.PDB.Structure import Structure + +from pyaptamer.datasets.loader import load_pfoa_structure + + +def test_load_pfoa_structure_runs_and_returns_structure(): + """ + Test that the load_pfoa_structure function runs without error and returns a valid + Structure object. + + Asserts + ------- + The datasets loads and the return value must be an instance of Biopython's + Structure class. + """ + try: + structure = load_pfoa_structure() + except Exception as e: + pytest.fail(f"load_pfoa_structure raised an exception: {e}") + + assert isinstance(structure, Structure), ( + "Returned object is not a Biopython Structure" + ) From 210f09c330f48c705f33d45b1c110a6d15707bc4 Mon Sep 17 00:00:00 2001 From: satvshr Date: Mon, 28 Jul 2025 18:21:17 +0530 Subject: [PATCH 052/145] Renamed test file --- .../tests/{struct_to_aaseq_test.py => test_struct_to_aaseq.py} | 0 1 file changed, 0 insertions(+), 0 deletions(-) rename pyaptamer/utils/tests/{struct_to_aaseq_test.py => test_struct_to_aaseq.py} (100%) diff --git a/pyaptamer/utils/tests/struct_to_aaseq_test.py b/pyaptamer/utils/tests/test_struct_to_aaseq.py similarity index 100% rename from pyaptamer/utils/tests/struct_to_aaseq_test.py rename to pyaptamer/utils/tests/test_struct_to_aaseq.py From 6fb1db5b95f91f21fc750a8d154b2899752e640f Mon Sep 17 00:00:00 2001 From: satvshr Date: Tue, 29 Jul 2025 02:10:29 +0530 Subject: [PATCH 053/145] Made requested changes --- pyaptamer/datasets/tests/test_pfoa.py | 6 +----- 1 file changed, 1 insertion(+), 5 deletions(-) diff --git a/pyaptamer/datasets/tests/test_pfoa.py b/pyaptamer/datasets/tests/test_pfoa.py index 209937ed..12f2ae16 100644 --- a/pyaptamer/datasets/tests/test_pfoa.py +++ b/pyaptamer/datasets/tests/test_pfoa.py @@ -1,4 +1,3 @@ -import pytest from Bio.PDB.Structure import Structure from pyaptamer.datasets.loader import load_pfoa_structure @@ -14,10 +13,7 @@ def test_load_pfoa_structure_runs_and_returns_structure(): The datasets loads and the return value must be an instance of Biopython's Structure class. """ - try: - structure = load_pfoa_structure() - except Exception as e: - pytest.fail(f"load_pfoa_structure raised an exception: {e}") + structure = load_pfoa_structure() assert isinstance(structure, Structure), ( "Returned object is not a Biopython Structure" From 2dbf5d591590caada7cde3a84f964a8bd3d9de90 Mon Sep 17 00:00:00 2001 From: satvshr Date: Tue, 29 Jul 2025 15:39:30 +0530 Subject: [PATCH 054/145] Stop tracking .vscode folder --- .vscode/settings.json | 14 -------------- 1 file changed, 14 deletions(-) delete mode 100644 .vscode/settings.json diff --git a/.vscode/settings.json b/.vscode/settings.json deleted file mode 100644 index 5e318df4..00000000 --- a/.vscode/settings.json +++ /dev/null @@ -1,14 +0,0 @@ -{ - "python.testing.pytestArgs": [ - "pyaptamer" - ], - "python.testing.unittestEnabled": true, - "python.testing.pytestEnabled": false, - "python.testing.unittestArgs": [ - "-v", - "-s", - "./pyaptamer", - "-p", - "test_*.py" - ] -} \ No newline at end of file From 8767f115c346f3d43d0b1eca7c36a6f3f5f3791c Mon Sep 17 00:00:00 2001 From: satvshr Date: Tue, 29 Jul 2025 15:41:45 +0530 Subject: [PATCH 055/145] Added docstrings --- pyaptamer/aptanet/__init__.py | 5 + pyaptamer/aptanet/_model.py | 273 ------------------------ pyaptamer/aptanet/aptanet_nn.py | 84 +++++++- pyaptamer/aptanet/feature_selector.py | 34 +-- pyaptamer/aptanet/pipeline.py | 31 ++- pyaptamer/aptanet/skorch.py | 30 +++ pyaptamer/aptanet/tests/test_aptanet.py | 41 ++-- pyproject.toml | 3 +- 8 files changed, 187 insertions(+), 314 deletions(-) delete mode 100644 pyaptamer/aptanet/_model.py diff --git a/pyaptamer/aptanet/__init__.py b/pyaptamer/aptanet/__init__.py index 17038976..da411b74 100644 --- a/pyaptamer/aptanet/__init__.py +++ b/pyaptamer/aptanet/__init__.py @@ -1 +1,6 @@ """The AptaNet algorithm""" + +from pyaptamer.aptanet.feature_selector import FeatureSelector +from pyaptamer.aptanet.skorch import SkorchAptaNet + +__all__ = ["FeatureSelector", "SkorchAptaNet"] diff --git a/pyaptamer/aptanet/_model.py b/pyaptamer/aptanet/_model.py deleted file mode 100644 index ebb45733..00000000 --- a/pyaptamer/aptanet/_model.py +++ /dev/null @@ -1,273 +0,0 @@ -# TODO: Remove this file. - -import numpy as np -import torch -import torch.nn as nn -import torch.optim as optim -from sklearn.ensemble import RandomForestClassifier -from sklearn.feature_selection import SelectFromModel - -from pyaptamer.pseaac import PSeAAC -from pyaptamer.utils._aptanet_utils import generate_kmer_vecs - - -def aptanet_layer(input_dim, output_dim, dropout, lazy=False): - """Create a single AptaNet layer with AlphaDropout and ReLU activation.""" - linear = nn.LazyLinear(output_dim) if lazy else nn.Linear(input_dim, output_dim) - return nn.Sequential( - linear, - nn.ReLU(), - nn.AlphaDropout(dropout), - ) - - -# NOTE: sklearn compatiblity skeleton code, to be removed later -# class AptaNet(TransformerMixin, BaseEstimator): -# def __init__(self): -# super().__init__() - -# def fit(self, X, y): -# X, y = validate_data(self, X, y) - -# def predict(self, X): -# check_is_fitted(self) - -# X = validate_data(self, X, reset=False) - -# if not hasattr(self, "clf_model_"): -# raise ValueError("Feature selector has not been fitted yet.") -# return self.clf_model_.transform(X) - - -class AptaNet(nn.Module): - """ - AptaNet deep neural network for classification and feature generation. - - This class generates a combined feature vector using k-mer frequencies from the - aptamer DNA sequence and PseAAC features from the protein sequence, and provides - a deep neural network to classify binding interactions between aptamers and - proteins, with a binary output (0 or 1). - - References - ---------- - Emami, N., Ferdousi, R. AptaNet as a deep learning approach for aptamer–protein - interaction prediction. Sci Rep 11, 6074 (2021). - - Parameters - ---------- - n_layers : int - Number of hidden layers. - hidden_dim : int - Hidden layer dimension. - output_dim : int - Output feature dimension. - dropout : float - Dropout rate for AlphaDropout. - - Example - -------- - >>> aptanet = AptaNet(n_layers=5, hidden_dim=128, dropout=0.3) - >>> aptanet.fit(X_train, y_train, epochs=100, batch_size=32) - >>> predictions = aptanet.predict(X_test) - >>> feature_vector = aptanet.preprocessing(aptamer_sequence, protein_sequence) - >>> print(feature_vector[:10]) - np.array([0.05, 0.05, 0.05, 0.05, 0.05, 0.05, 0.05, 0.05, 0.05, 0.05]) - - Methods - ---------- - forward(X) - Forward pass through the network. - fit(X, y, epochs, batch_size) - Fit the AptaNet model to the training data. - predict(X) - Predict binary class labels for input samples. - preprocessing(aptamer_sequence, protein_sequence) - Generate the final feature vector by concatenating k-mer and PseAAC features. - """ - - def __init__( - self, - n_layers=7, - hidden_dim=128, - dropout=0.3, - output_dim=1, - ): - super().__init__() - assert n_layers > 0, "Number of hidden layers must be greater than 0." - - self.input_dim = None # Will be set after feature selection - self.output_dim = output_dim # Binary classification - self.hidden_dim = hidden_dim - self.n_layers = n_layers - self.dropout = dropout - self.criterion = nn.BCEWithLogitsLoss() - # Optimizer will be initialized during training (lack of self.parameters()) - self.optimizer = None - self.clf = RandomForestClassifier( - n_estimators=300, max_depth=9, random_state=0 - ) # Random forest feature selector - self.clf_model = None # Feature selector model after fitting - self.model = None # Will be initialized after feature selection - - def _init_model(self, input_dim): - """Initialize AptaNet's deep neural network after feature selection.""" - model = [aptanet_layer(input_dim, self.hidden_dim, self.dropout)] - for _ in range(self.n_layers): - model.append(aptanet_layer(self.hidden_dim, self.hidden_dim, self.dropout)) - model.append(nn.Linear(self.hidden_dim, self.output_dim)) - return nn.Sequential(*model) - - def forward(self, X): - """ - Forward pass through the network. - - Parameters - ---------- - X : torch.Tensor - Input tensor of shape (batch_size, n_features). - - Returns - ------- - torch.Tensor - Output tensor with predicted probabilities. - """ - return self.model(X) - - def _train_clf_model(self, X, y): - """ - Train the random forest feature selector. - - Parameters - ---------- - X : array-like of shape (n_samples, n_features) - Training input samples. - y : array-like of shape (n_samples,) - Target values. - - Returns - ------- - SelectFromModel - Trained feature selector. - """ - self.clf.fit(X, y) - self.clf_model = SelectFromModel(self.clf, prefit=True) - return self.clf_model - - def _transform_x(self, X): - """ - Transform input features using the trained feature selector. - - Parameters - ---------- - X : array-like of shape (n_samples, n_features) - Input samples. - - Returns - ------- - array-like - Transformed input samples with selected features. - - Raises - ------ - ValueError - If the feature selector has not been trained. - """ - if self.clf_model is None: - raise ValueError("Classifier model has not been trained yet.") - return self.clf_model.transform(X) - - def fit(self, X, y, epochs=200, batch_size=310): - """ - Fit the AptaNet model to the training data. - - Parameters - ---------- - X : array-like of shape (n_samples, n_features) - Training input samples. - y : array-like of shape (n_samples,) - Target values. - epochs : int, optional - Number of training epochs (default is 200). - batch_size : int, optional - Batch size for training (default is 310). - """ - # Feature selection - self.clf_model = self._train_clf_model(X, y) - X_transformed = self._transform_x(X) - self.input_dim = X_transformed.shape[1] - # Initialize the model with the selected input dimension - self.model = self._init_model(self.input_dim) - X_tensor = torch.tensor(X_transformed, dtype=torch.float32) - y_tensor = torch.tensor(y, dtype=torch.float32).unsqueeze(1) - - self.optimizer = optim.RMSprop( - self.parameters(), lr=0.00014, alpha=0.9, eps=1e-07 - ) - - dataset = torch.utils.data.TensorDataset(X_tensor, y_tensor) - dataloader = torch.utils.data.DataLoader( - dataset, batch_size=batch_size, shuffle=True - ) - - self.train() - for _epoch in range(epochs): - for batch_x, batch_y in dataloader: - self.optimizer.zero_grad() - output = self(batch_x) - loss = self.criterion(output, batch_y) - loss.backward() - self.optimizer.step() - - def predict(self, X): - """ - Predict binary class labels for input samples. - - Parameters - ---------- - X : array-like of shape (n_samples, n_features) - Input samples. - - Returns - ------- - numpy.ndarray - Predicted class labels (0 or 1). - """ - self.eval() - X_transformed = self._transform_x(X) - X_tensor = torch.tensor(X_transformed, dtype=torch.float32) - with torch.no_grad(): - logits = self(X_tensor) - probs = torch.sigmoid(logits) - predictions = (probs > 0.5).int().squeeze().numpy() - return predictions - - def preprocessing(self, aptamer_sequence, protein_sequence): - """ - Generate the final feature vector by concatenating k-mer and PseAAC features. - - Parameters - ---------- - aptamer_sequence : str - The DNA sequence of the aptamer. - protein_sequence : str - The protein sequence to be analyzed. - - Returns - ------- - np.ndarray - 1D numpy array of combined feature vector for the aptamer-protein pair. - """ - self.aptamer_sequence = aptamer_sequence - self.protein_sequence = protein_sequence - - self.pseaac = PSeAAC() - self.pseaac_sequence = self.pseaac.transform(protein_sequence) - - final_vector = np.concatenate( - [ - generate_kmer_vecs(self.aptamer_sequence, k=4), - np.array(self.pseaac_sequence), - ] - ) - - return final_vector diff --git a/pyaptamer/aptanet/aptanet_nn.py b/pyaptamer/aptanet/aptanet_nn.py index 9b67ebfd..56f4ac58 100644 --- a/pyaptamer/aptanet/aptanet_nn.py +++ b/pyaptamer/aptanet/aptanet_nn.py @@ -1,8 +1,37 @@ +__author__ = "satvshr" +__all__ = ["AptaNetMLP"] + import torch.nn as nn def aptanet_layer(input_dim, output_dim, dropout, lazy=False): - """Create a single AptaNet layer with AlphaDropout and ReLU activation.""" + """ + Create a single AptaNet layer composed of a linear transformation, + ReLU activation, and AlphaDropout. + + Parameters + ---------- + input_dim : int + Size of each input sample. Ignored if `lazy=True`. + + output_dim : int + Size of each output sample (i.e., number of neurons in the layer). + + dropout : float + Dropout probability for AlphaDropout. Must be between 0 and 1. + + lazy : bool, optional + If True, use `nn.LazyLinear` instead of `nn.Linear`, allowing the input + size to be inferred at runtime. Default is False. + + Returns + ------- + nn.Sequential + A sequential container with: + - Linear or LazyLinear layer + - ReLU activation + - AlphaDropout layer + """ linear = nn.LazyLinear(output_dim) if lazy else nn.Linear(input_dim, output_dim) return nn.Sequential( linear, @@ -13,18 +42,39 @@ def aptanet_layer(input_dim, output_dim, dropout, lazy=False): class AptaNetMLP(nn.Module): """ - Vanilla MLP with optional lazy first layer. + A fully-connected (vanilla) multi-layer perceptron (MLP). + + This model supports lazy initialization for the first linear layer if the input + dimension is unknown at instantiation time. Hidden layers use a customizable number + of layers, hidden units, and dropout. Parameters ---------- - input_dim : int or None - If None and use_lazy=True, first layer is nn.LazyLinear. - hidden_dim : int - n_hidden : int - dropout : float - output_dim : int - use_lazy : bool - If True, ignore input_dim and build first layer lazily. + input_dim : int or None, optional + Dimensionality of the input features. If None and `use_lazy=True`, the first + layer is lazily initialized. Required if `use_lazy=False`. Default is None. + + hidden_dim : int, optional + Number of units in each hidden layer. Default is 128. + + n_hidden : int, optional + Number of hidden layers. Default is 7. + + dropout : float, optional + Dropout rate applied after each hidden layer. Default is 0.3. + + output_dim : int, optional + Dimensionality of the output layer. Typically 1 for binary classification or + regression. Default is 1. + + use_lazy : bool, optional + If True, the first layer is initialized lazily using `nn.LazyLinear`. + Default is True. + + Attributes + ---------- + model : nn.Sequential + The sequential container of layers making up the MLP. """ def __init__( @@ -48,4 +98,18 @@ def __init__( self.model = nn.Sequential(*layers) def forward(self, x): + """ + Perform a forward pass through the network. + + Parameters + ---------- + x : torch.Tensor + Input tensor of shape (batch_size, input_dim). If using lazy layers, + the input shape will determine the first layer's dimensions at runtime. + + Returns + ------- + torch.Tensor + Output tensor of shape (batch_size, output_dim), containing logits. + """ return self.model(x) diff --git a/pyaptamer/aptanet/feature_selector.py b/pyaptamer/aptanet/feature_selector.py index f8a34cb8..44af4b26 100644 --- a/pyaptamer/aptanet/feature_selector.py +++ b/pyaptamer/aptanet/feature_selector.py @@ -1,3 +1,6 @@ +__author__ = "satvshr" +__all__ = ["FeatureSelector"] + from sklearn.base import BaseEstimator, TransformerMixin from sklearn.ensemble import RandomForestClassifier from sklearn.feature_selection import SelectFromModel @@ -6,27 +9,30 @@ class FeatureSelector(TransformerMixin, BaseEstimator): """ - Feature selector using Random Forest to select important features from the input - data. + Feature selector using a Random Forest classifier to identify and retain + important features based on feature importances. - This class fits a Random Forest model to the training data and selects features - based on their importance scores. It is used to reduce the dimensionality of the - input data before training AptaNetMLP. + This transformer can be used in scikit-learn pipelines to perform automatic + feature selection as a preprocessing step before model training. Parameters ---------- n_estimators : int, optional - Number of trees in the forest (default is 300). + Number of trees in the random forest. Default is 300. + max_depth : int, optional - Maximum depth of the tree (default is 9). + Maximum depth of the trees. Default is 9. + random_state : int, optional - Random seed for reproducibility (default is 0). - Methods - ------- - fit(X, y) - Fit the feature selector to the training data. - transform(X) - Transform the input data by selecting important features. + Seed used by the random number generator. Default is 0. + + Attributes + ---------- + clf_ : RandomForestClassifier + Fitted random forest classifier used to compute feature importances. + + clf_model_ : SelectFromModel + Model used to select features based on importances from the fitted classifier. """ def __init__(self, n_estimators=300, max_depth=9, random_state=0): diff --git a/pyaptamer/aptanet/pipeline.py b/pyaptamer/aptanet/pipeline.py index f45d7750..5af54b5d 100644 --- a/pyaptamer/aptanet/pipeline.py +++ b/pyaptamer/aptanet/pipeline.py @@ -3,13 +3,40 @@ import torch.optim as optim from sklearn.pipeline import Pipeline -from pyaptamer.aptanet._model import FeatureSelector, SkorchAptaNet +from pyaptamer.aptanet import FeatureSelector, SkorchAptaNet from pyaptamer.pseaac import PSeAAC from pyaptamer.utils._aptanet_utils import generate_kmer_vecs -# X is expected to be a list of tuples (aptamer_sequence, protein_sequence) def pairs_to_features(X, k=4, pseaac_kwargs=None): + """ + Convert a list of (aptamer_sequence, protein_sequence) pairs into feature vectors. + + This function generates feature vectors for each (aptamer, protein) pair using: + - k-mer representation of the aptamer sequence + - Pseudo amino acid composition (PSeAAC) representation of the protein sequence + + Parameters + ---------- + X : list of tuple of str + A list where each element is a tuple `(aptamer_sequence, protein_sequence)`. + `aptamer_sequence` should be a string of nucleotides, and `protein_sequence` + should be a string of amino acids. + + k : int, optional + The k-mer size used to generate the k-mer vector from the aptamer sequence. + Default is 4. + + pseaac_kwargs : dict, optional + Optional keyword arguments to pass to the `PSeAAC` transformer. + If not provided, default parameters are used. + + Returns + ------- + np.ndarray + A 2D NumPy array where each row corresponds to the concatenated feature vector + for a given (aptamer, protein) pair. + """ pseaac_kwargs = {} if pseaac_kwargs is None else pseaac_kwargs pseaac = PSeAAC(**pseaac_kwargs) diff --git a/pyaptamer/aptanet/skorch.py b/pyaptamer/aptanet/skorch.py index d9e09835..c919e9e3 100644 --- a/pyaptamer/aptanet/skorch.py +++ b/pyaptamer/aptanet/skorch.py @@ -1,3 +1,6 @@ +__author__ = "satvshr" +__all__ = ["SkorchAptaNet"] + import torch.nn as nn from skorch import NeuralNetBinaryClassifier @@ -5,6 +8,33 @@ class SkorchAptaNet(NeuralNetBinaryClassifier): + """ + A Skorch-based binary classifier using AptaNetMLP with a configurable threshold. + + This class wraps a PyTorch-based multilayer perceptron (MLP) model `AptaNetMLP` + using the Skorch API. It is designed for binary classification tasks, using the + binary cross-entropy loss with logits (`BCEWithLogitsLoss`) and a configurable + threshold for converting predicted probabilities to class labels. + + Parameters + ---------- + threshold : float, optional (default=0.5) + The decision threshold for converting probabilities into binary predictions. + Probabilities above this threshold are mapped to class 1, otherwise to class 0. + + **kwargs : dict + Additional keyword arguments passed to `NeuralNetBinaryClassifier`. + To configure the underlying `AptaNetMLP` module, use the `module__` + syntax. For example, `module__hidden_size=128` will pass `hidden_size=128` + to `AptaNetMLP`. + + Methods + ------- + predict(X) + Predicts class labels for the input data `X` using the fitted model. + Returns binary predictions based on the specified threshold. + """ + def __init__(self, threshold=0.5, **kwargs): self.threshold = threshold super().__init__(module=AptaNetMLP, criterion=nn.BCEWithLogitsLoss, **kwargs) diff --git a/pyaptamer/aptanet/tests/test_aptanet.py b/pyaptamer/aptanet/tests/test_aptanet.py index d4d42eaa..824b3424 100644 --- a/pyaptamer/aptanet/tests/test_aptanet.py +++ b/pyaptamer/aptanet/tests/test_aptanet.py @@ -1,9 +1,10 @@ import numpy as np import pytest +import torch from sklearn.utils.estimator_checks import check_estimator -from pyaptamer.aptanet import AptaNet -from pyaptamer.aptanet._model import FeatureSelector +from pyaptamer.aptanet import FeatureSelector, SkorchAptaNet +from pyaptamer.aptanet.pipeline import pairs_to_features from pyaptamer.pseaac import PSeAAC @@ -11,28 +12,40 @@ "aptamer_seq, protein_seq", [ ( - "ACDEFGHIKLMNPQRSTVWYACDEFGHIKLMNPQRSTVWY", "AGCTTAGCGTACAGCTTAAAAGGGTTTCCCCTGCCCGCGTAC", + "ACDEFGHIKLMNPQRSTVWYACDEFGHIKLMNPQRSTVWY", ) ], ) def test_model_fit_and_predict(aptamer_seq, protein_seq): """ - Test AptaNet fitting and predicting on synthetic data. + Test SkorchAptaNet fitting and predicting on synthetic data. Asserts ------- Model predictions are valid class labels and shape matches input. """ - model = AptaNet(n_layers=3, hidden_dim=64, dropout=0.2) - - # Generate dummy feature matrix - X = np.array([model.preprocessing(aptamer_seq, protein_seq) for _ in range(40)]) + # Generate dummy input + X_raw = [(aptamer_seq, protein_seq) for _ in range(40)] y = np.array([0] * 20 + [1] * 20) - model.fit(X, y, epochs=5, batch_size=10) + # Convert sequence pairs to features + X = pairs_to_features(X_raw) + + # Initialize model + net = SkorchAptaNet( + module__hidden_dim=64, + module__n_hidden=3, + module__dropout=0.2, + max_epochs=5, + batch_size=10, + device="cuda" if torch.cuda.is_available() else "cpu", + verbose=0, + ) + + net.fit(X, y) + preds = net.predict(X) - preds = model.predict(X) assert preds.shape == (40,) assert set(preds).issubset({0, 1}) @@ -50,9 +63,9 @@ def test_invalid_protein_sequence(): pseaac.transform("ACDEXFGHIKL") # 'X' is not a valid amino acid -@pytest.mark.parametrize( - "estimator", [FeatureSelector(), AptaNet(n_layers=2, hidden_dim=32, dropout=0.1)] -) +@pytest.mark.parametrize("estimator", [FeatureSelector()]) def test_sklearn_compatible_estimator(estimator): - """Test the FeatureSelector class to ensure it behaves as a valid estimator.""" + """ + Test that FeatureSelector is compatible with scikit-learn estimator checks. + """ check_estimator(estimator) diff --git a/pyproject.toml b/pyproject.toml index add60213..5ef92ba9 100644 --- a/pyproject.toml +++ b/pyproject.toml @@ -23,7 +23,8 @@ dev = [ "pytest>=8.0.0", "torch>=2.0.0", "scikit-learn>=1.3.0", - "pre-commit" + "pre-commit", + "python>=12.0.0,<13.0.0" ] [tool.ruff] From 32d7673bab5abe1bbd74bce12cf00379ec3616a9 Mon Sep 17 00:00:00 2001 From: satvshr Date: Tue, 29 Jul 2025 15:46:57 +0530 Subject: [PATCH 056/145] Fixed bugs to ensure pytorch compatibility by type-casting to float32 --- pyaptamer/aptanet/pipeline.py | 4 +++- pyaptamer/aptanet/tests/test_aptanet.py | 16 +--------------- 2 files changed, 4 insertions(+), 16 deletions(-) diff --git a/pyaptamer/aptanet/pipeline.py b/pyaptamer/aptanet/pipeline.py index 5af54b5d..c2bb5f2f 100644 --- a/pyaptamer/aptanet/pipeline.py +++ b/pyaptamer/aptanet/pipeline.py @@ -45,7 +45,9 @@ def pairs_to_features(X, k=4, pseaac_kwargs=None): kmer = generate_kmer_vecs(aptamer_seq, k=k) pseaac_vec = np.asarray(pseaac.transform(protein_seq)) feats.append(np.concatenate([kmer, pseaac_vec])) - return np.vstack(feats) + + # Ensure float32 for PyTorch compatibility + return np.vstack(feats).astype(np.float32) net = SkorchAptaNet( diff --git a/pyaptamer/aptanet/tests/test_aptanet.py b/pyaptamer/aptanet/tests/test_aptanet.py index 824b3424..63571345 100644 --- a/pyaptamer/aptanet/tests/test_aptanet.py +++ b/pyaptamer/aptanet/tests/test_aptanet.py @@ -5,7 +5,6 @@ from pyaptamer.aptanet import FeatureSelector, SkorchAptaNet from pyaptamer.aptanet.pipeline import pairs_to_features -from pyaptamer.pseaac import PSeAAC @pytest.mark.parametrize( @@ -27,7 +26,7 @@ def test_model_fit_and_predict(aptamer_seq, protein_seq): """ # Generate dummy input X_raw = [(aptamer_seq, protein_seq) for _ in range(40)] - y = np.array([0] * 20 + [1] * 20) + y = np.array([0] * 20 + [1] * 20, dtype=np.float32) # Convert sequence pairs to features X = pairs_to_features(X_raw) @@ -50,19 +49,6 @@ def test_model_fit_and_predict(aptamer_seq, protein_seq): assert set(preds).issubset({0, 1}) -def test_invalid_protein_sequence(): - """ - Test PSeAAC raises ValueError on invalid amino acids. - - Asserts - ------- - ValueError is raised for an invalid protein sequence. - """ - pseaac = PSeAAC() - with pytest.raises(ValueError): - pseaac.transform("ACDEXFGHIKL") # 'X' is not a valid amino acid - - @pytest.mark.parametrize("estimator", [FeatureSelector()]) def test_sklearn_compatible_estimator(estimator): """ From f94cd6ad84972083536d1fc4a281b1d149a2fef6 Mon Sep 17 00:00:00 2001 From: satvshr Date: Tue, 29 Jul 2025 17:28:35 +0530 Subject: [PATCH 057/145] Added an improved test to test the pipeline instead --- pyaptamer/aptanet/pipeline.py | 11 ++++++++- pyaptamer/aptanet/tests/test_aptanet.py | 31 +++++++------------------ 2 files changed, 18 insertions(+), 24 deletions(-) diff --git a/pyaptamer/aptanet/pipeline.py b/pyaptamer/aptanet/pipeline.py index c2bb5f2f..9067f932 100644 --- a/pyaptamer/aptanet/pipeline.py +++ b/pyaptamer/aptanet/pipeline.py @@ -2,6 +2,7 @@ import torch import torch.optim as optim from sklearn.pipeline import Pipeline +from sklearn.preprocessing import FunctionTransformer from pyaptamer.aptanet import FeatureSelector, SkorchAptaNet from pyaptamer.pseaac import PSeAAC @@ -63,6 +64,14 @@ def pairs_to_features(X, k=4, pseaac_kwargs=None): verbose=1, ) +feature_transformer = FunctionTransformer( + func=pairs_to_features, + validate=False, + # Optional arguments for pairs_to_features + # example: kw_args={'k': 4, 'pseaac_kwargs': {'lambda_value': 30}} + kw_args={}, +) + pipe = Pipeline( - [("features", pairs_to_features), ("select", FeatureSelector()), ("clf", net)] + [("features", feature_transformer), ("select", FeatureSelector()), ("clf", net)] ) diff --git a/pyaptamer/aptanet/tests/test_aptanet.py b/pyaptamer/aptanet/tests/test_aptanet.py index 63571345..1aa1ba20 100644 --- a/pyaptamer/aptanet/tests/test_aptanet.py +++ b/pyaptamer/aptanet/tests/test_aptanet.py @@ -1,10 +1,9 @@ import numpy as np import pytest -import torch from sklearn.utils.estimator_checks import check_estimator -from pyaptamer.aptanet import FeatureSelector, SkorchAptaNet -from pyaptamer.aptanet.pipeline import pairs_to_features +from pyaptamer.aptanet import FeatureSelector +from pyaptamer.aptanet.pipeline import pipe @pytest.mark.parametrize( @@ -16,34 +15,20 @@ ) ], ) -def test_model_fit_and_predict(aptamer_seq, protein_seq): +def test_pipeline_fit_and_predict(aptamer_seq, protein_seq): """ - Test SkorchAptaNet fitting and predicting on synthetic data. + Test end‐to‐end Pipeline fitting and predicting on synthetic data. Asserts ------- - Model predictions are valid class labels and shape matches input. + Pipeline predictions are valid class labels and shape matches input. """ - # Generate dummy input X_raw = [(aptamer_seq, protein_seq) for _ in range(40)] y = np.array([0] * 20 + [1] * 20, dtype=np.float32) - # Convert sequence pairs to features - X = pairs_to_features(X_raw) - - # Initialize model - net = SkorchAptaNet( - module__hidden_dim=64, - module__n_hidden=3, - module__dropout=0.2, - max_epochs=5, - batch_size=10, - device="cuda" if torch.cuda.is_available() else "cpu", - verbose=0, - ) - - net.fit(X, y) - preds = net.predict(X) + pipe.fit(X_raw, y) + + preds = pipe.predict(X_raw) assert preds.shape == (40,) assert set(preds).issubset({0, 1}) From 1ac72fcb98998320ca4e88628e002aadcf7fdc6f Mon Sep 17 00:00:00 2001 From: satvshr Date: Tue, 29 Jul 2025 19:28:52 +0530 Subject: [PATCH 058/145] Renamed function --- pyaptamer/datasets/tests/test_pfoa.py | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/pyaptamer/datasets/tests/test_pfoa.py b/pyaptamer/datasets/tests/test_pfoa.py index 12f2ae16..0ba29de1 100644 --- a/pyaptamer/datasets/tests/test_pfoa.py +++ b/pyaptamer/datasets/tests/test_pfoa.py @@ -3,7 +3,7 @@ from pyaptamer.datasets.loader import load_pfoa_structure -def test_load_pfoa_structure_runs_and_returns_structure(): +def test_pfoa_loader(): """ Test that the load_pfoa_structure function runs without error and returns a valid Structure object. From 0d16e135a5e5d5a879cb8dc38bb43750612df41e Mon Sep 17 00:00:00 2001 From: satvshr Date: Tue, 29 Jul 2025 19:32:39 +0530 Subject: [PATCH 059/145] Stop tracking .vscode folder --- .vscode/settings.json | 5 ----- 1 file changed, 5 deletions(-) delete mode 100644 .vscode/settings.json diff --git a/.vscode/settings.json b/.vscode/settings.json deleted file mode 100644 index a8c20032..00000000 --- a/.vscode/settings.json +++ /dev/null @@ -1,5 +0,0 @@ -{ - "python-envs.defaultEnvManager": "ms-python.python:conda", - "python-envs.defaultPackageManager": "ms-python.python:conda", - "python-envs.pythonProjects": [] -} \ No newline at end of file From a38f70b7acd52654b3adf33a4cfd5dc2c7ec5321 Mon Sep 17 00:00:00 2001 From: satvshr Date: Tue, 29 Jul 2025 19:33:50 +0530 Subject: [PATCH 060/145] Stop tracking .vscode folder --- .vscode/settings.json | 5 ----- 1 file changed, 5 deletions(-) delete mode 100644 .vscode/settings.json diff --git a/.vscode/settings.json b/.vscode/settings.json deleted file mode 100644 index a8c20032..00000000 --- a/.vscode/settings.json +++ /dev/null @@ -1,5 +0,0 @@ -{ - "python-envs.defaultEnvManager": "ms-python.python:conda", - "python-envs.defaultPackageManager": "ms-python.python:conda", - "python-envs.pythonProjects": [] -} \ No newline at end of file From 40ba9d3530ae7c053dd8dde2072c0338c73d01e1 Mon Sep 17 00:00:00 2001 From: satvshr Date: Wed, 30 Jul 2025 18:30:47 +0530 Subject: [PATCH 061/145] Added 3eiy and its loader, standardized loader tests --- pyaptamer/datasets/data/3eiy.pdb | 2149 +++++++++++++++++ pyaptamer/datasets/loader/__init__.py | 3 +- pyaptamer/datasets/loader/three_eiy_loader.py | 25 + pyaptamer/datasets/tests/test_loaders.py | 23 + pyaptamer/datasets/tests/test_pfoa.py | 20 - x.py | 4 + 6 files changed, 2203 insertions(+), 21 deletions(-) create mode 100644 pyaptamer/datasets/data/3eiy.pdb create mode 100644 pyaptamer/datasets/loader/three_eiy_loader.py create mode 100644 pyaptamer/datasets/tests/test_loaders.py delete mode 100644 pyaptamer/datasets/tests/test_pfoa.py create mode 100644 x.py diff --git a/pyaptamer/datasets/data/3eiy.pdb b/pyaptamer/datasets/data/3eiy.pdb new file mode 100644 index 00000000..bdb9625a --- /dev/null +++ b/pyaptamer/datasets/data/3eiy.pdb @@ -0,0 +1,2149 @@ +HEADER HYDROLASE 17-SEP-08 3EIY +TITLE CRYSTAL STRUCTURE OF INORGANIC PYROPHOSPHATASE FROM BURKHOLDERIA +TITLE 2 PSEUDOMALLEI WITH BOUND PYROPHOSPHATE +COMPND MOL_ID: 1; +COMPND 2 MOLECULE: INORGANIC PYROPHOSPHATASE; +COMPND 3 CHAIN: A; +COMPND 4 EC: 3.6.1.1; +COMPND 5 ENGINEERED: YES +SOURCE MOL_ID: 1; +SOURCE 2 ORGANISM_SCIENTIFIC: BURKHOLDERIA PSEUDOMALLEI 1710B; +SOURCE 3 ORGANISM_TAXID: 320372; +SOURCE 4 GENE: PPA, BURPS1710B_1237; +SOURCE 5 EXPRESSION_SYSTEM: ESCHERICHIA COLI; +SOURCE 6 EXPRESSION_SYSTEM_TAXID: 562; +SOURCE 7 EXPRESSION_SYSTEM_STRAIN: BL21(DE3); +SOURCE 8 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; +SOURCE 9 EXPRESSION_SYSTEM_PLASMID: AVA0421 +KEYWDS STRUCTURAL GENOMICS, SSGCID, PYROPHOSPHATASE, HYDROLASE, +KEYWDS 2 BUPSA.00023.A, SEATTLE STRUCTURAL GENOMICS CENTER FOR INFECTIOUS +KEYWDS 3 DISEASE' +EXPDTA X-RAY DIFFRACTION +AUTHOR SEATTLE STRUCTURAL GENOMICS CENTER FOR INFECTIOUS DISEASE (SSGCID) +REVDAT 5 21-FEB-24 3EIY 1 REMARK LINK +REVDAT 4 23-OCT-13 3EIY 1 REMARK +REVDAT 3 05-OCT-11 3EIY 1 JRNL VERSN +REVDAT 2 24-FEB-09 3EIY 1 VERSN +REVDAT 1 30-SEP-08 3EIY 0 +JRNL AUTH W.C.VAN VOORHIS,W.G.HOL,P.J.MYLER,L.J.STEWART +JRNL TITL THE ROLE OF MEDICAL STRUCTURAL GENOMICS IN DISCOVERING NEW +JRNL TITL 2 DRUGS FOR INFECTIOUS DISEASES. +JRNL REF PLOS COMPUT BIOL V. 5 00530 2009 +JRNL REFN ISSN 1553-734X +JRNL PMID 19855826 +JRNL DOI 10.1371/JOURNAL.PCBI.1000530 +REMARK 1 +REMARK 1 REFERENCE 1 +REMARK 1 AUTH L.BAUGH,L.A.GALLAGHER,R.PATRAPUVICH,M.C.CLIFTON, +REMARK 1 AUTH 2 A.S.GARDBERG,T.E.EDWARDS,B.ARMOUR,D.W.BEGLEY,S.H.DIETERICH, +REMARK 1 AUTH 3 D.M.DRANOW,J.ABENDROTH,J.W.FAIRMAN,D.FOX,B.L.STAKER,I.PHAN, +REMARK 1 AUTH 4 A.GILLESPIE,R.CHOI,S.NAKAZAWA-HEWITT,M.T.NGUYEN,A.NAPULI, +REMARK 1 AUTH 5 L.BARRETT,G.W.BUCHKO,R.STACY,P.J.MYLER,L.J.STEWART,C.MANOIL, +REMARK 1 AUTH 6 W.C.VAN VOORHIS +REMARK 1 TITL COMBINING FUNCTIONAL AND STRUCTURAL GENOMICS TO SAMPLE THE +REMARK 1 TITL 2 ESSENTIAL BURKHOLDERIA STRUCTOME. +REMARK 1 REF PLOS ONE V. 8 53851 2013 +REMARK 1 REFN ESSN 1932-6203 +REMARK 1 PMID 23382856 +REMARK 1 DOI 10.1371/JOURNAL.PONE.0053851 +REMARK 2 +REMARK 2 RESOLUTION. 2.10 ANGSTROMS. +REMARK 3 +REMARK 3 REFINEMENT. +REMARK 3 PROGRAM : REFMAC 5.4.0067 +REMARK 3 AUTHORS : MURSHUDOV,SKUBAK,LEBEDEV,PANNU,STEINER, +REMARK 3 : NICHOLLS,WINN,LONG,VAGIN +REMARK 3 +REMARK 3 REFINEMENT TARGET : MAXIMUM LIKELIHOOD +REMARK 3 +REMARK 3 DATA USED IN REFINEMENT. +REMARK 3 RESOLUTION RANGE HIGH (ANGSTROMS) : 2.10 +REMARK 3 RESOLUTION RANGE LOW (ANGSTROMS) : 50.00 +REMARK 3 DATA CUTOFF (SIGMA(F)) : 0.000 +REMARK 3 COMPLETENESS FOR RANGE (%) : NULL +REMARK 3 NUMBER OF REFLECTIONS : 19547 +REMARK 3 +REMARK 3 FIT TO DATA USED IN REFINEMENT. +REMARK 3 CROSS-VALIDATION METHOD : THROUGHOUT +REMARK 3 FREE R VALUE TEST SET SELECTION : RANDOM +REMARK 3 R VALUE (WORKING + TEST SET) : 0.213 +REMARK 3 R VALUE (WORKING SET) : 0.211 +REMARK 3 FREE R VALUE : 0.249 +REMARK 3 FREE R VALUE TEST SET SIZE (%) : 5.100 +REMARK 3 FREE R VALUE TEST SET COUNT : 991 +REMARK 3 +REMARK 3 FIT IN THE HIGHEST RESOLUTION BIN. +REMARK 3 TOTAL NUMBER OF BINS USED : 20 +REMARK 3 BIN RESOLUTION RANGE HIGH (A) : 2.10 +REMARK 3 BIN RESOLUTION RANGE LOW (A) : 2.15 +REMARK 3 REFLECTION IN BIN (WORKING SET) : 1250 +REMARK 3 BIN COMPLETENESS (WORKING+TEST) (%) : 90.60 +REMARK 3 BIN R VALUE (WORKING SET) : 0.3090 +REMARK 3 BIN FREE R VALUE SET COUNT : 71 +REMARK 3 BIN FREE R VALUE : 0.4070 +REMARK 3 +REMARK 3 NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT. +REMARK 3 PROTEIN ATOMS : 1330 +REMARK 3 NUCLEIC ACID ATOMS : 0 +REMARK 3 HETEROGEN ATOMS : 39 +REMARK 3 SOLVENT ATOMS : 112 +REMARK 3 +REMARK 3 B VALUES. +REMARK 3 FROM WILSON PLOT (A**2) : NULL +REMARK 3 MEAN B VALUE (OVERALL, A**2) : 30.12 +REMARK 3 OVERALL ANISOTROPIC B VALUE. +REMARK 3 B11 (A**2) : 0.80000 +REMARK 3 B22 (A**2) : 0.80000 +REMARK 3 B33 (A**2) : -1.21000 +REMARK 3 B12 (A**2) : 0.40000 +REMARK 3 B13 (A**2) : 0.00000 +REMARK 3 B23 (A**2) : 0.00000 +REMARK 3 +REMARK 3 ESTIMATED OVERALL COORDINATE ERROR. +REMARK 3 ESU BASED ON R VALUE (A): 0.156 +REMARK 3 ESU BASED ON FREE R VALUE (A): 0.152 +REMARK 3 ESU BASED ON MAXIMUM LIKELIHOOD (A): 0.110 +REMARK 3 ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 4.164 +REMARK 3 +REMARK 3 CORRELATION COEFFICIENTS. +REMARK 3 CORRELATION COEFFICIENT FO-FC : 0.948 +REMARK 3 CORRELATION COEFFICIENT FO-FC FREE : 0.929 +REMARK 3 +REMARK 3 RMS DEVIATIONS FROM IDEAL VALUES COUNT RMS WEIGHT +REMARK 3 BOND LENGTHS REFINED ATOMS (A): 1393 ; 0.015 ; 0.022 +REMARK 3 BOND LENGTHS OTHERS (A): NULL ; NULL ; NULL +REMARK 3 BOND ANGLES REFINED ATOMS (DEGREES): 1886 ; 1.460 ; 1.994 +REMARK 3 BOND ANGLES OTHERS (DEGREES): NULL ; NULL ; NULL +REMARK 3 TORSION ANGLES, PERIOD 1 (DEGREES): 173 ; 5.857 ; 5.000 +REMARK 3 TORSION ANGLES, PERIOD 2 (DEGREES): 56 ;32.570 ;25.357 +REMARK 3 TORSION ANGLES, PERIOD 3 (DEGREES): 222 ;15.203 ;15.000 +REMARK 3 TORSION ANGLES, PERIOD 4 (DEGREES): 4 ;18.890 ;15.000 +REMARK 3 CHIRAL-CENTER RESTRAINTS (A**3): 209 ; 0.092 ; 0.200 +REMARK 3 GENERAL PLANES REFINED ATOMS (A): 1034 ; 0.007 ; 0.021 +REMARK 3 GENERAL PLANES OTHERS (A): NULL ; NULL ; NULL +REMARK 3 NON-BONDED CONTACTS REFINED ATOMS (A): NULL ; NULL ; NULL +REMARK 3 NON-BONDED CONTACTS OTHERS (A): NULL ; NULL ; NULL +REMARK 3 NON-BONDED TORSION REFINED ATOMS (A): NULL ; NULL ; NULL +REMARK 3 NON-BONDED TORSION OTHERS (A): NULL ; NULL ; NULL +REMARK 3 H-BOND (X...Y) REFINED ATOMS (A): NULL ; NULL ; NULL +REMARK 3 H-BOND (X...Y) OTHERS (A): NULL ; NULL ; NULL +REMARK 3 POTENTIAL METAL-ION REFINED ATOMS (A): NULL ; NULL ; NULL +REMARK 3 POTENTIAL METAL-ION OTHERS (A): NULL ; NULL ; NULL +REMARK 3 SYMMETRY VDW REFINED ATOMS (A): NULL ; NULL ; NULL +REMARK 3 SYMMETRY VDW OTHERS (A): NULL ; NULL ; NULL +REMARK 3 SYMMETRY H-BOND REFINED ATOMS (A): NULL ; NULL ; NULL +REMARK 3 SYMMETRY H-BOND OTHERS (A): NULL ; NULL ; NULL +REMARK 3 SYMMETRY METAL-ION REFINED ATOMS (A): NULL ; NULL ; NULL +REMARK 3 SYMMETRY METAL-ION OTHERS (A): NULL ; NULL ; NULL +REMARK 3 +REMARK 3 ISOTROPIC THERMAL FACTOR RESTRAINTS. COUNT RMS WEIGHT +REMARK 3 MAIN-CHAIN BOND REFINED ATOMS (A**2): 870 ; 0.890 ; 1.500 +REMARK 3 MAIN-CHAIN BOND OTHER ATOMS (A**2): NULL ; NULL ; NULL +REMARK 3 MAIN-CHAIN ANGLE REFINED ATOMS (A**2): 1408 ; 1.604 ; 2.000 +REMARK 3 MAIN-CHAIN ANGLE OTHER ATOMS (A**2): NULL ; NULL ; NULL +REMARK 3 SIDE-CHAIN BOND REFINED ATOMS (A**2): 523 ; 2.198 ; 3.000 +REMARK 3 SIDE-CHAIN BOND OTHER ATOMS (A**2): NULL ; NULL ; NULL +REMARK 3 SIDE-CHAIN ANGLE REFINED ATOMS (A**2): 478 ; 3.551 ; 4.500 +REMARK 3 SIDE-CHAIN ANGLE OTHER ATOMS (A**2): NULL ; NULL ; NULL +REMARK 3 LONG RANGE B REFINED ATOMS (A**2): NULL ; NULL ; NULL +REMARK 3 LONG RANGE B OTHER ATOMS (A**2): NULL ; NULL ; NULL +REMARK 3 +REMARK 3 ANISOTROPIC THERMAL FACTOR RESTRAINTS. COUNT RMS WEIGHT +REMARK 3 RIGID-BOND RESTRAINTS (A**2): NULL ; NULL ; NULL +REMARK 3 SPHERICITY; FREE ATOMS (A**2): NULL ; NULL ; NULL +REMARK 3 SPHERICITY; BONDED ATOMS (A**2): NULL ; NULL ; NULL +REMARK 3 +REMARK 3 NCS RESTRAINTS STATISTICS +REMARK 3 NUMBER OF DIFFERENT NCS GROUPS : NULL +REMARK 3 +REMARK 3 TLS DETAILS +REMARK 3 NUMBER OF TLS GROUPS : NULL +REMARK 3 +REMARK 3 BULK SOLVENT MODELLING. +REMARK 3 METHOD USED : MASK +REMARK 3 PARAMETERS FOR MASK CALCULATION +REMARK 3 VDW PROBE RADIUS : 1.20 +REMARK 3 ION PROBE RADIUS : 0.80 +REMARK 3 SHRINKAGE RADIUS : 0.80 +REMARK 3 +REMARK 3 OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN ADDED IN THE RIDING +REMARK 3 POSITIONS +REMARK 4 +REMARK 4 3EIY COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 +REMARK 100 +REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 18-SEP-08. +REMARK 100 THE DEPOSITION ID IS D_1000049380. +REMARK 200 +REMARK 200 EXPERIMENTAL DETAILS +REMARK 200 EXPERIMENT TYPE : X-RAY DIFFRACTION +REMARK 200 DATE OF DATA COLLECTION : 04-SEP-08 +REMARK 200 TEMPERATURE (KELVIN) : 100.0 +REMARK 200 PH : 6.30 +REMARK 200 NUMBER OF CRYSTALS USED : 1 +REMARK 200 +REMARK 200 SYNCHROTRON (Y/N) : N +REMARK 200 RADIATION SOURCE : ROTATING ANODE +REMARK 200 BEAMLINE : NULL +REMARK 200 X-RAY GENERATOR MODEL : RIGAKU MICROMAX-007 HF +REMARK 200 MONOCHROMATIC OR LAUE (M/L) : M +REMARK 200 WAVELENGTH OR RANGE (A) : 1.5418 +REMARK 200 MONOCHROMATOR : NULL +REMARK 200 OPTICS : NULL +REMARK 200 +REMARK 200 DETECTOR TYPE : CCD +REMARK 200 DETECTOR MANUFACTURER : RIGAKU SATURN 944 +REMARK 200 INTENSITY-INTEGRATION SOFTWARE : HKL-2000 +REMARK 200 DATA SCALING SOFTWARE : HKL-2000 +REMARK 200 +REMARK 200 NUMBER OF UNIQUE REFLECTIONS : 19792 +REMARK 200 RESOLUTION RANGE HIGH (A) : 2.100 +REMARK 200 RESOLUTION RANGE LOW (A) : 50.000 +REMARK 200 REJECTION CRITERIA (SIGMA(I)) : NULL +REMARK 200 +REMARK 200 OVERALL. +REMARK 200 COMPLETENESS FOR RANGE (%) : 98.7 +REMARK 200 DATA REDUNDANCY : 3.600 +REMARK 200 R MERGE (I) : 0.10300 +REMARK 200 R SYM (I) : NULL +REMARK 200 FOR THE DATA SET : 8.9000 +REMARK 200 +REMARK 200 IN THE HIGHEST RESOLUTION SHELL. +REMARK 200 HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.10 +REMARK 200 HIGHEST RESOLUTION SHELL, RANGE LOW (A) : 2.18 +REMARK 200 COMPLETENESS FOR SHELL (%) : 98.5 +REMARK 200 DATA REDUNDANCY IN SHELL : 2.70 +REMARK 200 R MERGE FOR SHELL (I) : 0.66900 +REMARK 200 R SYM FOR SHELL (I) : NULL +REMARK 200 FOR SHELL : NULL +REMARK 200 +REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH +REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT +REMARK 200 SOFTWARE USED: MOLREP +REMARK 200 STARTING MODEL: NULL +REMARK 200 +REMARK 200 REMARK: NULL +REMARK 280 +REMARK 280 CRYSTAL +REMARK 280 SOLVENT CONTENT, VS (%): 67.71 +REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 3.81 +REMARK 280 +REMARK 280 CRYSTALLIZATION CONDITIONS: 100 MM NA/K PHOSPHATE, PH 6.3, 49.5% +REMARK 280 PEG 200. CRYSTAL 3 MONTHS OLD., PH 6.30, VAPOR DIFFUSION, +REMARK 280 SITTING DROP, TEMPERATURE 289K +REMARK 290 +REMARK 290 CRYSTALLOGRAPHIC SYMMETRY +REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 63 2 2 +REMARK 290 +REMARK 290 SYMOP SYMMETRY +REMARK 290 NNNMMM OPERATOR +REMARK 290 1555 X,Y,Z +REMARK 290 2555 -Y,X-Y,Z +REMARK 290 3555 -X+Y,-X,Z +REMARK 290 4555 -X,-Y,Z+1/2 +REMARK 290 5555 Y,-X+Y,Z+1/2 +REMARK 290 6555 X-Y,X,Z+1/2 +REMARK 290 7555 Y,X,-Z +REMARK 290 8555 X-Y,-Y,-Z +REMARK 290 9555 -X,-X+Y,-Z +REMARK 290 10555 -Y,-X,-Z+1/2 +REMARK 290 11555 -X+Y,Y,-Z+1/2 +REMARK 290 12555 X,X-Y,-Z+1/2 +REMARK 290 +REMARK 290 WHERE NNN -> OPERATOR NUMBER +REMARK 290 MMM -> TRANSLATION VECTOR +REMARK 290 +REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS +REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM +REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY +REMARK 290 RELATED MOLECULES. +REMARK 290 SMTRY1 1 1.000000 0.000000 0.000000 0.00000 +REMARK 290 SMTRY2 1 0.000000 1.000000 0.000000 0.00000 +REMARK 290 SMTRY3 1 0.000000 0.000000 1.000000 0.00000 +REMARK 290 SMTRY1 2 -0.500000 -0.866025 0.000000 0.00000 +REMARK 290 SMTRY2 2 0.866025 -0.500000 0.000000 0.00000 +REMARK 290 SMTRY3 2 0.000000 0.000000 1.000000 0.00000 +REMARK 290 SMTRY1 3 -0.500000 0.866025 0.000000 0.00000 +REMARK 290 SMTRY2 3 -0.866025 -0.500000 0.000000 0.00000 +REMARK 290 SMTRY3 3 0.000000 0.000000 1.000000 0.00000 +REMARK 290 SMTRY1 4 -1.000000 0.000000 0.000000 0.00000 +REMARK 290 SMTRY2 4 0.000000 -1.000000 0.000000 0.00000 +REMARK 290 SMTRY3 4 0.000000 0.000000 1.000000 55.61650 +REMARK 290 SMTRY1 5 0.500000 0.866025 0.000000 0.00000 +REMARK 290 SMTRY2 5 -0.866025 0.500000 0.000000 0.00000 +REMARK 290 SMTRY3 5 0.000000 0.000000 1.000000 55.61650 +REMARK 290 SMTRY1 6 0.500000 -0.866025 0.000000 0.00000 +REMARK 290 SMTRY2 6 0.866025 0.500000 0.000000 0.00000 +REMARK 290 SMTRY3 6 0.000000 0.000000 1.000000 55.61650 +REMARK 290 SMTRY1 7 -0.500000 0.866025 0.000000 0.00000 +REMARK 290 SMTRY2 7 0.866025 0.500000 0.000000 0.00000 +REMARK 290 SMTRY3 7 0.000000 0.000000 -1.000000 0.00000 +REMARK 290 SMTRY1 8 1.000000 0.000000 0.000000 0.00000 +REMARK 290 SMTRY2 8 0.000000 -1.000000 0.000000 0.00000 +REMARK 290 SMTRY3 8 0.000000 0.000000 -1.000000 0.00000 +REMARK 290 SMTRY1 9 -0.500000 -0.866025 0.000000 0.00000 +REMARK 290 SMTRY2 9 -0.866025 0.500000 0.000000 0.00000 +REMARK 290 SMTRY3 9 0.000000 0.000000 -1.000000 0.00000 +REMARK 290 SMTRY1 10 0.500000 -0.866025 0.000000 0.00000 +REMARK 290 SMTRY2 10 -0.866025 -0.500000 0.000000 0.00000 +REMARK 290 SMTRY3 10 0.000000 0.000000 -1.000000 55.61650 +REMARK 290 SMTRY1 11 -1.000000 0.000000 0.000000 0.00000 +REMARK 290 SMTRY2 11 0.000000 1.000000 0.000000 0.00000 +REMARK 290 SMTRY3 11 0.000000 0.000000 -1.000000 55.61650 +REMARK 290 SMTRY1 12 0.500000 0.866025 0.000000 0.00000 +REMARK 290 SMTRY2 12 0.866025 -0.500000 0.000000 0.00000 +REMARK 290 SMTRY3 12 0.000000 0.000000 -1.000000 55.61650 +REMARK 290 +REMARK 290 REMARK: NULL +REMARK 300 +REMARK 300 BIOMOLECULE: 1, 2, 3 +REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM +REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN +REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON +REMARK 300 BURIED SURFACE AREA. +REMARK 350 +REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN +REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE +REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS +REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND +REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. +REMARK 350 +REMARK 350 BIOMOLECULE: 1 +REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: HEXAMERIC +REMARK 350 SOFTWARE USED: PISA +REMARK 350 TOTAL BURIED SURFACE AREA: 20130 ANGSTROM**2 +REMARK 350 SURFACE AREA OF THE COMPLEX: 37680 ANGSTROM**2 +REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -208.0 KCAL/MOL +REMARK 350 APPLY THE FOLLOWING TO CHAINS: A +REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 +REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 +REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 +REMARK 350 BIOMT1 2 -0.500000 -0.866025 0.000000 50.47600 +REMARK 350 BIOMT2 2 0.866025 -0.500000 0.000000 87.42700 +REMARK 350 BIOMT3 2 0.000000 0.000000 1.000000 0.00000 +REMARK 350 BIOMT1 3 -0.500000 0.866025 0.000000 -50.47600 +REMARK 350 BIOMT2 3 -0.866025 -0.500000 0.000000 87.42700 +REMARK 350 BIOMT3 3 0.000000 0.000000 1.000000 0.00000 +REMARK 350 BIOMT1 4 0.500000 -0.866025 0.000000 50.47600 +REMARK 350 BIOMT2 4 -0.866025 -0.500000 0.000000 87.42700 +REMARK 350 BIOMT3 4 0.000000 0.000000 -1.000000 55.61650 +REMARK 350 BIOMT1 5 -1.000000 0.000000 0.000000 0.00000 +REMARK 350 BIOMT2 5 0.000000 1.000000 0.000000 0.00000 +REMARK 350 BIOMT3 5 0.000000 0.000000 -1.000000 55.61650 +REMARK 350 BIOMT1 6 0.500000 0.866025 0.000000 -50.47600 +REMARK 350 BIOMT2 6 0.866025 -0.500000 0.000000 87.42700 +REMARK 350 BIOMT3 6 0.000000 0.000000 -1.000000 55.61650 +REMARK 350 +REMARK 350 BIOMOLECULE: 2 +REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: TRIMERIC +REMARK 350 SOFTWARE USED: PISA +REMARK 350 TOTAL BURIED SURFACE AREA: 7740 ANGSTROM**2 +REMARK 350 SURFACE AREA OF THE COMPLEX: 21160 ANGSTROM**2 +REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -92.0 KCAL/MOL +REMARK 350 APPLY THE FOLLOWING TO CHAINS: A +REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 +REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 +REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 +REMARK 350 BIOMT1 2 -0.500000 -0.866025 0.000000 50.47600 +REMARK 350 BIOMT2 2 0.866025 -0.500000 0.000000 87.42700 +REMARK 350 BIOMT3 2 0.000000 0.000000 1.000000 0.00000 +REMARK 350 BIOMT1 3 -0.500000 0.866025 0.000000 -50.47600 +REMARK 350 BIOMT2 3 -0.866025 -0.500000 0.000000 87.42700 +REMARK 350 BIOMT3 3 0.000000 0.000000 1.000000 0.00000 +REMARK 350 +REMARK 350 BIOMOLECULE: 3 +REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC +REMARK 350 APPLY THE FOLLOWING TO CHAINS: A +REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 +REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 +REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 +REMARK 375 +REMARK 375 SPECIAL POSITION +REMARK 375 THE FOLLOWING ATOMS ARE FOUND TO BE WITHIN 0.15 ANGSTROMS +REMARK 375 OF A SYMMETRY RELATED ATOM AND ARE ASSUMED TO BE ON SPECIAL +REMARK 375 POSITIONS. +REMARK 375 +REMARK 375 ATOM RES CSSEQI +REMARK 375 K K A 176 LIES ON A SPECIAL POSITION. +REMARK 465 +REMARK 465 MISSING RESIDUES +REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE +REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN +REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) +REMARK 465 +REMARK 465 M RES C SSSEQI +REMARK 465 MET A -20 +REMARK 465 ALA A -19 +REMARK 465 HIS A -18 +REMARK 465 HIS A -17 +REMARK 465 HIS A -16 +REMARK 465 HIS A -15 +REMARK 465 HIS A -14 +REMARK 465 HIS A -13 +REMARK 465 MET A -12 +REMARK 465 GLY A -11 +REMARK 465 THR A -10 +REMARK 465 LEU A -9 +REMARK 465 GLU A -8 +REMARK 465 ALA A -7 +REMARK 465 GLN A -6 +REMARK 465 THR A -5 +REMARK 465 GLN A -4 +REMARK 465 GLY A -3 +REMARK 465 PRO A -2 +REMARK 465 GLY A -1 +REMARK 465 SER A 0 +REMARK 465 MET A 1 +REMARK 470 +REMARK 470 MISSING ATOM +REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER; +REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; +REMARK 470 I=INSERTION CODE): +REMARK 470 M RES CSSEQI ATOMS +REMARK 470 LYS A 113 CG CD CE NZ +REMARK 470 LYS A 147 CG CD CE NZ +REMARK 470 LYS A 152 CG CD CE NZ +REMARK 500 +REMARK 500 GEOMETRY AND STEREOCHEMISTRY +REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT +REMARK 500 +REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT. +REMARK 500 +REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE +REMARK 500 O HOH A 238 O HOH A 281 2.06 +REMARK 500 +REMARK 500 REMARK: NULL +REMARK 500 +REMARK 500 GEOMETRY AND STEREOCHEMISTRY +REMARK 500 SUBTOPIC: TORSION ANGLES +REMARK 500 +REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: +REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; +REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). +REMARK 500 +REMARK 500 STANDARD TABLE: +REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) +REMARK 500 +REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- +REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 +REMARK 500 +REMARK 500 M RES CSSEQI PSI PHI +REMARK 500 ASP A 11 81.33 -159.79 +REMARK 500 ASP A 98 -168.63 -122.40 +REMARK 500 +REMARK 500 REMARK: NULL +REMARK 620 +REMARK 620 METAL COORDINATION +REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; +REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE): +REMARK 620 +REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL +REMARK 620 K A 176 K +REMARK 620 N RES CSSEQI ATOM +REMARK 620 1 ASP A 11 OD1 +REMARK 620 2 LEU A 12 O 92.8 +REMARK 620 3 GLN A 14 OE1 100.9 87.2 +REMARK 620 N 1 2 +REMARK 620 +REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL +REMARK 620 NA A 178 NA +REMARK 620 N RES CSSEQI ATOM +REMARK 620 1 ASP A 71 OD2 +REMARK 620 2 ASP A 103 OD1 94.9 +REMARK 620 3 ALA A 104 O 102.5 85.4 +REMARK 620 4 HOH A 245 O 72.2 146.6 127.0 +REMARK 620 5 HOH A 247 O 169.6 95.4 79.9 98.2 +REMARK 620 6 HOH A 263 O 85.2 155.0 70.3 56.8 86.0 +REMARK 620 N 1 2 3 4 5 +REMARK 620 +REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL +REMARK 620 NA A 177 NA +REMARK 620 N RES CSSEQI ATOM +REMARK 620 1 ASP A 98 OD2 +REMARK 620 2 ASP A 103 OD2 91.4 +REMARK 620 3 POP A 179 O6 93.1 172.2 +REMARK 620 4 POP A 179 O3 165.9 100.0 76.6 +REMARK 620 5 HOH A 201 O 89.4 88.0 85.7 99.2 +REMARK 620 6 HOH A 257 O 78.3 74.9 112.2 96.5 158.6 +REMARK 620 N 1 2 3 4 5 +REMARK 800 +REMARK 800 SITE +REMARK 800 SITE_IDENTIFIER: AC1 +REMARK 800 EVIDENCE_CODE: SOFTWARE +REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE K A 176 +REMARK 800 +REMARK 800 SITE_IDENTIFIER: AC2 +REMARK 800 EVIDENCE_CODE: SOFTWARE +REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NA A 177 +REMARK 800 +REMARK 800 SITE_IDENTIFIER: AC3 +REMARK 800 EVIDENCE_CODE: SOFTWARE +REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NA A 178 +REMARK 800 +REMARK 800 SITE_IDENTIFIER: AC4 +REMARK 800 EVIDENCE_CODE: SOFTWARE +REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE POP A 179 +REMARK 800 +REMARK 800 SITE_IDENTIFIER: AC5 +REMARK 800 EVIDENCE_CODE: SOFTWARE +REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE PG4 A 180 +REMARK 800 +REMARK 800 SITE_IDENTIFIER: AC6 +REMARK 800 EVIDENCE_CODE: SOFTWARE +REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE PEG A 181 +REMARK 800 +REMARK 800 SITE_IDENTIFIER: AC7 +REMARK 800 EVIDENCE_CODE: SOFTWARE +REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE PEG A 182 +REMARK 900 +REMARK 900 RELATED ENTRIES +REMARK 900 RELATED ID: BUPSA.00023.A RELATED DB: TARGETDB +REMARK 900 RELATED ID: 3D63 RELATED DB: PDB +REMARK 900 THE SAME PROTEIN, "OPEN" CONFORMATION, APO FORM, IN SPACE GROUP +REMARK 900 P21212 +REMARK 900 RELATED ID: 3EIZ RELATED DB: PDB +REMARK 900 RELATED ID: 3EJ0 RELATED DB: PDB +REMARK 900 RELATED ID: 3EJ2 RELATED DB: PDB +DBREF 3EIY A 1 175 UNP Q3JUV5 Q3JUV5_BURP1 1 175 +SEQADV 3EIY MET A -20 UNP Q3JUV5 EXPRESSION TAG +SEQADV 3EIY ALA A -19 UNP Q3JUV5 EXPRESSION TAG +SEQADV 3EIY HIS A -18 UNP Q3JUV5 EXPRESSION TAG +SEQADV 3EIY HIS A -17 UNP Q3JUV5 EXPRESSION TAG +SEQADV 3EIY HIS A -16 UNP Q3JUV5 EXPRESSION TAG +SEQADV 3EIY HIS A -15 UNP Q3JUV5 EXPRESSION TAG +SEQADV 3EIY HIS A -14 UNP Q3JUV5 EXPRESSION TAG +SEQADV 3EIY HIS A -13 UNP Q3JUV5 EXPRESSION TAG +SEQADV 3EIY MET A -12 UNP Q3JUV5 EXPRESSION TAG +SEQADV 3EIY GLY A -11 UNP Q3JUV5 EXPRESSION TAG +SEQADV 3EIY THR A -10 UNP Q3JUV5 EXPRESSION TAG +SEQADV 3EIY LEU A -9 UNP Q3JUV5 EXPRESSION TAG +SEQADV 3EIY GLU A -8 UNP Q3JUV5 EXPRESSION TAG +SEQADV 3EIY ALA A -7 UNP Q3JUV5 EXPRESSION TAG +SEQADV 3EIY GLN A -6 UNP Q3JUV5 EXPRESSION TAG +SEQADV 3EIY THR A -5 UNP Q3JUV5 EXPRESSION TAG +SEQADV 3EIY GLN A -4 UNP Q3JUV5 EXPRESSION TAG +SEQADV 3EIY GLY A -3 UNP Q3JUV5 EXPRESSION TAG +SEQADV 3EIY PRO A -2 UNP Q3JUV5 EXPRESSION TAG +SEQADV 3EIY GLY A -1 UNP Q3JUV5 EXPRESSION TAG +SEQADV 3EIY SER A 0 UNP Q3JUV5 EXPRESSION TAG +SEQRES 1 A 196 MET ALA HIS HIS HIS HIS HIS HIS MET GLY THR LEU GLU +SEQRES 2 A 196 ALA GLN THR GLN GLY PRO GLY SER MET SER PHE SER ASN +SEQRES 3 A 196 VAL PRO ALA GLY LYS ASP LEU PRO GLN ASP PHE ASN VAL +SEQRES 4 A 196 ILE ILE GLU ILE PRO ALA GLN SER GLU PRO VAL LYS TYR +SEQRES 5 A 196 GLU ALA ASP LYS ALA LEU GLY LEU LEU VAL VAL ASP ARG +SEQRES 6 A 196 PHE ILE GLY THR GLY MET ARG TYR PRO VAL ASN TYR GLY +SEQRES 7 A 196 PHE ILE PRO GLN THR LEU SER GLY ASP GLY ASP PRO VAL +SEQRES 8 A 196 ASP VAL LEU VAL ILE THR PRO PHE PRO LEU LEU ALA GLY +SEQRES 9 A 196 SER VAL VAL ARG ALA ARG ALA LEU GLY MET LEU LYS MET +SEQRES 10 A 196 THR ASP GLU SER GLY VAL ASP ALA LYS LEU VAL ALA VAL +SEQRES 11 A 196 PRO HIS ASP LYS VAL CYS PRO MET THR ALA ASN LEU LYS +SEQRES 12 A 196 SER ILE ASP ASP VAL PRO ALA TYR LEU LYS ASP GLN ILE +SEQRES 13 A 196 LYS HIS PHE PHE GLU GLN TYR LYS ALA LEU GLU LYS GLY +SEQRES 14 A 196 LYS TRP VAL LYS VAL GLU GLY TRP ASP GLY ILE ASP ALA +SEQRES 15 A 196 ALA HIS LYS GLU ILE THR ASP GLY VAL ALA ASN PHE LYS +SEQRES 16 A 196 LYS +HET K A 176 1 +HET NA A 177 1 +HET NA A 178 1 +HET POP A 179 9 +HET PG4 A 180 13 +HET PEG A 181 7 +HET PEG A 182 7 +HETNAM K POTASSIUM ION +HETNAM NA SODIUM ION +HETNAM POP PYROPHOSPHATE 2- +HETNAM PG4 TETRAETHYLENE GLYCOL +HETNAM PEG DI(HYDROXYETHYL)ETHER +FORMUL 2 K K 1+ +FORMUL 3 NA 2(NA 1+) +FORMUL 5 POP H2 O7 P2 2- +FORMUL 6 PG4 C8 H18 O5 +FORMUL 7 PEG 2(C4 H10 O3) +FORMUL 9 HOH *112(H2 O) +HELIX 1 1 SER A 2 VAL A 6 5 5 +HELIX 2 2 CYS A 115 ALA A 119 5 5 +HELIX 3 3 SER A 123 VAL A 127 5 5 +HELIX 4 4 PRO A 128 TYR A 142 1 15 +HELIX 5 5 GLY A 158 LYS A 175 1 18 +SHEET 1 A 7 VAL A 151 ASP A 157 0 +SHEET 2 A 7 VAL A 85 ASP A 98 -1 N LYS A 95 O GLY A 155 +SHEET 3 A 7 GLY A 101 PRO A 110 -1 O LYS A 105 N LEU A 94 +SHEET 4 A 7 VAL A 70 VAL A 74 1 N LEU A 73 O ALA A 108 +SHEET 5 A 7 ASN A 55 ILE A 59 -1 N GLY A 57 O VAL A 72 +SHEET 6 A 7 PHE A 16 ILE A 22 -1 N ILE A 19 O PHE A 58 +SHEET 7 A 7 VAL A 85 ASP A 98 -1 O ALA A 88 N PHE A 16 +SHEET 1 B 2 VAL A 29 ASP A 34 0 +SHEET 2 B 2 LEU A 39 PHE A 45 -1 O LEU A 39 N ASP A 34 +LINK OD1 ASP A 11 K K A 176 1555 1555 2.73 +LINK O LEU A 12 K K A 176 1555 1555 2.65 +LINK OE1 GLN A 14 K K A 176 1555 1555 2.92 +LINK OD2 ASP A 71 NA NA A 178 1555 1555 2.81 +LINK OD2 ASP A 98 NA NA A 177 1555 1555 2.65 +LINK OD2 ASP A 103 NA NA A 177 1555 1555 2.58 +LINK OD1 ASP A 103 NA NA A 178 1555 1555 2.53 +LINK O ALA A 104 NA NA A 178 1555 1555 2.92 +LINK NA NA A 177 O6 POP A 179 1555 1555 2.56 +LINK NA NA A 177 O3 POP A 179 1555 1555 2.20 +LINK NA NA A 177 O HOH A 201 1555 1555 2.50 +LINK NA NA A 177 O HOH A 257 1555 1555 2.65 +LINK NA NA A 178 O HOH A 245 1555 1555 2.66 +LINK NA NA A 178 O HOH A 247 1555 1555 2.86 +LINK NA NA A 178 O HOH A 263 1555 1555 2.50 +CISPEP 1 LEU A 12 PRO A 13 0 -0.44 +SITE 1 AC1 3 ASP A 11 LEU A 12 GLN A 14 +SITE 1 AC2 6 ASP A 98 ASP A 103 LYS A 143 POP A 179 +SITE 2 AC2 6 HOH A 201 HOH A 257 +SITE 1 AC3 7 ASP A 66 ASP A 71 ASP A 103 ALA A 104 +SITE 2 AC3 7 HOH A 245 HOH A 247 HOH A 263 +SITE 1 AC4 14 LYS A 30 ARG A 44 TYR A 56 ASP A 103 +SITE 2 AC4 14 LYS A 105 TYR A 142 LYS A 143 NA A 177 +SITE 3 AC4 14 HOH A 200 HOH A 221 HOH A 238 HOH A 239 +SITE 4 AC4 14 HOH A 260 HOH A 267 +SITE 1 AC5 7 GLY A 9 LYS A 10 ASP A 11 LEU A 12 +SITE 2 AC5 7 GLN A 14 ASP A 160 HIS A 163 +SITE 1 AC6 4 LYS A 136 VAL A 153 GLU A 154 TRP A 156 +SITE 1 AC7 3 ARG A 87 LYS A 113 VAL A 114 +CRYST1 100.952 100.952 111.233 90.00 90.00 120.00 P 63 2 2 12 +ORIGX1 1.000000 0.000000 0.000000 0.00000 +ORIGX2 0.000000 1.000000 0.000000 0.00000 +ORIGX3 0.000000 0.000000 1.000000 0.00000 +SCALE1 0.009906 0.005719 0.000000 0.00000 +SCALE2 0.000000 0.011438 0.000000 0.00000 +SCALE3 0.000000 0.000000 0.008990 0.00000 +ATOM 1 N SER A 2 2.527 54.656 -1.667 1.00 52.73 N +ATOM 2 CA SER A 2 3.259 54.783 -0.368 1.00 52.54 C +ATOM 3 C SER A 2 4.127 53.553 -0.105 1.00 52.03 C +ATOM 4 O SER A 2 5.274 53.451 -0.594 1.00 52.45 O +ATOM 5 CB SER A 2 2.273 54.944 0.792 1.00 52.69 C +ATOM 6 OG SER A 2 2.066 56.306 1.121 1.00 54.37 O +ATOM 7 N PHE A 3 3.563 52.626 0.674 1.00 50.61 N +ATOM 8 CA PHE A 3 4.261 51.413 1.102 1.00 48.73 C +ATOM 9 C PHE A 3 4.881 50.670 -0.064 1.00 48.17 C +ATOM 10 O PHE A 3 6.035 50.257 0.019 1.00 47.56 O +ATOM 11 CB PHE A 3 3.342 50.479 1.896 1.00 47.95 C +ATOM 12 CG PHE A 3 2.747 51.112 3.120 1.00 46.23 C +ATOM 13 CD1 PHE A 3 3.425 52.100 3.804 1.00 43.75 C +ATOM 14 CD2 PHE A 3 1.509 50.701 3.594 1.00 45.77 C +ATOM 15 CE1 PHE A 3 2.893 52.679 4.942 1.00 44.62 C +ATOM 16 CE2 PHE A 3 0.955 51.280 4.728 1.00 45.65 C +ATOM 17 CZ PHE A 3 1.655 52.273 5.409 1.00 45.91 C +ATOM 18 N SER A 4 4.122 50.518 -1.151 1.00 47.69 N +ATOM 19 CA SER A 4 4.593 49.745 -2.323 1.00 47.00 C +ATOM 20 C SER A 4 5.896 50.254 -2.977 1.00 45.29 C +ATOM 21 O SER A 4 6.627 49.479 -3.592 1.00 45.34 O +ATOM 22 CB SER A 4 3.489 49.633 -3.387 1.00 47.47 C +ATOM 23 OG SER A 4 3.169 50.916 -3.908 1.00 49.92 O +ATOM 24 N ASN A 5 6.184 51.544 -2.832 1.00 43.32 N +ATOM 25 CA ASN A 5 7.351 52.145 -3.480 1.00 41.42 C +ATOM 26 C ASN A 5 8.584 52.307 -2.574 1.00 39.00 C +ATOM 27 O ASN A 5 9.629 52.802 -3.000 1.00 38.69 O +ATOM 28 CB ASN A 5 6.958 53.491 -4.094 1.00 42.02 C +ATOM 29 CG ASN A 5 6.108 53.321 -5.366 1.00 45.67 C +ATOM 30 OD1 ASN A 5 4.862 53.286 -5.312 1.00 48.48 O +ATOM 31 ND2 ASN A 5 6.784 53.176 -6.513 1.00 47.35 N +ATOM 32 N VAL A 6 8.466 51.922 -1.312 1.00 35.70 N +ATOM 33 CA VAL A 6 9.636 51.959 -0.457 1.00 32.41 C +ATOM 34 C VAL A 6 10.595 50.807 -0.862 1.00 30.30 C +ATOM 35 O VAL A 6 10.176 49.658 -0.964 1.00 29.28 O +ATOM 36 CB VAL A 6 9.242 51.846 1.038 1.00 32.26 C +ATOM 37 CG1 VAL A 6 10.476 51.902 1.905 1.00 30.72 C +ATOM 38 CG2 VAL A 6 8.257 52.934 1.415 1.00 30.80 C +ATOM 39 N PRO A 7 11.890 51.109 -1.064 1.00 28.73 N +ATOM 40 CA PRO A 7 12.827 50.031 -1.447 1.00 27.85 C +ATOM 41 C PRO A 7 12.952 49.030 -0.321 1.00 26.92 C +ATOM 42 O PRO A 7 12.827 49.397 0.859 1.00 26.32 O +ATOM 43 CB PRO A 7 14.159 50.763 -1.644 1.00 27.56 C +ATOM 44 CG PRO A 7 13.784 52.193 -1.869 1.00 28.99 C +ATOM 45 CD PRO A 7 12.550 52.421 -1.016 1.00 28.59 C +ATOM 46 N ALA A 8 13.208 47.777 -0.660 1.00 26.04 N +ATOM 47 CA ALA A 8 13.463 46.785 0.378 1.00 25.67 C +ATOM 48 C ALA A 8 14.702 47.145 1.205 1.00 25.55 C +ATOM 49 O ALA A 8 14.786 46.804 2.395 1.00 25.75 O +ATOM 50 CB ALA A 8 13.588 45.395 -0.224 1.00 25.25 C +ATOM 51 N GLY A 9 15.668 47.834 0.598 1.00 25.34 N +ATOM 52 CA GLY A 9 16.864 48.237 1.344 1.00 25.46 C +ATOM 53 C GLY A 9 17.905 48.951 0.506 1.00 26.30 C +ATOM 54 O GLY A 9 17.865 48.854 -0.717 1.00 26.99 O +ATOM 55 N LYS A 10 18.834 49.654 1.159 1.00 26.15 N +ATOM 56 CA LYS A 10 19.941 50.322 0.477 1.00 27.63 C +ATOM 57 C LYS A 10 21.104 49.348 0.102 1.00 27.17 C +ATOM 58 O LYS A 10 21.920 49.640 -0.769 1.00 28.04 O +ATOM 59 CB LYS A 10 20.522 51.442 1.352 1.00 27.27 C +ATOM 60 CG LYS A 10 19.619 52.654 1.569 1.00 32.65 C +ATOM 61 CD LYS A 10 20.334 53.690 2.451 1.00 38.46 C +ATOM 62 CE LYS A 10 19.720 55.094 2.319 1.00 42.10 C +ATOM 63 NZ LYS A 10 18.235 55.016 2.421 1.00 42.82 N +ATOM 64 N ASP A 11 21.204 48.221 0.782 1.00 26.40 N +ATOM 65 CA ASP A 11 22.265 47.261 0.452 1.00 25.76 C +ATOM 66 C ASP A 11 21.901 45.893 0.979 1.00 24.71 C +ATOM 67 O ASP A 11 22.369 45.488 2.037 1.00 25.14 O +ATOM 68 CB ASP A 11 23.639 47.723 0.995 1.00 25.24 C +ATOM 69 CG ASP A 11 24.809 47.007 0.321 1.00 26.43 C +ATOM 70 OD1 ASP A 11 24.583 45.956 -0.326 1.00 25.79 O +ATOM 71 OD2 ASP A 11 25.973 47.447 0.460 1.00 27.48 O +ATOM 72 N LEU A 12 21.065 45.188 0.225 1.00 24.00 N +ATOM 73 CA LEU A 12 20.522 43.892 0.629 1.00 24.17 C +ATOM 74 C LEU A 12 21.527 42.731 0.574 1.00 24.26 C +ATOM 75 O LEU A 12 22.415 42.717 -0.279 1.00 23.90 O +ATOM 76 CB LEU A 12 19.327 43.549 -0.255 1.00 23.47 C +ATOM 77 CG LEU A 12 18.183 44.559 -0.124 1.00 24.51 C +ATOM 78 CD1 LEU A 12 17.245 44.405 -1.303 1.00 24.49 C +ATOM 79 CD2 LEU A 12 17.457 44.315 1.204 1.00 21.79 C +ATOM 80 N PRO A 13 21.386 41.743 1.476 1.00 24.36 N +ATOM 81 CA PRO A 13 20.351 41.670 2.533 1.00 24.17 C +ATOM 82 C PRO A 13 20.685 42.375 3.838 1.00 24.39 C +ATOM 83 O PRO A 13 19.834 42.426 4.711 1.00 25.43 O +ATOM 84 CB PRO A 13 20.288 40.158 2.827 1.00 23.15 C +ATOM 85 CG PRO A 13 21.729 39.721 2.577 1.00 24.50 C +ATOM 86 CD PRO A 13 22.089 40.451 1.320 1.00 23.40 C +ATOM 87 N GLN A 14 21.914 42.858 4.024 1.00 24.55 N +ATOM 88 CA GLN A 14 22.326 43.248 5.367 1.00 24.52 C +ATOM 89 C GLN A 14 21.819 44.648 5.828 1.00 24.75 C +ATOM 90 O GLN A 14 21.677 44.894 7.030 1.00 24.93 O +ATOM 91 CB GLN A 14 23.855 43.075 5.569 1.00 24.43 C +ATOM 92 CG GLN A 14 24.713 44.188 5.026 1.00 23.98 C +ATOM 93 CD GLN A 14 25.043 43.985 3.535 1.00 28.20 C +ATOM 94 OE1 GLN A 14 24.581 43.009 2.886 1.00 24.90 O +ATOM 95 NE2 GLN A 14 25.852 44.905 2.978 1.00 26.11 N +ATOM 96 N ASP A 15 21.564 45.534 4.870 1.00 23.84 N +ATOM 97 CA ASP A 15 21.118 46.909 5.116 1.00 24.38 C +ATOM 98 C ASP A 15 19.713 47.043 4.478 1.00 23.69 C +ATOM 99 O ASP A 15 19.595 47.207 3.252 1.00 24.21 O +ATOM 100 CB ASP A 15 22.139 47.858 4.480 1.00 23.38 C +ATOM 101 CG ASP A 15 21.822 49.319 4.698 1.00 26.33 C +ATOM 102 OD1 ASP A 15 20.881 49.684 5.451 1.00 27.50 O +ATOM 103 OD2 ASP A 15 22.525 50.140 4.100 1.00 26.80 O +ATOM 104 N PHE A 16 18.663 46.860 5.294 1.00 23.31 N +ATOM 105 CA PHE A 16 17.273 46.837 4.816 1.00 23.19 C +ATOM 106 C PHE A 16 16.304 47.845 5.526 1.00 23.35 C +ATOM 107 O PHE A 16 16.611 48.396 6.589 1.00 23.52 O +ATOM 108 CB PHE A 16 16.708 45.420 4.913 1.00 22.15 C +ATOM 109 CG PHE A 16 16.755 44.850 6.304 1.00 23.52 C +ATOM 110 CD1 PHE A 16 15.651 44.981 7.178 1.00 21.74 C +ATOM 111 CD2 PHE A 16 17.894 44.177 6.749 1.00 21.69 C +ATOM 112 CE1 PHE A 16 15.692 44.448 8.458 1.00 23.07 C +ATOM 113 CE2 PHE A 16 17.962 43.648 8.041 1.00 21.56 C +ATOM 114 CZ PHE A 16 16.870 43.770 8.903 1.00 22.24 C +ATOM 115 N ASN A 17 15.127 48.049 4.936 1.00 23.34 N +ATOM 116 CA ASN A 17 14.124 48.961 5.479 1.00 22.99 C +ATOM 117 C ASN A 17 12.974 48.168 6.088 1.00 22.52 C +ATOM 118 O ASN A 17 12.615 47.109 5.587 1.00 21.94 O +ATOM 119 CB ASN A 17 13.567 49.872 4.354 1.00 24.37 C +ATOM 120 CG ASN A 17 14.635 50.818 3.792 1.00 24.52 C +ATOM 121 OD1 ASN A 17 15.483 51.296 4.541 1.00 26.24 O +ATOM 122 ND2 ASN A 17 14.609 51.063 2.469 1.00 22.96 N +ATOM 123 N VAL A 18 12.406 48.688 7.175 1.00 22.23 N +ATOM 124 CA VAL A 18 11.233 48.079 7.822 1.00 20.84 C +ATOM 125 C VAL A 18 10.145 49.150 7.953 1.00 20.77 C +ATOM 126 O VAL A 18 10.375 50.259 8.466 1.00 20.23 O +ATOM 127 CB VAL A 18 11.556 47.505 9.264 1.00 21.36 C +ATOM 128 CG1 VAL A 18 10.350 46.768 9.827 1.00 19.07 C +ATOM 129 CG2 VAL A 18 12.803 46.559 9.236 1.00 19.34 C +ATOM 130 N ILE A 19 8.968 48.830 7.446 1.00 20.63 N +ATOM 131 CA ILE A 19 7.808 49.672 7.712 1.00 21.06 C +ATOM 132 C ILE A 19 7.109 49.163 8.967 1.00 20.14 C +ATOM 133 O ILE A 19 6.763 47.954 9.057 1.00 19.42 O +ATOM 134 CB ILE A 19 6.841 49.673 6.498 1.00 22.11 C +ATOM 135 CG1 ILE A 19 7.500 50.469 5.349 1.00 22.28 C +ATOM 136 CG2 ILE A 19 5.467 50.272 6.876 1.00 19.98 C +ATOM 137 CD1 ILE A 19 6.887 50.180 3.973 1.00 24.13 C +ATOM 138 N ILE A 20 6.914 50.062 9.937 1.00 19.07 N +ATOM 139 CA ILE A 20 6.335 49.641 11.228 1.00 18.73 C +ATOM 140 C ILE A 20 4.808 49.541 11.151 1.00 19.01 C +ATOM 141 O ILE A 20 4.148 50.500 10.726 1.00 20.15 O +ATOM 142 CB ILE A 20 6.767 50.609 12.367 1.00 18.68 C +ATOM 143 CG1 ILE A 20 8.310 50.664 12.407 1.00 18.52 C +ATOM 144 CG2 ILE A 20 6.131 50.202 13.761 1.00 17.94 C +ATOM 145 CD1 ILE A 20 8.972 49.240 12.614 1.00 16.95 C +ATOM 146 N GLU A 21 4.251 48.404 11.563 1.00 18.77 N +ATOM 147 CA GLU A 21 2.788 48.243 11.677 1.00 19.87 C +ATOM 148 C GLU A 21 2.290 48.373 13.130 1.00 19.89 C +ATOM 149 O GLU A 21 1.226 48.954 13.377 1.00 20.64 O +ATOM 150 CB GLU A 21 2.343 46.896 11.092 1.00 19.24 C +ATOM 151 CG GLU A 21 2.620 46.756 9.582 1.00 21.01 C +ATOM 152 CD GLU A 21 2.500 45.327 9.118 1.00 22.65 C +ATOM 153 OE1 GLU A 21 3.120 44.447 9.729 1.00 26.58 O +ATOM 154 OE2 GLU A 21 1.771 45.072 8.153 1.00 23.20 O +ATOM 155 N ILE A 22 3.076 47.870 14.079 1.00 19.73 N +ATOM 156 CA ILE A 22 2.667 47.809 15.505 1.00 19.94 C +ATOM 157 C ILE A 22 3.788 48.237 16.456 1.00 19.81 C +ATOM 158 O ILE A 22 4.767 47.517 16.605 1.00 21.37 O +ATOM 159 CB ILE A 22 2.182 46.370 15.899 1.00 20.44 C +ATOM 160 CG1 ILE A 22 1.021 45.935 15.009 1.00 19.03 C +ATOM 161 CG2 ILE A 22 1.789 46.307 17.367 1.00 19.40 C +ATOM 162 CD1 ILE A 22 0.659 44.455 15.118 1.00 19.72 C +ATOM 163 N PRO A 23 3.672 49.434 17.073 1.00 19.24 N +ATOM 164 CA PRO A 23 4.714 49.919 18.016 1.00 18.94 C +ATOM 165 C PRO A 23 4.816 48.987 19.246 1.00 19.28 C +ATOM 166 O PRO A 23 3.819 48.398 19.666 1.00 19.56 O +ATOM 167 CB PRO A 23 4.201 51.308 18.436 1.00 18.92 C +ATOM 168 CG PRO A 23 3.286 51.728 17.295 1.00 17.76 C +ATOM 169 CD PRO A 23 2.608 50.421 16.861 1.00 17.40 C +ATOM 170 N ALA A 24 6.026 48.803 19.761 1.00 18.68 N +ATOM 171 CA ALA A 24 6.227 48.079 21.006 1.00 18.54 C +ATOM 172 C ALA A 24 5.270 48.569 22.090 1.00 18.10 C +ATOM 173 O ALA A 24 5.137 49.785 22.277 1.00 18.29 O +ATOM 174 CB ALA A 24 7.660 48.250 21.486 1.00 17.41 C +ATOM 175 N GLN A 25 4.623 47.639 22.805 1.00 17.44 N +ATOM 176 CA GLN A 25 3.743 48.001 23.972 1.00 18.87 C +ATOM 177 C GLN A 25 2.476 48.811 23.642 1.00 18.88 C +ATOM 178 O GLN A 25 1.787 49.325 24.541 1.00 19.08 O +ATOM 179 CB GLN A 25 4.570 48.733 25.062 1.00 18.70 C +ATOM 180 CG GLN A 25 5.715 47.839 25.644 1.00 19.85 C +ATOM 181 CD GLN A 25 5.192 46.588 26.346 1.00 22.15 C +ATOM 182 OE1 GLN A 25 4.040 46.540 26.806 1.00 25.01 O +ATOM 183 NE2 GLN A 25 6.035 45.573 26.446 1.00 22.42 N +ATOM 184 N SER A 26 2.145 48.938 22.364 1.00 19.33 N +ATOM 185 CA SER A 26 0.912 49.648 21.988 1.00 19.59 C +ATOM 186 C SER A 26 -0.320 48.844 22.464 1.00 20.50 C +ATOM 187 O SER A 26 -0.237 47.623 22.727 1.00 20.29 O +ATOM 188 CB SER A 26 0.884 49.925 20.458 1.00 19.67 C +ATOM 189 OG SER A 26 1.003 48.706 19.704 1.00 19.08 O +ATOM 190 N GLU A 27 -1.464 49.514 22.603 1.00 20.38 N +ATOM 191 CA GLU A 27 -2.696 48.815 22.968 1.00 21.73 C +ATOM 192 C GLU A 27 -2.899 47.630 22.013 1.00 21.32 C +ATOM 193 O GLU A 27 -2.468 47.677 20.875 1.00 21.54 O +ATOM 194 CB GLU A 27 -3.896 49.808 23.027 1.00 21.74 C +ATOM 195 CG GLU A 27 -3.758 50.649 24.300 1.00 23.24 C +ATOM 196 CD GLU A 27 -4.826 51.710 24.535 1.00 25.87 C +ATOM 197 OE1 GLU A 27 -5.477 52.149 23.596 1.00 25.51 O +ATOM 198 OE2 GLU A 27 -5.000 52.130 25.698 1.00 25.72 O +ATOM 199 N PRO A 28 -3.555 46.560 22.480 1.00 21.62 N +ATOM 200 CA PRO A 28 -3.561 45.259 21.771 1.00 21.72 C +ATOM 201 C PRO A 28 -4.457 45.171 20.496 1.00 22.43 C +ATOM 202 O PRO A 28 -5.421 44.391 20.437 1.00 22.00 O +ATOM 203 CB PRO A 28 -4.038 44.271 22.855 1.00 21.26 C +ATOM 204 CG PRO A 28 -4.768 45.110 23.839 1.00 21.70 C +ATOM 205 CD PRO A 28 -4.153 46.479 23.829 1.00 21.25 C +ATOM 206 N VAL A 29 -4.098 45.952 19.485 1.00 23.11 N +ATOM 207 CA VAL A 29 -4.811 46.024 18.207 1.00 23.26 C +ATOM 208 C VAL A 29 -3.804 45.704 17.111 1.00 23.88 C +ATOM 209 O VAL A 29 -2.754 46.345 17.004 1.00 23.18 O +ATOM 210 CB VAL A 29 -5.430 47.448 17.974 1.00 23.27 C +ATOM 211 CG1 VAL A 29 -6.368 47.470 16.769 1.00 21.69 C +ATOM 212 CG2 VAL A 29 -6.114 47.970 19.256 1.00 22.25 C +ATOM 213 N LYS A 30 -4.115 44.681 16.315 1.00 24.89 N +ATOM 214 CA LYS A 30 -3.209 44.200 15.259 1.00 26.06 C +ATOM 215 C LYS A 30 -3.450 44.954 13.937 1.00 26.00 C +ATOM 216 O LYS A 30 -4.425 44.686 13.244 1.00 26.59 O +ATOM 217 CB LYS A 30 -3.467 42.692 15.077 1.00 26.61 C +ATOM 218 CG LYS A 30 -2.248 41.822 14.884 1.00 28.45 C +ATOM 219 CD LYS A 30 -1.999 41.562 13.421 1.00 28.74 C +ATOM 220 CE LYS A 30 -0.999 40.442 13.240 1.00 30.16 C +ATOM 221 NZ LYS A 30 -0.274 40.696 11.977 1.00 28.79 N +ATOM 222 N TYR A 31 -2.613 45.936 13.595 1.00 25.80 N +ATOM 223 CA TYR A 31 -2.729 46.580 12.294 1.00 25.22 C +ATOM 224 C TYR A 31 -1.864 45.867 11.261 1.00 27.00 C +ATOM 225 O TYR A 31 -0.798 45.336 11.598 1.00 26.61 O +ATOM 226 CB TYR A 31 -2.308 48.046 12.361 1.00 25.12 C +ATOM 227 CG TYR A 31 -3.212 48.892 13.226 1.00 23.08 C +ATOM 228 CD1 TYR A 31 -4.287 49.571 12.673 1.00 19.20 C +ATOM 229 CD2 TYR A 31 -3.015 48.958 14.603 1.00 18.39 C +ATOM 230 CE1 TYR A 31 -5.114 50.341 13.448 1.00 19.06 C +ATOM 231 CE2 TYR A 31 -3.845 49.730 15.405 1.00 20.45 C +ATOM 232 CZ TYR A 31 -4.898 50.419 14.815 1.00 18.45 C +ATOM 233 OH TYR A 31 -5.738 51.188 15.591 1.00 21.38 O +ATOM 234 N GLU A 32 -2.333 45.871 10.016 1.00 27.55 N +ATOM 235 CA GLU A 32 -1.576 45.372 8.868 1.00 30.56 C +ATOM 236 C GLU A 32 -1.594 46.427 7.779 1.00 30.42 C +ATOM 237 O GLU A 32 -2.638 46.991 7.484 1.00 30.34 O +ATOM 238 CB GLU A 32 -2.173 44.050 8.322 1.00 31.34 C +ATOM 239 CG GLU A 32 -2.005 42.866 9.281 1.00 36.06 C +ATOM 240 CD GLU A 32 -2.344 41.526 8.649 1.00 43.47 C +ATOM 241 OE1 GLU A 32 -2.926 41.513 7.531 1.00 44.52 O +ATOM 242 OE2 GLU A 32 -2.042 40.483 9.294 1.00 47.61 O +ATOM 243 N ALA A 33 -0.434 46.703 7.200 1.00 31.88 N +ATOM 244 CA ALA A 33 -0.345 47.623 6.073 1.00 33.76 C +ATOM 245 C ALA A 33 -1.055 47.022 4.860 1.00 35.50 C +ATOM 246 O ALA A 33 -0.894 45.835 4.550 1.00 36.09 O +ATOM 247 CB ALA A 33 1.091 47.937 5.747 1.00 33.39 C +ATOM 248 N ASP A 34 -1.890 47.820 4.207 1.00 36.96 N +ATOM 249 CA ASP A 34 -2.438 47.426 2.914 1.00 38.49 C +ATOM 250 C ASP A 34 -1.577 48.087 1.835 1.00 39.63 C +ATOM 251 O ASP A 34 -1.554 49.309 1.686 1.00 38.98 O +ATOM 252 CB ASP A 34 -3.896 47.845 2.800 1.00 38.53 C +ATOM 253 CG ASP A 34 -4.540 47.355 1.528 1.00 39.38 C +ATOM 254 OD1 ASP A 34 -4.180 47.841 0.442 1.00 37.36 O +ATOM 255 OD2 ASP A 34 -5.405 46.469 1.619 1.00 42.57 O +ATOM 256 N LYS A 35 -0.810 47.282 1.120 1.00 41.54 N +ATOM 257 CA LYS A 35 0.108 47.856 0.134 1.00 44.05 C +ATOM 258 C LYS A 35 -0.633 48.369 -1.124 1.00 44.94 C +ATOM 259 O LYS A 35 -0.100 49.187 -1.886 1.00 45.87 O +ATOM 260 CB LYS A 35 1.242 46.868 -0.197 1.00 44.78 C +ATOM 261 CG LYS A 35 2.517 47.072 0.672 1.00 44.98 C +ATOM 262 CD LYS A 35 2.936 45.792 1.403 1.00 45.99 C +ATOM 263 CE LYS A 35 1.747 45.213 2.158 1.00 47.71 C +ATOM 264 NZ LYS A 35 2.070 44.230 3.257 1.00 48.24 N +ATOM 265 N ALA A 36 -1.873 47.914 -1.313 1.00 44.65 N +ATOM 266 CA ALA A 36 -2.707 48.405 -2.391 1.00 44.81 C +ATOM 267 C ALA A 36 -3.519 49.652 -2.006 1.00 44.91 C +ATOM 268 O ALA A 36 -4.046 50.317 -2.886 1.00 45.28 O +ATOM 269 CB ALA A 36 -3.656 47.309 -2.864 1.00 44.78 C +ATOM 270 N LEU A 37 -3.680 49.937 -0.708 1.00 43.77 N +ATOM 271 CA LEU A 37 -4.397 51.142 -0.298 1.00 42.57 C +ATOM 272 C LEU A 37 -3.404 52.197 0.145 1.00 41.06 C +ATOM 273 O LEU A 37 -3.735 53.383 0.193 1.00 41.20 O +ATOM 274 CB LEU A 37 -5.379 50.861 0.844 1.00 42.92 C +ATOM 275 CG LEU A 37 -6.450 49.797 0.612 1.00 43.81 C +ATOM 276 CD1 LEU A 37 -7.367 49.636 1.818 1.00 44.72 C +ATOM 277 CD2 LEU A 37 -7.258 50.154 -0.608 1.00 45.97 C +ATOM 278 N GLY A 38 -2.183 51.759 0.469 1.00 39.85 N +ATOM 279 CA GLY A 38 -1.176 52.617 1.131 1.00 37.63 C +ATOM 280 C GLY A 38 -1.501 53.016 2.583 1.00 36.28 C +ATOM 281 O GLY A 38 -1.003 54.034 3.081 1.00 36.55 O +ATOM 282 N LEU A 39 -2.339 52.234 3.265 1.00 33.68 N +ATOM 283 CA LEU A 39 -2.850 52.621 4.595 1.00 31.37 C +ATOM 284 C LEU A 39 -2.765 51.448 5.548 1.00 29.37 C +ATOM 285 O LEU A 39 -2.761 50.301 5.099 1.00 28.58 O +ATOM 286 CB LEU A 39 -4.311 53.094 4.516 1.00 30.92 C +ATOM 287 CG LEU A 39 -4.593 54.380 3.727 1.00 31.84 C +ATOM 288 CD1 LEU A 39 -6.088 54.592 3.563 1.00 31.37 C +ATOM 289 CD2 LEU A 39 -3.950 55.577 4.413 1.00 30.83 C +ATOM 290 N LEU A 40 -2.685 51.738 6.854 1.00 27.18 N +ATOM 291 CA LEU A 40 -2.802 50.690 7.873 1.00 26.07 C +ATOM 292 C LEU A 40 -4.260 50.295 8.039 1.00 24.63 C +ATOM 293 O LEU A 40 -5.140 51.150 8.125 1.00 23.26 O +ATOM 294 CB LEU A 40 -2.218 51.115 9.238 1.00 25.71 C +ATOM 295 CG LEU A 40 -0.687 51.351 9.263 1.00 25.93 C +ATOM 296 CD1 LEU A 40 -0.250 52.020 10.547 1.00 24.92 C +ATOM 297 CD2 LEU A 40 0.064 50.039 9.032 1.00 24.73 C +ATOM 298 N VAL A 41 -4.486 48.988 8.093 1.00 24.43 N +ATOM 299 CA VAL A 41 -5.822 48.433 8.262 1.00 25.12 C +ATOM 300 C VAL A 41 -5.926 47.622 9.556 1.00 25.36 C +ATOM 301 O VAL A 41 -4.999 46.846 9.885 1.00 24.93 O +ATOM 302 CB VAL A 41 -6.155 47.533 7.039 1.00 25.41 C +ATOM 303 CG1 VAL A 41 -7.438 46.711 7.244 1.00 26.79 C +ATOM 304 CG2 VAL A 41 -6.270 48.406 5.797 1.00 24.02 C +ATOM 305 N VAL A 42 -7.038 47.774 10.285 1.00 24.79 N +ATOM 306 CA VAL A 42 -7.232 46.981 11.515 1.00 25.06 C +ATOM 307 C VAL A 42 -7.535 45.513 11.174 1.00 25.94 C +ATOM 308 O VAL A 42 -8.638 45.197 10.731 1.00 26.93 O +ATOM 309 CB VAL A 42 -8.420 47.451 12.370 1.00 24.99 C +ATOM 310 CG1 VAL A 42 -8.436 46.718 13.688 1.00 24.48 C +ATOM 311 CG2 VAL A 42 -8.400 48.939 12.607 1.00 24.84 C +ATOM 312 N ASP A 43 -6.578 44.619 11.376 1.00 25.33 N +ATOM 313 CA ASP A 43 -6.825 43.221 11.140 1.00 26.20 C +ATOM 314 C ASP A 43 -7.737 42.626 12.210 1.00 25.70 C +ATOM 315 O ASP A 43 -8.787 42.081 11.879 1.00 25.64 O +ATOM 316 CB ASP A 43 -5.524 42.401 11.040 1.00 27.86 C +ATOM 317 CG ASP A 43 -5.814 40.952 10.725 1.00 30.64 C +ATOM 318 OD1 ASP A 43 -6.372 40.686 9.642 1.00 37.20 O +ATOM 319 OD2 ASP A 43 -5.576 40.084 11.564 1.00 33.64 O +ATOM 320 N ARG A 44 -7.345 42.729 13.482 1.00 23.76 N +ATOM 321 CA ARG A 44 -8.190 42.297 14.561 1.00 24.05 C +ATOM 322 C ARG A 44 -7.761 42.917 15.906 1.00 24.08 C +ATOM 323 O ARG A 44 -6.608 43.338 16.065 1.00 24.67 O +ATOM 324 CB ARG A 44 -8.171 40.764 14.678 1.00 24.30 C +ATOM 325 CG ARG A 44 -6.835 40.203 15.246 1.00 24.56 C +ATOM 326 CD ARG A 44 -6.770 38.712 15.056 1.00 28.25 C +ATOM 327 NE ARG A 44 -5.527 38.105 15.527 1.00 30.15 N +ATOM 328 CZ ARG A 44 -4.436 37.938 14.774 1.00 30.95 C +ATOM 329 NH1 ARG A 44 -4.413 38.364 13.500 1.00 29.56 N +ATOM 330 NH2 ARG A 44 -3.363 37.358 15.299 1.00 27.85 N +ATOM 331 N PHE A 45 -8.708 42.999 16.839 1.00 23.14 N +ATOM 332 CA PHE A 45 -8.408 43.175 18.265 1.00 23.01 C +ATOM 333 C PHE A 45 -7.891 41.854 18.809 1.00 23.22 C +ATOM 334 O PHE A 45 -8.571 40.821 18.730 1.00 22.43 O +ATOM 335 CB PHE A 45 -9.621 43.696 19.024 1.00 23.17 C +ATOM 336 CG PHE A 45 -9.904 45.174 18.756 1.00 23.12 C +ATOM 337 CD1 PHE A 45 -9.587 46.141 19.696 1.00 22.31 C +ATOM 338 CD2 PHE A 45 -10.456 45.591 17.546 1.00 22.00 C +ATOM 339 CE1 PHE A 45 -9.815 47.525 19.445 1.00 19.37 C +ATOM 340 CE2 PHE A 45 -10.689 46.946 17.299 1.00 24.14 C +ATOM 341 CZ PHE A 45 -10.363 47.920 18.257 1.00 20.26 C +ATOM 342 N ILE A 46 -6.653 41.870 19.303 1.00 22.58 N +ATOM 343 CA ILE A 46 -6.049 40.660 19.811 1.00 22.68 C +ATOM 344 C ILE A 46 -6.900 40.042 20.937 1.00 22.39 C +ATOM 345 O ILE A 46 -7.174 40.697 21.955 1.00 22.85 O +ATOM 346 CB ILE A 46 -4.573 40.901 20.294 1.00 22.60 C +ATOM 347 CG1 ILE A 46 -3.715 41.434 19.130 1.00 21.33 C +ATOM 348 CG2 ILE A 46 -4.021 39.618 20.954 1.00 19.70 C +ATOM 349 CD1 ILE A 46 -2.327 41.989 19.546 1.00 21.68 C +ATOM 350 N GLY A 47 -7.299 38.783 20.761 1.00 21.82 N +ATOM 351 CA GLY A 47 -8.248 38.135 21.701 1.00 20.72 C +ATOM 352 C GLY A 47 -7.794 38.069 23.156 1.00 20.43 C +ATOM 353 O GLY A 47 -8.593 38.229 24.093 1.00 19.67 O +ATOM 354 N THR A 48 -6.499 37.840 23.355 1.00 19.77 N +ATOM 355 CA THR A 48 -5.932 37.739 24.683 1.00 19.66 C +ATOM 356 C THR A 48 -5.613 39.106 25.314 1.00 20.30 C +ATOM 357 O THR A 48 -5.329 39.200 26.512 1.00 20.72 O +ATOM 358 CB THR A 48 -4.619 36.917 24.634 1.00 20.30 C +ATOM 359 OG1 THR A 48 -3.768 37.491 23.644 1.00 20.44 O +ATOM 360 CG2 THR A 48 -4.860 35.453 24.277 1.00 17.40 C +ATOM 361 N GLY A 49 -5.651 40.181 24.535 1.00 20.99 N +ATOM 362 CA GLY A 49 -5.269 41.493 25.078 1.00 20.69 C +ATOM 363 C GLY A 49 -3.758 41.638 25.240 1.00 20.94 C +ATOM 364 O GLY A 49 -3.299 42.624 25.806 1.00 21.56 O +ATOM 365 N MET A 50 -2.983 40.667 24.749 1.00 19.51 N +ATOM 366 CA MET A 50 -1.499 40.721 24.822 1.00 18.69 C +ATOM 367 C MET A 50 -0.883 41.715 23.837 1.00 18.94 C +ATOM 368 O MET A 50 -1.429 41.916 22.738 1.00 19.06 O +ATOM 369 CB MET A 50 -0.898 39.311 24.595 1.00 18.46 C +ATOM 370 CG MET A 50 -1.205 38.359 25.743 1.00 16.28 C +ATOM 371 SD MET A 50 -0.534 36.732 25.499 1.00 20.35 S +ATOM 372 CE MET A 50 1.161 36.996 26.020 1.00 15.70 C +ATOM 373 N ARG A 51 0.266 42.306 24.221 1.00 18.83 N +ATOM 374 CA ARG A 51 0.901 43.405 23.476 1.00 18.83 C +ATOM 375 C ARG A 51 2.255 42.953 22.927 1.00 19.23 C +ATOM 376 O ARG A 51 3.000 42.203 23.600 1.00 18.63 O +ATOM 377 CB ARG A 51 1.111 44.671 24.362 1.00 18.43 C +ATOM 378 CG ARG A 51 -0.162 45.289 24.984 1.00 17.94 C +ATOM 379 CD ARG A 51 0.141 46.584 25.739 1.00 17.07 C +ATOM 380 NE ARG A 51 -1.057 47.096 26.434 1.00 17.53 N +ATOM 381 CZ ARG A 51 -1.381 48.382 26.591 1.00 17.75 C +ATOM 382 NH1 ARG A 51 -0.616 49.350 26.093 1.00 15.93 N +ATOM 383 NH2 ARG A 51 -2.498 48.705 27.248 1.00 17.88 N +ATOM 384 N TYR A 52 2.587 43.425 21.724 1.00 18.81 N +ATOM 385 CA TYR A 52 3.925 43.167 21.179 1.00 20.17 C +ATOM 386 C TYR A 52 4.969 43.754 22.104 1.00 19.88 C +ATOM 387 O TYR A 52 4.909 44.924 22.419 1.00 19.46 O +ATOM 388 CB TYR A 52 4.063 43.715 19.744 1.00 19.61 C +ATOM 389 CG TYR A 52 3.327 42.878 18.720 1.00 21.97 C +ATOM 390 CD1 TYR A 52 4.031 42.070 17.818 1.00 22.85 C +ATOM 391 CD2 TYR A 52 1.918 42.863 18.667 1.00 21.92 C +ATOM 392 CE1 TYR A 52 3.370 41.301 16.883 1.00 21.48 C +ATOM 393 CE2 TYR A 52 1.241 42.079 17.734 1.00 22.65 C +ATOM 394 CZ TYR A 52 1.964 41.293 16.853 1.00 23.39 C +ATOM 395 OH TYR A 52 1.315 40.519 15.914 1.00 21.36 O +ATOM 396 N PRO A 53 5.919 42.920 22.572 1.00 21.29 N +ATOM 397 CA PRO A 53 7.017 43.398 23.428 1.00 21.87 C +ATOM 398 C PRO A 53 8.071 44.269 22.717 1.00 21.70 C +ATOM 399 O PRO A 53 8.819 44.986 23.394 1.00 21.93 O +ATOM 400 CB PRO A 53 7.642 42.106 23.998 1.00 21.72 C +ATOM 401 CG PRO A 53 7.174 40.998 23.100 1.00 22.80 C +ATOM 402 CD PRO A 53 5.885 41.443 22.446 1.00 22.07 C +ATOM 403 N VAL A 54 8.100 44.236 21.382 1.00 20.85 N +ATOM 404 CA VAL A 54 9.007 45.057 20.582 1.00 21.55 C +ATOM 405 C VAL A 54 8.232 45.490 19.356 1.00 20.83 C +ATOM 406 O VAL A 54 7.140 44.972 19.117 1.00 20.05 O +ATOM 407 CB VAL A 54 10.281 44.275 20.107 1.00 22.98 C +ATOM 408 CG1 VAL A 54 11.079 43.719 21.297 1.00 23.11 C +ATOM 409 CG2 VAL A 54 9.884 43.163 19.151 1.00 24.55 C +ATOM 410 N ASN A 55 8.770 46.452 18.602 1.00 19.90 N +ATOM 411 CA ASN A 55 8.127 46.907 17.367 1.00 21.21 C +ATOM 412 C ASN A 55 7.999 45.819 16.329 1.00 20.69 C +ATOM 413 O ASN A 55 8.869 44.984 16.187 1.00 21.68 O +ATOM 414 CB ASN A 55 8.838 48.129 16.748 1.00 20.69 C +ATOM 415 CG ASN A 55 9.109 49.224 17.771 1.00 20.45 C +ATOM 416 OD1 ASN A 55 8.221 50.008 18.123 1.00 17.26 O +ATOM 417 ND2 ASN A 55 10.351 49.292 18.238 1.00 18.77 N +ATOM 418 N TYR A 56 6.903 45.849 15.596 1.00 20.79 N +ATOM 419 CA TYR A 56 6.622 44.831 14.583 1.00 20.61 C +ATOM 420 C TYR A 56 6.243 45.465 13.238 1.00 20.45 C +ATOM 421 O TYR A 56 5.457 46.410 13.177 1.00 19.77 O +ATOM 422 CB TYR A 56 5.479 43.957 15.068 1.00 20.53 C +ATOM 423 CG TYR A 56 5.162 42.754 14.189 1.00 22.99 C +ATOM 424 CD1 TYR A 56 6.112 41.762 13.982 1.00 23.35 C +ATOM 425 CD2 TYR A 56 3.898 42.608 13.593 1.00 22.26 C +ATOM 426 CE1 TYR A 56 5.834 40.653 13.201 1.00 24.86 C +ATOM 427 CE2 TYR A 56 3.606 41.493 12.825 1.00 25.04 C +ATOM 428 CZ TYR A 56 4.585 40.513 12.637 1.00 26.22 C +ATOM 429 OH TYR A 56 4.338 39.402 11.853 1.00 26.67 O +ATOM 430 N GLY A 57 6.814 44.934 12.167 1.00 20.57 N +ATOM 431 CA GLY A 57 6.543 45.425 10.820 1.00 20.64 C +ATOM 432 C GLY A 57 7.020 44.440 9.773 1.00 20.42 C +ATOM 433 O GLY A 57 7.108 43.230 10.030 1.00 20.25 O +ATOM 434 N PHE A 58 7.317 44.956 8.590 1.00 21.49 N +ATOM 435 CA PHE A 58 7.723 44.098 7.462 1.00 22.42 C +ATOM 436 C PHE A 58 8.739 44.803 6.557 1.00 21.95 C +ATOM 437 O PHE A 58 8.846 46.035 6.548 1.00 21.27 O +ATOM 438 CB PHE A 58 6.473 43.668 6.628 1.00 22.41 C +ATOM 439 CG PHE A 58 5.792 44.818 5.923 1.00 25.13 C +ATOM 440 CD1 PHE A 58 6.084 45.105 4.587 1.00 25.77 C +ATOM 441 CD2 PHE A 58 4.881 45.626 6.598 1.00 22.93 C +ATOM 442 CE1 PHE A 58 5.476 46.166 3.936 1.00 24.40 C +ATOM 443 CE2 PHE A 58 4.289 46.717 5.972 1.00 23.86 C +ATOM 444 CZ PHE A 58 4.575 46.987 4.632 1.00 26.77 C +ATOM 445 N ILE A 59 9.456 44.013 5.766 1.00 22.61 N +ATOM 446 CA ILE A 59 10.300 44.571 4.683 1.00 23.33 C +ATOM 447 C ILE A 59 9.523 44.749 3.371 1.00 23.32 C +ATOM 448 O ILE A 59 9.003 43.779 2.827 1.00 24.29 O +ATOM 449 CB ILE A 59 11.557 43.690 4.429 1.00 22.84 C +ATOM 450 CG1 ILE A 59 12.281 43.398 5.748 1.00 22.43 C +ATOM 451 CG2 ILE A 59 12.476 44.360 3.354 1.00 22.00 C +ATOM 452 CD1 ILE A 59 13.474 42.443 5.622 1.00 19.09 C +ATOM 453 N PRO A 60 9.420 45.985 2.872 1.00 24.84 N +ATOM 454 CA PRO A 60 8.675 46.182 1.622 1.00 26.36 C +ATOM 455 C PRO A 60 9.384 45.522 0.421 1.00 27.39 C +ATOM 456 O PRO A 60 10.605 45.317 0.441 1.00 27.93 O +ATOM 457 CB PRO A 60 8.639 47.712 1.456 1.00 25.61 C +ATOM 458 CG PRO A 60 9.839 48.222 2.254 1.00 25.88 C +ATOM 459 CD PRO A 60 9.955 47.257 3.418 1.00 25.38 C +ATOM 460 N GLN A 61 8.609 45.181 -0.600 1.00 28.29 N +ATOM 461 CA GLN A 61 9.159 44.570 -1.809 1.00 29.22 C +ATOM 462 C GLN A 61 9.810 43.208 -1.540 1.00 29.01 C +ATOM 463 O GLN A 61 10.828 42.854 -2.136 1.00 28.95 O +ATOM 464 CB GLN A 61 10.069 45.568 -2.526 1.00 29.21 C +ATOM 465 CG GLN A 61 9.202 46.671 -3.102 1.00 34.78 C +ATOM 466 CD GLN A 61 9.957 47.810 -3.699 1.00 43.57 C +ATOM 467 OE1 GLN A 61 9.386 48.866 -3.940 1.00 47.87 O +ATOM 468 NE2 GLN A 61 11.245 47.619 -3.948 1.00 46.49 N +ATOM 469 N THR A 62 9.218 42.458 -0.616 1.00 28.00 N +ATOM 470 CA THR A 62 9.631 41.093 -0.365 1.00 28.25 C +ATOM 471 C THR A 62 8.383 40.230 -0.370 1.00 29.87 C +ATOM 472 O THR A 62 7.269 40.730 -0.203 1.00 29.15 O +ATOM 473 CB THR A 62 10.397 40.905 0.989 1.00 28.15 C +ATOM 474 OG1 THR A 62 9.545 41.234 2.104 1.00 27.37 O +ATOM 475 CG2 THR A 62 11.679 41.753 1.027 1.00 26.31 C +ATOM 476 N LEU A 63 8.566 38.932 -0.548 1.00 31.16 N +ATOM 477 CA LEU A 63 7.455 38.007 -0.575 1.00 33.88 C +ATOM 478 C LEU A 63 7.944 36.718 0.039 1.00 35.46 C +ATOM 479 O LEU A 63 8.786 36.019 -0.523 1.00 35.30 O +ATOM 480 CB LEU A 63 6.945 37.808 -2.016 1.00 33.87 C +ATOM 481 CG LEU A 63 5.795 36.841 -2.280 1.00 34.60 C +ATOM 482 CD1 LEU A 63 4.662 37.180 -1.363 1.00 36.93 C +ATOM 483 CD2 LEU A 63 5.340 36.969 -3.724 1.00 36.15 C +ATOM 484 N SER A 64 7.437 36.436 1.230 1.00 38.38 N +ATOM 485 CA SER A 64 7.886 35.307 2.023 1.00 41.11 C +ATOM 486 C SER A 64 7.191 34.036 1.577 1.00 43.10 C +ATOM 487 O SER A 64 6.349 34.064 0.671 1.00 42.92 O +ATOM 488 CB SER A 64 7.564 35.543 3.500 1.00 41.35 C +ATOM 489 OG SER A 64 8.363 34.696 4.315 1.00 42.71 O +ATOM 490 N GLY A 65 7.537 32.927 2.229 1.00 45.14 N +ATOM 491 CA GLY A 65 6.892 31.638 1.968 1.00 47.76 C +ATOM 492 C GLY A 65 5.362 31.636 2.005 1.00 49.24 C +ATOM 493 O GLY A 65 4.723 30.859 1.293 1.00 50.21 O +ATOM 494 N ASP A 66 4.753 32.482 2.832 1.00 50.27 N +ATOM 495 CA ASP A 66 3.284 32.510 2.911 1.00 50.78 C +ATOM 496 C ASP A 66 2.609 33.496 1.940 1.00 50.21 C +ATOM 497 O ASP A 66 1.385 33.600 1.897 1.00 50.77 O +ATOM 498 CB ASP A 66 2.820 32.798 4.342 1.00 51.29 C +ATOM 499 CG ASP A 66 3.509 34.005 4.947 1.00 54.17 C +ATOM 500 OD1 ASP A 66 3.722 35.014 4.219 1.00 55.27 O +ATOM 501 OD2 ASP A 66 3.843 33.936 6.161 1.00 57.76 O +ATOM 502 N GLY A 67 3.379 34.233 1.160 1.00 48.96 N +ATOM 503 CA GLY A 67 2.739 35.181 0.272 1.00 47.16 C +ATOM 504 C GLY A 67 2.604 36.550 0.903 1.00 45.61 C +ATOM 505 O GLY A 67 2.093 37.467 0.266 1.00 46.42 O +ATOM 506 N ASP A 68 3.068 36.690 2.147 1.00 44.01 N +ATOM 507 CA ASP A 68 3.176 37.990 2.828 1.00 41.68 C +ATOM 508 C ASP A 68 4.634 38.442 2.804 1.00 38.69 C +ATOM 509 O ASP A 68 5.530 37.609 2.702 1.00 38.18 O +ATOM 510 CB ASP A 68 2.772 37.862 4.299 1.00 43.06 C +ATOM 511 CG ASP A 68 1.260 37.693 4.501 1.00 47.11 C +ATOM 512 OD1 ASP A 68 0.458 38.106 3.618 1.00 50.50 O +ATOM 513 OD2 ASP A 68 0.885 37.144 5.569 1.00 51.66 O +ATOM 514 N PRO A 69 4.880 39.755 2.945 1.00 35.51 N +ATOM 515 CA PRO A 69 6.253 40.252 3.039 1.00 33.20 C +ATOM 516 C PRO A 69 7.007 39.648 4.217 1.00 31.00 C +ATOM 517 O PRO A 69 6.388 39.081 5.103 1.00 30.18 O +ATOM 518 CB PRO A 69 6.082 41.767 3.260 1.00 33.04 C +ATOM 519 CG PRO A 69 4.739 42.103 2.734 1.00 35.64 C +ATOM 520 CD PRO A 69 3.880 40.839 2.971 1.00 35.76 C +ATOM 521 N VAL A 70 8.336 39.778 4.232 1.00 29.44 N +ATOM 522 CA VAL A 70 9.151 39.250 5.348 1.00 27.95 C +ATOM 523 C VAL A 70 8.837 40.047 6.625 1.00 26.77 C +ATOM 524 O VAL A 70 8.915 41.270 6.619 1.00 26.46 O +ATOM 525 CB VAL A 70 10.703 39.275 5.026 1.00 27.88 C +ATOM 526 CG1 VAL A 70 11.514 38.958 6.258 1.00 27.39 C +ATOM 527 CG2 VAL A 70 11.056 38.280 3.898 1.00 27.44 C +ATOM 528 N ASP A 71 8.452 39.351 7.693 1.00 26.51 N +ATOM 529 CA ASP A 71 8.153 39.968 9.014 1.00 26.25 C +ATOM 530 C ASP A 71 9.381 40.260 9.866 1.00 25.56 C +ATOM 531 O ASP A 71 10.322 39.450 9.926 1.00 25.69 O +ATOM 532 CB ASP A 71 7.284 39.034 9.838 1.00 26.37 C +ATOM 533 CG ASP A 71 5.942 38.790 9.227 1.00 28.24 C +ATOM 534 OD1 ASP A 71 5.331 39.745 8.677 1.00 30.97 O +ATOM 535 OD2 ASP A 71 5.496 37.624 9.306 1.00 28.38 O +ATOM 536 N VAL A 72 9.362 41.410 10.542 1.00 24.69 N +ATOM 537 CA VAL A 72 10.480 41.870 11.382 1.00 22.19 C +ATOM 538 C VAL A 72 10.034 42.475 12.735 1.00 22.12 C +ATOM 539 O VAL A 72 9.148 43.330 12.811 1.00 21.39 O +ATOM 540 CB VAL A 72 11.395 42.879 10.629 1.00 22.97 C +ATOM 541 CG1 VAL A 72 12.704 43.137 11.390 1.00 20.10 C +ATOM 542 CG2 VAL A 72 11.667 42.402 9.171 1.00 21.68 C +ATOM 543 N LEU A 73 10.666 41.984 13.798 1.00 21.86 N +ATOM 544 CA LEU A 73 10.673 42.593 15.127 1.00 21.24 C +ATOM 545 C LEU A 73 11.900 43.511 15.274 1.00 21.59 C +ATOM 546 O LEU A 73 13.030 43.037 15.180 1.00 22.50 O +ATOM 547 CB LEU A 73 10.739 41.468 16.172 1.00 21.37 C +ATOM 548 CG LEU A 73 9.561 40.490 16.014 1.00 21.82 C +ATOM 549 CD1 LEU A 73 9.902 39.045 16.446 1.00 23.52 C +ATOM 550 CD2 LEU A 73 8.331 41.011 16.770 1.00 20.84 C +ATOM 551 N VAL A 74 11.681 44.815 15.494 1.00 20.95 N +ATOM 552 CA VAL A 74 12.752 45.796 15.684 1.00 19.54 C +ATOM 553 C VAL A 74 12.771 46.277 17.140 1.00 20.67 C +ATOM 554 O VAL A 74 11.768 46.843 17.646 1.00 19.81 O +ATOM 555 CB VAL A 74 12.558 47.027 14.796 1.00 19.11 C +ATOM 556 CG1 VAL A 74 13.790 47.916 14.808 1.00 16.39 C +ATOM 557 CG2 VAL A 74 12.228 46.592 13.359 1.00 19.06 C +ATOM 558 N ILE A 75 13.897 46.030 17.812 1.00 20.76 N +ATOM 559 CA ILE A 75 14.131 46.466 19.213 1.00 21.77 C +ATOM 560 C ILE A 75 14.639 47.928 19.210 1.00 22.17 C +ATOM 561 O ILE A 75 15.604 48.245 18.487 1.00 22.78 O +ATOM 562 CB ILE A 75 15.171 45.535 19.898 1.00 21.89 C +ATOM 563 CG1 ILE A 75 14.703 44.087 19.786 1.00 21.31 C +ATOM 564 CG2 ILE A 75 15.461 45.946 21.348 1.00 21.98 C +ATOM 565 CD1 ILE A 75 15.763 43.077 20.206 1.00 21.97 C +ATOM 566 N THR A 76 13.967 48.806 19.964 1.00 21.05 N +ATOM 567 CA THR A 76 14.385 50.220 20.093 1.00 20.95 C +ATOM 568 C THR A 76 14.241 50.718 21.543 1.00 20.55 C +ATOM 569 O THR A 76 13.450 50.161 22.299 1.00 19.88 O +ATOM 570 CB THR A 76 13.551 51.151 19.153 1.00 20.86 C +ATOM 571 OG1 THR A 76 12.167 51.040 19.496 1.00 19.99 O +ATOM 572 CG2 THR A 76 13.745 50.762 17.658 1.00 18.48 C +ATOM 573 N PRO A 77 14.992 51.770 21.934 1.00 20.91 N +ATOM 574 CA PRO A 77 14.763 52.260 23.309 1.00 21.70 C +ATOM 575 C PRO A 77 13.382 52.961 23.583 1.00 21.66 C +ATOM 576 O PRO A 77 12.953 53.016 24.743 1.00 21.57 O +ATOM 577 CB PRO A 77 15.953 53.209 23.563 1.00 21.31 C +ATOM 578 CG PRO A 77 16.481 53.561 22.213 1.00 21.76 C +ATOM 579 CD PRO A 77 16.165 52.408 21.295 1.00 20.66 C +ATOM 580 N PHE A 78 12.709 53.456 22.545 1.00 20.64 N +ATOM 581 CA PHE A 78 11.360 54.051 22.662 1.00 21.02 C +ATOM 582 C PHE A 78 10.529 53.502 21.508 1.00 20.26 C +ATOM 583 O PHE A 78 11.074 53.303 20.404 1.00 20.09 O +ATOM 584 CB PHE A 78 11.409 55.603 22.539 1.00 20.99 C +ATOM 585 CG PHE A 78 12.129 56.296 23.695 1.00 22.97 C +ATOM 586 CD1 PHE A 78 11.482 56.496 24.931 1.00 22.93 C +ATOM 587 CD2 PHE A 78 13.446 56.731 23.549 1.00 20.66 C +ATOM 588 CE1 PHE A 78 12.148 57.089 25.992 1.00 23.48 C +ATOM 589 CE2 PHE A 78 14.113 57.329 24.597 1.00 21.65 C +ATOM 590 CZ PHE A 78 13.472 57.507 25.823 1.00 23.50 C +ATOM 591 N PRO A 79 9.201 53.295 21.718 1.00 20.67 N +ATOM 592 CA PRO A 79 8.431 52.730 20.586 1.00 19.72 C +ATOM 593 C PRO A 79 8.502 53.606 19.329 1.00 19.61 C +ATOM 594 O PRO A 79 8.687 54.817 19.437 1.00 18.61 O +ATOM 595 CB PRO A 79 6.993 52.618 21.137 1.00 20.21 C +ATOM 596 CG PRO A 79 7.184 52.577 22.674 1.00 21.91 C +ATOM 597 CD PRO A 79 8.355 53.522 22.918 1.00 19.80 C +ATOM 598 N LEU A 80 8.406 52.986 18.147 1.00 19.41 N +ATOM 599 CA LEU A 80 8.376 53.710 16.869 1.00 19.62 C +ATOM 600 C LEU A 80 6.920 53.965 16.446 1.00 20.50 C +ATOM 601 O LEU A 80 5.997 53.210 16.777 1.00 19.42 O +ATOM 602 CB LEU A 80 9.054 52.878 15.740 1.00 19.52 C +ATOM 603 CG LEU A 80 10.550 52.569 15.948 1.00 19.77 C +ATOM 604 CD1 LEU A 80 11.033 51.619 14.875 1.00 18.38 C +ATOM 605 CD2 LEU A 80 11.365 53.875 15.950 1.00 18.69 C +ATOM 606 N LEU A 81 6.753 55.018 15.663 1.00 21.45 N +ATOM 607 CA LEU A 81 5.481 55.415 15.076 1.00 21.99 C +ATOM 608 C LEU A 81 4.960 54.399 14.062 1.00 21.60 C +ATOM 609 O LEU A 81 5.681 54.045 13.128 1.00 21.18 O +ATOM 610 CB LEU A 81 5.765 56.717 14.338 1.00 22.29 C +ATOM 611 CG LEU A 81 4.838 57.896 14.175 1.00 28.01 C +ATOM 612 CD1 LEU A 81 3.889 58.076 15.398 1.00 30.54 C +ATOM 613 CD2 LEU A 81 5.729 59.117 13.976 1.00 30.14 C +ATOM 614 N ALA A 82 3.701 53.961 14.200 1.00 20.50 N +ATOM 615 CA ALA A 82 3.095 53.083 13.205 1.00 20.23 C +ATOM 616 C ALA A 82 3.032 53.805 11.851 1.00 20.71 C +ATOM 617 O ALA A 82 2.606 54.969 11.775 1.00 19.92 O +ATOM 618 CB ALA A 82 1.685 52.621 13.648 1.00 19.13 C +ATOM 619 N GLY A 83 3.473 53.115 10.797 1.00 21.09 N +ATOM 620 CA GLY A 83 3.454 53.652 9.450 1.00 21.60 C +ATOM 621 C GLY A 83 4.756 54.354 9.070 1.00 22.41 C +ATOM 622 O GLY A 83 4.908 54.785 7.922 1.00 22.78 O +ATOM 623 N SER A 84 5.675 54.500 10.026 1.00 21.49 N +ATOM 624 CA SER A 84 7.003 55.049 9.743 1.00 22.62 C +ATOM 625 C SER A 84 7.955 53.963 9.176 1.00 23.06 C +ATOM 626 O SER A 84 7.665 52.766 9.271 1.00 23.25 O +ATOM 627 CB SER A 84 7.612 55.745 10.986 1.00 21.55 C +ATOM 628 OG SER A 84 7.949 54.826 12.039 1.00 21.85 O +ATOM 629 N VAL A 85 9.091 54.414 8.626 1.00 23.53 N +ATOM 630 CA VAL A 85 10.136 53.570 8.060 1.00 22.93 C +ATOM 631 C VAL A 85 11.427 53.725 8.856 1.00 22.89 C +ATOM 632 O VAL A 85 11.826 54.860 9.204 1.00 23.40 O +ATOM 633 CB VAL A 85 10.436 53.956 6.572 1.00 23.72 C +ATOM 634 CG1 VAL A 85 11.236 52.843 5.886 1.00 23.82 C +ATOM 635 CG2 VAL A 85 9.154 54.114 5.810 1.00 23.40 C +ATOM 636 N VAL A 86 12.073 52.594 9.143 1.00 21.59 N +ATOM 637 CA VAL A 86 13.346 52.564 9.868 1.00 21.61 C +ATOM 638 C VAL A 86 14.397 51.698 9.102 1.00 22.02 C +ATOM 639 O VAL A 86 14.128 50.570 8.703 1.00 21.87 O +ATOM 640 CB VAL A 86 13.192 52.095 11.360 1.00 21.44 C +ATOM 641 CG1 VAL A 86 12.660 50.635 11.465 1.00 20.11 C +ATOM 642 CG2 VAL A 86 14.521 52.237 12.127 1.00 19.16 C +ATOM 643 N ARG A 87 15.561 52.278 8.859 1.00 21.94 N +ATOM 644 CA ARG A 87 16.701 51.555 8.303 1.00 22.74 C +ATOM 645 C ARG A 87 17.227 50.629 9.390 1.00 22.19 C +ATOM 646 O ARG A 87 17.477 51.113 10.489 1.00 22.02 O +ATOM 647 CB ARG A 87 17.783 52.582 7.935 1.00 23.60 C +ATOM 648 CG ARG A 87 18.974 51.991 7.197 1.00 23.36 C +ATOM 649 CD ARG A 87 19.981 53.075 6.916 1.00 25.35 C +ATOM 650 NE ARG A 87 21.014 52.623 5.994 1.00 26.55 N +ATOM 651 CZ ARG A 87 22.042 53.356 5.581 1.00 30.00 C +ATOM 652 NH1 ARG A 87 22.199 54.589 6.009 1.00 30.00 N +ATOM 653 NH2 ARG A 87 22.922 52.846 4.730 1.00 29.59 N +ATOM 654 N ALA A 88 17.362 49.318 9.097 1.00 21.61 N +ATOM 655 CA ALA A 88 17.679 48.293 10.097 1.00 20.95 C +ATOM 656 C ALA A 88 18.751 47.274 9.647 1.00 21.61 C +ATOM 657 O ALA A 88 19.144 47.220 8.463 1.00 21.00 O +ATOM 658 CB ALA A 88 16.418 47.553 10.513 1.00 21.45 C +ATOM 659 N ARG A 89 19.239 46.501 10.616 1.00 21.20 N +ATOM 660 CA ARG A 89 20.154 45.376 10.373 1.00 21.57 C +ATOM 661 C ARG A 89 19.695 44.194 11.214 1.00 21.96 C +ATOM 662 O ARG A 89 19.012 44.373 12.257 1.00 21.50 O +ATOM 663 CB ARG A 89 21.613 45.764 10.731 1.00 20.98 C +ATOM 664 CG ARG A 89 21.869 45.980 12.223 1.00 19.77 C +ATOM 665 CD ARG A 89 23.319 46.440 12.496 1.00 21.57 C +ATOM 666 NE ARG A 89 23.500 46.936 13.863 1.00 20.57 N +ATOM 667 CZ ARG A 89 23.630 46.151 14.929 1.00 21.84 C +ATOM 668 NH1 ARG A 89 23.633 44.840 14.798 1.00 19.04 N +ATOM 669 NH2 ARG A 89 23.774 46.671 16.132 1.00 24.53 N +ATOM 670 N ALA A 90 20.093 42.985 10.816 1.00 22.44 N +ATOM 671 CA ALA A 90 19.509 41.774 11.382 1.00 23.02 C +ATOM 672 C ALA A 90 20.309 41.265 12.545 1.00 23.69 C +ATOM 673 O ALA A 90 21.524 41.444 12.591 1.00 24.80 O +ATOM 674 CB ALA A 90 19.382 40.685 10.333 1.00 23.51 C +ATOM 675 N LEU A 91 19.625 40.629 13.495 1.00 24.22 N +ATOM 676 CA LEU A 91 20.296 39.970 14.629 1.00 24.39 C +ATOM 677 C LEU A 91 20.118 38.460 14.517 1.00 24.55 C +ATOM 678 O LEU A 91 20.957 37.687 15.007 1.00 25.20 O +ATOM 679 CB LEU A 91 19.727 40.438 15.986 1.00 23.48 C +ATOM 680 CG LEU A 91 19.877 41.904 16.414 1.00 22.92 C +ATOM 681 CD1 LEU A 91 19.353 42.033 17.849 1.00 22.77 C +ATOM 682 CD2 LEU A 91 21.316 42.376 16.328 1.00 23.57 C +ATOM 683 N GLY A 92 19.021 38.032 13.890 1.00 25.11 N +ATOM 684 CA GLY A 92 18.676 36.607 13.886 1.00 24.76 C +ATOM 685 C GLY A 92 17.206 36.405 13.589 1.00 25.72 C +ATOM 686 O GLY A 92 16.566 37.253 12.962 1.00 24.40 O +ATOM 687 N MET A 93 16.646 35.283 14.026 1.00 26.58 N +ATOM 688 CA MET A 93 15.233 35.027 13.722 1.00 28.72 C +ATOM 689 C MET A 93 14.593 34.024 14.653 1.00 28.92 C +ATOM 690 O MET A 93 15.277 33.173 15.231 1.00 29.48 O +ATOM 691 CB MET A 93 15.019 34.623 12.238 1.00 29.18 C +ATOM 692 CG MET A 93 15.660 33.304 11.809 1.00 33.11 C +ATOM 693 SD MET A 93 15.636 33.076 9.990 1.00 40.50 S +ATOM 694 CE MET A 93 13.962 32.560 9.708 1.00 37.67 C +ATOM 695 N LEU A 94 13.278 34.144 14.810 1.00 29.01 N +ATOM 696 CA LEU A 94 12.506 33.156 15.553 1.00 30.00 C +ATOM 697 C LEU A 94 11.801 32.247 14.556 1.00 30.90 C +ATOM 698 O LEU A 94 11.070 32.735 13.699 1.00 30.26 O +ATOM 699 CB LEU A 94 11.484 33.838 16.460 1.00 29.19 C +ATOM 700 CG LEU A 94 10.751 32.998 17.514 1.00 30.25 C +ATOM 701 CD1 LEU A 94 11.717 32.305 18.452 1.00 29.45 C +ATOM 702 CD2 LEU A 94 9.800 33.894 18.320 1.00 28.35 C +ATOM 703 N LYS A 95 12.034 30.934 14.648 1.00 32.44 N +ATOM 704 CA LYS A 95 11.368 29.980 13.755 1.00 34.21 C +ATOM 705 C LYS A 95 10.137 29.384 14.420 1.00 34.50 C +ATOM 706 O LYS A 95 10.183 28.971 15.569 1.00 33.94 O +ATOM 707 CB LYS A 95 12.338 28.865 13.332 1.00 35.22 C +ATOM 708 CG LYS A 95 13.401 29.320 12.297 1.00 38.73 C +ATOM 709 CD LYS A 95 14.737 28.595 12.495 1.00 44.84 C +ATOM 710 CE LYS A 95 14.583 27.069 12.322 1.00 48.49 C +ATOM 711 NZ LYS A 95 15.502 26.237 13.209 1.00 50.26 N +ATOM 712 N MET A 96 9.029 29.351 13.698 1.00 35.87 N +ATOM 713 CA MET A 96 7.770 28.871 14.259 1.00 37.62 C +ATOM 714 C MET A 96 6.990 28.206 13.144 1.00 38.88 C +ATOM 715 O MET A 96 7.303 28.406 11.969 1.00 38.99 O +ATOM 716 CB MET A 96 6.915 30.046 14.783 1.00 36.87 C +ATOM 717 CG MET A 96 7.445 30.766 16.014 1.00 36.05 C +ATOM 718 SD MET A 96 6.661 32.397 16.227 1.00 32.47 S +ATOM 719 CE MET A 96 7.289 33.359 14.839 1.00 33.43 C +ATOM 720 N THR A 97 5.953 27.458 13.519 1.00 40.89 N +ATOM 721 CA THR A 97 4.894 27.078 12.584 1.00 43.05 C +ATOM 722 C THR A 97 3.560 27.461 13.229 1.00 43.77 C +ATOM 723 O THR A 97 3.380 27.280 14.438 1.00 44.35 O +ATOM 724 CB THR A 97 4.920 25.547 12.208 1.00 43.28 C +ATOM 725 OG1 THR A 97 5.127 24.765 13.384 1.00 45.70 O +ATOM 726 CG2 THR A 97 6.061 25.231 11.257 1.00 43.69 C +ATOM 727 N ASP A 98 2.644 28.028 12.446 1.00 44.41 N +ATOM 728 CA ASP A 98 1.321 28.342 12.967 1.00 45.30 C +ATOM 729 C ASP A 98 0.228 27.653 12.151 1.00 46.22 C +ATOM 730 O ASP A 98 0.517 26.775 11.331 1.00 46.61 O +ATOM 731 CB ASP A 98 1.088 29.858 13.021 1.00 45.20 C +ATOM 732 CG ASP A 98 0.949 30.472 11.652 1.00 45.80 C +ATOM 733 OD1 ASP A 98 1.027 29.722 10.662 1.00 45.37 O +ATOM 734 OD2 ASP A 98 0.764 31.704 11.562 1.00 44.84 O +ATOM 735 N GLU A 99 -1.028 28.042 12.377 1.00 46.47 N +ATOM 736 CA GLU A 99 -2.141 27.402 11.687 1.00 46.80 C +ATOM 737 C GLU A 99 -2.006 27.467 10.147 1.00 47.27 C +ATOM 738 O GLU A 99 -2.538 26.623 9.442 1.00 47.92 O +ATOM 739 CB GLU A 99 -3.483 27.973 12.161 1.00 45.98 C +ATOM 740 CG GLU A 99 -3.807 29.333 11.593 1.00 44.99 C +ATOM 741 CD GLU A 99 -3.196 30.497 12.389 1.00 42.89 C +ATOM 742 OE1 GLU A 99 -3.428 31.661 11.987 1.00 42.58 O +ATOM 743 OE2 GLU A 99 -2.503 30.248 13.405 1.00 41.44 O +ATOM 744 N SER A 100 -1.279 28.448 9.624 1.00 47.51 N +ATOM 745 CA SER A 100 -1.091 28.565 8.177 1.00 47.27 C +ATOM 746 C SER A 100 0.262 28.046 7.694 1.00 47.08 C +ATOM 747 O SER A 100 0.694 28.388 6.592 1.00 47.42 O +ATOM 748 CB SER A 100 -1.245 30.025 7.730 1.00 47.15 C +ATOM 749 OG SER A 100 -2.525 30.535 8.068 1.00 48.79 O +ATOM 750 N GLY A 101 0.939 27.237 8.507 1.00 46.73 N +ATOM 751 CA GLY A 101 2.222 26.653 8.110 1.00 45.72 C +ATOM 752 C GLY A 101 3.430 27.411 8.650 1.00 45.34 C +ATOM 753 O GLY A 101 3.320 28.159 9.633 1.00 45.08 O +ATOM 754 N VAL A 102 4.585 27.222 8.008 1.00 44.18 N +ATOM 755 CA VAL A 102 5.851 27.802 8.476 1.00 43.13 C +ATOM 756 C VAL A 102 5.795 29.319 8.668 1.00 42.11 C +ATOM 757 O VAL A 102 5.204 30.039 7.858 1.00 41.60 O +ATOM 758 CB VAL A 102 7.015 27.444 7.524 1.00 43.66 C +ATOM 759 CG1 VAL A 102 8.164 28.428 7.684 1.00 43.30 C +ATOM 760 CG2 VAL A 102 7.488 25.988 7.764 1.00 43.78 C +ATOM 761 N ASP A 103 6.415 29.804 9.744 1.00 41.05 N +ATOM 762 CA ASP A 103 6.375 31.242 10.062 1.00 39.44 C +ATOM 763 C ASP A 103 7.649 31.697 10.761 1.00 37.83 C +ATOM 764 O ASP A 103 7.784 31.562 11.973 1.00 38.58 O +ATOM 765 CB ASP A 103 5.182 31.541 10.962 1.00 39.54 C +ATOM 766 CG ASP A 103 4.926 33.029 11.126 1.00 40.16 C +ATOM 767 OD1 ASP A 103 5.544 33.843 10.396 1.00 42.27 O +ATOM 768 OD2 ASP A 103 4.081 33.379 11.977 1.00 38.14 O +ATOM 769 N ALA A 104 8.591 32.226 9.995 1.00 35.52 N +ATOM 770 CA ALA A 104 9.799 32.789 10.562 1.00 32.80 C +ATOM 771 C ALA A 104 9.611 34.300 10.727 1.00 30.91 C +ATOM 772 O ALA A 104 9.037 34.959 9.857 1.00 30.17 O +ATOM 773 CB ALA A 104 10.955 32.514 9.651 1.00 33.11 C +ATOM 774 N LYS A 105 10.079 34.838 11.847 1.00 29.57 N +ATOM 775 CA LYS A 105 10.147 36.293 12.036 1.00 28.05 C +ATOM 776 C LYS A 105 11.562 36.720 12.391 1.00 27.06 C +ATOM 777 O LYS A 105 12.174 36.150 13.289 1.00 27.14 O +ATOM 778 CB LYS A 105 9.142 36.750 13.090 1.00 27.30 C +ATOM 779 CG LYS A 105 7.712 36.235 12.749 1.00 27.03 C +ATOM 780 CD LYS A 105 6.645 37.016 13.447 1.00 26.83 C +ATOM 781 CE LYS A 105 5.287 36.300 13.367 1.00 24.94 C +ATOM 782 NZ LYS A 105 4.698 36.387 11.996 1.00 23.03 N +ATOM 783 N LEU A 106 12.058 37.734 11.691 1.00 25.68 N +ATOM 784 CA LEU A 106 13.374 38.275 11.962 1.00 25.87 C +ATOM 785 C LEU A 106 13.354 39.143 13.222 1.00 25.22 C +ATOM 786 O LEU A 106 12.314 39.719 13.598 1.00 24.89 O +ATOM 787 CB LEU A 106 13.857 39.118 10.784 1.00 25.38 C +ATOM 788 CG LEU A 106 14.443 38.394 9.564 1.00 27.94 C +ATOM 789 CD1 LEU A 106 13.727 37.094 9.184 1.00 27.95 C +ATOM 790 CD2 LEU A 106 14.567 39.332 8.388 1.00 26.61 C +ATOM 791 N VAL A 107 14.523 39.257 13.838 1.00 23.51 N +ATOM 792 CA VAL A 107 14.716 40.131 14.964 1.00 22.73 C +ATOM 793 C VAL A 107 15.811 41.090 14.512 1.00 22.68 C +ATOM 794 O VAL A 107 16.854 40.661 14.003 1.00 22.46 O +ATOM 795 CB VAL A 107 15.080 39.338 16.238 1.00 22.27 C +ATOM 796 CG1 VAL A 107 15.343 40.270 17.373 1.00 22.46 C +ATOM 797 CG2 VAL A 107 13.939 38.318 16.594 1.00 23.92 C +ATOM 798 N ALA A 108 15.553 42.392 14.645 1.00 21.45 N +ATOM 799 CA ALA A 108 16.439 43.391 14.095 1.00 20.74 C +ATOM 800 C ALA A 108 16.607 44.559 15.068 1.00 21.23 C +ATOM 801 O ALA A 108 15.871 44.634 16.070 1.00 21.11 O +ATOM 802 CB ALA A 108 15.903 43.883 12.721 1.00 19.22 C +ATOM 803 N VAL A 109 17.600 45.423 14.790 1.00 20.09 N +ATOM 804 CA VAL A 109 17.739 46.729 15.426 1.00 21.46 C +ATOM 805 C VAL A 109 17.973 47.762 14.319 1.00 21.87 C +ATOM 806 O VAL A 109 18.314 47.381 13.202 1.00 21.72 O +ATOM 807 CB VAL A 109 18.928 46.784 16.409 1.00 20.91 C +ATOM 808 CG1 VAL A 109 18.614 46.011 17.652 1.00 20.05 C +ATOM 809 CG2 VAL A 109 20.208 46.218 15.733 1.00 22.26 C +ATOM 810 N PRO A 110 17.804 49.068 14.626 1.00 22.19 N +ATOM 811 CA PRO A 110 18.094 50.056 13.594 1.00 22.34 C +ATOM 812 C PRO A 110 19.597 50.067 13.216 1.00 23.74 C +ATOM 813 O PRO A 110 20.435 49.546 13.963 1.00 23.41 O +ATOM 814 CB PRO A 110 17.717 51.405 14.280 1.00 22.83 C +ATOM 815 CG PRO A 110 16.791 51.058 15.399 1.00 21.11 C +ATOM 816 CD PRO A 110 17.289 49.695 15.870 1.00 21.07 C +ATOM 817 N HIS A 111 19.905 50.663 12.062 1.00 24.43 N +ATOM 818 CA HIS A 111 21.269 51.039 11.680 1.00 25.10 C +ATOM 819 C HIS A 111 21.948 51.765 12.839 1.00 25.61 C +ATOM 820 O HIS A 111 21.322 52.588 13.518 1.00 26.10 O +ATOM 821 CB HIS A 111 21.182 51.975 10.450 1.00 24.91 C +ATOM 822 CG HIS A 111 22.509 52.407 9.893 1.00 26.79 C +ATOM 823 ND1 HIS A 111 23.070 51.820 8.770 1.00 29.91 N +ATOM 824 CD2 HIS A 111 23.393 53.348 10.305 1.00 23.68 C +ATOM 825 CE1 HIS A 111 24.235 52.393 8.514 1.00 26.42 C +ATOM 826 NE2 HIS A 111 24.442 53.336 9.416 1.00 26.73 N +ATOM 827 N ASP A 112 23.234 51.504 13.051 1.00 25.54 N +ATOM 828 CA ASP A 112 23.979 52.129 14.147 1.00 25.57 C +ATOM 829 C ASP A 112 23.942 53.667 14.222 1.00 25.64 C +ATOM 830 O ASP A 112 24.009 54.219 15.303 1.00 25.60 O +ATOM 831 CB ASP A 112 25.433 51.655 14.148 1.00 26.15 C +ATOM 832 CG ASP A 112 25.577 50.191 14.586 1.00 25.67 C +ATOM 833 OD1 ASP A 112 24.592 49.558 15.018 1.00 29.82 O +ATOM 834 OD2 ASP A 112 26.687 49.675 14.528 1.00 26.95 O +ATOM 835 N LYS A 113 23.866 54.355 13.095 1.00 25.60 N +ATOM 836 CA LYS A 113 23.786 55.819 13.100 1.00 26.31 C +ATOM 837 C LYS A 113 22.358 56.299 13.405 1.00 26.01 C +ATOM 838 O LYS A 113 22.150 57.398 13.891 1.00 27.30 O +ATOM 839 CB LYS A 113 24.288 56.390 11.768 1.00 26.96 C +ATOM 840 N VAL A 114 21.370 55.453 13.158 1.00 25.69 N +ATOM 841 CA VAL A 114 19.998 55.764 13.562 1.00 24.61 C +ATOM 842 C VAL A 114 19.806 55.525 15.065 1.00 25.10 C +ATOM 843 O VAL A 114 19.249 56.379 15.773 1.00 24.38 O +ATOM 844 CB VAL A 114 19.001 54.950 12.751 1.00 25.32 C +ATOM 845 CG1 VAL A 114 17.528 55.198 13.246 1.00 23.89 C +ATOM 846 CG2 VAL A 114 19.202 55.234 11.260 1.00 22.62 C +ATOM 847 N CYS A 115 20.318 54.395 15.563 1.00 24.30 N +ATOM 848 CA CYS A 115 20.191 54.054 16.978 1.00 24.45 C +ATOM 849 C CYS A 115 21.523 53.611 17.614 1.00 25.28 C +ATOM 850 O CYS A 115 21.821 52.409 17.705 1.00 25.35 O +ATOM 851 CB CYS A 115 19.111 52.977 17.168 1.00 24.20 C +ATOM 852 SG CYS A 115 18.644 52.733 18.908 1.00 23.28 S +ATOM 853 N PRO A 116 22.343 54.583 18.036 1.00 25.64 N +ATOM 854 CA PRO A 116 23.601 54.246 18.715 1.00 25.83 C +ATOM 855 C PRO A 116 23.382 53.386 19.946 1.00 26.76 C +ATOM 856 O PRO A 116 24.274 52.606 20.303 1.00 27.28 O +ATOM 857 CB PRO A 116 24.150 55.613 19.142 1.00 25.73 C +ATOM 858 CG PRO A 116 23.576 56.573 18.005 1.00 26.37 C +ATOM 859 CD PRO A 116 22.177 56.038 17.826 1.00 24.59 C +ATOM 860 N MET A 117 22.213 53.510 20.569 1.00 25.92 N +ATOM 861 CA MET A 117 21.880 52.798 21.806 1.00 25.99 C +ATOM 862 C MET A 117 21.872 51.286 21.630 1.00 26.46 C +ATOM 863 O MET A 117 22.001 50.553 22.613 1.00 25.60 O +ATOM 864 CB MET A 117 20.492 53.211 22.307 1.00 25.61 C +ATOM 865 CG MET A 117 20.329 54.735 22.551 1.00 25.77 C +ATOM 866 SD MET A 117 19.862 55.666 21.073 1.00 23.51 S +ATOM 867 CE MET A 117 20.351 57.314 21.549 1.00 23.67 C +ATOM 868 N THR A 118 21.643 50.816 20.396 1.00 26.44 N +ATOM 869 CA THR A 118 21.572 49.368 20.159 1.00 26.45 C +ATOM 870 C THR A 118 22.833 48.825 19.435 1.00 26.58 C +ATOM 871 O THR A 118 22.882 47.643 19.071 1.00 25.87 O +ATOM 872 CB THR A 118 20.255 48.931 19.388 1.00 26.23 C +ATOM 873 OG1 THR A 118 20.061 49.752 18.255 1.00 25.67 O +ATOM 874 CG2 THR A 118 18.975 49.004 20.277 1.00 24.93 C +ATOM 875 N ALA A 119 23.848 49.673 19.264 1.00 26.81 N +ATOM 876 CA ALA A 119 25.069 49.285 18.509 1.00 27.89 C +ATOM 877 C ALA A 119 25.785 48.057 19.057 1.00 28.60 C +ATOM 878 O ALA A 119 26.365 47.295 18.299 1.00 28.79 O +ATOM 879 CB ALA A 119 26.024 50.442 18.375 1.00 27.47 C +ATOM 880 N ASN A 120 25.712 47.837 20.364 1.00 30.19 N +ATOM 881 CA ASN A 120 26.394 46.697 20.978 1.00 31.83 C +ATOM 882 C ASN A 120 25.633 45.400 20.871 1.00 31.62 C +ATOM 883 O ASN A 120 26.124 44.389 21.335 1.00 30.93 O +ATOM 884 CB ASN A 120 26.733 46.965 22.447 1.00 33.05 C +ATOM 885 CG ASN A 120 27.805 48.055 22.605 1.00 38.99 C +ATOM 886 OD1 ASN A 120 28.787 48.097 21.842 1.00 44.64 O +ATOM 887 ND2 ASN A 120 27.610 48.953 23.578 1.00 43.69 N +ATOM 888 N LEU A 121 24.427 45.424 20.298 1.00 30.32 N +ATOM 889 CA LEU A 121 23.756 44.177 19.945 1.00 30.28 C +ATOM 890 C LEU A 121 24.232 43.750 18.545 1.00 30.14 C +ATOM 891 O LEU A 121 23.838 44.354 17.529 1.00 29.66 O +ATOM 892 CB LEU A 121 22.221 44.314 19.994 1.00 29.43 C +ATOM 893 CG LEU A 121 21.655 44.833 21.312 1.00 29.47 C +ATOM 894 CD1 LEU A 121 20.133 45.148 21.240 1.00 28.60 C +ATOM 895 CD2 LEU A 121 21.981 43.867 22.439 1.00 30.01 C +ATOM 896 N LYS A 122 25.104 42.739 18.514 1.00 30.23 N +ATOM 897 CA LYS A 122 25.692 42.242 17.272 1.00 30.77 C +ATOM 898 C LYS A 122 24.963 41.015 16.720 1.00 30.31 C +ATOM 899 O LYS A 122 24.994 40.748 15.520 1.00 30.97 O +ATOM 900 CB LYS A 122 27.150 41.856 17.492 1.00 31.10 C +ATOM 901 CG LYS A 122 27.932 42.857 18.270 1.00 34.55 C +ATOM 902 CD LYS A 122 28.254 44.068 17.435 1.00 37.21 C +ATOM 903 CE LYS A 122 29.578 44.637 17.921 1.00 41.85 C +ATOM 904 NZ LYS A 122 29.647 46.122 17.779 1.00 45.04 N +ATOM 905 N SER A 123 24.353 40.234 17.590 1.00 28.89 N +ATOM 906 CA SER A 123 23.593 39.080 17.119 1.00 29.25 C +ATOM 907 C SER A 123 22.504 38.756 18.130 1.00 29.01 C +ATOM 908 O SER A 123 22.439 39.361 19.199 1.00 29.07 O +ATOM 909 CB SER A 123 24.514 37.847 16.919 1.00 28.38 C +ATOM 910 OG SER A 123 24.909 37.328 18.187 1.00 30.05 O +ATOM 911 N ILE A 124 21.657 37.797 17.779 1.00 30.11 N +ATOM 912 CA ILE A 124 20.560 37.354 18.616 1.00 30.40 C +ATOM 913 C ILE A 124 21.044 36.980 20.043 1.00 31.66 C +ATOM 914 O ILE A 124 20.308 37.162 21.020 1.00 30.63 O +ATOM 915 CB ILE A 124 19.830 36.168 17.921 1.00 30.97 C +ATOM 916 CG1 ILE A 124 18.526 35.811 18.648 1.00 31.32 C +ATOM 917 CG2 ILE A 124 20.760 34.954 17.775 1.00 29.74 C +ATOM 918 CD1 ILE A 124 17.435 36.836 18.440 1.00 33.00 C +ATOM 919 N ASP A 125 22.286 36.472 20.155 1.00 32.15 N +ATOM 920 CA ASP A 125 22.858 36.041 21.449 1.00 32.32 C +ATOM 921 C ASP A 125 23.117 37.191 22.390 1.00 31.43 C +ATOM 922 O ASP A 125 23.291 36.996 23.591 1.00 30.73 O +ATOM 923 CB ASP A 125 24.180 35.287 21.239 1.00 33.54 C +ATOM 924 CG ASP A 125 24.027 34.128 20.295 1.00 36.42 C +ATOM 925 OD1 ASP A 125 23.000 33.427 20.372 1.00 38.93 O +ATOM 926 OD2 ASP A 125 24.912 33.948 19.440 1.00 41.72 O +ATOM 927 N ASP A 126 23.151 38.402 21.849 1.00 30.57 N +ATOM 928 CA ASP A 126 23.341 39.566 22.696 1.00 29.73 C +ATOM 929 C ASP A 126 22.028 40.092 23.290 1.00 29.14 C +ATOM 930 O ASP A 126 22.059 40.903 24.202 1.00 28.18 O +ATOM 931 CB ASP A 126 24.023 40.693 21.927 1.00 29.86 C +ATOM 932 CG ASP A 126 25.409 40.308 21.440 1.00 31.45 C +ATOM 933 OD1 ASP A 126 26.168 39.758 22.245 1.00 32.98 O +ATOM 934 OD2 ASP A 126 25.732 40.556 20.265 1.00 29.33 O +ATOM 935 N VAL A 127 20.891 39.663 22.750 1.00 28.12 N +ATOM 936 CA VAL A 127 19.600 40.132 23.270 1.00 27.54 C +ATOM 937 C VAL A 127 19.398 39.543 24.680 1.00 27.24 C +ATOM 938 O VAL A 127 19.603 38.361 24.881 1.00 26.18 O +ATOM 939 CB VAL A 127 18.442 39.723 22.332 1.00 27.46 C +ATOM 940 CG1 VAL A 127 17.094 40.157 22.913 1.00 26.88 C +ATOM 941 CG2 VAL A 127 18.645 40.294 20.923 1.00 27.36 C +ATOM 942 N PRO A 128 19.011 40.375 25.658 1.00 27.18 N +ATOM 943 CA PRO A 128 18.809 39.845 26.999 1.00 27.22 C +ATOM 944 C PRO A 128 17.902 38.614 26.998 1.00 27.86 C +ATOM 945 O PRO A 128 16.919 38.562 26.249 1.00 27.80 O +ATOM 946 CB PRO A 128 18.130 41.002 27.724 1.00 26.62 C +ATOM 947 CG PRO A 128 18.769 42.235 27.104 1.00 28.03 C +ATOM 948 CD PRO A 128 18.898 41.850 25.616 1.00 27.41 C +ATOM 949 N ALA A 129 18.221 37.627 27.834 1.00 27.80 N +ATOM 950 CA ALA A 129 17.410 36.415 27.870 1.00 28.35 C +ATOM 951 C ALA A 129 15.934 36.714 28.217 1.00 28.08 C +ATOM 952 O ALA A 129 15.010 36.049 27.696 1.00 27.99 O +ATOM 953 CB ALA A 129 18.005 35.402 28.850 1.00 28.21 C +ATOM 954 N TYR A 130 15.720 37.696 29.098 1.00 27.53 N +ATOM 955 CA TYR A 130 14.362 38.016 29.546 1.00 27.52 C +ATOM 956 C TYR A 130 13.523 38.512 28.358 1.00 27.66 C +ATOM 957 O TYR A 130 12.357 38.146 28.241 1.00 27.90 O +ATOM 958 CB TYR A 130 14.350 39.024 30.720 1.00 27.57 C +ATOM 959 CG TYR A 130 14.359 40.464 30.262 1.00 27.15 C +ATOM 960 CD1 TYR A 130 13.183 41.099 29.871 1.00 29.10 C +ATOM 961 CD2 TYR A 130 15.554 41.175 30.181 1.00 27.46 C +ATOM 962 CE1 TYR A 130 13.203 42.410 29.409 1.00 28.74 C +ATOM 963 CE2 TYR A 130 15.584 42.465 29.730 1.00 28.56 C +ATOM 964 CZ TYR A 130 14.398 43.072 29.348 1.00 29.54 C +ATOM 965 OH TYR A 130 14.443 44.369 28.916 1.00 34.94 O +ATOM 966 N LEU A 131 14.121 39.315 27.477 1.00 27.44 N +ATOM 967 CA LEU A 131 13.440 39.796 26.273 1.00 27.71 C +ATOM 968 C LEU A 131 13.166 38.664 25.271 1.00 27.69 C +ATOM 969 O LEU A 131 12.027 38.483 24.788 1.00 27.08 O +ATOM 970 CB LEU A 131 14.240 40.910 25.608 1.00 27.68 C +ATOM 971 CG LEU A 131 13.453 41.705 24.555 1.00 29.36 C +ATOM 972 CD1 LEU A 131 12.160 42.314 25.137 1.00 28.92 C +ATOM 973 CD2 LEU A 131 14.328 42.790 23.943 1.00 29.57 C +ATOM 974 N LYS A 132 14.211 37.901 24.953 1.00 27.29 N +ATOM 975 CA LYS A 132 14.038 36.681 24.180 1.00 27.37 C +ATOM 976 C LYS A 132 12.846 35.869 24.734 1.00 26.26 C +ATOM 977 O LYS A 132 11.948 35.517 23.986 1.00 26.14 O +ATOM 978 CB LYS A 132 15.336 35.843 24.172 1.00 28.31 C +ATOM 979 CG LYS A 132 16.386 36.314 23.170 1.00 30.56 C +ATOM 980 CD LYS A 132 17.511 35.269 22.990 1.00 33.45 C +ATOM 981 CE LYS A 132 18.727 35.625 23.835 1.00 35.02 C +ATOM 982 NZ LYS A 132 19.939 34.745 23.591 1.00 37.99 N +ATOM 983 N ASP A 133 12.839 35.580 26.034 1.00 25.23 N +ATOM 984 CA ASP A 133 11.757 34.796 26.662 1.00 24.89 C +ATOM 985 C ASP A 133 10.358 35.406 26.531 1.00 24.44 C +ATOM 986 O ASP A 133 9.383 34.687 26.328 1.00 23.26 O +ATOM 987 CB ASP A 133 12.027 34.569 28.159 1.00 24.84 C +ATOM 988 CG ASP A 133 13.166 33.593 28.417 1.00 28.52 C +ATOM 989 OD1 ASP A 133 13.562 32.849 27.490 1.00 31.06 O +ATOM 990 OD2 ASP A 133 13.678 33.593 29.552 1.00 31.64 O +ATOM 991 N GLN A 134 10.272 36.724 26.710 1.00 24.07 N +ATOM 992 CA GLN A 134 9.018 37.455 26.504 1.00 24.53 C +ATOM 993 C GLN A 134 8.504 37.351 25.062 1.00 24.16 C +ATOM 994 O GLN A 134 7.301 37.181 24.843 1.00 23.95 O +ATOM 995 CB GLN A 134 9.182 38.943 26.874 1.00 24.01 C +ATOM 996 CG GLN A 134 9.537 39.176 28.333 1.00 25.53 C +ATOM 997 CD GLN A 134 9.354 40.607 28.741 1.00 25.83 C +ATOM 998 OE1 GLN A 134 9.357 40.934 29.927 1.00 27.07 O +ATOM 999 NE2 GLN A 134 9.165 41.470 27.766 1.00 26.58 N +ATOM 1000 N ILE A 135 9.399 37.479 24.086 1.00 23.99 N +ATOM 1001 CA ILE A 135 8.997 37.405 22.674 1.00 24.11 C +ATOM 1002 C ILE A 135 8.444 36.023 22.366 1.00 25.38 C +ATOM 1003 O ILE A 135 7.381 35.878 21.727 1.00 25.45 O +ATOM 1004 CB ILE A 135 10.163 37.749 21.719 1.00 24.40 C +ATOM 1005 CG1 ILE A 135 10.565 39.216 21.892 1.00 23.65 C +ATOM 1006 CG2 ILE A 135 9.834 37.373 20.230 1.00 20.81 C +ATOM 1007 CD1 ILE A 135 11.932 39.561 21.290 1.00 21.20 C +ATOM 1008 N LYS A 136 9.138 35.006 22.859 1.00 25.73 N +ATOM 1009 CA LYS A 136 8.711 33.639 22.643 1.00 26.35 C +ATOM 1010 C LYS A 136 7.365 33.315 23.315 1.00 25.70 C +ATOM 1011 O LYS A 136 6.482 32.730 22.684 1.00 24.73 O +ATOM 1012 CB LYS A 136 9.839 32.696 23.079 1.00 27.12 C +ATOM 1013 CG LYS A 136 9.491 31.210 23.059 1.00 30.98 C +ATOM 1014 CD LYS A 136 10.754 30.398 23.454 1.00 38.08 C +ATOM 1015 CE LYS A 136 10.456 28.907 23.637 1.00 40.93 C +ATOM 1016 NZ LYS A 136 9.113 28.719 24.265 1.00 44.61 N +ATOM 1017 N HIS A 137 7.192 33.740 24.575 1.00 25.25 N +ATOM 1018 CA HIS A 137 5.900 33.625 25.278 1.00 24.60 C +ATOM 1019 C HIS A 137 4.757 34.338 24.511 1.00 23.92 C +ATOM 1020 O HIS A 137 3.645 33.784 24.345 1.00 23.75 O +ATOM 1021 CB HIS A 137 6.011 34.201 26.735 1.00 24.77 C +ATOM 1022 CG HIS A 137 4.761 34.005 27.551 1.00 25.29 C +ATOM 1023 ND1 HIS A 137 3.872 35.028 27.824 1.00 25.11 N +ATOM 1024 CD2 HIS A 137 4.228 32.888 28.111 1.00 22.39 C +ATOM 1025 CE1 HIS A 137 2.856 34.556 28.526 1.00 22.79 C +ATOM 1026 NE2 HIS A 137 3.047 33.259 28.714 1.00 26.13 N +ATOM 1027 N PHE A 138 5.022 35.573 24.066 1.00 23.23 N +ATOM 1028 CA PHE A 138 4.054 36.330 23.261 1.00 23.01 C +ATOM 1029 C PHE A 138 3.523 35.499 22.087 1.00 23.59 C +ATOM 1030 O PHE A 138 2.313 35.315 21.948 1.00 22.99 O +ATOM 1031 CB PHE A 138 4.588 37.688 22.737 1.00 21.76 C +ATOM 1032 CG PHE A 138 3.581 38.410 21.879 1.00 22.65 C +ATOM 1033 CD1 PHE A 138 2.538 39.114 22.458 1.00 20.19 C +ATOM 1034 CD2 PHE A 138 3.626 38.326 20.481 1.00 22.75 C +ATOM 1035 CE1 PHE A 138 1.566 39.746 21.672 1.00 20.14 C +ATOM 1036 CE2 PHE A 138 2.661 38.960 19.693 1.00 18.78 C +ATOM 1037 CZ PHE A 138 1.624 39.658 20.306 1.00 18.64 C +ATOM 1038 N PHE A 139 4.418 34.995 21.238 1.00 24.32 N +ATOM 1039 CA PHE A 139 3.966 34.206 20.091 1.00 25.35 C +ATOM 1040 C PHE A 139 3.302 32.873 20.431 1.00 26.07 C +ATOM 1041 O PHE A 139 2.369 32.435 19.751 1.00 26.11 O +ATOM 1042 CB PHE A 139 5.084 34.060 19.068 1.00 25.90 C +ATOM 1043 CG PHE A 139 5.393 35.342 18.370 1.00 27.31 C +ATOM 1044 CD1 PHE A 139 4.535 35.827 17.393 1.00 27.14 C +ATOM 1045 CD2 PHE A 139 6.515 36.088 18.718 1.00 26.77 C +ATOM 1046 CE1 PHE A 139 4.796 37.021 16.763 1.00 26.81 C +ATOM 1047 CE2 PHE A 139 6.786 37.279 18.088 1.00 27.38 C +ATOM 1048 CZ PHE A 139 5.915 37.750 17.096 1.00 27.03 C +ATOM 1049 N GLU A 140 3.747 32.247 21.508 1.00 27.11 N +ATOM 1050 CA GLU A 140 3.095 31.047 22.009 1.00 28.38 C +ATOM 1051 C GLU A 140 1.679 31.261 22.518 1.00 27.76 C +ATOM 1052 O GLU A 140 0.889 30.341 22.460 1.00 28.49 O +ATOM 1053 CB GLU A 140 3.937 30.396 23.110 1.00 28.39 C +ATOM 1054 CG GLU A 140 5.150 29.725 22.513 1.00 32.77 C +ATOM 1055 CD GLU A 140 5.926 28.953 23.534 1.00 35.86 C +ATOM 1056 OE1 GLU A 140 5.978 29.397 24.707 1.00 36.53 O +ATOM 1057 OE2 GLU A 140 6.491 27.914 23.149 1.00 38.06 O +ATOM 1058 N GLN A 141 1.358 32.463 22.996 1.00 27.27 N +ATOM 1059 CA GLN A 141 0.098 32.706 23.718 1.00 26.49 C +ATOM 1060 C GLN A 141 -0.891 33.712 23.103 1.00 26.43 C +ATOM 1061 O GLN A 141 -2.081 33.621 23.367 1.00 26.26 O +ATOM 1062 CB GLN A 141 0.390 33.129 25.170 1.00 26.70 C +ATOM 1063 CG GLN A 141 1.054 32.012 26.000 1.00 25.87 C +ATOM 1064 CD GLN A 141 0.143 30.811 26.137 1.00 27.04 C +ATOM 1065 OE1 GLN A 141 -1.078 30.964 26.127 1.00 26.18 O +ATOM 1066 NE2 GLN A 141 0.725 29.604 26.246 1.00 24.08 N +ATOM 1067 N TYR A 142 -0.431 34.650 22.283 1.00 25.24 N +ATOM 1068 CA TYR A 142 -1.324 35.723 21.835 1.00 25.93 C +ATOM 1069 C TYR A 142 -2.589 35.291 21.046 1.00 26.85 C +ATOM 1070 O TYR A 142 -3.600 36.023 21.036 1.00 25.86 O +ATOM 1071 CB TYR A 142 -0.550 36.851 21.122 1.00 24.57 C +ATOM 1072 CG TYR A 142 -0.237 36.657 19.645 1.00 24.88 C +ATOM 1073 CD1 TYR A 142 -0.614 37.636 18.697 1.00 23.74 C +ATOM 1074 CD2 TYR A 142 0.484 35.536 19.189 1.00 23.36 C +ATOM 1075 CE1 TYR A 142 -0.311 37.485 17.323 1.00 24.35 C +ATOM 1076 CE2 TYR A 142 0.795 35.381 17.840 1.00 23.20 C +ATOM 1077 CZ TYR A 142 0.408 36.350 16.908 1.00 24.71 C +ATOM 1078 OH TYR A 142 0.726 36.189 15.570 1.00 23.16 O +ATOM 1079 N LYS A 143 -2.538 34.106 20.425 1.00 27.36 N +ATOM 1080 CA LYS A 143 -3.656 33.620 19.616 1.00 28.59 C +ATOM 1081 C LYS A 143 -4.517 32.628 20.383 1.00 28.24 C +ATOM 1082 O LYS A 143 -5.450 32.069 19.814 1.00 28.26 O +ATOM 1083 CB LYS A 143 -3.179 32.956 18.314 1.00 28.24 C +ATOM 1084 CG LYS A 143 -2.845 33.904 17.177 1.00 30.18 C +ATOM 1085 CD LYS A 143 -2.035 33.123 16.136 1.00 31.30 C +ATOM 1086 CE LYS A 143 -2.057 33.788 14.782 1.00 32.46 C +ATOM 1087 NZ LYS A 143 -1.094 33.108 13.850 1.00 31.69 N +ATOM 1088 N ALA A 144 -4.214 32.446 21.666 1.00 28.11 N +ATOM 1089 CA ALA A 144 -4.911 31.489 22.514 1.00 28.53 C +ATOM 1090 C ALA A 144 -6.436 31.578 22.439 1.00 29.33 C +ATOM 1091 O ALA A 144 -7.109 30.576 22.625 1.00 29.02 O +ATOM 1092 CB ALA A 144 -4.446 31.610 23.979 1.00 27.54 C +ATOM 1093 N LEU A 145 -6.986 32.755 22.160 1.00 30.11 N +ATOM 1094 CA LEU A 145 -8.442 32.926 22.243 1.00 31.34 C +ATOM 1095 C LEU A 145 -9.115 33.091 20.884 1.00 33.19 C +ATOM 1096 O LEU A 145 -10.278 33.527 20.799 1.00 34.02 O +ATOM 1097 CB LEU A 145 -8.836 34.068 23.184 1.00 30.04 C +ATOM 1098 CG LEU A 145 -8.451 33.803 24.646 1.00 29.77 C +ATOM 1099 CD1 LEU A 145 -8.766 35.020 25.539 1.00 27.97 C +ATOM 1100 CD2 LEU A 145 -9.158 32.558 25.178 1.00 28.92 C +ATOM 1101 N GLU A 146 -8.404 32.722 19.826 1.00 34.54 N +ATOM 1102 CA GLU A 146 -9.007 32.685 18.497 1.00 36.61 C +ATOM 1103 C GLU A 146 -9.127 31.241 18.018 1.00 36.98 C +ATOM 1104 O GLU A 146 -8.131 30.520 17.940 1.00 37.28 O +ATOM 1105 CB GLU A 146 -8.198 33.548 17.528 1.00 36.66 C +ATOM 1106 CG GLU A 146 -8.473 35.038 17.752 1.00 39.16 C +ATOM 1107 CD GLU A 146 -7.212 35.867 17.769 1.00 41.76 C +ATOM 1108 OE1 GLU A 146 -6.523 35.925 16.724 1.00 46.57 O +ATOM 1109 OE2 GLU A 146 -6.907 36.480 18.809 1.00 41.40 O +ATOM 1110 N LYS A 147 -10.355 30.810 17.733 1.00 38.45 N +ATOM 1111 CA LYS A 147 -10.597 29.436 17.247 1.00 39.30 C +ATOM 1112 C LYS A 147 -9.881 29.202 15.918 1.00 39.80 C +ATOM 1113 O LYS A 147 -9.942 30.031 15.004 1.00 39.70 O +ATOM 1114 CB LYS A 147 -12.107 29.141 17.099 1.00 39.10 C +ATOM 1115 N GLY A 148 -9.196 28.069 15.813 1.00 40.78 N +ATOM 1116 CA GLY A 148 -8.523 27.724 14.574 1.00 41.89 C +ATOM 1117 C GLY A 148 -7.129 28.302 14.423 1.00 42.81 C +ATOM 1118 O GLY A 148 -6.505 28.152 13.366 1.00 43.25 O +ATOM 1119 N LYS A 149 -6.631 28.970 15.467 1.00 42.74 N +ATOM 1120 CA LYS A 149 -5.309 29.594 15.395 1.00 42.54 C +ATOM 1121 C LYS A 149 -4.401 29.040 16.468 1.00 42.14 C +ATOM 1122 O LYS A 149 -4.838 28.797 17.587 1.00 42.29 O +ATOM 1123 CB LYS A 149 -5.433 31.099 15.551 1.00 42.68 C +ATOM 1124 CG LYS A 149 -6.172 31.762 14.419 1.00 43.87 C +ATOM 1125 CD LYS A 149 -6.153 33.241 14.672 1.00 47.65 C +ATOM 1126 CE LYS A 149 -6.746 34.013 13.534 1.00 49.81 C +ATOM 1127 NZ LYS A 149 -6.712 35.448 13.904 1.00 50.78 N +ATOM 1128 N TRP A 150 -3.132 28.836 16.131 1.00 41.69 N +ATOM 1129 CA TRP A 150 -2.195 28.252 17.077 1.00 41.16 C +ATOM 1130 C TRP A 150 -0.741 28.515 16.617 1.00 40.09 C +ATOM 1131 O TRP A 150 -0.498 28.906 15.467 1.00 39.90 O +ATOM 1132 CB TRP A 150 -2.482 26.751 17.256 1.00 42.09 C +ATOM 1133 CG TRP A 150 -2.424 25.994 15.941 1.00 44.48 C +ATOM 1134 CD1 TRP A 150 -3.473 25.731 15.085 1.00 46.23 C +ATOM 1135 CD2 TRP A 150 -1.253 25.441 15.319 1.00 47.04 C +ATOM 1136 NE1 TRP A 150 -3.018 25.043 13.976 1.00 47.57 N +ATOM 1137 CE2 TRP A 150 -1.664 24.847 14.098 1.00 48.31 C +ATOM 1138 CE3 TRP A 150 0.104 25.389 15.673 1.00 47.74 C +ATOM 1139 CZ2 TRP A 150 -0.759 24.213 13.228 1.00 49.44 C +ATOM 1140 CZ3 TRP A 150 1.004 24.752 14.797 1.00 48.88 C +ATOM 1141 CH2 TRP A 150 0.565 24.178 13.597 1.00 48.25 C +ATOM 1142 N VAL A 151 0.209 28.336 17.527 1.00 38.25 N +ATOM 1143 CA VAL A 151 1.612 28.584 17.228 1.00 37.22 C +ATOM 1144 C VAL A 151 2.497 27.650 18.003 1.00 37.01 C +ATOM 1145 O VAL A 151 2.385 27.567 19.224 1.00 37.18 O +ATOM 1146 CB VAL A 151 2.064 29.984 17.683 1.00 36.92 C +ATOM 1147 CG1 VAL A 151 3.609 30.090 17.614 1.00 36.17 C +ATOM 1148 CG2 VAL A 151 1.374 31.052 16.887 1.00 37.01 C +ATOM 1149 N LYS A 152 3.411 26.983 17.306 1.00 37.00 N +ATOM 1150 CA LYS A 152 4.498 26.276 17.985 1.00 37.07 C +ATOM 1151 C LYS A 152 5.842 26.914 17.600 1.00 36.86 C +ATOM 1152 O LYS A 152 6.130 27.120 16.424 1.00 36.56 O +ATOM 1153 CB LYS A 152 4.462 24.764 17.671 1.00 37.12 C +ATOM 1154 N VAL A 153 6.626 27.265 18.610 1.00 37.55 N +ATOM 1155 CA VAL A 153 7.952 27.825 18.420 1.00 38.67 C +ATOM 1156 C VAL A 153 8.974 26.699 18.221 1.00 39.79 C +ATOM 1157 O VAL A 153 9.112 25.831 19.090 1.00 40.45 O +ATOM 1158 CB VAL A 153 8.383 28.679 19.647 1.00 38.52 C +ATOM 1159 CG1 VAL A 153 9.857 29.052 19.544 1.00 38.07 C +ATOM 1160 CG2 VAL A 153 7.497 29.925 19.786 1.00 37.74 C +ATOM 1161 N GLU A 154 9.687 26.708 17.090 1.00 40.04 N +ATOM 1162 CA GLU A 154 10.734 25.724 16.843 1.00 40.39 C +ATOM 1163 C GLU A 154 12.069 26.146 17.482 1.00 39.58 C +ATOM 1164 O GLU A 154 12.725 25.346 18.138 1.00 39.63 O +ATOM 1165 CB GLU A 154 10.906 25.461 15.339 1.00 40.95 C +ATOM 1166 CG GLU A 154 9.594 25.360 14.525 1.00 44.59 C +ATOM 1167 CD GLU A 154 8.715 24.132 14.863 1.00 51.27 C +ATOM 1168 OE1 GLU A 154 9.167 23.234 15.624 1.00 52.36 O +ATOM 1169 OE2 GLU A 154 7.557 24.071 14.356 1.00 52.58 O +ATOM 1170 N GLY A 155 12.483 27.394 17.293 1.00 38.48 N +ATOM 1171 CA GLY A 155 13.721 27.866 17.929 1.00 37.24 C +ATOM 1172 C GLY A 155 14.311 29.122 17.304 1.00 36.18 C +ATOM 1173 O GLY A 155 13.750 29.666 16.353 1.00 36.76 O +ATOM 1174 N TRP A 156 15.439 29.571 17.847 1.00 34.89 N +ATOM 1175 CA TRP A 156 16.155 30.742 17.367 1.00 34.38 C +ATOM 1176 C TRP A 156 17.174 30.356 16.302 1.00 34.36 C +ATOM 1177 O TRP A 156 17.674 29.239 16.305 1.00 35.16 O +ATOM 1178 CB TRP A 156 16.906 31.397 18.520 1.00 33.47 C +ATOM 1179 CG TRP A 156 16.018 31.843 19.632 1.00 33.27 C +ATOM 1180 CD1 TRP A 156 15.803 31.203 20.822 1.00 33.92 C +ATOM 1181 CD2 TRP A 156 15.201 33.031 19.662 1.00 30.60 C +ATOM 1182 NE1 TRP A 156 14.910 31.924 21.596 1.00 32.30 N +ATOM 1183 CE2 TRP A 156 14.523 33.044 20.909 1.00 31.40 C +ATOM 1184 CE3 TRP A 156 14.973 34.070 18.760 1.00 31.26 C +ATOM 1185 CZ2 TRP A 156 13.630 34.062 21.273 1.00 30.75 C +ATOM 1186 CZ3 TRP A 156 14.095 35.104 19.135 1.00 32.01 C +ATOM 1187 CH2 TRP A 156 13.444 35.090 20.380 1.00 29.67 C +ATOM 1188 N ASP A 157 17.469 31.272 15.386 1.00 33.86 N +ATOM 1189 CA ASP A 157 18.577 31.106 14.437 1.00 32.34 C +ATOM 1190 C ASP A 157 19.263 32.457 14.275 1.00 31.51 C +ATOM 1191 O ASP A 157 18.729 33.478 14.724 1.00 31.36 O +ATOM 1192 CB ASP A 157 18.063 30.581 13.096 1.00 32.87 C +ATOM 1193 CG ASP A 157 19.050 29.623 12.430 1.00 33.29 C +ATOM 1194 OD1 ASP A 157 20.267 29.756 12.646 1.00 34.65 O +ATOM 1195 OD2 ASP A 157 18.612 28.741 11.682 1.00 34.01 O +ATOM 1196 N GLY A 158 20.444 32.474 13.656 1.00 29.77 N +ATOM 1197 CA GLY A 158 21.324 33.641 13.683 1.00 27.83 C +ATOM 1198 C GLY A 158 21.263 34.514 12.449 1.00 27.09 C +ATOM 1199 O GLY A 158 20.326 34.406 11.659 1.00 26.51 O +ATOM 1200 N ILE A 159 22.272 35.374 12.288 1.00 26.02 N +ATOM 1201 CA ILE A 159 22.293 36.402 11.250 1.00 26.35 C +ATOM 1202 C ILE A 159 22.280 35.847 9.827 1.00 26.41 C +ATOM 1203 O ILE A 159 21.581 36.376 8.946 1.00 25.21 O +ATOM 1204 CB ILE A 159 23.504 37.366 11.418 1.00 26.70 C +ATOM 1205 CG1 ILE A 159 23.361 38.233 12.685 1.00 28.08 C +ATOM 1206 CG2 ILE A 159 23.650 38.301 10.246 1.00 26.01 C +ATOM 1207 CD1 ILE A 159 24.668 39.003 13.012 1.00 28.81 C +ATOM 1208 N ASP A 160 23.038 34.772 9.597 1.00 26.15 N +ATOM 1209 CA ASP A 160 23.112 34.177 8.249 1.00 25.96 C +ATOM 1210 C ASP A 160 21.756 33.642 7.817 1.00 24.88 C +ATOM 1211 O ASP A 160 21.374 33.777 6.665 1.00 24.73 O +ATOM 1212 CB ASP A 160 24.116 33.010 8.205 1.00 26.67 C +ATOM 1213 CG ASP A 160 25.541 33.433 8.520 1.00 29.50 C +ATOM 1214 OD1 ASP A 160 25.934 34.574 8.239 1.00 30.48 O +ATOM 1215 OD2 ASP A 160 26.293 32.584 9.050 1.00 35.45 O +ATOM 1216 N ALA A 161 21.032 32.999 8.728 1.00 23.99 N +ATOM 1217 CA ALA A 161 19.680 32.532 8.392 1.00 23.50 C +ATOM 1218 C ALA A 161 18.751 33.702 8.082 1.00 23.21 C +ATOM 1219 O ALA A 161 17.935 33.606 7.165 1.00 24.21 O +ATOM 1220 CB ALA A 161 19.115 31.701 9.495 1.00 23.26 C +ATOM 1221 N ALA A 162 18.894 34.805 8.824 1.00 23.21 N +ATOM 1222 CA ALA A 162 18.103 36.027 8.571 1.00 23.79 C +ATOM 1223 C ALA A 162 18.362 36.572 7.170 1.00 23.81 C +ATOM 1224 O ALA A 162 17.440 36.955 6.439 1.00 23.83 O +ATOM 1225 CB ALA A 162 18.394 37.118 9.643 1.00 22.09 C +ATOM 1226 N HIS A 163 19.642 36.604 6.796 1.00 24.63 N +ATOM 1227 CA HIS A 163 20.029 37.073 5.475 1.00 24.48 C +ATOM 1228 C HIS A 163 19.483 36.211 4.326 1.00 24.40 C +ATOM 1229 O HIS A 163 19.062 36.754 3.319 1.00 24.93 O +ATOM 1230 CB HIS A 163 21.542 37.247 5.411 1.00 24.71 C +ATOM 1231 CG HIS A 163 22.027 38.433 6.186 1.00 24.48 C +ATOM 1232 ND1 HIS A 163 23.346 38.602 6.556 1.00 25.05 N +ATOM 1233 CD2 HIS A 163 21.361 39.517 6.658 1.00 24.82 C +ATOM 1234 CE1 HIS A 163 23.478 39.748 7.207 1.00 26.44 C +ATOM 1235 NE2 HIS A 163 22.286 40.321 7.286 1.00 25.55 N +ATOM 1236 N LYS A 164 19.483 34.885 4.485 1.00 24.88 N +ATOM 1237 CA LYS A 164 18.856 33.977 3.518 1.00 26.27 C +ATOM 1238 C LYS A 164 17.384 34.322 3.344 1.00 25.61 C +ATOM 1239 O LYS A 164 16.892 34.453 2.231 1.00 25.21 O +ATOM 1240 CB LYS A 164 18.864 32.524 4.009 1.00 25.32 C +ATOM 1241 CG LYS A 164 20.048 31.657 3.721 1.00 30.29 C +ATOM 1242 CD LYS A 164 19.613 30.121 3.720 1.00 34.26 C +ATOM 1243 CE LYS A 164 18.052 29.873 3.503 1.00 36.52 C +ATOM 1244 NZ LYS A 164 17.403 29.714 2.102 1.00 34.41 N +ATOM 1245 N GLU A 165 16.667 34.392 4.472 1.00 25.78 N +ATOM 1246 CA GLU A 165 15.244 34.755 4.441 1.00 25.93 C +ATOM 1247 C GLU A 165 15.002 36.070 3.666 1.00 25.03 C +ATOM 1248 O GLU A 165 14.080 36.172 2.864 1.00 25.31 O +ATOM 1249 CB GLU A 165 14.664 34.826 5.886 1.00 26.24 C +ATOM 1250 CG GLU A 165 13.251 35.378 5.967 1.00 28.43 C +ATOM 1251 CD GLU A 165 12.136 34.349 5.679 1.00 34.26 C +ATOM 1252 OE1 GLU A 165 12.441 33.135 5.549 1.00 30.46 O +ATOM 1253 OE2 GLU A 165 10.938 34.777 5.629 1.00 38.23 O +ATOM 1254 N ILE A 166 15.831 37.076 3.918 1.00 25.30 N +ATOM 1255 CA ILE A 166 15.736 38.343 3.199 1.00 25.03 C +ATOM 1256 C ILE A 166 16.037 38.168 1.671 1.00 26.31 C +ATOM 1257 O ILE A 166 15.225 38.577 0.837 1.00 25.19 O +ATOM 1258 CB ILE A 166 16.663 39.415 3.819 1.00 24.79 C +ATOM 1259 CG1 ILE A 166 16.224 39.786 5.264 1.00 23.32 C +ATOM 1260 CG2 ILE A 166 16.705 40.658 2.942 1.00 23.43 C +ATOM 1261 CD1 ILE A 166 17.231 40.715 6.023 1.00 17.43 C +ATOM 1262 N THR A 167 17.178 37.556 1.314 1.00 26.73 N +ATOM 1263 CA THR A 167 17.499 37.327 -0.131 1.00 27.90 C +ATOM 1264 C THR A 167 16.388 36.528 -0.853 1.00 27.76 C +ATOM 1265 O THR A 167 15.948 36.919 -1.928 1.00 27.97 O +ATOM 1266 CB THR A 167 18.896 36.655 -0.343 1.00 27.77 C +ATOM 1267 OG1 THR A 167 19.912 37.462 0.265 1.00 29.19 O +ATOM 1268 CG2 THR A 167 19.220 36.514 -1.852 1.00 28.06 C +ATOM 1269 N ASP A 168 15.910 35.440 -0.241 1.00 28.23 N +ATOM 1270 CA ASP A 168 14.773 34.697 -0.801 1.00 29.21 C +ATOM 1271 C ASP A 168 13.567 35.601 -1.013 1.00 29.51 C +ATOM 1272 O ASP A 168 12.931 35.580 -2.066 1.00 29.99 O +ATOM 1273 CB ASP A 168 14.390 33.492 0.087 1.00 29.78 C +ATOM 1274 CG ASP A 168 15.502 32.434 0.167 1.00 30.95 C +ATOM 1275 OD1 ASP A 168 16.467 32.528 -0.605 1.00 30.65 O +ATOM 1276 OD2 ASP A 168 15.430 31.526 1.015 1.00 33.38 O +ATOM 1277 N GLY A 169 13.244 36.407 -0.004 1.00 29.89 N +ATOM 1278 CA GLY A 169 12.060 37.272 -0.081 1.00 29.50 C +ATOM 1279 C GLY A 169 12.136 38.287 -1.199 1.00 29.28 C +ATOM 1280 O GLY A 169 11.170 38.520 -1.900 1.00 27.96 O +ATOM 1281 N VAL A 170 13.285 38.927 -1.335 1.00 29.71 N +ATOM 1282 CA VAL A 170 13.504 39.857 -2.440 1.00 31.10 C +ATOM 1283 C VAL A 170 13.337 39.173 -3.832 1.00 33.09 C +ATOM 1284 O VAL A 170 12.599 39.672 -4.699 1.00 33.41 O +ATOM 1285 CB VAL A 170 14.887 40.574 -2.309 1.00 30.44 C +ATOM 1286 CG1 VAL A 170 15.188 41.389 -3.551 1.00 29.32 C +ATOM 1287 CG2 VAL A 170 14.898 41.459 -1.071 1.00 29.13 C +ATOM 1288 N ALA A 171 14.016 38.036 -4.018 1.00 34.61 N +ATOM 1289 CA ALA A 171 13.922 37.243 -5.237 1.00 36.15 C +ATOM 1290 C ALA A 171 12.473 36.854 -5.526 1.00 37.93 C +ATOM 1291 O ALA A 171 11.950 37.182 -6.592 1.00 38.85 O +ATOM 1292 CB ALA A 171 14.792 35.993 -5.116 1.00 35.84 C +ATOM 1293 N ASN A 172 11.819 36.168 -4.583 1.00 38.94 N +ATOM 1294 CA ASN A 172 10.408 35.776 -4.743 1.00 40.34 C +ATOM 1295 C ASN A 172 9.461 36.914 -5.139 1.00 40.57 C +ATOM 1296 O ASN A 172 8.516 36.702 -5.886 1.00 40.25 O +ATOM 1297 CB ASN A 172 9.869 35.131 -3.470 1.00 40.63 C +ATOM 1298 CG ASN A 172 10.583 33.848 -3.112 1.00 44.22 C +ATOM 1299 OD1 ASN A 172 11.398 33.318 -3.886 1.00 46.04 O +ATOM 1300 ND2 ASN A 172 10.284 33.332 -1.914 1.00 48.20 N +ATOM 1301 N PHE A 173 9.695 38.113 -4.617 1.00 41.30 N +ATOM 1302 CA PHE A 173 8.810 39.231 -4.915 1.00 42.45 C +ATOM 1303 C PHE A 173 8.895 39.652 -6.391 1.00 44.05 C +ATOM 1304 O PHE A 173 7.898 40.045 -6.998 1.00 43.32 O +ATOM 1305 CB PHE A 173 9.118 40.424 -4.012 1.00 41.78 C +ATOM 1306 CG PHE A 173 8.245 41.622 -4.272 1.00 39.79 C +ATOM 1307 CD1 PHE A 173 6.955 41.682 -3.765 1.00 39.49 C +ATOM 1308 CD2 PHE A 173 8.711 42.689 -5.021 1.00 37.99 C +ATOM 1309 CE1 PHE A 173 6.150 42.795 -4.005 1.00 38.53 C +ATOM 1310 CE2 PHE A 173 7.911 43.802 -5.262 1.00 36.13 C +ATOM 1311 CZ PHE A 173 6.631 43.850 -4.757 1.00 37.09 C +ATOM 1312 N LYS A 174 10.098 39.581 -6.955 1.00 46.01 N +ATOM 1313 CA LYS A 174 10.321 39.983 -8.344 1.00 48.08 C +ATOM 1314 C LYS A 174 9.802 38.906 -9.300 1.00 49.84 C +ATOM 1315 O LYS A 174 9.753 39.095 -10.511 1.00 50.31 O +ATOM 1316 CB LYS A 174 11.802 40.337 -8.564 1.00 47.73 C +ATOM 1317 CG LYS A 174 12.190 41.554 -7.729 1.00 46.64 C +ATOM 1318 CD LYS A 174 13.657 41.609 -7.418 1.00 45.19 C +ATOM 1319 CE LYS A 174 14.379 42.456 -8.444 1.00 45.69 C +ATOM 1320 NZ LYS A 174 15.857 42.279 -8.351 1.00 44.08 N +ATOM 1321 N LYS A 175 9.382 37.788 -8.715 1.00 52.11 N +ATOM 1322 CA LYS A 175 8.602 36.759 -9.396 1.00 54.14 C +ATOM 1323 C LYS A 175 9.423 35.473 -9.415 1.00 54.68 C +ATOM 1324 O LYS A 175 9.136 34.467 -8.751 1.00 55.07 O +ATOM 1325 CB LYS A 175 8.214 37.214 -10.809 1.00 54.60 C +ATOM 1326 CG LYS A 175 6.957 36.545 -11.369 1.00 57.59 C +ATOM 1327 CD LYS A 175 6.501 37.199 -12.700 1.00 61.87 C +ATOM 1328 CE LYS A 175 7.706 37.673 -13.531 1.00 63.51 C +ATOM 1329 NZ LYS A 175 8.861 36.709 -13.496 1.00 63.20 N +ATOM 1330 OXT LYS A 175 10.451 35.432 -10.086 1.00 55.71 O +TER 1331 LYS A 175 +HETATM 1332 K K A 176 24.990 43.276 0.005 0.50 24.45 K +HETATM 1333 NA NA A 177 1.633 34.181 11.897 1.00 26.73 NA +HETATM 1334 NA NA A 178 6.489 35.143 8.444 1.00 30.89 NA +HETATM 1335 P1 POP A 179 1.233 37.542 11.212 1.00 32.68 P +HETATM 1336 O1 POP A 179 1.910 38.831 11.612 1.00 32.62 O +HETATM 1337 O2 POP A 179 1.288 37.475 9.712 1.00 33.46 O +HETATM 1338 O3 POP A 179 1.948 36.362 11.841 1.00 30.47 O +HETATM 1339 O POP A 179 -0.339 37.641 11.573 1.00 33.48 O +HETATM 1340 P2 POP A 179 -1.193 36.552 12.370 1.00 36.05 P +HETATM 1341 O4 POP A 179 -2.611 36.792 11.954 1.00 33.39 O +HETATM 1342 O5 POP A 179 -1.079 36.873 13.870 1.00 33.69 O +HETATM 1343 O6 POP A 179 -0.735 35.128 12.124 1.00 33.11 O +HETATM 1344 O1 PG4 A 180 25.225 36.156 6.596 1.00 42.63 O +HETATM 1345 C1 PG4 A 180 25.070 35.591 5.302 1.00 44.20 C +HETATM 1346 C2 PG4 A 180 25.728 36.597 4.386 1.00 46.03 C +HETATM 1347 O2 PG4 A 180 24.774 36.857 3.380 1.00 48.37 O +HETATM 1348 C3 PG4 A 180 25.201 37.981 2.614 1.00 47.94 C +HETATM 1349 C4 PG4 A 180 25.268 39.174 3.548 1.00 46.48 C +HETATM 1350 O3 PG4 A 180 26.617 39.507 3.811 1.00 45.59 O +HETATM 1351 C5 PG4 A 180 26.819 40.888 3.597 1.00 45.33 C +HETATM 1352 C6 PG4 A 180 28.266 41.161 3.954 1.00 47.26 C +HETATM 1353 O4 PG4 A 180 28.982 41.378 2.738 1.00 48.16 O +HETATM 1354 C7 PG4 A 180 30.163 40.616 2.604 1.00 47.41 C +HETATM 1355 C8 PG4 A 180 31.331 41.437 3.117 1.00 51.14 C +HETATM 1356 O5 PG4 A 180 32.081 40.607 4.011 1.00 53.41 O +HETATM 1357 C1 PEG A 181 13.856 28.176 23.722 1.00 59.47 C +HETATM 1358 O1 PEG A 181 14.416 29.487 23.735 1.00 59.79 O +HETATM 1359 C2 PEG A 181 13.605 27.741 22.291 1.00 59.20 C +HETATM 1360 O2 PEG A 181 12.908 26.499 22.379 1.00 59.79 O +HETATM 1361 C3 PEG A 181 11.848 26.393 21.440 1.00 59.65 C +HETATM 1362 C4 PEG A 181 10.883 25.309 21.906 1.00 59.90 C +HETATM 1363 O4 PEG A 181 10.045 25.835 22.942 1.00 58.85 O +HETATM 1364 C1 PEG A 182 19.721 56.811 7.363 1.00 56.17 C +HETATM 1365 O1 PEG A 182 18.409 56.724 7.966 1.00 55.97 O +HETATM 1366 C2 PEG A 182 20.835 56.288 8.271 1.00 54.49 C +HETATM 1367 O2 PEG A 182 21.824 57.291 8.516 1.00 56.31 O +HETATM 1368 C3 PEG A 182 23.176 56.838 8.332 1.00 57.82 C +HETATM 1369 C4 PEG A 182 23.815 57.479 7.094 1.00 58.58 C +HETATM 1370 O4 PEG A 182 24.621 56.536 6.357 1.00 59.04 O +HETATM 1371 O HOH A 183 -6.268 35.297 21.123 1.00 22.39 O +HETATM 1372 O HOH A 184 18.291 50.223 3.964 1.00 24.68 O +HETATM 1373 O HOH A 185 22.029 42.728 8.623 1.00 20.47 O +HETATM 1374 O HOH A 186 15.767 55.114 9.164 1.00 20.81 O +HETATM 1375 O HOH A 187 0.754 45.724 20.847 1.00 21.83 O +HETATM 1376 O HOH A 188 11.338 47.709 21.125 1.00 19.21 O +HETATM 1377 O HOH A 189 19.695 33.152 21.711 1.00 38.29 O +HETATM 1378 O HOH A 190 10.491 50.293 22.101 1.00 18.65 O +HETATM 1379 O HOH A 191 4.344 42.176 9.606 1.00 23.68 O +HETATM 1380 O HOH A 192 22.154 49.578 16.234 1.00 24.18 O +HETATM 1381 O HOH A 193 19.540 33.045 0.367 0.50 15.02 O +HETATM 1382 O HOH A 194 -0.281 31.958 19.977 1.00 27.04 O +HETATM 1383 O HOH A 195 0.714 43.186 11.724 1.00 31.86 O +HETATM 1384 O HOH A 196 3.567 51.947 22.586 1.00 23.51 O +HETATM 1385 O HOH A 197 -1.180 48.644 17.742 1.00 15.53 O +HETATM 1386 O HOH A 198 1.948 54.836 16.377 1.00 21.93 O +HETATM 1387 O HOH A 199 2.509 44.733 28.229 1.00 21.51 O +HETATM 1388 O HOH A 200 2.391 38.378 14.597 1.00 23.11 O +HETATM 1389 O HOH A 201 1.535 33.854 14.371 1.00 27.83 O +HETATM 1390 O HOH A 202 -6.330 29.284 19.591 1.00 32.67 O +HETATM 1391 O HOH A 203 -2.980 54.585 7.752 1.00 25.04 O +HETATM 1392 O HOH A 204 -1.529 52.313 21.859 1.00 28.95 O +HETATM 1393 O HOH A 205 -4.219 37.228 18.172 1.00 29.05 O +HETATM 1394 O HOH A 206 -9.725 38.390 17.936 1.00 25.82 O +HETATM 1395 O HOH A 207 -0.251 50.231 15.527 1.00 41.88 O +HETATM 1396 O HOH A 208 -7.548 43.260 22.219 1.00 19.57 O +HETATM 1397 O HOH A 209 24.427 35.212 14.096 1.00 31.41 O +HETATM 1398 O HOH A 210 17.913 38.657 31.156 1.00 36.76 O +HETATM 1399 O HOH A 211 23.606 42.865 12.451 1.00 25.35 O +HETATM 1400 O HOH A 212 -10.993 36.660 20.173 1.00 34.07 O +HETATM 1401 O HOH A 213 12.726 35.081 31.604 1.00 41.53 O +HETATM 1402 O HOH A 214 11.555 34.813 2.535 1.00 32.40 O +HETATM 1403 O HOH A 215 26.985 45.074 13.907 1.00 33.93 O +HETATM 1404 O HOH A 216 22.305 31.774 11.176 1.00 27.99 O +HETATM 1405 O HOH A 217 -5.311 51.156 18.105 1.00 23.06 O +HETATM 1406 O HOH A 218 4.813 38.197 26.560 1.00 30.39 O +HETATM 1407 O HOH A 219 16.429 31.381 6.556 1.00 31.04 O +HETATM 1408 O HOH A 220 2.094 31.244 8.621 1.00 39.67 O +HETATM 1409 O HOH A 221 3.282 37.464 7.811 1.00 36.79 O +HETATM 1410 O HOH A 222 12.081 42.928 -4.465 1.00 35.63 O +HETATM 1411 O HOH A 223 10.457 52.853 26.328 1.00 29.83 O +HETATM 1412 O HOH A 224 -10.834 37.817 15.537 1.00 32.13 O +HETATM 1413 O HOH A 225 11.844 46.500 23.826 1.00 35.48 O +HETATM 1414 O HOH A 226 4.136 40.856 6.472 1.00 40.41 O +HETATM 1415 O HOH A 227 27.046 47.404 15.617 1.00 32.79 O +HETATM 1416 O HOH A 228 27.357 54.793 8.601 1.00 45.22 O +HETATM 1417 O HOH A 229 23.653 47.745 22.742 1.00 50.33 O +HETATM 1418 O HOH A 230 13.464 46.940 -3.502 1.00 32.04 O +HETATM 1419 O HOH A 231 3.976 32.286 14.525 1.00 31.56 O +HETATM 1420 O HOH A 232 20.596 34.827 26.319 1.00 49.91 O +HETATM 1421 O HOH A 233 0.268 53.053 17.314 1.00 42.31 O +HETATM 1422 O HOH A 234 8.635 54.732 26.919 1.00 33.52 O +HETATM 1423 O HOH A 235 8.723 45.643 25.830 1.00 31.33 O +HETATM 1424 O HOH A 236 9.525 50.219 24.646 1.00 32.19 O +HETATM 1425 O HOH A 237 29.165 40.813 21.487 1.00 56.55 O +HETATM 1426 O HOH A 238 2.494 40.055 8.917 1.00 36.15 O +HETATM 1427 O HOH A 239 -0.777 34.809 9.090 1.00 37.11 O +HETATM 1428 O HOH A 240 23.455 48.536 9.084 1.00 28.44 O +HETATM 1429 O HOH A 241 24.600 49.610 11.229 1.00 23.81 O +HETATM 1430 O HOH A 242 21.015 49.121 7.957 1.00 22.66 O +HETATM 1431 O HOH A 243 24.242 43.201 9.915 1.00 27.87 O +HETATM 1432 O HOH A 244 26.271 42.655 13.711 1.00 28.13 O +HETATM 1433 O HOH A 245 5.960 36.600 6.289 1.00 41.50 O +HETATM 1434 O HOH A 246 18.246 32.111 23.785 1.00 56.31 O +HETATM 1435 O HOH A 247 7.627 32.876 7.134 1.00 33.79 O +HETATM 1436 O HOH A 248 1.165 51.316 -0.972 1.00 46.31 O +HETATM 1437 O HOH A 249 1.154 41.748 26.990 1.00 28.03 O +HETATM 1438 O HOH A 250 5.939 26.535 21.149 1.00 44.12 O +HETATM 1439 O HOH A 251 -5.540 43.055 28.186 1.00 26.47 O +HETATM 1440 O HOH A 252 11.949 30.493 27.231 1.00 52.78 O +HETATM 1441 O HOH A 253 13.331 24.495 13.440 1.00 52.00 O +HETATM 1442 O HOH A 254 -1.435 29.723 20.052 1.00 52.22 O +HETATM 1443 O HOH A 255 2.115 43.165 6.250 1.00 34.91 O +HETATM 1444 O HOH A 256 15.992 53.085 0.933 1.00 34.04 O +HETATM 1445 O HOH A 257 2.292 33.719 9.368 1.00 44.24 O +HETATM 1446 O HOH A 258 3.626 29.350 26.403 1.00 42.97 O +HETATM 1447 O HOH A 259 -3.063 50.429 19.160 1.00 33.64 O +HETATM 1448 O HOH A 260 -4.016 34.810 12.023 1.00 43.84 O +HETATM 1449 O HOH A 261 -7.025 43.005 7.425 1.00 50.38 O +HETATM 1450 O HOH A 262 20.664 37.966 29.449 1.00 39.40 O +HETATM 1451 O HOH A 263 8.219 36.489 7.242 1.00 45.22 O +HETATM 1452 O HOH A 264 7.603 30.314 26.808 1.00 49.95 O +HETATM 1453 O HOH A 265 27.192 38.462 19.035 1.00 38.71 O +HETATM 1454 O HOH A 266 -3.725 41.084 29.707 1.00 44.44 O +HETATM 1455 O HOH A 267 -3.184 38.130 9.900 1.00 31.98 O +HETATM 1456 O HOH A 268 -6.968 37.923 11.495 1.00 40.84 O +HETATM 1457 O HOH A 269 15.958 47.852 -2.923 1.00 44.94 O +HETATM 1458 O HOH A 270 13.106 37.129 -9.048 1.00 35.12 O +HETATM 1459 O HOH A 271 23.944 34.080 16.627 1.00 56.20 O +HETATM 1460 O HOH A 272 17.584 52.420 -1.888 1.00 38.11 O +HETATM 1461 O HOH A 273 5.521 45.450 -0.564 1.00 47.04 O +HETATM 1462 O HOH A 274 25.459 49.006 4.506 1.00 54.02 O +HETATM 1463 O HOH A 275 16.595 27.943 19.928 1.00 49.01 O +HETATM 1464 O HOH A 276 22.019 36.726 26.870 1.00 56.59 O +HETATM 1465 O HOH A 277 10.474 36.654 8.412 1.00 45.47 O +HETATM 1466 O HOH A 278 24.611 33.020 11.703 1.00 47.62 O +HETATM 1467 O HOH A 279 26.899 46.740 4.551 1.00 52.92 O +HETATM 1468 O HOH A 280 6.994 29.354 29.500 1.00 59.06 O +HETATM 1469 O HOH A 281 1.016 41.471 9.152 1.00 46.63 O +HETATM 1470 O HOH A 282 -3.738 28.411 20.723 1.00 58.68 O +HETATM 1471 O HOH A 283 14.325 31.639 5.778 1.00 49.26 O +HETATM 1472 O HOH A 284 27.777 37.727 7.983 1.00 49.01 O +HETATM 1473 O HOH A 285 11.301 44.913 29.125 1.00 47.44 O +HETATM 1474 O HOH A 286 -3.722 51.289 27.893 1.00 28.88 O +HETATM 1475 O HOH A 287 5.173 46.827 -3.289 1.00 59.99 O +HETATM 1476 O HOH A 288 -9.268 38.914 11.481 1.00 39.62 O +HETATM 1477 O HOH A 289 9.346 31.934 27.060 1.00 45.27 O +HETATM 1478 O HOH A 290 24.327 46.350 8.439 1.00 39.23 O +HETATM 1479 O HOH A 291 17.766 26.234 14.240 1.00 58.80 O +HETATM 1480 O HOH A 292 14.667 53.897 27.017 1.00 44.45 O +HETATM 1481 O HOH A 293 13.540 30.919 2.872 1.00 48.68 O +HETATM 1482 O HOH A 294 13.812 54.578 29.178 1.00 37.62 O +CONECT 70 1332 +CONECT 75 1332 +CONECT 94 1332 +CONECT 535 1334 +CONECT 734 1333 +CONECT 767 1334 +CONECT 768 1333 +CONECT 772 1334 +CONECT 1332 70 75 94 +CONECT 1333 734 768 1338 1343 +CONECT 1333 1389 1445 +CONECT 1334 535 767 772 1433 +CONECT 1334 1435 1451 +CONECT 1335 1336 1337 1338 1339 +CONECT 1336 1335 +CONECT 1337 1335 +CONECT 1338 1333 1335 +CONECT 1339 1335 1340 +CONECT 1340 1339 1341 1342 1343 +CONECT 1341 1340 +CONECT 1342 1340 +CONECT 1343 1333 1340 +CONECT 1344 1345 +CONECT 1345 1344 1346 +CONECT 1346 1345 1347 +CONECT 1347 1346 1348 +CONECT 1348 1347 1349 +CONECT 1349 1348 1350 +CONECT 1350 1349 1351 +CONECT 1351 1350 1352 +CONECT 1352 1351 1353 +CONECT 1353 1352 1354 +CONECT 1354 1353 1355 +CONECT 1355 1354 1356 +CONECT 1356 1355 +CONECT 1357 1358 1359 +CONECT 1358 1357 +CONECT 1359 1357 1360 +CONECT 1360 1359 1361 +CONECT 1361 1360 1362 +CONECT 1362 1361 1363 +CONECT 1363 1362 +CONECT 1364 1365 1366 +CONECT 1365 1364 +CONECT 1366 1364 1367 +CONECT 1367 1366 1368 +CONECT 1368 1367 1369 +CONECT 1369 1368 1370 +CONECT 1370 1369 +CONECT 1389 1333 +CONECT 1433 1334 +CONECT 1435 1334 +CONECT 1445 1333 +CONECT 1451 1334 +MASTER 471 0 7 5 9 0 13 6 1481 1 54 16 +END diff --git a/pyaptamer/datasets/loader/__init__.py b/pyaptamer/datasets/loader/__init__.py index 9e23ab37..d7ee039f 100644 --- a/pyaptamer/datasets/loader/__init__.py +++ b/pyaptamer/datasets/loader/__init__.py @@ -1,5 +1,6 @@ """Loaders for different data structures.""" from pyaptamer.datasets.loader.pfoa_loader import load_pfoa_structure +from pyaptamer.datasets.loader.three_eiy_loader import load_3eiy_structure -__all__ = ["load_pfoa_structure"] +__all__ = ["load_pfoa_structure", "load_3eiy_structure"] diff --git a/pyaptamer/datasets/loader/three_eiy_loader.py b/pyaptamer/datasets/loader/three_eiy_loader.py new file mode 100644 index 00000000..a38c620c --- /dev/null +++ b/pyaptamer/datasets/loader/three_eiy_loader.py @@ -0,0 +1,25 @@ +import os + +from Bio.PDB import PDBParser + + +def load_3eiy_structure(pdb_path=None): + """ + Load the 3eiy molecule from a PDB file using Biopython. + + Parameters + ---------- + pdb_path : str, optional + Path to the PDB file. If not provided, the function uses the default path + located in the '../data/3eiy.pdb' relative to the current file. + + Returns + ------- + structure : Bio.PDB.Structure.Structure + A Biopython Structure object representing the PFOA molecule. + """ + pdb_path = os.path.join(os.path.dirname(__file__), "..", "data", "3eiy.pdb") + + parser = PDBParser(QUIET=True) + structure = parser.get_structure("3eiy", pdb_path) + return structure diff --git a/pyaptamer/datasets/tests/test_loaders.py b/pyaptamer/datasets/tests/test_loaders.py new file mode 100644 index 00000000..c466fd27 --- /dev/null +++ b/pyaptamer/datasets/tests/test_loaders.py @@ -0,0 +1,23 @@ +import pytest +from Bio.PDB.Structure import Structure + +from pyaptamer.datasets.loader import ( + load_3eiy_structure, + load_pfoa_structure, +) + +LOADERS = [ + load_pfoa_structure, + load_3eiy_structure, +] + + +@pytest.mark.parametrize("loader", LOADERS) +def test_loader_returns_structure(loader): + """ + Each loader should run without error and return a Biopython Structure. + """ + struct = loader() + assert isinstance(struct, Structure), ( + f"{loader.__name__}() did not return a Bio.PDB.Structure.Structure" + ) diff --git a/pyaptamer/datasets/tests/test_pfoa.py b/pyaptamer/datasets/tests/test_pfoa.py deleted file mode 100644 index 0ba29de1..00000000 --- a/pyaptamer/datasets/tests/test_pfoa.py +++ /dev/null @@ -1,20 +0,0 @@ -from Bio.PDB.Structure import Structure - -from pyaptamer.datasets.loader import load_pfoa_structure - - -def test_pfoa_loader(): - """ - Test that the load_pfoa_structure function runs without error and returns a valid - Structure object. - - Asserts - ------- - The datasets loads and the return value must be an instance of Biopython's - Structure class. - """ - structure = load_pfoa_structure() - - assert isinstance(structure, Structure), ( - "Returned object is not a Biopython Structure" - ) diff --git a/x.py b/x.py new file mode 100644 index 00000000..fbd07df5 --- /dev/null +++ b/x.py @@ -0,0 +1,4 @@ +from pyaptamer.datasets.loader import load_pfoa_structure +from pyaptamer.utils.struct_to_aaseq import struct_to_aaseq + +print(struct_to_aaseq(load_pfoa_structure())) From fad2f972c64fd3960afc31acbd0a0c7c978df5a9 Mon Sep 17 00:00:00 2001 From: satvshr Date: Wed, 30 Jul 2025 18:31:06 +0530 Subject: [PATCH 062/145] Added 3eiy and its loader, standardized loader tests --- x.py | 4 ---- 1 file changed, 4 deletions(-) delete mode 100644 x.py diff --git a/x.py b/x.py deleted file mode 100644 index fbd07df5..00000000 --- a/x.py +++ /dev/null @@ -1,4 +0,0 @@ -from pyaptamer.datasets.loader import load_pfoa_structure -from pyaptamer.utils.struct_to_aaseq import struct_to_aaseq - -print(struct_to_aaseq(load_pfoa_structure())) From 4a17dac45cd40eb90959d32d429b7e29d00f0833 Mon Sep 17 00:00:00 2001 From: satvshr Date: Wed, 30 Jul 2025 18:37:44 +0530 Subject: [PATCH 063/145] Adds 1ghn instead of 3eiy --- pyaptamer/datasets/data/1gnh.pdb | 17603 ++++++++++++++++ pyaptamer/datasets/data/3eiy.pdb | 2149 -- pyaptamer/datasets/loader/__init__.py | 4 +- .../loader/{three_eiy_loader.py => a.py} | 10 +- pyaptamer/datasets/tests/test_loaders.py | 4 +- x.py | 4 + 6 files changed, 17616 insertions(+), 2158 deletions(-) create mode 100644 pyaptamer/datasets/data/1gnh.pdb delete mode 100644 pyaptamer/datasets/data/3eiy.pdb rename pyaptamer/datasets/loader/{three_eiy_loader.py => a.py} (66%) create mode 100644 x.py diff --git a/pyaptamer/datasets/data/1gnh.pdb b/pyaptamer/datasets/data/1gnh.pdb new file mode 100644 index 00000000..d2990376 --- /dev/null +++ b/pyaptamer/datasets/data/1gnh.pdb @@ -0,0 +1,17603 @@ +HEADER ACUTE-PHASE PROTEIN 01-MAR-96 1GNH +TITLE HUMAN C-REACTIVE PROTEIN +COMPND MOL_ID: 1; +COMPND 2 MOLECULE: C-REACTIVE PROTEIN; +COMPND 3 CHAIN: A, B, C, D, E, F, G, H, I, J; +COMPND 4 SYNONYM: HUMAN CRP HCRP +SOURCE MOL_ID: 1; +SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; +SOURCE 3 ORGANISM_COMMON: HUMAN; +SOURCE 4 ORGANISM_TAXID: 9606 +KEYWDS PENTRAXIN, ACUTE-PHASE REACTANT, ACUTE-PHASE PROTEIN +EXPDTA X-RAY DIFFRACTION +AUTHOR A.K.SHRIVE,G.M.T.CHEETHAM,D.HOLDEN,D.A.MYLES,W.G.TURNELL, +AUTHOR 2 J.E.VOLANAKIS,M.B.PEPYS,A.C.BLOOMER,T.J.GREENHOUGH +REVDAT 3 13-NOV-24 1GNH 1 REMARK LINK +REVDAT 2 24-FEB-09 1GNH 1 VERSN +REVDAT 1 27-JAN-97 1GNH 0 +JRNL AUTH A.K.SHRIVE,G.M.CHEETHAM,D.HOLDEN,D.A.MYLES,W.G.TURNELL, +JRNL AUTH 2 J.E.VOLANAKIS,M.B.PEPYS,A.C.BLOOMER,T.J.GREENHOUGH +JRNL TITL THREE DIMENSIONAL STRUCTURE OF HUMAN C-REACTIVE PROTEIN. +JRNL REF NAT.STRUCT.BIOL. V. 3 346 1996 +JRNL REFN ISSN 1072-8368 +JRNL PMID 8599761 +JRNL DOI 10.1038/NSB0496-346 +REMARK 2 +REMARK 2 RESOLUTION. 3.00 ANGSTROMS. +REMARK 3 +REMARK 3 REFINEMENT. +REMARK 3 PROGRAM : X-PLOR 3.1 +REMARK 3 AUTHORS : BRUNGER +REMARK 3 +REMARK 3 DATA USED IN REFINEMENT. +REMARK 3 RESOLUTION RANGE HIGH (ANGSTROMS) : 3.00 +REMARK 3 RESOLUTION RANGE LOW (ANGSTROMS) : 12.00 +REMARK 3 DATA CUTOFF (SIGMA(F)) : 3.000 +REMARK 3 DATA CUTOFF HIGH (ABS(F)) : NULL +REMARK 3 DATA CUTOFF LOW (ABS(F)) : NULL +REMARK 3 COMPLETENESS (WORKING+TEST) (%) : 74.0 +REMARK 3 NUMBER OF REFLECTIONS : 39996 +REMARK 3 +REMARK 3 FIT TO DATA USED IN REFINEMENT. +REMARK 3 CROSS-VALIDATION METHOD : NULL +REMARK 3 FREE R VALUE TEST SET SELECTION : NULL +REMARK 3 R VALUE (WORKING SET) : 0.239 +REMARK 3 FREE R VALUE : 0.273 +REMARK 3 FREE R VALUE TEST SET SIZE (%) : 5.000 +REMARK 3 FREE R VALUE TEST SET COUNT : NULL +REMARK 3 ESTIMATED ERROR OF FREE R VALUE : NULL +REMARK 3 +REMARK 3 FIT IN THE HIGHEST RESOLUTION BIN. +REMARK 3 TOTAL NUMBER OF BINS USED : NULL +REMARK 3 BIN RESOLUTION RANGE HIGH (A) : NULL +REMARK 3 BIN RESOLUTION RANGE LOW (A) : NULL +REMARK 3 BIN COMPLETENESS (WORKING+TEST) (%) : NULL +REMARK 3 REFLECTIONS IN BIN (WORKING SET) : NULL +REMARK 3 BIN R VALUE (WORKING SET) : NULL +REMARK 3 BIN FREE R VALUE : NULL +REMARK 3 BIN FREE R VALUE TEST SET SIZE (%) : NULL +REMARK 3 BIN FREE R VALUE TEST SET COUNT : NULL +REMARK 3 ESTIMATED ERROR OF BIN FREE R VALUE : NULL +REMARK 3 +REMARK 3 NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT. +REMARK 3 PROTEIN ATOMS : 16320 +REMARK 3 NUCLEIC ACID ATOMS : 0 +REMARK 3 HETEROGEN ATOMS : 16 +REMARK 3 SOLVENT ATOMS : 0 +REMARK 3 +REMARK 3 B VALUES. +REMARK 3 FROM WILSON PLOT (A**2) : NULL +REMARK 3 MEAN B VALUE (OVERALL, A**2) : 25.80 +REMARK 3 OVERALL ANISOTROPIC B VALUE. +REMARK 3 B11 (A**2) : NULL +REMARK 3 B22 (A**2) : NULL +REMARK 3 B33 (A**2) : NULL +REMARK 3 B12 (A**2) : NULL +REMARK 3 B13 (A**2) : NULL +REMARK 3 B23 (A**2) : NULL +REMARK 3 +REMARK 3 ESTIMATED COORDINATE ERROR. +REMARK 3 ESD FROM LUZZATI PLOT (A) : NULL +REMARK 3 ESD FROM SIGMAA (A) : NULL +REMARK 3 LOW RESOLUTION CUTOFF (A) : NULL +REMARK 3 +REMARK 3 CROSS-VALIDATED ESTIMATED COORDINATE ERROR. +REMARK 3 ESD FROM C-V LUZZATI PLOT (A) : NULL +REMARK 3 ESD FROM C-V SIGMAA (A) : NULL +REMARK 3 +REMARK 3 RMS DEVIATIONS FROM IDEAL VALUES. +REMARK 3 BOND LENGTHS (A) : 0.010 +REMARK 3 BOND ANGLES (DEGREES) : 1.587 +REMARK 3 DIHEDRAL ANGLES (DEGREES) : NULL +REMARK 3 IMPROPER ANGLES (DEGREES) : NULL +REMARK 3 +REMARK 3 ISOTROPIC THERMAL MODEL : NULL +REMARK 3 +REMARK 3 ISOTROPIC THERMAL FACTOR RESTRAINTS. RMS SIGMA +REMARK 3 MAIN-CHAIN BOND (A**2) : NULL ; NULL +REMARK 3 MAIN-CHAIN ANGLE (A**2) : NULL ; NULL +REMARK 3 SIDE-CHAIN BOND (A**2) : NULL ; NULL +REMARK 3 SIDE-CHAIN ANGLE (A**2) : NULL ; NULL +REMARK 3 +REMARK 3 NCS MODEL : NULL +REMARK 3 +REMARK 3 NCS RESTRAINTS. RMS SIGMA/WEIGHT +REMARK 3 GROUP 1 POSITIONAL (A) : NULL ; NULL +REMARK 3 GROUP 1 B-FACTOR (A**2) : NULL ; NULL +REMARK 3 +REMARK 3 PARAMETER FILE 1 : NULL +REMARK 3 TOPOLOGY FILE 1 : NULL +REMARK 3 +REMARK 3 OTHER REFINEMENT REMARKS: +REMARK 3 RESIDUES 142 - 145 IN CHAINS D AND J ARE NOT TIED DOWN. +REMARK 3 +REMARK 3 LOOP 140-150 IN PROTOMER J (NO CALCIUM) IS LOOSELY +REMARK 3 ASSOCIATED WITH MAIN BODY OF PROTEIN. IT FORMS SYMMETRY +REMARK 3 CONTACT TO PROTOMER I WITH GLU 147 J CHELATING TO +REMARK 3 CALCIUM IONS IN PROTOMER I. +REMARK 3 +REMARK 3 LOOP 140-150 IN PROTOMER D (NO CALCIUM) IS LOOSELY +REMARK 3 ASSOCIATED WITH MAIN BODY OF PROTEIN. IT FORMS SYMMETRY +REMARK 3 CONTACT TO PROTOMER C WITH GLU 147 D CHELATING TO +REMARK 3 CALCIUM IONS IN PROTOMER C. +REMARK 3 +REMARK 3 THE UNCERTAINTY IN RESIDUES 142 - 145 IN CHAINS D AND J +REMARK 3 RESULTS IN 2.4 A CLOSE NON-BONDED CONTACTS D 142 - D 143 +REMARK 3 AND J 142 - J 143. +REMARK 3 +REMARK 3 RESIDUE LEU 43 IN CHAINS D AND J FALLS IN A +REMARK 3 GENEROUSLY ALLOWED POSITION ON THE RAMACHANDRAN PLOT. +REMARK 3 THIS MINOR UNCERTAINTY IN THIS REGION IN PROTOMERS +REMARK 3 D AND J RESULTS IN TWO 2.6 A NON-BONDED CONTACTS IN EACH +REMARK 3 PROTOMER (D 42 - D 43, D 44 - D 45 , J 42 - J 43, +REMARK 3 J 44 - J 45). +REMARK 4 +REMARK 4 1GNH COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 +REMARK 100 +REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY BNL. +REMARK 100 THE DEPOSITION ID IS D_1000173633. +REMARK 200 +REMARK 200 EXPERIMENTAL DETAILS +REMARK 200 EXPERIMENT TYPE : X-RAY DIFFRACTION +REMARK 200 DATE OF DATA COLLECTION : MAR-88 +REMARK 200 TEMPERATURE (KELVIN) : NULL +REMARK 200 PH : NULL +REMARK 200 NUMBER OF CRYSTALS USED : NULL +REMARK 200 +REMARK 200 SYNCHROTRON (Y/N) : Y +REMARK 200 RADIATION SOURCE : SRS +REMARK 200 BEAMLINE : PX9.6 +REMARK 200 X-RAY GENERATOR MODEL : NULL +REMARK 200 MONOCHROMATIC OR LAUE (M/L) : M +REMARK 200 WAVELENGTH OR RANGE (A) : 0.901 +REMARK 200 MONOCHROMATOR : NULL +REMARK 200 OPTICS : NULL +REMARK 200 +REMARK 200 DETECTOR TYPE : FILM +REMARK 200 DETECTOR MANUFACTURER : FILM +REMARK 200 INTENSITY-INTEGRATION SOFTWARE : DENZO, CCP4 +REMARK 200 DATA SCALING SOFTWARE : NULL +REMARK 200 +REMARK 200 NUMBER OF UNIQUE REFLECTIONS : 57243 +REMARK 200 RESOLUTION RANGE HIGH (A) : 3.000 +REMARK 200 RESOLUTION RANGE LOW (A) : 20.000 +REMARK 200 REJECTION CRITERIA (SIGMA(I)) : 0.000 +REMARK 200 +REMARK 200 OVERALL. +REMARK 200 COMPLETENESS FOR RANGE (%) : 74.0 +REMARK 200 DATA REDUNDANCY : 1.500 +REMARK 200 R MERGE (I) : 0.13800 +REMARK 200 R SYM (I) : NULL +REMARK 200 FOR THE DATA SET : NULL +REMARK 200 +REMARK 200 IN THE HIGHEST RESOLUTION SHELL. +REMARK 200 HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : NULL +REMARK 200 HIGHEST RESOLUTION SHELL, RANGE LOW (A) : NULL +REMARK 200 COMPLETENESS FOR SHELL (%) : NULL +REMARK 200 DATA REDUNDANCY IN SHELL : NULL +REMARK 200 R MERGE FOR SHELL (I) : NULL +REMARK 200 R SYM FOR SHELL (I) : NULL +REMARK 200 FOR SHELL : NULL +REMARK 200 +REMARK 200 DIFFRACTION PROTOCOL: NULL +REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: NULL +REMARK 200 SOFTWARE USED: X-PLOR 3.1 +REMARK 200 STARTING MODEL: NULL +REMARK 200 +REMARK 200 REMARK: NULL +REMARK 280 +REMARK 280 CRYSTAL +REMARK 280 SOLVENT CONTENT, VS (%): 65.00 +REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 4.10 +REMARK 280 +REMARK 280 CRYSTALLIZATION CONDITIONS: NULL +REMARK 290 +REMARK 290 CRYSTALLOGRAPHIC SYMMETRY +REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 21 21 21 +REMARK 290 +REMARK 290 SYMOP SYMMETRY +REMARK 290 NNNMMM OPERATOR +REMARK 290 1555 X,Y,Z +REMARK 290 2555 -X+1/2,-Y,Z+1/2 +REMARK 290 3555 -X,Y+1/2,-Z+1/2 +REMARK 290 4555 X+1/2,-Y+1/2,-Z +REMARK 290 +REMARK 290 WHERE NNN -> OPERATOR NUMBER +REMARK 290 MMM -> TRANSLATION VECTOR +REMARK 290 +REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS +REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM +REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY +REMARK 290 RELATED MOLECULES. +REMARK 290 SMTRY1 1 1.000000 0.000000 0.000000 0.00000 +REMARK 290 SMTRY2 1 0.000000 1.000000 0.000000 0.00000 +REMARK 290 SMTRY3 1 0.000000 0.000000 1.000000 0.00000 +REMARK 290 SMTRY1 2 -1.000000 0.000000 0.000000 50.53000 +REMARK 290 SMTRY2 2 0.000000 -1.000000 0.000000 0.00000 +REMARK 290 SMTRY3 2 0.000000 0.000000 1.000000 121.46500 +REMARK 290 SMTRY1 3 -1.000000 0.000000 0.000000 0.00000 +REMARK 290 SMTRY2 3 0.000000 1.000000 0.000000 77.12500 +REMARK 290 SMTRY3 3 0.000000 0.000000 -1.000000 121.46500 +REMARK 290 SMTRY1 4 1.000000 0.000000 0.000000 50.53000 +REMARK 290 SMTRY2 4 0.000000 -1.000000 0.000000 77.12500 +REMARK 290 SMTRY3 4 0.000000 0.000000 -1.000000 0.00000 +REMARK 290 +REMARK 290 REMARK: NULL +REMARK 300 +REMARK 300 BIOMOLECULE: 1, 2 +REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM +REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN +REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON +REMARK 300 BURIED SURFACE AREA. +REMARK 350 +REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN +REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE +REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS +REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND +REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. +REMARK 350 +REMARK 350 BIOMOLECULE: 1 +REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: PENTAMERIC +REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E +REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 +REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 +REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 +REMARK 350 +REMARK 350 BIOMOLECULE: 2 +REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: PENTAMERIC +REMARK 350 APPLY THE FOLLOWING TO CHAINS: F, G, H, I, J +REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 +REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 +REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 +REMARK 400 +REMARK 400 COMPOUND +REMARK 400 THE SIDE CHAIN OF ASN 61 IN PROTOMERS C AND I (THE +REMARK 400 PROTOMERS WHERE THE 140 - 150 LOOP FROM D, J, RESPECTIVELY, +REMARK 400 CHELATES TO THE CALCIUM IONS) APPEARS TO ADOPT A DIFFERENT +REMARK 400 ROTAMER (CHI2+180) THAN THAT IN THE OTHER 6 CALCIUM BOUND +REMARK 400 PROTOMERS. THE SIDE CHAIN OF GLU 147 ALSO ADOPTS +REMARK 400 DIFFERENT, BUT CONSISTENT, CONFORMATIONS IN THE VARIOUS +REMARK 400 CALCIUM BOUND PROTOMERS DEPENDING ON CRYSTAL CONTACTS. +REMARK 500 +REMARK 500 GEOMETRY AND STEREOCHEMISTRY +REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT +REMARK 500 +REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT. +REMARK 500 +REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE +REMARK 500 O PRO I 202 NH2 ARG J 118 2.18 +REMARK 500 +REMARK 500 REMARK: NULL +REMARK 500 +REMARK 500 GEOMETRY AND STEREOCHEMISTRY +REMARK 500 SUBTOPIC: CLOSE CONTACTS +REMARK 500 +REMARK 500 THE FOLLOWING ATOMS THAT ARE RELATED BY CRYSTALLOGRAPHIC +REMARK 500 SYMMETRY ARE IN CLOSE CONTACT. AN ATOM LOCATED WITHIN 0.15 +REMARK 500 ANGSTROMS OF A SYMMETRY RELATED ATOM IS ASSUMED TO BE ON A +REMARK 500 SPECIAL POSITION AND IS, THEREFORE, LISTED IN REMARK 375 +REMARK 500 INSTEAD OF REMARK 500. ATOMS WITH NON-BLANK ALTERNATE +REMARK 500 LOCATION INDICATORS ARE NOT INCLUDED IN THE CALCULATIONS. +REMARK 500 +REMARK 500 DISTANCE CUTOFF: +REMARK 500 2.2 ANGSTROMS FOR CONTACTS NOT INVOLVING HYDROGEN ATOMS +REMARK 500 1.6 ANGSTROMS FOR CONTACTS INVOLVING HYDROGEN ATOMS +REMARK 500 +REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI SSYMOP DISTANCE +REMARK 500 O GLY D 177 O PRO J 182 2564 2.13 +REMARK 500 O PRO E 182 O GLY I 177 2564 2.18 +REMARK 500 +REMARK 500 REMARK: NULL +REMARK 500 +REMARK 500 GEOMETRY AND STEREOCHEMISTRY +REMARK 500 SUBTOPIC: TORSION ANGLES +REMARK 500 +REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: +REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; +REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). +REMARK 500 +REMARK 500 STANDARD TABLE: +REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) +REMARK 500 +REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- +REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 +REMARK 500 +REMARK 500 M RES CSSEQI PSI PHI +REMARK 500 SER A 44 -36.95 -30.78 +REMARK 500 ASN A 61 64.05 -117.27 +REMARK 500 LYS A 69 133.80 -37.10 +REMARK 500 ILE A 71 -64.33 -120.72 +REMARK 500 PHE A 142 101.65 -49.92 +REMARK 500 VAL A 184 -65.24 -139.32 +REMARK 500 ALA A 189 57.23 -140.72 +REMARK 500 SER B 44 -37.39 -29.73 +REMARK 500 ASN B 61 63.86 -117.83 +REMARK 500 LYS B 69 134.74 -36.10 +REMARK 500 ILE B 71 -64.45 -120.69 +REMARK 500 PHE B 142 101.62 -50.23 +REMARK 500 VAL B 184 -66.03 -138.80 +REMARK 500 ALA B 189 56.95 -141.16 +REMARK 500 SER C 44 -38.07 -30.10 +REMARK 500 ASN C 61 63.62 -117.36 +REMARK 500 LYS C 69 133.70 -35.98 +REMARK 500 ILE C 71 -64.58 -121.20 +REMARK 500 PHE C 142 101.92 -50.49 +REMARK 500 VAL C 184 -64.97 -139.24 +REMARK 500 ALA C 189 57.39 -140.15 +REMARK 500 GLU D 42 77.08 -101.22 +REMARK 500 LEU D 43 88.61 -26.05 +REMARK 500 SER D 44 -138.08 -101.48 +REMARK 500 SER D 45 174.19 -48.54 +REMARK 500 ASN D 61 64.57 -117.00 +REMARK 500 ASP D 70 36.32 -87.00 +REMARK 500 ILE D 71 -52.52 -142.31 +REMARK 500 PRO D 87 -86.33 -54.50 +REMARK 500 GLN D 137 146.33 -172.69 +REMARK 500 SER D 141 -85.38 -17.95 +REMARK 500 PHE D 142 25.14 -63.91 +REMARK 500 GLN D 150 108.43 65.37 +REMARK 500 VAL D 184 -64.45 -141.33 +REMARK 500 ALA D 189 56.18 -140.96 +REMARK 500 SER E 44 -38.54 -30.75 +REMARK 500 ASN E 61 64.16 -117.90 +REMARK 500 LYS E 69 134.38 -37.41 +REMARK 500 PHE E 142 101.31 -50.32 +REMARK 500 VAL E 184 -64.73 -139.25 +REMARK 500 ALA E 189 57.53 -140.65 +REMARK 500 SER F 44 -37.58 -28.84 +REMARK 500 ASN F 61 63.70 -117.44 +REMARK 500 LYS F 69 133.62 -37.06 +REMARK 500 PHE F 142 102.37 -51.22 +REMARK 500 VAL F 184 -65.62 -139.70 +REMARK 500 ALA F 189 58.35 -140.34 +REMARK 500 SER G 44 -37.43 -29.75 +REMARK 500 ASN G 61 64.44 -117.33 +REMARK 500 LYS G 69 133.54 -35.93 +REMARK 500 +REMARK 500 THIS ENTRY HAS 80 RAMACHANDRAN OUTLIERS. +REMARK 500 +REMARK 500 REMARK: NULL +REMARK 500 +REMARK 500 GEOMETRY AND STEREOCHEMISTRY +REMARK 500 SUBTOPIC: MAIN CHAIN PLANARITY +REMARK 500 +REMARK 500 THE FOLLOWING RESIDUES HAVE A PSEUDO PLANARITY +REMARK 500 TORSION ANGLE, C(I) - CA(I) - N(I+1) - O(I), GREATER +REMARK 500 10.0 DEGREES. (M=MODEL NUMBER; RES=RESIDUE NAME; +REMARK 500 C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; +REMARK 500 I=INSERTION CODE). +REMARK 500 +REMARK 500 M RES CSSEQI ANGLE +REMARK 500 GLU D 42 -15.37 +REMARK 500 GLU J 42 -15.34 +REMARK 500 +REMARK 500 REMARK: NULL +REMARK 600 +REMARK 600 HETEROGEN +REMARK 600 +REMARK 600 THE SECOND CALCIUM ION (502) IN PROTOMERS A AND B HAS A +REMARK 600 VERY LOW OCCUPANCY AND DOES NOT REFINE WELL. THUS A 502 +REMARK 600 AND B 502 HAVE BEEN PLACED, FOLLOWING FULL STRUCTURAL +REMARK 600 REFINEMENT, ACCORDING TO THE ELECTRON DENSITY PRESENT IN +REMARK 600 2FO-FC MAPS. +REMARK 620 +REMARK 620 METAL COORDINATION +REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; +REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE): +REMARK 620 +REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL +REMARK 620 CA A 501 CA +REMARK 620 N RES CSSEQI ATOM +REMARK 620 1 ASP A 60 OD2 +REMARK 620 2 ASN A 61 OD1 69.9 +REMARK 620 3 ASN A 61 ND2 70.0 43.9 +REMARK 620 4 GLU A 138 OE1 161.1 128.1 117.4 +REMARK 620 5 GLU A 138 OE2 127.8 103.2 71.3 48.8 +REMARK 620 6 GLN A 139 O 77.6 111.7 69.1 88.8 56.5 +REMARK 620 7 ASP A 140 OD1 87.4 148.6 146.8 77.8 107.9 82.8 +REMARK 620 N 1 2 3 4 5 6 +REMARK 620 +REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL +REMARK 620 CA A 502 CA +REMARK 620 N RES CSSEQI ATOM +REMARK 620 1 GLU A 138 OE1 +REMARK 620 2 ASP A 140 OD2 82.9 +REMARK 620 3 ASP A 140 OD1 51.7 40.4 +REMARK 620 4 GLN A 150 OE1 82.3 150.1 133.9 +REMARK 620 N 1 2 3 +REMARK 620 +REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL +REMARK 620 CA B 501 CA +REMARK 620 N RES CSSEQI ATOM +REMARK 620 1 ASN B 61 OD1 +REMARK 620 2 ASN B 61 ND2 42.3 +REMARK 620 3 GLU B 138 CD 144.2 107.0 +REMARK 620 4 GLU B 138 OE1 176.7 137.8 34.0 +REMARK 620 5 GLU B 138 OE2 115.5 75.2 32.2 63.7 +REMARK 620 6 GLN B 139 O 95.1 59.5 74.0 86.7 52.0 +REMARK 620 7 ASP B 140 OD1 108.1 106.7 97.5 75.1 102.5 63.7 +REMARK 620 N 1 2 3 4 5 6 +REMARK 620 +REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL +REMARK 620 CA B 502 CA +REMARK 620 N RES CSSEQI ATOM +REMARK 620 1 GLU B 138 OE1 +REMARK 620 2 ASP B 140 OD2 102.4 +REMARK 620 3 ASP B 140 OD1 61.7 46.4 +REMARK 620 4 GLN B 150 OE1 83.4 170.9 141.9 +REMARK 620 N 1 2 3 +REMARK 620 +REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL +REMARK 620 CA C 501 CA +REMARK 620 N RES CSSEQI ATOM +REMARK 620 1 ASP C 60 OD2 +REMARK 620 2 ASN C 61 ND2 68.8 +REMARK 620 3 ASN C 61 OD1 71.6 45.1 +REMARK 620 4 GLU C 138 OE1 157.0 129.4 130.5 +REMARK 620 5 GLU C 138 OE2 138.0 113.1 81.8 54.2 +REMARK 620 6 GLN C 139 O 80.1 122.0 79.4 96.6 63.2 +REMARK 620 7 ASP C 140 OD1 83.4 133.1 153.3 73.7 112.8 87.4 +REMARK 620 8 GLU D 147 OE1 96.8 46.7 88.5 90.7 114.7 167.9 103.9 +REMARK 620 N 1 2 3 4 5 6 7 +REMARK 620 +REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL +REMARK 620 CA C 502 CA +REMARK 620 N RES CSSEQI ATOM +REMARK 620 1 GLU C 138 OE1 +REMARK 620 2 ASP C 140 OD2 105.3 +REMARK 620 3 ASP C 140 OD1 62.2 49.7 +REMARK 620 4 GLU C 147 OE1 159.6 90.4 124.1 +REMARK 620 5 GLN C 150 OE1 88.8 161.8 148.1 79.0 +REMARK 620 N 1 2 3 4 +REMARK 620 +REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL +REMARK 620 CA E 501 CA +REMARK 620 N RES CSSEQI ATOM +REMARK 620 1 ASP E 60 OD2 +REMARK 620 2 ASN E 61 OD1 79.7 +REMARK 620 3 ASN E 61 ND2 81.4 47.5 +REMARK 620 4 GLU E 138 OE1 163.3 117.0 109.2 +REMARK 620 5 GLU E 138 OE2 137.1 100.8 69.4 43.7 +REMARK 620 6 GLN E 139 O 90.0 121.7 74.2 80.8 52.8 +REMARK 620 7 ASP E 140 OD1 101.1 154.6 157.8 64.1 95.6 83.7 +REMARK 620 N 1 2 3 4 5 6 +REMARK 620 +REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL +REMARK 620 CA E 502 CA +REMARK 620 N RES CSSEQI ATOM +REMARK 620 1 GLU E 138 OE1 +REMARK 620 2 ASP E 140 OD2 96.1 +REMARK 620 3 ASP E 140 OD1 60.8 47.8 +REMARK 620 4 GLN E 150 OE1 91.0 143.7 151.7 +REMARK 620 N 1 2 3 +REMARK 620 +REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL +REMARK 620 CA F 501 CA +REMARK 620 N RES CSSEQI ATOM +REMARK 620 1 ASN F 61 OD1 +REMARK 620 2 GLU F 138 OE1 146.3 +REMARK 620 3 GLU F 138 OE2 99.6 47.2 +REMARK 620 4 ASP F 140 OD1 118.8 72.2 87.7 +REMARK 620 N 1 2 3 +REMARK 620 +REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL +REMARK 620 CA F 502 CA +REMARK 620 N RES CSSEQI ATOM +REMARK 620 1 GLU F 138 OE1 +REMARK 620 2 ASP F 140 OD2 101.6 +REMARK 620 3 ASP F 140 OD1 60.4 46.7 +REMARK 620 4 GLU F 147 OE1 147.7 104.2 130.3 +REMARK 620 5 GLU F 147 OE2 143.8 66.2 91.1 41.2 +REMARK 620 6 GLN F 150 OE1 92.0 165.1 148.2 65.4 105.9 +REMARK 620 N 1 2 3 4 5 +REMARK 620 +REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL +REMARK 620 CA G 501 CA +REMARK 620 N RES CSSEQI ATOM +REMARK 620 1 ASP G 60 OD2 +REMARK 620 2 ASN G 61 OD1 78.1 +REMARK 620 3 ASN G 61 ND2 76.4 52.0 +REMARK 620 4 GLU G 138 OE1 145.2 136.2 117.5 +REMARK 620 5 GLU G 138 OE2 126.1 113.8 73.6 45.1 +REMARK 620 6 GLN G 139 O 76.9 120.7 70.2 78.6 51.1 +REMARK 620 7 ASP G 140 OD1 84.6 155.1 140.1 64.3 90.9 71.6 +REMARK 620 N 1 2 3 4 5 6 +REMARK 620 +REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL +REMARK 620 CA G 502 CA +REMARK 620 N RES CSSEQI ATOM +REMARK 620 1 GLU G 138 OE1 +REMARK 620 2 ASP G 140 OD1 63.2 +REMARK 620 3 ASP G 140 OD2 76.8 44.5 +REMARK 620 4 GLN G 150 OE1 73.1 125.3 96.2 +REMARK 620 N 1 2 3 +REMARK 620 +REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL +REMARK 620 CA H 501 CA +REMARK 620 N RES CSSEQI ATOM +REMARK 620 1 ASP H 60 OD2 +REMARK 620 2 ASN H 61 OD1 71.3 +REMARK 620 3 ASN H 61 ND2 70.4 45.8 +REMARK 620 4 GLU H 138 OE1 154.6 131.8 115.9 +REMARK 620 5 GLU H 138 OE2 123.7 104.8 69.6 48.2 +REMARK 620 6 GLN H 139 O 75.3 110.4 66.1 84.9 52.9 +REMARK 620 7 ASP H 140 OD1 85.3 151.1 140.7 75.1 102.2 78.3 +REMARK 620 N 1 2 3 4 5 6 +REMARK 620 +REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL +REMARK 620 CA H 502 CA +REMARK 620 N RES CSSEQI ATOM +REMARK 620 1 GLU H 138 OE1 +REMARK 620 2 ASP H 140 OD2 109.0 +REMARK 620 3 ASP H 140 OD1 65.6 52.7 +REMARK 620 4 GLU H 147 OE2 158.4 76.8 106.3 +REMARK 620 5 GLN H 150 OE1 82.2 157.8 146.1 99.9 +REMARK 620 N 1 2 3 4 +REMARK 620 +REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL +REMARK 620 CA I 501 CA +REMARK 620 N RES CSSEQI ATOM +REMARK 620 1 ASP I 60 OD2 +REMARK 620 2 ASN I 61 OD1 87.7 +REMARK 620 3 ASN I 61 ND2 81.2 48.6 +REMARK 620 4 GLU I 138 OE2 149.8 76.0 105.1 +REMARK 620 5 GLU I 138 OE1 159.1 112.9 114.4 42.9 +REMARK 620 6 GLN I 139 O 97.3 86.3 134.9 57.0 81.6 +REMARK 620 7 ASP I 140 OD1 100.0 169.7 139.0 94.1 59.2 85.9 +REMARK 620 8 GLU J 147 OE1 119.3 115.9 77.4 90.8 55.7 136.4 66.3 +REMARK 620 N 1 2 3 4 5 6 7 +REMARK 620 +REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL +REMARK 620 CA I 502 CA +REMARK 620 N RES CSSEQI ATOM +REMARK 620 1 GLU I 138 OE1 +REMARK 620 2 ASP I 140 OD2 102.6 +REMARK 620 3 ASP I 140 OD1 60.7 50.8 +REMARK 620 4 GLU I 147 OE1 166.0 89.6 125.7 +REMARK 620 5 GLN I 150 OE1 79.7 160.1 139.4 91.1 +REMARK 620 6 GLU J 147 OE2 87.4 97.8 69.4 84.2 102.1 +REMARK 620 N 1 2 3 4 5 +REMARK 800 +REMARK 800 SITE +REMARK 800 SITE_IDENTIFIER: AC1 +REMARK 800 EVIDENCE_CODE: SOFTWARE +REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CA A 501 +REMARK 800 +REMARK 800 SITE_IDENTIFIER: AC2 +REMARK 800 EVIDENCE_CODE: SOFTWARE +REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CA A 502 +REMARK 800 +REMARK 800 SITE_IDENTIFIER: AC3 +REMARK 800 EVIDENCE_CODE: SOFTWARE +REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CA B 501 +REMARK 800 +REMARK 800 SITE_IDENTIFIER: AC4 +REMARK 800 EVIDENCE_CODE: SOFTWARE +REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CA B 502 +REMARK 800 +REMARK 800 SITE_IDENTIFIER: AC5 +REMARK 800 EVIDENCE_CODE: SOFTWARE +REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CA C 501 +REMARK 800 +REMARK 800 SITE_IDENTIFIER: AC6 +REMARK 800 EVIDENCE_CODE: SOFTWARE +REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CA C 502 +REMARK 800 +REMARK 800 SITE_IDENTIFIER: AC7 +REMARK 800 EVIDENCE_CODE: SOFTWARE +REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CA E 501 +REMARK 800 +REMARK 800 SITE_IDENTIFIER: AC8 +REMARK 800 EVIDENCE_CODE: SOFTWARE +REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CA E 502 +REMARK 800 +REMARK 800 SITE_IDENTIFIER: AC9 +REMARK 800 EVIDENCE_CODE: SOFTWARE +REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CA F 501 +REMARK 800 +REMARK 800 SITE_IDENTIFIER: BC1 +REMARK 800 EVIDENCE_CODE: SOFTWARE +REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CA F 502 +REMARK 800 +REMARK 800 SITE_IDENTIFIER: BC2 +REMARK 800 EVIDENCE_CODE: SOFTWARE +REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CA G 501 +REMARK 800 +REMARK 800 SITE_IDENTIFIER: BC3 +REMARK 800 EVIDENCE_CODE: SOFTWARE +REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CA G 502 +REMARK 800 +REMARK 800 SITE_IDENTIFIER: BC4 +REMARK 800 EVIDENCE_CODE: SOFTWARE +REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CA H 501 +REMARK 800 +REMARK 800 SITE_IDENTIFIER: BC5 +REMARK 800 EVIDENCE_CODE: SOFTWARE +REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CA H 502 +REMARK 800 +REMARK 800 SITE_IDENTIFIER: BC6 +REMARK 800 EVIDENCE_CODE: SOFTWARE +REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CA I 501 +REMARK 800 +REMARK 800 SITE_IDENTIFIER: BC7 +REMARK 800 EVIDENCE_CODE: SOFTWARE +REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CA I 502 +DBREF 1GNH A 1 206 UNP P02741 CRP_HUMAN 19 224 +DBREF 1GNH B 1 206 UNP P02741 CRP_HUMAN 19 224 +DBREF 1GNH C 1 206 UNP P02741 CRP_HUMAN 19 224 +DBREF 1GNH D 1 206 UNP P02741 CRP_HUMAN 19 224 +DBREF 1GNH E 1 206 UNP P02741 CRP_HUMAN 19 224 +DBREF 1GNH F 1 206 UNP P02741 CRP_HUMAN 19 224 +DBREF 1GNH G 1 206 UNP P02741 CRP_HUMAN 19 224 +DBREF 1GNH H 1 206 UNP P02741 CRP_HUMAN 19 224 +DBREF 1GNH I 1 206 UNP P02741 CRP_HUMAN 19 224 +DBREF 1GNH J 1 206 UNP P02741 CRP_HUMAN 19 224 +SEQRES 1 A 206 GLN THR ASP MET SER ARG LYS ALA PHE VAL PHE PRO LYS +SEQRES 2 A 206 GLU SER ASP THR SER TYR VAL SER LEU LYS ALA PRO LEU +SEQRES 3 A 206 THR LYS PRO LEU LYS ALA PHE THR VAL CYS LEU HIS PHE +SEQRES 4 A 206 TYR THR GLU LEU SER SER THR ARG GLY TYR SER ILE PHE +SEQRES 5 A 206 SER TYR ALA THR LYS ARG GLN ASP ASN GLU ILE LEU ILE +SEQRES 6 A 206 PHE TRP SER LYS ASP ILE GLY TYR SER PHE THR VAL GLY +SEQRES 7 A 206 GLY SER GLU ILE LEU PHE GLU VAL PRO GLU VAL THR VAL +SEQRES 8 A 206 ALA PRO VAL HIS ILE CYS THR SER TRP GLU SER ALA SER +SEQRES 9 A 206 GLY ILE VAL GLU PHE TRP VAL ASP GLY LYS PRO ARG VAL +SEQRES 10 A 206 ARG LYS SER LEU LYS LYS GLY TYR THR VAL GLY ALA GLU +SEQRES 11 A 206 ALA SER ILE ILE LEU GLY GLN GLU GLN ASP SER PHE GLY +SEQRES 12 A 206 GLY ASN PHE GLU GLY SER GLN SER LEU VAL GLY ASP ILE +SEQRES 13 A 206 GLY ASN VAL ASN MET TRP ASP PHE VAL LEU SER PRO ASP +SEQRES 14 A 206 GLU ILE ASN THR ILE TYR LEU GLY GLY PRO PHE SER PRO +SEQRES 15 A 206 ASN VAL LEU ASN TRP ARG ALA LEU LYS TYR GLU VAL GLN +SEQRES 16 A 206 GLY GLU VAL PHE THR LYS PRO GLN LEU TRP PRO +SEQRES 1 B 206 GLN THR ASP MET SER ARG LYS ALA PHE VAL PHE PRO LYS +SEQRES 2 B 206 GLU SER ASP THR SER TYR VAL SER LEU LYS ALA PRO LEU +SEQRES 3 B 206 THR LYS PRO LEU LYS ALA PHE THR VAL CYS LEU HIS PHE +SEQRES 4 B 206 TYR THR GLU LEU SER SER THR ARG GLY TYR SER ILE PHE +SEQRES 5 B 206 SER TYR ALA THR LYS ARG GLN ASP ASN GLU ILE LEU ILE +SEQRES 6 B 206 PHE TRP SER LYS ASP ILE GLY TYR SER PHE THR VAL GLY +SEQRES 7 B 206 GLY SER GLU ILE LEU PHE GLU VAL PRO GLU VAL THR VAL +SEQRES 8 B 206 ALA PRO VAL HIS ILE CYS THR SER TRP GLU SER ALA SER +SEQRES 9 B 206 GLY ILE VAL GLU PHE TRP VAL ASP GLY LYS PRO ARG VAL +SEQRES 10 B 206 ARG LYS SER LEU LYS LYS GLY TYR THR VAL GLY ALA GLU +SEQRES 11 B 206 ALA SER ILE ILE LEU GLY GLN GLU GLN ASP SER PHE GLY +SEQRES 12 B 206 GLY ASN PHE GLU GLY SER GLN SER LEU VAL GLY ASP ILE +SEQRES 13 B 206 GLY ASN VAL ASN MET TRP ASP PHE VAL LEU SER PRO ASP +SEQRES 14 B 206 GLU ILE ASN THR ILE TYR LEU GLY GLY PRO PHE SER PRO +SEQRES 15 B 206 ASN VAL LEU ASN TRP ARG ALA LEU LYS TYR GLU VAL GLN +SEQRES 16 B 206 GLY GLU VAL PHE THR LYS PRO GLN LEU TRP PRO +SEQRES 1 C 206 GLN THR ASP MET SER ARG LYS ALA PHE VAL PHE PRO LYS +SEQRES 2 C 206 GLU SER ASP THR SER TYR VAL SER LEU LYS ALA PRO LEU +SEQRES 3 C 206 THR LYS PRO LEU LYS ALA PHE THR VAL CYS LEU HIS PHE +SEQRES 4 C 206 TYR THR GLU LEU SER SER THR ARG GLY TYR SER ILE PHE +SEQRES 5 C 206 SER TYR ALA THR LYS ARG GLN ASP ASN GLU ILE LEU ILE +SEQRES 6 C 206 PHE TRP SER LYS ASP ILE GLY TYR SER PHE THR VAL GLY +SEQRES 7 C 206 GLY SER GLU ILE LEU PHE GLU VAL PRO GLU VAL THR VAL +SEQRES 8 C 206 ALA PRO VAL HIS ILE CYS THR SER TRP GLU SER ALA SER +SEQRES 9 C 206 GLY ILE VAL GLU PHE TRP VAL ASP GLY LYS PRO ARG VAL +SEQRES 10 C 206 ARG LYS SER LEU LYS LYS GLY TYR THR VAL GLY ALA GLU +SEQRES 11 C 206 ALA SER ILE ILE LEU GLY GLN GLU GLN ASP SER PHE GLY +SEQRES 12 C 206 GLY ASN PHE GLU GLY SER GLN SER LEU VAL GLY ASP ILE +SEQRES 13 C 206 GLY ASN VAL ASN MET TRP ASP PHE VAL LEU SER PRO ASP +SEQRES 14 C 206 GLU ILE ASN THR ILE TYR LEU GLY GLY PRO PHE SER PRO +SEQRES 15 C 206 ASN VAL LEU ASN TRP ARG ALA LEU LYS TYR GLU VAL GLN +SEQRES 16 C 206 GLY GLU VAL PHE THR LYS PRO GLN LEU TRP PRO +SEQRES 1 D 206 GLN THR ASP MET SER ARG LYS ALA PHE VAL PHE PRO LYS +SEQRES 2 D 206 GLU SER ASP THR SER TYR VAL SER LEU LYS ALA PRO LEU +SEQRES 3 D 206 THR LYS PRO LEU LYS ALA PHE THR VAL CYS LEU HIS PHE +SEQRES 4 D 206 TYR THR GLU LEU SER SER THR ARG GLY TYR SER ILE PHE +SEQRES 5 D 206 SER TYR ALA THR LYS ARG GLN ASP ASN GLU ILE LEU ILE +SEQRES 6 D 206 PHE TRP SER LYS ASP ILE GLY TYR SER PHE THR VAL GLY +SEQRES 7 D 206 GLY SER GLU ILE LEU PHE GLU VAL PRO GLU VAL THR VAL +SEQRES 8 D 206 ALA PRO VAL HIS ILE CYS THR SER TRP GLU SER ALA SER +SEQRES 9 D 206 GLY ILE VAL GLU PHE TRP VAL ASP GLY LYS PRO ARG VAL +SEQRES 10 D 206 ARG LYS SER LEU LYS LYS GLY TYR THR VAL GLY ALA GLU +SEQRES 11 D 206 ALA SER ILE ILE LEU GLY GLN GLU GLN ASP SER PHE GLY +SEQRES 12 D 206 GLY ASN PHE GLU GLY SER GLN SER LEU VAL GLY ASP ILE +SEQRES 13 D 206 GLY ASN VAL ASN MET TRP ASP PHE VAL LEU SER PRO ASP +SEQRES 14 D 206 GLU ILE ASN THR ILE TYR LEU GLY GLY PRO PHE SER PRO +SEQRES 15 D 206 ASN VAL LEU ASN TRP ARG ALA LEU LYS TYR GLU VAL GLN +SEQRES 16 D 206 GLY GLU VAL PHE THR LYS PRO GLN LEU TRP PRO +SEQRES 1 E 206 GLN THR ASP MET SER ARG LYS ALA PHE VAL PHE PRO LYS +SEQRES 2 E 206 GLU SER ASP THR SER TYR VAL SER LEU LYS ALA PRO LEU +SEQRES 3 E 206 THR LYS PRO LEU LYS ALA PHE THR VAL CYS LEU HIS PHE +SEQRES 4 E 206 TYR THR GLU LEU SER SER THR ARG GLY TYR SER ILE PHE +SEQRES 5 E 206 SER TYR ALA THR LYS ARG GLN ASP ASN GLU ILE LEU ILE +SEQRES 6 E 206 PHE TRP SER LYS ASP ILE GLY TYR SER PHE THR VAL GLY +SEQRES 7 E 206 GLY SER GLU ILE LEU PHE GLU VAL PRO GLU VAL THR VAL +SEQRES 8 E 206 ALA PRO VAL HIS ILE CYS THR SER TRP GLU SER ALA SER +SEQRES 9 E 206 GLY ILE VAL GLU PHE TRP VAL ASP GLY LYS PRO ARG VAL +SEQRES 10 E 206 ARG LYS SER LEU LYS LYS GLY TYR THR VAL GLY ALA GLU +SEQRES 11 E 206 ALA SER ILE ILE LEU GLY GLN GLU GLN ASP SER PHE GLY +SEQRES 12 E 206 GLY ASN PHE GLU GLY SER GLN SER LEU VAL GLY ASP ILE +SEQRES 13 E 206 GLY ASN VAL ASN MET TRP ASP PHE VAL LEU SER PRO ASP +SEQRES 14 E 206 GLU ILE ASN THR ILE TYR LEU GLY GLY PRO PHE SER PRO +SEQRES 15 E 206 ASN VAL LEU ASN TRP ARG ALA LEU LYS TYR GLU VAL GLN +SEQRES 16 E 206 GLY GLU VAL PHE THR LYS PRO GLN LEU TRP PRO +SEQRES 1 F 206 GLN THR ASP MET SER ARG LYS ALA PHE VAL PHE PRO LYS +SEQRES 2 F 206 GLU SER ASP THR SER TYR VAL SER LEU LYS ALA PRO LEU +SEQRES 3 F 206 THR LYS PRO LEU LYS ALA PHE THR VAL CYS LEU HIS PHE +SEQRES 4 F 206 TYR THR GLU LEU SER SER THR ARG GLY TYR SER ILE PHE +SEQRES 5 F 206 SER TYR ALA THR LYS ARG GLN ASP ASN GLU ILE LEU ILE +SEQRES 6 F 206 PHE TRP SER LYS ASP ILE GLY TYR SER PHE THR VAL GLY +SEQRES 7 F 206 GLY SER GLU ILE LEU PHE GLU VAL PRO GLU VAL THR VAL +SEQRES 8 F 206 ALA PRO VAL HIS ILE CYS THR SER TRP GLU SER ALA SER +SEQRES 9 F 206 GLY ILE VAL GLU PHE TRP VAL ASP GLY LYS PRO ARG VAL +SEQRES 10 F 206 ARG LYS SER LEU LYS LYS GLY TYR THR VAL GLY ALA GLU +SEQRES 11 F 206 ALA SER ILE ILE LEU GLY GLN GLU GLN ASP SER PHE GLY +SEQRES 12 F 206 GLY ASN PHE GLU GLY SER GLN SER LEU VAL GLY ASP ILE +SEQRES 13 F 206 GLY ASN VAL ASN MET TRP ASP PHE VAL LEU SER PRO ASP +SEQRES 14 F 206 GLU ILE ASN THR ILE TYR LEU GLY GLY PRO PHE SER PRO +SEQRES 15 F 206 ASN VAL LEU ASN TRP ARG ALA LEU LYS TYR GLU VAL GLN +SEQRES 16 F 206 GLY GLU VAL PHE THR LYS PRO GLN LEU TRP PRO +SEQRES 1 G 206 GLN THR ASP MET SER ARG LYS ALA PHE VAL PHE PRO LYS +SEQRES 2 G 206 GLU SER ASP THR SER TYR VAL SER LEU LYS ALA PRO LEU +SEQRES 3 G 206 THR LYS PRO LEU LYS ALA PHE THR VAL CYS LEU HIS PHE +SEQRES 4 G 206 TYR THR GLU LEU SER SER THR ARG GLY TYR SER ILE PHE +SEQRES 5 G 206 SER TYR ALA THR LYS ARG GLN ASP ASN GLU ILE LEU ILE +SEQRES 6 G 206 PHE TRP SER LYS ASP ILE GLY TYR SER PHE THR VAL GLY +SEQRES 7 G 206 GLY SER GLU ILE LEU PHE GLU VAL PRO GLU VAL THR VAL +SEQRES 8 G 206 ALA PRO VAL HIS ILE CYS THR SER TRP GLU SER ALA SER +SEQRES 9 G 206 GLY ILE VAL GLU PHE TRP VAL ASP GLY LYS PRO ARG VAL +SEQRES 10 G 206 ARG LYS SER LEU LYS LYS GLY TYR THR VAL GLY ALA GLU +SEQRES 11 G 206 ALA SER ILE ILE LEU GLY GLN GLU GLN ASP SER PHE GLY +SEQRES 12 G 206 GLY ASN PHE GLU GLY SER GLN SER LEU VAL GLY ASP ILE +SEQRES 13 G 206 GLY ASN VAL ASN MET TRP ASP PHE VAL LEU SER PRO ASP +SEQRES 14 G 206 GLU ILE ASN THR ILE TYR LEU GLY GLY PRO PHE SER PRO +SEQRES 15 G 206 ASN VAL LEU ASN TRP ARG ALA LEU LYS TYR GLU VAL GLN +SEQRES 16 G 206 GLY GLU VAL PHE THR LYS PRO GLN LEU TRP PRO +SEQRES 1 H 206 GLN THR ASP MET SER ARG LYS ALA PHE VAL PHE PRO LYS +SEQRES 2 H 206 GLU SER ASP THR SER TYR VAL SER LEU LYS ALA PRO LEU +SEQRES 3 H 206 THR LYS PRO LEU LYS ALA PHE THR VAL CYS LEU HIS PHE +SEQRES 4 H 206 TYR THR GLU LEU SER SER THR ARG GLY TYR SER ILE PHE +SEQRES 5 H 206 SER TYR ALA THR LYS ARG GLN ASP ASN GLU ILE LEU ILE +SEQRES 6 H 206 PHE TRP SER LYS ASP ILE GLY TYR SER PHE THR VAL GLY +SEQRES 7 H 206 GLY SER GLU ILE LEU PHE GLU VAL PRO GLU VAL THR VAL +SEQRES 8 H 206 ALA PRO VAL HIS ILE CYS THR SER TRP GLU SER ALA SER +SEQRES 9 H 206 GLY ILE VAL GLU PHE TRP VAL ASP GLY LYS PRO ARG VAL +SEQRES 10 H 206 ARG LYS SER LEU LYS LYS GLY TYR THR VAL GLY ALA GLU +SEQRES 11 H 206 ALA SER ILE ILE LEU GLY GLN GLU GLN ASP SER PHE GLY +SEQRES 12 H 206 GLY ASN PHE GLU GLY SER GLN SER LEU VAL GLY ASP ILE +SEQRES 13 H 206 GLY ASN VAL ASN MET TRP ASP PHE VAL LEU SER PRO ASP +SEQRES 14 H 206 GLU ILE ASN THR ILE TYR LEU GLY GLY PRO PHE SER PRO +SEQRES 15 H 206 ASN VAL LEU ASN TRP ARG ALA LEU LYS TYR GLU VAL GLN +SEQRES 16 H 206 GLY GLU VAL PHE THR LYS PRO GLN LEU TRP PRO +SEQRES 1 I 206 GLN THR ASP MET SER ARG LYS ALA PHE VAL PHE PRO LYS +SEQRES 2 I 206 GLU SER ASP THR SER TYR VAL SER LEU LYS ALA PRO LEU +SEQRES 3 I 206 THR LYS PRO LEU LYS ALA PHE THR VAL CYS LEU HIS PHE +SEQRES 4 I 206 TYR THR GLU LEU SER SER THR ARG GLY TYR SER ILE PHE +SEQRES 5 I 206 SER TYR ALA THR LYS ARG GLN ASP ASN GLU ILE LEU ILE +SEQRES 6 I 206 PHE TRP SER LYS ASP ILE GLY TYR SER PHE THR VAL GLY +SEQRES 7 I 206 GLY SER GLU ILE LEU PHE GLU VAL PRO GLU VAL THR VAL +SEQRES 8 I 206 ALA PRO VAL HIS ILE CYS THR SER TRP GLU SER ALA SER +SEQRES 9 I 206 GLY ILE VAL GLU PHE TRP VAL ASP GLY LYS PRO ARG VAL +SEQRES 10 I 206 ARG LYS SER LEU LYS LYS GLY TYR THR VAL GLY ALA GLU +SEQRES 11 I 206 ALA SER ILE ILE LEU GLY GLN GLU GLN ASP SER PHE GLY +SEQRES 12 I 206 GLY ASN PHE GLU GLY SER GLN SER LEU VAL GLY ASP ILE +SEQRES 13 I 206 GLY ASN VAL ASN MET TRP ASP PHE VAL LEU SER PRO ASP +SEQRES 14 I 206 GLU ILE ASN THR ILE TYR LEU GLY GLY PRO PHE SER PRO +SEQRES 15 I 206 ASN VAL LEU ASN TRP ARG ALA LEU LYS TYR GLU VAL GLN +SEQRES 16 I 206 GLY GLU VAL PHE THR LYS PRO GLN LEU TRP PRO +SEQRES 1 J 206 GLN THR ASP MET SER ARG LYS ALA PHE VAL PHE PRO LYS +SEQRES 2 J 206 GLU SER ASP THR SER TYR VAL SER LEU LYS ALA PRO LEU +SEQRES 3 J 206 THR LYS PRO LEU LYS ALA PHE THR VAL CYS LEU HIS PHE +SEQRES 4 J 206 TYR THR GLU LEU SER SER THR ARG GLY TYR SER ILE PHE +SEQRES 5 J 206 SER TYR ALA THR LYS ARG GLN ASP ASN GLU ILE LEU ILE +SEQRES 6 J 206 PHE TRP SER LYS ASP ILE GLY TYR SER PHE THR VAL GLY +SEQRES 7 J 206 GLY SER GLU ILE LEU PHE GLU VAL PRO GLU VAL THR VAL +SEQRES 8 J 206 ALA PRO VAL HIS ILE CYS THR SER TRP GLU SER ALA SER +SEQRES 9 J 206 GLY ILE VAL GLU PHE TRP VAL ASP GLY LYS PRO ARG VAL +SEQRES 10 J 206 ARG LYS SER LEU LYS LYS GLY TYR THR VAL GLY ALA GLU +SEQRES 11 J 206 ALA SER ILE ILE LEU GLY GLN GLU GLN ASP SER PHE GLY +SEQRES 12 J 206 GLY ASN PHE GLU GLY SER GLN SER LEU VAL GLY ASP ILE +SEQRES 13 J 206 GLY ASN VAL ASN MET TRP ASP PHE VAL LEU SER PRO ASP +SEQRES 14 J 206 GLU ILE ASN THR ILE TYR LEU GLY GLY PRO PHE SER PRO +SEQRES 15 J 206 ASN VAL LEU ASN TRP ARG ALA LEU LYS TYR GLU VAL GLN +SEQRES 16 J 206 GLY GLU VAL PHE THR LYS PRO GLN LEU TRP PRO +HET CA A 501 1 +HET CA A 502 1 +HET CA B 501 1 +HET CA B 502 1 +HET CA C 501 1 +HET CA C 502 1 +HET CA E 501 1 +HET CA E 502 1 +HET CA F 501 1 +HET CA F 502 1 +HET CA G 501 1 +HET CA G 502 1 +HET CA H 501 1 +HET CA H 502 1 +HET CA I 501 1 +HET CA I 502 1 +HETNAM CA CALCIUM ION +FORMUL 11 CA 16(CA 2+) +HELIX 1 1 LEU A 43 SER A 45 5 3 +HELIX 2 2 GLY A 148 GLN A 150 5 3 +HELIX 3 3 PRO A 168 LEU A 176 1 9 +HELIX 4 4 TRP A 187 ALA A 189 5 3 +HELIX 5 5 LEU B 43 SER B 45 5 3 +HELIX 6 6 GLY B 148 GLN B 150 5 3 +HELIX 7 7 PRO B 168 LEU B 176 1 9 +HELIX 8 8 TRP B 187 ALA B 189 5 3 +HELIX 9 9 LEU C 43 SER C 45 5 3 +HELIX 10 10 GLY C 148 GLN C 150 5 3 +HELIX 11 11 PRO C 168 LEU C 176 1 9 +HELIX 12 12 TRP C 187 ALA C 189 5 3 +HELIX 13 13 PRO D 168 LEU D 176 1 9 +HELIX 14 14 TRP D 187 ALA D 189 5 3 +HELIX 15 15 LEU E 43 SER E 45 5 3 +HELIX 16 16 GLY E 148 GLN E 150 5 3 +HELIX 17 17 PRO E 168 LEU E 176 1 9 +HELIX 18 18 TRP E 187 ALA E 189 5 3 +HELIX 19 19 LEU F 43 SER F 45 5 3 +HELIX 20 20 GLY F 148 GLN F 150 5 3 +HELIX 21 21 PRO F 168 LEU F 176 1 9 +HELIX 22 22 TRP F 187 ALA F 189 5 3 +HELIX 23 23 LEU G 43 SER G 45 5 3 +HELIX 24 24 GLY G 148 GLN G 150 5 3 +HELIX 25 25 PRO G 168 LEU G 176 1 9 +HELIX 26 26 TRP G 187 ALA G 189 5 3 +HELIX 27 27 LEU H 43 SER H 45 5 3 +HELIX 28 28 GLY H 148 GLN H 150 5 3 +HELIX 29 29 PRO H 168 LEU H 176 1 9 +HELIX 30 30 TRP H 187 ALA H 189 5 3 +HELIX 31 31 LEU I 43 SER I 45 5 3 +HELIX 32 32 GLY I 148 GLN I 150 5 3 +HELIX 33 33 PRO I 168 LEU I 176 1 9 +HELIX 34 34 TRP I 187 ALA I 189 5 3 +HELIX 35 35 PRO J 168 LEU J 176 1 9 +HELIX 36 36 TRP J 187 ALA J 189 5 3 +SHEET 1 A 6 PHE A 199 PRO A 202 0 +SHEET 2 A 6 LYS A 7 PHE A 11 -1 N VAL A 10 O PHE A 199 +SHEET 3 A 6 GLY A 154 GLY A 157 -1 N ILE A 156 O PHE A 9 +SHEET 4 A 6 ALA A 32 THR A 41 -1 N TYR A 40 O ASP A 155 +SHEET 5 A 6 VAL A 94 GLU A 101 -1 N TRP A 100 O PHE A 33 +SHEET 6 A 6 VAL A 107 VAL A 111 -1 N TRP A 110 O CYS A 97 +SHEET 1 B 7 TYR A 192 GLN A 195 0 +SHEET 2 B 7 TYR A 19 LEU A 22 -1 N SER A 21 O GLU A 193 +SHEET 3 B 7 SER A 132 LEU A 135 -1 N LEU A 135 O VAL A 20 +SHEET 4 B 7 TYR A 49 ALA A 55 -1 N ALA A 55 O SER A 132 +SHEET 5 B 7 ILE A 63 SER A 68 -1 N TRP A 67 O TYR A 49 +SHEET 6 B 7 GLY A 72 VAL A 77 -1 N THR A 76 O LEU A 64 +SHEET 7 B 7 SER A 80 GLU A 85 -1 N PHE A 84 O TYR A 73 +SHEET 1 C 2 THR A 34 CYS A 36 0 +SHEET 2 C 2 ASN A 160 TRP A 162 -1 N TRP A 162 O THR A 34 +SHEET 1 D 6 PHE B 199 PRO B 202 0 +SHEET 2 D 6 LYS B 7 PHE B 11 -1 N VAL B 10 O PHE B 199 +SHEET 3 D 6 GLY B 154 GLY B 157 -1 N ILE B 156 O PHE B 9 +SHEET 4 D 6 ALA B 32 THR B 41 -1 N TYR B 40 O ASP B 155 +SHEET 5 D 6 VAL B 94 GLU B 101 -1 N TRP B 100 O PHE B 33 +SHEET 6 D 6 VAL B 107 VAL B 111 -1 N TRP B 110 O CYS B 97 +SHEET 1 E 7 TYR B 192 GLN B 195 0 +SHEET 2 E 7 TYR B 19 LEU B 22 -1 N SER B 21 O GLU B 193 +SHEET 3 E 7 SER B 132 LEU B 135 -1 N LEU B 135 O VAL B 20 +SHEET 4 E 7 TYR B 49 ALA B 55 -1 N ALA B 55 O SER B 132 +SHEET 5 E 7 ILE B 63 SER B 68 -1 N TRP B 67 O TYR B 49 +SHEET 6 E 7 GLY B 72 VAL B 77 -1 N THR B 76 O LEU B 64 +SHEET 7 E 7 SER B 80 GLU B 85 -1 N PHE B 84 O TYR B 73 +SHEET 1 F 2 THR B 34 CYS B 36 0 +SHEET 2 F 2 ASN B 160 TRP B 162 -1 N TRP B 162 O THR B 34 +SHEET 1 G 6 PHE C 199 PRO C 202 0 +SHEET 2 G 6 LYS C 7 PHE C 11 -1 N VAL C 10 O PHE C 199 +SHEET 3 G 6 GLY C 154 GLY C 157 -1 N ILE C 156 O PHE C 9 +SHEET 4 G 6 ALA C 32 THR C 41 -1 N TYR C 40 O ASP C 155 +SHEET 5 G 6 VAL C 94 GLU C 101 -1 N TRP C 100 O PHE C 33 +SHEET 6 G 6 VAL C 107 VAL C 111 -1 N TRP C 110 O CYS C 97 +SHEET 1 H 7 TYR C 192 GLN C 195 0 +SHEET 2 H 7 TYR C 19 LEU C 22 -1 N SER C 21 O GLU C 193 +SHEET 3 H 7 SER C 132 LEU C 135 -1 N LEU C 135 O VAL C 20 +SHEET 4 H 7 TYR C 49 ALA C 55 -1 N ALA C 55 O SER C 132 +SHEET 5 H 7 ILE C 63 SER C 68 -1 N TRP C 67 O TYR C 49 +SHEET 6 H 7 GLY C 72 VAL C 77 -1 N THR C 76 O LEU C 64 +SHEET 7 H 7 SER C 80 GLU C 85 -1 N PHE C 84 O TYR C 73 +SHEET 1 I 2 THR C 34 CYS C 36 0 +SHEET 2 I 2 ASN C 160 TRP C 162 -1 N TRP C 162 O THR C 34 +SHEET 1 J 6 PHE D 199 PRO D 202 0 +SHEET 2 J 6 LYS D 7 PHE D 11 -1 N VAL D 10 O PHE D 199 +SHEET 3 J 6 GLY D 154 GLY D 157 -1 N ILE D 156 O PHE D 9 +SHEET 4 J 6 ALA D 32 THR D 41 -1 N TYR D 40 O ASP D 155 +SHEET 5 J 6 VAL D 94 GLU D 101 -1 N TRP D 100 O PHE D 33 +SHEET 6 J 6 VAL D 107 VAL D 111 -1 N TRP D 110 O CYS D 97 +SHEET 1 K 7 TYR D 192 GLN D 195 0 +SHEET 2 K 7 TYR D 19 LEU D 22 -1 N SER D 21 O GLU D 193 +SHEET 3 K 7 SER D 132 LEU D 135 -1 N LEU D 135 O VAL D 20 +SHEET 4 K 7 TYR D 49 ALA D 55 -1 N ALA D 55 O SER D 132 +SHEET 5 K 7 ILE D 63 SER D 68 -1 N TRP D 67 O TYR D 49 +SHEET 6 K 7 GLY D 72 VAL D 77 -1 N THR D 76 O LEU D 64 +SHEET 7 K 7 SER D 80 PHE D 84 -1 N PHE D 84 O TYR D 73 +SHEET 1 L 2 THR D 34 CYS D 36 0 +SHEET 2 L 2 ASN D 160 TRP D 162 -1 N TRP D 162 O THR D 34 +SHEET 1 M 6 PHE E 199 PRO E 202 0 +SHEET 2 M 6 LYS E 7 PHE E 11 -1 N VAL E 10 O PHE E 199 +SHEET 3 M 6 GLY E 154 GLY E 157 -1 N ILE E 156 O PHE E 9 +SHEET 4 M 6 ALA E 32 THR E 41 -1 N TYR E 40 O ASP E 155 +SHEET 5 M 6 VAL E 94 GLU E 101 -1 N TRP E 100 O PHE E 33 +SHEET 6 M 6 VAL E 107 VAL E 111 -1 N TRP E 110 O CYS E 97 +SHEET 1 N 7 TYR E 192 GLN E 195 0 +SHEET 2 N 7 TYR E 19 LEU E 22 -1 N SER E 21 O GLU E 193 +SHEET 3 N 7 SER E 132 LEU E 135 -1 N LEU E 135 O VAL E 20 +SHEET 4 N 7 TYR E 49 ALA E 55 -1 N ALA E 55 O SER E 132 +SHEET 5 N 7 ILE E 63 SER E 68 -1 N TRP E 67 O TYR E 49 +SHEET 6 N 7 GLY E 72 VAL E 77 -1 N THR E 76 O LEU E 64 +SHEET 7 N 7 SER E 80 GLU E 85 -1 N PHE E 84 O TYR E 73 +SHEET 1 O 2 THR E 34 CYS E 36 0 +SHEET 2 O 2 ASN E 160 TRP E 162 -1 N TRP E 162 O THR E 34 +SHEET 1 P 6 PHE F 199 PRO F 202 0 +SHEET 2 P 6 LYS F 7 PHE F 11 -1 N VAL F 10 O PHE F 199 +SHEET 3 P 6 GLY F 154 GLY F 157 -1 N ILE F 156 O PHE F 9 +SHEET 4 P 6 ALA F 32 THR F 41 -1 N TYR F 40 O ASP F 155 +SHEET 5 P 6 VAL F 94 GLU F 101 -1 N TRP F 100 O PHE F 33 +SHEET 6 P 6 VAL F 107 VAL F 111 -1 N TRP F 110 O CYS F 97 +SHEET 1 Q 7 TYR F 192 GLN F 195 0 +SHEET 2 Q 7 TYR F 19 LEU F 22 -1 N SER F 21 O GLU F 193 +SHEET 3 Q 7 SER F 132 LEU F 135 -1 N LEU F 135 O VAL F 20 +SHEET 4 Q 7 TYR F 49 ALA F 55 -1 N ALA F 55 O SER F 132 +SHEET 5 Q 7 ILE F 63 SER F 68 -1 N TRP F 67 O TYR F 49 +SHEET 6 Q 7 GLY F 72 VAL F 77 -1 N THR F 76 O LEU F 64 +SHEET 7 Q 7 SER F 80 GLU F 85 -1 N PHE F 84 O TYR F 73 +SHEET 1 R 2 THR F 34 CYS F 36 0 +SHEET 2 R 2 ASN F 160 TRP F 162 -1 N TRP F 162 O THR F 34 +SHEET 1 S 6 PHE G 199 PRO G 202 0 +SHEET 2 S 6 LYS G 7 PHE G 11 -1 N VAL G 10 O PHE G 199 +SHEET 3 S 6 GLY G 154 GLY G 157 -1 N ILE G 156 O PHE G 9 +SHEET 4 S 6 ALA G 32 THR G 41 -1 N TYR G 40 O ASP G 155 +SHEET 5 S 6 VAL G 94 GLU G 101 -1 N TRP G 100 O PHE G 33 +SHEET 6 S 6 VAL G 107 VAL G 111 -1 N TRP G 110 O CYS G 97 +SHEET 1 T 7 TYR G 192 GLN G 195 0 +SHEET 2 T 7 TYR G 19 LEU G 22 -1 N SER G 21 O GLU G 193 +SHEET 3 T 7 SER G 132 LEU G 135 -1 N LEU G 135 O VAL G 20 +SHEET 4 T 7 TYR G 49 ALA G 55 -1 N ALA G 55 O SER G 132 +SHEET 5 T 7 ILE G 63 SER G 68 -1 N TRP G 67 O TYR G 49 +SHEET 6 T 7 GLY G 72 VAL G 77 -1 N THR G 76 O LEU G 64 +SHEET 7 T 7 SER G 80 GLU G 85 -1 N PHE G 84 O TYR G 73 +SHEET 1 U 2 THR G 34 CYS G 36 0 +SHEET 2 U 2 ASN G 160 TRP G 162 -1 N TRP G 162 O THR G 34 +SHEET 1 V 6 PHE H 199 PRO H 202 0 +SHEET 2 V 6 LYS H 7 PHE H 11 -1 N VAL H 10 O PHE H 199 +SHEET 3 V 6 GLY H 154 GLY H 157 -1 N ILE H 156 O PHE H 9 +SHEET 4 V 6 ALA H 32 THR H 41 -1 N TYR H 40 O ASP H 155 +SHEET 5 V 6 VAL H 94 GLU H 101 -1 N TRP H 100 O PHE H 33 +SHEET 6 V 6 VAL H 107 VAL H 111 -1 N TRP H 110 O CYS H 97 +SHEET 1 W 7 TYR H 192 GLN H 195 0 +SHEET 2 W 7 TYR H 19 LEU H 22 -1 N SER H 21 O GLU H 193 +SHEET 3 W 7 SER H 132 LEU H 135 -1 N LEU H 135 O VAL H 20 +SHEET 4 W 7 TYR H 49 ALA H 55 -1 N ALA H 55 O SER H 132 +SHEET 5 W 7 ILE H 63 SER H 68 -1 N TRP H 67 O TYR H 49 +SHEET 6 W 7 GLY H 72 VAL H 77 -1 N THR H 76 O LEU H 64 +SHEET 7 W 7 SER H 80 GLU H 85 -1 N PHE H 84 O TYR H 73 +SHEET 1 X 2 THR H 34 CYS H 36 0 +SHEET 2 X 2 ASN H 160 TRP H 162 -1 N TRP H 162 O THR H 34 +SHEET 1 Y 6 PHE I 199 PRO I 202 0 +SHEET 2 Y 6 LYS I 7 PHE I 11 -1 N VAL I 10 O PHE I 199 +SHEET 3 Y 6 GLY I 154 GLY I 157 -1 N ILE I 156 O PHE I 9 +SHEET 4 Y 6 ALA I 32 THR I 41 -1 N TYR I 40 O ASP I 155 +SHEET 5 Y 6 VAL I 94 GLU I 101 -1 N TRP I 100 O PHE I 33 +SHEET 6 Y 6 VAL I 107 VAL I 111 -1 N TRP I 110 O CYS I 97 +SHEET 1 Z 7 TYR I 192 GLN I 195 0 +SHEET 2 Z 7 TYR I 19 LEU I 22 -1 N SER I 21 O GLU I 193 +SHEET 3 Z 7 SER I 132 LEU I 135 -1 N LEU I 135 O VAL I 20 +SHEET 4 Z 7 TYR I 49 ALA I 55 -1 N ALA I 55 O SER I 132 +SHEET 5 Z 7 ILE I 63 SER I 68 -1 N TRP I 67 O TYR I 49 +SHEET 6 Z 7 GLY I 72 VAL I 77 -1 N THR I 76 O LEU I 64 +SHEET 7 Z 7 SER I 80 GLU I 85 -1 N PHE I 84 O TYR I 73 +SHEET 1 1A 2 THR I 34 CYS I 36 0 +SHEET 2 1A 2 ASN I 160 TRP I 162 -1 N TRP I 162 O THR I 34 +SHEET 1 1B 6 PHE J 199 PRO J 202 0 +SHEET 2 1B 6 LYS J 7 PHE J 11 -1 N VAL J 10 O PHE J 199 +SHEET 3 1B 6 GLY J 154 GLY J 157 -1 N ILE J 156 O PHE J 9 +SHEET 4 1B 6 ALA J 32 THR J 41 -1 N TYR J 40 O ASP J 155 +SHEET 5 1B 6 VAL J 94 GLU J 101 -1 N TRP J 100 O PHE J 33 +SHEET 6 1B 6 VAL J 107 VAL J 111 -1 N TRP J 110 O CYS J 97 +SHEET 1 1C 7 TYR J 192 GLN J 195 0 +SHEET 2 1C 7 TYR J 19 LEU J 22 -1 N SER J 21 O GLU J 193 +SHEET 3 1C 7 SER J 132 LEU J 135 -1 N LEU J 135 O VAL J 20 +SHEET 4 1C 7 TYR J 49 ALA J 55 -1 N ALA J 55 O SER J 132 +SHEET 5 1C 7 ILE J 63 SER J 68 -1 N TRP J 67 O TYR J 49 +SHEET 6 1C 7 GLY J 72 VAL J 77 -1 N THR J 76 O LEU J 64 +SHEET 7 1C 7 SER J 80 PHE J 84 -1 N PHE J 84 O TYR J 73 +SHEET 1 1D 2 THR J 34 CYS J 36 0 +SHEET 2 1D 2 ASN J 160 TRP J 162 -1 N TRP J 162 O THR J 34 +SSBOND 1 CYS A 36 CYS A 97 1555 1555 2.03 +SSBOND 2 CYS B 36 CYS B 97 1555 1555 2.02 +SSBOND 3 CYS C 36 CYS C 97 1555 1555 2.03 +SSBOND 4 CYS D 36 CYS D 97 1555 1555 2.01 +SSBOND 5 CYS E 36 CYS E 97 1555 1555 2.02 +SSBOND 6 CYS F 36 CYS F 97 1555 1555 2.03 +SSBOND 7 CYS G 36 CYS G 97 1555 1555 2.04 +SSBOND 8 CYS H 36 CYS H 97 1555 1555 2.01 +SSBOND 9 CYS I 36 CYS I 97 1555 1555 2.03 +SSBOND 10 CYS J 36 CYS J 97 1555 1555 2.02 +LINK OD2 ASP A 60 CA CA A 501 1555 1555 3.24 +LINK OD1 ASN A 61 CA CA A 501 1555 1555 3.03 +LINK ND2 ASN A 61 CA CA A 501 1555 1555 3.00 +LINK OE1 GLU A 138 CA CA A 501 1555 1555 2.43 +LINK OE2 GLU A 138 CA CA A 501 1555 1555 2.79 +LINK OE1 GLU A 138 CA CA A 502 1555 1555 2.54 +LINK O GLN A 139 CA CA A 501 1555 1555 2.64 +LINK OD1 ASP A 140 CA CA A 501 1555 1555 1.80 +LINK OD2 ASP A 140 CA CA A 502 1555 1555 2.43 +LINK OD1 ASP A 140 CA CA A 502 1555 1555 3.39 +LINK OE1 GLN A 150 CA CA A 502 1555 1555 2.10 +LINK OD1 ASN B 61 CA CA B 501 1555 1555 3.15 +LINK ND2 ASN B 61 CA CA B 501 1555 1555 3.17 +LINK CD GLU B 138 CA CA B 501 1555 1555 2.22 +LINK OE1 GLU B 138 CA CA B 501 1555 1555 1.80 +LINK OE2 GLU B 138 CA CA B 501 1555 1555 2.29 +LINK OE1 GLU B 138 CA CA B 502 1555 1555 2.20 +LINK O GLN B 139 CA CA B 501 1555 1555 3.22 +LINK OD1 ASP B 140 CA CA B 501 1555 1555 2.63 +LINK OD2 ASP B 140 CA CA B 502 1555 1555 2.09 +LINK OD1 ASP B 140 CA CA B 502 1555 1555 3.03 +LINK OE1 GLN B 150 CA CA B 502 1555 1555 2.30 +LINK OD2 ASP C 60 CA CA C 501 1555 1555 3.30 +LINK ND2 ASN C 61 CA CA C 501 1555 1555 3.10 +LINK OD1 ASN C 61 CA CA C 501 1555 1555 2.70 +LINK OE1 GLU C 138 CA CA C 501 1555 1555 2.39 +LINK OE2 GLU C 138 CA CA C 501 1555 1555 2.46 +LINK OE1 GLU C 138 CA CA C 502 1555 1555 2.04 +LINK O GLN C 139 CA CA C 501 1555 1555 2.35 +LINK OD1 ASP C 140 CA CA C 501 1555 1555 1.98 +LINK OD2 ASP C 140 CA CA C 502 1555 1555 2.00 +LINK OD1 ASP C 140 CA CA C 502 1555 1555 2.88 +LINK OE1 GLU C 147 CA CA C 502 1555 1555 1.99 +LINK OE1 GLN C 150 CA CA C 502 1555 1555 2.32 +LINK CA CA C 501 OE1 GLU D 147 1555 4555 3.15 +LINK OD2 ASP E 60 CA CA E 501 1555 1555 2.74 +LINK OD1 ASN E 61 CA CA E 501 1555 1555 2.84 +LINK ND2 ASN E 61 CA CA E 501 1555 1555 2.78 +LINK OE1 GLU E 138 CA CA E 501 1555 1555 2.87 +LINK OE2 GLU E 138 CA CA E 501 1555 1555 3.03 +LINK OE1 GLU E 138 CA CA E 502 1555 1555 2.15 +LINK O GLN E 139 CA CA E 501 1555 1555 2.53 +LINK OD1 ASP E 140 CA CA E 501 1555 1555 1.92 +LINK OD2 ASP E 140 CA CA E 502 1555 1555 2.28 +LINK OD1 ASP E 140 CA CA E 502 1555 1555 2.94 +LINK OE1 GLN E 150 CA CA E 502 1555 1555 2.22 +LINK OD1 ASN F 61 CA CA F 501 1555 1555 2.94 +LINK OE1 GLU F 138 CA CA F 501 1555 1555 2.11 +LINK OE2 GLU F 138 CA CA F 501 1555 1555 2.98 +LINK OE1 GLU F 138 CA CA F 502 1555 1555 2.10 +LINK OD1 ASP F 140 CA CA F 501 1555 1555 2.45 +LINK OD2 ASP F 140 CA CA F 502 1555 1555 2.16 +LINK OD1 ASP F 140 CA CA F 502 1555 1555 3.02 +LINK OE1 GLU F 147 CA CA F 502 1555 1555 3.29 +LINK OE2 GLU F 147 CA CA F 502 1555 1555 2.83 +LINK OE1 GLN F 150 CA CA F 502 1555 1555 2.23 +LINK OD2 ASP G 60 CA CA G 501 1555 1555 3.11 +LINK OD1 ASN G 61 CA CA G 501 1555 1555 2.50 +LINK ND2 ASN G 61 CA CA G 501 1555 1555 2.66 +LINK OE1 GLU G 138 CA CA G 501 1555 1555 2.75 +LINK OE2 GLU G 138 CA CA G 501 1555 1555 2.93 +LINK OE1 GLU G 138 CA CA G 502 1555 1555 2.20 +LINK O GLN G 139 CA CA G 501 1555 1555 2.83 +LINK OD1 ASP G 140 CA CA G 501 1555 1555 2.24 +LINK OD1 ASP G 140 CA CA G 502 1555 1555 2.83 +LINK OD2 ASP G 140 CA CA G 502 1555 1555 2.98 +LINK OE1 GLN G 150 CA CA G 502 1555 1555 2.85 +LINK OD2 ASP H 60 CA CA H 501 1555 1555 3.25 +LINK OD1 ASN H 61 CA CA H 501 1555 1555 2.88 +LINK ND2 ASN H 61 CA CA H 501 1555 1555 2.96 +LINK OE1 GLU H 138 CA CA H 501 1555 1555 2.47 +LINK OE2 GLU H 138 CA CA H 501 1555 1555 2.86 +LINK OE1 GLU H 138 CA CA H 502 1555 1555 2.11 +LINK O GLN H 139 CA CA H 501 1555 1555 2.77 +LINK OD1 ASP H 140 CA CA H 501 1555 1555 1.89 +LINK OD2 ASP H 140 CA CA H 502 1555 1555 1.90 +LINK OD1 ASP H 140 CA CA H 502 1555 1555 2.76 +LINK OE2 GLU H 147 CA CA H 502 1555 1555 2.63 +LINK OE1 GLN H 150 CA CA H 502 1555 1555 2.52 +LINK OD2 ASP I 60 CA CA I 501 1555 1555 2.62 +LINK OD1 ASN I 61 CA CA I 501 1555 1555 2.46 +LINK ND2 ASN I 61 CA CA I 501 1555 1555 2.91 +LINK OE2 GLU I 138 CA CA I 501 1555 1555 2.94 +LINK OE1 GLU I 138 CA CA I 501 1555 1555 3.02 +LINK OE1 GLU I 138 CA CA I 502 1555 1555 2.31 +LINK O GLN I 139 CA CA I 501 1555 1555 2.24 +LINK OD1 ASP I 140 CA CA I 501 1555 1555 2.09 +LINK OD2 ASP I 140 CA CA I 502 1555 1555 1.90 +LINK OD1 ASP I 140 CA CA I 502 1555 1555 2.85 +LINK OE1 GLU I 147 CA CA I 502 1555 1555 2.09 +LINK OE1 GLN I 150 CA CA I 502 1555 1555 2.52 +LINK CA CA I 501 OE1 GLU J 147 1555 4556 2.59 +LINK CA CA I 502 OE2 GLU J 147 1555 4556 2.02 +SITE 1 AC1 5 ASP A 60 ASN A 61 GLU A 138 GLN A 139 +SITE 2 AC1 5 ASP A 140 +SITE 1 AC2 3 GLU A 138 ASP A 140 GLN A 150 +SITE 1 AC3 5 ASN B 61 GLU B 138 GLN B 139 ASP B 140 +SITE 2 AC3 5 CA B 502 +SITE 1 AC4 4 GLU B 138 ASP B 140 GLN B 150 CA B 501 +SITE 1 AC5 6 ASP C 60 ASN C 61 GLU C 138 GLN C 139 +SITE 2 AC5 6 ASP C 140 GLU D 147 +SITE 1 AC6 4 GLU C 138 ASP C 140 GLU C 147 GLN C 150 +SITE 1 AC7 5 ASP E 60 ASN E 61 GLU E 138 GLN E 139 +SITE 2 AC7 5 ASP E 140 +SITE 1 AC8 3 GLU E 138 ASP E 140 GLN E 150 +SITE 1 AC9 5 ASN F 61 GLU F 138 GLN F 139 ASP F 140 +SITE 2 AC9 5 CA F 502 +SITE 1 BC1 5 GLU F 138 ASP F 140 GLU F 147 GLN F 150 +SITE 2 BC1 5 CA F 501 +SITE 1 BC2 6 ASP G 60 ASN G 61 GLU G 138 GLN G 139 +SITE 2 BC2 6 ASP G 140 CA G 502 +SITE 1 BC3 4 GLU G 138 ASP G 140 GLN G 150 CA G 501 +SITE 1 BC4 5 ASP H 60 ASN H 61 GLU H 138 GLN H 139 +SITE 2 BC4 5 ASP H 140 +SITE 1 BC5 4 GLU H 138 ASP H 140 GLU H 147 GLN H 150 +SITE 1 BC6 6 ASP I 60 ASN I 61 GLU I 138 GLN I 139 +SITE 2 BC6 6 ASP I 140 GLU J 147 +SITE 1 BC7 5 GLU I 138 ASP I 140 GLU I 147 GLN I 150 +SITE 2 BC7 5 GLU J 147 +CRYST1 101.060 154.250 242.930 90.00 90.00 90.00 P 21 21 21 40 +ORIGX1 1.000000 0.000000 0.000000 0.00000 +ORIGX2 0.000000 1.000000 0.000000 0.00000 +ORIGX3 0.000000 0.000000 1.000000 0.00000 +SCALE1 0.009895 0.000000 0.000000 0.00000 +SCALE2 0.000000 0.006483 0.000000 0.00000 +SCALE3 0.000000 0.000000 0.004116 0.00000 +ATOM 1 N GLN A 1 28.649 81.361 63.308 1.00 61.86 N +ATOM 2 CA GLN A 1 29.141 82.500 62.470 1.00 53.34 C +ATOM 3 C GLN A 1 30.422 82.021 61.809 1.00 51.78 C +ATOM 4 O GLN A 1 31.493 82.582 62.052 1.00 57.70 O +ATOM 5 CB GLN A 1 29.562 83.703 63.339 1.00 53.61 C +ATOM 6 CG GLN A 1 28.656 84.092 64.477 1.00 50.72 C +ATOM 7 CD GLN A 1 27.696 85.160 64.079 1.00 37.83 C +ATOM 8 OE1 GLN A 1 27.012 85.027 63.069 1.00 28.15 O +ATOM 9 NE2 GLN A 1 27.641 86.239 64.857 1.00 29.31 N +ATOM 10 N THR A 2 30.333 80.969 61.009 1.00 44.55 N +ATOM 11 CA THR A 2 31.514 80.437 60.344 1.00 35.62 C +ATOM 12 C THR A 2 31.310 80.503 58.843 1.00 31.05 C +ATOM 13 O THR A 2 30.210 80.259 58.346 1.00 34.10 O +ATOM 14 CB THR A 2 31.745 78.986 60.750 1.00 32.23 C +ATOM 15 OG1 THR A 2 31.649 78.872 62.176 1.00 41.95 O +ATOM 16 CG2 THR A 2 33.111 78.523 60.307 1.00 41.74 C +ATOM 17 N ASP A 3 32.347 80.902 58.128 1.00 27.03 N +ATOM 18 CA ASP A 3 32.248 80.980 56.689 1.00 24.59 C +ATOM 19 C ASP A 3 32.544 79.578 56.179 1.00 27.87 C +ATOM 20 O ASP A 3 33.717 79.153 56.074 1.00 27.97 O +ATOM 21 CB ASP A 3 33.254 81.979 56.130 1.00 35.97 C +ATOM 22 CG ASP A 3 32.925 82.388 54.714 1.00 42.46 C +ATOM 23 OD1 ASP A 3 32.049 81.724 54.097 1.00 35.99 O +ATOM 24 OD2 ASP A 3 33.529 83.382 54.231 1.00 54.10 O +ATOM 25 N MET A 4 31.471 78.847 55.898 1.00 24.78 N +ATOM 26 CA MET A 4 31.586 77.465 55.423 1.00 19.64 C +ATOM 27 C MET A 4 31.902 77.348 53.936 1.00 19.70 C +ATOM 28 O MET A 4 31.796 76.250 53.361 1.00 17.86 O +ATOM 29 CB MET A 4 30.316 76.674 55.752 1.00 10.23 C +ATOM 30 CG MET A 4 30.165 76.365 57.228 1.00 18.05 C +ATOM 31 SD MET A 4 31.604 75.425 57.808 1.00 30.88 S +ATOM 32 CE MET A 4 31.160 73.824 57.305 1.00 14.54 C +ATOM 33 N SER A 5 32.316 78.464 53.326 1.00 15.85 N +ATOM 34 CA SER A 5 32.653 78.500 51.910 1.00 14.98 C +ATOM 35 C SER A 5 33.705 77.472 51.502 1.00 17.43 C +ATOM 36 O SER A 5 34.746 77.332 52.154 1.00 21.61 O +ATOM 37 CB SER A 5 33.140 79.890 51.509 1.00 17.57 C +ATOM 38 OG SER A 5 32.059 80.798 51.412 1.00 22.98 O +ATOM 39 N ARG A 6 33.419 76.783 50.394 1.00 18.88 N +ATOM 40 CA ARG A 6 34.287 75.765 49.821 1.00 14.77 C +ATOM 41 C ARG A 6 34.444 74.533 50.729 1.00 17.40 C +ATOM 42 O ARG A 6 35.316 73.691 50.508 1.00 23.64 O +ATOM 43 CB ARG A 6 35.628 76.383 49.426 1.00 8.50 C +ATOM 44 CG ARG A 6 36.244 75.788 48.185 1.00 8.50 C +ATOM 45 CD ARG A 6 35.860 76.520 46.891 1.00 8.50 C +ATOM 46 NE ARG A 6 36.775 76.203 45.780 1.00 26.41 N +ATOM 47 CZ ARG A 6 38.112 76.075 45.870 1.00 36.39 C +ATOM 48 NH1 ARG A 6 38.769 76.218 47.025 1.00 36.26 N +ATOM 49 NH2 ARG A 6 38.825 75.849 44.774 1.00 33.90 N +ATOM 50 N LYS A 7 33.556 74.399 51.715 1.00 16.02 N +ATOM 51 CA LYS A 7 33.594 73.267 52.632 1.00 11.39 C +ATOM 52 C LYS A 7 32.307 72.466 52.597 1.00 10.56 C +ATOM 53 O LYS A 7 31.276 72.940 52.094 1.00 9.65 O +ATOM 54 CB LYS A 7 33.895 73.751 54.051 1.00 19.42 C +ATOM 55 CG LYS A 7 35.332 74.239 54.233 1.00 21.14 C +ATOM 56 CD LYS A 7 35.472 75.119 55.456 1.00 29.94 C +ATOM 57 CE LYS A 7 36.881 75.648 55.575 1.00 43.30 C +ATOM 58 NZ LYS A 7 36.954 76.681 56.638 1.00 57.86 N +ATOM 59 N ALA A 8 32.386 71.236 53.102 1.00 9.84 N +ATOM 60 CA ALA A 8 31.240 70.330 53.135 1.00 9.48 C +ATOM 61 C ALA A 8 31.347 69.485 54.376 1.00 8.50 C +ATOM 62 O ALA A 8 32.449 69.262 54.872 1.00 8.50 O +ATOM 63 CB ALA A 8 31.241 69.432 51.908 1.00 9.53 C +ATOM 64 N PHE A 9 30.200 69.107 54.931 1.00 9.01 N +ATOM 65 CA PHE A 9 30.173 68.241 56.102 1.00 10.25 C +ATOM 66 C PHE A 9 30.209 66.834 55.494 1.00 14.94 C +ATOM 67 O PHE A 9 29.509 66.576 54.495 1.00 13.84 O +ATOM 68 CB PHE A 9 28.867 68.393 56.869 1.00 8.50 C +ATOM 69 CG PHE A 9 28.723 69.696 57.577 1.00 11.60 C +ATOM 70 CD1 PHE A 9 29.634 70.078 58.551 1.00 13.81 C +ATOM 71 CD2 PHE A 9 27.636 70.526 57.313 1.00 8.50 C +ATOM 72 CE1 PHE A 9 29.455 71.276 59.256 1.00 14.01 C +ATOM 73 CE2 PHE A 9 27.460 71.709 58.009 1.00 8.50 C +ATOM 74 CZ PHE A 9 28.368 72.086 58.980 1.00 8.50 C +ATOM 75 N VAL A 10 31.026 65.941 56.056 1.00 9.78 N +ATOM 76 CA VAL A 10 31.111 64.594 55.535 1.00 9.43 C +ATOM 77 C VAL A 10 30.865 63.516 56.601 1.00 11.58 C +ATOM 78 O VAL A 10 31.547 63.490 57.623 1.00 15.47 O +ATOM 79 CB VAL A 10 32.446 64.391 54.744 1.00 8.57 C +ATOM 80 CG1 VAL A 10 33.539 65.272 55.295 1.00 8.50 C +ATOM 81 CG2 VAL A 10 32.872 62.930 54.735 1.00 8.50 C +ATOM 82 N PHE A 11 29.832 62.697 56.379 1.00 8.63 N +ATOM 83 CA PHE A 11 29.428 61.584 57.250 1.00 8.50 C +ATOM 84 C PHE A 11 29.958 60.313 56.586 1.00 10.80 C +ATOM 85 O PHE A 11 29.268 59.710 55.755 1.00 11.08 O +ATOM 86 CB PHE A 11 27.904 61.517 57.309 1.00 8.50 C +ATOM 87 CG PHE A 11 27.255 62.820 57.691 1.00 15.41 C +ATOM 88 CD1 PHE A 11 27.053 63.154 59.029 1.00 18.51 C +ATOM 89 CD2 PHE A 11 26.841 63.714 56.716 1.00 12.18 C +ATOM 90 CE1 PHE A 11 26.450 64.352 59.387 1.00 11.30 C +ATOM 91 CE2 PHE A 11 26.238 64.912 57.067 1.00 11.21 C +ATOM 92 CZ PHE A 11 26.042 65.228 58.407 1.00 12.21 C +ATOM 93 N PRO A 12 31.177 59.872 56.964 1.00 11.44 N +ATOM 94 CA PRO A 12 31.859 58.686 56.425 1.00 12.40 C +ATOM 95 C PRO A 12 31.213 57.333 56.610 1.00 20.30 C +ATOM 96 O PRO A 12 31.436 56.440 55.794 1.00 27.66 O +ATOM 97 CB PRO A 12 33.233 58.730 57.094 1.00 8.50 C +ATOM 98 CG PRO A 12 33.387 60.145 57.493 1.00 9.72 C +ATOM 99 CD PRO A 12 32.018 60.495 57.993 1.00 10.37 C +ATOM 100 N LYS A 13 30.482 57.138 57.706 1.00 31.31 N +ATOM 101 CA LYS A 13 29.837 55.842 57.934 1.00 35.39 C +ATOM 102 C LYS A 13 28.433 55.886 58.494 1.00 34.35 C +ATOM 103 O LYS A 13 28.028 56.884 59.107 1.00 32.46 O +ATOM 104 CB LYS A 13 30.720 54.895 58.761 1.00 41.31 C +ATOM 105 CG LYS A 13 31.396 55.493 59.989 1.00 46.44 C +ATOM 106 CD LYS A 13 32.413 54.477 60.541 1.00 60.69 C +ATOM 107 CE LYS A 13 33.258 55.043 61.685 1.00 66.75 C +ATOM 108 NZ LYS A 13 32.448 55.388 62.902 1.00 71.07 N +ATOM 109 N GLU A 14 27.701 54.797 58.249 1.00 34.43 N +ATOM 110 CA GLU A 14 26.320 54.659 58.689 1.00 41.25 C +ATOM 111 C GLU A 14 26.243 54.766 60.202 1.00 44.19 C +ATOM 112 O GLU A 14 26.872 53.992 60.929 1.00 46.47 O +ATOM 113 CB GLU A 14 25.722 53.328 58.212 1.00 39.39 C +ATOM 114 CG GLU A 14 24.210 53.230 58.453 1.00 45.42 C +ATOM 115 CD GLU A 14 23.590 51.977 57.872 1.00 43.67 C +ATOM 116 OE1 GLU A 14 23.599 51.819 56.632 1.00 51.32 O +ATOM 117 OE2 GLU A 14 23.073 51.159 58.654 1.00 43.60 O +ATOM 118 N SER A 15 25.491 55.750 60.675 1.00 45.79 N +ATOM 119 CA SER A 15 25.365 55.966 62.100 1.00 42.66 C +ATOM 120 C SER A 15 23.944 56.156 62.564 1.00 41.32 C +ATOM 121 O SER A 15 22.996 56.209 61.777 1.00 38.01 O +ATOM 122 CB SER A 15 26.250 57.138 62.550 1.00 46.46 C +ATOM 123 OG SER A 15 26.057 58.293 61.746 1.00 60.41 O +ATOM 124 N ASP A 16 23.829 56.208 63.878 1.00 45.06 N +ATOM 125 CA ASP A 16 22.575 56.365 64.593 1.00 46.36 C +ATOM 126 C ASP A 16 22.750 57.660 65.390 1.00 41.70 C +ATOM 127 O ASP A 16 21.776 58.290 65.793 1.00 38.31 O +ATOM 128 CB ASP A 16 22.469 55.168 65.556 1.00 58.18 C +ATOM 129 CG ASP A 16 21.046 54.831 65.954 1.00 68.27 C +ATOM 130 OD1 ASP A 16 20.104 55.167 65.208 1.00 74.34 O +ATOM 131 OD2 ASP A 16 20.880 54.189 67.015 1.00 68.27 O +ATOM 132 N THR A 17 24.013 58.075 65.517 1.00 39.99 N +ATOM 133 CA THR A 17 24.431 59.236 66.298 1.00 38.55 C +ATOM 134 C THR A 17 24.976 60.504 65.602 1.00 41.42 C +ATOM 135 O THR A 17 25.012 61.578 66.218 1.00 44.99 O +ATOM 136 CB THR A 17 25.499 58.779 67.291 1.00 34.53 C +ATOM 137 OG1 THR A 17 26.506 58.024 66.599 1.00 40.11 O +ATOM 138 CG2 THR A 17 24.878 57.883 68.335 1.00 50.46 C +ATOM 139 N SER A 18 25.438 60.385 64.360 1.00 35.09 N +ATOM 140 CA SER A 18 26.002 61.525 63.657 1.00 19.79 C +ATOM 141 C SER A 18 24.964 62.422 63.010 1.00 18.91 C +ATOM 142 O SER A 18 24.021 61.938 62.370 1.00 14.01 O +ATOM 143 CB SER A 18 27.018 61.057 62.606 1.00 20.61 C +ATOM 144 OG SER A 18 28.030 60.240 63.176 1.00 8.50 O +ATOM 145 N TYR A 19 25.145 63.734 63.202 1.00 17.97 N +ATOM 146 CA TYR A 19 24.277 64.772 62.630 1.00 14.30 C +ATOM 147 C TYR A 19 24.834 66.146 62.916 1.00 12.92 C +ATOM 148 O TYR A 19 25.738 66.288 63.742 1.00 12.98 O +ATOM 149 CB TYR A 19 22.841 64.679 63.152 1.00 14.87 C +ATOM 150 CG TYR A 19 22.659 65.035 64.603 1.00 25.07 C +ATOM 151 CD1 TYR A 19 22.418 66.345 64.982 1.00 27.61 C +ATOM 152 CD2 TYR A 19 22.712 64.057 65.603 1.00 34.96 C +ATOM 153 CE1 TYR A 19 22.233 66.689 66.316 1.00 31.95 C +ATOM 154 CE2 TYR A 19 22.525 64.387 66.948 1.00 36.03 C +ATOM 155 CZ TYR A 19 22.286 65.710 67.295 1.00 35.99 C +ATOM 156 OH TYR A 19 22.092 66.060 68.614 1.00 44.49 O +ATOM 157 N VAL A 20 24.322 67.146 62.198 1.00 16.47 N +ATOM 158 CA VAL A 20 24.744 68.543 62.370 1.00 12.12 C +ATOM 159 C VAL A 20 23.482 69.354 62.536 1.00 15.82 C +ATOM 160 O VAL A 20 22.558 69.251 61.719 1.00 16.95 O +ATOM 161 CB VAL A 20 25.495 69.093 61.149 1.00 8.50 C +ATOM 162 CG1 VAL A 20 25.815 70.548 61.360 1.00 8.50 C +ATOM 163 CG2 VAL A 20 26.768 68.320 60.930 1.00 17.38 C +ATOM 164 N SER A 21 23.423 70.113 63.621 1.00 17.72 N +ATOM 165 CA SER A 21 22.271 70.944 63.910 1.00 17.74 C +ATOM 166 C SER A 21 22.534 72.361 63.422 1.00 16.28 C +ATOM 167 O SER A 21 23.591 72.946 63.687 1.00 14.60 O +ATOM 168 CB SER A 21 21.997 70.954 65.407 1.00 29.09 C +ATOM 169 OG SER A 21 20.845 71.723 65.715 1.00 43.70 O +ATOM 170 N LEU A 22 21.569 72.899 62.685 1.00 15.79 N +ATOM 171 CA LEU A 22 21.656 74.250 62.139 1.00 13.77 C +ATOM 172 C LEU A 22 20.744 75.157 62.942 1.00 19.14 C +ATOM 173 O LEU A 22 19.573 74.838 63.163 1.00 21.45 O +ATOM 174 CB LEU A 22 21.240 74.253 60.669 1.00 9.56 C +ATOM 175 CG LEU A 22 22.340 74.155 59.602 1.00 14.76 C +ATOM 176 CD1 LEU A 22 23.473 73.218 59.987 1.00 8.50 C +ATOM 177 CD2 LEU A 22 21.702 73.719 58.306 1.00 9.07 C +ATOM 178 N LYS A 23 21.298 76.280 63.387 1.00 27.41 N +ATOM 179 CA LYS A 23 20.578 77.261 64.199 1.00 32.01 C +ATOM 180 C LYS A 23 20.120 78.437 63.355 1.00 35.04 C +ATOM 181 O LYS A 23 20.945 79.203 62.846 1.00 35.72 O +ATOM 182 CB LYS A 23 21.507 77.766 65.323 1.00 40.65 C +ATOM 183 CG LYS A 23 20.878 78.701 66.373 1.00 46.88 C +ATOM 184 CD LYS A 23 21.841 78.931 67.576 1.00 59.05 C +ATOM 185 CE LYS A 23 21.894 77.738 68.588 1.00 47.79 C +ATOM 186 NZ LYS A 23 22.983 77.852 69.638 1.00 8.50 N +ATOM 187 N ALA A 24 18.808 78.574 63.206 1.00 43.31 N +ATOM 188 CA ALA A 24 18.235 79.662 62.433 1.00 53.97 C +ATOM 189 C ALA A 24 17.556 80.629 63.384 1.00 65.77 C +ATOM 190 O ALA A 24 16.807 80.206 64.269 1.00 71.55 O +ATOM 191 CB ALA A 24 17.224 79.116 61.449 1.00 55.36 C +ATOM 192 N PRO A 25 17.851 81.934 63.256 1.00 73.18 N +ATOM 193 CA PRO A 25 17.251 82.961 64.115 1.00 78.50 C +ATOM 194 C PRO A 25 15.901 83.403 63.554 1.00 80.46 C +ATOM 195 O PRO A 25 15.723 84.545 63.121 1.00 80.25 O +ATOM 196 CB PRO A 25 18.284 84.082 64.065 1.00 82.02 C +ATOM 197 CG PRO A 25 18.789 83.990 62.664 1.00 77.57 C +ATOM 198 CD PRO A 25 18.942 82.498 62.442 1.00 74.45 C +ATOM 199 N LEU A 26 14.950 82.481 63.571 1.00 81.66 N +ATOM 200 CA LEU A 26 13.620 82.740 63.057 1.00 82.17 C +ATOM 201 C LEU A 26 12.688 83.319 64.124 1.00 85.35 C +ATOM 202 O LEU A 26 12.689 82.886 65.284 1.00 83.49 O +ATOM 203 CB LEU A 26 13.046 81.453 62.465 1.00 80.19 C +ATOM 204 CG LEU A 26 12.405 81.532 61.078 1.00 75.26 C +ATOM 205 CD1 LEU A 26 13.166 82.496 60.174 1.00 76.80 C +ATOM 206 CD2 LEU A 26 12.370 80.143 60.469 1.00 71.14 C +ATOM 207 N THR A 27 11.922 84.328 63.715 1.00 88.74 N +ATOM 208 CA THR A 27 10.969 85.013 64.586 1.00 88.21 C +ATOM 209 C THR A 27 9.542 84.882 64.042 1.00 82.04 C +ATOM 210 O THR A 27 8.607 84.581 64.786 1.00 83.17 O +ATOM 211 CB THR A 27 11.315 86.514 64.718 1.00 89.55 C +ATOM 212 OG1 THR A 27 11.522 87.072 63.413 1.00 91.07 O +ATOM 213 CG2 THR A 27 12.567 86.706 65.564 1.00 92.46 C +ATOM 214 N LYS A 28 9.383 85.149 62.751 1.00 74.17 N +ATOM 215 CA LYS A 28 8.086 85.058 62.091 1.00 70.12 C +ATOM 216 C LYS A 28 7.913 83.671 61.494 1.00 60.36 C +ATOM 217 O LYS A 28 8.888 83.061 61.057 1.00 66.92 O +ATOM 218 CB LYS A 28 7.995 86.086 60.951 1.00 83.43 C +ATOM 219 CG LYS A 28 7.705 87.525 61.374 1.00 92.49 C +ATOM 220 CD LYS A 28 6.237 87.716 61.739 1.00 98.34 C +ATOM 221 CE LYS A 28 5.943 89.162 62.111 1.00100.03 C +ATOM 222 NZ LYS A 28 4.493 89.368 62.379 1.00103.31 N +ATOM 223 N PRO A 29 6.690 83.119 61.544 1.00 47.74 N +ATOM 224 CA PRO A 29 6.442 81.790 60.974 1.00 44.07 C +ATOM 225 C PRO A 29 6.476 81.876 59.427 1.00 40.07 C +ATOM 226 O PRO A 29 6.094 82.901 58.845 1.00 42.10 O +ATOM 227 CB PRO A 29 5.053 81.437 61.530 1.00 42.65 C +ATOM 228 CG PRO A 29 4.407 82.763 61.704 1.00 44.42 C +ATOM 229 CD PRO A 29 5.515 83.595 62.292 1.00 43.48 C +ATOM 230 N LEU A 30 6.946 80.820 58.766 1.00 29.43 N +ATOM 231 CA LEU A 30 7.056 80.818 57.314 1.00 20.08 C +ATOM 232 C LEU A 30 5.753 80.636 56.523 1.00 21.31 C +ATOM 233 O LEU A 30 4.960 79.714 56.779 1.00 15.69 O +ATOM 234 CB LEU A 30 8.076 79.776 56.849 1.00 8.53 C +ATOM 235 CG LEU A 30 9.567 79.889 57.158 1.00 8.50 C +ATOM 236 CD1 LEU A 30 9.943 81.282 57.536 1.00 8.50 C +ATOM 237 CD2 LEU A 30 9.925 78.939 58.269 1.00 16.87 C +ATOM 238 N LYS A 31 5.571 81.507 55.529 1.00 22.00 N +ATOM 239 CA LYS A 31 4.411 81.489 54.621 1.00 19.48 C +ATOM 240 C LYS A 31 4.866 81.071 53.218 1.00 18.51 C +ATOM 241 O LYS A 31 4.053 80.976 52.285 1.00 13.77 O +ATOM 242 CB LYS A 31 3.771 82.879 54.551 1.00 27.83 C +ATOM 243 CG LYS A 31 2.882 83.212 55.740 1.00 51.09 C +ATOM 244 CD LYS A 31 1.635 82.326 55.737 1.00 65.15 C +ATOM 245 CE LYS A 31 0.741 82.573 56.952 1.00 69.05 C +ATOM 246 NZ LYS A 31 -0.474 81.696 56.920 1.00 77.22 N +ATOM 247 N ALA A 32 6.180 80.866 53.090 1.00 18.53 N +ATOM 248 CA ALA A 32 6.853 80.452 51.859 1.00 12.06 C +ATOM 249 C ALA A 32 8.323 80.233 52.211 1.00 12.23 C +ATOM 250 O ALA A 32 8.760 80.631 53.291 1.00 18.34 O +ATOM 251 CB ALA A 32 6.737 81.525 50.824 1.00 18.07 C +ATOM 252 N PHE A 33 9.082 79.579 51.336 1.00 8.50 N +ATOM 253 CA PHE A 33 10.503 79.352 51.600 1.00 8.50 C +ATOM 254 C PHE A 33 11.167 78.703 50.401 1.00 8.50 C +ATOM 255 O PHE A 33 10.487 78.185 49.525 1.00 13.28 O +ATOM 256 CB PHE A 33 10.698 78.482 52.856 1.00 8.50 C +ATOM 257 CG PHE A 33 10.139 77.059 52.728 1.00 22.31 C +ATOM 258 CD1 PHE A 33 10.920 76.028 52.204 1.00 21.71 C +ATOM 259 CD2 PHE A 33 8.838 76.750 53.135 1.00 16.00 C +ATOM 260 CE1 PHE A 33 10.416 74.743 52.094 1.00 10.48 C +ATOM 261 CE2 PHE A 33 8.340 75.460 53.022 1.00 8.50 C +ATOM 262 CZ PHE A 33 9.124 74.465 52.505 1.00 8.50 C +ATOM 263 N THR A 34 12.488 78.779 50.347 1.00 8.50 N +ATOM 264 CA THR A 34 13.279 78.170 49.283 1.00 8.50 C +ATOM 265 C THR A 34 14.495 77.648 50.003 1.00 10.26 C +ATOM 266 O THR A 34 15.113 78.378 50.787 1.00 12.07 O +ATOM 267 CB THR A 34 13.807 79.197 48.235 1.00 8.50 C +ATOM 268 OG1 THR A 34 12.720 79.915 47.650 1.00 11.61 O +ATOM 269 CG2 THR A 34 14.567 78.501 47.134 1.00 8.50 C +ATOM 270 N VAL A 35 14.814 76.381 49.797 1.00 8.50 N +ATOM 271 CA VAL A 35 15.999 75.819 50.414 1.00 8.97 C +ATOM 272 C VAL A 35 16.776 75.104 49.329 1.00 8.50 C +ATOM 273 O VAL A 35 16.204 74.338 48.553 1.00 11.38 O +ATOM 274 CB VAL A 35 15.658 74.911 51.616 1.00 8.50 C +ATOM 275 CG1 VAL A 35 14.209 74.467 51.567 1.00 8.50 C +ATOM 276 CG2 VAL A 35 16.600 73.710 51.656 1.00 16.04 C +ATOM 277 N CYS A 36 18.047 75.455 49.209 1.00 8.50 N +ATOM 278 CA CYS A 36 18.924 74.871 48.206 1.00 9.44 C +ATOM 279 C CYS A 36 20.081 74.207 48.928 1.00 9.64 C +ATOM 280 O CYS A 36 20.447 74.635 50.022 1.00 13.85 O +ATOM 281 CB CYS A 36 19.464 75.965 47.270 1.00 8.50 C +ATOM 282 SG CYS A 36 18.202 76.886 46.321 1.00 10.94 S +ATOM 283 N LEU A 37 20.630 73.150 48.341 1.00 8.50 N +ATOM 284 CA LEU A 37 21.760 72.443 48.935 1.00 12.53 C +ATOM 285 C LEU A 37 22.446 71.528 47.919 1.00 11.20 C +ATOM 286 O LEU A 37 21.906 71.255 46.839 1.00 8.50 O +ATOM 287 CB LEU A 37 21.315 71.654 50.171 1.00 17.51 C +ATOM 288 CG LEU A 37 20.249 70.567 50.036 1.00 15.01 C +ATOM 289 CD1 LEU A 37 20.911 69.237 49.720 1.00 15.18 C +ATOM 290 CD2 LEU A 37 19.496 70.469 51.349 1.00 14.66 C +ATOM 291 N HIS A 38 23.647 71.087 48.268 1.00 8.50 N +ATOM 292 CA HIS A 38 24.452 70.224 47.424 1.00 11.48 C +ATOM 293 C HIS A 38 24.715 68.964 48.247 1.00 15.36 C +ATOM 294 O HIS A 38 25.109 69.071 49.406 1.00 20.29 O +ATOM 295 CB HIS A 38 25.797 70.906 47.178 1.00 17.96 C +ATOM 296 CG HIS A 38 26.104 71.184 45.735 1.00 22.12 C +ATOM 297 ND1 HIS A 38 26.360 72.457 45.266 1.00 18.35 N +ATOM 298 CD2 HIS A 38 26.286 70.352 44.680 1.00 19.65 C +ATOM 299 CE1 HIS A 38 26.690 72.396 43.988 1.00 17.92 C +ATOM 300 NE2 HIS A 38 26.655 71.131 43.609 1.00 17.68 N +ATOM 301 N PHE A 39 24.492 67.780 47.680 1.00 14.27 N +ATOM 302 CA PHE A 39 24.760 66.556 48.424 1.00 9.82 C +ATOM 303 C PHE A 39 25.375 65.551 47.486 1.00 8.50 C +ATOM 304 O PHE A 39 25.266 65.684 46.280 1.00 12.60 O +ATOM 305 CB PHE A 39 23.498 66.026 49.110 1.00 8.50 C +ATOM 306 CG PHE A 39 22.503 65.400 48.187 1.00 8.50 C +ATOM 307 CD1 PHE A 39 21.533 66.163 47.574 1.00 8.50 C +ATOM 308 CD2 PHE A 39 22.517 64.023 47.967 1.00 10.73 C +ATOM 309 CE1 PHE A 39 20.586 65.581 46.758 1.00 8.50 C +ATOM 310 CE2 PHE A 39 21.576 63.426 47.153 1.00 13.03 C +ATOM 311 CZ PHE A 39 20.601 64.211 46.544 1.00 12.91 C +ATOM 312 N TYR A 40 26.065 64.573 48.033 1.00 8.50 N +ATOM 313 CA TYR A 40 26.724 63.581 47.212 1.00 10.52 C +ATOM 314 C TYR A 40 26.802 62.274 47.991 1.00 11.81 C +ATOM 315 O TYR A 40 27.597 62.152 48.923 1.00 10.47 O +ATOM 316 CB TYR A 40 28.139 64.082 46.864 1.00 8.50 C +ATOM 317 CG TYR A 40 28.930 63.146 45.995 1.00 8.50 C +ATOM 318 CD1 TYR A 40 28.285 62.229 45.159 1.00 8.50 C +ATOM 319 CD2 TYR A 40 30.316 63.183 45.986 1.00 8.50 C +ATOM 320 CE1 TYR A 40 28.998 61.379 44.336 1.00 8.50 C +ATOM 321 CE2 TYR A 40 31.046 62.330 45.155 1.00 8.50 C +ATOM 322 CZ TYR A 40 30.374 61.434 44.334 1.00 8.50 C +ATOM 323 OH TYR A 40 31.062 60.602 43.489 1.00 11.26 O +ATOM 324 N THR A 41 26.002 61.291 47.595 1.00 13.23 N +ATOM 325 CA THR A 41 25.990 60.000 48.287 1.00 12.51 C +ATOM 326 C THR A 41 25.880 58.822 47.334 1.00 17.24 C +ATOM 327 O THR A 41 25.515 58.988 46.170 1.00 18.98 O +ATOM 328 CB THR A 41 24.828 59.911 49.281 1.00 14.87 C +ATOM 329 OG1 THR A 41 24.917 58.679 50.006 1.00 15.08 O +ATOM 330 CG2 THR A 41 23.468 59.986 48.544 1.00 8.52 C +ATOM 331 N GLU A 42 26.123 57.623 47.855 1.00 20.64 N +ATOM 332 CA GLU A 42 26.072 56.408 47.047 1.00 25.67 C +ATOM 333 C GLU A 42 24.923 55.492 47.476 1.00 26.39 C +ATOM 334 O GLU A 42 24.829 54.352 47.044 1.00 33.02 O +ATOM 335 CB GLU A 42 27.401 55.671 47.188 1.00 33.54 C +ATOM 336 CG GLU A 42 27.944 55.035 45.913 1.00 44.44 C +ATOM 337 CD GLU A 42 29.425 54.667 46.031 1.00 53.37 C +ATOM 338 OE1 GLU A 42 29.739 53.559 46.531 1.00 57.32 O +ATOM 339 OE2 GLU A 42 30.277 55.499 45.632 1.00 53.15 O +ATOM 340 N LEU A 43 24.130 55.957 48.437 1.00 21.79 N +ATOM 341 CA LEU A 43 23.005 55.184 48.968 1.00 17.12 C +ATOM 342 C LEU A 43 21.840 55.002 48.021 1.00 15.58 C +ATOM 343 O LEU A 43 21.154 54.000 48.085 1.00 21.02 O +ATOM 344 CB LEU A 43 22.466 55.827 50.246 1.00 19.78 C +ATOM 345 CG LEU A 43 23.048 55.550 51.635 1.00 25.64 C +ATOM 346 CD1 LEU A 43 24.527 55.201 51.588 1.00 22.47 C +ATOM 347 CD2 LEU A 43 22.814 56.788 52.493 1.00 27.84 C +ATOM 348 N SER A 44 21.586 56.001 47.192 1.00 20.53 N +ATOM 349 CA SER A 44 20.473 56.011 46.238 1.00 24.27 C +ATOM 350 C SER A 44 20.018 54.659 45.668 1.00 30.81 C +ATOM 351 O SER A 44 18.817 54.429 45.450 1.00 26.38 O +ATOM 352 CB SER A 44 20.820 56.943 45.074 1.00 31.65 C +ATOM 353 OG SER A 44 21.339 58.184 45.524 1.00 39.73 O +ATOM 354 N SER A 45 20.984 53.775 45.426 1.00 37.79 N +ATOM 355 CA SER A 45 20.728 52.456 44.846 1.00 44.82 C +ATOM 356 C SER A 45 20.334 51.338 45.819 1.00 43.65 C +ATOM 357 O SER A 45 19.910 50.263 45.385 1.00 50.55 O +ATOM 358 CB SER A 45 21.956 52.004 44.043 1.00 51.41 C +ATOM 359 OG SER A 45 22.432 53.041 43.195 1.00 68.63 O +ATOM 360 N THR A 46 20.482 51.571 47.120 1.00 37.47 N +ATOM 361 CA THR A 46 20.158 50.548 48.106 1.00 30.59 C +ATOM 362 C THR A 46 19.094 50.921 49.162 1.00 31.45 C +ATOM 363 O THR A 46 18.185 50.121 49.429 1.00 40.93 O +ATOM 364 CB THR A 46 21.453 50.022 48.805 1.00 34.48 C +ATOM 365 OG1 THR A 46 21.835 50.908 49.865 1.00 45.55 O +ATOM 366 CG2 THR A 46 22.619 49.927 47.803 1.00 27.43 C +ATOM 367 N ARG A 47 19.201 52.097 49.783 1.00 24.33 N +ATOM 368 CA ARG A 47 18.211 52.487 50.789 1.00 21.49 C +ATOM 369 C ARG A 47 17.769 53.949 50.666 1.00 19.80 C +ATOM 370 O ARG A 47 18.246 54.668 49.783 1.00 22.49 O +ATOM 371 CB ARG A 47 18.718 52.184 52.202 1.00 8.50 C +ATOM 372 CG ARG A 47 19.837 53.072 52.667 1.00 12.98 C +ATOM 373 CD ARG A 47 20.181 52.761 54.113 1.00 21.23 C +ATOM 374 NE ARG A 47 21.320 53.530 54.630 1.00 10.45 N +ATOM 375 CZ ARG A 47 21.217 54.720 55.207 1.00 8.50 C +ATOM 376 NH1 ARG A 47 20.031 55.299 55.332 1.00 9.21 N +ATOM 377 NH2 ARG A 47 22.280 55.271 55.767 1.00 10.54 N +ATOM 378 N GLY A 48 16.804 54.349 51.503 1.00 17.21 N +ATOM 379 CA GLY A 48 16.311 55.714 51.513 1.00 13.17 C +ATOM 380 C GLY A 48 17.146 56.496 52.513 1.00 16.15 C +ATOM 381 O GLY A 48 17.818 55.884 53.336 1.00 22.29 O +ATOM 382 N TYR A 49 17.122 57.826 52.458 1.00 13.90 N +ATOM 383 CA TYR A 49 17.907 58.648 53.387 1.00 12.99 C +ATOM 384 C TYR A 49 17.357 60.071 53.507 1.00 16.74 C +ATOM 385 O TYR A 49 16.668 60.573 52.606 1.00 20.89 O +ATOM 386 CB TYR A 49 19.384 58.687 52.964 1.00 10.49 C +ATOM 387 CG TYR A 49 19.591 59.037 51.506 1.00 19.01 C +ATOM 388 CD1 TYR A 49 19.540 60.355 51.074 1.00 28.28 C +ATOM 389 CD2 TYR A 49 19.841 58.054 50.557 1.00 16.91 C +ATOM 390 CE1 TYR A 49 19.735 60.686 49.734 1.00 27.44 C +ATOM 391 CE2 TYR A 49 20.040 58.383 49.218 1.00 21.26 C +ATOM 392 CZ TYR A 49 19.990 59.699 48.818 1.00 11.46 C +ATOM 393 OH TYR A 49 20.239 60.027 47.512 1.00 8.50 O +ATOM 394 N SER A 50 17.659 60.719 54.621 1.00 14.94 N +ATOM 395 CA SER A 50 17.185 62.067 54.846 1.00 20.93 C +ATOM 396 C SER A 50 18.219 63.097 54.406 1.00 25.00 C +ATOM 397 O SER A 50 19.401 63.044 54.783 1.00 28.83 O +ATOM 398 CB SER A 50 16.834 62.271 56.323 1.00 26.54 C +ATOM 399 OG SER A 50 16.477 63.625 56.591 1.00 31.03 O +ATOM 400 N ILE A 51 17.755 64.049 53.612 1.00 24.72 N +ATOM 401 CA ILE A 51 18.613 65.112 53.114 1.00 19.48 C +ATOM 402 C ILE A 51 18.518 66.360 54.003 1.00 19.98 C +ATOM 403 O ILE A 51 19.539 66.846 54.501 1.00 21.71 O +ATOM 404 CB ILE A 51 18.244 65.463 51.641 1.00 12.12 C +ATOM 405 CG1 ILE A 51 18.456 64.237 50.753 1.00 12.78 C +ATOM 406 CG2 ILE A 51 19.103 66.596 51.140 1.00 11.99 C +ATOM 407 CD1 ILE A 51 17.993 64.409 49.340 1.00 16.07 C +ATOM 408 N PHE A 52 17.291 66.836 54.228 1.00 14.19 N +ATOM 409 CA PHE A 52 17.051 68.032 55.028 1.00 11.80 C +ATOM 410 C PHE A 52 15.824 67.786 55.918 1.00 18.41 C +ATOM 411 O PHE A 52 14.736 67.485 55.404 1.00 15.04 O +ATOM 412 CB PHE A 52 16.786 69.210 54.081 1.00 10.44 C +ATOM 413 CG PHE A 52 16.708 70.548 54.759 1.00 10.38 C +ATOM 414 CD1 PHE A 52 17.852 71.177 55.218 1.00 8.50 C +ATOM 415 CD2 PHE A 52 15.486 71.191 54.912 1.00 10.01 C +ATOM 416 CE1 PHE A 52 17.780 72.420 55.814 1.00 8.50 C +ATOM 417 CE2 PHE A 52 15.406 72.439 55.510 1.00 8.50 C +ATOM 418 CZ PHE A 52 16.554 73.052 55.959 1.00 10.36 C +ATOM 419 N SER A 53 15.995 67.931 57.238 1.00 21.38 N +ATOM 420 CA SER A 53 14.903 67.719 58.206 1.00 17.05 C +ATOM 421 C SER A 53 14.623 68.941 59.103 1.00 12.97 C +ATOM 422 O SER A 53 15.390 69.252 60.016 1.00 11.49 O +ATOM 423 CB SER A 53 15.203 66.494 59.089 1.00 20.83 C +ATOM 424 OG SER A 53 14.066 66.100 59.850 1.00 14.27 O +ATOM 425 N TYR A 54 13.509 69.612 58.842 1.00 10.70 N +ATOM 426 CA TYR A 54 13.098 70.785 59.601 1.00 14.81 C +ATOM 427 C TYR A 54 11.923 70.345 60.473 1.00 24.13 C +ATOM 428 O TYR A 54 10.822 70.101 59.960 1.00 28.58 O +ATOM 429 CB TYR A 54 12.657 71.872 58.619 1.00 16.78 C +ATOM 430 CG TYR A 54 12.302 73.226 59.212 1.00 17.36 C +ATOM 431 CD1 TYR A 54 11.001 73.496 59.668 1.00 15.70 C +ATOM 432 CD2 TYR A 54 13.229 74.260 59.224 1.00 8.50 C +ATOM 433 CE1 TYR A 54 10.638 74.754 60.105 1.00 9.27 C +ATOM 434 CE2 TYR A 54 12.876 75.515 59.662 1.00 11.47 C +ATOM 435 CZ TYR A 54 11.581 75.759 60.099 1.00 14.39 C +ATOM 436 OH TYR A 54 11.224 77.013 60.531 1.00 18.14 O +ATOM 437 N ALA A 55 12.143 70.277 61.783 1.00 27.94 N +ATOM 438 CA ALA A 55 11.108 69.830 62.705 1.00 32.17 C +ATOM 439 C ALA A 55 10.658 70.838 63.751 1.00 35.07 C +ATOM 440 O ALA A 55 11.453 71.652 64.215 1.00 35.76 O +ATOM 441 CB ALA A 55 11.569 68.561 63.391 1.00 36.12 C +ATOM 442 N THR A 56 9.390 70.724 64.155 1.00 38.88 N +ATOM 443 CA THR A 56 8.770 71.579 65.170 1.00 41.66 C +ATOM 444 C THR A 56 8.339 70.672 66.318 1.00 45.12 C +ATOM 445 O THR A 56 8.267 69.453 66.163 1.00 43.41 O +ATOM 446 CB THR A 56 7.473 72.261 64.653 1.00 42.07 C +ATOM 447 OG1 THR A 56 7.644 72.698 63.296 1.00 41.25 O +ATOM 448 CG2 THR A 56 7.122 73.463 65.540 1.00 45.35 C +ATOM 449 N LYS A 57 8.026 71.275 67.461 1.00 50.74 N +ATOM 450 CA LYS A 57 7.579 70.506 68.614 1.00 50.41 C +ATOM 451 C LYS A 57 6.257 69.836 68.283 1.00 48.09 C +ATOM 452 O LYS A 57 6.063 68.664 68.581 1.00 53.07 O +ATOM 453 CB LYS A 57 7.490 71.359 69.885 1.00 62.11 C +ATOM 454 CG LYS A 57 7.661 72.878 69.685 1.00 72.83 C +ATOM 455 CD LYS A 57 7.943 73.616 71.010 1.00 70.21 C +ATOM 456 CE LYS A 57 9.354 73.330 71.550 1.00 73.34 C +ATOM 457 NZ LYS A 57 10.417 73.738 70.583 1.00 73.77 N +ATOM 458 N ARG A 58 5.392 70.565 67.583 1.00 47.55 N +ATOM 459 CA ARG A 58 4.075 70.055 67.176 1.00 47.87 C +ATOM 460 C ARG A 58 4.104 69.104 65.970 1.00 45.25 C +ATOM 461 O ARG A 58 3.336 68.139 65.918 1.00 43.13 O +ATOM 462 CB ARG A 58 3.063 71.200 66.954 1.00 58.43 C +ATOM 463 CG ARG A 58 2.581 71.488 65.514 1.00 55.65 C +ATOM 464 CD ARG A 58 3.501 72.439 64.715 1.00 75.72 C +ATOM 465 NE ARG A 58 4.138 73.486 65.523 1.00 86.85 N +ATOM 466 CZ ARG A 58 3.960 74.799 65.373 1.00 96.84 C +ATOM 467 NH1 ARG A 58 3.140 75.281 64.443 1.00 98.89 N +ATOM 468 NH2 ARG A 58 4.672 75.638 66.116 1.00102.72 N +ATOM 469 N GLN A 59 5.000 69.362 65.019 1.00 40.81 N +ATOM 470 CA GLN A 59 5.110 68.538 63.822 1.00 31.23 C +ATOM 471 C GLN A 59 6.569 68.204 63.572 1.00 29.87 C +ATOM 472 O GLN A 59 7.367 69.084 63.279 1.00 35.17 O +ATOM 473 CB GLN A 59 4.504 69.303 62.636 1.00 30.78 C +ATOM 474 CG GLN A 59 4.721 68.708 61.262 1.00 25.69 C +ATOM 475 CD GLN A 59 4.175 67.326 61.145 1.00 21.52 C +ATOM 476 OE1 GLN A 59 4.827 66.362 61.533 1.00 25.93 O +ATOM 477 NE2 GLN A 59 2.983 67.210 60.599 1.00 19.21 N +ATOM 478 N ASP A 60 6.912 66.927 63.678 1.00 30.98 N +ATOM 479 CA ASP A 60 8.298 66.476 63.483 1.00 30.77 C +ATOM 480 C ASP A 60 8.788 66.593 62.040 1.00 26.27 C +ATOM 481 O ASP A 60 9.989 66.717 61.787 1.00 28.05 O +ATOM 482 CB ASP A 60 8.491 65.034 63.990 1.00 38.02 C +ATOM 483 CG ASP A 60 7.600 64.017 63.269 1.00 37.05 C +ATOM 484 OD1 ASP A 60 6.369 64.217 63.204 1.00 41.82 O +ATOM 485 OD2 ASP A 60 8.141 62.999 62.791 1.00 36.18 O +ATOM 486 N ASN A 61 7.864 66.536 61.089 1.00 19.44 N +ATOM 487 CA ASN A 61 8.232 66.642 59.682 1.00 12.67 C +ATOM 488 C ASN A 61 7.588 67.886 59.080 1.00 14.03 C +ATOM 489 O ASN A 61 6.717 67.788 58.201 1.00 12.97 O +ATOM 490 CB ASN A 61 7.793 65.390 58.917 1.00 8.50 C +ATOM 491 CG ASN A 61 8.547 64.159 59.346 1.00 26.22 C +ATOM 492 OD1 ASN A 61 8.049 63.048 59.201 1.00 34.97 O +ATOM 493 ND2 ASN A 61 9.758 64.344 59.890 1.00 40.55 N +ATOM 494 N GLU A 62 7.992 69.055 59.586 1.00 12.79 N +ATOM 495 CA GLU A 62 7.456 70.333 59.124 1.00 11.03 C +ATOM 496 C GLU A 62 7.829 70.569 57.662 1.00 11.85 C +ATOM 497 O GLU A 62 7.013 71.025 56.865 1.00 17.33 O +ATOM 498 CB GLU A 62 7.935 71.472 60.026 1.00 10.81 C +ATOM 499 CG GLU A 62 7.164 72.785 59.871 1.00 14.31 C +ATOM 500 CD GLU A 62 5.719 72.694 60.318 1.00 21.03 C +ATOM 501 OE1 GLU A 62 4.980 71.831 59.799 1.00 31.08 O +ATOM 502 OE2 GLU A 62 5.309 73.500 61.178 1.00 26.49 O +ATOM 503 N ILE A 63 9.086 70.332 57.337 1.00 10.12 N +ATOM 504 CA ILE A 63 9.562 70.431 55.971 1.00 11.18 C +ATOM 505 C ILE A 63 10.696 69.407 55.938 1.00 11.64 C +ATOM 506 O ILE A 63 11.590 69.427 56.792 1.00 10.80 O +ATOM 507 CB ILE A 63 9.971 71.905 55.521 1.00 15.57 C +ATOM 508 CG1 ILE A 63 11.312 71.931 54.798 1.00 13.16 C +ATOM 509 CG2 ILE A 63 9.960 72.887 56.655 1.00 23.18 C +ATOM 510 CD1 ILE A 63 11.220 71.371 53.400 1.00 30.69 C +ATOM 511 N LEU A 64 10.591 68.445 55.025 1.00 10.93 N +ATOM 512 CA LEU A 64 11.591 67.392 54.899 1.00 11.25 C +ATOM 513 C LEU A 64 11.845 66.961 53.454 1.00 13.66 C +ATOM 514 O LEU A 64 10.913 66.728 52.686 1.00 13.04 O +ATOM 515 CB LEU A 64 11.147 66.189 55.723 1.00 14.28 C +ATOM 516 CG LEU A 64 11.875 64.846 55.563 1.00 16.48 C +ATOM 517 CD1 LEU A 64 12.635 64.461 56.813 1.00 8.50 C +ATOM 518 CD2 LEU A 64 10.853 63.783 55.258 1.00 12.47 C +ATOM 519 N ILE A 65 13.122 66.888 53.093 1.00 14.55 N +ATOM 520 CA ILE A 65 13.543 66.461 51.759 1.00 14.02 C +ATOM 521 C ILE A 65 14.172 65.083 51.964 1.00 16.96 C +ATOM 522 O ILE A 65 15.145 64.940 52.729 1.00 14.28 O +ATOM 523 CB ILE A 65 14.577 67.417 51.162 1.00 9.77 C +ATOM 524 CG1 ILE A 65 13.959 68.805 51.040 1.00 10.42 C +ATOM 525 CG2 ILE A 65 15.033 66.905 49.804 1.00 8.50 C +ATOM 526 CD1 ILE A 65 14.965 69.904 50.769 1.00 11.93 C +ATOM 527 N PHE A 66 13.654 64.091 51.243 1.00 14.52 N +ATOM 528 CA PHE A 66 14.107 62.723 51.408 1.00 12.99 C +ATOM 529 C PHE A 66 14.205 62.000 50.081 1.00 12.20 C +ATOM 530 O PHE A 66 13.457 62.301 49.153 1.00 10.78 O +ATOM 531 CB PHE A 66 13.046 62.025 52.261 1.00 30.73 C +ATOM 532 CG PHE A 66 13.439 60.668 52.781 1.00 41.10 C +ATOM 533 CD1 PHE A 66 13.157 59.518 52.052 1.00 38.15 C +ATOM 534 CD2 PHE A 66 14.036 60.540 54.031 1.00 39.61 C +ATOM 535 CE1 PHE A 66 13.457 58.273 52.554 1.00 40.32 C +ATOM 536 CE2 PHE A 66 14.338 59.298 54.541 1.00 38.48 C +ATOM 537 CZ PHE A 66 14.048 58.159 53.800 1.00 47.62 C +ATOM 538 N TRP A 67 15.103 61.022 50.001 1.00 12.00 N +ATOM 539 CA TRP A 67 15.231 60.211 48.792 1.00 16.15 C +ATOM 540 C TRP A 67 14.674 58.847 49.133 1.00 19.85 C +ATOM 541 O TRP A 67 15.244 58.157 49.977 1.00 30.28 O +ATOM 542 CB TRP A 67 16.689 60.044 48.378 1.00 8.50 C +ATOM 543 CG TRP A 67 16.875 58.966 47.340 1.00 21.43 C +ATOM 544 CD1 TRP A 67 17.243 57.666 47.562 1.00 27.28 C +ATOM 545 CD2 TRP A 67 16.698 59.090 45.916 1.00 28.64 C +ATOM 546 NE1 TRP A 67 17.307 56.975 46.372 1.00 31.82 N +ATOM 547 CE2 TRP A 67 16.979 57.824 45.347 1.00 30.45 C +ATOM 548 CE3 TRP A 67 16.335 60.146 45.067 1.00 22.47 C +ATOM 549 CZ2 TRP A 67 16.908 57.593 43.980 1.00 25.85 C +ATOM 550 CZ3 TRP A 67 16.270 59.916 43.715 1.00 16.20 C +ATOM 551 CH2 TRP A 67 16.555 58.650 43.182 1.00 29.55 C +ATOM 552 N SER A 68 13.547 58.469 48.535 1.00 21.64 N +ATOM 553 CA SER A 68 12.963 57.155 48.815 1.00 21.40 C +ATOM 554 C SER A 68 13.357 56.183 47.722 1.00 19.86 C +ATOM 555 O SER A 68 13.006 56.360 46.552 1.00 17.12 O +ATOM 556 CB SER A 68 11.433 57.206 49.007 1.00 17.12 C +ATOM 557 OG SER A 68 10.731 57.557 47.834 1.00 9.56 O +ATOM 558 N LYS A 69 14.154 55.198 48.124 1.00 21.82 N +ATOM 559 CA LYS A 69 14.681 54.157 47.255 1.00 23.64 C +ATOM 560 C LYS A 69 13.678 53.715 46.200 1.00 22.15 C +ATOM 561 O LYS A 69 12.506 53.525 46.492 1.00 28.43 O +ATOM 562 CB LYS A 69 15.102 52.966 48.126 1.00 32.00 C +ATOM 563 CG LYS A 69 16.192 52.044 47.565 1.00 42.30 C +ATOM 564 CD LYS A 69 15.681 51.097 46.496 1.00 50.81 C +ATOM 565 CE LYS A 69 16.579 49.871 46.335 1.00 48.28 C +ATOM 566 NZ LYS A 69 16.388 48.914 47.460 1.00 58.85 N +ATOM 567 N ASP A 70 14.142 53.607 44.965 1.00 30.73 N +ATOM 568 CA ASP A 70 13.304 53.169 43.847 1.00 41.66 C +ATOM 569 C ASP A 70 12.164 54.098 43.407 1.00 41.65 C +ATOM 570 O ASP A 70 11.378 53.749 42.516 1.00 47.72 O +ATOM 571 CB ASP A 70 12.720 51.769 44.116 1.00 54.49 C +ATOM 572 CG ASP A 70 13.719 50.638 43.872 1.00 61.42 C +ATOM 573 OD1 ASP A 70 14.794 50.872 43.263 1.00 63.47 O +ATOM 574 OD2 ASP A 70 13.409 49.501 44.295 1.00 65.18 O +ATOM 575 N ILE A 71 12.048 55.264 44.023 1.00 38.02 N +ATOM 576 CA ILE A 71 10.988 56.182 43.634 1.00 31.19 C +ATOM 577 C ILE A 71 11.529 57.523 43.157 1.00 25.63 C +ATOM 578 O ILE A 71 11.369 57.881 41.987 1.00 30.26 O +ATOM 579 CB ILE A 71 9.984 56.400 44.772 1.00 28.49 C +ATOM 580 CG1 ILE A 71 9.305 55.072 45.127 1.00 35.72 C +ATOM 581 CG2 ILE A 71 8.944 57.415 44.353 1.00 24.99 C +ATOM 582 CD1 ILE A 71 8.252 55.186 46.207 1.00 37.45 C +ATOM 583 N GLY A 72 12.176 58.254 44.056 1.00 18.24 N +ATOM 584 CA GLY A 72 12.735 59.547 43.710 1.00 15.07 C +ATOM 585 C GLY A 72 12.777 60.483 44.900 1.00 16.96 C +ATOM 586 O GLY A 72 12.919 60.044 46.040 1.00 22.07 O +ATOM 587 N TYR A 73 12.671 61.779 44.643 1.00 12.30 N +ATOM 588 CA TYR A 73 12.687 62.753 45.710 1.00 8.50 C +ATOM 589 C TYR A 73 11.328 62.853 46.345 1.00 9.24 C +ATOM 590 O TYR A 73 10.300 62.927 45.671 1.00 10.75 O +ATOM 591 CB TYR A 73 13.126 64.098 45.185 1.00 8.50 C +ATOM 592 CG TYR A 73 14.555 64.090 44.749 1.00 8.50 C +ATOM 593 CD1 TYR A 73 15.577 64.103 45.688 1.00 8.50 C +ATOM 594 CD2 TYR A 73 14.889 64.033 43.409 1.00 8.50 C +ATOM 595 CE1 TYR A 73 16.901 64.051 45.301 1.00 8.50 C +ATOM 596 CE2 TYR A 73 16.206 63.979 43.010 1.00 8.50 C +ATOM 597 CZ TYR A 73 17.208 63.987 43.956 1.00 8.86 C +ATOM 598 OH TYR A 73 18.521 63.931 43.544 1.00 23.21 O +ATOM 599 N SER A 74 11.339 62.833 47.663 1.00 11.64 N +ATOM 600 CA SER A 74 10.127 62.919 48.458 1.00 15.46 C +ATOM 601 C SER A 74 10.159 64.243 49.224 1.00 11.85 C +ATOM 602 O SER A 74 10.920 64.417 50.181 1.00 12.01 O +ATOM 603 CB SER A 74 10.069 61.737 49.429 1.00 22.17 C +ATOM 604 OG SER A 74 8.998 61.877 50.352 1.00 30.37 O +ATOM 605 N PHE A 75 9.367 65.194 48.760 1.00 9.68 N +ATOM 606 CA PHE A 75 9.309 66.488 49.401 1.00 10.00 C +ATOM 607 C PHE A 75 8.041 66.553 50.250 1.00 12.60 C +ATOM 608 O PHE A 75 6.927 66.466 49.734 1.00 8.50 O +ATOM 609 CB PHE A 75 9.306 67.602 48.350 1.00 9.31 C +ATOM 610 CG PHE A 75 9.221 68.986 48.926 1.00 8.50 C +ATOM 611 CD1 PHE A 75 10.258 69.495 49.698 1.00 9.77 C +ATOM 612 CD2 PHE A 75 8.086 69.764 48.735 1.00 8.50 C +ATOM 613 CE1 PHE A 75 10.161 70.753 50.275 1.00 8.50 C +ATOM 614 CE2 PHE A 75 7.984 71.025 49.312 1.00 11.52 C +ATOM 615 CZ PHE A 75 9.024 71.518 50.085 1.00 8.50 C +ATOM 616 N THR A 76 8.214 66.726 51.555 1.00 18.00 N +ATOM 617 CA THR A 76 7.079 66.800 52.470 1.00 15.68 C +ATOM 618 C THR A 76 7.100 68.057 53.350 1.00 9.49 C +ATOM 619 O THR A 76 8.118 68.426 53.933 1.00 8.50 O +ATOM 620 CB THR A 76 6.955 65.473 53.318 1.00 20.65 C +ATOM 621 OG1 THR A 76 6.550 65.762 54.663 1.00 19.00 O +ATOM 622 CG2 THR A 76 8.280 64.682 53.325 1.00 17.45 C +ATOM 623 N VAL A 77 5.980 68.753 53.373 1.00 8.50 N +ATOM 624 CA VAL A 77 5.855 69.948 54.185 1.00 18.55 C +ATOM 625 C VAL A 77 4.560 69.850 54.984 1.00 23.39 C +ATOM 626 O VAL A 77 3.494 69.585 54.419 1.00 27.38 O +ATOM 627 CB VAL A 77 5.918 71.281 53.331 1.00 19.12 C +ATOM 628 CG1 VAL A 77 5.293 71.087 51.974 1.00 15.18 C +ATOM 629 CG2 VAL A 77 5.222 72.428 54.062 1.00 13.15 C +ATOM 630 N GLY A 78 4.679 69.973 56.305 1.00 21.02 N +ATOM 631 CA GLY A 78 3.524 69.911 57.174 1.00 17.04 C +ATOM 632 C GLY A 78 2.992 68.502 57.285 1.00 21.86 C +ATOM 633 O GLY A 78 1.779 68.297 57.344 1.00 31.62 O +ATOM 634 N GLY A 79 3.889 67.521 57.299 1.00 19.78 N +ATOM 635 CA GLY A 79 3.457 66.137 57.403 1.00 16.75 C +ATOM 636 C GLY A 79 2.878 65.533 56.131 1.00 18.12 C +ATOM 637 O GLY A 79 2.700 64.322 56.059 1.00 19.56 O +ATOM 638 N SER A 80 2.566 66.360 55.136 1.00 19.92 N +ATOM 639 CA SER A 80 2.023 65.878 53.869 1.00 22.38 C +ATOM 640 C SER A 80 3.136 65.747 52.809 1.00 25.45 C +ATOM 641 O SER A 80 3.889 66.700 52.540 1.00 30.67 O +ATOM 642 CB SER A 80 0.882 66.783 53.386 1.00 24.69 C +ATOM 643 OG SER A 80 -0.252 66.687 54.245 1.00 36.67 O +ATOM 644 N GLU A 81 3.230 64.550 52.228 1.00 20.55 N +ATOM 645 CA GLU A 81 4.241 64.202 51.242 1.00 15.67 C +ATOM 646 C GLU A 81 3.795 64.401 49.791 1.00 17.26 C +ATOM 647 O GLU A 81 2.601 64.451 49.488 1.00 17.96 O +ATOM 648 CB GLU A 81 4.634 62.739 51.472 1.00 16.37 C +ATOM 649 CG GLU A 81 5.693 62.168 50.564 1.00 20.76 C +ATOM 650 CD GLU A 81 5.760 60.667 50.663 1.00 35.53 C +ATOM 651 OE1 GLU A 81 4.731 60.002 50.389 1.00 39.40 O +ATOM 652 OE2 GLU A 81 6.844 60.152 51.016 1.00 47.96 O +ATOM 653 N ILE A 82 4.786 64.516 48.907 1.00 20.25 N +ATOM 654 CA ILE A 82 4.587 64.682 47.471 1.00 12.32 C +ATOM 655 C ILE A 82 5.830 64.065 46.807 1.00 10.55 C +ATOM 656 O ILE A 82 6.937 64.077 47.376 1.00 8.50 O +ATOM 657 CB ILE A 82 4.399 66.179 47.099 1.00 14.68 C +ATOM 658 CG1 ILE A 82 3.567 66.303 45.836 1.00 8.50 C +ATOM 659 CG2 ILE A 82 5.743 66.877 46.905 1.00 14.00 C +ATOM 660 CD1 ILE A 82 3.080 67.681 45.626 1.00 12.20 C +ATOM 661 N LEU A 83 5.659 63.521 45.614 1.00 8.50 N +ATOM 662 CA LEU A 83 6.773 62.859 44.968 1.00 11.43 C +ATOM 663 C LEU A 83 7.255 63.403 43.650 1.00 12.95 C +ATOM 664 O LEU A 83 6.479 63.832 42.809 1.00 14.33 O +ATOM 665 CB LEU A 83 6.454 61.376 44.797 1.00 20.05 C +ATOM 666 CG LEU A 83 6.958 60.369 45.836 1.00 27.17 C +ATOM 667 CD1 LEU A 83 6.730 60.852 47.258 1.00 29.74 C +ATOM 668 CD2 LEU A 83 6.249 59.053 45.610 1.00 30.97 C +ATOM 669 N PHE A 84 8.565 63.332 43.482 1.00 14.00 N +ATOM 670 CA PHE A 84 9.224 63.766 42.280 1.00 15.70 C +ATOM 671 C PHE A 84 10.019 62.564 41.839 1.00 14.05 C +ATOM 672 O PHE A 84 11.125 62.302 42.313 1.00 8.50 O +ATOM 673 CB PHE A 84 10.107 64.992 42.536 1.00 19.66 C +ATOM 674 CG PHE A 84 9.323 66.244 42.738 1.00 14.32 C +ATOM 675 CD1 PHE A 84 8.516 66.728 41.719 1.00 8.50 C +ATOM 676 CD2 PHE A 84 9.318 66.885 43.972 1.00 8.50 C +ATOM 677 CE1 PHE A 84 7.708 67.822 41.924 1.00 9.52 C +ATOM 678 CE2 PHE A 84 8.512 67.982 44.186 1.00 8.50 C +ATOM 679 CZ PHE A 84 7.700 68.457 43.162 1.00 9.18 C +ATOM 680 N GLU A 85 9.381 61.803 40.964 1.00 13.08 N +ATOM 681 CA GLU A 85 9.948 60.591 40.442 1.00 20.35 C +ATOM 682 C GLU A 85 11.230 60.770 39.636 1.00 22.06 C +ATOM 683 O GLU A 85 11.354 61.659 38.802 1.00 27.31 O +ATOM 684 CB GLU A 85 8.886 59.852 39.643 1.00 33.71 C +ATOM 685 CG GLU A 85 7.558 59.750 40.373 1.00 50.20 C +ATOM 686 CD GLU A 85 6.775 58.522 39.976 1.00 67.62 C +ATOM 687 OE1 GLU A 85 6.047 58.587 38.966 1.00 81.82 O +ATOM 688 OE2 GLU A 85 6.893 57.488 40.670 1.00 72.81 O +ATOM 689 N VAL A 86 12.204 59.929 39.942 1.00 29.12 N +ATOM 690 CA VAL A 86 13.499 59.922 39.272 1.00 36.44 C +ATOM 691 C VAL A 86 13.819 58.450 38.983 1.00 48.25 C +ATOM 692 O VAL A 86 14.294 57.722 39.858 1.00 53.66 O +ATOM 693 CB VAL A 86 14.597 60.542 40.157 1.00 20.30 C +ATOM 694 CG1 VAL A 86 15.952 60.353 39.525 1.00 21.32 C +ATOM 695 CG2 VAL A 86 14.316 62.015 40.353 1.00 31.61 C +ATOM 696 N PRO A 87 13.539 57.990 37.744 1.00 56.86 N +ATOM 697 CA PRO A 87 13.767 56.608 37.286 1.00 63.13 C +ATOM 698 C PRO A 87 15.224 56.131 37.257 1.00 70.76 C +ATOM 699 O PRO A 87 15.602 55.189 37.965 1.00 77.27 O +ATOM 700 CB PRO A 87 13.148 56.611 35.887 1.00 55.39 C +ATOM 701 CG PRO A 87 13.391 58.025 35.417 1.00 53.59 C +ATOM 702 CD PRO A 87 13.026 58.829 36.640 1.00 56.67 C +ATOM 703 N GLU A 88 16.023 56.767 36.409 1.00 74.37 N +ATOM 704 CA GLU A 88 17.426 56.426 36.253 1.00 76.82 C +ATOM 705 C GLU A 88 18.239 57.234 37.261 1.00 70.87 C +ATOM 706 O GLU A 88 18.362 58.452 37.133 1.00 68.16 O +ATOM 707 CB GLU A 88 17.877 56.752 34.816 1.00 88.99 C +ATOM 708 CG GLU A 88 19.226 56.142 34.401 1.00104.48 C +ATOM 709 CD GLU A 88 19.744 56.671 33.063 1.00103.93 C +ATOM 710 OE1 GLU A 88 18.933 56.845 32.123 1.00 98.64 O +ATOM 711 OE2 GLU A 88 20.970 56.907 32.958 1.00107.67 O +ATOM 712 N VAL A 89 18.751 56.568 38.287 1.00 67.03 N +ATOM 713 CA VAL A 89 19.548 57.256 39.289 1.00 67.11 C +ATOM 714 C VAL A 89 21.010 57.219 38.890 1.00 62.96 C +ATOM 715 O VAL A 89 21.512 56.192 38.435 1.00 61.90 O +ATOM 716 CB VAL A 89 19.367 56.645 40.701 1.00 74.52 C +ATOM 717 CG1 VAL A 89 19.980 55.235 40.789 1.00 76.36 C +ATOM 718 CG2 VAL A 89 19.965 57.577 41.744 1.00 78.82 C +ATOM 719 N THR A 90 21.679 58.353 39.026 1.00 60.60 N +ATOM 720 CA THR A 90 23.081 58.435 38.673 1.00 61.68 C +ATOM 721 C THR A 90 23.884 58.861 39.888 1.00 55.26 C +ATOM 722 O THR A 90 23.386 59.589 40.758 1.00 57.76 O +ATOM 723 CB THR A 90 23.320 59.434 37.500 1.00 76.48 C +ATOM 724 OG1 THR A 90 24.678 59.326 37.035 1.00 82.63 O +ATOM 725 CG2 THR A 90 23.034 60.888 37.943 1.00 80.63 C +ATOM 726 N VAL A 91 25.128 58.399 39.939 1.00 45.94 N +ATOM 727 CA VAL A 91 26.023 58.720 41.039 1.00 41.45 C +ATOM 728 C VAL A 91 26.955 59.883 40.665 1.00 37.65 C +ATOM 729 O VAL A 91 27.828 59.752 39.795 1.00 40.36 O +ATOM 730 CB VAL A 91 26.824 57.475 41.469 1.00 39.32 C +ATOM 731 CG1 VAL A 91 27.558 56.878 40.287 1.00 44.51 C +ATOM 732 CG2 VAL A 91 27.782 57.823 42.591 1.00 43.27 C +ATOM 733 N ALA A 92 26.706 61.035 41.286 1.00 27.60 N +ATOM 734 CA ALA A 92 27.480 62.253 41.058 1.00 17.16 C +ATOM 735 C ALA A 92 26.938 63.280 42.019 1.00 10.74 C +ATOM 736 O ALA A 92 25.833 63.103 42.537 1.00 15.55 O +ATOM 737 CB ALA A 92 27.287 62.741 39.644 1.00 30.94 C +ATOM 738 N PRO A 93 27.724 64.328 42.331 1.00 8.50 N +ATOM 739 CA PRO A 93 27.146 65.284 43.261 1.00 8.50 C +ATOM 740 C PRO A 93 25.902 65.836 42.596 1.00 11.81 C +ATOM 741 O PRO A 93 25.831 65.905 41.365 1.00 25.19 O +ATOM 742 CB PRO A 93 28.236 66.346 43.373 1.00 8.50 C +ATOM 743 CG PRO A 93 29.470 65.589 43.170 1.00 8.94 C +ATOM 744 CD PRO A 93 29.113 64.698 42.013 1.00 8.50 C +ATOM 745 N VAL A 94 24.906 66.183 43.393 1.00 8.98 N +ATOM 746 CA VAL A 94 23.680 66.727 42.862 1.00 9.00 C +ATOM 747 C VAL A 94 23.307 67.972 43.670 1.00 11.19 C +ATOM 748 O VAL A 94 23.639 68.081 44.854 1.00 8.50 O +ATOM 749 CB VAL A 94 22.575 65.638 42.819 1.00 9.98 C +ATOM 750 CG1 VAL A 94 22.661 64.753 44.022 1.00 24.50 C +ATOM 751 CG2 VAL A 94 21.195 66.251 42.725 1.00 19.30 C +ATOM 752 N HIS A 95 22.735 68.959 42.985 1.00 9.33 N +ATOM 753 CA HIS A 95 22.337 70.212 43.607 1.00 8.50 C +ATOM 754 C HIS A 95 20.832 70.360 43.459 1.00 10.45 C +ATOM 755 O HIS A 95 20.307 70.258 42.353 1.00 15.91 O +ATOM 756 CB HIS A 95 23.064 71.376 42.915 1.00 8.50 C +ATOM 757 CG HIS A 95 22.548 72.725 43.288 1.00 8.50 C +ATOM 758 ND1 HIS A 95 23.056 73.446 44.345 1.00 8.50 N +ATOM 759 CD2 HIS A 95 21.559 73.481 42.755 1.00 10.15 C +ATOM 760 CE1 HIS A 95 22.403 74.589 44.449 1.00 13.41 C +ATOM 761 NE2 HIS A 95 21.488 74.634 43.496 1.00 15.96 N +ATOM 762 N ILE A 96 20.134 70.593 44.560 1.00 8.50 N +ATOM 763 CA ILE A 96 18.695 70.768 44.484 1.00 8.50 C +ATOM 764 C ILE A 96 18.251 72.060 45.166 1.00 8.50 C +ATOM 765 O ILE A 96 18.918 72.554 46.072 1.00 10.54 O +ATOM 766 CB ILE A 96 17.926 69.579 45.131 1.00 13.88 C +ATOM 767 CG1 ILE A 96 18.343 69.403 46.592 1.00 17.60 C +ATOM 768 CG2 ILE A 96 18.191 68.294 44.387 1.00 8.50 C +ATOM 769 CD1 ILE A 96 17.443 68.495 47.346 1.00 16.90 C +ATOM 770 N CYS A 97 17.181 72.648 44.651 1.00 8.50 N +ATOM 771 CA CYS A 97 16.567 73.852 45.212 1.00 8.50 C +ATOM 772 C CYS A 97 15.102 73.497 45.183 1.00 9.12 C +ATOM 773 O CYS A 97 14.598 73.005 44.172 1.00 10.27 O +ATOM 774 CB CYS A 97 16.741 75.104 44.335 1.00 8.50 C +ATOM 775 SG CYS A 97 18.280 76.070 44.466 1.00 8.50 S +ATOM 776 N THR A 98 14.414 73.726 46.284 1.00 9.71 N +ATOM 777 CA THR A 98 13.000 73.424 46.344 1.00 9.74 C +ATOM 778 C THR A 98 12.308 74.596 47.055 1.00 10.50 C +ATOM 779 O THR A 98 12.902 75.235 47.942 1.00 9.64 O +ATOM 780 CB THR A 98 12.769 72.072 47.057 1.00 8.50 C +ATOM 781 OG1 THR A 98 11.378 71.739 47.045 1.00 8.94 O +ATOM 782 CG2 THR A 98 13.297 72.115 48.477 1.00 8.50 C +ATOM 783 N SER A 99 11.090 74.915 46.626 1.00 8.50 N +ATOM 784 CA SER A 99 10.341 76.015 47.210 1.00 11.63 C +ATOM 785 C SER A 99 8.844 75.739 47.364 1.00 13.57 C +ATOM 786 O SER A 99 8.268 74.962 46.608 1.00 19.89 O +ATOM 787 CB SER A 99 10.578 77.308 46.406 1.00 18.93 C +ATOM 788 OG SER A 99 10.319 77.161 45.018 1.00 21.96 O +ATOM 789 N TRP A 100 8.221 76.392 48.340 1.00 14.71 N +ATOM 790 CA TRP A 100 6.793 76.234 48.619 1.00 11.44 C +ATOM 791 C TRP A 100 6.184 77.605 48.954 1.00 14.24 C +ATOM 792 O TRP A 100 6.843 78.467 49.559 1.00 14.48 O +ATOM 793 CB TRP A 100 6.594 75.247 49.777 1.00 9.85 C +ATOM 794 CG TRP A 100 5.219 75.240 50.396 1.00 8.50 C +ATOM 795 CD1 TRP A 100 4.117 74.587 49.940 1.00 8.50 C +ATOM 796 CD2 TRP A 100 4.813 75.922 51.590 1.00 9.42 C +ATOM 797 NE1 TRP A 100 3.049 74.821 50.766 1.00 8.50 N +ATOM 798 CE2 TRP A 100 3.450 75.636 51.789 1.00 8.50 C +ATOM 799 CE3 TRP A 100 5.471 76.759 52.508 1.00 8.80 C +ATOM 800 CZ2 TRP A 100 2.731 76.154 52.866 1.00 11.52 C +ATOM 801 CZ3 TRP A 100 4.755 77.276 53.573 1.00 8.50 C +ATOM 802 CH2 TRP A 100 3.399 76.973 53.744 1.00 9.24 C +ATOM 803 N GLU A 101 4.922 77.796 48.573 1.00 15.44 N +ATOM 804 CA GLU A 101 4.207 79.054 48.798 1.00 15.08 C +ATOM 805 C GLU A 101 2.831 78.755 49.382 1.00 18.48 C +ATOM 806 O GLU A 101 2.009 78.119 48.723 1.00 21.81 O +ATOM 807 CB GLU A 101 4.054 79.785 47.467 1.00 8.83 C +ATOM 808 CG GLU A 101 3.237 81.045 47.527 1.00 24.38 C +ATOM 809 CD GLU A 101 3.045 81.684 46.157 1.00 28.12 C +ATOM 810 OE1 GLU A 101 2.246 81.155 45.362 1.00 17.87 O +ATOM 811 OE2 GLU A 101 3.689 82.724 45.876 1.00 38.22 O +ATOM 812 N SER A 102 2.570 79.232 50.598 1.00 18.02 N +ATOM 813 CA SER A 102 1.288 78.978 51.249 1.00 15.99 C +ATOM 814 C SER A 102 0.126 79.449 50.402 1.00 16.46 C +ATOM 815 O SER A 102 -0.828 78.713 50.174 1.00 22.19 O +ATOM 816 CB SER A 102 1.241 79.637 52.630 1.00 10.48 C +ATOM 817 OG SER A 102 -0.068 79.597 53.162 1.00 8.50 O +ATOM 818 N ALA A 103 0.249 80.656 49.874 1.00 16.33 N +ATOM 819 CA ALA A 103 -0.804 81.267 49.065 1.00 16.28 C +ATOM 820 C ALA A 103 -1.406 80.446 47.921 1.00 16.85 C +ATOM 821 O ALA A 103 -2.574 80.659 47.571 1.00 28.66 O +ATOM 822 CB ALA A 103 -0.345 82.626 48.548 1.00 19.88 C +ATOM 823 N SER A 104 -0.644 79.522 47.340 1.00 8.50 N +ATOM 824 CA SER A 104 -1.165 78.737 46.233 1.00 8.50 C +ATOM 825 C SER A 104 -0.919 77.249 46.373 1.00 10.38 C +ATOM 826 O SER A 104 -1.567 76.427 45.712 1.00 9.45 O +ATOM 827 CB SER A 104 -0.527 79.213 44.956 1.00 8.50 C +ATOM 828 OG SER A 104 0.853 78.927 44.996 1.00 12.26 O +ATOM 829 N GLY A 105 0.047 76.912 47.219 1.00 14.73 N +ATOM 830 CA GLY A 105 0.406 75.526 47.444 1.00 11.91 C +ATOM 831 C GLY A 105 1.380 75.052 46.391 1.00 11.82 C +ATOM 832 O GLY A 105 1.780 73.900 46.381 1.00 20.61 O +ATOM 833 N ILE A 106 1.790 75.941 45.508 1.00 8.50 N +ATOM 834 CA ILE A 106 2.713 75.548 44.471 1.00 10.61 C +ATOM 835 C ILE A 106 4.109 75.289 44.992 1.00 8.97 C +ATOM 836 O ILE A 106 4.734 76.158 45.591 1.00 11.99 O +ATOM 837 CB ILE A 106 2.785 76.582 43.329 1.00 8.50 C +ATOM 838 CG1 ILE A 106 1.453 76.640 42.605 1.00 8.50 C +ATOM 839 CG2 ILE A 106 3.835 76.171 42.325 1.00 12.50 C +ATOM 840 CD1 ILE A 106 1.449 77.590 41.470 1.00 12.96 C +ATOM 841 N VAL A 107 4.593 74.085 44.738 1.00 8.50 N +ATOM 842 CA VAL A 107 5.928 73.700 45.134 1.00 11.82 C +ATOM 843 C VAL A 107 6.728 73.372 43.858 1.00 9.01 C +ATOM 844 O VAL A 107 6.211 72.747 42.943 1.00 9.18 O +ATOM 845 CB VAL A 107 5.898 72.508 46.142 1.00 17.22 C +ATOM 846 CG1 VAL A 107 4.822 71.516 45.761 1.00 18.50 C +ATOM 847 CG2 VAL A 107 7.257 71.820 46.190 1.00 16.35 C +ATOM 848 N GLU A 108 7.940 73.905 43.765 1.00 8.71 N +ATOM 849 CA GLU A 108 8.819 73.683 42.629 1.00 8.50 C +ATOM 850 C GLU A 108 9.979 72.844 43.144 1.00 10.91 C +ATOM 851 O GLU A 108 10.364 72.959 44.308 1.00 12.16 O +ATOM 852 CB GLU A 108 9.429 75.010 42.133 1.00 15.92 C +ATOM 853 CG GLU A 108 8.486 76.093 41.588 1.00 13.47 C +ATOM 854 CD GLU A 108 9.196 77.442 41.346 1.00 17.39 C +ATOM 855 OE1 GLU A 108 10.390 77.607 41.688 1.00 16.07 O +ATOM 856 OE2 GLU A 108 8.548 78.370 40.828 1.00 29.76 O +ATOM 857 N PHE A 109 10.557 72.019 42.281 1.00 12.51 N +ATOM 858 CA PHE A 109 11.707 71.209 42.669 1.00 9.10 C +ATOM 859 C PHE A 109 12.667 71.341 41.496 1.00 8.50 C +ATOM 860 O PHE A 109 12.291 71.057 40.364 1.00 12.08 O +ATOM 861 CB PHE A 109 11.283 69.752 42.876 1.00 10.46 C +ATOM 862 CG PHE A 109 12.182 68.970 43.805 1.00 16.72 C +ATOM 863 CD1 PHE A 109 11.975 68.997 45.176 1.00 11.92 C +ATOM 864 CD2 PHE A 109 13.252 68.231 43.312 1.00 17.18 C +ATOM 865 CE1 PHE A 109 12.819 68.313 46.040 1.00 8.50 C +ATOM 866 CE2 PHE A 109 14.091 67.550 44.175 1.00 11.23 C +ATOM 867 CZ PHE A 109 13.868 67.599 45.543 1.00 8.50 C +ATOM 868 N TRP A 110 13.848 71.888 41.745 1.00 8.50 N +ATOM 869 CA TRP A 110 14.842 72.074 40.704 1.00 8.50 C +ATOM 870 C TRP A 110 16.007 71.155 40.978 1.00 9.46 C +ATOM 871 O TRP A 110 16.625 71.246 42.034 1.00 13.43 O +ATOM 872 CB TRP A 110 15.384 73.503 40.715 1.00 8.50 C +ATOM 873 CG TRP A 110 14.384 74.565 40.427 1.00 17.34 C +ATOM 874 CD1 TRP A 110 13.336 74.934 41.216 1.00 13.93 C +ATOM 875 CD2 TRP A 110 14.304 75.375 39.243 1.00 11.52 C +ATOM 876 NE1 TRP A 110 12.602 75.911 40.596 1.00 12.03 N +ATOM 877 CE2 TRP A 110 13.170 76.197 39.381 1.00 11.04 C +ATOM 878 CE3 TRP A 110 15.071 75.470 38.079 1.00 8.50 C +ATOM 879 CZ2 TRP A 110 12.778 77.100 38.396 1.00 8.50 C +ATOM 880 CZ3 TRP A 110 14.686 76.363 37.102 1.00 11.82 C +ATOM 881 CH2 TRP A 110 13.545 77.168 37.266 1.00 11.82 C +ATOM 882 N VAL A 111 16.333 70.289 40.028 1.00 8.50 N +ATOM 883 CA VAL A 111 17.451 69.388 40.200 1.00 8.50 C +ATOM 884 C VAL A 111 18.498 69.775 39.189 1.00 8.50 C +ATOM 885 O VAL A 111 18.232 69.799 37.997 1.00 12.84 O +ATOM 886 CB VAL A 111 17.038 67.922 39.990 1.00 8.76 C +ATOM 887 CG1 VAL A 111 18.227 67.001 40.211 1.00 13.73 C +ATOM 888 CG2 VAL A 111 15.915 67.543 40.936 1.00 12.40 C +ATOM 889 N ASP A 112 19.679 70.117 39.681 1.00 9.43 N +ATOM 890 CA ASP A 112 20.808 70.529 38.847 1.00 10.54 C +ATOM 891 C ASP A 112 20.507 71.689 37.897 1.00 9.71 C +ATOM 892 O ASP A 112 20.925 71.688 36.740 1.00 9.59 O +ATOM 893 CB ASP A 112 21.400 69.347 38.070 1.00 11.16 C +ATOM 894 CG ASP A 112 22.351 68.521 38.884 1.00 8.50 C +ATOM 895 OD1 ASP A 112 23.040 69.076 39.748 1.00 8.92 O +ATOM 896 OD2 ASP A 112 22.434 67.307 38.636 1.00 16.13 O +ATOM 897 N GLY A 113 19.784 72.680 38.401 1.00 11.67 N +ATOM 898 CA GLY A 113 19.465 73.844 37.595 1.00 11.87 C +ATOM 899 C GLY A 113 18.283 73.719 36.656 1.00 12.91 C +ATOM 900 O GLY A 113 17.870 74.718 36.054 1.00 18.87 O +ATOM 901 N LYS A 114 17.763 72.503 36.493 1.00 11.17 N +ATOM 902 CA LYS A 114 16.605 72.285 35.628 1.00 8.50 C +ATOM 903 C LYS A 114 15.375 71.938 36.456 1.00 8.50 C +ATOM 904 O LYS A 114 15.406 71.094 37.360 1.00 11.86 O +ATOM 905 CB LYS A 114 16.894 71.320 34.480 1.00 18.01 C +ATOM 906 CG LYS A 114 17.865 71.914 33.417 1.00 34.50 C +ATOM 907 CD LYS A 114 17.310 73.219 32.791 1.00 45.97 C +ATOM 908 CE LYS A 114 18.283 74.425 32.890 1.00 46.76 C +ATOM 909 NZ LYS A 114 17.550 75.759 33.002 1.00 39.43 N +ATOM 910 N PRO A 115 14.283 72.650 36.200 1.00 8.50 N +ATOM 911 CA PRO A 115 13.016 72.501 36.892 1.00 8.65 C +ATOM 912 C PRO A 115 12.161 71.301 36.563 1.00 11.31 C +ATOM 913 O PRO A 115 12.071 70.901 35.405 1.00 13.76 O +ATOM 914 CB PRO A 115 12.295 73.770 36.485 1.00 8.50 C +ATOM 915 CG PRO A 115 12.653 73.867 35.070 1.00 8.50 C +ATOM 916 CD PRO A 115 14.138 73.603 35.087 1.00 8.50 C +ATOM 917 N ARG A 116 11.531 70.754 37.599 1.00 8.98 N +ATOM 918 CA ARG A 116 10.594 69.654 37.470 1.00 11.77 C +ATOM 919 C ARG A 116 9.270 70.416 37.400 1.00 12.62 C +ATOM 920 O ARG A 116 9.234 71.607 37.718 1.00 13.04 O +ATOM 921 CB ARG A 116 10.623 68.770 38.721 1.00 12.77 C +ATOM 922 CG ARG A 116 11.988 68.209 39.059 1.00 15.14 C +ATOM 923 CD ARG A 116 12.400 67.082 38.128 1.00 38.65 C +ATOM 924 NE ARG A 116 11.703 65.834 38.445 1.00 39.64 N +ATOM 925 CZ ARG A 116 10.632 65.387 37.797 1.00 38.85 C +ATOM 926 NH1 ARG A 116 10.120 66.077 36.781 1.00 41.48 N +ATOM 927 NH2 ARG A 116 10.070 64.253 38.168 1.00 34.00 N +ATOM 928 N VAL A 117 8.186 69.749 37.025 1.00 12.45 N +ATOM 929 CA VAL A 117 6.904 70.432 36.929 1.00 10.41 C +ATOM 930 C VAL A 117 6.455 70.959 38.283 1.00 15.80 C +ATOM 931 O VAL A 117 6.972 70.536 39.316 1.00 16.50 O +ATOM 932 CB VAL A 117 5.799 69.543 36.368 1.00 8.50 C +ATOM 933 CG1 VAL A 117 4.726 70.406 35.742 1.00 9.45 C +ATOM 934 CG2 VAL A 117 6.358 68.578 35.339 1.00 24.76 C +ATOM 935 N ARG A 118 5.527 71.920 38.265 1.00 18.72 N +ATOM 936 CA ARG A 118 5.005 72.516 39.492 1.00 13.18 C +ATOM 937 C ARG A 118 3.862 71.683 40.028 1.00 9.51 C +ATOM 938 O ARG A 118 2.996 71.268 39.276 1.00 11.71 O +ATOM 939 CB ARG A 118 4.507 73.929 39.244 1.00 10.05 C +ATOM 940 CG ARG A 118 5.546 74.885 38.709 1.00 9.02 C +ATOM 941 CD ARG A 118 5.026 76.303 38.831 1.00 12.76 C +ATOM 942 NE ARG A 118 5.425 77.144 37.718 1.00 8.50 N +ATOM 943 CZ ARG A 118 6.325 78.110 37.804 1.00 8.50 C +ATOM 944 NH1 ARG A 118 6.926 78.366 38.945 1.00 8.50 N +ATOM 945 NH2 ARG A 118 6.614 78.831 36.748 1.00 11.62 N +ATOM 946 N LYS A 119 3.860 71.468 41.339 1.00 13.13 N +ATOM 947 CA LYS A 119 2.836 70.670 41.987 1.00 11.36 C +ATOM 948 C LYS A 119 2.199 71.453 43.120 1.00 12.02 C +ATOM 949 O LYS A 119 2.724 72.489 43.519 1.00 12.99 O +ATOM 950 CB LYS A 119 3.442 69.362 42.475 1.00 8.50 C +ATOM 951 CG LYS A 119 3.908 68.482 41.322 1.00 8.50 C +ATOM 952 CD LYS A 119 4.366 67.106 41.762 1.00 8.50 C +ATOM 953 CE LYS A 119 4.570 66.204 40.575 1.00 13.28 C +ATOM 954 NZ LYS A 119 5.042 64.850 40.936 1.00 29.62 N +ATOM 955 N SER A 120 1.037 70.997 43.588 1.00 15.40 N +ATOM 956 CA SER A 120 0.318 71.676 44.669 1.00 12.41 C +ATOM 957 C SER A 120 0.478 70.878 45.959 1.00 9.74 C +ATOM 958 O SER A 120 0.416 69.653 45.940 1.00 14.88 O +ATOM 959 CB SER A 120 -1.165 71.818 44.304 1.00 8.99 C +ATOM 960 OG SER A 120 -1.794 72.827 45.065 1.00 13.32 O +ATOM 961 N LEU A 121 0.678 71.568 47.074 1.00 8.67 N +ATOM 962 CA LEU A 121 0.857 70.917 48.356 1.00 10.14 C +ATOM 963 C LEU A 121 0.709 71.876 49.527 1.00 16.99 C +ATOM 964 O LEU A 121 1.343 72.935 49.565 1.00 18.07 O +ATOM 965 CB LEU A 121 2.231 70.245 48.405 1.00 14.09 C +ATOM 966 CG LEU A 121 2.755 69.728 49.751 1.00 14.16 C +ATOM 967 CD1 LEU A 121 1.780 68.744 50.356 1.00 21.60 C +ATOM 968 CD2 LEU A 121 4.096 69.064 49.542 1.00 14.74 C +ATOM 969 N LYS A 122 -0.154 71.497 50.472 1.00 22.04 N +ATOM 970 CA LYS A 122 -0.417 72.268 51.696 1.00 17.51 C +ATOM 971 C LYS A 122 -0.757 73.752 51.526 1.00 20.14 C +ATOM 972 O LYS A 122 -0.181 74.609 52.219 1.00 13.70 O +ATOM 973 CB LYS A 122 0.750 72.127 52.685 1.00 15.91 C +ATOM 974 CG LYS A 122 0.710 70.860 53.501 1.00 21.12 C +ATOM 975 CD LYS A 122 -0.440 70.899 54.492 1.00 33.55 C +ATOM 976 CE LYS A 122 -0.485 69.640 55.353 1.00 38.04 C +ATOM 977 NZ LYS A 122 -1.549 69.686 56.396 1.00 46.78 N +ATOM 978 N LYS A 123 -1.712 74.050 50.637 1.00 20.16 N +ATOM 979 CA LYS A 123 -2.121 75.435 50.423 1.00 16.65 C +ATOM 980 C LYS A 123 -2.726 75.988 51.706 1.00 19.02 C +ATOM 981 O LYS A 123 -3.413 75.276 52.436 1.00 24.08 O +ATOM 982 CB LYS A 123 -3.150 75.547 49.302 1.00 9.08 C +ATOM 983 CG LYS A 123 -3.573 76.980 49.076 1.00 11.91 C +ATOM 984 CD LYS A 123 -4.958 77.100 48.483 1.00 21.28 C +ATOM 985 CE LYS A 123 -4.966 76.885 46.995 1.00 9.93 C +ATOM 986 NZ LYS A 123 -6.270 77.351 46.439 1.00 17.28 N +ATOM 987 N GLY A 124 -2.454 77.255 51.990 1.00 22.27 N +ATOM 988 CA GLY A 124 -2.991 77.873 53.187 1.00 21.97 C +ATOM 989 C GLY A 124 -2.273 77.516 54.480 1.00 22.52 C +ATOM 990 O GLY A 124 -2.473 78.190 55.503 1.00 27.37 O +ATOM 991 N TYR A 125 -1.452 76.464 54.456 1.00 18.10 N +ATOM 992 CA TYR A 125 -0.713 76.053 55.647 1.00 19.19 C +ATOM 993 C TYR A 125 0.285 77.148 56.027 1.00 21.20 C +ATOM 994 O TYR A 125 0.469 78.118 55.290 1.00 25.72 O +ATOM 995 CB TYR A 125 0.024 74.743 55.385 1.00 16.65 C +ATOM 996 CG TYR A 125 0.676 74.127 56.613 1.00 26.02 C +ATOM 997 CD1 TYR A 125 -0.064 73.365 57.514 1.00 32.98 C +ATOM 998 CD2 TYR A 125 2.042 74.282 56.862 1.00 33.96 C +ATOM 999 CE1 TYR A 125 0.541 72.772 58.632 1.00 33.06 C +ATOM 1000 CE2 TYR A 125 2.657 73.689 57.983 1.00 28.34 C +ATOM 1001 CZ TYR A 125 1.900 72.943 58.857 1.00 26.76 C +ATOM 1002 OH TYR A 125 2.481 72.379 59.968 1.00 23.59 O +ATOM 1003 N THR A 126 0.906 77.008 57.188 1.00 21.47 N +ATOM 1004 CA THR A 126 1.896 77.973 57.657 1.00 23.18 C +ATOM 1005 C THR A 126 2.929 77.236 58.515 1.00 22.73 C +ATOM 1006 O THR A 126 2.591 76.566 59.488 1.00 24.17 O +ATOM 1007 CB THR A 126 1.228 79.168 58.389 1.00 16.46 C +ATOM 1008 OG1 THR A 126 2.183 79.806 59.237 1.00 17.61 O +ATOM 1009 CG2 THR A 126 0.003 78.737 59.186 1.00 26.01 C +ATOM 1010 N VAL A 127 4.178 77.273 58.067 1.00 21.42 N +ATOM 1011 CA VAL A 127 5.272 76.571 58.731 1.00 17.88 C +ATOM 1012 C VAL A 127 5.686 77.208 60.048 1.00 17.11 C +ATOM 1013 O VAL A 127 5.778 78.425 60.150 1.00 16.91 O +ATOM 1014 CB VAL A 127 6.490 76.431 57.770 1.00 9.23 C +ATOM 1015 CG1 VAL A 127 7.685 75.809 58.473 1.00 15.02 C +ATOM 1016 CG2 VAL A 127 6.100 75.593 56.588 1.00 8.50 C +ATOM 1017 N GLY A 128 5.934 76.369 61.047 1.00 20.09 N +ATOM 1018 CA GLY A 128 6.329 76.843 62.368 1.00 30.02 C +ATOM 1019 C GLY A 128 7.669 77.566 62.397 1.00 31.25 C +ATOM 1020 O GLY A 128 8.605 77.160 61.705 1.00 30.60 O +ATOM 1021 N ALA A 129 7.760 78.596 63.243 1.00 33.30 N +ATOM 1022 CA ALA A 129 8.961 79.418 63.365 1.00 33.31 C +ATOM 1023 C ALA A 129 10.088 78.870 64.233 1.00 40.05 C +ATOM 1024 O ALA A 129 11.262 79.092 63.940 1.00 42.12 O +ATOM 1025 CB ALA A 129 8.573 80.797 63.831 1.00 35.49 C +ATOM 1026 N GLU A 130 9.743 78.227 65.344 1.00 46.01 N +ATOM 1027 CA GLU A 130 10.776 77.663 66.216 1.00 51.10 C +ATOM 1028 C GLU A 130 10.970 76.211 65.815 1.00 45.84 C +ATOM 1029 O GLU A 130 10.082 75.373 66.020 1.00 46.14 O +ATOM 1030 CB GLU A 130 10.393 77.782 67.694 1.00 67.91 C +ATOM 1031 CG GLU A 130 9.032 77.212 68.066 1.00 90.19 C +ATOM 1032 CD GLU A 130 8.737 77.373 69.543 1.00100.55 C +ATOM 1033 OE1 GLU A 130 8.179 78.429 69.921 1.00106.23 O +ATOM 1034 OE2 GLU A 130 9.077 76.453 70.323 1.00105.71 O +ATOM 1035 N ALA A 131 12.129 75.916 65.239 1.00 39.78 N +ATOM 1036 CA ALA A 131 12.382 74.575 64.766 1.00 30.53 C +ATOM 1037 C ALA A 131 13.790 74.062 64.939 1.00 21.74 C +ATOM 1038 O ALA A 131 14.738 74.825 65.112 1.00 24.41 O +ATOM 1039 CB ALA A 131 11.989 74.480 63.305 1.00 33.84 C +ATOM 1040 N SER A 132 13.894 72.738 64.892 1.00 17.46 N +ATOM 1041 CA SER A 132 15.158 72.025 64.986 1.00 22.63 C +ATOM 1042 C SER A 132 15.452 71.579 63.550 1.00 24.14 C +ATOM 1043 O SER A 132 14.679 70.814 62.957 1.00 21.61 O +ATOM 1044 CB SER A 132 15.022 70.794 65.889 1.00 17.27 C +ATOM 1045 OG SER A 132 16.247 70.066 65.965 1.00 21.51 O +ATOM 1046 N ILE A 133 16.520 72.127 62.982 1.00 20.64 N +ATOM 1047 CA ILE A 133 16.933 71.827 61.625 1.00 15.45 C +ATOM 1048 C ILE A 133 18.166 70.923 61.680 1.00 14.42 C +ATOM 1049 O ILE A 133 19.230 71.332 62.146 1.00 16.20 O +ATOM 1050 CB ILE A 133 17.271 73.125 60.872 1.00 16.38 C +ATOM 1051 CG1 ILE A 133 16.088 74.095 60.946 1.00 11.14 C +ATOM 1052 CG2 ILE A 133 17.611 72.807 59.423 1.00 22.24 C +ATOM 1053 CD1 ILE A 133 16.351 75.446 60.324 1.00 9.87 C +ATOM 1054 N ILE A 134 18.032 69.698 61.192 1.00 10.60 N +ATOM 1055 CA ILE A 134 19.142 68.763 61.237 1.00 10.13 C +ATOM 1056 C ILE A 134 19.570 68.198 59.901 1.00 10.14 C +ATOM 1057 O ILE A 134 18.756 67.904 59.020 1.00 11.48 O +ATOM 1058 CB ILE A 134 18.861 67.628 62.251 1.00 22.35 C +ATOM 1059 CG1 ILE A 134 19.024 68.176 63.677 1.00 27.63 C +ATOM 1060 CG2 ILE A 134 19.762 66.407 62.000 1.00 17.40 C +ATOM 1061 CD1 ILE A 134 18.751 67.181 64.764 1.00 30.51 C +ATOM 1062 N LEU A 135 20.878 68.054 59.768 1.00 8.50 N +ATOM 1063 CA LEU A 135 21.491 67.554 58.555 1.00 9.80 C +ATOM 1064 C LEU A 135 22.043 66.176 58.820 1.00 17.07 C +ATOM 1065 O LEU A 135 22.687 65.960 59.857 1.00 18.72 O +ATOM 1066 CB LEU A 135 22.649 68.473 58.142 1.00 8.50 C +ATOM 1067 CG LEU A 135 22.450 69.530 57.045 1.00 14.05 C +ATOM 1068 CD1 LEU A 135 21.054 70.143 57.097 1.00 20.98 C +ATOM 1069 CD2 LEU A 135 23.536 70.600 57.168 1.00 8.68 C +ATOM 1070 N GLY A 136 21.766 65.237 57.915 1.00 19.85 N +ATOM 1071 CA GLY A 136 22.292 63.888 58.070 1.00 24.79 C +ATOM 1072 C GLY A 136 21.486 62.846 58.825 1.00 24.56 C +ATOM 1073 O GLY A 136 21.814 61.670 58.757 1.00 24.12 O +ATOM 1074 N GLN A 137 20.479 63.267 59.582 1.00 21.83 N +ATOM 1075 CA GLN A 137 19.646 62.337 60.338 1.00 17.98 C +ATOM 1076 C GLN A 137 18.180 62.627 60.120 1.00 20.10 C +ATOM 1077 O GLN A 137 17.828 63.754 59.752 1.00 21.24 O +ATOM 1078 CB GLN A 137 19.954 62.416 61.827 1.00 20.04 C +ATOM 1079 CG GLN A 137 21.168 61.618 62.268 1.00 8.50 C +ATOM 1080 CD GLN A 137 21.123 60.169 61.816 1.00 23.32 C +ATOM 1081 OE1 GLN A 137 22.160 59.530 61.743 1.00 23.36 O +ATOM 1082 NE2 GLN A 137 19.918 59.637 61.513 1.00 22.37 N +ATOM 1083 N GLU A 138 17.328 61.622 60.348 1.00 17.67 N +ATOM 1084 CA GLU A 138 15.898 61.805 60.150 1.00 18.12 C +ATOM 1085 C GLU A 138 15.190 62.037 61.461 1.00 19.30 C +ATOM 1086 O GLU A 138 15.080 61.132 62.264 1.00 23.24 O +ATOM 1087 CB GLU A 138 15.292 60.602 59.439 1.00 8.50 C +ATOM 1088 CG GLU A 138 14.051 60.925 58.625 1.00 21.18 C +ATOM 1089 CD GLU A 138 12.811 61.251 59.462 1.00 30.97 C +ATOM 1090 OE1 GLU A 138 12.078 60.321 59.861 1.00 28.61 O +ATOM 1091 OE2 GLU A 138 12.541 62.445 59.681 1.00 37.01 O +ATOM 1092 N GLN A 139 14.705 63.256 61.670 1.00 22.75 N +ATOM 1093 CA GLN A 139 13.990 63.604 62.894 1.00 25.29 C +ATOM 1094 C GLN A 139 12.582 63.027 62.990 1.00 33.48 C +ATOM 1095 O GLN A 139 11.778 63.096 62.052 1.00 34.88 O +ATOM 1096 CB GLN A 139 13.917 65.119 63.064 1.00 22.98 C +ATOM 1097 CG GLN A 139 15.025 65.706 63.923 1.00 20.15 C +ATOM 1098 CD GLN A 139 15.184 67.188 63.712 1.00 15.96 C +ATOM 1099 OE1 GLN A 139 15.962 67.606 62.880 1.00 18.88 O +ATOM 1100 NE2 GLN A 139 14.417 67.988 64.435 1.00 19.58 N +ATOM 1101 N ASP A 140 12.293 62.461 64.148 1.00 39.51 N +ATOM 1102 CA ASP A 140 10.990 61.888 64.421 1.00 45.13 C +ATOM 1103 C ASP A 140 10.477 62.443 65.745 1.00 48.60 C +ATOM 1104 O ASP A 140 9.455 61.995 66.275 1.00 58.52 O +ATOM 1105 CB ASP A 140 11.051 60.361 64.404 1.00 42.79 C +ATOM 1106 CG ASP A 140 11.191 59.812 62.994 1.00 55.67 C +ATOM 1107 OD1 ASP A 140 10.537 60.365 62.075 1.00 57.37 O +ATOM 1108 OD2 ASP A 140 11.960 58.844 62.795 1.00 54.96 O +ATOM 1109 N SER A 141 11.194 63.441 66.255 1.00 42.97 N +ATOM 1110 CA SER A 141 10.842 64.143 67.479 1.00 40.41 C +ATOM 1111 C SER A 141 11.738 65.367 67.457 1.00 36.99 C +ATOM 1112 O SER A 141 12.813 65.344 66.858 1.00 37.65 O +ATOM 1113 CB SER A 141 11.117 63.292 68.724 1.00 36.11 C +ATOM 1114 OG SER A 141 12.488 63.289 69.065 1.00 39.90 O +ATOM 1115 N PHE A 142 11.287 66.443 68.075 1.00 30.74 N +ATOM 1116 CA PHE A 142 12.066 67.663 68.101 1.00 31.17 C +ATOM 1117 C PHE A 142 13.510 67.426 68.539 1.00 34.62 C +ATOM 1118 O PHE A 142 13.798 67.239 69.717 1.00 38.62 O +ATOM 1119 CB PHE A 142 11.400 68.674 69.018 1.00 35.38 C +ATOM 1120 CG PHE A 142 11.928 70.069 68.880 1.00 35.26 C +ATOM 1121 CD1 PHE A 142 11.355 70.944 67.958 1.00 37.48 C +ATOM 1122 CD2 PHE A 142 12.940 70.534 69.722 1.00 35.07 C +ATOM 1123 CE1 PHE A 142 11.766 72.261 67.877 1.00 46.36 C +ATOM 1124 CE2 PHE A 142 13.365 71.851 69.655 1.00 45.55 C +ATOM 1125 CZ PHE A 142 12.776 72.723 68.730 1.00 54.01 C +ATOM 1126 N GLY A 143 14.408 67.399 67.562 1.00 39.03 N +ATOM 1127 CA GLY A 143 15.825 67.219 67.838 1.00 37.92 C +ATOM 1128 C GLY A 143 16.297 65.814 68.159 1.00 37.85 C +ATOM 1129 O GLY A 143 17.437 65.645 68.614 1.00 33.96 O +ATOM 1130 N GLY A 144 15.465 64.812 67.883 1.00 33.60 N +ATOM 1131 CA GLY A 144 15.865 63.453 68.173 1.00 37.00 C +ATOM 1132 C GLY A 144 15.059 62.368 67.497 1.00 42.51 C +ATOM 1133 O GLY A 144 14.323 62.623 66.542 1.00 44.40 O +ATOM 1134 N ASN A 145 15.200 61.150 68.023 1.00 47.07 N +ATOM 1135 CA ASN A 145 14.525 59.958 67.515 1.00 46.54 C +ATOM 1136 C ASN A 145 15.025 59.639 66.119 1.00 41.08 C +ATOM 1137 O ASN A 145 14.262 59.553 65.163 1.00 42.16 O +ATOM 1138 CB ASN A 145 13.000 60.120 67.542 1.00 51.08 C +ATOM 1139 CG ASN A 145 12.411 59.854 68.918 1.00 65.65 C +ATOM 1140 OD1 ASN A 145 12.729 60.546 69.888 1.00 76.40 O +ATOM 1141 ND2 ASN A 145 11.547 58.850 69.012 1.00 71.55 N +ATOM 1142 N PHE A 146 16.325 59.422 66.029 1.00 33.84 N +ATOM 1143 CA PHE A 146 16.965 59.134 64.768 1.00 37.40 C +ATOM 1144 C PHE A 146 16.964 57.661 64.364 1.00 42.28 C +ATOM 1145 O PHE A 146 17.417 56.801 65.113 1.00 47.75 O +ATOM 1146 CB PHE A 146 18.415 59.625 64.813 1.00 31.95 C +ATOM 1147 CG PHE A 146 18.561 61.072 65.169 1.00 22.14 C +ATOM 1148 CD1 PHE A 146 17.627 62.009 64.742 1.00 24.42 C +ATOM 1149 CD2 PHE A 146 19.633 61.499 65.938 1.00 15.56 C +ATOM 1150 CE1 PHE A 146 17.759 63.357 65.079 1.00 22.52 C +ATOM 1151 CE2 PHE A 146 19.772 62.841 66.279 1.00 16.82 C +ATOM 1152 CZ PHE A 146 18.838 63.772 65.852 1.00 17.69 C +ATOM 1153 N GLU A 147 16.460 57.370 63.174 1.00 44.81 N +ATOM 1154 CA GLU A 147 16.476 56.009 62.657 1.00 45.05 C +ATOM 1155 C GLU A 147 17.695 55.909 61.736 1.00 45.38 C +ATOM 1156 O GLU A 147 17.818 56.644 60.760 1.00 47.31 O +ATOM 1157 CB GLU A 147 15.193 55.706 61.900 1.00 40.77 C +ATOM 1158 CG GLU A 147 15.323 54.640 60.826 1.00 50.39 C +ATOM 1159 CD GLU A 147 15.252 53.224 61.352 1.00 56.55 C +ATOM 1160 OE1 GLU A 147 16.221 52.778 62.004 1.00 48.51 O +ATOM 1161 OE2 GLU A 147 14.228 52.547 61.084 1.00 60.47 O +ATOM 1162 N GLY A 148 18.614 55.018 62.084 1.00 48.94 N +ATOM 1163 CA GLY A 148 19.835 54.830 61.317 1.00 43.94 C +ATOM 1164 C GLY A 148 19.648 54.355 59.892 1.00 42.08 C +ATOM 1165 O GLY A 148 20.564 54.454 59.082 1.00 43.58 O +ATOM 1166 N SER A 149 18.462 53.836 59.594 1.00 42.26 N +ATOM 1167 CA SER A 149 18.111 53.347 58.261 1.00 41.35 C +ATOM 1168 C SER A 149 17.782 54.532 57.344 1.00 37.16 C +ATOM 1169 O SER A 149 17.487 54.356 56.165 1.00 41.33 O +ATOM 1170 CB SER A 149 16.900 52.409 58.368 1.00 47.97 C +ATOM 1171 OG SER A 149 16.554 51.806 57.134 1.00 63.62 O +ATOM 1172 N GLN A 150 17.833 55.738 57.900 1.00 28.82 N +ATOM 1173 CA GLN A 150 17.532 56.953 57.157 1.00 23.67 C +ATOM 1174 C GLN A 150 18.639 58.004 57.351 1.00 28.99 C +ATOM 1175 O GLN A 150 18.438 59.207 57.134 1.00 34.55 O +ATOM 1176 CB GLN A 150 16.169 57.507 57.598 1.00 16.15 C +ATOM 1177 CG GLN A 150 15.074 56.458 57.639 1.00 9.21 C +ATOM 1178 CD GLN A 150 13.707 57.037 57.882 1.00 21.75 C +ATOM 1179 OE1 GLN A 150 13.486 57.797 58.829 1.00 27.12 O +ATOM 1180 NE2 GLN A 150 12.770 56.680 57.022 1.00 29.51 N +ATOM 1181 N SER A 151 19.812 57.542 57.767 1.00 30.39 N +ATOM 1182 CA SER A 151 20.946 58.432 57.979 1.00 28.26 C +ATOM 1183 C SER A 151 21.597 58.715 56.640 1.00 24.24 C +ATOM 1184 O SER A 151 21.406 57.969 55.688 1.00 33.49 O +ATOM 1185 CB SER A 151 21.978 57.772 58.902 1.00 40.09 C +ATOM 1186 OG SER A 151 23.053 58.661 59.176 1.00 56.04 O +ATOM 1187 N LEU A 152 22.345 59.798 56.541 1.00 20.52 N +ATOM 1188 CA LEU A 152 23.015 60.086 55.284 1.00 11.67 C +ATOM 1189 C LEU A 152 24.486 59.729 55.384 1.00 12.76 C +ATOM 1190 O LEU A 152 25.162 60.054 56.371 1.00 14.68 O +ATOM 1191 CB LEU A 152 22.890 61.560 54.915 1.00 16.45 C +ATOM 1192 CG LEU A 152 23.751 62.042 53.739 1.00 12.63 C +ATOM 1193 CD1 LEU A 152 23.079 61.697 52.430 1.00 10.36 C +ATOM 1194 CD2 LEU A 152 23.946 63.521 53.817 1.00 12.99 C +ATOM 1195 N VAL A 153 24.984 59.051 54.361 1.00 11.99 N +ATOM 1196 CA VAL A 153 26.387 58.675 54.328 1.00 12.05 C +ATOM 1197 C VAL A 153 26.956 59.290 53.056 1.00 14.50 C +ATOM 1198 O VAL A 153 26.605 58.878 51.941 1.00 13.76 O +ATOM 1199 CB VAL A 153 26.573 57.147 54.289 1.00 10.28 C +ATOM 1200 CG1 VAL A 153 28.034 56.807 54.530 1.00 15.44 C +ATOM 1201 CG2 VAL A 153 25.678 56.474 55.304 1.00 8.50 C +ATOM 1202 N GLY A 154 27.782 60.311 53.235 1.00 11.68 N +ATOM 1203 CA GLY A 154 28.389 61.009 52.117 1.00 9.20 C +ATOM 1204 C GLY A 154 28.644 62.453 52.500 1.00 13.76 C +ATOM 1205 O GLY A 154 28.801 62.756 53.681 1.00 19.62 O +ATOM 1206 N ASP A 155 28.660 63.357 51.529 1.00 10.77 N +ATOM 1207 CA ASP A 155 28.910 64.769 51.798 1.00 8.50 C +ATOM 1208 C ASP A 155 27.667 65.585 51.561 1.00 8.74 C +ATOM 1209 O ASP A 155 26.837 65.247 50.710 1.00 11.49 O +ATOM 1210 CB ASP A 155 29.971 65.321 50.862 1.00 8.50 C +ATOM 1211 CG ASP A 155 31.338 64.764 51.120 1.00 9.13 C +ATOM 1212 OD1 ASP A 155 31.498 63.521 51.100 1.00 17.79 O +ATOM 1213 OD2 ASP A 155 32.270 65.583 51.298 1.00 8.55 O +ATOM 1214 N ILE A 156 27.550 66.683 52.294 1.00 8.72 N +ATOM 1215 CA ILE A 156 26.423 67.594 52.130 1.00 8.50 C +ATOM 1216 C ILE A 156 26.988 68.968 52.428 1.00 13.32 C +ATOM 1217 O ILE A 156 27.822 69.127 53.326 1.00 18.57 O +ATOM 1218 CB ILE A 156 25.250 67.277 53.050 1.00 8.50 C +ATOM 1219 CG1 ILE A 156 24.110 68.232 52.775 1.00 8.50 C +ATOM 1220 CG2 ILE A 156 25.659 67.401 54.482 1.00 8.50 C +ATOM 1221 CD1 ILE A 156 22.868 67.901 53.537 1.00 8.74 C +ATOM 1222 N GLY A 157 26.602 69.948 51.624 1.00 12.73 N +ATOM 1223 CA GLY A 157 27.115 71.286 51.816 1.00 9.23 C +ATOM 1224 C GLY A 157 26.297 72.298 51.047 1.00 13.52 C +ATOM 1225 O GLY A 157 25.284 71.973 50.419 1.00 13.07 O +ATOM 1226 N ASN A 158 26.760 73.540 51.089 1.00 17.00 N +ATOM 1227 CA ASN A 158 26.089 74.657 50.440 1.00 10.65 C +ATOM 1228 C ASN A 158 24.605 74.765 50.728 1.00 10.03 C +ATOM 1229 O ASN A 158 23.822 75.027 49.820 1.00 13.99 O +ATOM 1230 CB ASN A 158 26.326 74.638 48.942 1.00 14.16 C +ATOM 1231 CG ASN A 158 27.602 75.297 48.568 1.00 21.88 C +ATOM 1232 OD1 ASN A 158 28.443 74.692 47.911 1.00 29.71 O +ATOM 1233 ND2 ASN A 158 27.773 76.552 48.986 1.00 26.12 N +ATOM 1234 N VAL A 159 24.211 74.558 51.982 1.00 8.83 N +ATOM 1235 CA VAL A 159 22.800 74.677 52.334 1.00 12.60 C +ATOM 1236 C VAL A 159 22.484 76.145 52.636 1.00 12.87 C +ATOM 1237 O VAL A 159 23.251 76.820 53.338 1.00 14.32 O +ATOM 1238 CB VAL A 159 22.373 73.715 53.494 1.00 8.50 C +ATOM 1239 CG1 VAL A 159 23.562 73.035 54.093 1.00 9.94 C +ATOM 1240 CG2 VAL A 159 21.576 74.439 54.550 1.00 8.50 C +ATOM 1241 N ASN A 160 21.425 76.655 52.007 1.00 8.50 N +ATOM 1242 CA ASN A 160 20.993 78.029 52.192 1.00 9.91 C +ATOM 1243 C ASN A 160 19.477 77.992 52.196 1.00 14.40 C +ATOM 1244 O ASN A 160 18.890 77.074 51.606 1.00 15.98 O +ATOM 1245 CB ASN A 160 21.482 78.918 51.048 1.00 13.60 C +ATOM 1246 CG ASN A 160 22.999 79.054 51.002 1.00 13.63 C +ATOM 1247 OD1 ASN A 160 23.668 78.376 50.231 1.00 28.91 O +ATOM 1248 ND2 ASN A 160 23.541 79.951 51.804 1.00 10.51 N +ATOM 1249 N MET A 161 18.842 78.984 52.828 1.00 10.29 N +ATOM 1250 CA MET A 161 17.388 79.026 52.915 1.00 8.50 C +ATOM 1251 C MET A 161 16.874 80.451 52.924 1.00 11.19 C +ATOM 1252 O MET A 161 17.431 81.313 53.610 1.00 14.22 O +ATOM 1253 CB MET A 161 16.939 78.312 54.195 1.00 10.34 C +ATOM 1254 CG MET A 161 15.437 78.225 54.379 1.00 16.95 C +ATOM 1255 SD MET A 161 15.014 77.165 55.730 1.00 15.83 S +ATOM 1256 CE MET A 161 13.241 76.957 55.487 1.00 8.50 C +ATOM 1257 N TRP A 162 15.835 80.704 52.136 1.00 11.60 N +ATOM 1258 CA TRP A 162 15.215 82.023 52.048 1.00 10.64 C +ATOM 1259 C TRP A 162 13.795 81.885 52.574 1.00 11.52 C +ATOM 1260 O TRP A 162 13.232 80.792 52.558 1.00 14.93 O +ATOM 1261 CB TRP A 162 15.148 82.503 50.598 1.00 8.50 C +ATOM 1262 CG TRP A 162 16.472 82.732 49.926 1.00 11.33 C +ATOM 1263 CD1 TRP A 162 17.043 83.937 49.635 1.00 12.07 C +ATOM 1264 CD2 TRP A 162 17.365 81.733 49.411 1.00 14.57 C +ATOM 1265 NE1 TRP A 162 18.229 83.755 48.972 1.00 10.35 N +ATOM 1266 CE2 TRP A 162 18.454 82.412 48.822 1.00 15.03 C +ATOM 1267 CE3 TRP A 162 17.351 80.331 49.390 1.00 8.50 C +ATOM 1268 CZ2 TRP A 162 19.522 81.735 48.219 1.00 19.26 C +ATOM 1269 CZ3 TRP A 162 18.409 79.663 48.791 1.00 10.17 C +ATOM 1270 CH2 TRP A 162 19.480 80.363 48.214 1.00 12.82 C +ATOM 1271 N ASP A 163 13.212 82.983 53.044 1.00 12.03 N +ATOM 1272 CA ASP A 163 11.835 82.948 53.546 1.00 12.91 C +ATOM 1273 C ASP A 163 10.813 83.302 52.467 1.00 15.62 C +ATOM 1274 O ASP A 163 9.631 83.529 52.763 1.00 13.58 O +ATOM 1275 CB ASP A 163 11.645 83.839 54.796 1.00 18.80 C +ATOM 1276 CG ASP A 163 11.860 85.340 54.540 1.00 16.55 C +ATOM 1277 OD1 ASP A 163 11.662 85.821 53.417 1.00 21.18 O +ATOM 1278 OD2 ASP A 163 12.195 86.060 55.500 1.00 15.67 O +ATOM 1279 N PHE A 164 11.293 83.399 51.222 1.00 14.72 N +ATOM 1280 CA PHE A 164 10.450 83.721 50.064 1.00 13.04 C +ATOM 1281 C PHE A 164 10.814 82.793 48.911 1.00 10.55 C +ATOM 1282 O PHE A 164 11.809 82.076 48.989 1.00 14.28 O +ATOM 1283 CB PHE A 164 10.594 85.201 49.648 1.00 18.42 C +ATOM 1284 CG PHE A 164 11.984 85.592 49.227 1.00 8.77 C +ATOM 1285 CD1 PHE A 164 12.926 85.991 50.164 1.00 8.50 C +ATOM 1286 CD2 PHE A 164 12.338 85.575 47.891 1.00 8.50 C +ATOM 1287 CE1 PHE A 164 14.195 86.366 49.767 1.00 11.41 C +ATOM 1288 CE2 PHE A 164 13.602 85.946 47.487 1.00 8.50 C +ATOM 1289 CZ PHE A 164 14.536 86.343 48.421 1.00 8.50 C +ATOM 1290 N VAL A 165 10.022 82.813 47.845 1.00 9.66 N +ATOM 1291 CA VAL A 165 10.258 81.937 46.706 1.00 8.50 C +ATOM 1292 C VAL A 165 11.169 82.523 45.643 1.00 8.50 C +ATOM 1293 O VAL A 165 10.835 83.509 45.006 1.00 11.88 O +ATOM 1294 CB VAL A 165 8.929 81.516 46.045 1.00 11.00 C +ATOM 1295 CG1 VAL A 165 9.181 80.487 44.960 1.00 20.39 C +ATOM 1296 CG2 VAL A 165 7.981 80.947 47.074 1.00 13.51 C +ATOM 1297 N LEU A 166 12.316 81.891 45.443 1.00 11.65 N +ATOM 1298 CA LEU A 166 13.287 82.329 44.440 1.00 9.57 C +ATOM 1299 C LEU A 166 12.704 82.165 43.042 1.00 10.67 C +ATOM 1300 O LEU A 166 11.931 81.217 42.759 1.00 10.18 O +ATOM 1301 CB LEU A 166 14.579 81.514 44.549 1.00 8.50 C +ATOM 1302 CG LEU A 166 15.789 82.121 45.245 1.00 8.50 C +ATOM 1303 CD1 LEU A 166 15.390 82.668 46.563 1.00 9.61 C +ATOM 1304 CD2 LEU A 166 16.855 81.082 45.418 1.00 8.50 C +ATOM 1305 N SER A 167 13.061 83.097 42.167 1.00 10.19 N +ATOM 1306 CA SER A 167 12.577 83.050 40.795 1.00 15.07 C +ATOM 1307 C SER A 167 13.500 82.149 39.992 1.00 15.10 C +ATOM 1308 O SER A 167 14.597 81.795 40.448 1.00 14.22 O +ATOM 1309 CB SER A 167 12.542 84.463 40.173 1.00 24.03 C +ATOM 1310 OG SER A 167 13.848 84.983 39.913 1.00 31.39 O +ATOM 1311 N PRO A 168 13.072 81.766 38.778 1.00 12.25 N +ATOM 1312 CA PRO A 168 13.889 80.911 37.925 1.00 9.71 C +ATOM 1313 C PRO A 168 15.279 81.498 37.679 1.00 13.58 C +ATOM 1314 O PRO A 168 16.278 80.780 37.685 1.00 17.90 O +ATOM 1315 CB PRO A 168 13.070 80.862 36.655 1.00 8.50 C +ATOM 1316 CG PRO A 168 11.680 80.902 37.169 1.00 8.50 C +ATOM 1317 CD PRO A 168 11.747 81.985 38.172 1.00 8.50 C +ATOM 1318 N ASP A 169 15.340 82.813 37.500 1.00 14.61 N +ATOM 1319 CA ASP A 169 16.607 83.484 37.242 1.00 17.33 C +ATOM 1320 C ASP A 169 17.509 83.445 38.464 1.00 17.43 C +ATOM 1321 O ASP A 169 18.717 83.207 38.347 1.00 22.42 O +ATOM 1322 CB ASP A 169 16.371 84.929 36.791 1.00 27.80 C +ATOM 1323 CG ASP A 169 15.552 85.017 35.499 1.00 36.92 C +ATOM 1324 OD1 ASP A 169 16.049 84.564 34.440 1.00 36.33 O +ATOM 1325 OD2 ASP A 169 14.411 85.541 35.545 1.00 41.43 O +ATOM 1326 N GLU A 170 16.921 83.656 39.638 1.00 11.86 N +ATOM 1327 CA GLU A 170 17.692 83.632 40.866 1.00 9.34 C +ATOM 1328 C GLU A 170 18.169 82.190 41.083 1.00 12.82 C +ATOM 1329 O GLU A 170 19.378 81.946 41.219 1.00 13.71 O +ATOM 1330 CB GLU A 170 16.835 84.135 42.034 1.00 11.57 C +ATOM 1331 CG GLU A 170 16.200 85.498 41.791 1.00 13.12 C +ATOM 1332 CD GLU A 170 15.427 86.013 42.987 1.00 33.29 C +ATOM 1333 OE1 GLU A 170 16.060 86.283 44.035 1.00 48.96 O +ATOM 1334 OE2 GLU A 170 14.191 86.172 42.880 1.00 34.44 O +ATOM 1335 N ILE A 171 17.241 81.229 41.009 1.00 11.18 N +ATOM 1336 CA ILE A 171 17.578 79.824 41.210 1.00 9.03 C +ATOM 1337 C ILE A 171 18.694 79.438 40.280 1.00 10.59 C +ATOM 1338 O ILE A 171 19.521 78.585 40.597 1.00 8.50 O +ATOM 1339 CB ILE A 171 16.366 78.934 40.968 1.00 8.50 C +ATOM 1340 CG1 ILE A 171 15.380 79.134 42.099 1.00 9.22 C +ATOM 1341 CG2 ILE A 171 16.775 77.476 40.872 1.00 9.69 C +ATOM 1342 CD1 ILE A 171 14.175 78.251 42.041 1.00 24.27 C +ATOM 1343 N ASN A 172 18.729 80.105 39.135 1.00 16.82 N +ATOM 1344 CA ASN A 172 19.755 79.827 38.160 1.00 20.85 C +ATOM 1345 C ASN A 172 21.102 80.365 38.600 1.00 14.77 C +ATOM 1346 O ASN A 172 22.087 79.631 38.568 1.00 17.96 O +ATOM 1347 CB ASN A 172 19.394 80.374 36.787 1.00 33.19 C +ATOM 1348 CG ASN A 172 20.386 79.942 35.729 1.00 44.44 C +ATOM 1349 OD1 ASN A 172 21.230 80.729 35.295 1.00 50.02 O +ATOM 1350 ND2 ASN A 172 20.316 78.671 35.335 1.00 46.68 N +ATOM 1351 N THR A 173 21.159 81.619 39.037 1.00 9.19 N +ATOM 1352 CA THR A 173 22.443 82.148 39.469 1.00 12.81 C +ATOM 1353 C THR A 173 22.950 81.358 40.678 1.00 12.67 C +ATOM 1354 O THR A 173 24.151 81.071 40.756 1.00 14.75 O +ATOM 1355 CB THR A 173 22.436 83.675 39.785 1.00 20.90 C +ATOM 1356 OG1 THR A 173 22.075 83.895 41.156 1.00 28.13 O +ATOM 1357 CG2 THR A 173 21.476 84.428 38.875 1.00 23.06 C +ATOM 1358 N ILE A 174 22.057 80.979 41.601 1.00 8.50 N +ATOM 1359 CA ILE A 174 22.492 80.189 42.749 1.00 8.50 C +ATOM 1360 C ILE A 174 23.229 78.948 42.231 1.00 8.67 C +ATOM 1361 O ILE A 174 24.333 78.622 42.681 1.00 10.15 O +ATOM 1362 CB ILE A 174 21.325 79.733 43.627 1.00 8.50 C +ATOM 1363 CG1 ILE A 174 20.928 80.831 44.589 1.00 10.75 C +ATOM 1364 CG2 ILE A 174 21.735 78.565 44.478 1.00 10.89 C +ATOM 1365 CD1 ILE A 174 20.123 81.891 43.979 1.00 24.77 C +ATOM 1366 N TYR A 175 22.639 78.285 41.248 1.00 8.50 N +ATOM 1367 CA TYR A 175 23.244 77.094 40.681 1.00 10.78 C +ATOM 1368 C TYR A 175 24.600 77.357 40.029 1.00 18.01 C +ATOM 1369 O TYR A 175 25.590 76.663 40.306 1.00 20.08 O +ATOM 1370 CB TYR A 175 22.304 76.439 39.662 1.00 8.50 C +ATOM 1371 CG TYR A 175 22.929 75.255 38.951 1.00 9.51 C +ATOM 1372 CD1 TYR A 175 23.501 74.213 39.668 1.00 17.85 C +ATOM 1373 CD2 TYR A 175 22.955 75.180 37.567 1.00 21.23 C +ATOM 1374 CE1 TYR A 175 24.083 73.127 39.030 1.00 22.76 C +ATOM 1375 CE2 TYR A 175 23.535 74.091 36.912 1.00 30.97 C +ATOM 1376 CZ TYR A 175 24.093 73.067 37.651 1.00 28.96 C +ATOM 1377 OH TYR A 175 24.631 71.969 37.011 1.00 43.52 O +ATOM 1378 N LEU A 176 24.617 78.352 39.147 1.00 20.97 N +ATOM 1379 CA LEU A 176 25.810 78.741 38.400 1.00 22.61 C +ATOM 1380 C LEU A 176 26.917 79.388 39.214 1.00 26.70 C +ATOM 1381 O LEU A 176 28.000 79.647 38.682 1.00 27.93 O +ATOM 1382 CB LEU A 176 25.424 79.673 37.256 1.00 21.79 C +ATOM 1383 CG LEU A 176 25.432 79.066 35.855 1.00 21.20 C +ATOM 1384 CD1 LEU A 176 25.341 77.546 35.891 1.00 25.78 C +ATOM 1385 CD2 LEU A 176 24.278 79.669 35.067 1.00 28.56 C +ATOM 1386 N GLY A 177 26.639 79.674 40.482 1.00 28.76 N +ATOM 1387 CA GLY A 177 27.640 80.289 41.328 1.00 34.01 C +ATOM 1388 C GLY A 177 27.672 81.794 41.173 1.00 37.14 C +ATOM 1389 O GLY A 177 28.694 82.377 40.802 1.00 45.53 O +ATOM 1390 N GLY A 178 26.524 82.421 41.392 1.00 39.32 N +ATOM 1391 CA GLY A 178 26.457 83.864 41.304 1.00 38.80 C +ATOM 1392 C GLY A 178 26.404 84.382 42.727 1.00 39.95 C +ATOM 1393 O GLY A 178 26.552 83.603 43.680 1.00 40.94 O +ATOM 1394 N PRO A 179 26.283 85.700 42.912 1.00 36.18 N +ATOM 1395 CA PRO A 179 26.221 86.250 44.264 1.00 34.30 C +ATOM 1396 C PRO A 179 24.772 86.405 44.686 1.00 31.11 C +ATOM 1397 O PRO A 179 23.936 86.809 43.885 1.00 32.37 O +ATOM 1398 CB PRO A 179 26.919 87.595 44.101 1.00 40.70 C +ATOM 1399 CG PRO A 179 26.496 88.017 42.735 1.00 30.98 C +ATOM 1400 CD PRO A 179 26.555 86.755 41.915 1.00 32.25 C +ATOM 1401 N PHE A 180 24.483 86.089 45.945 1.00 30.92 N +ATOM 1402 CA PHE A 180 23.124 86.185 46.489 1.00 28.09 C +ATOM 1403 C PHE A 180 23.196 86.287 48.006 1.00 27.93 C +ATOM 1404 O PHE A 180 24.252 86.024 48.598 1.00 29.29 O +ATOM 1405 CB PHE A 180 22.310 84.949 46.101 1.00 25.71 C +ATOM 1406 CG PHE A 180 23.002 83.658 46.407 1.00 29.37 C +ATOM 1407 CD1 PHE A 180 23.899 83.101 45.495 1.00 42.30 C +ATOM 1408 CD2 PHE A 180 22.810 83.023 47.623 1.00 33.47 C +ATOM 1409 CE1 PHE A 180 24.602 81.928 45.794 1.00 40.42 C +ATOM 1410 CE2 PHE A 180 23.509 81.849 47.936 1.00 43.59 C +ATOM 1411 CZ PHE A 180 24.409 81.303 47.016 1.00 43.51 C +ATOM 1412 N SER A 181 22.073 86.640 48.628 1.00 25.95 N +ATOM 1413 CA SER A 181 22.013 86.762 50.078 1.00 30.77 C +ATOM 1414 C SER A 181 20.793 86.078 50.695 1.00 30.02 C +ATOM 1415 O SER A 181 19.670 86.583 50.588 1.00 38.30 O +ATOM 1416 CB SER A 181 22.057 88.237 50.503 1.00 38.13 C +ATOM 1417 OG SER A 181 23.265 88.542 51.204 1.00 52.99 O +ATOM 1418 N PRO A 182 20.993 84.890 51.308 1.00 24.79 N +ATOM 1419 CA PRO A 182 19.915 84.128 51.948 1.00 23.11 C +ATOM 1420 C PRO A 182 19.463 84.943 53.157 1.00 24.53 C +ATOM 1421 O PRO A 182 20.206 85.821 53.610 1.00 29.46 O +ATOM 1422 CB PRO A 182 20.630 82.858 52.403 1.00 17.69 C +ATOM 1423 CG PRO A 182 21.784 82.750 51.492 1.00 13.81 C +ATOM 1424 CD PRO A 182 22.263 84.155 51.418 1.00 20.84 C +ATOM 1425 N ASN A 183 18.279 84.665 53.695 1.00 20.04 N +ATOM 1426 CA ASN A 183 17.828 85.423 54.856 1.00 13.41 C +ATOM 1427 C ASN A 183 17.242 84.577 55.970 1.00 14.95 C +ATOM 1428 O ASN A 183 16.433 85.056 56.758 1.00 24.25 O +ATOM 1429 CB ASN A 183 16.867 86.546 54.447 1.00 11.01 C +ATOM 1430 CG ASN A 183 15.529 86.036 53.956 1.00 14.74 C +ATOM 1431 OD1 ASN A 183 15.343 84.850 53.706 1.00 26.42 O +ATOM 1432 ND2 ASN A 183 14.588 86.942 53.803 1.00 20.68 N +ATOM 1433 N VAL A 184 17.624 83.303 56.006 1.00 14.86 N +ATOM 1434 CA VAL A 184 17.182 82.362 57.046 1.00 10.81 C +ATOM 1435 C VAL A 184 18.425 81.542 57.384 1.00 12.58 C +ATOM 1436 O VAL A 184 18.960 81.646 58.476 1.00 19.25 O +ATOM 1437 CB VAL A 184 16.023 81.421 56.581 1.00 8.50 C +ATOM 1438 CG1 VAL A 184 15.650 80.478 57.672 1.00 9.23 C +ATOM 1439 CG2 VAL A 184 14.810 82.209 56.210 1.00 8.50 C +ATOM 1440 N LEU A 185 18.914 80.761 56.427 1.00 13.77 N +ATOM 1441 CA LEU A 185 20.108 79.940 56.630 1.00 12.04 C +ATOM 1442 C LEU A 185 21.096 80.455 55.627 1.00 13.20 C +ATOM 1443 O LEU A 185 20.755 80.596 54.458 1.00 16.80 O +ATOM 1444 CB LEU A 185 19.808 78.462 56.358 1.00 17.10 C +ATOM 1445 CG LEU A 185 19.846 77.518 57.566 1.00 14.49 C +ATOM 1446 CD1 LEU A 185 19.032 78.082 58.682 1.00 8.50 C +ATOM 1447 CD2 LEU A 185 19.295 76.154 57.184 1.00 17.73 C +ATOM 1448 N ASN A 186 22.304 80.767 56.080 1.00 16.17 N +ATOM 1449 CA ASN A 186 23.341 81.306 55.204 1.00 11.86 C +ATOM 1450 C ASN A 186 24.619 80.510 55.373 1.00 12.81 C +ATOM 1451 O ASN A 186 25.229 80.539 56.432 1.00 17.48 O +ATOM 1452 CB ASN A 186 23.583 82.778 55.560 1.00 20.78 C +ATOM 1453 CG ASN A 186 24.530 83.488 54.595 1.00 21.95 C +ATOM 1454 OD1 ASN A 186 25.393 82.871 53.979 1.00 22.39 O +ATOM 1455 ND2 ASN A 186 24.386 84.801 54.488 1.00 26.06 N +ATOM 1456 N TRP A 187 25.035 79.820 54.320 1.00 12.27 N +ATOM 1457 CA TRP A 187 26.240 79.001 54.362 1.00 10.14 C +ATOM 1458 C TRP A 187 27.502 79.821 54.611 1.00 12.46 C +ATOM 1459 O TRP A 187 28.525 79.282 55.025 1.00 19.10 O +ATOM 1460 CB TRP A 187 26.366 78.194 53.071 1.00 8.50 C +ATOM 1461 CG TRP A 187 27.328 77.040 53.140 1.00 8.50 C +ATOM 1462 CD1 TRP A 187 28.506 76.914 52.464 1.00 15.22 C +ATOM 1463 CD2 TRP A 187 27.171 75.834 53.892 1.00 10.17 C +ATOM 1464 NE1 TRP A 187 29.092 75.705 52.745 1.00 18.58 N +ATOM 1465 CE2 TRP A 187 28.295 75.021 53.618 1.00 13.56 C +ATOM 1466 CE3 TRP A 187 26.189 75.359 54.766 1.00 8.50 C +ATOM 1467 CZ2 TRP A 187 28.463 73.762 54.184 1.00 11.62 C +ATOM 1468 CZ3 TRP A 187 26.354 74.116 55.324 1.00 8.50 C +ATOM 1469 CH2 TRP A 187 27.486 73.327 55.032 1.00 11.85 C +ATOM 1470 N ARG A 188 27.440 81.120 54.359 1.00 10.48 N +ATOM 1471 CA ARG A 188 28.599 81.970 54.575 1.00 21.01 C +ATOM 1472 C ARG A 188 28.682 82.496 56.020 1.00 27.51 C +ATOM 1473 O ARG A 188 29.742 82.954 56.471 1.00 31.67 O +ATOM 1474 CB ARG A 188 28.660 83.065 53.511 1.00 39.85 C +ATOM 1475 CG ARG A 188 29.109 82.560 52.111 1.00 55.66 C +ATOM 1476 CD ARG A 188 28.494 83.412 50.968 1.00 78.41 C +ATOM 1477 NE ARG A 188 29.174 83.282 49.672 1.00 79.64 N +ATOM 1478 CZ ARG A 188 28.773 83.875 48.544 1.00 84.85 C +ATOM 1479 NH1 ARG A 188 27.681 84.639 48.528 1.00 83.07 N +ATOM 1480 NH2 ARG A 188 29.500 83.747 47.436 1.00 84.36 N +ATOM 1481 N ALA A 189 27.576 82.375 56.751 1.00 25.43 N +ATOM 1482 CA ALA A 189 27.496 82.793 58.147 1.00 19.58 C +ATOM 1483 C ALA A 189 26.654 81.718 58.840 1.00 22.08 C +ATOM 1484 O ALA A 189 25.597 82.001 59.405 1.00 24.64 O +ATOM 1485 CB ALA A 189 26.815 84.146 58.248 1.00 11.92 C +ATOM 1486 N LEU A 190 27.110 80.471 58.745 1.00 20.47 N +ATOM 1487 CA LEU A 190 26.389 79.347 59.329 1.00 22.47 C +ATOM 1488 C LEU A 190 26.669 79.240 60.821 1.00 27.17 C +ATOM 1489 O LEU A 190 27.798 79.493 61.276 1.00 29.20 O +ATOM 1490 CB LEU A 190 26.781 78.033 58.634 1.00 14.44 C +ATOM 1491 CG LEU A 190 25.811 76.861 58.816 1.00 8.50 C +ATOM 1492 CD1 LEU A 190 24.590 77.046 57.928 1.00 8.50 C +ATOM 1493 CD2 LEU A 190 26.505 75.568 58.487 1.00 8.50 C +ATOM 1494 N LYS A 191 25.626 78.925 61.590 1.00 32.15 N +ATOM 1495 CA LYS A 191 25.736 78.755 63.037 1.00 29.29 C +ATOM 1496 C LYS A 191 25.243 77.339 63.258 1.00 24.05 C +ATOM 1497 O LYS A 191 24.049 77.073 63.192 1.00 20.12 O +ATOM 1498 CB LYS A 191 24.849 79.774 63.758 1.00 37.68 C +ATOM 1499 CG LYS A 191 25.342 80.145 65.152 1.00 62.01 C +ATOM 1500 CD LYS A 191 24.754 81.480 65.612 1.00 80.32 C +ATOM 1501 CE LYS A 191 25.290 81.896 66.984 1.00 92.06 C +ATOM 1502 NZ LYS A 191 24.853 83.275 67.376 1.00 94.62 N +ATOM 1503 N TYR A 192 26.175 76.423 63.473 1.00 23.35 N +ATOM 1504 CA TYR A 192 25.812 75.028 63.629 1.00 25.88 C +ATOM 1505 C TYR A 192 26.451 74.373 64.849 1.00 33.68 C +ATOM 1506 O TYR A 192 27.261 74.982 65.560 1.00 40.30 O +ATOM 1507 CB TYR A 192 26.239 74.263 62.370 1.00 18.41 C +ATOM 1508 CG TYR A 192 27.736 74.287 62.143 1.00 8.50 C +ATOM 1509 CD1 TYR A 192 28.371 75.436 61.685 1.00 22.27 C +ATOM 1510 CD2 TYR A 192 28.518 73.182 62.417 1.00 8.50 C +ATOM 1511 CE1 TYR A 192 29.755 75.484 61.507 1.00 20.88 C +ATOM 1512 CE2 TYR A 192 29.896 73.214 62.251 1.00 15.32 C +ATOM 1513 CZ TYR A 192 30.515 74.366 61.796 1.00 21.96 C +ATOM 1514 OH TYR A 192 31.897 74.395 61.643 1.00 33.31 O +ATOM 1515 N GLU A 193 26.123 73.099 65.041 1.00 36.55 N +ATOM 1516 CA GLU A 193 26.646 72.296 66.136 1.00 36.71 C +ATOM 1517 C GLU A 193 26.761 70.863 65.598 1.00 36.82 C +ATOM 1518 O GLU A 193 25.781 70.286 65.105 1.00 35.46 O +ATOM 1519 CB GLU A 193 25.675 72.352 67.303 1.00 49.53 C +ATOM 1520 CG GLU A 193 26.243 71.902 68.631 1.00 71.07 C +ATOM 1521 CD GLU A 193 25.226 72.038 69.747 1.00 83.63 C +ATOM 1522 OE1 GLU A 193 24.411 71.097 69.918 1.00 87.16 O +ATOM 1523 OE2 GLU A 193 25.235 73.092 70.433 1.00 90.10 O +ATOM 1524 N VAL A 194 27.977 70.327 65.628 1.00 34.80 N +ATOM 1525 CA VAL A 194 28.251 68.985 65.136 1.00 32.93 C +ATOM 1526 C VAL A 194 28.082 67.968 66.260 1.00 35.56 C +ATOM 1527 O VAL A 194 28.329 68.278 67.428 1.00 40.53 O +ATOM 1528 CB VAL A 194 29.695 68.911 64.574 1.00 33.45 C +ATOM 1529 CG1 VAL A 194 30.070 67.487 64.204 1.00 39.43 C +ATOM 1530 CG2 VAL A 194 29.818 69.798 63.362 1.00 39.24 C +ATOM 1531 N GLN A 195 27.666 66.755 65.907 1.00 35.83 N +ATOM 1532 CA GLN A 195 27.476 65.703 66.887 1.00 33.13 C +ATOM 1533 C GLN A 195 27.791 64.366 66.257 1.00 27.97 C +ATOM 1534 O GLN A 195 27.177 63.989 65.261 1.00 31.43 O +ATOM 1535 CB GLN A 195 26.025 65.690 67.369 1.00 45.59 C +ATOM 1536 CG GLN A 195 25.856 65.208 68.796 1.00 63.03 C +ATOM 1537 CD GLN A 195 26.483 66.165 69.795 1.00 72.16 C +ATOM 1538 OE1 GLN A 195 27.424 65.809 70.507 1.00 76.33 O +ATOM 1539 NE2 GLN A 195 25.966 67.393 69.847 1.00 75.17 N +ATOM 1540 N GLY A 196 28.774 63.669 66.808 1.00 23.42 N +ATOM 1541 CA GLY A 196 29.106 62.359 66.293 1.00 26.09 C +ATOM 1542 C GLY A 196 30.238 62.325 65.306 1.00 28.68 C +ATOM 1543 O GLY A 196 31.109 63.190 65.320 1.00 34.08 O +ATOM 1544 N GLU A 197 30.200 61.323 64.433 1.00 27.28 N +ATOM 1545 CA GLU A 197 31.232 61.112 63.435 1.00 21.59 C +ATOM 1546 C GLU A 197 31.027 61.950 62.171 1.00 23.01 C +ATOM 1547 O GLU A 197 30.675 61.414 61.116 1.00 31.51 O +ATOM 1548 CB GLU A 197 31.278 59.628 63.078 1.00 25.52 C +ATOM 1549 CG GLU A 197 32.515 59.185 62.305 1.00 36.26 C +ATOM 1550 CD GLU A 197 33.657 58.750 63.202 1.00 40.72 C +ATOM 1551 OE1 GLU A 197 33.705 59.182 64.386 1.00 39.41 O +ATOM 1552 OE2 GLU A 197 34.507 57.967 62.708 1.00 41.14 O +ATOM 1553 N VAL A 198 31.204 63.261 62.281 1.00 16.02 N +ATOM 1554 CA VAL A 198 31.066 64.138 61.124 1.00 14.09 C +ATOM 1555 C VAL A 198 32.244 65.099 61.095 1.00 15.22 C +ATOM 1556 O VAL A 198 32.623 65.651 62.129 1.00 19.42 O +ATOM 1557 CB VAL A 198 29.676 64.870 61.070 1.00 16.41 C +ATOM 1558 CG1 VAL A 198 28.933 64.732 62.375 1.00 12.74 C +ATOM 1559 CG2 VAL A 198 29.838 66.333 60.689 1.00 11.55 C +ATOM 1560 N PHE A 199 32.860 65.227 59.922 1.00 14.26 N +ATOM 1561 CA PHE A 199 34.028 66.091 59.732 1.00 14.88 C +ATOM 1562 C PHE A 199 33.756 67.171 58.708 1.00 17.39 C +ATOM 1563 O PHE A 199 32.826 67.056 57.900 1.00 23.58 O +ATOM 1564 CB PHE A 199 35.231 65.282 59.241 1.00 14.67 C +ATOM 1565 CG PHE A 199 35.457 64.017 60.004 1.00 23.99 C +ATOM 1566 CD1 PHE A 199 34.747 62.851 59.687 1.00 19.86 C +ATOM 1567 CD2 PHE A 199 36.369 63.988 61.053 1.00 26.88 C +ATOM 1568 CE1 PHE A 199 34.950 61.676 60.413 1.00 24.55 C +ATOM 1569 CE2 PHE A 199 36.575 62.813 61.783 1.00 28.30 C +ATOM 1570 CZ PHE A 199 35.863 61.654 61.463 1.00 22.97 C +ATOM 1571 N THR A 200 34.610 68.192 58.710 1.00 16.07 N +ATOM 1572 CA THR A 200 34.498 69.315 57.781 1.00 13.99 C +ATOM 1573 C THR A 200 35.688 69.211 56.852 1.00 12.36 C +ATOM 1574 O THR A 200 36.825 69.309 57.295 1.00 20.65 O +ATOM 1575 CB THR A 200 34.543 70.676 58.528 1.00 11.72 C +ATOM 1576 OG1 THR A 200 33.491 70.724 59.506 1.00 31.87 O +ATOM 1577 CG2 THR A 200 34.345 71.812 57.575 1.00 12.29 C +ATOM 1578 N LYS A 201 35.422 68.948 55.578 1.00 15.58 N +ATOM 1579 CA LYS A 201 36.476 68.825 54.566 1.00 12.53 C +ATOM 1580 C LYS A 201 36.144 69.698 53.336 1.00 10.67 C +ATOM 1581 O LYS A 201 35.030 70.241 53.228 1.00 8.50 O +ATOM 1582 CB LYS A 201 36.642 67.349 54.149 1.00 10.09 C +ATOM 1583 CG LYS A 201 37.192 66.428 55.235 1.00 18.02 C +ATOM 1584 CD LYS A 201 38.490 66.968 55.853 1.00 26.23 C +ATOM 1585 CE LYS A 201 39.361 65.847 56.435 1.00 21.62 C +ATOM 1586 NZ LYS A 201 39.923 64.982 55.358 1.00 24.57 N +ATOM 1587 N PRO A 202 37.123 69.894 52.428 1.00 8.76 N +ATOM 1588 CA PRO A 202 36.922 70.696 51.219 1.00 8.89 C +ATOM 1589 C PRO A 202 35.887 70.023 50.316 1.00 12.77 C +ATOM 1590 O PRO A 202 35.948 68.818 50.114 1.00 20.74 O +ATOM 1591 CB PRO A 202 38.301 70.656 50.562 1.00 8.50 C +ATOM 1592 CG PRO A 202 39.219 70.482 51.698 1.00 8.50 C +ATOM 1593 CD PRO A 202 38.523 69.450 52.508 1.00 8.50 C +ATOM 1594 N GLN A 203 34.973 70.788 49.737 1.00 8.50 N +ATOM 1595 CA GLN A 203 33.941 70.209 48.889 1.00 8.50 C +ATOM 1596 C GLN A 203 34.484 69.588 47.621 1.00 10.86 C +ATOM 1597 O GLN A 203 35.418 70.128 47.011 1.00 12.33 O +ATOM 1598 CB GLN A 203 32.892 71.254 48.535 1.00 13.21 C +ATOM 1599 CG GLN A 203 33.436 72.460 47.824 1.00 13.56 C +ATOM 1600 CD GLN A 203 32.348 73.420 47.458 1.00 19.33 C +ATOM 1601 OE1 GLN A 203 32.273 73.876 46.329 1.00 35.34 O +ATOM 1602 NE2 GLN A 203 31.487 73.736 48.416 1.00 28.23 N +ATOM 1603 N LEU A 204 33.864 68.479 47.209 1.00 11.86 N +ATOM 1604 CA LEU A 204 34.278 67.756 46.006 1.00 9.58 C +ATOM 1605 C LEU A 204 33.645 68.297 44.748 1.00 11.91 C +ATOM 1606 O LEU A 204 34.193 68.114 43.661 1.00 14.38 O +ATOM 1607 CB LEU A 204 33.961 66.281 46.124 1.00 14.60 C +ATOM 1608 CG LEU A 204 34.502 65.659 47.396 1.00 14.98 C +ATOM 1609 CD1 LEU A 204 33.364 65.657 48.411 1.00 24.26 C +ATOM 1610 CD2 LEU A 204 35.000 64.255 47.130 1.00 8.50 C +ATOM 1611 N TRP A 205 32.443 68.863 44.882 1.00 15.88 N +ATOM 1612 CA TRP A 205 31.759 69.464 43.738 1.00 20.16 C +ATOM 1613 C TRP A 205 32.401 70.822 43.541 1.00 26.07 C +ATOM 1614 O TRP A 205 32.909 71.403 44.500 1.00 36.34 O +ATOM 1615 CB TRP A 205 30.258 69.626 43.974 1.00 14.78 C +ATOM 1616 CG TRP A 205 29.903 70.120 45.317 1.00 16.14 C +ATOM 1617 CD1 TRP A 205 29.802 71.420 45.716 1.00 13.53 C +ATOM 1618 CD2 TRP A 205 29.578 69.315 46.458 1.00 19.83 C +ATOM 1619 NE1 TRP A 205 29.431 71.476 47.039 1.00 22.84 N +ATOM 1620 CE2 TRP A 205 29.284 70.197 47.516 1.00 21.91 C +ATOM 1621 CE3 TRP A 205 29.505 67.933 46.686 1.00 9.65 C +ATOM 1622 CZ2 TRP A 205 28.920 69.744 48.776 1.00 23.41 C +ATOM 1623 CZ3 TRP A 205 29.146 67.493 47.931 1.00 18.30 C +ATOM 1624 CH2 TRP A 205 28.857 68.392 48.963 1.00 20.18 C +ATOM 1625 N PRO A 206 32.453 71.307 42.293 1.00 26.63 N +ATOM 1626 CA PRO A 206 33.052 72.603 41.988 1.00 29.21 C +ATOM 1627 C PRO A 206 32.125 73.784 42.295 1.00 36.39 C +ATOM 1628 O PRO A 206 32.672 74.865 42.608 1.00 40.83 O +ATOM 1629 CB PRO A 206 33.340 72.478 40.507 1.00 30.81 C +ATOM 1630 CG PRO A 206 32.153 71.680 40.025 1.00 33.02 C +ATOM 1631 CD PRO A 206 32.046 70.611 41.060 1.00 30.13 C +ATOM 1632 OXT PRO A 206 30.879 73.623 42.219 1.00 41.44 O +TER 1633 PRO A 206 +ATOM 1634 N GLN B 1 67.492 58.090 40.504 1.00 61.78 N +ATOM 1635 CA GLN B 1 67.472 59.550 40.223 1.00 54.39 C +ATOM 1636 C GLN B 1 67.365 59.697 38.714 1.00 53.94 C +ATOM 1637 O GLN B 1 68.277 60.204 38.054 1.00 60.68 O +ATOM 1638 CB GLN B 1 68.753 60.218 40.744 1.00 65.36 C +ATOM 1639 CG GLN B 1 68.631 61.730 41.013 1.00 83.15 C +ATOM 1640 CD GLN B 1 67.695 62.057 42.181 1.00 86.76 C +ATOM 1641 OE1 GLN B 1 66.582 61.539 42.254 1.00 93.26 O +ATOM 1642 NE2 GLN B 1 68.149 62.908 43.098 1.00 77.35 N +ATOM 1643 N THR B 2 66.258 59.215 38.167 1.00 43.96 N +ATOM 1644 CA THR B 2 66.055 59.284 36.733 1.00 36.91 C +ATOM 1645 C THR B 2 64.804 60.098 36.461 1.00 35.60 C +ATOM 1646 O THR B 2 63.823 59.997 37.204 1.00 38.96 O +ATOM 1647 CB THR B 2 65.889 57.873 36.152 1.00 35.72 C +ATOM 1648 OG1 THR B 2 66.938 57.026 36.647 1.00 43.58 O +ATOM 1649 CG2 THR B 2 65.942 57.911 34.632 1.00 44.36 C +ATOM 1650 N ASP B 3 64.859 60.957 35.447 1.00 32.47 N +ATOM 1651 CA ASP B 3 63.694 61.753 35.098 1.00 25.97 C +ATOM 1652 C ASP B 3 62.837 60.872 34.189 1.00 26.29 C +ATOM 1653 O ASP B 3 63.099 60.732 32.987 1.00 27.20 O +ATOM 1654 CB ASP B 3 64.106 63.042 34.383 1.00 30.05 C +ATOM 1655 CG ASP B 3 63.000 64.086 34.385 1.00 33.34 C +ATOM 1656 OD1 ASP B 3 61.844 63.740 34.714 1.00 28.65 O +ATOM 1657 OD2 ASP B 3 63.285 65.261 34.074 1.00 38.74 O +ATOM 1658 N MET B 4 61.836 60.246 34.788 1.00 21.22 N +ATOM 1659 CA MET B 4 60.953 59.355 34.060 1.00 19.65 C +ATOM 1660 C MET B 4 59.859 60.069 33.277 1.00 18.32 C +ATOM 1661 O MET B 4 58.904 59.431 32.801 1.00 16.33 O +ATOM 1662 CB MET B 4 60.339 58.332 35.017 1.00 19.33 C +ATOM 1663 CG MET B 4 61.330 57.290 35.501 1.00 14.60 C +ATOM 1664 SD MET B 4 62.059 56.448 34.091 1.00 28.83 S +ATOM 1665 CE MET B 4 60.767 55.237 33.752 1.00 18.06 C +ATOM 1666 N SER B 5 60.027 61.378 33.101 1.00 14.03 N +ATOM 1667 CA SER B 5 59.060 62.200 32.370 1.00 16.89 C +ATOM 1668 C SER B 5 58.778 61.706 30.964 1.00 18.12 C +ATOM 1669 O SER B 5 59.707 61.406 30.205 1.00 25.49 O +ATOM 1670 CB SER B 5 59.543 63.651 32.291 1.00 19.01 C +ATOM 1671 OG SER B 5 59.367 64.312 33.535 1.00 31.95 O +ATOM 1672 N ARG B 6 57.492 61.662 30.625 1.00 16.31 N +ATOM 1673 CA ARG B 6 57.023 61.220 29.318 1.00 14.99 C +ATOM 1674 C ARG B 6 57.303 59.743 29.023 1.00 16.24 C +ATOM 1675 O ARG B 6 57.152 59.280 27.885 1.00 20.57 O +ATOM 1676 CB ARG B 6 57.532 62.150 28.223 1.00 18.20 C +ATOM 1677 CG ARG B 6 56.856 63.500 28.260 1.00 29.20 C +ATOM 1678 CD ARG B 6 55.334 63.362 28.119 1.00 35.47 C +ATOM 1679 NE ARG B 6 54.635 64.579 28.537 1.00 43.03 N +ATOM 1680 CZ ARG B 6 53.473 64.999 28.047 1.00 36.19 C +ATOM 1681 NH1 ARG B 6 52.846 64.314 27.101 1.00 30.26 N +ATOM 1682 NH2 ARG B 6 52.926 66.100 28.533 1.00 41.85 N +ATOM 1683 N LYS B 7 57.647 58.995 30.071 1.00 13.43 N +ATOM 1684 CA LYS B 7 57.925 57.578 29.945 1.00 12.59 C +ATOM 1685 C LYS B 7 56.965 56.712 30.780 1.00 13.69 C +ATOM 1686 O LYS B 7 56.263 57.208 31.683 1.00 8.78 O +ATOM 1687 CB LYS B 7 59.384 57.313 30.315 1.00 11.47 C +ATOM 1688 CG LYS B 7 60.358 57.825 29.268 1.00 17.86 C +ATOM 1689 CD LYS B 7 61.757 57.939 29.809 1.00 34.45 C +ATOM 1690 CE LYS B 7 62.705 58.517 28.780 1.00 38.70 C +ATOM 1691 NZ LYS B 7 64.012 58.844 29.417 1.00 59.02 N +ATOM 1692 N ALA B 8 56.913 55.426 30.444 1.00 10.12 N +ATOM 1693 CA ALA B 8 56.054 54.486 31.134 1.00 9.65 C +ATOM 1694 C ALA B 8 56.743 53.138 31.132 1.00 10.03 C +ATOM 1695 O ALA B 8 57.542 52.854 30.243 1.00 10.88 O +ATOM 1696 CB ALA B 8 54.703 54.383 30.424 1.00 9.11 C +ATOM 1697 N PHE B 9 56.508 52.352 32.178 1.00 12.33 N +ATOM 1698 CA PHE B 9 57.071 51.013 32.264 1.00 11.57 C +ATOM 1699 C PHE B 9 56.027 50.161 31.549 1.00 11.03 C +ATOM 1700 O PHE B 9 54.819 50.363 31.751 1.00 8.72 O +ATOM 1701 CB PHE B 9 57.173 50.547 33.723 1.00 15.68 C +ATOM 1702 CG PHE B 9 58.216 51.260 34.539 1.00 9.77 C +ATOM 1703 CD1 PHE B 9 59.554 51.215 34.180 1.00 8.50 C +ATOM 1704 CD2 PHE B 9 57.858 51.923 35.707 1.00 10.21 C +ATOM 1705 CE1 PHE B 9 60.520 51.817 34.980 1.00 12.71 C +ATOM 1706 CE2 PHE B 9 58.816 52.527 36.508 1.00 8.70 C +ATOM 1707 CZ PHE B 9 60.149 52.473 36.144 1.00 10.33 C +ATOM 1708 N VAL B 10 56.475 49.236 30.708 1.00 9.25 N +ATOM 1709 CA VAL B 10 55.546 48.380 29.996 1.00 11.60 C +ATOM 1710 C VAL B 10 55.850 46.886 30.162 1.00 11.25 C +ATOM 1711 O VAL B 10 56.962 46.430 29.885 1.00 9.92 O +ATOM 1712 CB VAL B 10 55.419 48.814 28.506 1.00 15.20 C +ATOM 1713 CG1 VAL B 10 56.718 49.415 28.013 1.00 8.50 C +ATOM 1714 CG2 VAL B 10 54.983 47.647 27.625 1.00 14.97 C +ATOM 1715 N PHE B 11 54.867 46.163 30.701 1.00 11.05 N +ATOM 1716 CA PHE B 11 54.928 44.713 30.943 1.00 11.72 C +ATOM 1717 C PHE B 11 54.118 44.071 29.815 1.00 13.67 C +ATOM 1718 O PHE B 11 52.894 43.898 29.941 1.00 16.24 O +ATOM 1719 CB PHE B 11 54.263 44.378 32.298 1.00 10.71 C +ATOM 1720 CG PHE B 11 54.804 45.173 33.457 1.00 20.19 C +ATOM 1721 CD1 PHE B 11 55.918 44.731 34.174 1.00 19.85 C +ATOM 1722 CD2 PHE B 11 54.218 46.382 33.820 1.00 16.81 C +ATOM 1723 CE1 PHE B 11 56.441 45.486 35.231 1.00 15.97 C +ATOM 1724 CE2 PHE B 11 54.740 47.132 34.873 1.00 13.11 C +ATOM 1725 CZ PHE B 11 55.856 46.681 35.578 1.00 9.00 C +ATOM 1726 N PRO B 12 54.781 43.682 28.716 1.00 8.50 N +ATOM 1727 CA PRO B 12 54.174 43.067 27.532 1.00 10.45 C +ATOM 1728 C PRO B 12 53.461 41.734 27.687 1.00 18.68 C +ATOM 1729 O PRO B 12 52.530 41.446 26.945 1.00 26.11 O +ATOM 1730 CB PRO B 12 55.346 42.944 26.566 1.00 8.50 C +ATOM 1731 CG PRO B 12 56.309 43.954 27.058 1.00 12.24 C +ATOM 1732 CD PRO B 12 56.227 43.792 28.543 1.00 8.50 C +ATOM 1733 N LYS B 13 53.931 40.885 28.589 1.00 30.21 N +ATOM 1734 CA LYS B 13 53.287 39.586 28.769 1.00 34.44 C +ATOM 1735 C LYS B 13 53.123 39.118 30.212 1.00 35.65 C +ATOM 1736 O LYS B 13 53.842 39.573 31.128 1.00 32.06 O +ATOM 1737 CB LYS B 13 53.964 38.505 27.910 1.00 36.23 C +ATOM 1738 CG LYS B 13 55.495 38.458 27.938 1.00 37.46 C +ATOM 1739 CD LYS B 13 55.975 37.469 26.882 1.00 52.27 C +ATOM 1740 CE LYS B 13 57.487 37.478 26.698 1.00 63.66 C +ATOM 1741 NZ LYS B 13 58.235 37.016 27.907 1.00 73.08 N +ATOM 1742 N GLU B 14 52.155 38.220 30.396 1.00 35.65 N +ATOM 1743 CA GLU B 14 51.836 37.669 31.708 1.00 42.94 C +ATOM 1744 C GLU B 14 53.048 36.960 32.283 1.00 44.92 C +ATOM 1745 O GLU B 14 53.583 36.017 31.682 1.00 45.61 O +ATOM 1746 CB GLU B 14 50.642 36.709 31.627 1.00 45.30 C +ATOM 1747 CG GLU B 14 50.107 36.269 32.993 1.00 53.34 C +ATOM 1748 CD GLU B 14 48.847 35.391 32.906 1.00 58.74 C +ATOM 1749 OE1 GLU B 14 47.793 35.898 32.456 1.00 61.06 O +ATOM 1750 OE2 GLU B 14 48.898 34.202 33.309 1.00 51.49 O +ATOM 1751 N SER B 15 53.497 37.441 33.437 1.00 47.87 N +ATOM 1752 CA SER B 15 54.660 36.867 34.083 1.00 44.93 C +ATOM 1753 C SER B 15 54.469 36.561 35.560 1.00 43.67 C +ATOM 1754 O SER B 15 53.438 36.861 36.175 1.00 40.68 O +ATOM 1755 CB SER B 15 55.897 37.755 33.859 1.00 47.20 C +ATOM 1756 OG SER B 15 55.646 39.109 34.203 1.00 53.11 O +ATOM 1757 N ASP B 16 55.485 35.902 36.089 1.00 46.38 N +ATOM 1758 CA ASP B 16 55.558 35.473 37.467 1.00 46.77 C +ATOM 1759 C ASP B 16 56.798 36.183 38.018 1.00 43.03 C +ATOM 1760 O ASP B 16 56.952 36.354 39.227 1.00 42.20 O +ATOM 1761 CB ASP B 16 55.799 33.950 37.445 1.00 55.52 C +ATOM 1762 CG ASP B 16 55.351 33.246 38.717 1.00 70.96 C +ATOM 1763 OD1 ASP B 16 54.472 33.773 39.440 1.00 84.15 O +ATOM 1764 OD2 ASP B 16 55.869 32.138 38.981 1.00 70.69 O +ATOM 1765 N THR B 17 57.627 36.661 37.091 1.00 41.14 N +ATOM 1766 CA THR B 17 58.904 37.293 37.384 1.00 39.75 C +ATOM 1767 C THR B 17 59.111 38.784 37.129 1.00 40.35 C +ATOM 1768 O THR B 17 60.062 39.361 37.663 1.00 45.59 O +ATOM 1769 CB THR B 17 59.994 36.554 36.601 1.00 45.21 C +ATOM 1770 OG1 THR B 17 59.584 36.433 35.226 1.00 44.12 O +ATOM 1771 CG2 THR B 17 60.196 35.146 37.174 1.00 58.69 C +ATOM 1772 N SER B 18 58.278 39.398 36.290 1.00 34.64 N +ATOM 1773 CA SER B 18 58.441 40.816 35.973 1.00 24.33 C +ATOM 1774 C SER B 18 57.835 41.774 36.995 1.00 20.42 C +ATOM 1775 O SER B 18 56.702 41.575 37.449 1.00 15.64 O +ATOM 1776 CB SER B 18 57.882 41.117 34.587 1.00 25.49 C +ATOM 1777 OG SER B 18 58.467 40.271 33.613 1.00 31.75 O +ATOM 1778 N TYR B 19 58.615 42.796 37.354 1.00 13.09 N +ATOM 1779 CA TYR B 19 58.194 43.821 38.292 1.00 12.92 C +ATOM 1780 C TYR B 19 59.242 44.934 38.374 1.00 14.77 C +ATOM 1781 O TYR B 19 60.379 44.773 37.905 1.00 13.46 O +ATOM 1782 CB TYR B 19 57.933 43.224 39.682 1.00 12.04 C +ATOM 1783 CG TYR B 19 59.167 42.763 40.434 1.00 31.16 C +ATOM 1784 CD1 TYR B 19 59.905 43.651 41.236 1.00 32.63 C +ATOM 1785 CD2 TYR B 19 59.584 41.433 40.375 1.00 33.65 C +ATOM 1786 CE1 TYR B 19 61.018 43.221 41.952 1.00 32.00 C +ATOM 1787 CE2 TYR B 19 60.701 40.994 41.091 1.00 35.53 C +ATOM 1788 CZ TYR B 19 61.409 41.893 41.874 1.00 34.21 C +ATOM 1789 OH TYR B 19 62.506 41.468 42.585 1.00 45.65 O +ATOM 1790 N VAL B 20 58.847 46.066 38.947 1.00 13.96 N +ATOM 1791 CA VAL B 20 59.741 47.199 39.125 1.00 12.72 C +ATOM 1792 C VAL B 20 59.638 47.608 40.590 1.00 19.20 C +ATOM 1793 O VAL B 20 58.526 47.815 41.115 1.00 16.61 O +ATOM 1794 CB VAL B 20 59.327 48.403 38.271 1.00 18.59 C +ATOM 1795 CG1 VAL B 20 60.239 49.598 38.567 1.00 19.32 C +ATOM 1796 CG2 VAL B 20 59.385 48.045 36.821 1.00 14.36 C +ATOM 1797 N SER B 21 60.791 47.681 41.252 1.00 22.25 N +ATOM 1798 CA SER B 21 60.853 48.056 42.657 1.00 19.27 C +ATOM 1799 C SER B 21 61.162 49.536 42.771 1.00 15.58 C +ATOM 1800 O SER B 21 62.087 50.048 42.117 1.00 13.37 O +ATOM 1801 CB SER B 21 61.925 47.234 43.371 1.00 29.73 C +ATOM 1802 OG SER B 21 61.974 47.553 44.753 1.00 48.58 O +ATOM 1803 N LEU B 22 60.359 50.220 43.578 1.00 11.54 N +ATOM 1804 CA LEU B 22 60.522 51.647 43.799 1.00 14.47 C +ATOM 1805 C LEU B 22 61.132 51.863 45.174 1.00 22.55 C +ATOM 1806 O LEU B 22 60.660 51.298 46.170 1.00 24.61 O +ATOM 1807 CB LEU B 22 59.169 52.357 43.695 1.00 14.08 C +ATOM 1808 CG LEU B 22 58.784 53.026 42.361 1.00 14.08 C +ATOM 1809 CD1 LEU B 22 59.206 52.201 41.146 1.00 13.55 C +ATOM 1810 CD2 LEU B 22 57.286 53.261 42.360 1.00 8.50 C +ATOM 1811 N LYS B 23 62.195 52.665 45.216 1.00 28.61 N +ATOM 1812 CA LYS B 23 62.887 52.957 46.459 1.00 33.01 C +ATOM 1813 C LYS B 23 62.520 54.333 46.994 1.00 35.96 C +ATOM 1814 O LYS B 23 62.811 55.358 46.375 1.00 32.56 O +ATOM 1815 CB LYS B 23 64.406 52.822 46.278 1.00 54.02 C +ATOM 1816 CG LYS B 23 64.894 51.386 45.994 1.00 57.77 C +ATOM 1817 CD LYS B 23 64.433 50.418 47.075 1.00 64.12 C +ATOM 1818 CE LYS B 23 64.698 48.958 46.704 1.00 76.54 C +ATOM 1819 NZ LYS B 23 66.127 48.524 46.816 1.00 84.49 N +ATOM 1820 N ALA B 24 61.861 54.333 48.147 1.00 46.07 N +ATOM 1821 CA ALA B 24 61.441 55.560 48.800 1.00 55.11 C +ATOM 1822 C ALA B 24 62.294 55.774 50.046 1.00 66.11 C +ATOM 1823 O ALA B 24 62.487 54.852 50.843 1.00 71.52 O +ATOM 1824 CB ALA B 24 59.981 55.460 49.188 1.00 53.88 C +ATOM 1825 N PRO B 25 62.866 56.977 50.201 1.00 73.84 N +ATOM 1826 CA PRO B 25 63.704 57.301 51.364 1.00 78.26 C +ATOM 1827 C PRO B 25 62.836 57.762 52.535 1.00 79.81 C +ATOM 1828 O PRO B 25 62.881 58.923 52.955 1.00 78.98 O +ATOM 1829 CB PRO B 25 64.593 58.419 50.834 1.00 82.83 C +ATOM 1830 CG PRO B 25 63.668 59.145 49.899 1.00 80.40 C +ATOM 1831 CD PRO B 25 62.940 58.036 49.177 1.00 74.28 C +ATOM 1832 N LEU B 26 62.043 56.833 53.053 1.00 81.75 N +ATOM 1833 CA LEU B 26 61.139 57.122 54.153 1.00 83.26 C +ATOM 1834 C LEU B 26 61.801 56.920 55.515 1.00 86.01 C +ATOM 1835 O LEU B 26 62.547 55.952 55.727 1.00 85.06 O +ATOM 1836 CB LEU B 26 59.882 56.259 54.021 1.00 82.80 C +ATOM 1837 CG LEU B 26 58.526 56.958 54.176 1.00 79.03 C +ATOM 1838 CD1 LEU B 26 58.540 58.369 53.572 1.00 73.58 C +ATOM 1839 CD2 LEU B 26 57.459 56.094 53.517 1.00 73.14 C +ATOM 1840 N THR B 27 61.542 57.866 56.417 1.00 88.77 N +ATOM 1841 CA THR B 27 62.091 57.849 57.772 1.00 89.11 C +ATOM 1842 C THR B 27 60.966 57.802 58.812 1.00 83.17 C +ATOM 1843 O THR B 27 61.013 57.016 59.764 1.00 83.26 O +ATOM 1844 CB THR B 27 62.970 59.106 58.040 1.00 93.45 C +ATOM 1845 OG1 THR B 27 62.252 60.291 57.649 1.00 94.77 O +ATOM 1846 CG2 THR B 27 64.295 59.017 57.276 1.00 93.31 C +ATOM 1847 N LYS B 28 59.981 58.678 58.640 1.00 75.99 N +ATOM 1848 CA LYS B 28 58.837 58.754 59.539 1.00 70.49 C +ATOM 1849 C LYS B 28 57.720 57.866 59.010 1.00 60.59 C +ATOM 1850 O LYS B 28 57.570 57.717 57.800 1.00 65.67 O +ATOM 1851 CB LYS B 28 58.317 60.200 59.618 1.00 80.65 C +ATOM 1852 CG LYS B 28 59.116 61.145 60.508 1.00 90.14 C +ATOM 1853 CD LYS B 28 58.821 60.903 61.985 1.00 97.76 C +ATOM 1854 CE LYS B 28 59.567 61.886 62.880 1.00101.49 C +ATOM 1855 NZ LYS B 28 59.220 61.705 64.324 1.00105.26 N +ATOM 1856 N PRO B 29 56.979 57.197 59.906 1.00 49.42 N +ATOM 1857 CA PRO B 29 55.871 56.332 59.481 1.00 45.38 C +ATOM 1858 C PRO B 29 54.698 57.217 59.009 1.00 41.29 C +ATOM 1859 O PRO B 29 54.488 58.325 59.538 1.00 40.94 O +ATOM 1860 CB PRO B 29 55.543 55.539 60.755 1.00 44.12 C +ATOM 1861 CG PRO B 29 55.918 56.475 61.843 1.00 48.89 C +ATOM 1862 CD PRO B 29 57.236 57.036 61.345 1.00 53.62 C +ATOM 1863 N LEU B 30 53.948 56.739 58.014 1.00 31.92 N +ATOM 1864 CA LEU B 30 52.841 57.507 57.451 1.00 21.93 C +ATOM 1865 C LEU B 30 51.558 57.576 58.274 1.00 20.83 C +ATOM 1866 O LEU B 30 51.020 56.549 58.704 1.00 15.23 O +ATOM 1867 CB LEU B 30 52.494 56.995 56.047 1.00 22.54 C +ATOM 1868 CG LEU B 30 53.459 57.158 54.864 1.00 21.36 C +ATOM 1869 CD1 LEU B 30 54.516 58.238 55.146 1.00 16.95 C +ATOM 1870 CD2 LEU B 30 54.105 55.821 54.565 1.00 16.72 C +ATOM 1871 N LYS B 31 51.056 58.801 58.435 1.00 19.29 N +ATOM 1872 CA LYS B 31 49.806 59.082 59.159 1.00 20.56 C +ATOM 1873 C LYS B 31 48.711 59.526 58.171 1.00 20.94 C +ATOM 1874 O LYS B 31 47.557 59.810 58.567 1.00 15.18 O +ATOM 1875 CB LYS B 31 50.031 60.183 60.200 1.00 31.48 C +ATOM 1876 CG LYS B 31 50.705 59.703 61.487 1.00 53.74 C +ATOM 1877 CD LYS B 31 49.771 58.787 62.286 1.00 63.87 C +ATOM 1878 CE LYS B 31 50.437 58.228 63.538 1.00 69.40 C +ATOM 1879 NZ LYS B 31 49.514 57.316 64.283 1.00 76.63 N +ATOM 1880 N ALA B 32 49.114 59.617 56.899 1.00 19.97 N +ATOM 1881 CA ALA B 32 48.271 60.016 55.780 1.00 11.02 C +ATOM 1882 C ALA B 32 49.124 59.869 54.529 1.00 10.41 C +ATOM 1883 O ALA B 32 50.339 59.723 54.626 1.00 14.35 O +ATOM 1884 CB ALA B 32 47.856 61.442 55.938 1.00 9.94 C +ATOM 1885 N PHE B 33 48.498 59.871 53.359 1.00 9.79 N +ATOM 1886 CA PHE B 33 49.243 59.753 52.105 1.00 10.90 C +ATOM 1887 C PHE B 33 48.317 59.942 50.903 1.00 13.95 C +ATOM 1888 O PHE B 33 47.086 59.869 51.041 1.00 14.26 O +ATOM 1889 CB PHE B 33 49.970 58.388 52.013 1.00 9.46 C +ATOM 1890 CG PHE B 33 49.047 57.183 51.960 1.00 11.18 C +ATOM 1891 CD1 PHE B 33 48.568 56.703 50.751 1.00 12.89 C +ATOM 1892 CD2 PHE B 33 48.658 56.530 53.121 1.00 18.21 C +ATOM 1893 CE1 PHE B 33 47.711 55.600 50.697 1.00 8.59 C +ATOM 1894 CE2 PHE B 33 47.805 55.422 53.075 1.00 10.04 C +ATOM 1895 CZ PHE B 33 47.334 54.966 51.860 1.00 13.09 C +ATOM 1896 N THR B 34 48.911 60.237 49.749 1.00 10.68 N +ATOM 1897 CA THR B 34 48.178 60.394 48.501 1.00 10.10 C +ATOM 1898 C THR B 34 49.080 59.762 47.469 1.00 12.03 C +ATOM 1899 O THR B 34 50.282 60.048 47.433 1.00 13.05 O +ATOM 1900 CB THR B 34 48.012 61.851 48.079 1.00 13.02 C +ATOM 1901 OG1 THR B 34 47.354 62.580 49.111 1.00 22.90 O +ATOM 1902 CG2 THR B 34 47.167 61.931 46.823 1.00 18.34 C +ATOM 1903 N VAL B 35 48.534 58.849 46.684 1.00 11.12 N +ATOM 1904 CA VAL B 35 49.322 58.217 45.638 1.00 13.46 C +ATOM 1905 C VAL B 35 48.501 58.301 44.351 1.00 13.74 C +ATOM 1906 O VAL B 35 47.302 57.972 44.342 1.00 14.11 O +ATOM 1907 CB VAL B 35 49.756 56.739 46.008 1.00 12.08 C +ATOM 1908 CG1 VAL B 35 48.863 56.170 47.059 1.00 10.20 C +ATOM 1909 CG2 VAL B 35 49.720 55.831 44.789 1.00 14.88 C +ATOM 1910 N CYS B 36 49.123 58.847 43.313 1.00 9.57 N +ATOM 1911 CA CYS B 36 48.484 59.011 42.018 1.00 10.15 C +ATOM 1912 C CYS B 36 49.312 58.247 40.993 1.00 10.76 C +ATOM 1913 O CYS B 36 50.517 58.087 41.166 1.00 13.15 O +ATOM 1914 CB CYS B 36 48.441 60.504 41.638 1.00 12.36 C +ATOM 1915 SG CYS B 36 47.537 61.600 42.793 1.00 8.50 S +ATOM 1916 N LEU B 37 48.664 57.744 39.949 1.00 11.07 N +ATOM 1917 CA LEU B 37 49.360 57.013 38.900 1.00 10.22 C +ATOM 1918 C LEU B 37 48.474 56.877 37.671 1.00 11.61 C +ATOM 1919 O LEU B 37 47.255 57.126 37.726 1.00 8.50 O +ATOM 1920 CB LEU B 37 49.827 55.631 39.405 1.00 15.40 C +ATOM 1921 CG LEU B 37 48.804 54.604 39.908 1.00 12.81 C +ATOM 1922 CD1 LEU B 37 48.315 53.742 38.775 1.00 8.50 C +ATOM 1923 CD2 LEU B 37 49.459 53.738 40.932 1.00 14.36 C +ATOM 1924 N HIS B 38 49.104 56.503 36.560 1.00 14.08 N +ATOM 1925 CA HIS B 38 48.430 56.322 35.267 1.00 13.87 C +ATOM 1926 C HIS B 38 48.679 54.867 34.859 1.00 13.25 C +ATOM 1927 O HIS B 38 49.814 54.404 34.923 1.00 20.01 O +ATOM 1928 CB HIS B 38 49.113 57.208 34.226 1.00 12.88 C +ATOM 1929 CG HIS B 38 48.224 58.232 33.602 1.00 14.15 C +ATOM 1930 ND1 HIS B 38 48.480 59.583 33.690 1.00 18.83 N +ATOM 1931 CD2 HIS B 38 47.131 58.105 32.814 1.00 14.27 C +ATOM 1932 CE1 HIS B 38 47.585 60.246 32.979 1.00 21.90 C +ATOM 1933 NE2 HIS B 38 46.757 59.372 32.436 1.00 16.72 N +ATOM 1934 N PHE B 39 47.652 54.137 34.469 1.00 8.50 N +ATOM 1935 CA PHE B 39 47.879 52.777 34.035 1.00 8.50 C +ATOM 1936 C PHE B 39 46.990 52.518 32.840 1.00 10.22 C +ATOM 1937 O PHE B 39 46.028 53.247 32.599 1.00 15.77 O +ATOM 1938 CB PHE B 39 47.652 51.754 35.161 1.00 10.11 C +ATOM 1939 CG PHE B 39 46.211 51.545 35.537 1.00 8.58 C +ATOM 1940 CD1 PHE B 39 45.593 52.385 36.465 1.00 15.57 C +ATOM 1941 CD2 PHE B 39 45.480 50.505 34.981 1.00 8.50 C +ATOM 1942 CE1 PHE B 39 44.266 52.184 36.833 1.00 18.10 C +ATOM 1943 CE2 PHE B 39 44.170 50.297 35.333 1.00 8.50 C +ATOM 1944 CZ PHE B 39 43.551 51.133 36.262 1.00 15.43 C +ATOM 1945 N TYR B 40 47.322 51.504 32.064 1.00 10.50 N +ATOM 1946 CA TYR B 40 46.542 51.200 30.877 1.00 9.97 C +ATOM 1947 C TYR B 40 46.669 49.705 30.592 1.00 11.55 C +ATOM 1948 O TYR B 40 47.729 49.233 30.166 1.00 14.59 O +ATOM 1949 CB TYR B 40 47.088 52.042 29.705 1.00 9.57 C +ATOM 1950 CG TYR B 40 46.387 51.804 28.396 1.00 8.50 C +ATOM 1951 CD1 TYR B 40 45.066 51.364 28.373 1.00 11.56 C +ATOM 1952 CD2 TYR B 40 47.030 52.031 27.180 1.00 8.50 C +ATOM 1953 CE1 TYR B 40 44.389 51.158 27.182 1.00 8.50 C +ATOM 1954 CE2 TYR B 40 46.358 51.829 25.972 1.00 15.07 C +ATOM 1955 CZ TYR B 40 45.032 51.394 25.988 1.00 12.04 C +ATOM 1956 OH TYR B 40 44.324 51.226 24.820 1.00 14.46 O +ATOM 1957 N THR B 41 45.593 48.960 30.818 1.00 11.47 N +ATOM 1958 CA THR B 41 45.606 47.506 30.597 1.00 13.03 C +ATOM 1959 C THR B 41 44.312 46.988 29.982 1.00 16.97 C +ATOM 1960 O THR B 41 43.286 47.667 29.983 1.00 19.02 O +ATOM 1961 CB THR B 41 45.863 46.717 31.906 1.00 10.59 C +ATOM 1962 OG1 THR B 41 45.958 45.324 31.604 1.00 9.95 O +ATOM 1963 CG2 THR B 41 44.725 46.923 32.901 1.00 8.50 C +ATOM 1964 N GLU B 42 44.350 45.750 29.518 1.00 19.17 N +ATOM 1965 CA GLU B 42 43.188 45.153 28.878 1.00 26.33 C +ATOM 1966 C GLU B 42 42.637 43.985 29.702 1.00 28.94 C +ATOM 1967 O GLU B 42 41.772 43.238 29.249 1.00 35.08 O +ATOM 1968 CB GLU B 42 43.614 44.654 27.493 1.00 36.20 C +ATOM 1969 CG GLU B 42 42.589 44.844 26.381 1.00 47.71 C +ATOM 1970 CD GLU B 42 43.203 44.703 24.992 1.00 50.57 C +ATOM 1971 OE1 GLU B 42 43.260 43.560 24.478 1.00 58.09 O +ATOM 1972 OE2 GLU B 42 43.637 45.736 24.426 1.00 41.32 O +ATOM 1973 N LEU B 43 43.252 43.739 30.857 1.00 26.44 N +ATOM 1974 CA LEU B 43 42.848 42.631 31.738 1.00 17.37 C +ATOM 1975 C LEU B 43 41.500 42.813 32.402 1.00 17.49 C +ATOM 1976 O LEU B 43 40.831 41.841 32.661 1.00 20.75 O +ATOM 1977 CB LEU B 43 43.877 42.403 32.855 1.00 20.69 C +ATOM 1978 CG LEU B 43 45.148 41.570 32.695 1.00 22.83 C +ATOM 1979 CD1 LEU B 43 45.615 41.559 31.249 1.00 29.77 C +ATOM 1980 CD2 LEU B 43 46.239 42.127 33.618 1.00 16.18 C +ATOM 1981 N SER B 44 41.139 44.052 32.726 1.00 25.11 N +ATOM 1982 CA SER B 44 39.881 44.398 33.406 1.00 25.45 C +ATOM 1983 C SER B 44 38.668 43.482 33.154 1.00 29.55 C +ATOM 1984 O SER B 44 37.878 43.202 34.067 1.00 26.33 O +ATOM 1985 CB SER B 44 39.509 45.843 33.049 1.00 27.14 C +ATOM 1986 OG SER B 44 40.622 46.715 33.190 1.00 26.82 O +ATOM 1987 N SER B 45 38.547 43.006 31.917 1.00 37.12 N +ATOM 1988 CA SER B 45 37.434 42.161 31.493 1.00 44.12 C +ATOM 1989 C SER B 45 37.564 40.656 31.748 1.00 44.89 C +ATOM 1990 O SER B 45 36.581 39.919 31.598 1.00 48.76 O +ATOM 1991 CB SER B 45 37.184 42.379 30.005 1.00 51.60 C +ATOM 1992 OG SER B 45 37.160 43.764 29.695 1.00 64.64 O +ATOM 1993 N THR B 46 38.763 40.186 32.092 1.00 41.32 N +ATOM 1994 CA THR B 46 38.976 38.754 32.341 1.00 31.11 C +ATOM 1995 C THR B 46 39.484 38.374 33.753 1.00 30.64 C +ATOM 1996 O THR B 46 38.944 37.448 34.365 1.00 39.56 O +ATOM 1997 CB THR B 46 39.889 38.123 31.259 1.00 24.96 C +ATOM 1998 OG1 THR B 46 41.268 38.374 31.573 1.00 42.34 O +ATOM 1999 CG2 THR B 46 39.583 38.722 29.891 1.00 22.06 C +ATOM 2000 N ARG B 47 40.506 39.065 34.271 1.00 24.89 N +ATOM 2001 CA ARG B 47 41.032 38.743 35.598 1.00 23.88 C +ATOM 2002 C ARG B 47 41.333 39.974 36.466 1.00 24.15 C +ATOM 2003 O ARG B 47 41.141 41.113 36.026 1.00 24.60 O +ATOM 2004 CB ARG B 47 42.282 37.842 35.480 1.00 20.66 C +ATOM 2005 CG ARG B 47 43.545 38.505 34.952 1.00 13.61 C +ATOM 2006 CD ARG B 47 44.683 37.509 35.006 1.00 17.90 C +ATOM 2007 NE ARG B 47 45.931 38.032 34.451 1.00 28.27 N +ATOM 2008 CZ ARG B 47 46.840 38.719 35.151 1.00 36.54 C +ATOM 2009 NH1 ARG B 47 46.628 38.983 36.441 1.00 35.16 N +ATOM 2010 NH2 ARG B 47 48.006 39.068 34.592 1.00 29.46 N +ATOM 2011 N GLY B 48 41.728 39.729 37.722 1.00 24.07 N +ATOM 2012 CA GLY B 48 42.080 40.813 38.627 1.00 16.81 C +ATOM 2013 C GLY B 48 43.577 41.060 38.478 1.00 14.69 C +ATOM 2014 O GLY B 48 44.274 40.221 37.915 1.00 20.53 O +ATOM 2015 N TYR B 49 44.080 42.187 38.970 1.00 10.08 N +ATOM 2016 CA TYR B 49 45.506 42.498 38.860 1.00 10.35 C +ATOM 2017 C TYR B 49 45.916 43.547 39.863 1.00 15.06 C +ATOM 2018 O TYR B 49 45.083 44.344 40.328 1.00 20.75 O +ATOM 2019 CB TYR B 49 45.862 42.978 37.446 1.00 16.06 C +ATOM 2020 CG TYR B 49 44.950 44.071 36.911 1.00 28.32 C +ATOM 2021 CD1 TYR B 49 45.121 45.408 37.300 1.00 33.15 C +ATOM 2022 CD2 TYR B 49 43.899 43.769 36.034 1.00 24.13 C +ATOM 2023 CE1 TYR B 49 44.261 46.419 36.828 1.00 32.77 C +ATOM 2024 CE2 TYR B 49 43.037 44.772 35.556 1.00 27.51 C +ATOM 2025 CZ TYR B 49 43.221 46.091 35.955 1.00 27.88 C +ATOM 2026 OH TYR B 49 42.369 47.069 35.480 1.00 15.15 O +ATOM 2027 N SER B 50 47.205 43.565 40.182 1.00 16.63 N +ATOM 2028 CA SER B 50 47.744 44.517 41.152 1.00 22.89 C +ATOM 2029 C SER B 50 48.273 45.779 40.473 1.00 26.71 C +ATOM 2030 O SER B 50 49.079 45.713 39.532 1.00 31.77 O +ATOM 2031 CB SER B 50 48.857 43.860 41.975 1.00 18.17 C +ATOM 2032 OG SER B 50 49.448 44.795 42.856 1.00 35.05 O +ATOM 2033 N ILE B 51 47.817 46.926 40.961 1.00 22.97 N +ATOM 2034 CA ILE B 51 48.241 48.199 40.416 1.00 16.86 C +ATOM 2035 C ILE B 51 49.412 48.774 41.221 1.00 18.89 C +ATOM 2036 O ILE B 51 50.477 49.049 40.655 1.00 23.14 O +ATOM 2037 CB ILE B 51 47.066 49.185 40.384 1.00 14.68 C +ATOM 2038 CG1 ILE B 51 45.964 48.633 39.480 1.00 13.92 C +ATOM 2039 CG2 ILE B 51 47.520 50.548 39.876 1.00 10.99 C +ATOM 2040 CD1 ILE B 51 44.695 49.451 39.509 1.00 18.95 C +ATOM 2041 N PHE B 52 49.232 48.894 42.537 1.00 12.83 N +ATOM 2042 CA PHE B 52 50.257 49.442 43.424 1.00 11.01 C +ATOM 2043 C PHE B 52 50.325 48.581 44.703 1.00 17.53 C +ATOM 2044 O PHE B 52 49.312 48.411 45.388 1.00 15.26 O +ATOM 2045 CB PHE B 52 49.882 50.873 43.774 1.00 8.50 C +ATOM 2046 CG PHE B 52 50.940 51.615 44.531 1.00 15.63 C +ATOM 2047 CD1 PHE B 52 52.087 52.074 43.885 1.00 14.52 C +ATOM 2048 CD2 PHE B 52 50.764 51.915 45.888 1.00 18.03 C +ATOM 2049 CE1 PHE B 52 53.045 52.830 44.576 1.00 9.98 C +ATOM 2050 CE2 PHE B 52 51.712 52.668 46.587 1.00 14.71 C +ATOM 2051 CZ PHE B 52 52.855 53.127 45.924 1.00 11.24 C +ATOM 2052 N SER B 53 51.508 48.045 45.023 1.00 21.61 N +ATOM 2053 CA SER B 53 51.696 47.189 46.213 1.00 18.51 C +ATOM 2054 C SER B 53 52.783 47.713 47.171 1.00 13.08 C +ATOM 2055 O SER B 53 53.987 47.630 46.887 1.00 8.93 O +ATOM 2056 CB SER B 53 52.035 45.741 45.787 1.00 19.10 C +ATOM 2057 OG SER B 53 51.981 44.838 46.881 1.00 17.17 O +ATOM 2058 N TYR B 54 52.341 48.236 48.310 1.00 11.89 N +ATOM 2059 CA TYR B 54 53.236 48.784 49.337 1.00 18.15 C +ATOM 2060 C TYR B 54 53.227 47.793 50.495 1.00 25.00 C +ATOM 2061 O TYR B 54 52.227 47.681 51.217 1.00 24.30 O +ATOM 2062 CB TYR B 54 52.700 50.143 49.803 1.00 18.59 C +ATOM 2063 CG TYR B 54 53.566 50.914 50.770 1.00 18.03 C +ATOM 2064 CD1 TYR B 54 53.498 50.673 52.161 1.00 17.56 C +ATOM 2065 CD2 TYR B 54 54.395 51.943 50.312 1.00 16.15 C +ATOM 2066 CE1 TYR B 54 54.231 51.448 53.079 1.00 8.50 C +ATOM 2067 CE2 TYR B 54 55.135 52.718 51.218 1.00 22.70 C +ATOM 2068 CZ TYR B 54 55.040 52.458 52.598 1.00 16.75 C +ATOM 2069 OH TYR B 54 55.756 53.203 53.480 1.00 15.24 O +ATOM 2070 N ALA B 55 54.344 47.089 50.680 1.00 33.38 N +ATOM 2071 CA ALA B 55 54.442 46.067 51.724 1.00 37.05 C +ATOM 2072 C ALA B 55 55.491 46.316 52.807 1.00 36.70 C +ATOM 2073 O ALA B 55 56.539 46.910 52.541 1.00 32.79 O +ATOM 2074 CB ALA B 55 54.678 44.688 51.081 1.00 35.14 C +ATOM 2075 N THR B 56 55.196 45.816 54.010 1.00 37.55 N +ATOM 2076 CA THR B 56 56.073 45.919 55.167 1.00 40.63 C +ATOM 2077 C THR B 56 56.418 44.497 55.592 1.00 45.04 C +ATOM 2078 O THR B 56 55.757 43.538 55.176 1.00 46.19 O +ATOM 2079 CB THR B 56 55.360 46.562 56.385 1.00 46.52 C +ATOM 2080 OG1 THR B 56 54.540 47.658 55.963 1.00 49.10 O +ATOM 2081 CG2 THR B 56 56.395 47.070 57.407 1.00 52.32 C +ATOM 2082 N LYS B 57 57.438 44.365 56.438 1.00 49.51 N +ATOM 2083 CA LYS B 57 57.844 43.055 56.953 1.00 52.04 C +ATOM 2084 C LYS B 57 56.683 42.450 57.750 1.00 51.70 C +ATOM 2085 O LYS B 57 56.349 41.273 57.600 1.00 54.57 O +ATOM 2086 CB LYS B 57 59.071 43.157 57.874 1.00 53.22 C +ATOM 2087 CG LYS B 57 59.499 44.558 58.229 1.00 50.66 C +ATOM 2088 CD LYS B 57 60.496 45.069 57.206 1.00 67.19 C +ATOM 2089 CE LYS B 57 61.803 44.271 57.271 1.00 78.97 C +ATOM 2090 NZ LYS B 57 62.983 44.988 56.675 1.00 81.97 N +ATOM 2091 N ARG B 58 56.051 43.298 58.560 1.00 50.00 N +ATOM 2092 CA ARG B 58 54.929 42.915 59.418 1.00 48.35 C +ATOM 2093 C ARG B 58 53.602 42.715 58.668 1.00 45.54 C +ATOM 2094 O ARG B 58 52.824 41.811 58.984 1.00 43.38 O +ATOM 2095 CB ARG B 58 54.768 43.976 60.525 1.00 55.95 C +ATOM 2096 CG ARG B 58 53.557 43.799 61.456 1.00 72.64 C +ATOM 2097 CD ARG B 58 53.761 44.498 62.819 1.00 77.68 C +ATOM 2098 NE ARG B 58 54.750 43.801 63.640 1.00 74.51 N +ATOM 2099 CZ ARG B 58 54.490 42.737 64.396 1.00 80.08 C +ATOM 2100 NH1 ARG B 58 53.256 42.240 64.467 1.00 75.31 N +ATOM 2101 NH2 ARG B 58 55.490 42.102 65.002 1.00 84.66 N +ATOM 2102 N GLN B 59 53.351 43.563 57.677 1.00 44.25 N +ATOM 2103 CA GLN B 59 52.111 43.515 56.905 1.00 35.53 C +ATOM 2104 C GLN B 59 52.429 43.579 55.410 1.00 30.95 C +ATOM 2105 O GLN B 59 52.903 44.596 54.916 1.00 33.16 O +ATOM 2106 CB GLN B 59 51.206 44.688 57.346 1.00 27.63 C +ATOM 2107 CG GLN B 59 49.974 44.927 56.500 1.00 27.28 C +ATOM 2108 CD GLN B 59 49.044 43.736 56.449 1.00 26.61 C +ATOM 2109 OE1 GLN B 59 49.213 42.819 55.636 1.00 30.94 O +ATOM 2110 NE2 GLN B 59 48.040 43.752 57.299 1.00 23.22 N +ATOM 2111 N ASP B 60 52.156 42.491 54.700 1.00 30.31 N +ATOM 2112 CA ASP B 60 52.432 42.421 53.262 1.00 30.87 C +ATOM 2113 C ASP B 60 51.550 43.347 52.419 1.00 26.63 C +ATOM 2114 O ASP B 60 51.943 43.762 51.327 1.00 28.50 O +ATOM 2115 CB ASP B 60 52.334 40.968 52.758 1.00 38.52 C +ATOM 2116 CG ASP B 60 50.939 40.360 52.959 1.00 46.03 C +ATOM 2117 OD1 ASP B 60 50.389 40.395 54.094 1.00 50.82 O +ATOM 2118 OD2 ASP B 60 50.394 39.833 51.969 1.00 46.38 O +ATOM 2119 N ASN B 61 50.358 43.663 52.916 1.00 19.87 N +ATOM 2120 CA ASN B 61 49.450 44.535 52.184 1.00 12.04 C +ATOM 2121 C ASN B 61 49.196 45.786 52.996 1.00 13.27 C +ATOM 2122 O ASN B 61 48.065 46.030 53.437 1.00 14.18 O +ATOM 2123 CB ASN B 61 48.129 43.816 51.893 1.00 16.02 C +ATOM 2124 CG ASN B 61 48.295 42.654 50.918 1.00 41.29 C +ATOM 2125 OD1 ASN B 61 47.483 41.713 50.916 1.00 43.96 O +ATOM 2126 ND2 ASN B 61 49.354 42.706 50.082 1.00 47.31 N +ATOM 2127 N GLU B 62 50.258 46.564 53.216 1.00 11.37 N +ATOM 2128 CA GLU B 62 50.172 47.802 53.993 1.00 10.44 C +ATOM 2129 C GLU B 62 49.263 48.821 53.292 1.00 15.25 C +ATOM 2130 O GLU B 62 48.455 49.497 53.923 1.00 19.97 O +ATOM 2131 CB GLU B 62 51.566 48.377 54.234 1.00 8.50 C +ATOM 2132 CG GLU B 62 51.617 49.434 55.319 1.00 10.82 C +ATOM 2133 CD GLU B 62 51.284 48.904 56.721 1.00 26.54 C +ATOM 2134 OE1 GLU B 62 50.175 48.336 56.900 1.00 23.65 O +ATOM 2135 OE2 GLU B 62 52.122 49.075 57.650 1.00 26.08 O +ATOM 2136 N ILE B 63 49.462 48.984 51.991 1.00 18.27 N +ATOM 2137 CA ILE B 63 48.638 49.856 51.162 1.00 13.39 C +ATOM 2138 C ILE B 63 48.706 49.179 49.785 1.00 12.08 C +ATOM 2139 O ILE B 63 49.793 48.868 49.275 1.00 8.50 O +ATOM 2140 CB ILE B 63 49.083 51.387 51.171 1.00 12.76 C +ATOM 2141 CG1 ILE B 63 49.118 51.957 49.761 1.00 8.50 C +ATOM 2142 CG2 ILE B 63 50.370 51.634 51.912 1.00 9.53 C +ATOM 2143 CD1 ILE B 63 47.737 52.188 49.216 1.00 21.03 C +ATOM 2144 N LEU B 64 47.538 48.831 49.257 1.00 11.75 N +ATOM 2145 CA LEU B 64 47.450 48.152 47.972 1.00 12.65 C +ATOM 2146 C LEU B 64 46.233 48.581 47.140 1.00 16.49 C +ATOM 2147 O LEU B 64 45.107 48.658 47.645 1.00 16.22 O +ATOM 2148 CB LEU B 64 47.420 46.628 48.199 1.00 21.03 C +ATOM 2149 CG LEU B 64 47.063 45.681 47.038 1.00 15.87 C +ATOM 2150 CD1 LEU B 64 48.246 44.816 46.637 1.00 9.01 C +ATOM 2151 CD2 LEU B 64 45.909 44.816 47.458 1.00 9.45 C +ATOM 2152 N ILE B 65 46.482 48.894 45.869 1.00 15.76 N +ATOM 2153 CA ILE B 65 45.438 49.288 44.923 1.00 11.46 C +ATOM 2154 C ILE B 65 45.324 48.116 43.951 1.00 14.61 C +ATOM 2155 O ILE B 65 46.299 47.739 43.284 1.00 12.11 O +ATOM 2156 CB ILE B 65 45.826 50.541 44.166 1.00 11.68 C +ATOM 2157 CG1 ILE B 65 46.039 51.680 45.160 1.00 10.94 C +ATOM 2158 CG2 ILE B 65 44.748 50.882 43.158 1.00 9.53 C +ATOM 2159 CD1 ILE B 65 46.710 52.897 44.570 1.00 13.45 C +ATOM 2160 N PHE B 66 44.122 47.571 43.839 1.00 14.79 N +ATOM 2161 CA PHE B 66 43.898 46.393 43.018 1.00 13.30 C +ATOM 2162 C PHE B 66 42.588 46.485 42.256 1.00 13.06 C +ATOM 2163 O PHE B 66 41.632 47.105 42.727 1.00 12.85 O +ATOM 2164 CB PHE B 66 43.820 45.207 43.985 1.00 25.12 C +ATOM 2165 CG PHE B 66 43.851 43.855 43.334 1.00 39.24 C +ATOM 2166 CD1 PHE B 66 42.670 43.223 42.951 1.00 43.13 C +ATOM 2167 CD2 PHE B 66 45.062 43.184 43.159 1.00 42.16 C +ATOM 2168 CE1 PHE B 66 42.692 41.940 42.402 1.00 50.12 C +ATOM 2169 CE2 PHE B 66 45.099 41.905 42.616 1.00 41.10 C +ATOM 2170 CZ PHE B 66 43.911 41.281 42.235 1.00 51.89 C +ATOM 2171 N TRP B 67 42.534 45.847 41.091 1.00 10.85 N +ATOM 2172 CA TRP B 67 41.292 45.804 40.318 1.00 20.35 C +ATOM 2173 C TRP B 67 40.744 44.386 40.438 1.00 24.64 C +ATOM 2174 O TRP B 67 41.358 43.443 39.927 1.00 32.68 O +ATOM 2175 CB TRP B 67 41.537 46.098 38.838 1.00 23.98 C +ATOM 2176 CG TRP B 67 40.345 45.742 37.973 1.00 23.90 C +ATOM 2177 CD1 TRP B 67 40.148 44.576 37.277 1.00 17.29 C +ATOM 2178 CD2 TRP B 67 39.191 46.556 37.728 1.00 27.28 C +ATOM 2179 NE1 TRP B 67 38.947 44.616 36.619 1.00 20.42 N +ATOM 2180 CE2 TRP B 67 38.336 45.818 36.872 1.00 28.87 C +ATOM 2181 CE3 TRP B 67 38.799 47.840 38.137 1.00 26.77 C +ATOM 2182 CZ2 TRP B 67 37.104 46.328 36.417 1.00 26.11 C +ATOM 2183 CZ3 TRP B 67 37.574 48.347 37.680 1.00 30.58 C +ATOM 2184 CH2 TRP B 67 36.742 47.588 36.827 1.00 23.69 C +ATOM 2185 N SER B 68 39.626 44.207 41.131 1.00 23.01 N +ATOM 2186 CA SER B 68 39.072 42.864 41.252 1.00 20.71 C +ATOM 2187 C SER B 68 37.965 42.686 40.209 1.00 21.96 C +ATOM 2188 O SER B 68 36.934 43.384 40.210 1.00 14.40 O +ATOM 2189 CB SER B 68 38.599 42.547 42.687 1.00 18.88 C +ATOM 2190 OG SER B 68 37.487 43.339 43.081 1.00 34.80 O +ATOM 2191 N LYS B 69 38.246 41.784 39.279 1.00 22.59 N +ATOM 2192 CA LYS B 69 37.358 41.448 38.178 1.00 26.59 C +ATOM 2193 C LYS B 69 35.875 41.478 38.577 1.00 26.43 C +ATOM 2194 O LYS B 69 35.506 40.996 39.652 1.00 33.62 O +ATOM 2195 CB LYS B 69 37.765 40.057 37.656 1.00 36.80 C +ATOM 2196 CG LYS B 69 37.412 39.728 36.196 1.00 43.16 C +ATOM 2197 CD LYS B 69 35.932 39.389 36.004 1.00 54.22 C +ATOM 2198 CE LYS B 69 35.682 38.550 34.745 1.00 55.33 C +ATOM 2199 NZ LYS B 69 36.116 37.129 34.928 1.00 63.97 N +ATOM 2200 N ASP B 70 35.047 42.090 37.733 1.00 30.18 N +ATOM 2201 CA ASP B 70 33.598 42.169 37.967 1.00 41.36 C +ATOM 2202 C ASP B 70 33.110 43.020 39.146 1.00 43.17 C +ATOM 2203 O ASP B 70 31.901 43.071 39.422 1.00 49.40 O +ATOM 2204 CB ASP B 70 32.987 40.758 38.097 1.00 50.71 C +ATOM 2205 CG ASP B 70 32.794 40.067 36.761 1.00 65.11 C +ATOM 2206 OD1 ASP B 70 32.866 40.742 35.705 1.00 80.41 O +ATOM 2207 OD2 ASP B 70 32.558 38.837 36.774 1.00 72.91 O +ATOM 2208 N ILE B 71 34.022 43.669 39.857 1.00 40.18 N +ATOM 2209 CA ILE B 71 33.607 44.483 40.990 1.00 32.55 C +ATOM 2210 C ILE B 71 34.015 45.942 40.834 1.00 26.35 C +ATOM 2211 O ILE B 71 33.163 46.814 40.738 1.00 26.07 O +ATOM 2212 CB ILE B 71 34.163 43.914 42.320 1.00 38.02 C +ATOM 2213 CG1 ILE B 71 33.630 42.489 42.558 1.00 45.93 C +ATOM 2214 CG2 ILE B 71 33.780 44.831 43.474 1.00 39.89 C +ATOM 2215 CD1 ILE B 71 34.083 41.847 43.879 1.00 52.27 C +ATOM 2216 N GLY B 72 35.322 46.191 40.811 1.00 23.78 N +ATOM 2217 CA GLY B 72 35.838 47.540 40.678 1.00 15.75 C +ATOM 2218 C GLY B 72 37.199 47.694 41.344 1.00 16.22 C +ATOM 2219 O GLY B 72 38.004 46.750 41.414 1.00 12.82 O +ATOM 2220 N TYR B 73 37.471 48.905 41.819 1.00 13.19 N +ATOM 2221 CA TYR B 73 38.729 49.185 42.491 1.00 11.28 C +ATOM 2222 C TYR B 73 38.683 48.732 43.924 1.00 12.61 C +ATOM 2223 O TYR B 73 37.729 49.027 44.646 1.00 16.82 O +ATOM 2224 CB TYR B 73 39.072 50.661 42.420 1.00 8.50 C +ATOM 2225 CG TYR B 73 39.378 51.092 41.015 1.00 13.86 C +ATOM 2226 CD1 TYR B 73 40.594 50.773 40.419 1.00 8.93 C +ATOM 2227 CD2 TYR B 73 38.431 51.770 40.259 1.00 13.06 C +ATOM 2228 CE1 TYR B 73 40.854 51.116 39.106 1.00 8.51 C +ATOM 2229 CE2 TYR B 73 38.681 52.116 38.953 1.00 9.81 C +ATOM 2230 CZ TYR B 73 39.893 51.786 38.381 1.00 14.40 C +ATOM 2231 OH TYR B 73 40.148 52.137 37.075 1.00 31.78 O +ATOM 2232 N SER B 74 39.720 48.011 44.323 1.00 10.90 N +ATOM 2233 CA SER B 74 39.837 47.487 45.669 1.00 11.52 C +ATOM 2234 C SER B 74 40.992 48.199 46.349 1.00 14.22 C +ATOM 2235 O SER B 74 42.166 47.940 46.050 1.00 19.01 O +ATOM 2236 CB SER B 74 40.113 45.991 45.605 1.00 18.20 C +ATOM 2237 OG SER B 74 40.455 45.470 46.877 1.00 29.37 O +ATOM 2238 N PHE B 75 40.665 49.132 47.231 1.00 13.65 N +ATOM 2239 CA PHE B 75 41.689 49.889 47.945 1.00 11.93 C +ATOM 2240 C PHE B 75 41.829 49.316 49.343 1.00 11.96 C +ATOM 2241 O PHE B 75 40.893 49.352 50.139 1.00 10.90 O +ATOM 2242 CB PHE B 75 41.310 51.375 48.022 1.00 15.18 C +ATOM 2243 CG PHE B 75 42.302 52.211 48.763 1.00 8.50 C +ATOM 2244 CD1 PHE B 75 43.582 52.396 48.269 1.00 8.71 C +ATOM 2245 CD2 PHE B 75 41.961 52.795 49.965 1.00 8.50 C +ATOM 2246 CE1 PHE B 75 44.512 53.154 48.965 1.00 12.48 C +ATOM 2247 CE2 PHE B 75 42.891 53.557 50.673 1.00 14.90 C +ATOM 2248 CZ PHE B 75 44.168 53.737 50.172 1.00 10.01 C +ATOM 2249 N THR B 76 43.009 48.806 49.652 1.00 16.88 N +ATOM 2250 CA THR B 76 43.257 48.223 50.965 1.00 15.44 C +ATOM 2251 C THR B 76 44.481 48.833 51.676 1.00 12.76 C +ATOM 2252 O THR B 76 45.567 48.985 51.095 1.00 11.56 O +ATOM 2253 CB THR B 76 43.334 46.640 50.871 1.00 18.85 C +ATOM 2254 OG1 THR B 76 44.370 46.129 51.722 1.00 23.60 O +ATOM 2255 CG2 THR B 76 43.573 46.167 49.433 1.00 19.11 C +ATOM 2256 N VAL B 77 44.274 49.257 52.915 1.00 9.83 N +ATOM 2257 CA VAL B 77 45.360 49.819 53.706 1.00 18.43 C +ATOM 2258 C VAL B 77 45.376 49.122 55.070 1.00 23.23 C +ATOM 2259 O VAL B 77 44.347 49.019 55.732 1.00 26.29 O +ATOM 2260 CB VAL B 77 45.255 51.367 53.856 1.00 19.37 C +ATOM 2261 CG1 VAL B 77 43.804 51.804 53.920 1.00 14.71 C +ATOM 2262 CG2 VAL B 77 46.013 51.849 55.105 1.00 15.76 C +ATOM 2263 N GLY B 78 46.527 48.555 55.426 1.00 23.44 N +ATOM 2264 CA GLY B 78 46.676 47.869 56.690 1.00 18.21 C +ATOM 2265 C GLY B 78 45.940 46.549 56.698 1.00 21.39 C +ATOM 2266 O GLY B 78 45.363 46.157 57.708 1.00 31.68 O +ATOM 2267 N GLY B 79 45.952 45.857 55.568 1.00 19.80 N +ATOM 2268 CA GLY B 79 45.277 44.573 55.488 1.00 20.13 C +ATOM 2269 C GLY B 79 43.759 44.632 55.385 1.00 20.66 C +ATOM 2270 O GLY B 79 43.128 43.605 55.085 1.00 19.02 O +ATOM 2271 N SER B 80 43.168 45.806 55.642 1.00 20.89 N +ATOM 2272 CA SER B 80 41.711 45.983 55.545 1.00 22.48 C +ATOM 2273 C SER B 80 41.315 46.592 54.202 1.00 21.23 C +ATOM 2274 O SER B 80 41.813 47.645 53.801 1.00 28.15 O +ATOM 2275 CB SER B 80 41.176 46.819 56.705 1.00 25.70 C +ATOM 2276 OG SER B 80 41.315 46.125 57.940 1.00 42.82 O +ATOM 2277 N GLU B 81 40.425 45.894 53.509 1.00 18.82 N +ATOM 2278 CA GLU B 81 39.956 46.262 52.173 1.00 15.72 C +ATOM 2279 C GLU B 81 38.687 47.114 52.167 1.00 17.00 C +ATOM 2280 O GLU B 81 37.925 47.133 53.135 1.00 24.00 O +ATOM 2281 CB GLU B 81 39.734 44.961 51.383 1.00 17.11 C +ATOM 2282 CG GLU B 81 39.233 45.100 49.973 1.00 26.90 C +ATOM 2283 CD GLU B 81 38.741 43.786 49.402 1.00 33.12 C +ATOM 2284 OE1 GLU B 81 37.788 43.216 49.982 1.00 42.45 O +ATOM 2285 OE2 GLU B 81 39.294 43.335 48.372 1.00 35.65 O +ATOM 2286 N ILE B 82 38.477 47.818 51.061 1.00 17.72 N +ATOM 2287 CA ILE B 82 37.312 48.671 50.850 1.00 11.26 C +ATOM 2288 C ILE B 82 37.085 48.687 49.332 1.00 10.13 C +ATOM 2289 O ILE B 82 38.028 48.575 48.537 1.00 9.48 O +ATOM 2290 CB ILE B 82 37.550 50.078 51.421 1.00 11.42 C +ATOM 2291 CG1 ILE B 82 36.221 50.719 51.785 1.00 12.81 C +ATOM 2292 CG2 ILE B 82 38.294 50.961 50.421 1.00 16.54 C +ATOM 2293 CD1 ILE B 82 36.391 51.931 52.639 1.00 19.31 C +ATOM 2294 N LEU B 83 35.839 48.810 48.916 1.00 12.03 N +ATOM 2295 CA LEU B 83 35.549 48.756 47.488 1.00 13.85 C +ATOM 2296 C LEU B 83 34.940 49.984 46.837 1.00 14.77 C +ATOM 2297 O LEU B 83 34.085 50.668 47.406 1.00 16.36 O +ATOM 2298 CB LEU B 83 34.659 47.533 47.187 1.00 18.14 C +ATOM 2299 CG LEU B 83 35.299 46.226 46.711 1.00 18.28 C +ATOM 2300 CD1 LEU B 83 36.535 45.861 47.517 1.00 20.05 C +ATOM 2301 CD2 LEU B 83 34.260 45.137 46.814 1.00 25.68 C +ATOM 2302 N PHE B 84 35.371 50.216 45.607 1.00 14.85 N +ATOM 2303 CA PHE B 84 34.883 51.302 44.792 1.00 15.60 C +ATOM 2304 C PHE B 84 34.382 50.640 43.532 1.00 13.50 C +ATOM 2305 O PHE B 84 35.134 50.314 42.610 1.00 15.22 O +ATOM 2306 CB PHE B 84 35.992 52.314 44.529 1.00 16.53 C +ATOM 2307 CG PHE B 84 36.311 53.148 45.727 1.00 14.48 C +ATOM 2308 CD1 PHE B 84 35.334 53.972 46.286 1.00 8.50 C +ATOM 2309 CD2 PHE B 84 37.557 53.058 46.340 1.00 11.04 C +ATOM 2310 CE1 PHE B 84 35.589 54.686 47.429 1.00 8.50 C +ATOM 2311 CE2 PHE B 84 37.825 53.770 47.487 1.00 13.15 C +ATOM 2312 CZ PHE B 84 36.837 54.591 48.039 1.00 15.08 C +ATOM 2313 N GLU B 85 33.100 50.350 43.564 1.00 9.43 N +ATOM 2314 CA GLU B 85 32.446 49.680 42.472 1.00 24.78 C +ATOM 2315 C GLU B 85 32.457 50.437 41.154 1.00 26.02 C +ATOM 2316 O GLU B 85 32.198 51.634 41.099 1.00 33.15 O +ATOM 2317 CB GLU B 85 31.017 49.324 42.882 1.00 38.71 C +ATOM 2318 CG GLU B 85 30.964 48.651 44.258 1.00 63.36 C +ATOM 2319 CD GLU B 85 29.795 47.702 44.403 1.00 78.56 C +ATOM 2320 OE1 GLU B 85 28.695 48.180 44.762 1.00 86.07 O +ATOM 2321 OE2 GLU B 85 29.979 46.481 44.155 1.00 85.78 O +ATOM 2322 N VAL B 86 32.790 49.717 40.096 1.00 30.82 N +ATOM 2323 CA VAL B 86 32.830 50.253 38.738 1.00 38.64 C +ATOM 2324 C VAL B 86 32.138 49.206 37.846 1.00 48.00 C +ATOM 2325 O VAL B 86 32.754 48.211 37.438 1.00 53.58 O +ATOM 2326 CB VAL B 86 34.288 50.479 38.263 1.00 31.92 C +ATOM 2327 CG1 VAL B 86 34.310 50.844 36.780 1.00 34.01 C +ATOM 2328 CG2 VAL B 86 34.944 51.558 39.098 1.00 23.86 C +ATOM 2329 N PRO B 87 30.844 49.419 37.545 1.00 51.17 N +ATOM 2330 CA PRO B 87 30.016 48.531 36.722 1.00 61.61 C +ATOM 2331 C PRO B 87 30.443 48.364 35.255 1.00 73.18 C +ATOM 2332 O PRO B 87 30.758 47.251 34.804 1.00 77.90 O +ATOM 2333 CB PRO B 87 28.633 49.167 36.843 1.00 57.25 C +ATOM 2334 CG PRO B 87 28.954 50.623 36.962 1.00 47.35 C +ATOM 2335 CD PRO B 87 30.089 50.621 37.936 1.00 45.05 C +ATOM 2336 N GLU B 88 30.398 49.464 34.505 1.00 78.54 N +ATOM 2337 CA GLU B 88 30.762 49.464 33.095 1.00 78.12 C +ATOM 2338 C GLU B 88 32.259 49.749 32.983 1.00 71.44 C +ATOM 2339 O GLU B 88 32.713 50.859 33.274 1.00 68.80 O +ATOM 2340 CB GLU B 88 29.951 50.535 32.348 1.00 87.81 C +ATOM 2341 CG GLU B 88 29.987 50.427 30.817 1.00102.63 C +ATOM 2342 CD GLU B 88 29.373 51.641 30.114 1.00110.17 C +ATOM 2343 OE1 GLU B 88 28.316 52.133 30.576 1.00114.70 O +ATOM 2344 OE2 GLU B 88 29.952 52.104 29.098 1.00111.30 O +ATOM 2345 N VAL B 89 33.028 48.728 32.628 1.00 67.49 N +ATOM 2346 CA VAL B 89 34.463 48.899 32.484 1.00 67.58 C +ATOM 2347 C VAL B 89 34.777 49.297 31.050 1.00 63.99 C +ATOM 2348 O VAL B 89 34.212 48.741 30.102 1.00 61.22 O +ATOM 2349 CB VAL B 89 35.254 47.611 32.880 1.00 73.99 C +ATOM 2350 CG1 VAL B 89 35.007 46.465 31.886 1.00 70.79 C +ATOM 2351 CG2 VAL B 89 36.739 47.930 33.000 1.00 75.82 C +ATOM 2352 N THR B 90 35.644 50.293 30.901 1.00 63.79 N +ATOM 2353 CA THR B 90 36.038 50.778 29.584 1.00 62.74 C +ATOM 2354 C THR B 90 37.544 50.628 29.406 1.00 54.31 C +ATOM 2355 O THR B 90 38.309 50.695 30.370 1.00 57.42 O +ATOM 2356 CB THR B 90 35.624 52.258 29.359 1.00 69.22 C +ATOM 2357 OG1 THR B 90 35.811 52.604 27.979 1.00 78.08 O +ATOM 2358 CG2 THR B 90 36.457 53.205 30.239 1.00 70.76 C +ATOM 2359 N VAL B 91 37.954 50.402 28.167 1.00 45.07 N +ATOM 2360 CA VAL B 91 39.358 50.221 27.840 1.00 42.00 C +ATOM 2361 C VAL B 91 39.943 51.534 27.308 1.00 36.89 C +ATOM 2362 O VAL B 91 39.571 52.012 26.234 1.00 42.09 O +ATOM 2363 CB VAL B 91 39.556 49.032 26.825 1.00 44.16 C +ATOM 2364 CG1 VAL B 91 38.715 49.237 25.569 1.00 42.83 C +ATOM 2365 CG2 VAL B 91 41.025 48.862 26.470 1.00 49.33 C +ATOM 2366 N ALA B 92 40.816 52.137 28.105 1.00 25.59 N +ATOM 2367 CA ALA B 92 41.475 53.390 27.767 1.00 11.06 C +ATOM 2368 C ALA B 92 42.419 53.675 28.913 1.00 9.35 C +ATOM 2369 O ALA B 92 42.259 53.116 29.998 1.00 19.00 O +ATOM 2370 CB ALA B 92 40.463 54.483 27.673 1.00 17.38 C +ATOM 2371 N PRO B 93 43.452 54.494 28.692 1.00 8.50 N +ATOM 2372 CA PRO B 93 44.317 54.728 29.845 1.00 8.79 C +ATOM 2373 C PRO B 93 43.463 55.366 30.931 1.00 10.82 C +ATOM 2374 O PRO B 93 42.485 56.070 30.634 1.00 22.46 O +ATOM 2375 CB PRO B 93 45.350 55.703 29.295 1.00 9.31 C +ATOM 2376 CG PRO B 93 45.421 55.352 27.879 1.00 8.50 C +ATOM 2377 CD PRO B 93 43.989 55.161 27.500 1.00 8.50 C +ATOM 2378 N VAL B 94 43.792 55.080 32.180 1.00 8.67 N +ATOM 2379 CA VAL B 94 43.041 55.630 33.296 1.00 13.50 C +ATOM 2380 C VAL B 94 44.009 56.208 34.327 1.00 12.36 C +ATOM 2381 O VAL B 94 45.135 55.722 34.469 1.00 12.14 O +ATOM 2382 CB VAL B 94 42.079 54.558 33.883 1.00 12.81 C +ATOM 2383 CG1 VAL B 94 42.732 53.222 33.857 1.00 16.09 C +ATOM 2384 CG2 VAL B 94 41.634 54.917 35.281 1.00 9.19 C +ATOM 2385 N HIS B 95 43.616 57.316 34.948 1.00 8.50 N +ATOM 2386 CA HIS B 95 44.452 57.977 35.932 1.00 8.50 C +ATOM 2387 C HIS B 95 43.720 57.955 37.257 1.00 10.39 C +ATOM 2388 O HIS B 95 42.561 58.372 37.328 1.00 15.66 O +ATOM 2389 CB HIS B 95 44.724 59.421 35.489 1.00 9.39 C +ATOM 2390 CG HIS B 95 45.340 60.294 36.548 1.00 11.65 C +ATOM 2391 ND1 HIS B 95 46.703 60.427 36.700 1.00 8.50 N +ATOM 2392 CD2 HIS B 95 44.781 61.082 37.503 1.00 8.50 C +ATOM 2393 CE1 HIS B 95 46.958 61.250 37.701 1.00 8.50 C +ATOM 2394 NE2 HIS B 95 45.809 61.659 38.204 1.00 8.50 N +ATOM 2395 N ILE B 96 44.384 57.474 38.306 1.00 9.66 N +ATOM 2396 CA ILE B 96 43.755 57.434 39.622 1.00 9.41 C +ATOM 2397 C ILE B 96 44.622 58.093 40.686 1.00 9.11 C +ATOM 2398 O ILE B 96 45.845 58.120 40.559 1.00 10.49 O +ATOM 2399 CB ILE B 96 43.443 55.982 40.087 1.00 10.62 C +ATOM 2400 CG1 ILE B 96 44.717 55.150 40.117 1.00 15.06 C +ATOM 2401 CG2 ILE B 96 42.426 55.321 39.180 1.00 8.50 C +ATOM 2402 CD1 ILE B 96 44.538 53.844 40.812 1.00 18.85 C +ATOM 2403 N CYS B 97 43.970 58.712 41.665 1.00 8.65 N +ATOM 2404 CA CYS B 97 44.644 59.338 42.801 1.00 8.50 C +ATOM 2405 C CYS B 97 43.813 58.829 43.947 1.00 13.70 C +ATOM 2406 O CYS B 97 42.569 58.860 43.878 1.00 14.10 O +ATOM 2407 CB CYS B 97 44.536 60.859 42.830 1.00 8.50 C +ATOM 2408 SG CYS B 97 45.745 61.784 41.884 1.00 8.50 S +ATOM 2409 N THR B 98 44.479 58.356 44.995 1.00 13.70 N +ATOM 2410 CA THR B 98 43.769 57.852 46.162 1.00 11.29 C +ATOM 2411 C THR B 98 44.499 58.367 47.393 1.00 8.87 C +ATOM 2412 O THR B 98 45.726 58.551 47.351 1.00 8.50 O +ATOM 2413 CB THR B 98 43.686 56.310 46.123 1.00 13.33 C +ATOM 2414 OG1 THR B 98 42.930 55.848 47.241 1.00 25.30 O +ATOM 2415 CG2 THR B 98 45.074 55.681 46.132 1.00 14.77 C +ATOM 2416 N SER B 99 43.740 58.679 48.446 1.00 9.77 N +ATOM 2417 CA SER B 99 44.320 59.211 49.681 1.00 12.70 C +ATOM 2418 C SER B 99 43.652 58.678 50.953 1.00 17.90 C +ATOM 2419 O SER B 99 42.467 58.325 50.949 1.00 24.04 O +ATOM 2420 CB SER B 99 44.314 60.746 49.671 1.00 9.73 C +ATOM 2421 OG SER B 99 43.014 61.290 49.436 1.00 15.73 O +ATOM 2422 N TRP B 100 44.422 58.628 52.040 1.00 19.05 N +ATOM 2423 CA TRP B 100 43.938 58.138 53.326 1.00 14.06 C +ATOM 2424 C TRP B 100 44.497 59.032 54.452 1.00 12.24 C +ATOM 2425 O TRP B 100 45.621 59.545 54.370 1.00 9.97 O +ATOM 2426 CB TRP B 100 44.356 56.657 53.497 1.00 22.34 C +ATOM 2427 CG TRP B 100 44.239 56.103 54.926 1.00 25.32 C +ATOM 2428 CD1 TRP B 100 43.113 55.608 55.529 1.00 18.18 C +ATOM 2429 CD2 TRP B 100 45.286 56.024 55.916 1.00 15.20 C +ATOM 2430 NE1 TRP B 100 43.391 55.238 56.818 1.00 8.50 N +ATOM 2431 CE2 TRP B 100 44.714 55.483 57.081 1.00 9.98 C +ATOM 2432 CE3 TRP B 100 46.651 56.368 55.925 1.00 15.23 C +ATOM 2433 CZ2 TRP B 100 45.455 55.276 58.245 1.00 15.16 C +ATOM 2434 CZ3 TRP B 100 47.389 56.163 57.084 1.00 10.93 C +ATOM 2435 CH2 TRP B 100 46.789 55.623 58.226 1.00 10.29 C +ATOM 2436 N GLU B 101 43.715 59.186 55.510 1.00 13.80 N +ATOM 2437 CA GLU B 101 44.095 60.006 56.655 1.00 15.59 C +ATOM 2438 C GLU B 101 43.820 59.244 57.935 1.00 18.81 C +ATOM 2439 O GLU B 101 42.658 58.932 58.231 1.00 24.27 O +ATOM 2440 CB GLU B 101 43.246 61.277 56.648 1.00 24.27 C +ATOM 2441 CG GLU B 101 43.441 62.201 57.832 1.00 27.22 C +ATOM 2442 CD GLU B 101 42.540 63.420 57.766 1.00 23.01 C +ATOM 2443 OE1 GLU B 101 41.329 63.265 57.999 1.00 16.10 O +ATOM 2444 OE2 GLU B 101 43.048 64.531 57.487 1.00 32.77 O +ATOM 2445 N SER B 102 44.864 58.982 58.715 1.00 18.41 N +ATOM 2446 CA SER B 102 44.694 58.242 59.970 1.00 21.84 C +ATOM 2447 C SER B 102 43.681 58.908 60.910 1.00 22.12 C +ATOM 2448 O SER B 102 42.752 58.251 61.416 1.00 23.22 O +ATOM 2449 CB SER B 102 46.038 58.071 60.695 1.00 21.53 C +ATOM 2450 OG SER B 102 45.846 57.568 62.017 1.00 18.45 O +ATOM 2451 N ALA B 103 43.826 60.221 61.076 1.00 17.40 N +ATOM 2452 CA ALA B 103 42.963 60.997 61.956 1.00 14.49 C +ATOM 2453 C ALA B 103 41.446 60.813 61.828 1.00 16.76 C +ATOM 2454 O ALA B 103 40.733 61.007 62.815 1.00 28.10 O +ATOM 2455 CB ALA B 103 43.309 62.460 61.852 1.00 14.23 C +ATOM 2456 N SER B 104 40.945 60.443 60.650 1.00 10.31 N +ATOM 2457 CA SER B 104 39.499 60.275 60.477 1.00 11.75 C +ATOM 2458 C SER B 104 39.109 58.983 59.774 1.00 12.97 C +ATOM 2459 O SER B 104 37.947 58.543 59.825 1.00 8.50 O +ATOM 2460 CB SER B 104 38.955 61.425 59.660 1.00 15.71 C +ATOM 2461 OG SER B 104 39.483 61.346 58.345 1.00 23.42 O +ATOM 2462 N GLY B 105 40.084 58.410 59.078 1.00 16.46 N +ATOM 2463 CA GLY B 105 39.860 57.180 58.342 1.00 15.72 C +ATOM 2464 C GLY B 105 39.268 57.470 56.984 1.00 15.72 C +ATOM 2465 O GLY B 105 38.955 56.544 56.234 1.00 18.50 O +ATOM 2466 N ILE B 106 39.115 58.752 56.655 1.00 11.58 N +ATOM 2467 CA ILE B 106 38.536 59.100 55.375 1.00 11.00 C +ATOM 2468 C ILE B 106 39.472 58.832 54.213 1.00 12.02 C +ATOM 2469 O ILE B 106 40.590 59.354 54.162 1.00 14.98 O +ATOM 2470 CB ILE B 106 38.080 60.542 55.320 1.00 8.50 C +ATOM 2471 CG1 ILE B 106 36.924 60.761 56.289 1.00 10.87 C +ATOM 2472 CG2 ILE B 106 37.597 60.866 53.929 1.00 13.85 C +ATOM 2473 CD1 ILE B 106 36.388 62.182 56.275 1.00 12.06 C +ATOM 2474 N VAL B 107 39.002 58.009 53.281 1.00 11.01 N +ATOM 2475 CA VAL B 107 39.763 57.670 52.094 1.00 10.01 C +ATOM 2476 C VAL B 107 38.974 58.170 50.888 1.00 9.78 C +ATOM 2477 O VAL B 107 37.754 58.027 50.848 1.00 14.14 O +ATOM 2478 CB VAL B 107 40.060 56.131 52.009 1.00 11.37 C +ATOM 2479 CG1 VAL B 107 38.870 55.314 52.453 1.00 16.91 C +ATOM 2480 CG2 VAL B 107 40.413 55.748 50.613 1.00 16.60 C +ATOM 2481 N GLU B 108 39.657 58.863 49.977 1.00 13.63 N +ATOM 2482 CA GLU B 108 39.057 59.402 48.746 1.00 9.00 C +ATOM 2483 C GLU B 108 39.634 58.595 47.585 1.00 10.55 C +ATOM 2484 O GLU B 108 40.784 58.141 47.636 1.00 8.50 O +ATOM 2485 CB GLU B 108 39.482 60.857 48.514 1.00 8.50 C +ATOM 2486 CG GLU B 108 39.053 61.893 49.541 1.00 18.61 C +ATOM 2487 CD GLU B 108 39.756 63.253 49.345 1.00 27.97 C +ATOM 2488 OE1 GLU B 108 40.651 63.360 48.469 1.00 20.64 O +ATOM 2489 OE2 GLU B 108 39.436 64.214 50.092 1.00 36.57 O +ATOM 2490 N PHE B 109 38.857 58.434 46.529 1.00 11.55 N +ATOM 2491 CA PHE B 109 39.344 57.725 45.360 1.00 10.19 C +ATOM 2492 C PHE B 109 38.891 58.595 44.194 1.00 8.61 C +ATOM 2493 O PHE B 109 37.705 58.883 44.063 1.00 8.68 O +ATOM 2494 CB PHE B 109 38.715 56.316 45.284 1.00 13.52 C +ATOM 2495 CG PHE B 109 39.538 55.313 44.512 1.00 13.63 C +ATOM 2496 CD1 PHE B 109 40.566 54.615 45.138 1.00 13.99 C +ATOM 2497 CD2 PHE B 109 39.309 55.092 43.155 1.00 10.74 C +ATOM 2498 CE1 PHE B 109 41.360 53.716 44.421 1.00 16.59 C +ATOM 2499 CE2 PHE B 109 40.098 54.194 42.432 1.00 9.09 C +ATOM 2500 CZ PHE B 109 41.125 53.507 43.066 1.00 11.62 C +ATOM 2501 N TRP B 110 39.844 59.101 43.426 1.00 8.50 N +ATOM 2502 CA TRP B 110 39.545 59.942 42.275 1.00 9.69 C +ATOM 2503 C TRP B 110 39.913 59.200 41.010 1.00 9.15 C +ATOM 2504 O TRP B 110 41.070 58.842 40.818 1.00 12.23 O +ATOM 2505 CB TRP B 110 40.381 61.216 42.303 1.00 10.83 C +ATOM 2506 CG TRP B 110 40.124 62.080 43.458 1.00 11.80 C +ATOM 2507 CD1 TRP B 110 40.457 61.835 44.742 1.00 11.43 C +ATOM 2508 CD2 TRP B 110 39.471 63.351 43.443 1.00 17.80 C +ATOM 2509 NE1 TRP B 110 40.050 62.873 45.545 1.00 15.16 N +ATOM 2510 CE2 TRP B 110 39.441 63.819 44.771 1.00 16.84 C +ATOM 2511 CE3 TRP B 110 38.910 64.143 42.436 1.00 14.30 C +ATOM 2512 CZ2 TRP B 110 38.870 65.049 45.125 1.00 23.98 C +ATOM 2513 CZ3 TRP B 110 38.343 65.365 42.786 1.00 13.92 C +ATOM 2514 CH2 TRP B 110 38.327 65.806 44.119 1.00 18.09 C +ATOM 2515 N VAL B 111 38.947 58.991 40.135 1.00 8.50 N +ATOM 2516 CA VAL B 111 39.218 58.319 38.879 1.00 8.50 C +ATOM 2517 C VAL B 111 39.036 59.335 37.754 1.00 14.10 C +ATOM 2518 O VAL B 111 37.963 59.939 37.608 1.00 18.63 O +ATOM 2519 CB VAL B 111 38.276 57.131 38.658 1.00 9.84 C +ATOM 2520 CG1 VAL B 111 38.609 56.431 37.356 1.00 8.86 C +ATOM 2521 CG2 VAL B 111 38.398 56.160 39.807 1.00 19.32 C +ATOM 2522 N ASP B 112 40.104 59.555 36.993 1.00 12.50 N +ATOM 2523 CA ASP B 112 40.106 60.499 35.878 1.00 8.69 C +ATOM 2524 C ASP B 112 39.691 61.919 36.257 1.00 10.76 C +ATOM 2525 O ASP B 112 38.956 62.586 35.525 1.00 12.25 O +ATOM 2526 CB ASP B 112 39.257 59.974 34.718 1.00 8.50 C +ATOM 2527 CG ASP B 112 40.000 58.979 33.855 1.00 12.20 C +ATOM 2528 OD1 ASP B 112 41.246 59.091 33.740 1.00 16.09 O +ATOM 2529 OD2 ASP B 112 39.336 58.090 33.276 1.00 8.50 O +ATOM 2530 N GLY B 113 40.174 62.383 37.405 1.00 13.11 N +ATOM 2531 CA GLY B 113 39.871 63.735 37.841 1.00 11.46 C +ATOM 2532 C GLY B 113 38.543 63.933 38.534 1.00 12.60 C +ATOM 2533 O GLY B 113 38.278 65.024 39.049 1.00 16.88 O +ATOM 2534 N LYS B 114 37.696 62.909 38.519 1.00 8.74 N +ATOM 2535 CA LYS B 114 36.394 62.987 39.166 1.00 9.04 C +ATOM 2536 C LYS B 114 36.379 62.103 40.411 1.00 10.14 C +ATOM 2537 O LYS B 114 36.764 60.937 40.369 1.00 12.65 O +ATOM 2538 CB LYS B 114 35.270 62.632 38.186 1.00 25.12 C +ATOM 2539 CG LYS B 114 34.886 63.754 37.163 1.00 31.07 C +ATOM 2540 CD LYS B 114 34.158 64.969 37.801 1.00 40.95 C +ATOM 2541 CE LYS B 114 35.122 66.063 38.322 1.00 40.89 C +ATOM 2542 NZ LYS B 114 34.505 67.006 39.338 1.00 38.08 N +ATOM 2543 N PRO B 115 35.954 62.663 41.549 1.00 9.18 N +ATOM 2544 CA PRO B 115 35.886 61.989 42.839 1.00 8.64 C +ATOM 2545 C PRO B 115 34.737 61.028 43.074 1.00 8.70 C +ATOM 2546 O PRO B 115 33.605 61.266 42.666 1.00 9.89 O +ATOM 2547 CB PRO B 115 35.777 63.151 43.794 1.00 8.50 C +ATOM 2548 CG PRO B 115 34.834 64.021 43.063 1.00 8.50 C +ATOM 2549 CD PRO B 115 35.379 64.011 41.659 1.00 10.65 C +ATOM 2550 N ARG B 116 35.058 59.937 43.749 1.00 8.50 N +ATOM 2551 CA ARG B 116 34.079 58.943 44.141 1.00 12.20 C +ATOM 2552 C ARG B 116 33.743 59.423 45.562 1.00 14.67 C +ATOM 2553 O ARG B 116 34.468 60.259 46.121 1.00 15.19 O +ATOM 2554 CB ARG B 116 34.726 57.557 44.205 1.00 15.69 C +ATOM 2555 CG ARG B 116 35.375 57.108 42.924 1.00 21.77 C +ATOM 2556 CD ARG B 116 34.338 56.701 41.870 1.00 41.08 C +ATOM 2557 NE ARG B 116 33.777 55.375 42.128 1.00 37.59 N +ATOM 2558 CZ ARG B 116 32.606 55.170 42.710 1.00 39.58 C +ATOM 2559 NH1 ARG B 116 31.868 56.203 43.096 1.00 44.71 N +ATOM 2560 NH2 ARG B 116 32.183 53.938 42.914 1.00 36.13 N +ATOM 2561 N VAL B 117 32.688 58.883 46.169 1.00 13.82 N +ATOM 2562 CA VAL B 117 32.315 59.323 47.507 1.00 9.76 C +ATOM 2563 C VAL B 117 33.406 59.006 48.516 1.00 16.90 C +ATOM 2564 O VAL B 117 34.290 58.189 48.244 1.00 21.18 O +ATOM 2565 CB VAL B 117 31.014 58.692 47.982 1.00 8.50 C +ATOM 2566 CG1 VAL B 117 30.388 59.600 49.011 1.00 11.70 C +ATOM 2567 CG2 VAL B 117 30.052 58.469 46.826 1.00 8.84 C +ATOM 2568 N ARG B 118 33.371 59.686 49.661 1.00 17.89 N +ATOM 2569 CA ARG B 118 34.364 59.464 50.711 1.00 11.60 C +ATOM 2570 C ARG B 118 33.942 58.310 51.589 1.00 10.87 C +ATOM 2571 O ARG B 118 32.777 58.214 51.977 1.00 17.55 O +ATOM 2572 CB ARG B 118 34.520 60.701 51.573 1.00 8.50 C +ATOM 2573 CG ARG B 118 34.939 61.933 50.831 1.00 8.50 C +ATOM 2574 CD ARG B 118 35.407 62.974 51.819 1.00 17.46 C +ATOM 2575 NE ARG B 118 35.039 64.329 51.428 1.00 22.49 N +ATOM 2576 CZ ARG B 118 35.903 65.241 51.009 1.00 14.48 C +ATOM 2577 NH1 ARG B 118 37.190 64.946 50.921 1.00 9.09 N +ATOM 2578 NH2 ARG B 118 35.471 66.441 50.680 1.00 8.50 N +ATOM 2579 N LYS B 119 34.895 57.455 51.932 1.00 11.53 N +ATOM 2580 CA LYS B 119 34.612 56.298 52.767 1.00 12.92 C +ATOM 2581 C LYS B 119 35.540 56.271 53.980 1.00 10.82 C +ATOM 2582 O LYS B 119 36.516 57.012 54.018 1.00 13.03 O +ATOM 2583 CB LYS B 119 34.736 55.023 51.913 1.00 14.34 C +ATOM 2584 CG LYS B 119 33.674 54.944 50.835 1.00 10.86 C +ATOM 2585 CD LYS B 119 33.677 53.622 50.103 1.00 16.43 C +ATOM 2586 CE LYS B 119 32.434 53.512 49.215 1.00 23.77 C +ATOM 2587 NZ LYS B 119 32.374 52.240 48.439 1.00 29.03 N +ATOM 2588 N SER B 120 35.212 55.462 54.986 1.00 13.93 N +ATOM 2589 CA SER B 120 36.039 55.365 56.192 1.00 11.34 C +ATOM 2590 C SER B 120 36.797 54.049 56.166 1.00 10.48 C +ATOM 2591 O SER B 120 36.235 53.011 55.786 1.00 11.53 O +ATOM 2592 CB SER B 120 35.160 55.439 57.448 1.00 11.19 C +ATOM 2593 OG SER B 120 35.906 55.786 58.606 1.00 8.50 O +ATOM 2594 N LEU B 121 38.061 54.086 56.577 1.00 8.64 N +ATOM 2595 CA LEU B 121 38.896 52.890 56.599 1.00 9.26 C +ATOM 2596 C LEU B 121 40.162 53.067 57.435 1.00 17.15 C +ATOM 2597 O LEU B 121 40.909 54.032 57.263 1.00 17.37 O +ATOM 2598 CB LEU B 121 39.260 52.475 55.176 1.00 8.50 C +ATOM 2599 CG LEU B 121 40.356 51.435 54.968 1.00 8.50 C +ATOM 2600 CD1 LEU B 121 40.002 50.153 55.642 1.00 11.95 C +ATOM 2601 CD2 LEU B 121 40.524 51.191 53.497 1.00 21.26 C +ATOM 2602 N LYS B 122 40.368 52.137 58.371 1.00 21.76 N +ATOM 2603 CA LYS B 122 41.533 52.114 59.263 1.00 16.30 C +ATOM 2604 C LYS B 122 41.850 53.394 60.034 1.00 17.25 C +ATOM 2605 O LYS B 122 43.006 53.835 60.060 1.00 11.98 O +ATOM 2606 CB LYS B 122 42.778 51.655 58.501 1.00 16.56 C +ATOM 2607 CG LYS B 122 42.889 50.155 58.368 1.00 21.30 C +ATOM 2608 CD LYS B 122 43.203 49.511 59.706 1.00 27.66 C +ATOM 2609 CE LYS B 122 43.347 48.005 59.571 1.00 38.11 C +ATOM 2610 NZ LYS B 122 43.692 47.327 60.858 1.00 46.73 N +ATOM 2611 N LYS B 123 40.842 53.962 60.696 1.00 17.17 N +ATOM 2612 CA LYS B 123 41.059 55.182 61.466 1.00 17.09 C +ATOM 2613 C LYS B 123 42.033 54.895 62.597 1.00 20.74 C +ATOM 2614 O LYS B 123 42.005 53.803 63.181 1.00 27.52 O +ATOM 2615 CB LYS B 123 39.756 55.699 62.062 1.00 15.68 C +ATOM 2616 CG LYS B 123 39.981 56.947 62.890 1.00 15.56 C +ATOM 2617 CD LYS B 123 38.930 57.137 63.973 1.00 19.84 C +ATOM 2618 CE LYS B 123 37.650 57.719 63.430 1.00 15.69 C +ATOM 2619 NZ LYS B 123 36.820 58.216 64.550 1.00 19.05 N +ATOM 2620 N GLY B 124 42.902 55.857 62.892 1.00 19.99 N +ATOM 2621 CA GLY B 124 43.869 55.685 63.961 1.00 19.66 C +ATOM 2622 C GLY B 124 45.059 54.811 63.616 1.00 22.14 C +ATOM 2623 O GLY B 124 46.051 54.806 64.345 1.00 30.42 O +ATOM 2624 N TYR B 125 44.977 54.062 62.522 1.00 18.47 N +ATOM 2625 CA TYR B 125 46.085 53.201 62.114 1.00 21.50 C +ATOM 2626 C TYR B 125 47.289 54.081 61.747 1.00 22.21 C +ATOM 2627 O TYR B 125 47.190 55.310 61.694 1.00 21.05 O +ATOM 2628 CB TYR B 125 45.668 52.331 60.903 1.00 26.43 C +ATOM 2629 CG TYR B 125 46.678 51.273 60.490 1.00 20.75 C +ATOM 2630 CD1 TYR B 125 46.734 50.055 61.147 1.00 31.31 C +ATOM 2631 CD2 TYR B 125 47.569 51.495 59.442 1.00 24.84 C +ATOM 2632 CE1 TYR B 125 47.655 49.071 60.773 1.00 38.76 C +ATOM 2633 CE2 TYR B 125 48.494 50.528 59.054 1.00 31.71 C +ATOM 2634 CZ TYR B 125 48.535 49.312 59.725 1.00 38.67 C +ATOM 2635 OH TYR B 125 49.436 48.324 59.357 1.00 37.86 O +ATOM 2636 N THR B 126 48.426 53.442 61.507 1.00 21.72 N +ATOM 2637 CA THR B 126 49.630 54.159 61.121 1.00 25.86 C +ATOM 2638 C THR B 126 50.468 53.235 60.211 1.00 26.45 C +ATOM 2639 O THR B 126 50.797 52.103 60.583 1.00 27.47 O +ATOM 2640 CB THR B 126 50.399 54.706 62.372 1.00 22.61 C +ATOM 2641 OG1 THR B 126 51.760 54.972 62.019 1.00 24.07 O +ATOM 2642 CG2 THR B 126 50.331 53.737 63.554 1.00 29.11 C +ATOM 2643 N VAL B 127 50.694 53.689 58.978 1.00 23.93 N +ATOM 2644 CA VAL B 127 51.431 52.931 57.977 1.00 18.38 C +ATOM 2645 C VAL B 127 52.939 52.852 58.261 1.00 18.44 C +ATOM 2646 O VAL B 127 53.570 53.840 58.641 1.00 12.18 O +ATOM 2647 CB VAL B 127 51.153 53.509 56.559 1.00 12.94 C +ATOM 2648 CG1 VAL B 127 52.004 52.816 55.498 1.00 17.21 C +ATOM 2649 CG2 VAL B 127 49.679 53.351 56.233 1.00 8.50 C +ATOM 2650 N GLY B 128 53.496 51.655 58.073 1.00 21.46 N +ATOM 2651 CA GLY B 128 54.916 51.424 58.295 1.00 28.03 C +ATOM 2652 C GLY B 128 55.829 52.219 57.374 1.00 30.20 C +ATOM 2653 O GLY B 128 55.543 52.364 56.185 1.00 32.60 O +ATOM 2654 N ALA B 129 56.954 52.675 57.919 1.00 32.37 N +ATOM 2655 CA ALA B 129 57.928 53.483 57.182 1.00 33.35 C +ATOM 2656 C ALA B 129 58.903 52.729 56.274 1.00 40.43 C +ATOM 2657 O ALA B 129 59.294 53.233 55.217 1.00 43.25 O +ATOM 2658 CB ALA B 129 58.699 54.358 58.147 1.00 34.88 C +ATOM 2659 N GLU B 130 59.369 51.563 56.708 1.00 46.08 N +ATOM 2660 CA GLU B 130 60.296 50.791 55.876 1.00 51.34 C +ATOM 2661 C GLU B 130 59.470 49.801 55.071 1.00 46.76 C +ATOM 2662 O GLU B 130 58.898 48.847 55.624 1.00 44.70 O +ATOM 2663 CB GLU B 130 61.349 50.075 56.727 1.00 64.85 C +ATOM 2664 CG GLU B 130 60.795 49.197 57.835 1.00 88.30 C +ATOM 2665 CD GLU B 130 61.895 48.522 58.622 1.00102.92 C +ATOM 2666 OE1 GLU B 130 62.377 49.137 59.601 1.00110.25 O +ATOM 2667 OE2 GLU B 130 62.287 47.387 58.257 1.00109.99 O +ATOM 2668 N ALA B 131 59.401 50.033 53.764 1.00 43.42 N +ATOM 2669 CA ALA B 131 58.577 49.181 52.913 1.00 34.72 C +ATOM 2670 C ALA B 131 59.136 48.874 51.540 1.00 26.87 C +ATOM 2671 O ALA B 131 60.024 49.572 51.029 1.00 29.07 O +ATOM 2672 CB ALA B 131 57.184 49.793 52.764 1.00 38.43 C +ATOM 2673 N SER B 132 58.596 47.802 50.963 1.00 20.63 N +ATOM 2674 CA SER B 132 58.967 47.343 49.637 1.00 24.05 C +ATOM 2675 C SER B 132 57.781 47.763 48.784 1.00 25.15 C +ATOM 2676 O SER B 132 56.654 47.315 49.028 1.00 23.71 O +ATOM 2677 CB SER B 132 59.128 45.808 49.623 1.00 24.89 C +ATOM 2678 OG SER B 132 59.453 45.322 48.322 1.00 31.98 O +ATOM 2679 N ILE B 133 58.030 48.681 47.853 1.00 21.52 N +ATOM 2680 CA ILE B 133 57.000 49.192 46.953 1.00 15.29 C +ATOM 2681 C ILE B 133 57.225 48.589 45.564 1.00 17.30 C +ATOM 2682 O ILE B 133 58.249 48.854 44.910 1.00 21.77 O +ATOM 2683 CB ILE B 133 57.099 50.717 46.867 1.00 18.82 C +ATOM 2684 CG1 ILE B 133 57.040 51.318 48.272 1.00 16.25 C +ATOM 2685 CG2 ILE B 133 55.977 51.269 45.997 1.00 25.85 C +ATOM 2686 CD1 ILE B 133 57.206 52.823 48.305 1.00 16.50 C +ATOM 2687 N ILE B 134 56.271 47.792 45.099 1.00 12.94 N +ATOM 2688 CA ILE B 134 56.429 47.140 43.804 1.00 14.41 C +ATOM 2689 C ILE B 134 55.330 47.424 42.807 1.00 14.05 C +ATOM 2690 O ILE B 134 54.141 47.510 43.148 1.00 14.09 O +ATOM 2691 CB ILE B 134 56.655 45.603 43.977 1.00 23.45 C +ATOM 2692 CG1 ILE B 134 58.090 45.362 44.471 1.00 24.26 C +ATOM 2693 CG2 ILE B 134 56.347 44.841 42.694 1.00 16.90 C +ATOM 2694 CD1 ILE B 134 58.425 43.923 44.714 1.00 37.89 C +ATOM 2695 N LEU B 135 55.758 47.569 41.562 1.00 13.14 N +ATOM 2696 CA LEU B 135 54.859 47.864 40.463 1.00 13.76 C +ATOM 2697 C LEU B 135 54.747 46.640 39.577 1.00 14.69 C +ATOM 2698 O LEU B 135 55.764 46.017 39.265 1.00 15.60 O +ATOM 2699 CB LEU B 135 55.422 49.042 39.651 1.00 8.50 C +ATOM 2700 CG LEU B 135 54.893 50.459 39.873 1.00 8.50 C +ATOM 2701 CD1 LEU B 135 54.591 50.728 41.331 1.00 8.50 C +ATOM 2702 CD2 LEU B 135 55.912 51.449 39.334 1.00 16.15 C +ATOM 2703 N GLY B 136 53.520 46.279 39.208 1.00 16.89 N +ATOM 2704 CA GLY B 136 53.322 45.147 38.313 1.00 24.83 C +ATOM 2705 C GLY B 136 53.115 43.748 38.884 1.00 28.35 C +ATOM 2706 O GLY B 136 52.707 42.836 38.146 1.00 24.02 O +ATOM 2707 N GLN B 137 53.440 43.550 40.162 1.00 27.15 N +ATOM 2708 CA GLN B 137 53.277 42.247 40.812 1.00 16.47 C +ATOM 2709 C GLN B 137 52.564 42.410 42.133 1.00 19.27 C +ATOM 2710 O GLN B 137 52.582 43.486 42.737 1.00 23.92 O +ATOM 2711 CB GLN B 137 54.632 41.573 41.071 1.00 15.11 C +ATOM 2712 CG GLN B 137 55.225 40.859 39.884 1.00 15.69 C +ATOM 2713 CD GLN B 137 54.250 39.887 39.234 1.00 29.83 C +ATOM 2714 OE1 GLN B 137 54.392 39.564 38.051 1.00 27.30 O +ATOM 2715 NE2 GLN B 137 53.258 39.407 40.004 1.00 27.05 N +ATOM 2716 N GLU B 138 51.964 41.330 42.607 1.00 22.05 N +ATOM 2717 CA GLU B 138 51.248 41.381 43.877 1.00 23.33 C +ATOM 2718 C GLU B 138 52.079 40.782 45.001 1.00 23.69 C +ATOM 2719 O GLU B 138 52.315 39.581 45.025 1.00 26.41 O +ATOM 2720 CB GLU B 138 49.918 40.635 43.764 1.00 19.16 C +ATOM 2721 CG GLU B 138 48.844 41.127 44.718 1.00 27.91 C +ATOM 2722 CD GLU B 138 49.127 40.801 46.157 1.00 31.65 C +ATOM 2723 OE1 GLU B 138 48.732 39.699 46.574 1.00 46.91 O +ATOM 2724 OE2 GLU B 138 49.717 41.641 46.873 1.00 40.35 O +ATOM 2725 N GLN B 139 52.522 41.625 45.928 1.00 27.00 N +ATOM 2726 CA GLN B 139 53.324 41.164 47.063 1.00 27.87 C +ATOM 2727 C GLN B 139 52.529 40.434 48.124 1.00 33.69 C +ATOM 2728 O GLN B 139 51.471 40.896 48.575 1.00 30.15 O +ATOM 2729 CB GLN B 139 54.049 42.320 47.735 1.00 24.02 C +ATOM 2730 CG GLN B 139 55.450 42.517 47.268 1.00 26.89 C +ATOM 2731 CD GLN B 139 55.928 43.917 47.565 1.00 39.35 C +ATOM 2732 OE1 GLN B 139 55.725 44.822 46.760 1.00 48.54 O +ATOM 2733 NE2 GLN B 139 56.530 44.115 48.737 1.00 35.64 N +ATOM 2734 N ASP B 140 53.078 39.300 48.539 1.00 39.39 N +ATOM 2735 CA ASP B 140 52.479 38.470 49.579 1.00 46.67 C +ATOM 2736 C ASP B 140 53.515 38.168 50.651 1.00 48.74 C +ATOM 2737 O ASP B 140 53.298 37.354 51.559 1.00 54.10 O +ATOM 2738 CB ASP B 140 51.886 37.190 48.992 1.00 40.61 C +ATOM 2739 CG ASP B 140 50.595 37.454 48.236 1.00 52.64 C +ATOM 2740 OD1 ASP B 140 49.776 38.274 48.716 1.00 55.61 O +ATOM 2741 OD2 ASP B 140 50.398 36.859 47.157 1.00 56.03 O +ATOM 2742 N SER B 141 54.640 38.862 50.526 1.00 47.83 N +ATOM 2743 CA SER B 141 55.762 38.770 51.445 1.00 48.61 C +ATOM 2744 C SER B 141 56.642 39.964 51.079 1.00 43.73 C +ATOM 2745 O SER B 141 56.619 40.441 49.928 1.00 41.91 O +ATOM 2746 CB SER B 141 56.537 37.438 51.266 1.00 57.53 C +ATOM 2747 OG SER B 141 57.488 37.473 50.200 1.00 48.09 O +ATOM 2748 N PHE B 142 57.384 40.472 52.057 1.00 41.59 N +ATOM 2749 CA PHE B 142 58.267 41.614 51.820 1.00 42.59 C +ATOM 2750 C PHE B 142 59.174 41.407 50.586 1.00 42.07 C +ATOM 2751 O PHE B 142 60.165 40.657 50.643 1.00 45.66 O +ATOM 2752 CB PHE B 142 59.128 41.869 53.064 1.00 50.89 C +ATOM 2753 CG PHE B 142 59.828 43.195 53.058 1.00 49.33 C +ATOM 2754 CD1 PHE B 142 59.193 44.324 53.571 1.00 48.65 C +ATOM 2755 CD2 PHE B 142 61.143 43.307 52.593 1.00 53.56 C +ATOM 2756 CE1 PHE B 142 59.859 45.552 53.633 1.00 55.77 C +ATOM 2757 CE2 PHE B 142 61.824 44.531 52.646 1.00 55.25 C +ATOM 2758 CZ PHE B 142 61.182 45.655 53.170 1.00 55.36 C +ATOM 2759 N GLY B 143 58.789 42.042 49.474 1.00 41.27 N +ATOM 2760 CA GLY B 143 59.557 41.964 48.238 1.00 39.06 C +ATOM 2761 C GLY B 143 59.456 40.674 47.434 1.00 42.78 C +ATOM 2762 O GLY B 143 60.273 40.458 46.521 1.00 37.91 O +ATOM 2763 N GLY B 144 58.451 39.842 47.734 1.00 42.37 N +ATOM 2764 CA GLY B 144 58.298 38.589 47.013 1.00 42.86 C +ATOM 2765 C GLY B 144 56.952 37.898 47.120 1.00 46.16 C +ATOM 2766 O GLY B 144 55.950 38.507 47.528 1.00 49.19 O +ATOM 2767 N ASN B 145 56.946 36.612 46.750 1.00 51.12 N +ATOM 2768 CA ASN B 145 55.748 35.761 46.761 1.00 53.96 C +ATOM 2769 C ASN B 145 54.718 36.299 45.765 1.00 49.31 C +ATOM 2770 O ASN B 145 53.571 36.614 46.121 1.00 47.28 O +ATOM 2771 CB ASN B 145 55.154 35.637 48.184 1.00 69.28 C +ATOM 2772 CG ASN B 145 55.882 34.589 49.049 1.00 79.06 C +ATOM 2773 OD1 ASN B 145 57.086 34.704 49.327 1.00 83.36 O +ATOM 2774 ND2 ASN B 145 55.147 33.570 49.481 1.00 78.52 N +ATOM 2775 N PHE B 146 55.144 36.361 44.501 1.00 47.26 N +ATOM 2776 CA PHE B 146 54.312 36.882 43.414 1.00 47.89 C +ATOM 2777 C PHE B 146 53.390 35.862 42.755 1.00 49.38 C +ATOM 2778 O PHE B 146 53.854 34.808 42.283 1.00 48.72 O +ATOM 2779 CB PHE B 146 55.197 37.508 42.326 1.00 35.18 C +ATOM 2780 CG PHE B 146 56.138 38.561 42.842 1.00 26.38 C +ATOM 2781 CD1 PHE B 146 55.743 39.444 43.850 1.00 16.76 C +ATOM 2782 CD2 PHE B 146 57.431 38.653 42.334 1.00 25.11 C +ATOM 2783 CE1 PHE B 146 56.627 40.397 44.341 1.00 21.29 C +ATOM 2784 CE2 PHE B 146 58.324 39.600 42.814 1.00 21.55 C +ATOM 2785 CZ PHE B 146 57.928 40.475 43.819 1.00 24.52 C +ATOM 2786 N GLU B 147 52.083 36.140 42.765 1.00 49.55 N +ATOM 2787 CA GLU B 147 51.199 35.229 42.068 1.00 50.96 C +ATOM 2788 C GLU B 147 50.891 35.846 40.717 1.00 52.87 C +ATOM 2789 O GLU B 147 50.481 37.018 40.604 1.00 52.20 O +ATOM 2790 CB GLU B 147 49.993 34.699 42.856 1.00 52.81 C +ATOM 2791 CG GLU B 147 49.713 33.182 42.556 1.00 52.49 C +ATOM 2792 CD GLU B 147 50.867 32.193 42.936 1.00 55.85 C +ATOM 2793 OE1 GLU B 147 52.083 32.501 42.778 1.00 34.70 O +ATOM 2794 OE2 GLU B 147 50.536 31.059 43.367 1.00 57.17 O +ATOM 2795 N GLY B 148 51.241 35.068 39.688 1.00 56.83 N +ATOM 2796 CA GLY B 148 51.086 35.475 38.293 1.00 49.45 C +ATOM 2797 C GLY B 148 49.675 35.799 37.854 1.00 46.02 C +ATOM 2798 O GLY B 148 49.480 36.463 36.844 1.00 46.34 O +ATOM 2799 N SER B 149 48.698 35.327 38.625 1.00 47.14 N +ATOM 2800 CA SER B 149 47.278 35.555 38.363 1.00 46.42 C +ATOM 2801 C SER B 149 46.892 36.994 38.785 1.00 42.60 C +ATOM 2802 O SER B 149 45.739 37.426 38.629 1.00 45.52 O +ATOM 2803 CB SER B 149 46.458 34.517 39.160 1.00 55.45 C +ATOM 2804 OG SER B 149 45.073 34.572 38.860 1.00 76.53 O +ATOM 2805 N GLN B 150 47.864 37.727 39.321 1.00 31.93 N +ATOM 2806 CA GLN B 150 47.633 39.079 39.777 1.00 24.79 C +ATOM 2807 C GLN B 150 48.691 40.016 39.216 1.00 28.43 C +ATOM 2808 O GLN B 150 48.903 41.114 39.736 1.00 39.13 O +ATOM 2809 CB GLN B 150 47.657 39.094 41.306 1.00 25.80 C +ATOM 2810 CG GLN B 150 46.765 38.034 41.931 1.00 30.75 C +ATOM 2811 CD GLN B 150 46.564 38.223 43.430 1.00 41.13 C +ATOM 2812 OE1 GLN B 150 47.521 38.326 44.201 1.00 36.83 O +ATOM 2813 NE2 GLN B 150 45.305 38.242 43.850 1.00 51.47 N +ATOM 2814 N SER B 151 49.374 39.577 38.167 1.00 28.50 N +ATOM 2815 CA SER B 151 50.413 40.397 37.560 1.00 28.46 C +ATOM 2816 C SER B 151 49.754 41.415 36.642 1.00 27.87 C +ATOM 2817 O SER B 151 48.598 41.241 36.225 1.00 24.99 O +ATOM 2818 CB SER B 151 51.387 39.534 36.759 1.00 35.57 C +ATOM 2819 OG SER B 151 52.437 40.329 36.223 1.00 45.11 O +ATOM 2820 N LEU B 152 50.469 42.498 36.348 1.00 24.99 N +ATOM 2821 CA LEU B 152 49.900 43.503 35.458 1.00 17.49 C +ATOM 2822 C LEU B 152 50.483 43.362 34.064 1.00 14.79 C +ATOM 2823 O LEU B 152 51.709 43.215 33.900 1.00 12.23 O +ATOM 2824 CB LEU B 152 50.176 44.915 35.976 1.00 15.02 C +ATOM 2825 CG LEU B 152 49.814 46.039 35.011 1.00 8.50 C +ATOM 2826 CD1 LEU B 152 48.334 46.292 35.044 1.00 8.50 C +ATOM 2827 CD2 LEU B 152 50.582 47.273 35.386 1.00 15.69 C +ATOM 2828 N VAL B 153 49.604 43.396 33.064 1.00 12.13 N +ATOM 2829 CA VAL B 153 50.039 43.317 31.676 1.00 11.96 C +ATOM 2830 C VAL B 153 49.531 44.580 30.984 1.00 13.34 C +ATOM 2831 O VAL B 153 48.323 44.755 30.800 1.00 9.02 O +ATOM 2832 CB VAL B 153 49.471 42.091 30.959 1.00 15.79 C +ATOM 2833 CG1 VAL B 153 50.199 41.896 29.632 1.00 16.75 C +ATOM 2834 CG2 VAL B 153 49.589 40.854 31.837 1.00 21.93 C +ATOM 2835 N GLY B 154 50.466 45.473 30.668 1.00 12.63 N +ATOM 2836 CA GLY B 154 50.150 46.730 30.031 1.00 8.50 C +ATOM 2837 C GLY B 154 51.172 47.772 30.439 1.00 12.45 C +ATOM 2838 O GLY B 154 52.313 47.439 30.756 1.00 10.76 O +ATOM 2839 N ASP B 155 50.762 49.036 30.453 1.00 13.74 N +ATOM 2840 CA ASP B 155 51.655 50.132 30.817 1.00 11.75 C +ATOM 2841 C ASP B 155 51.251 50.759 32.135 1.00 10.03 C +ATOM 2842 O ASP B 155 50.066 50.802 32.484 1.00 9.73 O +ATOM 2843 CB ASP B 155 51.613 51.237 29.757 1.00 13.19 C +ATOM 2844 CG ASP B 155 52.231 50.825 28.441 1.00 13.90 C +ATOM 2845 OD1 ASP B 155 51.783 49.815 27.858 1.00 17.48 O +ATOM 2846 OD2 ASP B 155 53.143 51.544 27.969 1.00 15.59 O +ATOM 2847 N ILE B 156 52.240 51.275 32.846 1.00 8.50 N +ATOM 2848 CA ILE B 156 51.981 51.962 34.094 1.00 10.89 C +ATOM 2849 C ILE B 156 53.034 53.054 34.182 1.00 12.51 C +ATOM 2850 O ILE B 156 54.193 52.839 33.820 1.00 14.87 O +ATOM 2851 CB ILE B 156 52.063 51.034 35.309 1.00 8.50 C +ATOM 2852 CG1 ILE B 156 51.739 51.814 36.569 1.00 9.29 C +ATOM 2853 CG2 ILE B 156 53.436 50.469 35.441 1.00 10.54 C +ATOM 2854 CD1 ILE B 156 51.675 50.960 37.781 1.00 17.43 C +ATOM 2855 N GLY B 157 52.618 54.238 34.606 1.00 9.64 N +ATOM 2856 CA GLY B 157 53.547 55.335 34.694 1.00 9.43 C +ATOM 2857 C GLY B 157 52.987 56.462 35.531 1.00 14.61 C +ATOM 2858 O GLY B 157 51.890 56.352 36.112 1.00 9.66 O +ATOM 2859 N ASN B 158 53.749 57.556 35.578 1.00 17.55 N +ATOM 2860 CA ASN B 158 53.394 58.744 36.351 1.00 12.13 C +ATOM 2861 C ASN B 158 52.989 58.465 37.784 1.00 12.59 C +ATOM 2862 O ASN B 158 52.011 59.043 38.278 1.00 14.96 O +ATOM 2863 CB ASN B 158 52.301 59.558 35.661 1.00 20.95 C +ATOM 2864 CG ASN B 158 52.856 60.497 34.630 1.00 23.26 C +ATOM 2865 OD1 ASN B 158 52.474 60.456 33.461 1.00 24.89 O +ATOM 2866 ND2 ASN B 158 53.772 61.351 35.053 1.00 28.89 N +ATOM 2867 N VAL B 159 53.737 57.587 38.452 1.00 10.45 N +ATOM 2868 CA VAL B 159 53.433 57.284 39.845 1.00 13.86 C +ATOM 2869 C VAL B 159 54.139 58.318 40.732 1.00 12.32 C +ATOM 2870 O VAL B 159 55.310 58.641 40.513 1.00 10.54 O +ATOM 2871 CB VAL B 159 53.766 55.793 40.252 1.00 8.50 C +ATOM 2872 CG1 VAL B 159 54.503 55.071 39.156 1.00 8.50 C +ATOM 2873 CG2 VAL B 159 54.552 55.736 41.545 1.00 8.82 C +ATOM 2874 N ASN B 160 53.375 58.911 41.647 1.00 12.19 N +ATOM 2875 CA ASN B 160 53.876 59.916 42.583 1.00 14.82 C +ATOM 2876 C ASN B 160 53.179 59.653 43.909 1.00 15.79 C +ATOM 2877 O ASN B 160 52.078 59.085 43.927 1.00 13.83 O +ATOM 2878 CB ASN B 160 53.549 61.332 42.102 1.00 15.35 C +ATOM 2879 CG ASN B 160 54.243 61.674 40.798 1.00 17.68 C +ATOM 2880 OD1 ASN B 160 53.645 61.585 39.727 1.00 29.05 O +ATOM 2881 ND2 ASN B 160 55.504 62.082 40.881 1.00 13.17 N +ATOM 2882 N MET B 161 53.796 60.082 45.009 1.00 13.04 N +ATOM 2883 CA MET B 161 53.229 59.848 46.330 1.00 9.84 C +ATOM 2884 C MET B 161 53.604 60.957 47.282 1.00 10.10 C +ATOM 2885 O MET B 161 54.749 61.401 47.317 1.00 13.17 O +ATOM 2886 CB MET B 161 53.727 58.504 46.872 1.00 17.13 C +ATOM 2887 CG MET B 161 53.145 58.101 48.218 1.00 23.03 C +ATOM 2888 SD MET B 161 53.591 56.416 48.647 1.00 26.20 S +ATOM 2889 CE MET B 161 52.564 56.101 50.058 1.00 8.50 C +ATOM 2890 N TRP B 162 52.623 61.414 48.039 1.00 11.37 N +ATOM 2891 CA TRP B 162 52.823 62.473 49.019 1.00 13.22 C +ATOM 2892 C TRP B 162 52.546 61.874 50.394 1.00 15.51 C +ATOM 2893 O TRP B 162 51.835 60.864 50.501 1.00 16.10 O +ATOM 2894 CB TRP B 162 51.830 63.611 48.781 1.00 14.88 C +ATOM 2895 CG TRP B 162 51.999 64.342 47.480 1.00 21.70 C +ATOM 2896 CD1 TRP B 162 52.531 65.595 47.305 1.00 20.39 C +ATOM 2897 CD2 TRP B 162 51.574 63.904 46.185 1.00 17.40 C +ATOM 2898 NE1 TRP B 162 52.452 65.962 45.984 1.00 10.40 N +ATOM 2899 CE2 TRP B 162 51.869 64.944 45.277 1.00 14.13 C +ATOM 2900 CE3 TRP B 162 50.963 62.737 45.705 1.00 18.13 C +ATOM 2901 CZ2 TRP B 162 51.574 64.849 43.923 1.00 19.83 C +ATOM 2902 CZ3 TRP B 162 50.669 62.645 44.355 1.00 16.88 C +ATOM 2903 CH2 TRP B 162 50.975 63.694 43.481 1.00 19.82 C +ATOM 2904 N ASP B 163 53.096 62.485 51.441 1.00 12.96 N +ATOM 2905 CA ASP B 163 52.860 61.981 52.790 1.00 14.54 C +ATOM 2906 C ASP B 163 51.692 62.686 53.473 1.00 15.31 C +ATOM 2907 O ASP B 163 51.487 62.552 54.689 1.00 19.01 O +ATOM 2908 CB ASP B 163 54.134 62.048 53.654 1.00 21.86 C +ATOM 2909 CG ASP B 163 54.630 63.469 53.900 1.00 24.82 C +ATOM 2910 OD1 ASP B 163 53.835 64.433 53.877 1.00 24.57 O +ATOM 2911 OD2 ASP B 163 55.843 63.613 54.156 1.00 33.15 O +ATOM 2912 N PHE B 164 50.962 63.477 52.694 1.00 10.33 N +ATOM 2913 CA PHE B 164 49.806 64.205 53.200 1.00 11.51 C +ATOM 2914 C PHE B 164 48.675 64.071 52.198 1.00 9.40 C +ATOM 2915 O PHE B 164 48.893 63.557 51.105 1.00 13.08 O +ATOM 2916 CB PHE B 164 50.147 65.682 53.471 1.00 19.08 C +ATOM 2917 CG PHE B 164 50.582 66.451 52.257 1.00 14.67 C +ATOM 2918 CD1 PHE B 164 51.916 66.438 51.853 1.00 18.32 C +ATOM 2919 CD2 PHE B 164 49.660 67.193 51.522 1.00 8.64 C +ATOM 2920 CE1 PHE B 164 52.329 67.152 50.733 1.00 15.21 C +ATOM 2921 CE2 PHE B 164 50.057 67.907 50.407 1.00 12.72 C +ATOM 2922 CZ PHE B 164 51.395 67.888 50.008 1.00 18.66 C +ATOM 2923 N VAL B 165 47.481 64.533 52.564 1.00 9.73 N +ATOM 2924 CA VAL B 165 46.314 64.427 51.687 1.00 10.97 C +ATOM 2925 C VAL B 165 46.119 65.627 50.743 1.00 14.48 C +ATOM 2926 O VAL B 165 45.891 66.759 51.189 1.00 16.57 O +ATOM 2927 CB VAL B 165 45.009 64.197 52.494 1.00 8.50 C +ATOM 2928 CG1 VAL B 165 43.832 63.953 51.562 1.00 13.74 C +ATOM 2929 CG2 VAL B 165 45.172 63.037 53.427 1.00 9.89 C +ATOM 2930 N LEU B 166 46.210 65.365 49.437 1.00 15.55 N +ATOM 2931 CA LEU B 166 46.024 66.389 48.415 1.00 12.01 C +ATOM 2932 C LEU B 166 44.576 66.899 48.441 1.00 11.68 C +ATOM 2933 O LEU B 166 43.614 66.143 48.710 1.00 8.64 O +ATOM 2934 CB LEU B 166 46.344 65.814 47.031 1.00 8.50 C +ATOM 2935 CG LEU B 166 47.691 66.160 46.422 1.00 8.50 C +ATOM 2936 CD1 LEU B 166 48.783 65.882 47.400 1.00 8.50 C +ATOM 2937 CD2 LEU B 166 47.877 65.371 45.155 1.00 9.37 C +ATOM 2938 N SER B 167 44.430 68.191 48.186 1.00 10.06 N +ATOM 2939 CA SER B 167 43.108 68.784 48.169 1.00 15.45 C +ATOM 2940 C SER B 167 42.523 68.579 46.789 1.00 16.17 C +ATOM 2941 O SER B 167 43.243 68.213 45.848 1.00 16.35 O +ATOM 2942 CB SER B 167 43.171 70.285 48.499 1.00 27.04 C +ATOM 2943 OG SER B 167 43.755 71.050 47.453 1.00 35.41 O +ATOM 2944 N PRO B 168 41.208 68.822 46.642 1.00 15.89 N +ATOM 2945 CA PRO B 168 40.542 68.659 45.346 1.00 14.40 C +ATOM 2946 C PRO B 168 41.205 69.507 44.254 1.00 17.41 C +ATOM 2947 O PRO B 168 41.359 69.053 43.122 1.00 25.45 O +ATOM 2948 CB PRO B 168 39.127 69.132 45.642 1.00 20.91 C +ATOM 2949 CG PRO B 168 38.931 68.697 47.049 1.00 19.22 C +ATOM 2950 CD PRO B 168 40.224 69.133 47.695 1.00 18.24 C +ATOM 2951 N ASP B 169 41.637 70.714 44.606 1.00 14.80 N +ATOM 2952 CA ASP B 169 42.274 71.597 43.638 1.00 17.66 C +ATOM 2953 C ASP B 169 43.637 71.064 43.215 1.00 15.47 C +ATOM 2954 O ASP B 169 43.992 71.115 42.037 1.00 20.82 O +ATOM 2955 CB ASP B 169 42.397 73.020 44.203 1.00 26.59 C +ATOM 2956 CG ASP B 169 41.041 73.639 44.544 1.00 32.51 C +ATOM 2957 OD1 ASP B 169 40.238 73.869 43.615 1.00 30.13 O +ATOM 2958 OD2 ASP B 169 40.782 73.894 45.746 1.00 40.27 O +ATOM 2959 N GLU B 170 44.389 70.531 44.169 1.00 11.10 N +ATOM 2960 CA GLU B 170 45.705 69.993 43.870 1.00 8.50 C +ATOM 2961 C GLU B 170 45.509 68.748 43.027 1.00 8.50 C +ATOM 2962 O GLU B 170 46.072 68.636 41.952 1.00 9.49 O +ATOM 2963 CB GLU B 170 46.452 69.671 45.163 1.00 14.81 C +ATOM 2964 CG GLU B 170 46.552 70.853 46.131 1.00 19.97 C +ATOM 2965 CD GLU B 170 47.349 70.548 47.385 1.00 30.28 C +ATOM 2966 OE1 GLU B 170 48.571 70.310 47.273 1.00 44.68 O +ATOM 2967 OE2 GLU B 170 46.762 70.564 48.484 1.00 30.52 O +ATOM 2968 N ILE B 171 44.631 67.856 43.474 1.00 11.13 N +ATOM 2969 CA ILE B 171 44.355 66.616 42.746 1.00 12.50 C +ATOM 2970 C ILE B 171 43.948 66.943 41.331 1.00 13.22 C +ATOM 2971 O ILE B 171 44.232 66.199 40.397 1.00 13.49 O +ATOM 2972 CB ILE B 171 43.251 65.786 43.429 1.00 8.50 C +ATOM 2973 CG1 ILE B 171 43.812 65.210 44.722 1.00 10.32 C +ATOM 2974 CG2 ILE B 171 42.749 64.692 42.513 1.00 8.50 C +ATOM 2975 CD1 ILE B 171 42.857 64.347 45.472 1.00 30.60 C +ATOM 2976 N ASN B 172 43.325 68.094 41.171 1.00 15.37 N +ATOM 2977 CA ASN B 172 42.902 68.504 39.863 1.00 18.15 C +ATOM 2978 C ASN B 172 44.081 68.928 39.016 1.00 12.04 C +ATOM 2979 O ASN B 172 44.209 68.456 37.902 1.00 17.56 O +ATOM 2980 CB ASN B 172 41.877 69.616 39.943 1.00 33.29 C +ATOM 2981 CG ASN B 172 41.308 69.948 38.604 1.00 44.71 C +ATOM 2982 OD1 ASN B 172 41.671 70.962 38.001 1.00 53.44 O +ATOM 2983 ND2 ASN B 172 40.442 69.074 38.097 1.00 43.29 N +ATOM 2984 N THR B 173 44.963 69.778 39.532 1.00 8.70 N +ATOM 2985 CA THR B 173 46.108 70.193 38.727 1.00 12.11 C +ATOM 2986 C THR B 173 46.972 68.972 38.388 1.00 13.11 C +ATOM 2987 O THR B 173 47.449 68.858 37.253 1.00 19.14 O +ATOM 2988 CB THR B 173 46.990 71.335 39.347 1.00 8.50 C +ATOM 2989 OG1 THR B 173 48.049 70.767 40.113 1.00 8.50 O +ATOM 2990 CG2 THR B 173 46.159 72.291 40.203 1.00 8.50 C +ATOM 2991 N ILE B 174 47.146 68.041 39.324 1.00 8.50 N +ATOM 2992 CA ILE B 174 47.935 66.853 39.018 1.00 8.50 C +ATOM 2993 C ILE B 174 47.352 66.199 37.774 1.00 8.50 C +ATOM 2994 O ILE B 174 48.073 65.874 36.825 1.00 8.50 O +ATOM 2995 CB ILE B 174 47.929 65.820 40.160 1.00 8.50 C +ATOM 2996 CG1 ILE B 174 48.966 66.195 41.215 1.00 17.93 C +ATOM 2997 CG2 ILE B 174 48.322 64.451 39.646 1.00 12.37 C +ATOM 2998 CD1 ILE B 174 48.549 67.313 42.137 1.00 25.38 C +ATOM 2999 N TYR B 175 46.032 66.062 37.755 1.00 10.53 N +ATOM 3000 CA TYR B 175 45.350 65.441 36.616 1.00 13.42 C +ATOM 3001 C TYR B 175 45.542 66.201 35.317 1.00 18.69 C +ATOM 3002 O TYR B 175 45.906 65.625 34.292 1.00 24.44 O +ATOM 3003 CB TYR B 175 43.849 65.289 36.882 1.00 12.82 C +ATOM 3004 CG TYR B 175 43.077 64.732 35.711 1.00 10.03 C +ATOM 3005 CD1 TYR B 175 43.479 63.556 35.081 1.00 12.83 C +ATOM 3006 CD2 TYR B 175 41.948 65.388 35.229 1.00 17.79 C +ATOM 3007 CE1 TYR B 175 42.777 63.047 33.994 1.00 26.51 C +ATOM 3008 CE2 TYR B 175 41.231 64.890 34.148 1.00 24.83 C +ATOM 3009 CZ TYR B 175 41.653 63.718 33.531 1.00 33.14 C +ATOM 3010 OH TYR B 175 40.961 63.207 32.453 1.00 46.14 O +ATOM 3011 N LEU B 176 45.271 67.497 35.376 1.00 20.92 N +ATOM 3012 CA LEU B 176 45.376 68.385 34.228 1.00 21.54 C +ATOM 3013 C LEU B 176 46.780 68.667 33.743 1.00 23.90 C +ATOM 3014 O LEU B 176 46.954 69.312 32.709 1.00 27.27 O +ATOM 3015 CB LEU B 176 44.677 69.706 34.531 1.00 20.63 C +ATOM 3016 CG LEU B 176 43.313 69.913 33.871 1.00 22.69 C +ATOM 3017 CD1 LEU B 176 42.672 68.583 33.420 1.00 23.04 C +ATOM 3018 CD2 LEU B 176 42.431 70.660 34.852 1.00 27.12 C +ATOM 3019 N GLY B 177 47.775 68.203 34.486 1.00 25.91 N +ATOM 3020 CA GLY B 177 49.147 68.434 34.087 1.00 33.82 C +ATOM 3021 C GLY B 177 49.651 69.793 34.533 1.00 38.05 C +ATOM 3022 O GLY B 177 50.044 70.633 33.715 1.00 46.54 O +ATOM 3023 N GLY B 178 49.570 70.041 35.833 1.00 38.95 N +ATOM 3024 CA GLY B 178 50.056 71.292 36.368 1.00 37.71 C +ATOM 3025 C GLY B 178 51.373 70.979 37.043 1.00 39.57 C +ATOM 3026 O GLY B 178 51.868 69.843 36.933 1.00 41.25 O +ATOM 3027 N PRO B 179 52.013 71.974 37.671 1.00 35.36 N +ATOM 3028 CA PRO B 179 53.287 71.731 38.350 1.00 36.30 C +ATOM 3029 C PRO B 179 53.037 71.428 39.834 1.00 33.71 C +ATOM 3030 O PRO B 179 52.179 72.051 40.468 1.00 33.74 O +ATOM 3031 CB PRO B 179 54.023 73.046 38.148 1.00 46.35 C +ATOM 3032 CG PRO B 179 52.905 74.050 38.260 1.00 39.22 C +ATOM 3033 CD PRO B 179 51.758 73.416 37.510 1.00 31.33 C +ATOM 3034 N PHE B 180 53.782 70.465 40.372 1.00 31.39 N +ATOM 3035 CA PHE B 180 53.641 70.056 41.767 1.00 29.16 C +ATOM 3036 C PHE B 180 54.922 69.359 42.211 1.00 30.71 C +ATOM 3037 O PHE B 180 55.766 68.995 41.364 1.00 30.80 O +ATOM 3038 CB PHE B 180 52.460 69.089 41.916 1.00 31.41 C +ATOM 3039 CG PHE B 180 52.492 67.941 40.940 1.00 31.49 C +ATOM 3040 CD1 PHE B 180 51.917 68.069 39.673 1.00 38.61 C +ATOM 3041 CD2 PHE B 180 53.132 66.753 41.263 1.00 32.07 C +ATOM 3042 CE1 PHE B 180 51.983 67.038 38.744 1.00 34.73 C +ATOM 3043 CE2 PHE B 180 53.207 65.707 40.340 1.00 38.50 C +ATOM 3044 CZ PHE B 180 52.631 65.852 39.078 1.00 42.65 C +ATOM 3045 N SER B 181 55.054 69.154 43.524 1.00 28.60 N +ATOM 3046 CA SER B 181 56.233 68.498 44.085 1.00 31.94 C +ATOM 3047 C SER B 181 55.894 67.417 45.110 1.00 29.17 C +ATOM 3048 O SER B 181 55.513 67.721 46.242 1.00 37.45 O +ATOM 3049 CB SER B 181 57.198 69.527 44.706 1.00 37.14 C +ATOM 3050 OG SER B 181 58.410 69.621 43.961 1.00 54.42 O +ATOM 3051 N PRO B 182 55.983 66.137 44.706 1.00 23.06 N +ATOM 3052 CA PRO B 182 55.694 65.007 45.591 1.00 22.82 C +ATOM 3053 C PRO B 182 56.794 64.999 46.647 1.00 25.67 C +ATOM 3054 O PRO B 182 57.851 65.612 46.437 1.00 29.12 O +ATOM 3055 CB PRO B 182 55.855 63.799 44.666 1.00 22.95 C +ATOM 3056 CG PRO B 182 55.625 64.354 43.312 1.00 21.73 C +ATOM 3057 CD PRO B 182 56.350 65.654 43.364 1.00 17.66 C +ATOM 3058 N ASN B 183 56.578 64.302 47.762 1.00 24.27 N +ATOM 3059 CA ASN B 183 57.610 64.267 48.801 1.00 18.04 C +ATOM 3060 C ASN B 183 57.891 62.891 49.367 1.00 16.50 C +ATOM 3061 O ASN B 183 58.360 62.764 50.489 1.00 24.97 O +ATOM 3062 CB ASN B 183 57.312 65.274 49.925 1.00 15.80 C +ATOM 3063 CG ASN B 183 56.102 64.891 50.769 1.00 22.75 C +ATOM 3064 OD1 ASN B 183 55.321 63.979 50.433 1.00 23.76 O +ATOM 3065 ND2 ASN B 183 55.933 65.601 51.874 1.00 21.55 N +ATOM 3066 N VAL B 184 57.563 61.864 48.593 1.00 15.54 N +ATOM 3067 CA VAL B 184 57.809 60.470 48.979 1.00 14.83 C +ATOM 3068 C VAL B 184 58.305 59.780 47.712 1.00 14.94 C +ATOM 3069 O VAL B 184 59.466 59.385 47.634 1.00 17.94 O +ATOM 3070 CB VAL B 184 56.529 59.750 49.504 1.00 16.06 C +ATOM 3071 CG1 VAL B 184 56.837 58.287 49.823 1.00 9.38 C +ATOM 3072 CG2 VAL B 184 56.005 60.451 50.739 1.00 20.34 C +ATOM 3073 N LEU B 185 57.427 59.676 46.713 1.00 14.06 N +ATOM 3074 CA LEU B 185 57.773 59.073 45.427 1.00 12.20 C +ATOM 3075 C LEU B 185 57.632 60.192 44.412 1.00 14.87 C +ATOM 3076 O LEU B 185 56.616 60.884 44.390 1.00 17.02 O +ATOM 3077 CB LEU B 185 56.819 57.926 45.089 1.00 16.38 C +ATOM 3078 CG LEU B 185 57.417 56.505 45.102 1.00 24.48 C +ATOM 3079 CD1 LEU B 185 58.206 56.266 46.374 1.00 21.32 C +ATOM 3080 CD2 LEU B 185 56.316 55.454 44.972 1.00 21.16 C +ATOM 3081 N ASN B 186 58.669 60.403 43.612 1.00 17.70 N +ATOM 3082 CA ASN B 186 58.672 61.467 42.614 1.00 14.13 C +ATOM 3083 C ASN B 186 59.042 60.901 41.242 1.00 17.38 C +ATOM 3084 O ASN B 186 60.177 60.466 41.037 1.00 22.20 O +ATOM 3085 CB ASN B 186 59.690 62.534 43.025 1.00 16.31 C +ATOM 3086 CG ASN B 186 59.647 63.755 42.133 1.00 23.71 C +ATOM 3087 OD1 ASN B 186 59.275 63.672 40.957 1.00 26.85 O +ATOM 3088 ND2 ASN B 186 60.010 64.903 42.690 1.00 24.87 N +ATOM 3089 N TRP B 187 58.101 60.935 40.302 1.00 13.78 N +ATOM 3090 CA TRP B 187 58.335 60.402 38.971 1.00 11.02 C +ATOM 3091 C TRP B 187 59.438 61.143 38.230 1.00 13.39 C +ATOM 3092 O TRP B 187 60.006 60.620 37.260 1.00 19.40 O +ATOM 3093 CB TRP B 187 57.041 60.422 38.166 1.00 11.57 C +ATOM 3094 CG TRP B 187 57.065 59.548 36.934 1.00 15.70 C +ATOM 3095 CD1 TRP B 187 57.025 59.965 35.635 1.00 18.20 C +ATOM 3096 CD2 TRP B 187 57.095 58.114 36.890 1.00 15.78 C +ATOM 3097 NE1 TRP B 187 57.025 58.884 34.787 1.00 19.83 N +ATOM 3098 CE2 TRP B 187 57.065 57.737 35.529 1.00 15.33 C +ATOM 3099 CE3 TRP B 187 57.142 57.114 37.867 1.00 16.46 C +ATOM 3100 CZ2 TRP B 187 57.079 56.405 35.120 1.00 14.39 C +ATOM 3101 CZ3 TRP B 187 57.158 55.779 37.454 1.00 16.29 C +ATOM 3102 CH2 TRP B 187 57.127 55.442 36.095 1.00 10.21 C +ATOM 3103 N ARG B 188 59.749 62.355 38.674 1.00 9.41 N +ATOM 3104 CA ARG B 188 60.796 63.113 38.014 1.00 22.43 C +ATOM 3105 C ARG B 188 62.196 62.834 38.580 1.00 26.84 C +ATOM 3106 O ARG B 188 63.221 63.135 37.953 1.00 29.75 O +ATOM 3107 CB ARG B 188 60.396 64.579 37.886 1.00 41.06 C +ATOM 3108 CG ARG B 188 59.054 64.683 37.136 1.00 54.00 C +ATOM 3109 CD ARG B 188 58.904 65.954 36.322 1.00 75.38 C +ATOM 3110 NE ARG B 188 58.619 67.127 37.150 1.00 90.24 N +ATOM 3111 CZ ARG B 188 59.060 68.355 36.885 1.00 89.77 C +ATOM 3112 NH1 ARG B 188 59.813 68.570 35.809 1.00 87.25 N +ATOM 3113 NH2 ARG B 188 58.736 69.371 37.685 1.00 89.60 N +ATOM 3114 N ALA B 189 62.222 62.182 39.738 1.00 25.55 N +ATOM 3115 CA ALA B 189 63.469 61.800 40.391 1.00 22.33 C +ATOM 3116 C ALA B 189 63.208 60.413 40.976 1.00 22.99 C +ATOM 3117 O ALA B 189 63.313 60.199 42.187 1.00 27.47 O +ATOM 3118 CB ALA B 189 63.805 62.788 41.496 1.00 19.92 C +ATOM 3119 N LEU B 190 62.819 59.483 40.112 1.00 20.17 N +ATOM 3120 CA LEU B 190 62.500 58.129 40.537 1.00 21.63 C +ATOM 3121 C LEU B 190 63.775 57.307 40.715 1.00 27.56 C +ATOM 3122 O LEU B 190 64.756 57.465 39.955 1.00 28.10 O +ATOM 3123 CB LEU B 190 61.569 57.449 39.518 1.00 15.52 C +ATOM 3124 CG LEU B 190 60.815 56.206 40.006 1.00 13.90 C +ATOM 3125 CD1 LEU B 190 59.627 56.658 40.817 1.00 13.85 C +ATOM 3126 CD2 LEU B 190 60.355 55.358 38.850 1.00 8.50 C +ATOM 3127 N LYS B 191 63.783 56.478 41.760 1.00 31.94 N +ATOM 3128 CA LYS B 191 64.915 55.603 42.060 1.00 30.99 C +ATOM 3129 C LYS B 191 64.281 54.224 42.061 1.00 25.14 C +ATOM 3130 O LYS B 191 63.555 53.860 42.990 1.00 20.37 O +ATOM 3131 CB LYS B 191 65.509 55.959 43.438 1.00 45.15 C +ATOM 3132 CG LYS B 191 66.989 55.614 43.592 1.00 65.49 C +ATOM 3133 CD LYS B 191 67.638 56.410 44.725 1.00 77.35 C +ATOM 3134 CE LYS B 191 69.141 56.128 44.826 1.00 90.02 C +ATOM 3135 NZ LYS B 191 69.827 57.018 45.812 1.00 92.36 N +ATOM 3136 N TYR B 192 64.509 53.481 40.990 1.00 24.43 N +ATOM 3137 CA TYR B 192 63.890 52.170 40.867 1.00 28.68 C +ATOM 3138 C TYR B 192 64.867 51.087 40.455 1.00 33.44 C +ATOM 3139 O TYR B 192 66.041 51.364 40.180 1.00 39.97 O +ATOM 3140 CB TYR B 192 62.763 52.241 39.833 1.00 27.98 C +ATOM 3141 CG TYR B 192 63.255 52.614 38.454 1.00 19.03 C +ATOM 3142 CD1 TYR B 192 63.658 53.919 38.165 1.00 14.74 C +ATOM 3143 CD2 TYR B 192 63.367 51.650 37.456 1.00 13.46 C +ATOM 3144 CE1 TYR B 192 64.167 54.251 36.912 1.00 20.88 C +ATOM 3145 CE2 TYR B 192 63.876 51.968 36.200 1.00 16.30 C +ATOM 3146 CZ TYR B 192 64.276 53.271 35.931 1.00 24.01 C +ATOM 3147 OH TYR B 192 64.788 53.594 34.683 1.00 34.18 O +ATOM 3148 N GLU B 193 64.342 49.868 40.350 1.00 35.13 N +ATOM 3149 CA GLU B 193 65.118 48.695 39.959 1.00 38.17 C +ATOM 3150 C GLU B 193 64.158 47.787 39.190 1.00 36.35 C +ATOM 3151 O GLU B 193 63.092 47.412 39.684 1.00 36.60 O +ATOM 3152 CB GLU B 193 65.652 47.987 41.213 1.00 54.17 C +ATOM 3153 CG GLU B 193 66.787 46.999 40.981 1.00 67.96 C +ATOM 3154 CD GLU B 193 67.270 46.389 42.281 1.00 79.64 C +ATOM 3155 OE1 GLU B 193 66.655 45.394 42.729 1.00 83.60 O +ATOM 3156 OE2 GLU B 193 68.247 46.919 42.862 1.00 88.15 O +ATOM 3157 N VAL B 194 64.514 47.491 37.951 1.00 35.06 N +ATOM 3158 CA VAL B 194 63.690 46.658 37.086 1.00 33.09 C +ATOM 3159 C VAL B 194 64.088 45.202 37.228 1.00 34.59 C +ATOM 3160 O VAL B 194 65.256 44.896 37.472 1.00 41.51 O +ATOM 3161 CB VAL B 194 63.863 47.100 35.610 1.00 34.82 C +ATOM 3162 CG1 VAL B 194 63.159 46.150 34.658 1.00 38.90 C +ATOM 3163 CG2 VAL B 194 63.300 48.498 35.431 1.00 44.81 C +ATOM 3164 N GLN B 195 63.125 44.305 37.062 1.00 33.62 N +ATOM 3165 CA GLN B 195 63.396 42.880 37.162 1.00 33.08 C +ATOM 3166 C GLN B 195 62.487 42.125 36.211 1.00 28.49 C +ATOM 3167 O GLN B 195 61.260 42.247 36.284 1.00 29.76 O +ATOM 3168 CB GLN B 195 63.136 42.398 38.593 1.00 45.87 C +ATOM 3169 CG GLN B 195 63.998 41.231 39.030 1.00 60.71 C +ATOM 3170 CD GLN B 195 65.464 41.609 39.139 1.00 70.87 C +ATOM 3171 OE1 GLN B 195 66.303 41.087 38.410 1.00 80.91 O +ATOM 3172 NE2 GLN B 195 65.777 42.525 40.047 1.00 69.61 N +ATOM 3173 N GLY B 196 63.084 41.385 35.286 1.00 23.02 N +ATOM 3174 CA GLY B 196 62.276 40.611 34.366 1.00 25.34 C +ATOM 3175 C GLY B 196 61.991 41.266 33.033 1.00 30.05 C +ATOM 3176 O GLY B 196 62.755 42.112 32.556 1.00 36.41 O +ATOM 3177 N GLU B 197 60.871 40.874 32.438 1.00 27.34 N +ATOM 3178 CA GLU B 197 60.454 41.375 31.133 1.00 21.59 C +ATOM 3179 C GLU B 197 59.699 42.702 31.204 1.00 22.51 C +ATOM 3180 O GLU B 197 58.477 42.749 30.976 1.00 29.30 O +ATOM 3181 CB GLU B 197 59.571 40.324 30.464 1.00 25.30 C +ATOM 3182 CG GLU B 197 59.333 40.528 28.984 1.00 31.03 C +ATOM 3183 CD GLU B 197 60.394 39.857 28.113 1.00 43.40 C +ATOM 3184 OE1 GLU B 197 61.535 39.613 28.592 1.00 42.17 O +ATOM 3185 OE2 GLU B 197 60.070 39.571 26.937 1.00 42.91 O +ATOM 3186 N VAL B 198 60.407 43.769 31.554 1.00 15.73 N +ATOM 3187 CA VAL B 198 59.789 45.089 31.627 1.00 15.27 C +ATOM 3188 C VAL B 198 60.690 46.093 30.916 1.00 16.70 C +ATOM 3189 O VAL B 198 61.909 46.093 31.108 1.00 17.52 O +ATOM 3190 CB VAL B 198 59.444 45.525 33.101 1.00 14.08 C +ATOM 3191 CG1 VAL B 198 60.092 44.601 34.109 1.00 8.50 C +ATOM 3192 CG2 VAL B 198 59.831 46.974 33.356 1.00 8.50 C +ATOM 3193 N PHE B 199 60.080 46.898 30.048 1.00 14.52 N +ATOM 3194 CA PHE B 199 60.809 47.896 29.271 1.00 15.47 C +ATOM 3195 C PHE B 199 60.318 49.311 29.571 1.00 17.90 C +ATOM 3196 O PHE B 199 59.212 49.505 30.096 1.00 22.14 O +ATOM 3197 CB PHE B 199 60.625 47.637 27.772 1.00 19.63 C +ATOM 3198 CG PHE B 199 60.823 46.201 27.367 1.00 25.40 C +ATOM 3199 CD1 PHE B 199 59.777 45.285 27.459 1.00 18.31 C +ATOM 3200 CD2 PHE B 199 62.059 45.763 26.899 1.00 26.67 C +ATOM 3201 CE1 PHE B 199 59.966 43.966 27.095 1.00 15.30 C +ATOM 3202 CE2 PHE B 199 62.249 44.447 26.536 1.00 21.02 C +ATOM 3203 CZ PHE B 199 61.202 43.545 26.635 1.00 18.76 C +ATOM 3204 N THR B 200 61.126 50.292 29.186 1.00 13.44 N +ATOM 3205 CA THR B 200 60.788 51.694 29.380 1.00 13.99 C +ATOM 3206 C THR B 200 60.531 52.276 27.986 1.00 15.43 C +ATOM 3207 O THR B 200 61.432 52.312 27.146 1.00 26.39 O +ATOM 3208 CB THR B 200 61.964 52.457 30.058 1.00 17.32 C +ATOM 3209 OG1 THR B 200 62.287 51.825 31.305 1.00 32.25 O +ATOM 3210 CG2 THR B 200 61.599 53.898 30.314 1.00 8.50 C +ATOM 3211 N LYS B 201 59.296 52.676 27.722 1.00 13.40 N +ATOM 3212 CA LYS B 201 58.928 53.247 26.434 1.00 9.56 C +ATOM 3213 C LYS B 201 58.151 54.566 26.644 1.00 13.52 C +ATOM 3214 O LYS B 201 57.777 54.900 27.778 1.00 13.91 O +ATOM 3215 CB LYS B 201 58.080 52.243 25.641 1.00 9.61 C +ATOM 3216 CG LYS B 201 58.816 50.997 25.171 1.00 8.61 C +ATOM 3217 CD LYS B 201 60.099 51.328 24.429 1.00 19.10 C +ATOM 3218 CE LYS B 201 60.492 50.231 23.448 1.00 27.90 C +ATOM 3219 NZ LYS B 201 59.520 50.130 22.305 1.00 32.44 N +ATOM 3220 N PRO B 202 57.943 55.358 25.570 1.00 13.05 N +ATOM 3221 CA PRO B 202 57.219 56.631 25.655 1.00 8.58 C +ATOM 3222 C PRO B 202 55.782 56.368 26.035 1.00 8.96 C +ATOM 3223 O PRO B 202 55.181 55.465 25.505 1.00 14.33 O +ATOM 3224 CB PRO B 202 57.311 57.157 24.237 1.00 9.50 C +ATOM 3225 CG PRO B 202 58.578 56.563 23.730 1.00 14.34 C +ATOM 3226 CD PRO B 202 58.469 55.162 24.210 1.00 20.15 C +ATOM 3227 N GLN B 203 55.225 57.171 26.928 1.00 8.50 N +ATOM 3228 CA GLN B 203 53.845 56.980 27.363 1.00 9.50 C +ATOM 3229 C GLN B 203 52.801 57.203 26.270 1.00 8.88 C +ATOM 3230 O GLN B 203 52.920 58.111 25.453 1.00 10.22 O +ATOM 3231 CB GLN B 203 53.540 57.886 28.541 1.00 19.01 C +ATOM 3232 CG GLN B 203 53.704 59.351 28.244 1.00 12.16 C +ATOM 3233 CD GLN B 203 53.314 60.185 29.418 1.00 27.88 C +ATOM 3234 OE1 GLN B 203 52.542 61.131 29.281 1.00 39.59 O +ATOM 3235 NE2 GLN B 203 53.826 59.827 30.609 1.00 38.61 N +ATOM 3236 N LEU B 204 51.754 56.392 26.302 1.00 8.50 N +ATOM 3237 CA LEU B 204 50.695 56.470 25.315 1.00 8.50 C +ATOM 3238 C LEU B 204 49.627 57.484 25.654 1.00 11.77 C +ATOM 3239 O LEU B 204 48.918 57.982 24.770 1.00 12.81 O +ATOM 3240 CB LEU B 204 50.053 55.098 25.135 1.00 21.36 C +ATOM 3241 CG LEU B 204 51.058 53.993 24.821 1.00 18.74 C +ATOM 3242 CD1 LEU B 204 51.362 53.292 26.127 1.00 22.82 C +ATOM 3243 CD2 LEU B 204 50.505 53.026 23.787 1.00 14.41 C +ATOM 3244 N TRP B 205 49.428 57.703 26.947 1.00 15.92 N +ATOM 3245 CA TRP B 205 48.460 58.697 27.395 1.00 19.32 C +ATOM 3246 C TRP B 205 49.162 60.043 27.260 1.00 26.84 C +ATOM 3247 O TRP B 205 50.401 60.118 27.343 1.00 32.96 O +ATOM 3248 CB TRP B 205 48.036 58.464 28.851 1.00 16.44 C +ATOM 3249 CG TRP B 205 49.166 58.131 29.792 1.00 21.41 C +ATOM 3250 CD1 TRP B 205 49.973 59.006 30.467 1.00 16.96 C +ATOM 3251 CD2 TRP B 205 49.606 56.814 30.159 1.00 21.07 C +ATOM 3252 NE1 TRP B 205 50.883 58.312 31.231 1.00 16.58 N +ATOM 3253 CE2 TRP B 205 50.679 56.968 31.056 1.00 17.53 C +ATOM 3254 CE3 TRP B 205 49.193 55.517 29.810 1.00 16.72 C +ATOM 3255 CZ2 TRP B 205 51.344 55.879 31.605 1.00 21.68 C +ATOM 3256 CZ3 TRP B 205 49.850 54.446 30.354 1.00 14.76 C +ATOM 3257 CH2 TRP B 205 50.915 54.628 31.241 1.00 17.55 C +ATOM 3258 N PRO B 206 48.390 61.106 26.975 1.00 29.16 N +ATOM 3259 CA PRO B 206 48.939 62.453 26.817 1.00 30.94 C +ATOM 3260 C PRO B 206 49.269 63.154 28.148 1.00 36.49 C +ATOM 3261 O PRO B 206 50.209 63.983 28.154 1.00 37.36 O +ATOM 3262 CB PRO B 206 47.832 63.155 26.054 1.00 26.75 C +ATOM 3263 CG PRO B 206 46.600 62.545 26.650 1.00 26.45 C +ATOM 3264 CD PRO B 206 46.949 61.088 26.661 1.00 29.87 C +ATOM 3265 OXT PRO B 206 48.591 62.873 29.167 1.00 44.00 O +TER 3266 PRO B 206 +ATOM 3267 N GLN C 1 57.051 56.404 -9.197 1.00 61.27 N +ATOM 3268 CA GLN C 1 57.361 57.802 -8.795 1.00 52.39 C +ATOM 3269 C GLN C 1 56.128 58.644 -9.105 1.00 51.68 C +ATOM 3270 O GLN C 1 56.174 59.555 -9.932 1.00 58.28 O +ATOM 3271 CB GLN C 1 58.558 58.302 -9.609 1.00 48.67 C +ATOM 3272 CG GLN C 1 59.909 58.087 -8.968 1.00 42.37 C +ATOM 3273 CD GLN C 1 60.206 59.135 -7.915 1.00 52.04 C +ATOM 3274 OE1 GLN C 1 60.464 58.813 -6.760 1.00 64.64 O +ATOM 3275 NE2 GLN C 1 60.155 60.401 -8.307 1.00 46.56 N +ATOM 3276 N THR C 2 55.017 58.315 -8.466 1.00 41.75 N +ATOM 3277 CA THR C 2 53.788 59.036 -8.710 1.00 34.64 C +ATOM 3278 C THR C 2 53.322 59.652 -7.410 1.00 33.69 C +ATOM 3279 O THR C 2 53.449 59.035 -6.352 1.00 38.10 O +ATOM 3280 CB THR C 2 52.704 58.085 -9.224 1.00 31.61 C +ATOM 3281 OG1 THR C 2 53.244 57.287 -10.283 1.00 47.39 O +ATOM 3282 CG2 THR C 2 51.505 58.859 -9.745 1.00 40.08 C +ATOM 3283 N ASP C 3 52.840 60.889 -7.475 1.00 29.91 N +ATOM 3284 CA ASP C 3 52.339 61.548 -6.288 1.00 22.80 C +ATOM 3285 C ASP C 3 50.900 61.089 -6.135 1.00 25.59 C +ATOM 3286 O ASP C 3 49.994 61.604 -6.803 1.00 25.62 O +ATOM 3287 CB ASP C 3 52.400 63.064 -6.433 1.00 26.56 C +ATOM 3288 CG ASP C 3 52.302 63.778 -5.099 1.00 26.53 C +ATOM 3289 OD1 ASP C 3 51.927 63.142 -4.103 1.00 20.20 O +ATOM 3290 OD2 ASP C 3 52.616 64.978 -5.037 1.00 40.28 O +ATOM 3291 N MET C 4 50.705 60.089 -5.277 1.00 23.24 N +ATOM 3292 CA MET C 4 49.383 59.525 -5.033 1.00 18.25 C +ATOM 3293 C MET C 4 48.522 60.347 -4.069 1.00 15.51 C +ATOM 3294 O MET C 4 47.481 59.884 -3.596 1.00 14.51 O +ATOM 3295 CB MET C 4 49.515 58.085 -4.540 1.00 8.50 C +ATOM 3296 CG MET C 4 49.944 57.121 -5.609 1.00 8.50 C +ATOM 3297 SD MET C 4 48.811 57.147 -7.013 1.00 12.05 S +ATOM 3298 CE MET C 4 47.494 56.132 -6.390 1.00 8.50 C +ATOM 3299 N SER C 5 48.942 61.580 -3.808 1.00 12.92 N +ATOM 3300 CA SER C 5 48.227 62.477 -2.902 1.00 13.93 C +ATOM 3301 C SER C 5 46.775 62.683 -3.280 1.00 16.89 C +ATOM 3302 O SER C 5 46.459 62.940 -4.448 1.00 23.73 O +ATOM 3303 CB SER C 5 48.908 63.851 -2.833 1.00 8.99 C +ATOM 3304 OG SER C 5 50.096 63.807 -2.068 1.00 24.66 O +ATOM 3305 N ARG C 6 45.904 62.603 -2.275 1.00 16.83 N +ATOM 3306 CA ARG C 6 44.470 62.814 -2.467 1.00 14.72 C +ATOM 3307 C ARG C 6 43.802 61.701 -3.269 1.00 14.54 C +ATOM 3308 O ARG C 6 42.632 61.825 -3.646 1.00 15.94 O +ATOM 3309 CB ARG C 6 44.243 64.141 -3.218 1.00 30.06 C +ATOM 3310 CG ARG C 6 43.632 65.301 -2.437 1.00 41.43 C +ATOM 3311 CD ARG C 6 44.520 65.820 -1.311 1.00 20.40 C +ATOM 3312 NE ARG C 6 43.782 66.741 -0.447 1.00 36.07 N +ATOM 3313 CZ ARG C 6 42.607 66.476 0.133 1.00 37.71 C +ATOM 3314 NH1 ARG C 6 41.993 65.312 -0.037 1.00 46.15 N +ATOM 3315 NH2 ARG C 6 42.030 67.387 0.897 1.00 52.93 N +ATOM 3316 N LYS C 7 44.533 60.613 -3.510 1.00 14.65 N +ATOM 3317 CA LYS C 7 44.005 59.488 -4.280 1.00 12.27 C +ATOM 3318 C LYS C 7 43.960 58.186 -3.481 1.00 11.95 C +ATOM 3319 O LYS C 7 44.586 58.064 -2.416 1.00 9.82 O +ATOM 3320 CB LYS C 7 44.804 59.306 -5.572 1.00 19.28 C +ATOM 3321 CG LYS C 7 44.585 60.416 -6.599 1.00 21.68 C +ATOM 3322 CD LYS C 7 45.717 60.503 -7.590 1.00 28.24 C +ATOM 3323 CE LYS C 7 45.521 61.669 -8.525 1.00 40.91 C +ATOM 3324 NZ LYS C 7 46.742 61.856 -9.366 1.00 63.65 N +ATOM 3325 N ALA C 8 43.182 57.234 -3.983 1.00 9.49 N +ATOM 3326 CA ALA C 8 43.023 55.956 -3.328 1.00 8.50 C +ATOM 3327 C ALA C 8 42.813 54.911 -4.404 1.00 8.50 C +ATOM 3328 O ALA C 8 42.303 55.231 -5.470 1.00 9.07 O +ATOM 3329 CB ALA C 8 41.812 56.008 -2.394 1.00 8.50 C +ATOM 3330 N PHE C 9 43.275 53.687 -4.152 1.00 10.06 N +ATOM 3331 CA PHE C 9 43.082 52.582 -5.085 1.00 8.84 C +ATOM 3332 C PHE C 9 41.730 52.021 -4.693 1.00 9.80 C +ATOM 3333 O PHE C 9 41.439 51.896 -3.499 1.00 8.91 O +ATOM 3334 CB PHE C 9 44.125 51.494 -4.877 1.00 8.50 C +ATOM 3335 CG PHE C 9 45.517 51.885 -5.285 1.00 8.50 C +ATOM 3336 CD1 PHE C 9 45.802 52.224 -6.600 1.00 8.50 C +ATOM 3337 CD2 PHE C 9 46.563 51.857 -4.362 1.00 8.50 C +ATOM 3338 CE1 PHE C 9 47.102 52.522 -6.981 1.00 8.50 C +ATOM 3339 CE2 PHE C 9 47.862 52.151 -4.739 1.00 8.50 C +ATOM 3340 CZ PHE C 9 48.132 52.482 -6.046 1.00 8.50 C +ATOM 3341 N VAL C 10 40.892 51.715 -5.675 1.00 9.22 N +ATOM 3342 CA VAL C 10 39.574 51.171 -5.379 1.00 11.51 C +ATOM 3343 C VAL C 10 39.281 49.857 -6.117 1.00 10.67 C +ATOM 3344 O VAL C 10 39.363 49.790 -7.337 1.00 10.27 O +ATOM 3345 CB VAL C 10 38.444 52.253 -5.573 1.00 13.35 C +ATOM 3346 CG1 VAL C 10 38.839 53.258 -6.641 1.00 14.32 C +ATOM 3347 CG2 VAL C 10 37.103 51.604 -5.897 1.00 8.50 C +ATOM 3348 N PHE C 11 39.029 48.802 -5.339 1.00 11.90 N +ATOM 3349 CA PHE C 11 38.702 47.447 -5.822 1.00 8.57 C +ATOM 3350 C PHE C 11 37.179 47.305 -5.681 1.00 11.86 C +ATOM 3351 O PHE C 11 36.671 46.911 -4.626 1.00 9.92 O +ATOM 3352 CB PHE C 11 39.390 46.422 -4.928 1.00 8.50 C +ATOM 3353 CG PHE C 11 40.856 46.654 -4.764 1.00 8.50 C +ATOM 3354 CD1 PHE C 11 41.760 46.120 -5.671 1.00 8.50 C +ATOM 3355 CD2 PHE C 11 41.337 47.399 -3.704 1.00 8.50 C +ATOM 3356 CE1 PHE C 11 43.126 46.321 -5.528 1.00 8.50 C +ATOM 3357 CE2 PHE C 11 42.707 47.609 -3.548 1.00 13.10 C +ATOM 3358 CZ PHE C 11 43.604 47.064 -4.466 1.00 11.43 C +ATOM 3359 N PRO C 12 36.434 47.611 -6.749 1.00 11.38 N +ATOM 3360 CA PRO C 12 34.970 47.563 -6.791 1.00 12.81 C +ATOM 3361 C PRO C 12 34.295 46.230 -6.590 1.00 21.25 C +ATOM 3362 O PRO C 12 33.158 46.185 -6.112 1.00 31.70 O +ATOM 3363 CB PRO C 12 34.639 48.135 -8.170 1.00 11.69 C +ATOM 3364 CG PRO C 12 35.859 48.925 -8.523 1.00 17.64 C +ATOM 3365 CD PRO C 12 36.963 48.034 -8.045 1.00 10.13 C +ATOM 3366 N LYS C 13 34.927 45.146 -7.019 1.00 28.42 N +ATOM 3367 CA LYS C 13 34.300 43.841 -6.851 1.00 32.76 C +ATOM 3368 C LYS C 13 35.217 42.717 -6.415 1.00 32.86 C +ATOM 3369 O LYS C 13 36.443 42.794 -6.589 1.00 30.79 O +ATOM 3370 CB LYS C 13 33.472 43.446 -8.077 1.00 29.36 C +ATOM 3371 CG LYS C 13 34.128 43.650 -9.430 1.00 41.52 C +ATOM 3372 CD LYS C 13 33.104 43.376 -10.545 1.00 55.00 C +ATOM 3373 CE LYS C 13 33.622 43.726 -11.941 1.00 60.98 C +ATOM 3374 NZ LYS C 13 34.769 42.879 -12.373 1.00 69.27 N +ATOM 3375 N GLU C 14 34.605 41.694 -5.815 1.00 33.91 N +ATOM 3376 CA GLU C 14 35.328 40.533 -5.307 1.00 42.15 C +ATOM 3377 C GLU C 14 36.066 39.850 -6.434 1.00 43.01 C +ATOM 3378 O GLU C 14 35.469 39.422 -7.421 1.00 45.15 O +ATOM 3379 CB GLU C 14 34.390 39.543 -4.592 1.00 45.45 C +ATOM 3380 CG GLU C 14 35.116 38.421 -3.828 1.00 37.51 C +ATOM 3381 CD GLU C 14 34.172 37.520 -3.059 1.00 43.92 C +ATOM 3382 OE1 GLU C 14 33.566 37.997 -2.073 1.00 44.37 O +ATOM 3383 OE2 GLU C 14 34.045 36.334 -3.439 1.00 49.96 O +ATOM 3384 N SER C 15 37.381 39.776 -6.295 1.00 46.87 N +ATOM 3385 CA SER C 15 38.208 39.161 -7.315 1.00 44.87 C +ATOM 3386 C SER C 15 39.215 38.148 -6.789 1.00 43.39 C +ATOM 3387 O SER C 15 39.375 37.935 -5.577 1.00 39.96 O +ATOM 3388 CB SER C 15 38.909 40.242 -8.154 1.00 50.42 C +ATOM 3389 OG SER C 15 39.577 41.204 -7.345 1.00 54.18 O +ATOM 3390 N ASP C 16 39.849 37.499 -7.746 1.00 43.41 N +ATOM 3391 CA ASP C 16 40.843 36.477 -7.515 1.00 45.24 C +ATOM 3392 C ASP C 16 42.096 37.019 -8.183 1.00 42.66 C +ATOM 3393 O ASP C 16 43.211 36.602 -7.875 1.00 39.46 O +ATOM 3394 CB ASP C 16 40.371 35.220 -8.266 1.00 58.52 C +ATOM 3395 CG ASP C 16 40.942 33.922 -7.708 1.00 69.27 C +ATOM 3396 OD1 ASP C 16 41.324 33.873 -6.516 1.00 77.90 O +ATOM 3397 OD2 ASP C 16 40.966 32.930 -8.471 1.00 65.80 O +ATOM 3398 N THR C 17 41.882 38.012 -9.049 1.00 42.69 N +ATOM 3399 CA THR C 17 42.922 38.631 -9.872 1.00 39.99 C +ATOM 3400 C THR C 17 43.380 40.076 -9.617 1.00 40.14 C +ATOM 3401 O THR C 17 44.460 40.466 -10.070 1.00 41.40 O +ATOM 3402 CB THR C 17 42.470 38.556 -11.326 1.00 39.60 C +ATOM 3403 OG1 THR C 17 41.120 39.039 -11.426 1.00 37.37 O +ATOM 3404 CG2 THR C 17 42.492 37.116 -11.808 1.00 52.10 C +ATOM 3405 N SER C 18 42.555 40.879 -8.947 1.00 37.23 N +ATOM 3406 CA SER C 18 42.895 42.276 -8.692 1.00 22.21 C +ATOM 3407 C SER C 18 43.821 42.498 -7.509 1.00 18.59 C +ATOM 3408 O SER C 18 43.621 41.912 -6.438 1.00 17.69 O +ATOM 3409 CB SER C 18 41.621 43.092 -8.509 1.00 19.13 C +ATOM 3410 OG SER C 18 40.761 42.931 -9.620 1.00 17.64 O +ATOM 3411 N TYR C 19 44.840 43.329 -7.724 1.00 8.50 N +ATOM 3412 CA TYR C 19 45.805 43.687 -6.693 1.00 12.01 C +ATOM 3413 C TYR C 19 46.755 44.755 -7.196 1.00 13.12 C +ATOM 3414 O TYR C 19 46.814 45.010 -8.393 1.00 11.80 O +ATOM 3415 CB TYR C 19 46.605 42.479 -6.218 1.00 18.58 C +ATOM 3416 CG TYR C 19 47.581 41.927 -7.230 1.00 26.03 C +ATOM 3417 CD1 TYR C 19 48.884 42.415 -7.310 1.00 20.35 C +ATOM 3418 CD2 TYR C 19 47.209 40.889 -8.087 1.00 29.67 C +ATOM 3419 CE1 TYR C 19 49.788 41.888 -8.213 1.00 25.78 C +ATOM 3420 CE2 TYR C 19 48.105 40.352 -8.990 1.00 29.49 C +ATOM 3421 CZ TYR C 19 49.396 40.857 -9.047 1.00 30.97 C +ATOM 3422 OH TYR C 19 50.313 40.326 -9.927 1.00 46.79 O +ATOM 3423 N VAL C 20 47.477 45.394 -6.273 1.00 16.20 N +ATOM 3424 CA VAL C 20 48.443 46.438 -6.605 1.00 9.35 C +ATOM 3425 C VAL C 20 49.730 46.081 -5.916 1.00 13.03 C +ATOM 3426 O VAL C 20 49.749 45.844 -4.710 1.00 17.78 O +ATOM 3427 CB VAL C 20 48.013 47.794 -6.084 1.00 8.50 C +ATOM 3428 CG1 VAL C 20 49.097 48.820 -6.373 1.00 15.95 C +ATOM 3429 CG2 VAL C 20 46.707 48.201 -6.727 1.00 8.50 C +ATOM 3430 N SER C 21 50.796 46.005 -6.691 1.00 16.89 N +ATOM 3431 CA SER C 21 52.104 45.651 -6.167 1.00 19.30 C +ATOM 3432 C SER C 21 52.891 46.912 -5.877 1.00 13.83 C +ATOM 3433 O SER C 21 52.968 47.802 -6.710 1.00 17.41 O +ATOM 3434 CB SER C 21 52.857 44.778 -7.177 1.00 27.89 C +ATOM 3435 OG SER C 21 54.119 44.379 -6.675 1.00 42.17 O +ATOM 3436 N LEU C 22 53.454 46.985 -4.683 1.00 8.62 N +ATOM 3437 CA LEU C 22 54.238 48.119 -4.260 1.00 12.30 C +ATOM 3438 C LEU C 22 55.717 47.734 -4.284 1.00 21.32 C +ATOM 3439 O LEU C 22 56.114 46.690 -3.747 1.00 22.21 O +ATOM 3440 CB LEU C 22 53.799 48.550 -2.853 1.00 10.53 C +ATOM 3441 CG LEU C 22 52.787 49.704 -2.701 1.00 14.39 C +ATOM 3442 CD1 LEU C 22 51.680 49.670 -3.721 1.00 8.50 C +ATOM 3443 CD2 LEU C 22 52.217 49.674 -1.308 1.00 15.26 C +ATOM 3444 N LYS C 23 56.523 48.575 -4.933 1.00 29.45 N +ATOM 3445 CA LYS C 23 57.964 48.355 -5.064 1.00 34.50 C +ATOM 3446 C LYS C 23 58.751 49.203 -4.064 1.00 38.04 C +ATOM 3447 O LYS C 23 58.753 50.439 -4.139 1.00 36.40 O +ATOM 3448 CB LYS C 23 58.420 48.711 -6.491 1.00 43.08 C +ATOM 3449 CG LYS C 23 57.611 48.044 -7.615 1.00 61.96 C +ATOM 3450 CD LYS C 23 57.893 46.534 -7.740 1.00 73.22 C +ATOM 3451 CE LYS C 23 57.122 45.887 -8.909 1.00 77.20 C +ATOM 3452 NZ LYS C 23 55.640 45.808 -8.680 1.00 81.22 N +ATOM 3453 N ALA C 24 59.409 48.535 -3.126 1.00 46.07 N +ATOM 3454 CA ALA C 24 60.206 49.222 -2.120 1.00 54.66 C +ATOM 3455 C ALA C 24 61.669 48.946 -2.399 1.00 64.76 C +ATOM 3456 O ALA C 24 62.055 47.802 -2.643 1.00 71.52 O +ATOM 3457 CB ALA C 24 59.841 48.727 -0.739 1.00 54.53 C +ATOM 3458 N PRO C 25 62.495 49.997 -2.422 1.00 71.76 N +ATOM 3459 CA PRO C 25 63.932 49.854 -2.677 1.00 78.06 C +ATOM 3460 C PRO C 25 64.677 49.539 -1.387 1.00 79.54 C +ATOM 3461 O PRO C 25 65.476 50.339 -0.891 1.00 78.79 O +ATOM 3462 CB PRO C 25 64.306 51.224 -3.234 1.00 84.16 C +ATOM 3463 CG PRO C 25 63.413 52.140 -2.459 1.00 79.48 C +ATOM 3464 CD PRO C 25 62.089 51.411 -2.436 1.00 73.00 C +ATOM 3465 N LEU C 26 64.406 48.356 -0.852 1.00 81.55 N +ATOM 3466 CA LEU C 26 65.016 47.920 0.393 1.00 82.89 C +ATOM 3467 C LEU C 26 66.343 47.195 0.170 1.00 85.38 C +ATOM 3468 O LEU C 26 66.481 46.390 -0.757 1.00 84.81 O +ATOM 3469 CB LEU C 26 64.026 47.044 1.164 1.00 79.35 C +ATOM 3470 CG LEU C 26 63.822 47.331 2.653 1.00 72.37 C +ATOM 3471 CD1 LEU C 26 63.861 48.825 2.941 1.00 73.36 C +ATOM 3472 CD2 LEU C 26 62.500 46.726 3.083 1.00 66.99 C +ATOM 3473 N THR C 27 67.321 47.525 1.013 1.00 87.79 N +ATOM 3474 CA THR C 27 68.660 46.942 0.950 1.00 87.66 C +ATOM 3475 C THR C 27 68.997 46.209 2.248 1.00 81.49 C +ATOM 3476 O THR C 27 69.503 45.087 2.232 1.00 81.17 O +ATOM 3477 CB THR C 27 69.735 48.039 0.695 1.00 91.21 C +ATOM 3478 OG1 THR C 27 69.539 49.131 1.607 1.00 93.10 O +ATOM 3479 CG2 THR C 27 69.655 48.556 -0.743 1.00 94.21 C +ATOM 3480 N LYS C 28 68.745 46.877 3.369 1.00 75.89 N +ATOM 3481 CA LYS C 28 69.000 46.319 4.695 1.00 70.18 C +ATOM 3482 C LYS C 28 67.747 45.629 5.206 1.00 59.71 C +ATOM 3483 O LYS C 28 66.637 46.063 4.912 1.00 66.07 O +ATOM 3484 CB LYS C 28 69.376 47.438 5.682 1.00 78.51 C +ATOM 3485 CG LYS C 28 70.812 47.956 5.588 1.00 89.96 C +ATOM 3486 CD LYS C 28 71.803 46.984 6.222 1.00 96.37 C +ATOM 3487 CE LYS C 28 73.227 47.527 6.188 1.00 99.39 C +ATOM 3488 NZ LYS C 28 74.178 46.617 6.887 1.00103.41 N +ATOM 3489 N PRO C 29 67.901 44.502 5.906 1.00 47.87 N +ATOM 3490 CA PRO C 29 66.745 43.783 6.445 1.00 44.46 C +ATOM 3491 C PRO C 29 66.175 44.570 7.642 1.00 39.53 C +ATOM 3492 O PRO C 29 66.925 45.226 8.380 1.00 37.48 O +ATOM 3493 CB PRO C 29 67.340 42.431 6.844 1.00 46.24 C +ATOM 3494 CG PRO C 29 68.754 42.780 7.185 1.00 51.96 C +ATOM 3495 CD PRO C 29 69.133 43.718 6.073 1.00 49.55 C +ATOM 3496 N LEU C 30 64.856 44.516 7.821 1.00 32.54 N +ATOM 3497 CA LEU C 30 64.193 45.271 8.888 1.00 24.44 C +ATOM 3498 C LEU C 30 64.322 44.716 10.308 1.00 22.22 C +ATOM 3499 O LEU C 30 64.058 43.532 10.559 1.00 16.46 O +ATOM 3500 CB LEU C 30 62.703 45.483 8.562 1.00 22.59 C +ATOM 3501 CG LEU C 30 62.227 46.341 7.384 1.00 8.68 C +ATOM 3502 CD1 LEU C 30 63.316 47.275 6.914 1.00 13.86 C +ATOM 3503 CD2 LEU C 30 61.786 45.462 6.265 1.00 11.28 C +ATOM 3504 N LYS C 31 64.681 45.608 11.232 1.00 20.70 N +ATOM 3505 CA LYS C 31 64.835 45.291 12.658 1.00 18.99 C +ATOM 3506 C LYS C 31 63.710 45.961 13.453 1.00 18.41 C +ATOM 3507 O LYS C 31 63.621 45.822 14.680 1.00 14.13 O +ATOM 3508 CB LYS C 31 66.198 45.785 13.162 1.00 21.20 C +ATOM 3509 CG LYS C 31 67.363 44.872 12.808 1.00 44.83 C +ATOM 3510 CD LYS C 31 67.256 43.541 13.564 1.00 64.81 C +ATOM 3511 CE LYS C 31 68.358 42.554 13.173 1.00 72.66 C +ATOM 3512 NZ LYS C 31 68.226 41.264 13.916 1.00 76.87 N +ATOM 3513 N ALA C 32 62.885 46.718 12.729 1.00 20.57 N +ATOM 3514 CA ALA C 32 61.742 47.466 13.253 1.00 12.15 C +ATOM 3515 C ALA C 32 61.046 48.096 12.047 1.00 8.76 C +ATOM 3516 O ALA C 32 61.593 48.113 10.964 1.00 11.81 O +ATOM 3517 CB ALA C 32 62.205 48.556 14.200 1.00 14.82 C +ATOM 3518 N PHE C 33 59.830 48.580 12.225 1.00 10.29 N +ATOM 3519 CA PHE C 33 59.090 49.203 11.137 1.00 8.90 C +ATOM 3520 C PHE C 33 57.765 49.780 11.643 1.00 14.95 C +ATOM 3521 O PHE C 33 57.305 49.441 12.744 1.00 15.04 O +ATOM 3522 CB PHE C 33 58.820 48.199 10.013 1.00 8.50 C +ATOM 3523 CG PHE C 33 57.922 47.046 10.408 1.00 12.48 C +ATOM 3524 CD1 PHE C 33 56.536 47.136 10.268 1.00 13.66 C +ATOM 3525 CD2 PHE C 33 58.459 45.857 10.879 1.00 13.97 C +ATOM 3526 CE1 PHE C 33 55.701 46.060 10.587 1.00 8.50 C +ATOM 3527 CE2 PHE C 33 57.625 44.785 11.195 1.00 16.34 C +ATOM 3528 CZ PHE C 33 56.241 44.894 11.045 1.00 8.50 C +ATOM 3529 N THR C 34 57.188 50.690 10.859 1.00 13.70 N +ATOM 3530 CA THR C 34 55.904 51.318 11.173 1.00 9.50 C +ATOM 3531 C THR C 34 55.233 51.428 9.840 1.00 10.72 C +ATOM 3532 O THR C 34 55.851 51.901 8.879 1.00 12.72 O +ATOM 3533 CB THR C 34 56.036 52.776 11.682 1.00 8.50 C +ATOM 3534 OG1 THR C 34 56.885 52.825 12.827 1.00 16.80 O +ATOM 3535 CG2 THR C 34 54.682 53.317 12.070 1.00 8.50 C +ATOM 3536 N VAL C 35 54.006 50.937 9.750 1.00 10.64 N +ATOM 3537 CA VAL C 35 53.256 51.028 8.505 1.00 10.16 C +ATOM 3538 C VAL C 35 51.887 51.575 8.844 1.00 10.61 C +ATOM 3539 O VAL C 35 51.232 51.098 9.761 1.00 12.07 O +ATOM 3540 CB VAL C 35 53.175 49.676 7.735 1.00 8.50 C +ATOM 3541 CG1 VAL C 35 53.475 48.511 8.643 1.00 10.07 C +ATOM 3542 CG2 VAL C 35 51.820 49.512 7.092 1.00 8.56 C +ATOM 3543 N CYS C 36 51.517 52.653 8.169 1.00 12.60 N +ATOM 3544 CA CYS C 36 50.237 53.309 8.381 1.00 11.02 C +ATOM 3545 C CYS C 36 49.490 53.282 7.063 1.00 10.66 C +ATOM 3546 O CYS C 36 50.113 53.261 6.000 1.00 15.16 O +ATOM 3547 CB CYS C 36 50.465 54.761 8.811 1.00 12.34 C +ATOM 3548 SG CYS C 36 51.421 54.968 10.352 1.00 15.82 S +ATOM 3549 N LEU C 37 48.165 53.241 7.127 1.00 10.52 N +ATOM 3550 CA LEU C 37 47.332 53.243 5.915 1.00 11.48 C +ATOM 3551 C LEU C 37 45.878 53.585 6.241 1.00 11.48 C +ATOM 3552 O LEU C 37 45.458 53.580 7.408 1.00 11.59 O +ATOM 3553 CB LEU C 37 47.428 51.897 5.184 1.00 11.03 C +ATOM 3554 CG LEU C 37 47.023 50.616 5.903 1.00 8.50 C +ATOM 3555 CD1 LEU C 37 45.552 50.337 5.673 1.00 8.50 C +ATOM 3556 CD2 LEU C 37 47.833 49.491 5.353 1.00 8.50 C +ATOM 3557 N HIS C 38 45.118 53.897 5.208 1.00 8.50 N +ATOM 3558 CA HIS C 38 43.715 54.256 5.352 1.00 9.44 C +ATOM 3559 C HIS C 38 42.951 53.254 4.493 1.00 11.44 C +ATOM 3560 O HIS C 38 43.337 53.008 3.353 1.00 19.51 O +ATOM 3561 CB HIS C 38 43.505 55.645 4.741 1.00 13.00 C +ATOM 3562 CG HIS C 38 42.991 56.686 5.687 1.00 14.14 C +ATOM 3563 ND1 HIS C 38 43.686 57.849 5.958 1.00 10.85 N +ATOM 3564 CD2 HIS C 38 41.810 56.790 6.348 1.00 15.79 C +ATOM 3565 CE1 HIS C 38 42.954 58.624 6.742 1.00 19.46 C +ATOM 3566 NE2 HIS C 38 41.811 58.005 6.992 1.00 15.74 N +ATOM 3567 N PHE C 39 41.890 52.662 5.013 1.00 8.76 N +ATOM 3568 CA PHE C 39 41.119 51.738 4.206 1.00 8.50 C +ATOM 3569 C PHE C 39 39.665 51.950 4.519 1.00 8.50 C +ATOM 3570 O PHE C 39 39.324 52.526 5.543 1.00 8.50 O +ATOM 3571 CB PHE C 39 41.556 50.285 4.429 1.00 12.95 C +ATOM 3572 CG PHE C 39 41.141 49.695 5.757 1.00 8.50 C +ATOM 3573 CD1 PHE C 39 41.928 49.867 6.885 1.00 8.50 C +ATOM 3574 CD2 PHE C 39 39.977 48.936 5.860 1.00 8.50 C +ATOM 3575 CE1 PHE C 39 41.569 49.297 8.095 1.00 8.50 C +ATOM 3576 CE2 PHE C 39 39.620 48.372 7.047 1.00 8.50 C +ATOM 3577 CZ PHE C 39 40.417 48.550 8.175 1.00 8.50 C +ATOM 3578 N TYR C 40 38.806 51.520 3.617 1.00 8.50 N +ATOM 3579 CA TYR C 40 37.378 51.688 3.805 1.00 10.28 C +ATOM 3580 C TYR C 40 36.636 50.557 3.091 1.00 9.99 C +ATOM 3581 O TYR C 40 36.555 50.552 1.865 1.00 9.02 O +ATOM 3582 CB TYR C 40 36.968 53.056 3.246 1.00 8.50 C +ATOM 3583 CG TYR C 40 35.497 53.382 3.395 1.00 9.44 C +ATOM 3584 CD1 TYR C 40 34.736 52.787 4.390 1.00 13.36 C +ATOM 3585 CD2 TYR C 40 34.868 54.284 2.542 1.00 8.50 C +ATOM 3586 CE1 TYR C 40 33.391 53.081 4.535 1.00 12.14 C +ATOM 3587 CE2 TYR C 40 33.521 54.583 2.683 1.00 8.50 C +ATOM 3588 CZ TYR C 40 32.794 53.977 3.686 1.00 8.50 C +ATOM 3589 OH TYR C 40 31.474 54.265 3.886 1.00 8.50 O +ATOM 3590 N THR C 41 36.087 49.617 3.859 1.00 9.83 N +ATOM 3591 CA THR C 41 35.369 48.486 3.289 1.00 10.79 C +ATOM 3592 C THR C 41 34.099 48.124 4.055 1.00 15.14 C +ATOM 3593 O THR C 41 33.909 48.546 5.194 1.00 14.11 O +ATOM 3594 CB THR C 41 36.259 47.256 3.220 1.00 11.71 C +ATOM 3595 OG1 THR C 41 35.544 46.192 2.576 1.00 23.29 O +ATOM 3596 CG2 THR C 41 36.660 46.815 4.610 1.00 8.93 C +ATOM 3597 N GLU C 42 33.257 47.298 3.440 1.00 18.69 N +ATOM 3598 CA GLU C 42 31.994 46.888 4.045 1.00 24.14 C +ATOM 3599 C GLU C 42 31.978 45.394 4.378 1.00 26.32 C +ATOM 3600 O GLU C 42 30.949 44.832 4.713 1.00 30.86 O +ATOM 3601 CB GLU C 42 30.865 47.197 3.069 1.00 28.12 C +ATOM 3602 CG GLU C 42 29.589 47.748 3.701 1.00 44.94 C +ATOM 3603 CD GLU C 42 28.656 48.403 2.673 1.00 53.36 C +ATOM 3604 OE1 GLU C 42 27.828 47.688 2.049 1.00 57.19 O +ATOM 3605 OE2 GLU C 42 28.759 49.639 2.486 1.00 50.13 O +ATOM 3606 N LEU C 43 33.101 44.723 4.133 1.00 26.20 N +ATOM 3607 CA LEU C 43 33.244 43.278 4.368 1.00 14.79 C +ATOM 3608 C LEU C 43 33.260 42.874 5.828 1.00 17.27 C +ATOM 3609 O LEU C 43 32.829 41.790 6.157 1.00 15.06 O +ATOM 3610 CB LEU C 43 34.542 42.773 3.746 1.00 9.03 C +ATOM 3611 CG LEU C 43 34.652 42.326 2.299 1.00 8.50 C +ATOM 3612 CD1 LEU C 43 33.679 43.000 1.407 1.00 9.58 C +ATOM 3613 CD2 LEU C 43 36.051 42.593 1.866 1.00 8.50 C +ATOM 3614 N SER C 44 33.808 43.736 6.681 1.00 24.74 N +ATOM 3615 CA SER C 44 33.937 43.511 8.120 1.00 23.77 C +ATOM 3616 C SER C 44 32.870 42.641 8.788 1.00 27.57 C +ATOM 3617 O SER C 44 33.171 41.848 9.692 1.00 23.38 O +ATOM 3618 CB SER C 44 33.995 44.871 8.832 1.00 26.24 C +ATOM 3619 OG SER C 44 34.977 45.734 8.279 1.00 22.66 O +ATOM 3620 N SER C 45 31.631 42.803 8.339 1.00 33.66 N +ATOM 3621 CA SER C 45 30.484 42.093 8.894 1.00 41.54 C +ATOM 3622 C SER C 45 30.186 40.714 8.326 1.00 40.53 C +ATOM 3623 O SER C 45 29.336 39.998 8.869 1.00 48.16 O +ATOM 3624 CB SER C 45 29.228 42.957 8.752 1.00 56.62 C +ATOM 3625 OG SER C 45 29.461 44.297 9.176 1.00 75.89 O +ATOM 3626 N THR C 46 30.836 40.344 7.226 1.00 34.85 N +ATOM 3627 CA THR C 46 30.597 39.034 6.614 1.00 28.81 C +ATOM 3628 C THR C 46 31.819 38.110 6.466 1.00 26.57 C +ATOM 3629 O THR C 46 31.734 36.929 6.790 1.00 39.66 O +ATOM 3630 CB THR C 46 29.862 39.158 5.264 1.00 20.15 C +ATOM 3631 OG1 THR C 46 30.811 39.409 4.221 1.00 25.48 O +ATOM 3632 CG2 THR C 46 28.832 40.302 5.325 1.00 22.34 C +ATOM 3633 N ARG C 47 32.940 38.617 5.972 1.00 20.29 N +ATOM 3634 CA ARG C 47 34.129 37.779 5.824 1.00 19.22 C +ATOM 3635 C ARG C 47 35.431 38.470 6.255 1.00 16.62 C +ATOM 3636 O ARG C 47 35.425 39.624 6.662 1.00 20.32 O +ATOM 3637 CB ARG C 47 34.255 37.250 4.389 1.00 14.17 C +ATOM 3638 CG ARG C 47 34.688 38.265 3.338 1.00 8.88 C +ATOM 3639 CD ARG C 47 34.821 37.584 1.995 1.00 8.50 C +ATOM 3640 NE ARG C 47 35.099 38.481 0.888 1.00 8.50 N +ATOM 3641 CZ ARG C 47 36.314 38.890 0.560 1.00 17.86 C +ATOM 3642 NH1 ARG C 47 37.365 38.498 1.264 1.00 24.42 N +ATOM 3643 NH2 ARG C 47 36.494 39.650 -0.508 1.00 25.59 N +ATOM 3644 N GLY C 48 36.534 37.734 6.219 1.00 14.91 N +ATOM 3645 CA GLY C 48 37.819 38.295 6.593 1.00 10.81 C +ATOM 3646 C GLY C 48 38.461 38.812 5.330 1.00 14.53 C +ATOM 3647 O GLY C 48 37.991 38.464 4.240 1.00 25.19 O +ATOM 3648 N TYR C 49 39.521 39.610 5.447 1.00 8.50 N +ATOM 3649 CA TYR C 49 40.179 40.179 4.264 1.00 13.74 C +ATOM 3650 C TYR C 49 41.580 40.675 4.565 1.00 18.96 C +ATOM 3651 O TYR C 49 41.892 41.012 5.714 1.00 23.14 O +ATOM 3652 CB TYR C 49 39.355 41.338 3.671 1.00 16.09 C +ATOM 3653 CG TYR C 49 38.938 42.381 4.686 1.00 16.55 C +ATOM 3654 CD1 TYR C 49 39.832 43.349 5.126 1.00 18.94 C +ATOM 3655 CD2 TYR C 49 37.649 42.380 5.227 1.00 14.96 C +ATOM 3656 CE1 TYR C 49 39.449 44.290 6.084 1.00 23.46 C +ATOM 3657 CE2 TYR C 49 37.267 43.305 6.175 1.00 13.21 C +ATOM 3658 CZ TYR C 49 38.165 44.256 6.600 1.00 11.28 C +ATOM 3659 OH TYR C 49 37.770 45.177 7.535 1.00 13.03 O +ATOM 3660 N SER C 50 42.415 40.743 3.530 1.00 16.62 N +ATOM 3661 CA SER C 50 43.786 41.177 3.698 1.00 19.36 C +ATOM 3662 C SER C 50 43.930 42.659 3.453 1.00 24.44 C +ATOM 3663 O SER C 50 43.494 43.184 2.432 1.00 31.30 O +ATOM 3664 CB SER C 50 44.700 40.415 2.754 1.00 23.88 C +ATOM 3665 OG SER C 50 46.038 40.887 2.836 1.00 37.24 O +ATOM 3666 N ILE C 51 44.560 43.333 4.401 1.00 24.96 N +ATOM 3667 CA ILE C 51 44.782 44.766 4.301 1.00 16.88 C +ATOM 3668 C ILE C 51 46.172 45.057 3.726 1.00 19.09 C +ATOM 3669 O ILE C 51 46.284 45.729 2.697 1.00 23.96 O +ATOM 3670 CB ILE C 51 44.614 45.442 5.686 1.00 10.32 C +ATOM 3671 CG1 ILE C 51 43.183 45.252 6.179 1.00 13.09 C +ATOM 3672 CG2 ILE C 51 44.902 46.910 5.610 1.00 8.50 C +ATOM 3673 CD1 ILE C 51 42.967 45.720 7.599 1.00 15.69 C +ATOM 3674 N PHE C 52 47.213 44.499 4.345 1.00 12.88 N +ATOM 3675 CA PHE C 52 48.588 44.713 3.909 1.00 9.10 C +ATOM 3676 C PHE C 52 49.328 43.372 3.950 1.00 17.01 C +ATOM 3677 O PHE C 52 49.366 42.732 5.000 1.00 18.68 O +ATOM 3678 CB PHE C 52 49.238 45.710 4.858 1.00 8.50 C +ATOM 3679 CG PHE C 52 50.595 46.176 4.436 1.00 8.50 C +ATOM 3680 CD1 PHE C 52 50.749 47.069 3.397 1.00 8.55 C +ATOM 3681 CD2 PHE C 52 51.724 45.764 5.114 1.00 8.50 C +ATOM 3682 CE1 PHE C 52 52.007 47.538 3.047 1.00 8.50 C +ATOM 3683 CE2 PHE C 52 52.989 46.238 4.762 1.00 8.50 C +ATOM 3684 CZ PHE C 52 53.121 47.119 3.735 1.00 8.50 C +ATOM 3685 N SER C 53 49.906 42.948 2.821 1.00 19.48 N +ATOM 3686 CA SER C 53 50.643 41.677 2.733 1.00 15.64 C +ATOM 3687 C SER C 53 52.103 41.830 2.265 1.00 11.83 C +ATOM 3688 O SER C 53 52.364 42.068 1.085 1.00 10.95 O +ATOM 3689 CB SER C 53 49.906 40.716 1.795 1.00 17.40 C +ATOM 3690 OG SER C 53 50.436 39.401 1.877 1.00 31.26 O +ATOM 3691 N TYR C 54 53.041 41.665 3.196 1.00 10.97 N +ATOM 3692 CA TYR C 54 54.477 41.773 2.927 1.00 16.30 C +ATOM 3693 C TYR C 54 55.037 40.359 2.944 1.00 23.15 C +ATOM 3694 O TYR C 54 55.147 39.752 4.010 1.00 25.35 O +ATOM 3695 CB TYR C 54 55.137 42.613 4.027 1.00 8.50 C +ATOM 3696 CG TYR C 54 56.592 42.952 3.829 1.00 10.42 C +ATOM 3697 CD1 TYR C 54 57.603 42.077 4.256 1.00 11.60 C +ATOM 3698 CD2 TYR C 54 56.967 44.185 3.305 1.00 14.79 C +ATOM 3699 CE1 TYR C 54 58.954 42.428 4.178 1.00 8.50 C +ATOM 3700 CE2 TYR C 54 58.318 44.546 3.219 1.00 22.73 C +ATOM 3701 CZ TYR C 54 59.299 43.665 3.658 1.00 15.68 C +ATOM 3702 OH TYR C 54 60.611 44.035 3.577 1.00 8.50 O +ATOM 3703 N ALA C 55 55.409 39.846 1.773 1.00 30.76 N +ATOM 3704 CA ALA C 55 55.927 38.482 1.662 1.00 34.28 C +ATOM 3705 C ALA C 55 57.373 38.335 1.172 1.00 35.39 C +ATOM 3706 O ALA C 55 57.847 39.128 0.359 1.00 36.01 O +ATOM 3707 CB ALA C 55 55.007 37.677 0.771 1.00 34.01 C +ATOM 3708 N THR C 56 58.038 37.284 1.646 1.00 37.14 N +ATOM 3709 CA THR C 56 59.411 36.962 1.276 1.00 39.90 C +ATOM 3710 C THR C 56 59.370 35.583 0.613 1.00 45.82 C +ATOM 3711 O THR C 56 58.373 34.849 0.731 1.00 43.48 O +ATOM 3712 CB THR C 56 60.330 36.809 2.509 1.00 36.02 C +ATOM 3713 OG1 THR C 56 60.035 37.817 3.469 1.00 33.68 O +ATOM 3714 CG2 THR C 56 61.799 36.917 2.101 1.00 45.50 C +ATOM 3715 N LYS C 57 60.465 35.225 -0.059 1.00 50.04 N +ATOM 3716 CA LYS C 57 60.566 33.932 -0.717 1.00 49.94 C +ATOM 3717 C LYS C 57 60.501 32.831 0.340 1.00 48.48 C +ATOM 3718 O LYS C 57 59.785 31.847 0.181 1.00 53.40 O +ATOM 3719 CB LYS C 57 61.849 33.863 -1.549 1.00 48.66 C +ATOM 3720 CG LYS C 57 61.705 34.464 -2.966 1.00 43.96 C +ATOM 3721 CD LYS C 57 63.004 34.366 -3.766 1.00 41.53 C +ATOM 3722 CE LYS C 57 62.771 34.604 -5.261 1.00 50.60 C +ATOM 3723 NZ LYS C 57 64.022 34.583 -6.103 1.00 51.18 N +ATOM 3724 N ARG C 58 61.194 33.059 1.451 1.00 46.22 N +ATOM 3725 CA ARG C 58 61.244 32.118 2.573 1.00 44.51 C +ATOM 3726 C ARG C 58 59.974 32.102 3.430 1.00 43.37 C +ATOM 3727 O ARG C 58 59.553 31.046 3.902 1.00 43.83 O +ATOM 3728 CB ARG C 58 62.432 32.440 3.487 1.00 39.10 C +ATOM 3729 CG ARG C 58 63.540 31.383 3.596 1.00 44.88 C +ATOM 3730 CD ARG C 58 63.111 30.105 4.305 1.00 51.82 C +ATOM 3731 NE ARG C 58 63.150 30.169 5.766 1.00 67.67 N +ATOM 3732 CZ ARG C 58 62.332 29.482 6.569 1.00 76.10 C +ATOM 3733 NH1 ARG C 58 61.401 28.676 6.075 1.00 81.31 N +ATOM 3734 NH2 ARG C 58 62.434 29.600 7.884 1.00 95.57 N +ATOM 3735 N GLN C 59 59.379 33.272 3.644 1.00 41.19 N +ATOM 3736 CA GLN C 59 58.182 33.400 4.476 1.00 33.73 C +ATOM 3737 C GLN C 59 57.122 34.224 3.742 1.00 31.09 C +ATOM 3738 O GLN C 59 57.315 35.406 3.512 1.00 35.65 O +ATOM 3739 CB GLN C 59 58.575 34.061 5.816 1.00 22.75 C +ATOM 3740 CG GLN C 59 57.437 34.464 6.718 1.00 18.90 C +ATOM 3741 CD GLN C 59 56.544 33.303 7.106 1.00 24.43 C +ATOM 3742 OE1 GLN C 59 55.618 32.947 6.376 1.00 27.82 O +ATOM 3743 NE2 GLN C 59 56.795 32.729 8.272 1.00 24.99 N +ATOM 3744 N ASP C 60 56.007 33.595 3.386 1.00 28.34 N +ATOM 3745 CA ASP C 60 54.935 34.272 2.667 1.00 27.74 C +ATOM 3746 C ASP C 60 54.200 35.322 3.503 1.00 26.27 C +ATOM 3747 O ASP C 60 53.623 36.277 2.968 1.00 28.59 O +ATOM 3748 CB ASP C 60 53.929 33.263 2.100 1.00 34.20 C +ATOM 3749 CG ASP C 60 53.244 32.435 3.184 1.00 39.34 C +ATOM 3750 OD1 ASP C 60 53.946 31.841 4.031 1.00 44.16 O +ATOM 3751 OD2 ASP C 60 51.995 32.360 3.176 1.00 35.20 O +ATOM 3752 N ASN C 61 54.198 35.149 4.817 1.00 19.68 N +ATOM 3753 CA ASN C 61 53.529 36.110 5.684 1.00 12.10 C +ATOM 3754 C ASN C 61 54.545 36.762 6.603 1.00 13.24 C +ATOM 3755 O ASN C 61 54.482 36.587 7.821 1.00 16.45 O +ATOM 3756 CB ASN C 61 52.434 35.423 6.503 1.00 8.50 C +ATOM 3757 CG ASN C 61 51.285 34.934 5.643 1.00 30.31 C +ATOM 3758 OD1 ASN C 61 51.048 35.473 4.568 1.00 37.44 O +ATOM 3759 ND2 ASN C 61 50.560 33.908 6.113 1.00 37.18 N +ATOM 3760 N GLU C 62 55.492 37.496 6.016 1.00 11.97 N +ATOM 3761 CA GLU C 62 56.547 38.169 6.774 1.00 8.50 C +ATOM 3762 C GLU C 62 55.953 39.233 7.697 1.00 10.99 C +ATOM 3763 O GLU C 62 56.362 39.376 8.841 1.00 18.96 O +ATOM 3764 CB GLU C 62 57.580 38.775 5.830 1.00 8.50 C +ATOM 3765 CG GLU C 62 58.892 39.176 6.497 1.00 14.31 C +ATOM 3766 CD GLU C 62 59.684 37.991 7.032 1.00 21.94 C +ATOM 3767 OE1 GLU C 62 59.119 37.213 7.839 1.00 28.05 O +ATOM 3768 OE2 GLU C 62 60.872 37.840 6.650 1.00 24.46 O +ATOM 3769 N ILE C 63 55.048 40.033 7.168 1.00 12.12 N +ATOM 3770 CA ILE C 63 54.340 41.040 7.940 1.00 9.65 C +ATOM 3771 C ILE C 63 52.995 41.145 7.216 1.00 9.68 C +ATOM 3772 O ILE C 63 52.944 41.327 6.002 1.00 11.03 O +ATOM 3773 CB ILE C 63 55.112 42.414 8.093 1.00 15.83 C +ATOM 3774 CG1 ILE C 63 54.189 43.586 7.822 1.00 17.11 C +ATOM 3775 CG2 ILE C 63 56.372 42.506 7.255 1.00 16.60 C +ATOM 3776 CD1 ILE C 63 53.231 43.835 8.954 1.00 31.22 C +ATOM 3777 N LEU C 64 51.914 40.898 7.944 1.00 9.59 N +ATOM 3778 CA LEU C 64 50.577 40.925 7.374 1.00 10.48 C +ATOM 3779 C LEU C 64 49.523 41.494 8.334 1.00 15.53 C +ATOM 3780 O LEU C 64 49.471 41.119 9.509 1.00 12.78 O +ATOM 3781 CB LEU C 64 50.188 39.513 6.952 1.00 8.50 C +ATOM 3782 CG LEU C 64 48.732 39.222 6.580 1.00 10.28 C +ATOM 3783 CD1 LEU C 64 48.598 38.880 5.120 1.00 9.74 C +ATOM 3784 CD2 LEU C 64 48.249 38.078 7.409 1.00 8.50 C +ATOM 3785 N ILE C 65 48.713 42.423 7.822 1.00 14.80 N +ATOM 3786 CA ILE C 65 47.632 43.053 8.577 1.00 11.27 C +ATOM 3787 C ILE C 65 46.351 42.498 7.962 1.00 12.94 C +ATOM 3788 O ILE C 65 46.104 42.646 6.761 1.00 9.33 O +ATOM 3789 CB ILE C 65 47.668 44.568 8.450 1.00 8.50 C +ATOM 3790 CG1 ILE C 65 48.991 45.091 8.989 1.00 8.50 C +ATOM 3791 CG2 ILE C 65 46.506 45.168 9.179 1.00 8.50 C +ATOM 3792 CD1 ILE C 65 49.256 46.504 8.643 1.00 8.50 C +ATOM 3793 N PHE C 66 45.524 41.889 8.799 1.00 13.99 N +ATOM 3794 CA PHE C 66 44.313 41.241 8.328 1.00 14.61 C +ATOM 3795 C PHE C 66 43.142 41.477 9.282 1.00 14.38 C +ATOM 3796 O PHE C 66 43.342 41.640 10.490 1.00 12.09 O +ATOM 3797 CB PHE C 66 44.627 39.743 8.280 1.00 19.06 C +ATOM 3798 CG PHE C 66 43.602 38.911 7.587 1.00 34.81 C +ATOM 3799 CD1 PHE C 66 42.525 38.363 8.288 1.00 43.96 C +ATOM 3800 CD2 PHE C 66 43.738 38.622 6.238 1.00 40.83 C +ATOM 3801 CE1 PHE C 66 41.596 37.534 7.647 1.00 50.74 C +ATOM 3802 CE2 PHE C 66 42.816 37.795 5.586 1.00 46.15 C +ATOM 3803 CZ PHE C 66 41.743 37.250 6.293 1.00 52.27 C +ATOM 3804 N TRP C 67 41.923 41.486 8.748 1.00 8.64 N +ATOM 3805 CA TRP C 67 40.735 41.621 9.591 1.00 14.20 C +ATOM 3806 C TRP C 67 40.063 40.256 9.609 1.00 22.19 C +ATOM 3807 O TRP C 67 39.582 39.799 8.563 1.00 33.84 O +ATOM 3808 CB TRP C 67 39.747 42.634 9.013 1.00 13.28 C +ATOM 3809 CG TRP C 67 38.379 42.574 9.651 1.00 8.50 C +ATOM 3810 CD1 TRP C 67 37.302 41.870 9.210 1.00 11.52 C +ATOM 3811 CD2 TRP C 67 37.969 43.211 10.867 1.00 10.39 C +ATOM 3812 NE1 TRP C 67 36.246 42.014 10.077 1.00 9.19 N +ATOM 3813 CE2 TRP C 67 36.629 42.831 11.105 1.00 12.24 C +ATOM 3814 CE3 TRP C 67 38.603 44.066 11.780 1.00 8.50 C +ATOM 3815 CZ2 TRP C 67 35.916 43.271 12.218 1.00 12.57 C +ATOM 3816 CZ3 TRP C 67 37.901 44.501 12.877 1.00 8.50 C +ATOM 3817 CH2 TRP C 67 36.565 44.101 13.093 1.00 14.96 C +ATOM 3818 N SER C 68 40.063 39.577 10.753 1.00 20.69 N +ATOM 3819 CA SER C 68 39.414 38.265 10.829 1.00 20.68 C +ATOM 3820 C SER C 68 38.003 38.400 11.407 1.00 17.45 C +ATOM 3821 O SER C 68 37.806 38.809 12.551 1.00 15.16 O +ATOM 3822 CB SER C 68 40.267 37.234 11.595 1.00 20.99 C +ATOM 3823 OG SER C 68 40.376 37.534 12.970 1.00 26.67 O +ATOM 3824 N LYS C 69 37.028 38.120 10.556 1.00 20.13 N +ATOM 3825 CA LYS C 69 35.608 38.207 10.867 1.00 21.12 C +ATOM 3826 C LYS C 69 35.298 37.798 12.287 1.00 21.35 C +ATOM 3827 O LYS C 69 35.822 36.813 12.770 1.00 26.27 O +ATOM 3828 CB LYS C 69 34.834 37.324 9.892 1.00 13.93 C +ATOM 3829 CG LYS C 69 33.401 37.696 9.618 1.00 18.06 C +ATOM 3830 CD LYS C 69 32.478 37.261 10.722 1.00 34.99 C +ATOM 3831 CE LYS C 69 31.029 37.142 10.248 1.00 44.69 C +ATOM 3832 NZ LYS C 69 30.819 35.916 9.418 1.00 58.12 N +ATOM 3833 N ASP C 70 34.485 38.600 12.964 1.00 30.69 N +ATOM 3834 CA ASP C 70 34.067 38.334 14.338 1.00 39.24 C +ATOM 3835 C ASP C 70 35.139 38.419 15.430 1.00 41.57 C +ATOM 3836 O ASP C 70 34.861 38.146 16.598 1.00 49.22 O +ATOM 3837 CB ASP C 70 33.369 36.966 14.428 1.00 47.64 C +ATOM 3838 CG ASP C 70 31.928 36.997 13.935 1.00 59.79 C +ATOM 3839 OD1 ASP C 70 31.353 38.100 13.769 1.00 68.72 O +ATOM 3840 OD2 ASP C 70 31.367 35.899 13.717 1.00 64.54 O +ATOM 3841 N ILE C 71 36.358 38.784 15.075 1.00 38.40 N +ATOM 3842 CA ILE C 71 37.397 38.868 16.086 1.00 33.11 C +ATOM 3843 C ILE C 71 38.007 40.266 16.181 1.00 28.23 C +ATOM 3844 O ILE C 71 37.881 40.937 17.211 1.00 30.46 O +ATOM 3845 CB ILE C 71 38.511 37.813 15.840 1.00 35.94 C +ATOM 3846 CG1 ILE C 71 37.939 36.396 15.942 1.00 38.43 C +ATOM 3847 CG2 ILE C 71 39.637 37.985 16.843 1.00 32.32 C +ATOM 3848 CD1 ILE C 71 38.977 35.282 15.708 1.00 48.85 C +ATOM 3849 N GLY C 72 38.667 40.696 15.114 1.00 17.35 N +ATOM 3850 CA GLY C 72 39.306 41.992 15.117 1.00 13.80 C +ATOM 3851 C GLY C 72 40.517 42.024 14.207 1.00 13.18 C +ATOM 3852 O GLY C 72 40.595 41.301 13.208 1.00 14.18 O +ATOM 3853 N TYR C 73 41.455 42.899 14.518 1.00 8.50 N +ATOM 3854 CA TYR C 73 42.642 43.026 13.712 1.00 8.50 C +ATOM 3855 C TYR C 73 43.613 41.940 14.048 1.00 10.69 C +ATOM 3856 O TYR C 73 43.886 41.683 15.217 1.00 10.05 O +ATOM 3857 CB TYR C 73 43.281 44.389 13.906 1.00 8.50 C +ATOM 3858 CG TYR C 73 42.435 45.496 13.343 1.00 11.54 C +ATOM 3859 CD1 TYR C 73 42.365 45.711 11.968 1.00 12.23 C +ATOM 3860 CD2 TYR C 73 41.661 46.292 14.174 1.00 8.50 C +ATOM 3861 CE1 TYR C 73 41.539 46.684 11.441 1.00 11.12 C +ATOM 3862 CE2 TYR C 73 40.835 47.262 13.660 1.00 8.50 C +ATOM 3863 CZ TYR C 73 40.775 47.452 12.297 1.00 13.91 C +ATOM 3864 OH TYR C 73 39.939 48.417 11.778 1.00 32.13 O +ATOM 3865 N SER C 74 44.136 41.309 13.002 1.00 12.87 N +ATOM 3866 CA SER C 74 45.093 40.224 13.130 1.00 13.00 C +ATOM 3867 C SER C 74 46.422 40.700 12.584 1.00 12.31 C +ATOM 3868 O SER C 74 46.593 40.823 11.367 1.00 17.33 O +ATOM 3869 CB SER C 74 44.600 39.010 12.345 1.00 13.63 C +ATOM 3870 OG SER C 74 45.593 38.003 12.277 1.00 24.13 O +ATOM 3871 N PHE C 75 47.342 41.018 13.481 1.00 8.50 N +ATOM 3872 CA PHE C 75 48.648 41.490 13.071 1.00 10.98 C +ATOM 3873 C PHE C 75 49.646 40.344 13.179 1.00 11.87 C +ATOM 3874 O PHE C 75 49.899 39.849 14.268 1.00 12.35 O +ATOM 3875 CB PHE C 75 49.090 42.672 13.949 1.00 13.05 C +ATOM 3876 CG PHE C 75 50.450 43.203 13.605 1.00 13.11 C +ATOM 3877 CD1 PHE C 75 50.681 43.821 12.369 1.00 13.24 C +ATOM 3878 CD2 PHE C 75 51.507 43.053 14.491 1.00 8.50 C +ATOM 3879 CE1 PHE C 75 51.951 44.278 12.026 1.00 15.58 C +ATOM 3880 CE2 PHE C 75 52.787 43.510 14.155 1.00 18.69 C +ATOM 3881 CZ PHE C 75 53.012 44.123 12.918 1.00 19.90 C +ATOM 3882 N THR C 76 50.232 39.944 12.056 1.00 16.52 N +ATOM 3883 CA THR C 76 51.203 38.849 12.051 1.00 15.50 C +ATOM 3884 C THR C 76 52.540 39.224 11.411 1.00 12.45 C +ATOM 3885 O THR C 76 52.595 39.808 10.328 1.00 16.59 O +ATOM 3886 CB THR C 76 50.591 37.554 11.402 1.00 19.54 C +ATOM 3887 OG1 THR C 76 51.571 36.880 10.597 1.00 12.59 O +ATOM 3888 CG2 THR C 76 49.345 37.891 10.566 1.00 21.64 C +ATOM 3889 N VAL C 77 53.617 38.964 12.128 1.00 10.16 N +ATOM 3890 CA VAL C 77 54.956 39.243 11.616 1.00 19.52 C +ATOM 3891 C VAL C 77 55.817 37.981 11.792 1.00 24.79 C +ATOM 3892 O VAL C 77 55.868 37.392 12.879 1.00 27.84 O +ATOM 3893 CB VAL C 77 55.620 40.495 12.290 1.00 17.94 C +ATOM 3894 CG1 VAL C 77 55.190 40.619 13.735 1.00 16.50 C +ATOM 3895 CG2 VAL C 77 57.162 40.413 12.197 1.00 8.50 C +ATOM 3896 N GLY C 78 56.408 37.520 10.693 1.00 22.00 N +ATOM 3897 CA GLY C 78 57.243 36.341 10.732 1.00 17.57 C +ATOM 3898 C GLY C 78 56.423 35.079 10.914 1.00 21.97 C +ATOM 3899 O GLY C 78 56.853 34.156 11.600 1.00 34.09 O +ATOM 3900 N GLY C 79 55.240 35.029 10.310 1.00 18.77 N +ATOM 3901 CA GLY C 79 54.401 33.852 10.418 1.00 14.91 C +ATOM 3902 C GLY C 79 53.674 33.713 11.737 1.00 17.14 C +ATOM 3903 O GLY C 79 52.787 32.890 11.831 1.00 15.71 O +ATOM 3904 N SER C 80 54.053 34.493 12.746 1.00 19.48 N +ATOM 3905 CA SER C 80 53.409 34.452 14.054 1.00 22.52 C +ATOM 3906 C SER C 80 52.359 35.556 14.195 1.00 21.46 C +ATOM 3907 O SER C 80 52.646 36.732 14.000 1.00 29.01 O +ATOM 3908 CB SER C 80 54.458 34.525 15.175 1.00 31.25 C +ATOM 3909 OG SER C 80 55.281 33.347 15.186 1.00 41.98 O +ATOM 3910 N GLU C 81 51.139 35.148 14.519 1.00 17.28 N +ATOM 3911 CA GLU C 81 49.985 36.030 14.662 1.00 13.89 C +ATOM 3912 C GLU C 81 49.744 36.552 16.084 1.00 15.37 C +ATOM 3913 O GLU C 81 50.198 35.975 17.071 1.00 18.03 O +ATOM 3914 CB GLU C 81 48.752 35.272 14.187 1.00 8.78 C +ATOM 3915 CG GLU C 81 47.441 35.996 14.221 1.00 18.39 C +ATOM 3916 CD GLU C 81 46.258 35.060 14.033 1.00 28.09 C +ATOM 3917 OE1 GLU C 81 46.105 34.123 14.838 1.00 42.39 O +ATOM 3918 OE2 GLU C 81 45.458 35.276 13.103 1.00 35.05 O +ATOM 3919 N ILE C 82 49.007 37.654 16.161 1.00 18.66 N +ATOM 3920 CA ILE C 82 48.642 38.305 17.412 1.00 11.72 C +ATOM 3921 C ILE C 82 47.310 39.010 17.139 1.00 8.75 C +ATOM 3922 O ILE C 82 47.044 39.447 16.012 1.00 8.50 O +ATOM 3923 CB ILE C 82 49.742 39.287 17.864 1.00 9.48 C +ATOM 3924 CG1 ILE C 82 49.682 39.448 19.372 1.00 22.04 C +ATOM 3925 CG2 ILE C 82 49.592 40.644 17.216 1.00 8.50 C +ATOM 3926 CD1 ILE C 82 50.930 40.108 19.933 1.00 36.77 C +ATOM 3927 N LEU C 83 46.466 39.121 18.148 1.00 8.50 N +ATOM 3928 CA LEU C 83 45.165 39.717 17.916 1.00 8.58 C +ATOM 3929 C LEU C 83 44.826 40.976 18.675 1.00 15.44 C +ATOM 3930 O LEU C 83 45.177 41.133 19.839 1.00 21.41 O +ATOM 3931 CB LEU C 83 44.076 38.685 18.176 1.00 9.60 C +ATOM 3932 CG LEU C 83 43.470 37.892 17.012 1.00 13.99 C +ATOM 3933 CD1 LEU C 83 44.529 37.392 16.077 1.00 22.32 C +ATOM 3934 CD2 LEU C 83 42.673 36.725 17.567 1.00 23.36 C +ATOM 3935 N PHE C 84 44.101 41.861 18.003 1.00 17.84 N +ATOM 3936 CA PHE C 84 43.630 43.106 18.587 1.00 9.85 C +ATOM 3937 C PHE C 84 42.142 43.073 18.385 1.00 13.68 C +ATOM 3938 O PHE C 84 41.620 43.323 17.291 1.00 17.03 O +ATOM 3939 CB PHE C 84 44.279 44.263 17.895 1.00 8.50 C +ATOM 3940 CG PHE C 84 45.703 44.412 18.263 1.00 8.50 C +ATOM 3941 CD1 PHE C 84 46.047 44.691 19.583 1.00 16.78 C +ATOM 3942 CD2 PHE C 84 46.706 44.237 17.326 1.00 11.51 C +ATOM 3943 CE1 PHE C 84 47.369 44.793 19.973 1.00 8.60 C +ATOM 3944 CE2 PHE C 84 48.036 44.336 17.699 1.00 20.38 C +ATOM 3945 CZ PHE C 84 48.369 44.615 19.034 1.00 17.65 C +ATOM 3946 N GLU C 85 41.481 42.600 19.425 1.00 15.26 N +ATOM 3947 CA GLU C 85 40.041 42.422 19.406 1.00 23.47 C +ATOM 3948 C GLU C 85 39.247 43.698 19.253 1.00 23.60 C +ATOM 3949 O GLU C 85 39.537 44.714 19.889 1.00 28.15 O +ATOM 3950 CB GLU C 85 39.602 41.668 20.655 1.00 37.22 C +ATOM 3951 CG GLU C 85 40.446 40.420 20.920 1.00 62.93 C +ATOM 3952 CD GLU C 85 39.690 39.332 21.682 1.00 78.40 C +ATOM 3953 OE1 GLU C 85 39.670 39.382 22.935 1.00 89.07 O +ATOM 3954 OE2 GLU C 85 39.118 38.422 21.031 1.00 81.25 O +ATOM 3955 N VAL C 86 38.259 43.639 18.373 1.00 26.40 N +ATOM 3956 CA VAL C 86 37.372 44.760 18.097 1.00 35.15 C +ATOM 3957 C VAL C 86 35.958 44.188 18.046 1.00 43.41 C +ATOM 3958 O VAL C 86 35.528 43.640 17.029 1.00 48.66 O +ATOM 3959 CB VAL C 86 37.716 45.433 16.758 1.00 37.79 C +ATOM 3960 CG1 VAL C 86 36.668 46.473 16.411 1.00 45.32 C +ATOM 3961 CG2 VAL C 86 39.091 46.099 16.836 1.00 44.18 C +ATOM 3962 N PRO C 87 35.220 44.306 19.158 1.00 51.55 N +ATOM 3963 CA PRO C 87 33.847 43.816 19.321 1.00 62.01 C +ATOM 3964 C PRO C 87 32.779 44.457 18.427 1.00 71.41 C +ATOM 3965 O PRO C 87 32.150 43.778 17.609 1.00 78.70 O +ATOM 3966 CB PRO C 87 33.575 44.067 20.808 1.00 59.69 C +ATOM 3967 CG PRO C 87 34.357 45.309 21.084 1.00 57.20 C +ATOM 3968 CD PRO C 87 35.663 45.020 20.371 1.00 55.43 C +ATOM 3969 N GLU C 88 32.547 45.752 18.622 1.00 75.25 N +ATOM 3970 CA GLU C 88 31.557 46.491 17.855 1.00 75.57 C +ATOM 3971 C GLU C 88 32.233 47.045 16.601 1.00 71.84 C +ATOM 3972 O GLU C 88 33.076 47.950 16.683 1.00 68.57 O +ATOM 3973 CB GLU C 88 30.995 47.634 18.710 1.00 85.18 C +ATOM 3974 CG GLU C 88 29.726 48.288 18.159 1.00 98.59 C +ATOM 3975 CD GLU C 88 29.344 49.564 18.900 1.00104.21 C +ATOM 3976 OE1 GLU C 88 29.453 49.590 20.148 1.00105.50 O +ATOM 3977 OE2 GLU C 88 28.936 50.543 18.228 1.00109.18 O +ATOM 3978 N VAL C 89 31.907 46.466 15.449 1.00 69.04 N +ATOM 3979 CA VAL C 89 32.487 46.921 14.197 1.00 67.11 C +ATOM 3980 C VAL C 89 31.608 48.015 13.598 1.00 65.86 C +ATOM 3981 O VAL C 89 30.372 47.905 13.593 1.00 64.47 O +ATOM 3982 CB VAL C 89 32.679 45.756 13.191 1.00 65.69 C +ATOM 3983 CG1 VAL C 89 31.327 45.218 12.698 1.00 62.38 C +ATOM 3984 CG2 VAL C 89 33.557 46.218 12.043 1.00 71.65 C +ATOM 3985 N THR C 90 32.244 49.088 13.142 1.00 64.41 N +ATOM 3986 CA THR C 90 31.519 50.196 12.541 1.00 62.59 C +ATOM 3987 C THR C 90 31.981 50.384 11.092 1.00 55.81 C +ATOM 3988 O THR C 90 33.133 50.085 10.743 1.00 57.55 O +ATOM 3989 CB THR C 90 31.702 51.509 13.361 1.00 66.51 C +ATOM 3990 OG1 THR C 90 30.779 52.506 12.896 1.00 64.64 O +ATOM 3991 CG2 THR C 90 33.143 52.032 13.242 1.00 70.12 C +ATOM 3992 N VAL C 91 31.065 50.851 10.253 1.00 45.71 N +ATOM 3993 CA VAL C 91 31.358 51.084 8.851 1.00 38.53 C +ATOM 3994 C VAL C 91 31.672 52.565 8.622 1.00 30.90 C +ATOM 3995 O VAL C 91 30.805 53.419 8.753 1.00 37.86 O +ATOM 3996 CB VAL C 91 30.185 50.608 7.978 1.00 36.47 C +ATOM 3997 CG1 VAL C 91 28.883 51.287 8.418 1.00 41.58 C +ATOM 3998 CG2 VAL C 91 30.484 50.847 6.510 1.00 43.46 C +ATOM 3999 N ALA C 92 32.938 52.851 8.350 1.00 17.24 N +ATOM 4000 CA ALA C 92 33.436 54.201 8.113 1.00 11.38 C +ATOM 4001 C ALA C 92 34.898 54.060 7.738 1.00 10.30 C +ATOM 4002 O ALA C 92 35.498 53.022 8.013 1.00 17.93 O +ATOM 4003 CB ALA C 92 33.322 55.018 9.350 1.00 17.36 C +ATOM 4004 N PRO C 93 35.477 55.056 7.038 1.00 8.50 N +ATOM 4005 CA PRO C 93 36.882 54.852 6.716 1.00 9.27 C +ATOM 4006 C PRO C 93 37.622 54.718 8.033 1.00 10.00 C +ATOM 4007 O PRO C 93 37.201 55.284 9.042 1.00 19.09 O +ATOM 4008 CB PRO C 93 37.248 56.140 5.980 1.00 8.50 C +ATOM 4009 CG PRO C 93 36.000 56.494 5.313 1.00 8.50 C +ATOM 4010 CD PRO C 93 34.986 56.287 6.403 1.00 8.50 C +ATOM 4011 N VAL C 94 38.680 53.925 8.040 1.00 8.50 N +ATOM 4012 CA VAL C 94 39.461 53.738 9.243 1.00 9.43 C +ATOM 4013 C VAL C 94 40.947 53.895 8.911 1.00 9.19 C +ATOM 4014 O VAL C 94 41.369 53.617 7.794 1.00 11.21 O +ATOM 4015 CB VAL C 94 39.102 52.404 9.917 1.00 8.50 C +ATOM 4016 CG1 VAL C 94 38.875 51.363 8.879 1.00 29.09 C +ATOM 4017 CG2 VAL C 94 40.175 51.967 10.860 1.00 8.50 C +ATOM 4018 N HIS C 95 41.701 54.471 9.838 1.00 8.50 N +ATOM 4019 CA HIS C 95 43.116 54.704 9.642 1.00 8.50 C +ATOM 4020 C HIS C 95 43.859 53.931 10.693 1.00 8.91 C +ATOM 4021 O HIS C 95 43.549 54.047 11.866 1.00 15.34 O +ATOM 4022 CB HIS C 95 43.413 56.193 9.794 1.00 8.50 C +ATOM 4023 CG HIS C 95 44.873 56.533 9.871 1.00 8.50 C +ATOM 4024 ND1 HIS C 95 45.638 56.806 8.756 1.00 8.50 N +ATOM 4025 CD2 HIS C 95 45.701 56.670 10.936 1.00 8.50 C +ATOM 4026 CE1 HIS C 95 46.873 57.094 9.128 1.00 8.50 C +ATOM 4027 NE2 HIS C 95 46.936 57.018 10.446 1.00 10.39 N +ATOM 4028 N ILE C 96 44.835 53.134 10.281 1.00 10.38 N +ATOM 4029 CA ILE C 96 45.625 52.359 11.233 1.00 9.55 C +ATOM 4030 C ILE C 96 47.122 52.556 11.040 1.00 8.50 C +ATOM 4031 O ILE C 96 47.582 52.859 9.938 1.00 8.50 O +ATOM 4032 CB ILE C 96 45.325 50.839 11.147 1.00 12.50 C +ATOM 4033 CG1 ILE C 96 45.627 50.310 9.753 1.00 8.50 C +ATOM 4034 CG2 ILE C 96 43.863 50.560 11.509 1.00 15.85 C +ATOM 4035 CD1 ILE C 96 45.611 48.840 9.687 1.00 13.24 C +ATOM 4036 N CYS C 97 47.852 52.492 12.144 1.00 8.50 N +ATOM 4037 CA CYS C 97 49.302 52.588 12.134 1.00 9.50 C +ATOM 4038 C CYS C 97 49.687 51.460 13.049 1.00 8.50 C +ATOM 4039 O CYS C 97 49.095 51.309 14.106 1.00 8.50 O +ATOM 4040 CB CYS C 97 49.836 53.877 12.758 1.00 16.52 C +ATOM 4041 SG CYS C 97 49.974 55.363 11.714 1.00 11.08 S +ATOM 4042 N THR C 98 50.660 50.663 12.632 1.00 9.56 N +ATOM 4043 CA THR C 98 51.123 49.541 13.430 1.00 11.14 C +ATOM 4044 C THR C 98 52.643 49.489 13.362 1.00 8.50 C +ATOM 4045 O THR C 98 53.233 49.833 12.340 1.00 8.50 O +ATOM 4046 CB THR C 98 50.483 48.219 12.959 1.00 14.84 C +ATOM 4047 OG1 THR C 98 50.898 47.147 13.813 1.00 24.30 O +ATOM 4048 CG2 THR C 98 50.869 47.909 11.536 1.00 12.89 C +ATOM 4049 N SER C 99 53.271 49.123 14.472 1.00 8.50 N +ATOM 4050 CA SER C 99 54.727 49.070 14.544 1.00 14.76 C +ATOM 4051 C SER C 99 55.276 47.885 15.337 1.00 16.08 C +ATOM 4052 O SER C 99 54.621 47.388 16.247 1.00 20.73 O +ATOM 4053 CB SER C 99 55.303 50.396 15.100 1.00 19.14 C +ATOM 4054 OG SER C 99 54.744 50.798 16.343 1.00 8.50 O +ATOM 4055 N TRP C 100 56.489 47.453 14.994 1.00 15.04 N +ATOM 4056 CA TRP C 100 57.141 46.329 15.652 1.00 9.78 C +ATOM 4057 C TRP C 100 58.617 46.628 15.828 1.00 11.10 C +ATOM 4058 O TRP C 100 59.231 47.282 14.990 1.00 16.84 O +ATOM 4059 CB TRP C 100 56.941 45.062 14.814 1.00 21.28 C +ATOM 4060 CG TRP C 100 57.822 43.901 15.182 1.00 18.32 C +ATOM 4061 CD1 TRP C 100 57.618 42.995 16.189 1.00 14.96 C +ATOM 4062 CD2 TRP C 100 59.050 43.530 14.546 1.00 15.42 C +ATOM 4063 NE1 TRP C 100 58.648 42.092 16.221 1.00 11.00 N +ATOM 4064 CE2 TRP C 100 59.540 42.393 15.225 1.00 13.00 C +ATOM 4065 CE3 TRP C 100 59.786 44.050 13.462 1.00 12.27 C +ATOM 4066 CZ2 TRP C 100 60.734 41.761 14.858 1.00 18.67 C +ATOM 4067 CZ3 TRP C 100 60.974 43.422 13.095 1.00 13.25 C +ATOM 4068 CH2 TRP C 100 61.434 42.288 13.793 1.00 18.43 C +ATOM 4069 N GLU C 101 59.191 46.130 16.914 1.00 14.57 N +ATOM 4070 CA GLU C 101 60.602 46.346 17.234 1.00 17.10 C +ATOM 4071 C GLU C 101 61.241 45.020 17.615 1.00 19.10 C +ATOM 4072 O GLU C 101 60.855 44.423 18.626 1.00 22.30 O +ATOM 4073 CB GLU C 101 60.708 47.323 18.414 1.00 16.48 C +ATOM 4074 CG GLU C 101 62.118 47.572 18.938 1.00 25.32 C +ATOM 4075 CD GLU C 101 62.147 48.504 20.143 1.00 25.13 C +ATOM 4076 OE1 GLU C 101 61.780 48.046 21.243 1.00 30.55 O +ATOM 4077 OE2 GLU C 101 62.541 49.681 19.999 1.00 17.96 O +ATOM 4078 N SER C 102 62.230 44.577 16.838 1.00 19.29 N +ATOM 4079 CA SER C 102 62.917 43.310 17.129 1.00 21.07 C +ATOM 4080 C SER C 102 63.497 43.266 18.557 1.00 21.92 C +ATOM 4081 O SER C 102 63.258 42.312 19.315 1.00 22.74 O +ATOM 4082 CB SER C 102 64.041 43.051 16.109 1.00 21.60 C +ATOM 4083 OG SER C 102 64.867 41.965 16.509 1.00 12.92 O +ATOM 4084 N ALA C 103 64.190 44.339 18.935 1.00 17.76 N +ATOM 4085 CA ALA C 103 64.818 44.433 20.235 1.00 14.27 C +ATOM 4086 C ALA C 103 63.972 44.083 21.470 1.00 17.82 C +ATOM 4087 O ALA C 103 64.532 43.637 22.481 1.00 28.05 O +ATOM 4088 CB ALA C 103 65.436 45.804 20.392 1.00 20.49 C +ATOM 4089 N SER C 104 62.650 44.265 21.412 1.00 13.19 N +ATOM 4090 CA SER C 104 61.809 43.975 22.575 1.00 11.38 C +ATOM 4091 C SER C 104 60.579 43.142 22.235 1.00 11.43 C +ATOM 4092 O SER C 104 59.939 42.546 23.112 1.00 8.76 O +ATOM 4093 CB SER C 104 61.363 45.287 23.203 1.00 8.50 C +ATOM 4094 OG SER C 104 60.509 45.967 22.299 1.00 12.04 O +ATOM 4095 N GLY C 105 60.230 43.140 20.959 1.00 12.65 N +ATOM 4096 CA GLY C 105 59.072 42.399 20.511 1.00 12.56 C +ATOM 4097 C GLY C 105 57.810 43.201 20.708 1.00 14.24 C +ATOM 4098 O GLY C 105 56.723 42.723 20.420 1.00 19.03 O +ATOM 4099 N ILE C 106 57.943 44.433 21.182 1.00 13.96 N +ATOM 4100 CA ILE C 106 56.769 45.257 21.403 1.00 10.36 C +ATOM 4101 C ILE C 106 56.145 45.736 20.117 1.00 8.50 C +ATOM 4102 O ILE C 106 56.790 46.373 19.297 1.00 11.29 O +ATOM 4103 CB ILE C 106 57.078 46.468 22.286 1.00 13.78 C +ATOM 4104 CG1 ILE C 106 57.459 45.998 23.687 1.00 17.34 C +ATOM 4105 CG2 ILE C 106 55.852 47.349 22.406 1.00 21.42 C +ATOM 4106 CD1 ILE C 106 57.736 47.133 24.651 1.00 23.26 C +ATOM 4107 N VAL C 107 54.876 45.412 19.955 1.00 8.50 N +ATOM 4108 CA VAL C 107 54.112 45.824 18.796 1.00 10.37 C +ATOM 4109 C VAL C 107 52.955 46.714 19.285 1.00 10.02 C +ATOM 4110 O VAL C 107 52.316 46.403 20.287 1.00 11.24 O +ATOM 4111 CB VAL C 107 53.592 44.597 17.991 1.00 11.93 C +ATOM 4112 CG1 VAL C 107 53.110 43.511 18.910 1.00 9.88 C +ATOM 4113 CG2 VAL C 107 52.454 45.009 17.089 1.00 21.09 C +ATOM 4114 N GLU C 108 52.777 47.868 18.641 1.00 13.23 N +ATOM 4115 CA GLU C 108 51.714 48.830 18.965 1.00 8.50 C +ATOM 4116 C GLU C 108 50.729 48.796 17.803 1.00 10.27 C +ATOM 4117 O GLU C 108 51.112 48.553 16.660 1.00 11.58 O +ATOM 4118 CB GLU C 108 52.257 50.269 19.034 1.00 8.50 C +ATOM 4119 CG GLU C 108 53.312 50.590 20.095 1.00 8.50 C +ATOM 4120 CD GLU C 108 53.965 51.970 19.890 1.00 21.61 C +ATOM 4121 OE1 GLU C 108 53.682 52.663 18.878 1.00 15.84 O +ATOM 4122 OE2 GLU C 108 54.795 52.362 20.739 1.00 31.25 O +ATOM 4123 N PHE C 109 49.465 49.046 18.083 1.00 11.83 N +ATOM 4124 CA PHE C 109 48.459 49.080 17.030 1.00 9.52 C +ATOM 4125 C PHE C 109 47.634 50.312 17.369 1.00 10.38 C +ATOM 4126 O PHE C 109 47.131 50.433 18.484 1.00 11.81 O +ATOM 4127 CB PHE C 109 47.590 47.818 17.068 1.00 9.68 C +ATOM 4128 CG PHE C 109 46.947 47.474 15.750 1.00 14.97 C +ATOM 4129 CD1 PHE C 109 47.641 46.712 14.801 1.00 15.01 C +ATOM 4130 CD2 PHE C 109 45.659 47.909 15.447 1.00 8.50 C +ATOM 4131 CE1 PHE C 109 47.064 46.391 13.574 1.00 8.50 C +ATOM 4132 CE2 PHE C 109 45.076 47.592 14.223 1.00 8.50 C +ATOM 4133 CZ PHE C 109 45.782 46.832 13.288 1.00 8.50 C +ATOM 4134 N TRP C 110 47.606 51.278 16.460 1.00 13.05 N +ATOM 4135 CA TRP C 110 46.852 52.515 16.664 1.00 10.99 C +ATOM 4136 C TRP C 110 45.709 52.551 15.683 1.00 8.50 C +ATOM 4137 O TRP C 110 45.932 52.507 14.480 1.00 11.67 O +ATOM 4138 CB TRP C 110 47.725 53.746 16.400 1.00 13.54 C +ATOM 4139 CG TRP C 110 48.884 53.890 17.274 1.00 8.50 C +ATOM 4140 CD1 TRP C 110 49.989 53.104 17.298 1.00 8.50 C +ATOM 4141 CD2 TRP C 110 49.063 54.880 18.273 1.00 8.50 C +ATOM 4142 NE1 TRP C 110 50.854 53.542 18.265 1.00 18.88 N +ATOM 4143 CE2 TRP C 110 50.312 54.635 18.884 1.00 14.90 C +ATOM 4144 CE3 TRP C 110 48.290 55.952 18.722 1.00 13.05 C +ATOM 4145 CZ2 TRP C 110 50.811 55.427 19.930 1.00 14.06 C +ATOM 4146 CZ3 TRP C 110 48.788 56.745 19.770 1.00 19.53 C +ATOM 4147 CH2 TRP C 110 50.035 56.474 20.358 1.00 12.92 C +ATOM 4148 N VAL C 111 44.495 52.641 16.187 1.00 8.50 N +ATOM 4149 CA VAL C 111 43.342 52.708 15.314 1.00 10.02 C +ATOM 4150 C VAL C 111 42.733 54.100 15.468 1.00 13.94 C +ATOM 4151 O VAL C 111 42.376 54.511 16.569 1.00 18.23 O +ATOM 4152 CB VAL C 111 42.296 51.629 15.656 1.00 8.50 C +ATOM 4153 CG1 VAL C 111 41.123 51.710 14.721 1.00 8.50 C +ATOM 4154 CG2 VAL C 111 42.916 50.276 15.561 1.00 13.01 C +ATOM 4155 N ASP C 112 42.654 54.830 14.362 1.00 11.42 N +ATOM 4156 CA ASP C 112 42.108 56.173 14.332 1.00 8.50 C +ATOM 4157 C ASP C 112 42.767 57.139 15.306 1.00 8.50 C +ATOM 4158 O ASP C 112 42.095 57.936 15.952 1.00 13.38 O +ATOM 4159 CB ASP C 112 40.597 56.146 14.533 1.00 8.50 C +ATOM 4160 CG ASP C 112 39.838 55.860 13.251 1.00 8.50 C +ATOM 4161 OD1 ASP C 112 40.336 56.214 12.163 1.00 9.33 O +ATOM 4162 OD2 ASP C 112 38.718 55.310 13.334 1.00 8.50 O +ATOM 4163 N GLY C 113 44.088 57.068 15.407 1.00 9.04 N +ATOM 4164 CA GLY C 113 44.810 57.978 16.281 1.00 9.15 C +ATOM 4165 C GLY C 113 44.867 57.596 17.747 1.00 15.39 C +ATOM 4166 O GLY C 113 45.586 58.239 18.526 1.00 18.14 O +ATOM 4167 N LYS C 114 44.095 56.578 18.137 1.00 13.30 N +ATOM 4168 CA LYS C 114 44.073 56.102 19.519 1.00 8.65 C +ATOM 4169 C LYS C 114 44.760 54.733 19.623 1.00 9.50 C +ATOM 4170 O LYS C 114 44.460 53.806 18.867 1.00 15.20 O +ATOM 4171 CB LYS C 114 42.643 56.090 20.056 1.00 8.50 C +ATOM 4172 CG LYS C 114 42.173 57.490 20.418 1.00 23.64 C +ATOM 4173 CD LYS C 114 40.839 57.533 21.168 1.00 37.49 C +ATOM 4174 CE LYS C 114 40.676 58.913 21.831 1.00 40.55 C +ATOM 4175 NZ LYS C 114 39.359 59.162 22.492 1.00 47.79 N +ATOM 4176 N PRO C 115 45.714 54.601 20.544 1.00 8.50 N +ATOM 4177 CA PRO C 115 46.482 53.392 20.775 1.00 8.87 C +ATOM 4178 C PRO C 115 45.793 52.261 21.520 1.00 10.48 C +ATOM 4179 O PRO C 115 45.038 52.485 22.468 1.00 12.62 O +ATOM 4180 CB PRO C 115 47.651 53.916 21.596 1.00 8.50 C +ATOM 4181 CG PRO C 115 46.984 54.854 22.489 1.00 8.50 C +ATOM 4182 CD PRO C 115 46.062 55.611 21.556 1.00 15.39 C +ATOM 4183 N ARG C 116 46.082 51.047 21.077 1.00 8.50 N +ATOM 4184 CA ARG C 116 45.594 49.841 21.720 1.00 10.73 C +ATOM 4185 C ARG C 116 46.780 49.518 22.635 1.00 13.67 C +ATOM 4186 O ARG C 116 47.857 50.107 22.476 1.00 16.85 O +ATOM 4187 CB ARG C 116 45.404 48.717 20.702 1.00 8.50 C +ATOM 4188 CG ARG C 116 44.487 49.066 19.576 1.00 13.04 C +ATOM 4189 CD ARG C 116 43.037 49.068 20.000 1.00 35.56 C +ATOM 4190 NE ARG C 116 42.507 47.715 20.115 1.00 32.76 N +ATOM 4191 CZ ARG C 116 42.379 47.063 21.260 1.00 39.18 C +ATOM 4192 NH1 ARG C 116 42.742 47.640 22.400 1.00 43.56 N +ATOM 4193 NH2 ARG C 116 41.893 45.832 21.264 1.00 43.55 N +ATOM 4194 N VAL C 117 46.616 48.587 23.570 1.00 14.13 N +ATOM 4195 CA VAL C 117 47.715 48.256 24.474 1.00 10.87 C +ATOM 4196 C VAL C 117 48.908 47.669 23.718 1.00 16.51 C +ATOM 4197 O VAL C 117 48.774 47.233 22.570 1.00 18.93 O +ATOM 4198 CB VAL C 117 47.295 47.273 25.562 1.00 11.74 C +ATOM 4199 CG1 VAL C 117 48.221 47.437 26.753 1.00 11.53 C +ATOM 4200 CG2 VAL C 117 45.834 47.479 25.962 1.00 14.67 C +ATOM 4201 N ARG C 118 50.080 47.696 24.347 1.00 16.56 N +ATOM 4202 CA ARG C 118 51.286 47.158 23.724 1.00 11.01 C +ATOM 4203 C ARG C 118 51.379 45.668 23.980 1.00 12.64 C +ATOM 4204 O ARG C 118 51.126 45.205 25.097 1.00 18.50 O +ATOM 4205 CB ARG C 118 52.530 47.826 24.279 1.00 8.50 C +ATOM 4206 CG ARG C 118 52.552 49.320 24.123 1.00 8.50 C +ATOM 4207 CD ARG C 118 53.950 49.824 24.381 1.00 19.09 C +ATOM 4208 NE ARG C 118 53.970 51.115 25.061 1.00 17.28 N +ATOM 4209 CZ ARG C 118 54.365 52.237 24.492 1.00 12.01 C +ATOM 4210 NH1 ARG C 118 54.769 52.242 23.231 1.00 11.15 N +ATOM 4211 NH2 ARG C 118 54.372 53.338 25.194 1.00 8.50 N +ATOM 4212 N LYS C 119 51.760 44.918 22.951 1.00 13.46 N +ATOM 4213 CA LYS C 119 51.879 43.468 23.062 1.00 11.80 C +ATOM 4214 C LYS C 119 53.257 43.020 22.609 1.00 11.25 C +ATOM 4215 O LYS C 119 54.003 43.809 22.030 1.00 13.23 O +ATOM 4216 CB LYS C 119 50.770 42.797 22.264 1.00 9.71 C +ATOM 4217 CG LYS C 119 49.394 43.099 22.839 1.00 8.50 C +ATOM 4218 CD LYS C 119 48.298 42.333 22.141 1.00 12.44 C +ATOM 4219 CE LYS C 119 46.999 42.442 22.920 1.00 18.53 C +ATOM 4220 NZ LYS C 119 45.865 41.713 22.287 1.00 28.14 N +ATOM 4221 N SER C 120 53.626 41.787 22.941 1.00 13.14 N +ATOM 4222 CA SER C 120 54.938 41.258 22.562 1.00 13.93 C +ATOM 4223 C SER C 120 54.769 40.261 21.421 1.00 11.87 C +ATOM 4224 O SER C 120 53.826 39.462 21.429 1.00 13.34 O +ATOM 4225 CB SER C 120 55.608 40.574 23.762 1.00 18.19 C +ATOM 4226 OG SER C 120 57.017 40.437 23.592 1.00 21.23 O +ATOM 4227 N LEU C 121 55.680 40.302 20.453 1.00 8.50 N +ATOM 4228 CA LEU C 121 55.608 39.406 19.311 1.00 11.08 C +ATOM 4229 C LEU C 121 56.918 39.362 18.523 1.00 19.39 C +ATOM 4230 O LEU C 121 57.469 40.407 18.157 1.00 18.34 O +ATOM 4231 CB LEU C 121 54.449 39.822 18.406 1.00 8.50 C +ATOM 4232 CG LEU C 121 54.361 39.212 17.014 1.00 10.20 C +ATOM 4233 CD1 LEU C 121 54.314 37.702 17.087 1.00 20.55 C +ATOM 4234 CD2 LEU C 121 53.130 39.729 16.329 1.00 12.41 C +ATOM 4235 N LYS C 122 57.418 38.140 18.304 1.00 21.40 N +ATOM 4236 CA LYS C 122 58.652 37.884 17.556 1.00 14.75 C +ATOM 4237 C LYS C 122 59.902 38.666 17.975 1.00 17.35 C +ATOM 4238 O LYS C 122 60.599 39.221 17.124 1.00 14.90 O +ATOM 4239 CB LYS C 122 58.405 38.069 16.064 1.00 11.31 C +ATOM 4240 CG LYS C 122 57.775 36.865 15.389 1.00 19.04 C +ATOM 4241 CD LYS C 122 58.759 35.724 15.284 1.00 24.28 C +ATOM 4242 CE LYS C 122 58.152 34.526 14.598 1.00 29.16 C +ATOM 4243 NZ LYS C 122 59.110 33.382 14.479 1.00 47.66 N +ATOM 4244 N LYS C 123 60.207 38.685 19.274 1.00 16.27 N +ATOM 4245 CA LYS C 123 61.389 39.398 19.742 1.00 14.34 C +ATOM 4246 C LYS C 123 62.639 38.754 19.136 1.00 21.51 C +ATOM 4247 O LYS C 123 62.702 37.533 18.956 1.00 29.32 O +ATOM 4248 CB LYS C 123 61.496 39.360 21.263 1.00 8.50 C +ATOM 4249 CG LYS C 123 62.729 40.076 21.758 1.00 8.50 C +ATOM 4250 CD LYS C 123 63.228 39.546 23.084 1.00 17.32 C +ATOM 4251 CE LYS C 123 62.459 40.094 24.256 1.00 10.04 C +ATOM 4252 NZ LYS C 123 63.181 39.819 25.522 1.00 10.65 N +ATOM 4253 N GLY C 124 63.628 39.570 18.802 1.00 22.13 N +ATOM 4254 CA GLY C 124 64.855 39.040 18.236 1.00 19.60 C +ATOM 4255 C GLY C 124 64.775 38.666 16.768 1.00 22.37 C +ATOM 4256 O GLY C 124 65.810 38.476 16.118 1.00 29.66 O +ATOM 4257 N TYR C 125 63.564 38.556 16.227 1.00 19.76 N +ATOM 4258 CA TYR C 125 63.400 38.204 14.813 1.00 21.09 C +ATOM 4259 C TYR C 125 63.955 39.335 13.945 1.00 21.74 C +ATOM 4260 O TYR C 125 64.330 40.399 14.445 1.00 24.21 O +ATOM 4261 CB TYR C 125 61.915 37.972 14.495 1.00 24.15 C +ATOM 4262 CG TYR C 125 61.619 37.412 13.111 1.00 23.87 C +ATOM 4263 CD1 TYR C 125 61.739 36.054 12.842 1.00 27.73 C +ATOM 4264 CD2 TYR C 125 61.209 38.249 12.072 1.00 31.49 C +ATOM 4265 CE1 TYR C 125 61.459 35.549 11.575 1.00 27.82 C +ATOM 4266 CE2 TYR C 125 60.929 37.747 10.799 1.00 26.15 C +ATOM 4267 CZ TYR C 125 61.059 36.400 10.564 1.00 21.94 C +ATOM 4268 OH TYR C 125 60.793 35.888 9.323 1.00 30.34 O +ATOM 4269 N THR C 126 64.044 39.087 12.648 1.00 21.57 N +ATOM 4270 CA THR C 126 64.524 40.087 11.708 1.00 22.65 C +ATOM 4271 C THR C 126 63.810 39.878 10.356 1.00 23.78 C +ATOM 4272 O THR C 126 63.856 38.791 9.770 1.00 23.54 O +ATOM 4273 CB THR C 126 66.067 40.069 11.621 1.00 18.21 C +ATOM 4274 OG1 THR C 126 66.502 40.693 10.413 1.00 31.74 O +ATOM 4275 CG2 THR C 126 66.611 38.664 11.708 1.00 29.56 C +ATOM 4276 N VAL C 127 63.063 40.899 9.932 1.00 23.25 N +ATOM 4277 CA VAL C 127 62.278 40.853 8.700 1.00 18.58 C +ATOM 4278 C VAL C 127 63.133 40.905 7.439 1.00 19.44 C +ATOM 4279 O VAL C 127 64.083 41.693 7.348 1.00 15.77 O +ATOM 4280 CB VAL C 127 61.218 41.989 8.688 1.00 15.41 C +ATOM 4281 CG1 VAL C 127 60.470 42.021 7.364 1.00 19.70 C +ATOM 4282 CG2 VAL C 127 60.234 41.787 9.838 1.00 9.81 C +ATOM 4283 N GLY C 128 62.775 40.065 6.467 1.00 21.87 N +ATOM 4284 CA GLY C 128 63.500 39.992 5.204 1.00 28.27 C +ATOM 4285 C GLY C 128 63.454 41.263 4.380 1.00 28.11 C +ATOM 4286 O GLY C 128 62.417 41.912 4.305 1.00 28.10 O +ATOM 4287 N ALA C 129 64.571 41.573 3.726 1.00 32.48 N +ATOM 4288 CA ALA C 129 64.715 42.775 2.914 1.00 33.53 C +ATOM 4289 C ALA C 129 64.116 42.731 1.504 1.00 40.47 C +ATOM 4290 O ALA C 129 63.616 43.747 1.010 1.00 44.51 O +ATOM 4291 CB ALA C 129 66.187 43.170 2.852 1.00 28.73 C +ATOM 4292 N GLU C 130 64.224 41.595 0.821 1.00 43.51 N +ATOM 4293 CA GLU C 130 63.664 41.496 -0.523 1.00 48.35 C +ATOM 4294 C GLU C 130 62.279 40.908 -0.397 1.00 43.41 C +ATOM 4295 O GLU C 130 62.123 39.742 -0.050 1.00 44.91 O +ATOM 4296 CB GLU C 130 64.547 40.648 -1.434 1.00 66.10 C +ATOM 4297 CG GLU C 130 64.890 39.262 -0.906 1.00 89.74 C +ATOM 4298 CD GLU C 130 65.767 38.479 -1.868 1.00 99.72 C +ATOM 4299 OE1 GLU C 130 67.010 38.616 -1.785 1.00104.76 O +ATOM 4300 OE2 GLU C 130 65.212 37.735 -2.709 1.00103.79 O +ATOM 4301 N ALA C 131 61.269 41.721 -0.673 1.00 40.21 N +ATOM 4302 CA ALA C 131 59.895 41.268 -0.515 1.00 30.92 C +ATOM 4303 C ALA C 131 58.909 41.747 -1.554 1.00 22.91 C +ATOM 4304 O ALA C 131 59.141 42.732 -2.252 1.00 29.34 O +ATOM 4305 CB ALA C 131 59.389 41.663 0.865 1.00 29.95 C +ATOM 4306 N SER C 132 57.803 41.022 -1.640 1.00 14.28 N +ATOM 4307 CA SER C 132 56.712 41.339 -2.538 1.00 18.85 C +ATOM 4308 C SER C 132 55.648 41.904 -1.618 1.00 24.23 C +ATOM 4309 O SER C 132 55.177 41.205 -0.707 1.00 21.06 O +ATOM 4310 CB SER C 132 56.176 40.083 -3.200 1.00 11.79 C +ATOM 4311 OG SER C 132 55.065 40.361 -4.039 1.00 8.50 O +ATOM 4312 N ILE C 133 55.333 43.187 -1.813 1.00 23.54 N +ATOM 4313 CA ILE C 133 54.339 43.897 -1.012 1.00 15.53 C +ATOM 4314 C ILE C 133 53.082 44.074 -1.859 1.00 13.51 C +ATOM 4315 O ILE C 133 53.104 44.766 -2.869 1.00 21.68 O +ATOM 4316 CB ILE C 133 54.883 45.271 -0.579 1.00 10.32 C +ATOM 4317 CG1 ILE C 133 56.228 45.104 0.123 1.00 8.50 C +ATOM 4318 CG2 ILE C 133 53.895 45.956 0.329 1.00 17.18 C +ATOM 4319 CD1 ILE C 133 56.886 46.400 0.504 1.00 8.50 C +ATOM 4320 N ILE C 134 51.984 43.458 -1.451 1.00 8.78 N +ATOM 4321 CA ILE C 134 50.759 43.564 -2.216 1.00 10.88 C +ATOM 4322 C ILE C 134 49.570 44.125 -1.460 1.00 12.97 C +ATOM 4323 O ILE C 134 49.360 43.841 -0.277 1.00 16.16 O +ATOM 4324 CB ILE C 134 50.414 42.218 -2.882 1.00 16.60 C +ATOM 4325 CG1 ILE C 134 51.347 42.018 -4.077 1.00 25.04 C +ATOM 4326 CG2 ILE C 134 48.940 42.146 -3.299 1.00 8.50 C +ATOM 4327 CD1 ILE C 134 51.160 40.716 -4.784 1.00 35.95 C +ATOM 4328 N LEU C 135 48.797 44.934 -2.170 1.00 8.73 N +ATOM 4329 CA LEU C 135 47.617 45.566 -1.636 1.00 8.89 C +ATOM 4330 C LEU C 135 46.376 44.933 -2.251 1.00 14.67 C +ATOM 4331 O LEU C 135 46.322 44.728 -3.463 1.00 13.09 O +ATOM 4332 CB LEU C 135 47.650 47.044 -1.994 1.00 8.50 C +ATOM 4333 CG LEU C 135 48.124 48.070 -0.969 1.00 10.22 C +ATOM 4334 CD1 LEU C 135 49.287 47.537 -0.167 1.00 13.80 C +ATOM 4335 CD2 LEU C 135 48.490 49.356 -1.675 1.00 13.84 C +ATOM 4336 N GLY C 136 45.398 44.594 -1.414 1.00 18.18 N +ATOM 4337 CA GLY C 136 44.162 44.017 -1.922 1.00 22.13 C +ATOM 4338 C GLY C 136 44.028 42.506 -2.040 1.00 25.28 C +ATOM 4339 O GLY C 136 42.913 42.015 -2.224 1.00 22.90 O +ATOM 4340 N GLN C 137 45.142 41.774 -1.981 1.00 22.02 N +ATOM 4341 CA GLN C 137 45.114 40.323 -2.088 1.00 16.12 C +ATOM 4342 C GLN C 137 45.932 39.713 -0.990 1.00 22.08 C +ATOM 4343 O GLN C 137 46.816 40.381 -0.433 1.00 19.72 O +ATOM 4344 CB GLN C 137 45.658 39.848 -3.431 1.00 8.91 C +ATOM 4345 CG GLN C 137 44.660 39.927 -4.562 1.00 8.67 C +ATOM 4346 CD GLN C 137 43.346 39.203 -4.263 1.00 29.53 C +ATOM 4347 OE1 GLN C 137 42.321 39.480 -4.906 1.00 26.93 O +ATOM 4348 NE2 GLN C 137 43.369 38.251 -3.301 1.00 25.78 N +ATOM 4349 N GLU C 138 45.646 38.444 -0.679 1.00 26.39 N +ATOM 4350 CA GLU C 138 46.382 37.752 0.380 1.00 24.56 C +ATOM 4351 C GLU C 138 47.438 36.828 -0.210 1.00 26.00 C +ATOM 4352 O GLU C 138 47.098 35.822 -0.835 1.00 30.83 O +ATOM 4353 CB GLU C 138 45.422 36.951 1.257 1.00 22.27 C +ATOM 4354 CG GLU C 138 45.934 36.711 2.673 1.00 34.91 C +ATOM 4355 CD GLU C 138 47.108 35.740 2.764 1.00 39.88 C +ATOM 4356 OE1 GLU C 138 46.866 34.512 2.847 1.00 32.32 O +ATOM 4357 OE2 GLU C 138 48.266 36.217 2.796 1.00 43.17 O +ATOM 4358 N GLN C 139 48.708 37.178 -0.024 1.00 22.20 N +ATOM 4359 CA GLN C 139 49.809 36.368 -0.536 1.00 25.23 C +ATOM 4360 C GLN C 139 50.051 35.075 0.255 1.00 37.65 C +ATOM 4361 O GLN C 139 50.093 35.061 1.500 1.00 38.74 O +ATOM 4362 CB GLN C 139 51.098 37.168 -0.563 1.00 16.26 C +ATOM 4363 CG GLN C 139 51.400 37.814 -1.872 1.00 17.58 C +ATOM 4364 CD GLN C 139 52.397 38.946 -1.720 1.00 27.71 C +ATOM 4365 OE1 GLN C 139 52.009 40.088 -1.513 1.00 38.10 O +ATOM 4366 NE2 GLN C 139 53.682 38.633 -1.785 1.00 26.41 N +ATOM 4367 N ASP C 140 50.230 33.992 -0.491 1.00 41.20 N +ATOM 4368 CA ASP C 140 50.491 32.692 0.087 1.00 43.89 C +ATOM 4369 C ASP C 140 51.708 32.094 -0.613 1.00 46.34 C +ATOM 4370 O ASP C 140 52.052 30.921 -0.430 1.00 55.50 O +ATOM 4371 CB ASP C 140 49.243 31.810 -0.016 1.00 42.84 C +ATOM 4372 CG ASP C 140 48.158 32.229 0.969 1.00 47.35 C +ATOM 4373 OD1 ASP C 140 48.513 32.580 2.120 1.00 46.98 O +ATOM 4374 OD2 ASP C 140 46.963 32.223 0.597 1.00 42.97 O +ATOM 4375 N SER C 141 52.356 32.931 -1.413 1.00 41.90 N +ATOM 4376 CA SER C 141 53.565 32.579 -2.140 1.00 43.28 C +ATOM 4377 C SER C 141 54.107 33.902 -2.630 1.00 34.53 C +ATOM 4378 O SER C 141 53.347 34.842 -2.839 1.00 37.64 O +ATOM 4379 CB SER C 141 53.263 31.647 -3.328 1.00 51.89 C +ATOM 4380 OG SER C 141 52.794 32.343 -4.469 1.00 50.01 O +ATOM 4381 N PHE C 142 55.412 33.989 -2.793 1.00 26.10 N +ATOM 4382 CA PHE C 142 56.016 35.225 -3.245 1.00 30.45 C +ATOM 4383 C PHE C 142 55.336 35.774 -4.496 1.00 34.83 C +ATOM 4384 O PHE C 142 55.531 35.282 -5.599 1.00 40.28 O +ATOM 4385 CB PHE C 142 57.504 35.013 -3.508 1.00 37.12 C +ATOM 4386 CG PHE C 142 58.296 36.282 -3.654 1.00 27.43 C +ATOM 4387 CD1 PHE C 142 58.846 36.898 -2.548 1.00 31.51 C +ATOM 4388 CD2 PHE C 142 58.545 36.819 -4.907 1.00 36.66 C +ATOM 4389 CE1 PHE C 142 59.642 38.027 -2.686 1.00 47.26 C +ATOM 4390 CE2 PHE C 142 59.340 37.951 -5.059 1.00 39.45 C +ATOM 4391 CZ PHE C 142 59.890 38.554 -3.948 1.00 46.46 C +ATOM 4392 N GLY C 143 54.495 36.779 -4.296 1.00 40.71 N +ATOM 4393 CA GLY C 143 53.817 37.426 -5.401 1.00 34.69 C +ATOM 4394 C GLY C 143 52.637 36.696 -5.987 1.00 33.21 C +ATOM 4395 O GLY C 143 52.157 37.075 -7.053 1.00 36.18 O +ATOM 4396 N GLY C 144 52.126 35.696 -5.287 1.00 29.54 N +ATOM 4397 CA GLY C 144 50.986 34.977 -5.816 1.00 37.36 C +ATOM 4398 C GLY C 144 50.224 34.108 -4.840 1.00 38.76 C +ATOM 4399 O GLY C 144 50.359 34.251 -3.627 1.00 39.25 O +ATOM 4400 N ASN C 145 49.433 33.193 -5.400 1.00 44.31 N +ATOM 4401 CA ASN C 145 48.598 32.254 -4.652 1.00 48.05 C +ATOM 4402 C ASN C 145 47.539 33.010 -3.878 1.00 43.36 C +ATOM 4403 O ASN C 145 47.430 32.895 -2.664 1.00 44.27 O +ATOM 4404 CB ASN C 145 49.448 31.379 -3.724 1.00 59.22 C +ATOM 4405 CG ASN C 145 50.089 30.194 -4.450 1.00 64.44 C +ATOM 4406 OD1 ASN C 145 50.906 30.362 -5.355 1.00 63.76 O +ATOM 4407 ND2 ASN C 145 49.733 28.991 -4.033 1.00 68.98 N +ATOM 4408 N PHE C 146 46.719 33.740 -4.621 1.00 39.78 N +ATOM 4409 CA PHE C 146 45.674 34.569 -4.046 1.00 41.53 C +ATOM 4410 C PHE C 146 44.356 33.860 -3.793 1.00 44.44 C +ATOM 4411 O PHE C 146 43.778 33.272 -4.703 1.00 50.89 O +ATOM 4412 CB PHE C 146 45.410 35.773 -4.960 1.00 35.55 C +ATOM 4413 CG PHE C 146 46.640 36.604 -5.259 1.00 32.66 C +ATOM 4414 CD1 PHE C 146 47.597 36.863 -4.278 1.00 27.38 C +ATOM 4415 CD2 PHE C 146 46.852 37.113 -6.539 1.00 30.81 C +ATOM 4416 CE1 PHE C 146 48.732 37.606 -4.575 1.00 17.60 C +ATOM 4417 CE2 PHE C 146 47.992 37.856 -6.831 1.00 13.14 C +ATOM 4418 CZ PHE C 146 48.923 38.098 -5.851 1.00 8.50 C +ATOM 4419 N GLU C 147 43.877 33.924 -2.559 1.00 43.24 N +ATOM 4420 CA GLU C 147 42.594 33.332 -2.221 1.00 45.64 C +ATOM 4421 C GLU C 147 41.572 34.452 -2.282 1.00 48.01 C +ATOM 4422 O GLU C 147 41.682 35.441 -1.553 1.00 54.44 O +ATOM 4423 CB GLU C 147 42.622 32.744 -0.823 1.00 34.74 C +ATOM 4424 CG GLU C 147 43.516 31.558 -0.713 1.00 44.77 C +ATOM 4425 CD GLU C 147 43.645 31.085 0.697 1.00 51.92 C +ATOM 4426 OE1 GLU C 147 44.306 31.807 1.489 1.00 45.27 O +ATOM 4427 OE2 GLU C 147 43.082 30.001 1.002 1.00 52.48 O +ATOM 4428 N GLY C 148 40.589 34.303 -3.162 1.00 49.26 N +ATOM 4429 CA GLY C 148 39.549 35.310 -3.325 1.00 46.76 C +ATOM 4430 C GLY C 148 38.686 35.564 -2.099 1.00 44.62 C +ATOM 4431 O GLY C 148 38.004 36.587 -2.016 1.00 49.67 O +ATOM 4432 N SER C 149 38.727 34.639 -1.146 1.00 39.28 N +ATOM 4433 CA SER C 149 37.965 34.737 0.090 1.00 41.54 C +ATOM 4434 C SER C 149 38.660 35.695 1.060 1.00 39.71 C +ATOM 4435 O SER C 149 38.170 35.957 2.163 1.00 44.63 O +ATOM 4436 CB SER C 149 37.856 33.342 0.718 1.00 51.57 C +ATOM 4437 OG SER C 149 37.004 33.320 1.852 1.00 70.15 O +ATOM 4438 N GLN C 150 39.807 36.216 0.644 1.00 30.15 N +ATOM 4439 CA GLN C 150 40.579 37.131 1.464 1.00 23.05 C +ATOM 4440 C GLN C 150 40.954 38.379 0.676 1.00 25.84 C +ATOM 4441 O GLN C 150 41.904 39.084 1.017 1.00 33.45 O +ATOM 4442 CB GLN C 150 41.833 36.416 1.959 1.00 21.53 C +ATOM 4443 CG GLN C 150 41.545 35.029 2.524 1.00 18.92 C +ATOM 4444 CD GLN C 150 42.737 34.409 3.239 1.00 34.22 C +ATOM 4445 OE1 GLN C 150 43.825 34.250 2.666 1.00 27.75 O +ATOM 4446 NE2 GLN C 150 42.533 34.038 4.505 1.00 47.63 N +ATOM 4447 N SER C 151 40.215 38.640 -0.392 1.00 26.70 N +ATOM 4448 CA SER C 151 40.478 39.798 -1.226 1.00 27.26 C +ATOM 4449 C SER C 151 39.829 41.010 -0.577 1.00 26.32 C +ATOM 4450 O SER C 151 38.929 40.856 0.258 1.00 23.96 O +ATOM 4451 CB SER C 151 39.905 39.587 -2.629 1.00 32.46 C +ATOM 4452 OG SER C 151 40.222 40.695 -3.466 1.00 60.34 O +ATOM 4453 N LEU C 152 40.305 42.208 -0.918 1.00 23.17 N +ATOM 4454 CA LEU C 152 39.710 43.412 -0.349 1.00 13.25 C +ATOM 4455 C LEU C 152 38.780 44.063 -1.357 1.00 12.32 C +ATOM 4456 O LEU C 152 39.124 44.209 -2.535 1.00 14.30 O +ATOM 4457 CB LEU C 152 40.782 44.412 0.071 1.00 8.50 C +ATOM 4458 CG LEU C 152 40.252 45.787 0.461 1.00 8.50 C +ATOM 4459 CD1 LEU C 152 39.697 45.773 1.854 1.00 9.41 C +ATOM 4460 CD2 LEU C 152 41.373 46.787 0.366 1.00 13.67 C +ATOM 4461 N VAL C 153 37.595 44.429 -0.900 1.00 8.89 N +ATOM 4462 CA VAL C 153 36.631 45.091 -1.759 1.00 11.00 C +ATOM 4463 C VAL C 153 36.317 46.431 -1.099 1.00 16.28 C +ATOM 4464 O VAL C 153 35.670 46.474 -0.036 1.00 15.99 O +ATOM 4465 CB VAL C 153 35.333 44.275 -1.911 1.00 8.50 C +ATOM 4466 CG1 VAL C 153 34.475 44.862 -3.018 1.00 17.08 C +ATOM 4467 CG2 VAL C 153 35.648 42.852 -2.195 1.00 8.50 C +ATOM 4468 N GLY C 154 36.814 47.506 -1.709 1.00 13.47 N +ATOM 4469 CA GLY C 154 36.614 48.849 -1.188 1.00 11.41 C +ATOM 4470 C GLY C 154 37.789 49.722 -1.577 1.00 12.14 C +ATOM 4471 O GLY C 154 38.443 49.460 -2.578 1.00 14.11 O +ATOM 4472 N ASP C 155 38.082 50.738 -0.782 1.00 9.73 N +ATOM 4473 CA ASP C 155 39.186 51.640 -1.078 1.00 8.50 C +ATOM 4474 C ASP C 155 40.318 51.479 -0.096 1.00 8.50 C +ATOM 4475 O ASP C 155 40.105 51.159 1.070 1.00 12.14 O +ATOM 4476 CB ASP C 155 38.715 53.089 -0.980 1.00 9.61 C +ATOM 4477 CG ASP C 155 37.732 53.470 -2.062 1.00 13.29 C +ATOM 4478 OD1 ASP C 155 36.661 52.816 -2.175 1.00 8.50 O +ATOM 4479 OD2 ASP C 155 38.027 54.458 -2.778 1.00 15.21 O +ATOM 4480 N ILE C 156 41.523 51.750 -0.552 1.00 8.50 N +ATOM 4481 CA ILE C 156 42.679 51.692 0.315 1.00 8.50 C +ATOM 4482 C ILE C 156 43.626 52.749 -0.193 1.00 8.50 C +ATOM 4483 O ILE C 156 43.762 52.930 -1.397 1.00 15.09 O +ATOM 4484 CB ILE C 156 43.350 50.319 0.315 1.00 10.95 C +ATOM 4485 CG1 ILE C 156 44.529 50.325 1.283 1.00 11.34 C +ATOM 4486 CG2 ILE C 156 43.836 49.967 -1.060 1.00 15.12 C +ATOM 4487 CD1 ILE C 156 45.169 48.995 1.443 1.00 8.71 C +ATOM 4488 N GLY C 157 44.235 53.488 0.715 1.00 8.50 N +ATOM 4489 CA GLY C 157 45.118 54.548 0.306 1.00 8.50 C +ATOM 4490 C GLY C 157 45.973 55.023 1.447 1.00 10.50 C +ATOM 4491 O GLY C 157 45.930 54.464 2.545 1.00 12.82 O +ATOM 4492 N ASN C 158 46.754 56.064 1.184 1.00 14.75 N +ATOM 4493 CA ASN C 158 47.676 56.648 2.157 1.00 10.53 C +ATOM 4494 C ASN C 158 48.583 55.654 2.869 1.00 11.68 C +ATOM 4495 O ASN C 158 48.778 55.753 4.085 1.00 10.77 O +ATOM 4496 CB ASN C 158 46.932 57.494 3.182 1.00 11.84 C +ATOM 4497 CG ASN C 158 46.691 58.879 2.706 1.00 12.76 C +ATOM 4498 OD1 ASN C 158 45.551 59.333 2.666 1.00 17.12 O +ATOM 4499 ND2 ASN C 158 47.763 59.572 2.329 1.00 21.94 N +ATOM 4500 N VAL C 159 49.132 54.698 2.120 1.00 9.86 N +ATOM 4501 CA VAL C 159 50.020 53.714 2.726 1.00 10.64 C +ATOM 4502 C VAL C 159 51.429 54.276 2.740 1.00 8.50 C +ATOM 4503 O VAL C 159 51.885 54.849 1.757 1.00 12.32 O +ATOM 4504 CB VAL C 159 49.941 52.295 2.053 1.00 8.50 C +ATOM 4505 CG1 VAL C 159 49.059 52.308 0.809 1.00 8.50 C +ATOM 4506 CG2 VAL C 159 51.334 51.761 1.744 1.00 8.50 C +ATOM 4507 N ASN C 160 52.063 54.216 3.901 1.00 9.30 N +ATOM 4508 CA ASN C 160 53.427 54.714 4.095 1.00 12.17 C +ATOM 4509 C ASN C 160 54.103 53.735 5.034 1.00 13.82 C +ATOM 4510 O ASN C 160 53.426 53.057 5.812 1.00 17.45 O +ATOM 4511 CB ASN C 160 53.424 56.111 4.734 1.00 12.02 C +ATOM 4512 CG ASN C 160 52.785 57.167 3.840 1.00 17.91 C +ATOM 4513 OD1 ASN C 160 51.611 57.507 3.998 1.00 28.78 O +ATOM 4514 ND2 ASN C 160 53.558 57.695 2.898 1.00 15.90 N +ATOM 4515 N MET C 161 55.429 53.669 4.992 1.00 11.65 N +ATOM 4516 CA MET C 161 56.165 52.726 5.834 1.00 9.54 C +ATOM 4517 C MET C 161 57.522 53.277 6.193 1.00 11.15 C +ATOM 4518 O MET C 161 58.220 53.836 5.338 1.00 13.01 O +ATOM 4519 CB MET C 161 56.327 51.397 5.098 1.00 8.55 C +ATOM 4520 CG MET C 161 57.030 50.313 5.872 1.00 16.52 C +ATOM 4521 SD MET C 161 56.956 48.723 5.001 1.00 24.17 S +ATOM 4522 CE MET C 161 57.514 47.598 6.265 1.00 10.26 C +ATOM 4523 N TRP C 162 57.874 53.147 7.466 1.00 11.25 N +ATOM 4524 CA TRP C 162 59.157 53.614 7.969 1.00 12.55 C +ATOM 4525 C TRP C 162 59.932 52.384 8.438 1.00 14.68 C +ATOM 4526 O TRP C 162 59.325 51.355 8.748 1.00 16.33 O +ATOM 4527 CB TRP C 162 58.945 54.546 9.161 1.00 11.28 C +ATOM 4528 CG TRP C 162 58.238 55.839 8.861 1.00 13.90 C +ATOM 4529 CD1 TRP C 162 58.801 57.095 8.797 1.00 18.62 C +ATOM 4530 CD2 TRP C 162 56.837 56.025 8.674 1.00 8.50 C +ATOM 4531 NE1 TRP C 162 57.825 58.039 8.591 1.00 10.81 N +ATOM 4532 CE2 TRP C 162 56.613 57.407 8.511 1.00 9.48 C +ATOM 4533 CE3 TRP C 162 55.742 55.157 8.634 1.00 14.39 C +ATOM 4534 CZ2 TRP C 162 55.338 57.933 8.310 1.00 19.74 C +ATOM 4535 CZ3 TRP C 162 54.462 55.692 8.433 1.00 11.62 C +ATOM 4536 CH2 TRP C 162 54.276 57.056 8.274 1.00 10.11 C +ATOM 4537 N ASP C 163 61.260 52.480 8.482 1.00 13.58 N +ATOM 4538 CA ASP C 163 62.075 51.364 8.945 1.00 11.89 C +ATOM 4539 C ASP C 163 62.381 51.458 10.442 1.00 15.68 C +ATOM 4540 O ASP C 163 63.232 50.721 10.967 1.00 18.67 O +ATOM 4541 CB ASP C 163 63.365 51.221 8.121 1.00 12.55 C +ATOM 4542 CG ASP C 163 64.339 52.398 8.283 1.00 22.20 C +ATOM 4543 OD1 ASP C 163 64.344 53.099 9.324 1.00 11.44 O +ATOM 4544 OD2 ASP C 163 65.142 52.597 7.345 1.00 33.58 O +ATOM 4545 N PHE C 164 61.720 52.399 11.114 1.00 10.87 N +ATOM 4546 CA PHE C 164 61.892 52.594 12.552 1.00 12.92 C +ATOM 4547 C PHE C 164 60.519 52.786 13.186 1.00 12.03 C +ATOM 4548 O PHE C 164 59.521 52.917 12.472 1.00 12.36 O +ATOM 4549 CB PHE C 164 62.814 53.782 12.857 1.00 20.30 C +ATOM 4550 CG PHE C 164 62.300 55.104 12.356 1.00 17.44 C +ATOM 4551 CD1 PHE C 164 62.559 55.512 11.051 1.00 17.03 C +ATOM 4552 CD2 PHE C 164 61.572 55.949 13.195 1.00 8.50 C +ATOM 4553 CE1 PHE C 164 62.098 56.750 10.587 1.00 19.74 C +ATOM 4554 CE2 PHE C 164 61.112 57.180 12.742 1.00 11.02 C +ATOM 4555 CZ PHE C 164 61.372 57.586 11.438 1.00 16.16 C +ATOM 4556 N VAL C 165 60.472 52.813 14.516 1.00 13.07 N +ATOM 4557 CA VAL C 165 59.205 52.948 15.229 1.00 12.59 C +ATOM 4558 C VAL C 165 58.794 54.388 15.518 1.00 12.56 C +ATOM 4559 O VAL C 165 59.468 55.099 16.266 1.00 15.13 O +ATOM 4560 CB VAL C 165 59.210 52.145 16.562 1.00 14.91 C +ATOM 4561 CG1 VAL C 165 57.823 52.179 17.206 1.00 21.49 C +ATOM 4562 CG2 VAL C 165 59.633 50.699 16.309 1.00 17.16 C +ATOM 4563 N LEU C 166 57.673 54.803 14.934 1.00 12.96 N +ATOM 4564 CA LEU C 166 57.145 56.145 15.138 1.00 10.00 C +ATOM 4565 C LEU C 166 56.723 56.330 16.582 1.00 8.50 C +ATOM 4566 O LEU C 166 56.235 55.397 17.231 1.00 9.91 O +ATOM 4567 CB LEU C 166 55.943 56.384 14.225 1.00 10.31 C +ATOM 4568 CG LEU C 166 56.158 57.211 12.956 1.00 8.50 C +ATOM 4569 CD1 LEU C 166 57.341 56.706 12.214 1.00 8.50 C +ATOM 4570 CD2 LEU C 166 54.908 57.163 12.108 1.00 8.50 C +ATOM 4571 N SER C 167 56.936 57.535 17.090 1.00 10.11 N +ATOM 4572 CA SER C 167 56.554 57.847 18.468 1.00 15.79 C +ATOM 4573 C SER C 167 55.092 58.244 18.488 1.00 14.26 C +ATOM 4574 O SER C 167 54.494 58.511 17.433 1.00 17.88 O +ATOM 4575 CB SER C 167 57.412 58.998 19.040 1.00 26.78 C +ATOM 4576 OG SER C 167 57.100 60.272 18.472 1.00 35.15 O +ATOM 4577 N PRO C 168 54.497 58.310 19.683 1.00 10.68 N +ATOM 4578 CA PRO C 168 53.087 58.687 19.804 1.00 14.98 C +ATOM 4579 C PRO C 168 52.789 60.047 19.158 1.00 18.77 C +ATOM 4580 O PRO C 168 51.752 60.229 18.513 1.00 25.38 O +ATOM 4581 CB PRO C 168 52.895 58.737 21.315 1.00 16.97 C +ATOM 4582 CG PRO C 168 53.801 57.653 21.783 1.00 8.50 C +ATOM 4583 CD PRO C 168 55.040 57.905 20.986 1.00 8.50 C +ATOM 4584 N ASP C 169 53.715 60.987 19.312 1.00 16.88 N +ATOM 4585 CA ASP C 169 53.541 62.317 18.756 1.00 17.08 C +ATOM 4586 C ASP C 169 53.602 62.282 17.237 1.00 17.11 C +ATOM 4587 O ASP C 169 52.799 62.946 16.565 1.00 24.85 O +ATOM 4588 CB ASP C 169 54.599 63.275 19.316 1.00 31.18 C +ATOM 4589 CG ASP C 169 54.516 63.426 20.845 1.00 37.15 C +ATOM 4590 OD1 ASP C 169 53.470 63.907 21.350 1.00 42.27 O +ATOM 4591 OD2 ASP C 169 55.503 63.068 21.536 1.00 37.47 O +ATOM 4592 N GLU C 170 54.527 61.494 16.694 1.00 10.78 N +ATOM 4593 CA GLU C 170 54.658 61.382 15.250 1.00 9.71 C +ATOM 4594 C GLU C 170 53.402 60.692 14.719 1.00 10.06 C +ATOM 4595 O GLU C 170 52.716 61.228 13.853 1.00 12.11 O +ATOM 4596 CB GLU C 170 55.919 60.600 14.892 1.00 8.50 C +ATOM 4597 CG GLU C 170 57.183 61.164 15.515 1.00 19.84 C +ATOM 4598 CD GLU C 170 58.455 60.429 15.092 1.00 32.67 C +ATOM 4599 OE1 GLU C 170 58.823 60.495 13.893 1.00 42.17 O +ATOM 4600 OE2 GLU C 170 59.106 59.806 15.964 1.00 30.97 O +ATOM 4601 N ILE C 171 53.045 59.561 15.317 1.00 8.72 N +ATOM 4602 CA ILE C 171 51.870 58.813 14.893 1.00 10.76 C +ATOM 4603 C ILE C 171 50.661 59.703 14.915 1.00 12.71 C +ATOM 4604 O ILE C 171 49.736 59.554 14.103 1.00 12.69 O +ATOM 4605 CB ILE C 171 51.635 57.598 15.781 1.00 10.45 C +ATOM 4606 CG1 ILE C 171 52.714 56.563 15.472 1.00 14.82 C +ATOM 4607 CG2 ILE C 171 50.240 57.021 15.564 1.00 8.50 C +ATOM 4608 CD1 ILE C 171 52.592 55.291 16.265 1.00 37.73 C +ATOM 4609 N ASN C 172 50.693 60.673 15.816 1.00 17.44 N +ATOM 4610 CA ASN C 172 49.590 61.604 15.929 1.00 21.09 C +ATOM 4611 C ASN C 172 49.570 62.581 14.760 1.00 16.52 C +ATOM 4612 O ASN C 172 48.525 62.741 14.124 1.00 19.25 O +ATOM 4613 CB ASN C 172 49.625 62.363 17.249 1.00 30.37 C +ATOM 4614 CG ASN C 172 48.399 63.210 17.444 1.00 38.62 C +ATOM 4615 OD1 ASN C 172 48.443 64.435 17.302 1.00 41.13 O +ATOM 4616 ND2 ASN C 172 47.277 62.559 17.736 1.00 40.60 N +ATOM 4617 N THR C 173 50.705 63.202 14.439 1.00 8.50 N +ATOM 4618 CA THR C 173 50.696 64.132 13.319 1.00 9.75 C +ATOM 4619 C THR C 173 50.333 63.400 12.028 1.00 8.76 C +ATOM 4620 O THR C 173 49.567 63.918 11.226 1.00 10.17 O +ATOM 4621 CB THR C 173 52.025 64.921 13.142 1.00 15.63 C +ATOM 4622 OG1 THR C 173 52.918 64.193 12.296 1.00 14.71 O +ATOM 4623 CG2 THR C 173 52.707 65.204 14.487 1.00 16.28 C +ATOM 4624 N ILE C 174 50.834 62.182 11.840 1.00 9.52 N +ATOM 4625 CA ILE C 174 50.492 61.423 10.640 1.00 9.35 C +ATOM 4626 C ILE C 174 48.977 61.363 10.540 1.00 10.12 C +ATOM 4627 O ILE C 174 48.408 61.658 9.489 1.00 10.18 O +ATOM 4628 CB ILE C 174 51.046 59.965 10.662 1.00 9.30 C +ATOM 4629 CG1 ILE C 174 52.507 59.940 10.213 1.00 11.10 C +ATOM 4630 CG2 ILE C 174 50.282 59.095 9.688 1.00 13.16 C +ATOM 4631 CD1 ILE C 174 53.483 60.387 11.243 1.00 13.38 C +ATOM 4632 N TYR C 175 48.325 61.014 11.649 1.00 10.78 N +ATOM 4633 CA TYR C 175 46.871 60.918 11.667 1.00 11.29 C +ATOM 4634 C TYR C 175 46.181 62.237 11.351 1.00 21.30 C +ATOM 4635 O TYR C 175 45.277 62.282 10.506 1.00 27.06 O +ATOM 4636 CB TYR C 175 46.373 60.438 13.019 1.00 8.50 C +ATOM 4637 CG TYR C 175 44.857 60.427 13.120 1.00 9.92 C +ATOM 4638 CD1 TYR C 175 44.076 59.801 12.149 1.00 13.00 C +ATOM 4639 CD2 TYR C 175 44.210 61.026 14.191 1.00 17.16 C +ATOM 4640 CE1 TYR C 175 42.698 59.766 12.245 1.00 19.86 C +ATOM 4641 CE2 TYR C 175 42.823 61.004 14.303 1.00 27.30 C +ATOM 4642 CZ TYR C 175 42.067 60.372 13.331 1.00 30.43 C +ATOM 4643 OH TYR C 175 40.685 60.342 13.452 1.00 37.95 O +ATOM 4644 N LEU C 176 46.599 63.287 12.060 1.00 22.67 N +ATOM 4645 CA LEU C 176 46.043 64.627 11.923 1.00 20.64 C +ATOM 4646 C LEU C 176 46.369 65.339 10.629 1.00 24.50 C +ATOM 4647 O LEU C 176 45.842 66.426 10.377 1.00 28.46 O +ATOM 4648 CB LEU C 176 46.486 65.488 13.106 1.00 21.56 C +ATOM 4649 CG LEU C 176 45.422 65.774 14.177 1.00 22.91 C +ATOM 4650 CD1 LEU C 176 44.278 64.754 14.132 1.00 28.90 C +ATOM 4651 CD2 LEU C 176 46.086 65.804 15.532 1.00 14.84 C +ATOM 4652 N GLY C 177 47.243 64.747 9.821 1.00 27.10 N +ATOM 4653 CA GLY C 177 47.609 65.363 8.553 1.00 34.31 C +ATOM 4654 C GLY C 177 48.702 66.405 8.712 1.00 38.25 C +ATOM 4655 O GLY C 177 48.532 67.591 8.404 1.00 44.50 O +ATOM 4656 N GLY C 178 49.812 65.973 9.283 1.00 41.28 N +ATOM 4657 CA GLY C 178 50.926 66.875 9.453 1.00 39.21 C +ATOM 4658 C GLY C 178 51.938 66.481 8.394 1.00 39.81 C +ATOM 4659 O GLY C 178 51.650 65.637 7.531 1.00 37.31 O +ATOM 4660 N PRO C 179 53.101 67.143 8.373 1.00 38.47 N +ATOM 4661 CA PRO C 179 54.132 66.812 7.387 1.00 36.85 C +ATOM 4662 C PRO C 179 55.113 65.787 7.972 1.00 35.13 C +ATOM 4663 O PRO C 179 55.496 65.873 9.157 1.00 36.69 O +ATOM 4664 CB PRO C 179 54.793 68.168 7.134 1.00 42.67 C +ATOM 4665 CG PRO C 179 54.762 68.805 8.498 1.00 38.87 C +ATOM 4666 CD PRO C 179 53.387 68.433 9.041 1.00 39.97 C +ATOM 4667 N PHE C 180 55.520 64.828 7.144 1.00 31.27 N +ATOM 4668 CA PHE C 180 56.451 63.785 7.574 1.00 31.76 C +ATOM 4669 C PHE C 180 57.119 63.185 6.345 1.00 30.49 C +ATOM 4670 O PHE C 180 56.654 63.410 5.215 1.00 28.28 O +ATOM 4671 CB PHE C 180 55.695 62.690 8.334 1.00 36.60 C +ATOM 4672 CG PHE C 180 54.482 62.190 7.600 1.00 38.80 C +ATOM 4673 CD1 PHE C 180 53.245 62.829 7.750 1.00 44.84 C +ATOM 4674 CD2 PHE C 180 54.579 61.106 6.727 1.00 37.60 C +ATOM 4675 CE1 PHE C 180 52.117 62.395 7.036 1.00 44.83 C +ATOM 4676 CE2 PHE C 180 53.461 60.660 6.006 1.00 41.59 C +ATOM 4677 CZ PHE C 180 52.227 61.305 6.161 1.00 45.68 C +ATOM 4678 N SER C 181 58.179 62.407 6.573 1.00 29.42 N +ATOM 4679 CA SER C 181 58.908 61.760 5.485 1.00 31.12 C +ATOM 4680 C SER C 181 59.198 60.275 5.735 1.00 30.68 C +ATOM 4681 O SER C 181 60.078 59.919 6.542 1.00 36.35 O +ATOM 4682 CB SER C 181 60.214 62.499 5.200 1.00 33.51 C +ATOM 4683 OG SER C 181 60.174 63.120 3.931 1.00 53.98 O +ATOM 4684 N PRO C 182 58.424 59.386 5.083 1.00 24.11 N +ATOM 4685 CA PRO C 182 58.588 57.939 5.216 1.00 23.10 C +ATOM 4686 C PRO C 182 59.934 57.595 4.591 1.00 26.43 C +ATOM 4687 O PRO C 182 60.466 58.395 3.812 1.00 33.00 O +ATOM 4688 CB PRO C 182 57.460 57.397 4.348 1.00 22.43 C +ATOM 4689 CG PRO C 182 56.459 58.484 4.358 1.00 18.72 C +ATOM 4690 CD PRO C 182 57.306 59.685 4.180 1.00 17.04 C +ATOM 4691 N ASN C 183 60.484 56.422 4.892 1.00 23.79 N +ATOM 4692 CA ASN C 183 61.768 56.066 4.299 1.00 18.01 C +ATOM 4693 C ASN C 183 61.830 54.642 3.761 1.00 19.48 C +ATOM 4694 O ASN C 183 62.916 54.055 3.666 1.00 29.82 O +ATOM 4695 CB ASN C 183 62.927 56.352 5.266 1.00 20.40 C +ATOM 4696 CG ASN C 183 62.944 55.418 6.466 1.00 22.83 C +ATOM 4697 OD1 ASN C 183 61.992 54.650 6.712 1.00 18.04 O +ATOM 4698 ND2 ASN C 183 64.035 55.475 7.224 1.00 19.17 N +ATOM 4699 N VAL C 184 60.664 54.080 3.445 1.00 11.63 N +ATOM 4700 CA VAL C 184 60.575 52.739 2.864 1.00 11.66 C +ATOM 4701 C VAL C 184 59.494 52.837 1.787 1.00 15.18 C +ATOM 4702 O VAL C 184 59.782 52.717 0.601 1.00 22.01 O +ATOM 4703 CB VAL C 184 60.187 51.643 3.899 1.00 16.47 C +ATOM 4704 CG1 VAL C 184 60.048 50.300 3.219 1.00 8.50 C +ATOM 4705 CG2 VAL C 184 61.225 51.542 4.995 1.00 19.91 C +ATOM 4706 N LEU C 185 58.258 53.096 2.203 1.00 13.72 N +ATOM 4707 CA LEU C 185 57.145 53.247 1.271 1.00 11.33 C +ATOM 4708 C LEU C 185 56.677 54.678 1.462 1.00 14.64 C +ATOM 4709 O LEU C 185 56.470 55.104 2.595 1.00 15.71 O +ATOM 4710 CB LEU C 185 56.013 52.277 1.608 1.00 10.41 C +ATOM 4711 CG LEU C 185 55.740 51.173 0.600 1.00 8.50 C +ATOM 4712 CD1 LEU C 185 57.032 50.511 0.262 1.00 16.58 C +ATOM 4713 CD2 LEU C 185 54.768 50.179 1.166 1.00 8.50 C +ATOM 4714 N ASN C 186 56.545 55.420 0.367 1.00 16.59 N +ATOM 4715 CA ASN C 186 56.127 56.813 0.429 1.00 14.77 C +ATOM 4716 C ASN C 186 54.972 57.036 -0.528 1.00 15.18 C +ATOM 4717 O ASN C 186 55.151 56.927 -1.741 1.00 20.95 O +ATOM 4718 CB ASN C 186 57.319 57.716 0.050 1.00 23.24 C +ATOM 4719 CG ASN C 186 57.032 59.199 0.232 1.00 16.31 C +ATOM 4720 OD1 ASN C 186 55.886 59.643 0.148 1.00 8.50 O +ATOM 4721 ND2 ASN C 186 58.083 59.972 0.473 1.00 16.65 N +ATOM 4722 N TRP C 187 53.802 57.370 0.014 1.00 11.78 N +ATOM 4723 CA TRP C 187 52.610 57.615 -0.805 1.00 11.28 C +ATOM 4724 C TRP C 187 52.762 58.814 -1.760 1.00 12.36 C +ATOM 4725 O TRP C 187 52.034 58.938 -2.742 1.00 16.43 O +ATOM 4726 CB TRP C 187 51.393 57.816 0.084 1.00 8.50 C +ATOM 4727 CG TRP C 187 50.084 57.672 -0.624 1.00 8.50 C +ATOM 4728 CD1 TRP C 187 49.157 58.648 -0.834 1.00 8.50 C +ATOM 4729 CD2 TRP C 187 49.530 56.470 -1.180 1.00 10.51 C +ATOM 4730 NE1 TRP C 187 48.057 58.135 -1.480 1.00 8.57 N +ATOM 4731 CE2 TRP C 187 48.260 56.800 -1.706 1.00 11.81 C +ATOM 4732 CE3 TRP C 187 49.979 55.151 -1.282 1.00 8.50 C +ATOM 4733 CZ2 TRP C 187 47.438 55.857 -2.326 1.00 11.26 C +ATOM 4734 CZ3 TRP C 187 49.160 54.216 -1.897 1.00 8.50 C +ATOM 4735 CH2 TRP C 187 47.907 54.573 -2.410 1.00 8.50 C +ATOM 4736 N ARG C 188 53.715 59.684 -1.469 1.00 9.63 N +ATOM 4737 CA ARG C 188 53.987 60.856 -2.284 1.00 20.46 C +ATOM 4738 C ARG C 188 54.917 60.533 -3.476 1.00 28.71 C +ATOM 4739 O ARG C 188 54.977 61.280 -4.468 1.00 33.75 O +ATOM 4740 CB ARG C 188 54.649 61.916 -1.386 1.00 24.96 C +ATOM 4741 CG ARG C 188 53.858 63.209 -1.218 1.00 35.37 C +ATOM 4742 CD ARG C 188 53.885 63.706 0.214 1.00 36.64 C +ATOM 4743 NE ARG C 188 52.539 63.707 0.799 1.00 43.55 N +ATOM 4744 CZ ARG C 188 52.257 63.404 2.071 1.00 49.74 C +ATOM 4745 NH1 ARG C 188 53.230 63.069 2.931 1.00 34.14 N +ATOM 4746 NH2 ARG C 188 50.987 63.419 2.479 1.00 46.09 N +ATOM 4747 N ALA C 189 55.645 59.425 -3.363 1.00 27.41 N +ATOM 4748 CA ALA C 189 56.569 58.982 -4.395 1.00 20.63 C +ATOM 4749 C ALA C 189 56.410 57.471 -4.460 1.00 21.72 C +ATOM 4750 O ALA C 189 57.369 56.722 -4.253 1.00 28.04 O +ATOM 4751 CB ALA C 189 57.981 59.352 -4.003 1.00 14.83 C +ATOM 4752 N LEU C 190 55.182 57.029 -4.711 1.00 16.36 N +ATOM 4753 CA LEU C 190 54.884 55.609 -4.772 1.00 21.87 C +ATOM 4754 C LEU C 190 55.289 55.015 -6.127 1.00 25.20 C +ATOM 4755 O LEU C 190 55.155 55.661 -7.173 1.00 27.00 O +ATOM 4756 CB LEU C 190 53.387 55.370 -4.498 1.00 13.17 C +ATOM 4757 CG LEU C 190 52.993 53.949 -4.097 1.00 8.50 C +ATOM 4758 CD1 LEU C 190 53.314 53.740 -2.654 1.00 8.50 C +ATOM 4759 CD2 LEU C 190 51.531 53.727 -4.344 1.00 14.72 C +ATOM 4760 N LYS C 191 55.849 53.813 -6.094 1.00 28.96 N +ATOM 4761 CA LYS C 191 56.248 53.111 -7.305 1.00 29.11 C +ATOM 4762 C LYS C 191 55.452 51.801 -7.238 1.00 25.95 C +ATOM 4763 O LYS C 191 55.765 50.897 -6.460 1.00 24.05 O +ATOM 4764 CB LYS C 191 57.758 52.872 -7.278 1.00 41.55 C +ATOM 4765 CG LYS C 191 58.401 52.744 -8.655 1.00 63.30 C +ATOM 4766 CD LYS C 191 59.909 52.975 -8.589 1.00 78.41 C +ATOM 4767 CE LYS C 191 60.555 52.911 -9.973 1.00 90.10 C +ATOM 4768 NZ LYS C 191 61.999 53.310 -9.956 1.00 93.60 N +ATOM 4769 N TYR C 192 54.395 51.720 -8.026 1.00 22.31 N +ATOM 4770 CA TYR C 192 53.538 50.554 -7.982 1.00 26.31 C +ATOM 4771 C TYR C 192 53.228 49.978 -9.356 1.00 32.85 C +ATOM 4772 O TYR C 192 53.625 50.534 -10.385 1.00 39.13 O +ATOM 4773 CB TYR C 192 52.226 50.933 -7.291 1.00 23.58 C +ATOM 4774 CG TYR C 192 51.452 51.997 -8.038 1.00 22.15 C +ATOM 4775 CD1 TYR C 192 51.867 53.345 -8.018 1.00 19.20 C +ATOM 4776 CD2 TYR C 192 50.333 51.662 -8.794 1.00 9.82 C +ATOM 4777 CE1 TYR C 192 51.190 54.327 -8.732 1.00 8.50 C +ATOM 4778 CE2 TYR C 192 49.650 52.643 -9.519 1.00 21.41 C +ATOM 4779 CZ TYR C 192 50.083 53.973 -9.485 1.00 17.34 C +ATOM 4780 OH TYR C 192 49.395 54.917 -10.221 1.00 20.13 O +ATOM 4781 N GLU C 193 52.452 48.897 -9.354 1.00 35.59 N +ATOM 4782 CA GLU C 193 52.041 48.205 -10.563 1.00 35.79 C +ATOM 4783 C GLU C 193 50.653 47.640 -10.274 1.00 34.41 C +ATOM 4784 O GLU C 193 50.445 46.906 -9.306 1.00 34.58 O +ATOM 4785 CB GLU C 193 53.030 47.086 -10.862 1.00 46.58 C +ATOM 4786 CG GLU C 193 52.975 46.545 -12.273 1.00 68.85 C +ATOM 4787 CD GLU C 193 54.021 45.472 -12.508 1.00 78.40 C +ATOM 4788 OE1 GLU C 193 53.740 44.295 -12.187 1.00 83.85 O +ATOM 4789 OE2 GLU C 193 55.126 45.808 -12.998 1.00 85.02 O +ATOM 4790 N VAL C 194 49.688 48.050 -11.078 1.00 34.06 N +ATOM 4791 CA VAL C 194 48.306 47.616 -10.915 1.00 34.57 C +ATOM 4792 C VAL C 194 48.047 46.358 -11.737 1.00 35.16 C +ATOM 4793 O VAL C 194 48.656 46.160 -12.794 1.00 38.62 O +ATOM 4794 CB VAL C 194 47.325 48.747 -11.359 1.00 38.23 C +ATOM 4795 CG1 VAL C 194 45.873 48.255 -11.339 1.00 33.67 C +ATOM 4796 CG2 VAL C 194 47.481 49.955 -10.457 1.00 35.29 C +ATOM 4797 N GLN C 195 47.137 45.519 -11.259 1.00 33.78 N +ATOM 4798 CA GLN C 195 46.807 44.291 -11.961 1.00 33.09 C +ATOM 4799 C GLN C 195 45.355 43.950 -11.718 1.00 27.97 C +ATOM 4800 O GLN C 195 44.925 43.803 -10.569 1.00 31.52 O +ATOM 4801 CB GLN C 195 47.677 43.145 -11.443 1.00 49.65 C +ATOM 4802 CG GLN C 195 47.971 42.069 -12.463 1.00 63.56 C +ATOM 4803 CD GLN C 195 48.852 42.581 -13.584 1.00 74.52 C +ATOM 4804 OE1 GLN C 195 48.433 42.614 -14.740 1.00 87.31 O +ATOM 4805 NE2 GLN C 195 50.075 42.992 -13.249 1.00 69.17 N +ATOM 4806 N GLY C 196 44.588 43.857 -12.790 1.00 22.11 N +ATOM 4807 CA GLY C 196 43.190 43.503 -12.643 1.00 26.09 C +ATOM 4808 C GLY C 196 42.223 44.661 -12.580 1.00 27.48 C +ATOM 4809 O GLY C 196 42.487 45.741 -13.099 1.00 34.76 O +ATOM 4810 N GLU C 197 41.102 44.429 -11.916 1.00 25.80 N +ATOM 4811 CA GLU C 197 40.041 45.419 -11.780 1.00 21.22 C +ATOM 4812 C GLU C 197 40.258 46.398 -10.631 1.00 19.16 C +ATOM 4813 O GLU C 197 39.550 46.345 -9.625 1.00 27.23 O +ATOM 4814 CB GLU C 197 38.708 44.694 -11.578 1.00 25.63 C +ATOM 4815 CG GLU C 197 37.481 45.547 -11.769 1.00 32.63 C +ATOM 4816 CD GLU C 197 36.973 45.553 -13.207 1.00 41.33 C +ATOM 4817 OE1 GLU C 197 37.781 45.305 -14.146 1.00 38.70 O +ATOM 4818 OE2 GLU C 197 35.753 45.814 -13.384 1.00 41.43 O +ATOM 4819 N VAL C 198 41.251 47.265 -10.765 1.00 13.33 N +ATOM 4820 CA VAL C 198 41.533 48.261 -9.746 1.00 10.88 C +ATOM 4821 C VAL C 198 41.729 49.611 -10.418 1.00 15.34 C +ATOM 4822 O VAL C 198 42.424 49.720 -11.434 1.00 19.07 O +ATOM 4823 CB VAL C 198 42.738 47.868 -8.828 1.00 11.08 C +ATOM 4824 CG1 VAL C 198 43.510 46.723 -9.396 1.00 15.95 C +ATOM 4825 CG2 VAL C 198 43.663 49.038 -8.598 1.00 16.31 C +ATOM 4826 N PHE C 199 41.056 50.626 -9.875 1.00 16.97 N +ATOM 4827 CA PHE C 199 41.109 51.995 -10.408 1.00 16.86 C +ATOM 4828 C PHE C 199 41.669 52.986 -9.393 1.00 15.01 C +ATOM 4829 O PHE C 199 41.690 52.713 -8.188 1.00 17.45 O +ATOM 4830 CB PHE C 199 39.703 52.460 -10.794 1.00 13.23 C +ATOM 4831 CG PHE C 199 38.926 51.452 -11.595 1.00 17.73 C +ATOM 4832 CD1 PHE C 199 38.199 50.453 -10.967 1.00 9.71 C +ATOM 4833 CD2 PHE C 199 38.915 51.513 -12.982 1.00 28.45 C +ATOM 4834 CE1 PHE C 199 37.482 49.541 -11.702 1.00 11.00 C +ATOM 4835 CE2 PHE C 199 38.197 50.602 -13.723 1.00 24.43 C +ATOM 4836 CZ PHE C 199 37.482 49.616 -13.080 1.00 21.93 C +ATOM 4837 N THR C 200 42.084 54.144 -9.892 1.00 9.46 N +ATOM 4838 CA THR C 200 42.622 55.200 -9.056 1.00 10.31 C +ATOM 4839 C THR C 200 41.597 56.335 -9.062 1.00 12.45 C +ATOM 4840 O THR C 200 41.327 56.922 -10.101 1.00 21.54 O +ATOM 4841 CB THR C 200 43.958 55.720 -9.600 1.00 8.50 C +ATOM 4842 OG1 THR C 200 44.891 54.644 -9.687 1.00 21.95 O +ATOM 4843 CG2 THR C 200 44.531 56.756 -8.690 1.00 8.50 C +ATOM 4844 N LYS C 201 40.982 56.597 -7.915 1.00 14.45 N +ATOM 4845 CA LYS C 201 39.982 57.646 -7.789 1.00 9.50 C +ATOM 4846 C LYS C 201 40.308 58.541 -6.580 1.00 9.18 C +ATOM 4847 O LYS C 201 41.191 58.218 -5.785 1.00 8.50 O +ATOM 4848 CB LYS C 201 38.586 57.020 -7.639 1.00 9.14 C +ATOM 4849 CG LYS C 201 38.058 56.294 -8.861 1.00 8.50 C +ATOM 4850 CD LYS C 201 38.135 57.160 -10.107 1.00 21.11 C +ATOM 4851 CE LYS C 201 37.092 56.763 -11.159 1.00 26.82 C +ATOM 4852 NZ LYS C 201 35.699 57.058 -10.705 1.00 27.83 N +ATOM 4853 N PRO C 202 39.644 59.708 -6.467 1.00 9.01 N +ATOM 4854 CA PRO C 202 39.864 60.641 -5.359 1.00 9.13 C +ATOM 4855 C PRO C 202 39.441 59.993 -4.045 1.00 12.21 C +ATOM 4856 O PRO C 202 38.386 59.376 -3.980 1.00 17.53 O +ATOM 4857 CB PRO C 202 38.922 61.788 -5.698 1.00 9.11 C +ATOM 4858 CG PRO C 202 38.814 61.723 -7.163 1.00 10.96 C +ATOM 4859 CD PRO C 202 38.659 60.270 -7.404 1.00 8.98 C +ATOM 4860 N GLN C 203 40.227 60.171 -2.991 1.00 8.50 N +ATOM 4861 CA GLN C 203 39.901 59.560 -1.705 1.00 8.80 C +ATOM 4862 C GLN C 203 38.631 60.099 -1.068 1.00 11.55 C +ATOM 4863 O GLN C 203 38.357 61.303 -1.132 1.00 12.05 O +ATOM 4864 CB GLN C 203 41.055 59.723 -0.732 1.00 12.09 C +ATOM 4865 CG GLN C 203 41.464 61.142 -0.474 1.00 8.50 C +ATOM 4866 CD GLN C 203 42.564 61.211 0.546 1.00 17.58 C +ATOM 4867 OE1 GLN C 203 42.477 61.961 1.507 1.00 33.12 O +ATOM 4868 NE2 GLN C 203 43.610 60.413 0.352 1.00 19.80 N +ATOM 4869 N LEU C 204 37.888 59.208 -0.411 1.00 12.53 N +ATOM 4870 CA LEU C 204 36.635 59.575 0.249 1.00 10.83 C +ATOM 4871 C LEU C 204 36.831 60.105 1.654 1.00 10.93 C +ATOM 4872 O LEU C 204 35.985 60.832 2.180 1.00 14.87 O +ATOM 4873 CB LEU C 204 35.681 58.392 0.293 1.00 9.97 C +ATOM 4874 CG LEU C 204 35.467 57.783 -1.074 1.00 8.50 C +ATOM 4875 CD1 LEU C 204 36.413 56.618 -1.159 1.00 23.62 C +ATOM 4876 CD2 LEU C 204 34.041 57.357 -1.250 1.00 8.50 C +ATOM 4877 N TRP C 205 37.891 59.650 2.302 1.00 12.09 N +ATOM 4878 CA TRP C 205 38.198 60.127 3.641 1.00 19.85 C +ATOM 4879 C TRP C 205 38.885 61.464 3.459 1.00 26.23 C +ATOM 4880 O TRP C 205 39.511 61.697 2.425 1.00 36.36 O +ATOM 4881 CB TRP C 205 39.120 59.156 4.388 1.00 17.16 C +ATOM 4882 CG TRP C 205 40.222 58.621 3.571 1.00 11.04 C +ATOM 4883 CD1 TRP C 205 41.441 59.190 3.364 1.00 15.03 C +ATOM 4884 CD2 TRP C 205 40.224 57.384 2.861 1.00 8.50 C +ATOM 4885 NE1 TRP C 205 42.209 58.375 2.568 1.00 21.11 N +ATOM 4886 CE2 TRP C 205 41.484 57.258 2.248 1.00 10.44 C +ATOM 4887 CE3 TRP C 205 39.279 56.370 2.683 1.00 8.50 C +ATOM 4888 CZ2 TRP C 205 41.827 56.164 1.476 1.00 11.90 C +ATOM 4889 CZ3 TRP C 205 39.617 55.286 1.916 1.00 13.75 C +ATOM 4890 CH2 TRP C 205 40.884 55.189 1.321 1.00 19.07 C +ATOM 4891 N PRO C 206 38.723 62.379 4.424 1.00 27.70 N +ATOM 4892 CA PRO C 206 39.338 63.702 4.355 1.00 30.31 C +ATOM 4893 C PRO C 206 40.821 63.697 4.730 1.00 36.29 C +ATOM 4894 O PRO C 206 41.546 64.566 4.192 1.00 42.92 O +ATOM 4895 CB PRO C 206 38.499 64.501 5.344 1.00 30.70 C +ATOM 4896 CG PRO C 206 38.217 63.498 6.394 1.00 26.24 C +ATOM 4897 CD PRO C 206 37.830 62.283 5.590 1.00 28.87 C +ATOM 4898 OXT PRO C 206 41.239 62.839 5.548 1.00 35.01 O +TER 4899 PRO C 206 +ATOM 4900 N GLN D 1 10.925 76.290 -17.190 1.00 62.43 N +ATOM 4901 CA GLN D 1 11.828 77.442 -17.018 1.00 51.93 C +ATOM 4902 C GLN D 1 11.415 78.149 -15.734 1.00 51.33 C +ATOM 4903 O GLN D 1 11.107 79.330 -15.763 1.00 58.19 O +ATOM 4904 CB GLN D 1 11.538 78.396 -18.173 1.00 53.25 C +ATOM 4905 CG GLN D 1 12.092 77.985 -19.481 1.00 58.21 C +ATOM 4906 CD GLN D 1 13.587 78.076 -19.448 1.00 71.80 C +ATOM 4907 OE1 GLN D 1 14.209 77.640 -18.479 1.00 67.92 O +ATOM 4908 NE2 GLN D 1 14.180 78.687 -20.473 1.00 80.48 N +ATOM 4909 N THR D 2 11.363 77.435 -14.621 1.00 42.67 N +ATOM 4910 CA THR D 2 10.930 78.043 -13.383 1.00 31.34 C +ATOM 4911 C THR D 2 12.032 77.942 -12.367 1.00 28.32 C +ATOM 4912 O THR D 2 12.738 76.940 -12.322 1.00 34.75 O +ATOM 4913 CB THR D 2 9.702 77.314 -12.856 1.00 29.79 C +ATOM 4914 OG1 THR D 2 8.748 77.157 -13.920 1.00 43.14 O +ATOM 4915 CG2 THR D 2 9.070 78.089 -11.719 1.00 45.93 C +ATOM 4916 N ASP D 3 12.232 79.007 -11.600 1.00 26.25 N +ATOM 4917 CA ASP D 3 13.257 78.987 -10.573 1.00 22.39 C +ATOM 4918 C ASP D 3 12.613 78.351 -9.357 1.00 28.02 C +ATOM 4919 O ASP D 3 11.866 79.016 -8.619 1.00 31.14 O +ATOM 4920 CB ASP D 3 13.737 80.392 -10.243 1.00 15.12 C +ATOM 4921 CG ASP D 3 15.061 80.388 -9.516 1.00 16.75 C +ATOM 4922 OD1 ASP D 3 15.469 79.329 -9.015 1.00 21.59 O +ATOM 4923 OD2 ASP D 3 15.707 81.443 -9.453 1.00 31.39 O +ATOM 4924 N MET D 4 12.868 77.055 -9.180 1.00 22.60 N +ATOM 4925 CA MET D 4 12.294 76.315 -8.080 1.00 15.02 C +ATOM 4926 C MET D 4 13.042 76.495 -6.772 1.00 15.20 C +ATOM 4927 O MET D 4 12.795 75.748 -5.819 1.00 20.89 O +ATOM 4928 CB MET D 4 12.203 74.848 -8.445 1.00 8.50 C +ATOM 4929 CG MET D 4 11.148 74.533 -9.450 1.00 8.50 C +ATOM 4930 SD MET D 4 9.559 75.048 -8.865 1.00 9.15 S +ATOM 4931 CE MET D 4 9.128 73.758 -7.787 1.00 8.50 C +ATOM 4932 N SER D 5 13.919 77.495 -6.709 1.00 8.50 N +ATOM 4933 CA SER D 5 14.695 77.769 -5.511 1.00 8.50 C +ATOM 4934 C SER D 5 13.857 77.970 -4.262 1.00 16.20 C +ATOM 4935 O SER D 5 12.864 78.697 -4.286 1.00 26.24 O +ATOM 4936 CB SER D 5 15.530 79.006 -5.705 1.00 17.18 C +ATOM 4937 OG SER D 5 16.629 78.727 -6.534 1.00 38.34 O +ATOM 4938 N ARG D 6 14.284 77.345 -3.165 1.00 13.00 N +ATOM 4939 CA ARG D 6 13.597 77.447 -1.880 1.00 11.91 C +ATOM 4940 C ARG D 6 12.211 76.805 -1.874 1.00 14.28 C +ATOM 4941 O ARG D 6 11.442 76.978 -0.925 1.00 19.32 O +ATOM 4942 CB ARG D 6 13.519 78.913 -1.396 1.00 8.50 C +ATOM 4943 CG ARG D 6 14.636 79.388 -0.387 1.00 28.80 C +ATOM 4944 CD ARG D 6 16.060 79.023 -0.853 1.00 38.50 C +ATOM 4945 NE ARG D 6 17.162 79.686 -0.140 1.00 49.43 N +ATOM 4946 CZ ARG D 6 17.735 79.262 0.993 1.00 59.67 C +ATOM 4947 NH1 ARG D 6 17.310 78.155 1.607 1.00 53.08 N +ATOM 4948 NH2 ARG D 6 18.804 79.913 1.470 1.00 52.08 N +ATOM 4949 N LYS D 7 11.913 76.020 -2.905 1.00 14.25 N +ATOM 4950 CA LYS D 7 10.633 75.332 -3.016 1.00 9.59 C +ATOM 4951 C LYS D 7 10.790 73.804 -3.070 1.00 14.75 C +ATOM 4952 O LYS D 7 11.900 73.271 -3.300 1.00 13.62 O +ATOM 4953 CB LYS D 7 9.869 75.848 -4.221 1.00 8.50 C +ATOM 4954 CG LYS D 7 9.353 77.246 -4.012 1.00 9.24 C +ATOM 4955 CD LYS D 7 9.016 77.906 -5.325 1.00 33.59 C +ATOM 4956 CE LYS D 7 8.591 79.349 -5.143 1.00 46.25 C +ATOM 4957 NZ LYS D 7 8.493 80.044 -6.464 1.00 63.70 N +ATOM 4958 N ALA D 8 9.687 73.103 -2.807 1.00 11.87 N +ATOM 4959 CA ALA D 8 9.672 71.654 -2.807 1.00 8.50 C +ATOM 4960 C ALA D 8 8.316 71.213 -3.260 1.00 8.50 C +ATOM 4961 O ALA D 8 7.353 71.930 -3.069 1.00 8.50 O +ATOM 4962 CB ALA D 8 9.925 71.150 -1.412 1.00 12.58 C +ATOM 4963 N PHE D 9 8.251 70.067 -3.927 1.00 10.59 N +ATOM 4964 CA PHE D 9 6.982 69.504 -4.380 1.00 8.50 C +ATOM 4965 C PHE D 9 6.526 68.683 -3.193 1.00 8.50 C +ATOM 4966 O PHE D 9 7.340 67.983 -2.582 1.00 8.50 O +ATOM 4967 CB PHE D 9 7.176 68.574 -5.577 1.00 8.50 C +ATOM 4968 CG PHE D 9 7.570 69.269 -6.848 1.00 8.50 C +ATOM 4969 CD1 PHE D 9 6.728 70.175 -7.454 1.00 8.50 C +ATOM 4970 CD2 PHE D 9 8.774 68.964 -7.476 1.00 12.18 C +ATOM 4971 CE1 PHE D 9 7.078 70.757 -8.658 1.00 8.50 C +ATOM 4972 CE2 PHE D 9 9.124 69.551 -8.689 1.00 8.50 C +ATOM 4973 CZ PHE D 9 8.272 70.445 -9.274 1.00 8.50 C +ATOM 4974 N VAL D 10 5.252 68.778 -2.844 1.00 8.50 N +ATOM 4975 CA VAL D 10 4.745 68.021 -1.716 1.00 8.89 C +ATOM 4976 C VAL D 10 3.524 67.168 -2.050 1.00 11.04 C +ATOM 4977 O VAL D 10 2.511 67.679 -2.518 1.00 9.01 O +ATOM 4978 CB VAL D 10 4.508 68.934 -0.461 1.00 10.59 C +ATOM 4979 CG1 VAL D 10 4.168 70.324 -0.862 1.00 8.50 C +ATOM 4980 CG2 VAL D 10 3.411 68.385 0.425 1.00 10.48 C +ATOM 4981 N PHE D 11 3.677 65.853 -1.861 1.00 12.08 N +ATOM 4982 CA PHE D 11 2.634 64.857 -2.114 1.00 13.44 C +ATOM 4983 C PHE D 11 2.050 64.516 -0.745 1.00 10.42 C +ATOM 4984 O PHE D 11 2.565 63.651 -0.051 1.00 13.57 O +ATOM 4985 CB PHE D 11 3.267 63.603 -2.748 1.00 15.58 C +ATOM 4986 CG PHE D 11 4.102 63.880 -3.973 1.00 8.50 C +ATOM 4987 CD1 PHE D 11 3.545 63.859 -5.229 1.00 8.50 C +ATOM 4988 CD2 PHE D 11 5.435 64.128 -3.863 1.00 8.50 C +ATOM 4989 CE1 PHE D 11 4.317 64.080 -6.344 1.00 15.26 C +ATOM 4990 CE2 PHE D 11 6.208 64.347 -4.981 1.00 8.50 C +ATOM 4991 CZ PHE D 11 5.653 64.323 -6.215 1.00 8.50 C +ATOM 4992 N PRO D 12 0.964 65.179 -0.351 1.00 8.58 N +ATOM 4993 CA PRO D 12 0.285 64.990 0.937 1.00 11.95 C +ATOM 4994 C PRO D 12 -0.350 63.648 1.235 1.00 21.35 C +ATOM 4995 O PRO D 12 -0.461 63.286 2.413 1.00 32.17 O +ATOM 4996 CB PRO D 12 -0.782 66.082 0.936 1.00 14.72 C +ATOM 4997 CG PRO D 12 -0.269 67.079 -0.072 1.00 17.81 C +ATOM 4998 CD PRO D 12 0.274 66.194 -1.148 1.00 10.57 C +ATOM 4999 N LYS D 13 -0.853 62.949 0.214 1.00 28.27 N +ATOM 5000 CA LYS D 13 -1.472 61.644 0.455 1.00 33.77 C +ATOM 5001 C LYS D 13 -1.136 60.560 -0.542 1.00 37.19 C +ATOM 5002 O LYS D 13 -0.715 60.852 -1.677 1.00 37.86 O +ATOM 5003 CB LYS D 13 -2.988 61.750 0.654 1.00 36.48 C +ATOM 5004 CG LYS D 13 -3.746 62.636 -0.322 1.00 42.40 C +ATOM 5005 CD LYS D 13 -5.197 62.804 0.160 1.00 53.02 C +ATOM 5006 CE LYS D 13 -5.990 63.819 -0.662 1.00 60.81 C +ATOM 5007 NZ LYS D 13 -6.195 63.392 -2.077 1.00 71.10 N +ATOM 5008 N GLU D 14 -1.306 59.316 -0.089 1.00 38.40 N +ATOM 5009 CA GLU D 14 -1.023 58.122 -0.879 1.00 45.61 C +ATOM 5010 C GLU D 14 -1.903 58.105 -2.139 1.00 43.98 C +ATOM 5011 O GLU D 14 -3.133 58.128 -2.054 1.00 43.19 O +ATOM 5012 CB GLU D 14 -1.249 56.904 0.018 1.00 59.23 C +ATOM 5013 CG GLU D 14 -0.767 57.142 1.455 1.00 65.19 C +ATOM 5014 CD GLU D 14 -0.959 55.947 2.367 1.00 75.49 C +ATOM 5015 OE1 GLU D 14 -2.117 55.651 2.744 1.00 75.75 O +ATOM 5016 OE2 GLU D 14 0.059 55.314 2.719 1.00 77.98 O +ATOM 5017 N SER D 15 -1.261 58.118 -3.304 1.00 43.52 N +ATOM 5018 CA SER D 15 -1.991 58.144 -4.546 1.00 42.17 C +ATOM 5019 C SER D 15 -1.501 57.138 -5.567 1.00 43.66 C +ATOM 5020 O SER D 15 -0.494 56.441 -5.385 1.00 38.45 O +ATOM 5021 CB SER D 15 -2.012 59.568 -5.135 1.00 50.63 C +ATOM 5022 OG SER D 15 -0.708 60.127 -5.234 1.00 66.52 O +ATOM 5023 N ASP D 16 -2.271 57.072 -6.638 1.00 45.22 N +ATOM 5024 CA ASP D 16 -2.045 56.185 -7.743 1.00 44.81 C +ATOM 5025 C ASP D 16 -1.862 57.122 -8.940 1.00 43.41 C +ATOM 5026 O ASP D 16 -1.273 56.753 -9.963 1.00 44.67 O +ATOM 5027 CB ASP D 16 -3.339 55.368 -7.897 1.00 56.43 C +ATOM 5028 CG ASP D 16 -3.134 54.045 -8.605 1.00 73.22 C +ATOM 5029 OD1 ASP D 16 -2.004 53.508 -8.570 1.00 85.39 O +ATOM 5030 OD2 ASP D 16 -4.121 53.531 -9.180 1.00 75.59 O +ATOM 5031 N THR D 17 -2.294 58.368 -8.744 1.00 39.38 N +ATOM 5032 CA THR D 17 -2.300 59.391 -9.778 1.00 40.83 C +ATOM 5033 C THR D 17 -1.340 60.577 -9.691 1.00 40.97 C +ATOM 5034 O THR D 17 -1.108 61.252 -10.704 1.00 47.63 O +ATOM 5035 CB THR D 17 -3.726 59.964 -9.884 1.00 40.93 C +ATOM 5036 OG1 THR D 17 -4.196 60.291 -8.562 1.00 34.83 O +ATOM 5037 CG2 THR D 17 -4.666 58.939 -10.509 1.00 48.53 C +ATOM 5038 N SER D 18 -0.828 60.869 -8.500 1.00 32.30 N +ATOM 5039 CA SER D 18 0.052 62.012 -8.330 1.00 22.80 C +ATOM 5040 C SER D 18 1.506 61.766 -8.703 1.00 19.11 C +ATOM 5041 O SER D 18 2.089 60.760 -8.316 1.00 8.50 O +ATOM 5042 CB SER D 18 -0.041 62.532 -6.900 1.00 24.77 C +ATOM 5043 OG SER D 18 -1.381 62.839 -6.549 1.00 33.17 O +ATOM 5044 N TYR D 19 2.079 62.712 -9.450 1.00 19.32 N +ATOM 5045 CA TYR D 19 3.479 62.673 -9.880 1.00 13.76 C +ATOM 5046 C TYR D 19 3.865 63.983 -10.589 1.00 12.98 C +ATOM 5047 O TYR D 19 2.999 64.786 -10.959 1.00 16.53 O +ATOM 5048 CB TYR D 19 3.741 61.459 -10.800 1.00 14.78 C +ATOM 5049 CG TYR D 19 3.105 61.510 -12.186 1.00 15.44 C +ATOM 5050 CD1 TYR D 19 3.748 62.133 -13.240 1.00 16.25 C +ATOM 5051 CD2 TYR D 19 1.866 60.937 -12.432 1.00 20.67 C +ATOM 5052 CE1 TYR D 19 3.176 62.189 -14.499 1.00 30.04 C +ATOM 5053 CE2 TYR D 19 1.283 60.985 -13.698 1.00 31.17 C +ATOM 5054 CZ TYR D 19 1.945 61.614 -14.726 1.00 30.80 C +ATOM 5055 OH TYR D 19 1.382 61.678 -15.985 1.00 45.04 O +ATOM 5056 N VAL D 20 5.162 64.192 -10.764 1.00 10.12 N +ATOM 5057 CA VAL D 20 5.684 65.366 -11.444 1.00 9.68 C +ATOM 5058 C VAL D 20 6.642 64.875 -12.505 1.00 15.63 C +ATOM 5059 O VAL D 20 7.566 64.109 -12.205 1.00 12.00 O +ATOM 5060 CB VAL D 20 6.461 66.273 -10.499 1.00 8.50 C +ATOM 5061 CG1 VAL D 20 7.063 67.423 -11.262 1.00 8.50 C +ATOM 5062 CG2 VAL D 20 5.542 66.799 -9.456 1.00 14.26 C +ATOM 5063 N SER D 21 6.407 65.299 -13.744 1.00 17.39 N +ATOM 5064 CA SER D 21 7.249 64.904 -14.861 1.00 17.06 C +ATOM 5065 C SER D 21 8.293 65.964 -15.115 1.00 15.02 C +ATOM 5066 O SER D 21 7.957 67.136 -15.215 1.00 20.44 O +ATOM 5067 CB SER D 21 6.403 64.729 -16.117 1.00 21.69 C +ATOM 5068 OG SER D 21 7.201 64.279 -17.203 1.00 47.22 O +ATOM 5069 N LEU D 22 9.547 65.549 -15.211 1.00 8.50 N +ATOM 5070 CA LEU D 22 10.643 66.453 -15.455 1.00 9.30 C +ATOM 5071 C LEU D 22 11.088 66.287 -16.901 1.00 20.63 C +ATOM 5072 O LEU D 22 11.279 65.162 -17.376 1.00 24.08 O +ATOM 5073 CB LEU D 22 11.790 66.149 -14.495 1.00 9.09 C +ATOM 5074 CG LEU D 22 11.911 66.967 -13.207 1.00 16.62 C +ATOM 5075 CD1 LEU D 22 10.551 67.264 -12.570 1.00 8.50 C +ATOM 5076 CD2 LEU D 22 12.836 66.230 -12.246 1.00 15.70 C +ATOM 5077 N LYS D 23 11.233 67.411 -17.602 1.00 27.81 N +ATOM 5078 CA LYS D 23 11.649 67.420 -19.004 1.00 30.09 C +ATOM 5079 C LYS D 23 13.108 67.805 -19.142 1.00 32.36 C +ATOM 5080 O LYS D 23 13.506 68.916 -18.811 1.00 31.80 O +ATOM 5081 CB LYS D 23 10.801 68.394 -19.820 1.00 22.34 C +ATOM 5082 CG LYS D 23 9.292 68.371 -19.505 1.00 33.33 C +ATOM 5083 CD LYS D 23 8.524 67.285 -20.257 1.00 39.07 C +ATOM 5084 CE LYS D 23 7.009 67.357 -19.960 1.00 39.42 C +ATOM 5085 NZ LYS D 23 6.205 66.194 -20.513 1.00 21.29 N +ATOM 5086 N ALA D 24 13.906 66.866 -19.620 1.00 44.06 N +ATOM 5087 CA ALA D 24 15.329 67.094 -19.817 1.00 56.08 C +ATOM 5088 C ALA D 24 15.607 67.134 -21.306 1.00 66.22 C +ATOM 5089 O ALA D 24 15.137 66.277 -22.054 1.00 72.09 O +ATOM 5090 CB ALA D 24 16.138 65.976 -19.178 1.00 65.15 C +ATOM 5091 N PRO D 25 16.326 68.165 -21.767 1.00 74.55 N +ATOM 5092 CA PRO D 25 16.665 68.311 -23.188 1.00 78.72 C +ATOM 5093 C PRO D 25 17.935 67.517 -23.527 1.00 81.43 C +ATOM 5094 O PRO D 25 18.984 68.080 -23.861 1.00 82.47 O +ATOM 5095 CB PRO D 25 16.865 69.817 -23.328 1.00 82.24 C +ATOM 5096 CG PRO D 25 17.471 70.186 -22.002 1.00 83.28 C +ATOM 5097 CD PRO D 25 16.669 69.382 -21.005 1.00 79.50 C +ATOM 5098 N LEU D 26 17.824 66.197 -23.434 1.00 82.91 N +ATOM 5099 CA LEU D 26 18.948 65.314 -23.692 1.00 82.61 C +ATOM 5100 C LEU D 26 19.044 64.929 -25.160 1.00 84.55 C +ATOM 5101 O LEU D 26 18.034 64.668 -25.820 1.00 83.27 O +ATOM 5102 CB LEU D 26 18.837 64.076 -22.803 1.00 79.56 C +ATOM 5103 CG LEU D 26 20.090 63.634 -22.045 1.00 73.75 C +ATOM 5104 CD1 LEU D 26 20.906 64.833 -21.570 1.00 69.16 C +ATOM 5105 CD2 LEU D 26 19.654 62.762 -20.876 1.00 68.26 C +ATOM 5106 N THR D 27 20.274 64.937 -25.661 1.00 87.79 N +ATOM 5107 CA THR D 27 20.564 64.602 -27.051 1.00 89.53 C +ATOM 5108 C THR D 27 21.502 63.397 -27.142 1.00 82.30 C +ATOM 5109 O THR D 27 21.279 62.473 -27.930 1.00 81.98 O +ATOM 5110 CB THR D 27 21.222 65.810 -27.780 1.00 99.07 C +ATOM 5111 OG1 THR D 27 22.310 66.322 -26.987 1.00 98.62 O +ATOM 5112 CG2 THR D 27 20.189 66.923 -28.036 1.00 99.49 C +ATOM 5113 N LYS D 28 22.576 63.448 -26.363 1.00 75.54 N +ATOM 5114 CA LYS D 28 23.570 62.382 -26.323 1.00 70.74 C +ATOM 5115 C LYS D 28 23.199 61.400 -25.222 1.00 61.74 C +ATOM 5116 O LYS D 28 22.645 61.800 -24.192 1.00 66.33 O +ATOM 5117 CB LYS D 28 24.960 62.965 -26.013 1.00 77.91 C +ATOM 5118 CG LYS D 28 25.682 63.619 -27.186 1.00 88.54 C +ATOM 5119 CD LYS D 28 26.260 62.573 -28.142 1.00100.31 C +ATOM 5120 CE LYS D 28 27.046 63.216 -29.283 1.00101.96 C +ATOM 5121 NZ LYS D 28 27.674 62.198 -30.176 1.00102.53 N +ATOM 5122 N PRO D 29 23.418 60.095 -25.457 1.00 49.34 N +ATOM 5123 CA PRO D 29 23.106 59.082 -24.445 1.00 45.15 C +ATOM 5124 C PRO D 29 24.155 59.156 -23.312 1.00 39.32 C +ATOM 5125 O PRO D 29 25.326 59.474 -23.552 1.00 36.34 O +ATOM 5126 CB PRO D 29 23.169 57.781 -25.246 1.00 50.43 C +ATOM 5127 CG PRO D 29 24.185 58.085 -26.302 1.00 51.51 C +ATOM 5128 CD PRO D 29 23.781 59.465 -26.736 1.00 47.16 C +ATOM 5129 N LEU D 30 23.729 58.871 -22.083 1.00 33.51 N +ATOM 5130 CA LEU D 30 24.608 58.958 -20.916 1.00 24.51 C +ATOM 5131 C LEU D 30 25.621 57.831 -20.724 1.00 18.23 C +ATOM 5132 O LEU D 30 25.268 56.657 -20.720 1.00 9.52 O +ATOM 5133 CB LEU D 30 23.787 59.147 -19.616 1.00 18.78 C +ATOM 5134 CG LEU D 30 22.950 60.409 -19.321 1.00 8.50 C +ATOM 5135 CD1 LEU D 30 23.380 61.577 -20.176 1.00 8.50 C +ATOM 5136 CD2 LEU D 30 21.485 60.117 -19.538 1.00 8.50 C +ATOM 5137 N LYS D 31 26.871 58.234 -20.504 1.00 17.47 N +ATOM 5138 CA LYS D 31 27.991 57.338 -20.259 1.00 14.10 C +ATOM 5139 C LYS D 31 28.445 57.458 -18.802 1.00 17.18 C +ATOM 5140 O LYS D 31 29.397 56.782 -18.370 1.00 16.37 O +ATOM 5141 CB LYS D 31 29.161 57.704 -21.179 1.00 26.28 C +ATOM 5142 CG LYS D 31 29.029 57.181 -22.613 1.00 48.42 C +ATOM 5143 CD LYS D 31 29.100 55.645 -22.654 1.00 62.33 C +ATOM 5144 CE LYS D 31 28.854 55.081 -24.048 1.00 64.40 C +ATOM 5145 NZ LYS D 31 28.928 53.595 -24.049 1.00 72.67 N +ATOM 5146 N ALA D 32 27.790 58.364 -18.074 1.00 18.98 N +ATOM 5147 CA ALA D 32 28.034 58.654 -16.656 1.00 9.86 C +ATOM 5148 C ALA D 32 26.988 59.670 -16.238 1.00 8.50 C +ATOM 5149 O ALA D 32 26.326 60.258 -17.090 1.00 11.50 O +ATOM 5150 CB ALA D 32 29.399 59.234 -16.464 1.00 8.50 C +ATOM 5151 N PHE D 33 26.805 59.858 -14.939 1.00 8.62 N +ATOM 5152 CA PHE D 33 25.824 60.824 -14.437 1.00 11.19 C +ATOM 5153 C PHE D 33 25.892 60.962 -12.920 1.00 11.96 C +ATOM 5154 O PHE D 33 26.451 60.103 -12.247 1.00 13.06 O +ATOM 5155 CB PHE D 33 24.388 60.439 -14.854 1.00 14.43 C +ATOM 5156 CG PHE D 33 23.882 59.141 -14.253 1.00 15.53 C +ATOM 5157 CD1 PHE D 33 23.223 59.135 -13.034 1.00 8.50 C +ATOM 5158 CD2 PHE D 33 24.030 57.934 -14.932 1.00 13.38 C +ATOM 5159 CE1 PHE D 33 22.722 57.959 -12.511 1.00 8.50 C +ATOM 5160 CE2 PHE D 33 23.525 56.757 -14.400 1.00 12.17 C +ATOM 5161 CZ PHE D 33 22.872 56.771 -13.193 1.00 8.50 C +ATOM 5162 N THR D 34 25.364 62.066 -12.403 1.00 8.50 N +ATOM 5163 CA THR D 34 25.309 62.325 -10.976 1.00 8.50 C +ATOM 5164 C THR D 34 23.957 62.957 -10.775 1.00 8.50 C +ATOM 5165 O THR D 34 23.583 63.853 -11.525 1.00 10.30 O +ATOM 5166 CB THR D 34 26.327 63.347 -10.514 1.00 8.50 C +ATOM 5167 OG1 THR D 34 27.637 62.948 -10.903 1.00 8.50 O +ATOM 5168 CG2 THR D 34 26.283 63.477 -9.022 1.00 8.50 C +ATOM 5169 N VAL D 35 23.182 62.447 -9.834 1.00 8.50 N +ATOM 5170 CA VAL D 35 21.880 63.016 -9.558 1.00 8.50 C +ATOM 5171 C VAL D 35 21.798 63.181 -8.059 1.00 10.93 C +ATOM 5172 O VAL D 35 22.126 62.259 -7.318 1.00 9.88 O +ATOM 5173 CB VAL D 35 20.691 62.177 -10.142 1.00 8.50 C +ATOM 5174 CG1 VAL D 35 21.111 60.791 -10.440 1.00 12.10 C +ATOM 5175 CG2 VAL D 35 19.506 62.164 -9.202 1.00 8.50 C +ATOM 5176 N CYS D 36 21.493 64.405 -7.628 1.00 13.54 N +ATOM 5177 CA CYS D 36 21.362 64.739 -6.214 1.00 9.13 C +ATOM 5178 C CYS D 36 19.949 65.247 -5.984 1.00 8.50 C +ATOM 5179 O CYS D 36 19.320 65.772 -6.898 1.00 8.50 O +ATOM 5180 CB CYS D 36 22.350 65.821 -5.829 1.00 8.50 C +ATOM 5181 SG CYS D 36 24.070 65.385 -6.129 1.00 8.50 S +ATOM 5182 N LEU D 37 19.435 65.040 -4.780 1.00 8.50 N +ATOM 5183 CA LEU D 37 18.106 65.499 -4.431 1.00 8.50 C +ATOM 5184 C LEU D 37 17.900 65.499 -2.921 1.00 8.50 C +ATOM 5185 O LEU D 37 18.695 64.933 -2.175 1.00 10.03 O +ATOM 5186 CB LEU D 37 17.047 64.659 -5.141 1.00 8.50 C +ATOM 5187 CG LEU D 37 16.955 63.156 -4.915 1.00 8.50 C +ATOM 5188 CD1 LEU D 37 16.064 62.846 -3.758 1.00 8.50 C +ATOM 5189 CD2 LEU D 37 16.379 62.519 -6.146 1.00 8.50 C +ATOM 5190 N HIS D 38 16.846 66.160 -2.473 1.00 8.50 N +ATOM 5191 CA HIS D 38 16.507 66.253 -1.068 1.00 8.50 C +ATOM 5192 C HIS D 38 15.096 65.677 -0.954 1.00 8.50 C +ATOM 5193 O HIS D 38 14.232 66.019 -1.754 1.00 13.08 O +ATOM 5194 CB HIS D 38 16.438 67.726 -0.699 1.00 15.06 C +ATOM 5195 CG HIS D 38 17.385 68.156 0.378 1.00 16.54 C +ATOM 5196 ND1 HIS D 38 18.354 69.117 0.172 1.00 13.99 N +ATOM 5197 CD2 HIS D 38 17.451 67.837 1.694 1.00 14.22 C +ATOM 5198 CE1 HIS D 38 18.975 69.370 1.312 1.00 14.14 C +ATOM 5199 NE2 HIS D 38 18.443 68.608 2.253 1.00 8.68 N +ATOM 5200 N PHE D 39 14.854 64.793 0.003 1.00 8.50 N +ATOM 5201 CA PHE D 39 13.518 64.252 0.174 1.00 8.50 C +ATOM 5202 C PHE D 39 13.234 64.129 1.659 1.00 8.50 C +ATOM 5203 O PHE D 39 14.150 64.132 2.470 1.00 8.50 O +ATOM 5204 CB PHE D 39 13.315 62.918 -0.587 1.00 11.52 C +ATOM 5205 CG PHE D 39 14.011 61.706 0.035 1.00 12.46 C +ATOM 5206 CD1 PHE D 39 15.348 61.444 -0.218 1.00 8.50 C +ATOM 5207 CD2 PHE D 39 13.322 60.840 0.877 1.00 8.50 C +ATOM 5208 CE1 PHE D 39 15.969 60.366 0.354 1.00 8.50 C +ATOM 5209 CE2 PHE D 39 13.944 59.771 1.445 1.00 8.50 C +ATOM 5210 CZ PHE D 39 15.260 59.534 1.188 1.00 8.50 C +ATOM 5211 N TYR D 40 11.964 64.074 2.021 1.00 8.50 N +ATOM 5212 CA TYR D 40 11.598 63.972 3.418 1.00 8.50 C +ATOM 5213 C TYR D 40 10.282 63.242 3.517 1.00 9.73 C +ATOM 5214 O TYR D 40 9.245 63.811 3.173 1.00 13.46 O +ATOM 5215 CB TYR D 40 11.439 65.370 3.992 1.00 8.50 C +ATOM 5216 CG TYR D 40 11.071 65.432 5.447 1.00 8.50 C +ATOM 5217 CD1 TYR D 40 11.428 64.423 6.303 1.00 8.50 C +ATOM 5218 CD2 TYR D 40 10.388 66.515 5.962 1.00 8.50 C +ATOM 5219 CE1 TYR D 40 11.127 64.472 7.638 1.00 8.50 C +ATOM 5220 CE2 TYR D 40 10.076 66.580 7.298 1.00 15.10 C +ATOM 5221 CZ TYR D 40 10.451 65.550 8.132 1.00 17.07 C +ATOM 5222 OH TYR D 40 10.163 65.590 9.469 1.00 26.57 O +ATOM 5223 N THR D 41 10.321 61.997 3.996 1.00 10.46 N +ATOM 5224 CA THR D 41 9.121 61.182 4.127 1.00 10.34 C +ATOM 5225 C THR D 41 9.072 60.383 5.425 1.00 16.53 C +ATOM 5226 O THR D 41 10.090 60.221 6.109 1.00 16.79 O +ATOM 5227 CB THR D 41 8.974 60.215 2.947 1.00 8.50 C +ATOM 5228 OG1 THR D 41 7.746 59.478 3.078 1.00 8.50 O +ATOM 5229 CG2 THR D 41 10.147 59.285 2.894 1.00 8.50 C +ATOM 5230 N GLU D 42 7.896 59.831 5.724 1.00 21.16 N +ATOM 5231 CA GLU D 42 7.704 59.079 6.946 1.00 27.62 C +ATOM 5232 C GLU D 42 7.720 57.565 6.860 1.00 32.14 C +ATOM 5233 O GLU D 42 6.890 56.889 7.404 1.00 40.40 O +ATOM 5234 CB GLU D 42 6.486 59.596 7.725 1.00 33.53 C +ATOM 5235 CG GLU D 42 6.690 59.676 9.241 1.00 46.43 C +ATOM 5236 CD GLU D 42 5.690 60.621 9.917 1.00 55.53 C +ATOM 5237 OE1 GLU D 42 4.536 60.195 10.193 1.00 45.09 O +ATOM 5238 OE2 GLU D 42 6.067 61.798 10.161 1.00 63.26 O +ATOM 5239 N LEU D 43 8.980 57.143 6.749 1.00 40.66 N +ATOM 5240 CA LEU D 43 9.385 55.737 6.745 1.00 54.42 C +ATOM 5241 C LEU D 43 8.391 54.821 7.491 1.00 62.54 C +ATOM 5242 O LEU D 43 8.514 54.587 8.706 1.00 57.52 O +ATOM 5243 CB LEU D 43 10.773 55.646 7.390 1.00 57.11 C +ATOM 5244 CG LEU D 43 11.073 56.550 8.592 1.00 63.49 C +ATOM 5245 CD1 LEU D 43 11.103 55.695 9.857 1.00 68.62 C +ATOM 5246 CD2 LEU D 43 12.409 57.304 8.398 1.00 57.77 C +ATOM 5247 N SER D 44 7.396 54.332 6.749 1.00 71.17 N +ATOM 5248 CA SER D 44 6.341 53.498 7.313 1.00 74.80 C +ATOM 5249 C SER D 44 6.514 52.008 7.044 1.00 78.54 C +ATOM 5250 O SER D 44 7.627 51.471 7.123 1.00 74.94 O +ATOM 5251 CB SER D 44 4.970 53.980 6.802 1.00 73.71 C +ATOM 5252 OG SER D 44 4.811 53.729 5.413 1.00 70.36 O +ATOM 5253 N SER D 45 5.396 51.359 6.713 1.00 84.48 N +ATOM 5254 CA SER D 45 5.326 49.930 6.432 1.00 85.92 C +ATOM 5255 C SER D 45 6.399 49.472 5.461 1.00 90.05 C +ATOM 5256 O SER D 45 7.143 50.279 4.897 1.00 97.08 O +ATOM 5257 CB SER D 45 3.947 49.581 5.854 1.00 75.82 C +ATOM 5258 OG SER D 45 2.908 50.306 6.504 1.00 75.15 O +ATOM 5259 N THR D 46 6.458 48.163 5.263 1.00 90.68 N +ATOM 5260 CA THR D 46 7.415 47.563 4.348 1.00 91.93 C +ATOM 5261 C THR D 46 7.324 48.232 2.959 1.00 95.00 C +ATOM 5262 O THR D 46 8.303 48.241 2.196 1.00 99.46 O +ATOM 5263 CB THR D 46 7.200 46.016 4.283 1.00 88.11 C +ATOM 5264 OG1 THR D 46 7.884 45.388 5.378 1.00 75.01 O +ATOM 5265 CG2 THR D 46 7.676 45.427 2.966 1.00 86.86 C +ATOM 5266 N ARG D 47 6.158 48.813 2.653 1.00 88.95 N +ATOM 5267 CA ARG D 47 5.937 49.514 1.380 1.00 74.22 C +ATOM 5268 C ARG D 47 6.796 50.789 1.273 1.00 56.86 C +ATOM 5269 O ARG D 47 6.537 51.813 1.931 1.00 31.08 O +ATOM 5270 CB ARG D 47 4.437 49.809 1.146 1.00 80.78 C +ATOM 5271 CG ARG D 47 3.617 50.104 2.408 1.00 97.95 C +ATOM 5272 CD ARG D 47 3.184 51.576 2.528 1.00109.52 C +ATOM 5273 NE ARG D 47 1.740 51.753 2.328 1.00114.21 N +ATOM 5274 CZ ARG D 47 0.912 52.355 3.187 1.00111.75 C +ATOM 5275 NH1 ARG D 47 1.363 52.855 4.335 1.00109.95 N +ATOM 5276 NH2 ARG D 47 -0.380 52.463 2.892 1.00110.16 N +ATOM 5277 N GLY D 48 7.878 50.648 0.508 1.00 44.75 N +ATOM 5278 CA GLY D 48 8.804 51.730 0.270 1.00 25.19 C +ATOM 5279 C GLY D 48 8.286 52.581 -0.864 1.00 21.16 C +ATOM 5280 O GLY D 48 7.268 52.279 -1.484 1.00 17.92 O +ATOM 5281 N TYR D 49 9.009 53.641 -1.165 1.00 19.53 N +ATOM 5282 CA TYR D 49 8.593 54.546 -2.205 1.00 8.50 C +ATOM 5283 C TYR D 49 9.697 54.719 -3.179 1.00 8.50 C +ATOM 5284 O TYR D 49 10.881 54.479 -2.890 1.00 8.50 O +ATOM 5285 CB TYR D 49 8.301 55.926 -1.621 1.00 8.50 C +ATOM 5286 CG TYR D 49 7.229 55.958 -0.573 1.00 8.50 C +ATOM 5287 CD1 TYR D 49 5.910 55.664 -0.905 1.00 8.50 C +ATOM 5288 CD2 TYR D 49 7.525 56.277 0.744 1.00 8.50 C +ATOM 5289 CE1 TYR D 49 4.911 55.679 0.035 1.00 8.50 C +ATOM 5290 CE2 TYR D 49 6.529 56.297 1.705 1.00 8.50 C +ATOM 5291 CZ TYR D 49 5.220 55.993 1.341 1.00 12.14 C +ATOM 5292 OH TYR D 49 4.211 55.960 2.283 1.00 27.74 O +ATOM 5293 N SER D 50 9.285 55.124 -4.358 1.00 11.93 N +ATOM 5294 CA SER D 50 10.204 55.454 -5.424 1.00 22.26 C +ATOM 5295 C SER D 50 10.633 56.923 -5.230 1.00 28.03 C +ATOM 5296 O SER D 50 9.793 57.812 -5.053 1.00 35.29 O +ATOM 5297 CB SER D 50 9.501 55.306 -6.758 1.00 27.25 C +ATOM 5298 OG SER D 50 10.292 55.857 -7.789 1.00 52.05 O +ATOM 5299 N ILE D 51 11.934 57.169 -5.261 1.00 24.70 N +ATOM 5300 CA ILE D 51 12.454 58.511 -5.083 1.00 12.97 C +ATOM 5301 C ILE D 51 12.681 59.177 -6.442 1.00 16.63 C +ATOM 5302 O ILE D 51 12.159 60.245 -6.695 1.00 22.56 O +ATOM 5303 CB ILE D 51 13.753 58.467 -4.287 1.00 14.11 C +ATOM 5304 CG1 ILE D 51 13.491 57.922 -2.893 1.00 16.65 C +ATOM 5305 CG2 ILE D 51 14.357 59.823 -4.174 1.00 16.73 C +ATOM 5306 CD1 ILE D 51 14.770 57.691 -2.099 1.00 28.05 C +ATOM 5307 N PHE D 52 13.408 58.517 -7.335 1.00 14.27 N +ATOM 5308 CA PHE D 52 13.710 59.055 -8.660 1.00 10.19 C +ATOM 5309 C PHE D 52 13.557 57.944 -9.707 1.00 15.24 C +ATOM 5310 O PHE D 52 14.207 56.908 -9.593 1.00 22.60 O +ATOM 5311 CB PHE D 52 15.151 59.547 -8.658 1.00 8.50 C +ATOM 5312 CG PHE D 52 15.545 60.288 -9.901 1.00 16.44 C +ATOM 5313 CD1 PHE D 52 15.081 61.592 -10.127 1.00 21.39 C +ATOM 5314 CD2 PHE D 52 16.423 59.720 -10.813 1.00 8.50 C +ATOM 5315 CE1 PHE D 52 15.489 62.319 -11.240 1.00 11.89 C +ATOM 5316 CE2 PHE D 52 16.839 60.434 -11.925 1.00 12.47 C +ATOM 5317 CZ PHE D 52 16.375 61.741 -12.144 1.00 17.22 C +ATOM 5318 N SER D 53 12.727 58.155 -10.724 1.00 14.73 N +ATOM 5319 CA SER D 53 12.495 57.148 -11.769 1.00 12.92 C +ATOM 5320 C SER D 53 12.770 57.668 -13.178 1.00 10.50 C +ATOM 5321 O SER D 53 11.997 58.443 -13.711 1.00 11.09 O +ATOM 5322 CB SER D 53 11.053 56.639 -11.707 1.00 13.68 C +ATOM 5323 OG SER D 53 10.854 55.549 -12.590 1.00 24.54 O +ATOM 5324 N TYR D 54 13.860 57.207 -13.781 1.00 13.69 N +ATOM 5325 CA TYR D 54 14.278 57.597 -15.130 1.00 13.34 C +ATOM 5326 C TYR D 54 14.018 56.394 -16.031 1.00 25.93 C +ATOM 5327 O TYR D 54 14.736 55.388 -15.952 1.00 29.91 O +ATOM 5328 CB TYR D 54 15.767 57.899 -15.113 1.00 15.96 C +ATOM 5329 CG TYR D 54 16.356 58.450 -16.393 1.00 22.61 C +ATOM 5330 CD1 TYR D 54 16.797 57.596 -17.409 1.00 17.36 C +ATOM 5331 CD2 TYR D 54 16.578 59.821 -16.544 1.00 18.43 C +ATOM 5332 CE1 TYR D 54 17.460 58.089 -18.537 1.00 8.75 C +ATOM 5333 CE2 TYR D 54 17.229 60.321 -17.663 1.00 19.28 C +ATOM 5334 CZ TYR D 54 17.670 59.447 -18.655 1.00 18.04 C +ATOM 5335 OH TYR D 54 18.304 59.940 -19.765 1.00 12.79 O +ATOM 5336 N ALA D 55 13.013 56.501 -16.896 1.00 31.55 N +ATOM 5337 CA ALA D 55 12.637 55.398 -17.778 1.00 32.67 C +ATOM 5338 C ALA D 55 12.772 55.675 -19.280 1.00 36.35 C +ATOM 5339 O ALA D 55 12.606 56.810 -19.741 1.00 34.80 O +ATOM 5340 CB ALA D 55 11.214 54.947 -17.458 1.00 24.76 C +ATOM 5341 N THR D 56 13.048 54.610 -20.032 1.00 41.52 N +ATOM 5342 CA THR D 56 13.189 54.640 -21.489 1.00 38.81 C +ATOM 5343 C THR D 56 12.104 53.719 -22.055 1.00 45.46 C +ATOM 5344 O THR D 56 11.508 52.900 -21.335 1.00 45.43 O +ATOM 5345 CB THR D 56 14.533 54.033 -21.964 1.00 32.20 C +ATOM 5346 OG1 THR D 56 15.592 54.452 -21.110 1.00 32.68 O +ATOM 5347 CG2 THR D 56 14.852 54.473 -23.376 1.00 36.90 C +ATOM 5348 N LYS D 57 11.872 53.841 -23.354 1.00 51.58 N +ATOM 5349 CA LYS D 57 10.899 53.018 -24.066 1.00 52.79 C +ATOM 5350 C LYS D 57 11.310 51.553 -23.939 1.00 52.13 C +ATOM 5351 O LYS D 57 10.490 50.680 -23.636 1.00 56.86 O +ATOM 5352 CB LYS D 57 10.955 53.398 -25.537 1.00 60.78 C +ATOM 5353 CG LYS D 57 12.390 53.414 -26.082 1.00 66.98 C +ATOM 5354 CD LYS D 57 12.448 53.103 -27.569 1.00 92.79 C +ATOM 5355 CE LYS D 57 11.932 51.668 -27.930 1.00101.27 C +ATOM 5356 NZ LYS D 57 10.459 51.368 -27.701 1.00 93.88 N +ATOM 5357 N ARG D 58 12.605 51.320 -24.140 1.00 47.67 N +ATOM 5358 CA ARG D 58 13.200 49.993 -24.078 1.00 45.91 C +ATOM 5359 C ARG D 58 13.364 49.437 -22.661 1.00 45.09 C +ATOM 5360 O ARG D 58 13.174 48.239 -22.427 1.00 47.56 O +ATOM 5361 CB ARG D 58 14.579 50.032 -24.713 1.00 35.76 C +ATOM 5362 CG ARG D 58 14.713 50.950 -25.910 1.00 44.05 C +ATOM 5363 CD ARG D 58 16.088 50.763 -26.537 1.00 68.31 C +ATOM 5364 NE ARG D 58 17.140 50.693 -25.512 1.00 83.44 N +ATOM 5365 CZ ARG D 58 18.242 49.942 -25.584 1.00 80.35 C +ATOM 5366 NH1 ARG D 58 18.472 49.172 -26.646 1.00 76.08 N +ATOM 5367 NH2 ARG D 58 19.119 49.960 -24.580 1.00 75.23 N +ATOM 5368 N GLN D 59 13.727 50.301 -21.719 1.00 41.45 N +ATOM 5369 CA GLN D 59 13.958 49.881 -20.342 1.00 33.03 C +ATOM 5370 C GLN D 59 13.218 50.822 -19.412 1.00 30.19 C +ATOM 5371 O GLN D 59 13.584 51.984 -19.297 1.00 39.25 O +ATOM 5372 CB GLN D 59 15.468 49.911 -20.073 1.00 24.49 C +ATOM 5373 CG GLN D 59 15.881 49.721 -18.641 1.00 25.78 C +ATOM 5374 CD GLN D 59 15.388 48.432 -18.048 1.00 24.42 C +ATOM 5375 OE1 GLN D 59 14.262 48.350 -17.549 1.00 32.57 O +ATOM 5376 NE2 GLN D 59 16.240 47.424 -18.055 1.00 31.74 N +ATOM 5377 N ASP D 60 12.219 50.308 -18.708 1.00 27.05 N +ATOM 5378 CA ASP D 60 11.427 51.122 -17.791 1.00 30.53 C +ATOM 5379 C ASP D 60 12.207 51.593 -16.537 1.00 28.13 C +ATOM 5380 O ASP D 60 11.888 52.638 -15.935 1.00 30.74 O +ATOM 5381 CB ASP D 60 10.154 50.354 -17.407 1.00 41.36 C +ATOM 5382 CG ASP D 60 10.451 49.027 -16.666 1.00 55.32 C +ATOM 5383 OD1 ASP D 60 11.248 48.205 -17.171 1.00 62.92 O +ATOM 5384 OD2 ASP D 60 9.913 48.819 -15.549 1.00 61.16 O +ATOM 5385 N ASN D 61 13.220 50.825 -16.144 1.00 14.73 N +ATOM 5386 CA ASN D 61 14.017 51.196 -15.001 1.00 9.68 C +ATOM 5387 C ASN D 61 15.451 51.448 -15.421 1.00 9.74 C +ATOM 5388 O ASN D 61 16.358 50.738 -15.003 1.00 11.49 O +ATOM 5389 CB ASN D 61 13.951 50.119 -13.941 1.00 10.85 C +ATOM 5390 CG ASN D 61 12.560 49.971 -13.334 1.00 27.37 C +ATOM 5391 OD1 ASN D 61 12.231 48.914 -12.822 1.00 47.98 O +ATOM 5392 ND2 ASN D 61 11.760 51.021 -13.357 1.00 15.42 N +ATOM 5393 N GLU D 62 15.646 52.476 -16.244 1.00 9.96 N +ATOM 5394 CA GLU D 62 16.968 52.843 -16.739 1.00 9.11 C +ATOM 5395 C GLU D 62 17.874 53.296 -15.603 1.00 8.50 C +ATOM 5396 O GLU D 62 19.043 52.939 -15.556 1.00 14.68 O +ATOM 5397 CB GLU D 62 16.852 53.922 -17.822 1.00 9.37 C +ATOM 5398 CG GLU D 62 18.103 54.113 -18.674 1.00 11.80 C +ATOM 5399 CD GLU D 62 18.421 52.919 -19.558 1.00 20.71 C +ATOM 5400 OE1 GLU D 62 18.571 51.801 -19.035 1.00 32.96 O +ATOM 5401 OE2 GLU D 62 18.531 53.089 -20.788 1.00 32.56 O +ATOM 5402 N ILE D 63 17.357 54.160 -14.747 1.00 9.72 N +ATOM 5403 CA ILE D 63 18.083 54.613 -13.572 1.00 12.10 C +ATOM 5404 C ILE D 63 16.965 54.871 -12.574 1.00 8.50 C +ATOM 5405 O ILE D 63 16.004 55.540 -12.910 1.00 8.50 O +ATOM 5406 CB ILE D 63 19.072 55.842 -13.828 1.00 8.50 C +ATOM 5407 CG1 ILE D 63 18.939 56.886 -12.761 1.00 11.47 C +ATOM 5408 CG2 ILE D 63 18.917 56.461 -15.150 1.00 8.50 C +ATOM 5409 CD1 ILE D 63 19.538 56.453 -11.465 1.00 24.85 C +ATOM 5410 N LEU D 64 17.028 54.208 -11.419 1.00 8.50 N +ATOM 5411 CA LEU D 64 16.006 54.335 -10.389 1.00 8.50 C +ATOM 5412 C LEU D 64 16.554 54.282 -8.969 1.00 10.41 C +ATOM 5413 O LEU D 64 17.359 53.419 -8.648 1.00 14.87 O +ATOM 5414 CB LEU D 64 14.956 53.243 -10.577 1.00 8.56 C +ATOM 5415 CG LEU D 64 13.926 53.008 -9.479 1.00 8.50 C +ATOM 5416 CD1 LEU D 64 12.529 53.364 -9.901 1.00 8.50 C +ATOM 5417 CD2 LEU D 64 13.981 51.553 -9.131 1.00 18.76 C +ATOM 5418 N ILE D 65 16.141 55.243 -8.144 1.00 8.50 N +ATOM 5419 CA ILE D 65 16.540 55.332 -6.744 1.00 9.49 C +ATOM 5420 C ILE D 65 15.293 54.979 -5.942 1.00 13.06 C +ATOM 5421 O ILE D 65 14.255 55.626 -6.064 1.00 8.50 O +ATOM 5422 CB ILE D 65 17.006 56.724 -6.381 1.00 12.97 C +ATOM 5423 CG1 ILE D 65 18.211 57.102 -7.257 1.00 8.50 C +ATOM 5424 CG2 ILE D 65 17.337 56.773 -4.885 1.00 8.50 C +ATOM 5425 CD1 ILE D 65 18.606 58.541 -7.166 1.00 8.50 C +ATOM 5426 N PHE D 66 15.408 53.960 -5.104 1.00 16.02 N +ATOM 5427 CA PHE D 66 14.270 53.467 -4.359 1.00 12.63 C +ATOM 5428 C PHE D 66 14.672 53.219 -2.926 1.00 12.92 C +ATOM 5429 O PHE D 66 15.767 52.715 -2.644 1.00 14.57 O +ATOM 5430 CB PHE D 66 13.821 52.167 -5.020 1.00 22.95 C +ATOM 5431 CG PHE D 66 12.483 51.664 -4.564 1.00 36.12 C +ATOM 5432 CD1 PHE D 66 11.317 52.048 -5.224 1.00 47.67 C +ATOM 5433 CD2 PHE D 66 12.385 50.761 -3.511 1.00 30.41 C +ATOM 5434 CE1 PHE D 66 10.073 51.530 -4.838 1.00 47.37 C +ATOM 5435 CE2 PHE D 66 11.155 50.246 -3.122 1.00 30.56 C +ATOM 5436 CZ PHE D 66 10.000 50.629 -3.784 1.00 37.11 C +ATOM 5437 N TRP D 67 13.829 53.702 -2.025 1.00 8.50 N +ATOM 5438 CA TRP D 67 14.092 53.570 -0.617 1.00 8.50 C +ATOM 5439 C TRP D 67 12.901 52.997 0.137 1.00 18.01 C +ATOM 5440 O TRP D 67 11.760 53.433 -0.021 1.00 15.62 O +ATOM 5441 CB TRP D 67 14.515 54.934 -0.038 1.00 12.75 C +ATOM 5442 CG TRP D 67 14.532 55.006 1.454 1.00 8.50 C +ATOM 5443 CD1 TRP D 67 15.601 54.821 2.275 1.00 10.93 C +ATOM 5444 CD2 TRP D 67 13.408 55.217 2.302 1.00 10.40 C +ATOM 5445 NE1 TRP D 67 15.215 54.890 3.590 1.00 8.50 N +ATOM 5446 CE2 TRP D 67 13.872 55.133 3.639 1.00 8.50 C +ATOM 5447 CE3 TRP D 67 12.043 55.460 2.065 1.00 8.50 C +ATOM 5448 CZ2 TRP D 67 13.027 55.284 4.735 1.00 8.50 C +ATOM 5449 CZ3 TRP D 67 11.199 55.607 3.149 1.00 16.89 C +ATOM 5450 CH2 TRP D 67 11.697 55.520 4.473 1.00 26.90 C +ATOM 5451 N SER D 68 13.189 51.990 0.945 1.00 20.03 N +ATOM 5452 CA SER D 68 12.194 51.353 1.773 1.00 22.76 C +ATOM 5453 C SER D 68 12.845 51.354 3.143 1.00 26.21 C +ATOM 5454 O SER D 68 14.064 51.205 3.241 1.00 21.10 O +ATOM 5455 CB SER D 68 11.947 49.921 1.299 1.00 34.36 C +ATOM 5456 OG SER D 68 11.094 49.218 2.189 1.00 48.80 O +ATOM 5457 N LYS D 69 12.039 51.562 4.183 1.00 30.73 N +ATOM 5458 CA LYS D 69 12.502 51.591 5.579 1.00 29.05 C +ATOM 5459 C LYS D 69 13.421 50.417 5.945 1.00 30.26 C +ATOM 5460 O LYS D 69 14.599 50.609 6.298 1.00 17.83 O +ATOM 5461 CB LYS D 69 11.290 51.577 6.525 1.00 30.11 C +ATOM 5462 CG LYS D 69 11.666 51.510 7.998 1.00 26.89 C +ATOM 5463 CD LYS D 69 10.467 51.212 8.884 1.00 36.74 C +ATOM 5464 CE LYS D 69 10.058 49.740 8.830 1.00 39.90 C +ATOM 5465 NZ LYS D 69 9.209 49.345 10.002 1.00 38.18 N +ATOM 5466 N ASP D 70 12.846 49.210 5.861 1.00 36.94 N +ATOM 5467 CA ASP D 70 13.520 47.941 6.173 1.00 36.65 C +ATOM 5468 C ASP D 70 14.299 47.291 5.024 1.00 31.10 C +ATOM 5469 O ASP D 70 14.370 46.077 4.920 1.00 35.56 O +ATOM 5470 CB ASP D 70 12.531 46.927 6.798 1.00 44.87 C +ATOM 5471 CG ASP D 70 11.177 46.880 6.086 1.00 51.90 C +ATOM 5472 OD1 ASP D 70 11.125 47.045 4.845 1.00 60.11 O +ATOM 5473 OD2 ASP D 70 10.160 46.665 6.783 1.00 50.03 O +ATOM 5474 N ILE D 71 14.923 48.122 4.200 1.00 37.39 N +ATOM 5475 CA ILE D 71 15.726 47.680 3.058 1.00 29.10 C +ATOM 5476 C ILE D 71 16.956 48.586 2.910 1.00 27.78 C +ATOM 5477 O ILE D 71 18.099 48.104 2.857 1.00 21.00 O +ATOM 5478 CB ILE D 71 14.918 47.754 1.757 1.00 28.11 C +ATOM 5479 CG1 ILE D 71 13.826 46.694 1.784 1.00 18.59 C +ATOM 5480 CG2 ILE D 71 15.840 47.638 0.539 1.00 16.69 C +ATOM 5481 CD1 ILE D 71 13.103 46.570 0.498 1.00 32.72 C +ATOM 5482 N GLY D 72 16.694 49.896 2.863 1.00 25.17 N +ATOM 5483 CA GLY D 72 17.738 50.892 2.731 1.00 10.84 C +ATOM 5484 C GLY D 72 17.593 51.467 1.360 1.00 8.50 C +ATOM 5485 O GLY D 72 16.476 51.545 0.845 1.00 8.50 O +ATOM 5486 N TYR D 73 18.717 51.831 0.751 1.00 10.32 N +ATOM 5487 CA TYR D 73 18.681 52.399 -0.587 1.00 8.50 C +ATOM 5488 C TYR D 73 18.957 51.394 -1.664 1.00 8.50 C +ATOM 5489 O TYR D 73 19.950 50.671 -1.615 1.00 14.29 O +ATOM 5490 CB TYR D 73 19.644 53.570 -0.700 1.00 8.50 C +ATOM 5491 CG TYR D 73 19.246 54.719 0.194 1.00 18.84 C +ATOM 5492 CD1 TYR D 73 18.151 55.541 -0.136 1.00 10.54 C +ATOM 5493 CD2 TYR D 73 19.917 54.954 1.402 1.00 10.45 C +ATOM 5494 CE1 TYR D 73 17.737 56.549 0.712 1.00 8.50 C +ATOM 5495 CE2 TYR D 73 19.508 55.960 2.244 1.00 11.30 C +ATOM 5496 CZ TYR D 73 18.420 56.752 1.897 1.00 11.36 C +ATOM 5497 OH TYR D 73 18.023 57.767 2.726 1.00 29.61 O +ATOM 5498 N SER D 74 18.078 51.380 -2.650 1.00 8.50 N +ATOM 5499 CA SER D 74 18.161 50.479 -3.769 1.00 8.50 C +ATOM 5500 C SER D 74 18.436 51.286 -5.012 1.00 8.50 C +ATOM 5501 O SER D 74 17.538 51.917 -5.546 1.00 8.50 O +ATOM 5502 CB SER D 74 16.833 49.759 -3.916 1.00 8.50 C +ATOM 5503 OG SER D 74 16.782 49.047 -5.129 1.00 33.74 O +ATOM 5504 N PHE D 75 19.684 51.269 -5.459 1.00 8.50 N +ATOM 5505 CA PHE D 75 20.080 52.006 -6.640 1.00 8.50 C +ATOM 5506 C PHE D 75 20.182 51.068 -7.821 1.00 8.50 C +ATOM 5507 O PHE D 75 21.036 50.207 -7.847 1.00 8.50 O +ATOM 5508 CB PHE D 75 21.428 52.691 -6.408 1.00 19.60 C +ATOM 5509 CG PHE D 75 21.934 53.475 -7.604 1.00 20.56 C +ATOM 5510 CD1 PHE D 75 21.239 54.587 -8.067 1.00 14.38 C +ATOM 5511 CD2 PHE D 75 23.079 53.077 -8.286 1.00 11.24 C +ATOM 5512 CE1 PHE D 75 21.668 55.267 -9.177 1.00 8.50 C +ATOM 5513 CE2 PHE D 75 23.504 53.767 -9.399 1.00 8.50 C +ATOM 5514 CZ PHE D 75 22.798 54.857 -9.843 1.00 8.50 C +ATOM 5515 N THR D 76 19.347 51.284 -8.824 1.00 10.97 N +ATOM 5516 CA THR D 76 19.326 50.446 -10.015 1.00 11.13 C +ATOM 5517 C THR D 76 19.512 51.210 -11.332 1.00 8.50 C +ATOM 5518 O THR D 76 18.872 52.221 -11.576 1.00 11.96 O +ATOM 5519 CB THR D 76 18.016 49.554 -10.041 1.00 16.48 C +ATOM 5520 OG1 THR D 76 17.496 49.438 -11.376 1.00 13.52 O +ATOM 5521 CG2 THR D 76 16.936 50.106 -9.094 1.00 8.98 C +ATOM 5522 N VAL D 77 20.441 50.759 -12.150 1.00 8.50 N +ATOM 5523 CA VAL D 77 20.686 51.388 -13.429 1.00 12.08 C +ATOM 5524 C VAL D 77 20.730 50.307 -14.495 1.00 20.47 C +ATOM 5525 O VAL D 77 21.437 49.322 -14.358 1.00 26.19 O +ATOM 5526 CB VAL D 77 22.002 52.238 -13.444 1.00 13.14 C +ATOM 5527 CG1 VAL D 77 23.070 51.621 -12.578 1.00 10.28 C +ATOM 5528 CG2 VAL D 77 22.534 52.384 -14.854 1.00 14.30 C +ATOM 5529 N GLY D 78 19.909 50.464 -15.522 1.00 20.82 N +ATOM 5530 CA GLY D 78 19.861 49.501 -16.595 1.00 14.67 C +ATOM 5531 C GLY D 78 19.187 48.212 -16.154 1.00 21.72 C +ATOM 5532 O GLY D 78 19.587 47.126 -16.565 1.00 35.14 O +ATOM 5533 N GLY D 79 18.172 48.310 -15.308 1.00 19.92 N +ATOM 5534 CA GLY D 79 17.472 47.113 -14.865 1.00 18.19 C +ATOM 5535 C GLY D 79 18.189 46.292 -13.811 1.00 19.06 C +ATOM 5536 O GLY D 79 17.579 45.409 -13.197 1.00 18.37 O +ATOM 5537 N SER D 80 19.475 46.565 -13.603 1.00 19.19 N +ATOM 5538 CA SER D 80 20.264 45.857 -12.592 1.00 22.32 C +ATOM 5539 C SER D 80 20.361 46.658 -11.274 1.00 21.33 C +ATOM 5540 O SER D 80 20.808 47.801 -11.255 1.00 30.20 O +ATOM 5541 CB SER D 80 21.650 45.526 -13.142 1.00 15.88 C +ATOM 5542 OG SER D 80 21.555 44.621 -14.220 1.00 21.20 O +ATOM 5543 N GLU D 81 19.950 46.025 -10.184 1.00 13.66 N +ATOM 5544 CA GLU D 81 19.915 46.606 -8.859 1.00 8.50 C +ATOM 5545 C GLU D 81 21.170 46.380 -8.037 1.00 10.04 C +ATOM 5546 O GLU D 81 21.960 45.488 -8.308 1.00 16.84 O +ATOM 5547 CB GLU D 81 18.701 46.037 -8.140 1.00 8.50 C +ATOM 5548 CG GLU D 81 18.455 46.484 -6.730 1.00 9.79 C +ATOM 5549 CD GLU D 81 17.396 45.623 -6.033 1.00 31.70 C +ATOM 5550 OE1 GLU D 81 17.646 44.408 -5.845 1.00 45.77 O +ATOM 5551 OE2 GLU D 81 16.316 46.146 -5.666 1.00 33.36 O +ATOM 5552 N ILE D 82 21.345 47.225 -7.027 1.00 17.12 N +ATOM 5553 CA ILE D 82 22.483 47.182 -6.101 1.00 11.82 C +ATOM 5554 C ILE D 82 21.967 47.796 -4.792 1.00 8.50 C +ATOM 5555 O ILE D 82 21.083 48.652 -4.796 1.00 8.50 O +ATOM 5556 CB ILE D 82 23.702 47.940 -6.666 1.00 8.50 C +ATOM 5557 CG1 ILE D 82 24.974 47.380 -6.074 1.00 9.81 C +ATOM 5558 CG2 ILE D 82 23.617 49.419 -6.359 1.00 15.81 C +ATOM 5559 CD1 ILE D 82 26.186 47.826 -6.823 1.00 23.59 C +ATOM 5560 N LEU D 83 22.484 47.343 -3.669 1.00 8.50 N +ATOM 5561 CA LEU D 83 21.965 47.830 -2.412 1.00 8.50 C +ATOM 5562 C LEU D 83 22.935 48.558 -1.512 1.00 14.58 C +ATOM 5563 O LEU D 83 24.110 48.173 -1.385 1.00 18.10 O +ATOM 5564 CB LEU D 83 21.318 46.674 -1.642 1.00 14.51 C +ATOM 5565 CG LEU D 83 19.798 46.468 -1.671 1.00 8.50 C +ATOM 5566 CD1 LEU D 83 19.274 46.560 -3.063 1.00 22.69 C +ATOM 5567 CD2 LEU D 83 19.471 45.108 -1.105 1.00 22.63 C +ATOM 5568 N PHE D 84 22.419 49.635 -0.917 1.00 12.92 N +ATOM 5569 CA PHE D 84 23.132 50.477 0.032 1.00 8.50 C +ATOM 5570 C PHE D 84 22.152 50.604 1.152 1.00 8.50 C +ATOM 5571 O PHE D 84 21.128 51.226 0.981 1.00 8.50 O +ATOM 5572 CB PHE D 84 23.324 51.868 -0.508 1.00 8.50 C +ATOM 5573 CG PHE D 84 24.234 51.935 -1.647 1.00 8.50 C +ATOM 5574 CD1 PHE D 84 25.598 51.887 -1.442 1.00 8.50 C +ATOM 5575 CD2 PHE D 84 23.735 52.068 -2.940 1.00 8.50 C +ATOM 5576 CE1 PHE D 84 26.464 51.974 -2.504 1.00 8.50 C +ATOM 5577 CE2 PHE D 84 24.589 52.153 -4.012 1.00 8.50 C +ATOM 5578 CZ PHE D 84 25.958 52.108 -3.798 1.00 8.50 C +ATOM 5579 N GLU D 85 22.427 49.979 2.282 1.00 11.22 N +ATOM 5580 CA GLU D 85 21.523 50.086 3.408 1.00 19.74 C +ATOM 5581 C GLU D 85 22.150 51.022 4.430 1.00 20.22 C +ATOM 5582 O GLU D 85 23.362 50.991 4.658 1.00 11.19 O +ATOM 5583 CB GLU D 85 21.257 48.714 4.039 1.00 40.29 C +ATOM 5584 CG GLU D 85 22.449 48.077 4.773 1.00 54.61 C +ATOM 5585 CD GLU D 85 22.986 46.825 4.089 1.00 65.60 C +ATOM 5586 OE1 GLU D 85 22.193 46.086 3.451 1.00 63.52 O +ATOM 5587 OE2 GLU D 85 24.210 46.580 4.203 1.00 78.45 O +ATOM 5588 N VAL D 86 21.335 51.895 4.999 1.00 29.20 N +ATOM 5589 CA VAL D 86 21.828 52.830 5.999 1.00 46.83 C +ATOM 5590 C VAL D 86 21.268 52.409 7.353 1.00 55.23 C +ATOM 5591 O VAL D 86 20.056 52.257 7.526 1.00 59.72 O +ATOM 5592 CB VAL D 86 21.488 54.302 5.653 1.00 49.49 C +ATOM 5593 CG1 VAL D 86 22.288 54.739 4.414 1.00 33.43 C +ATOM 5594 CG2 VAL D 86 19.973 54.471 5.445 1.00 56.39 C +ATOM 5595 N PRO D 87 22.167 52.182 8.322 1.00 56.79 N +ATOM 5596 CA PRO D 87 21.891 51.756 9.693 1.00 64.82 C +ATOM 5597 C PRO D 87 20.918 52.589 10.524 1.00 77.57 C +ATOM 5598 O PRO D 87 19.731 52.262 10.614 1.00 84.52 O +ATOM 5599 CB PRO D 87 23.291 51.713 10.311 1.00 67.74 C +ATOM 5600 CG PRO D 87 24.031 52.764 9.555 1.00 59.00 C +ATOM 5601 CD PRO D 87 23.599 52.470 8.152 1.00 59.55 C +ATOM 5602 N GLU D 88 21.432 53.629 11.179 1.00 84.60 N +ATOM 5603 CA GLU D 88 20.607 54.476 12.027 1.00 88.20 C +ATOM 5604 C GLU D 88 19.546 55.221 11.241 1.00 86.13 C +ATOM 5605 O GLU D 88 19.857 55.992 10.328 1.00 84.57 O +ATOM 5606 CB GLU D 88 21.464 55.486 12.792 1.00 92.93 C +ATOM 5607 CG GLU D 88 20.646 56.396 13.706 1.00 99.78 C +ATOM 5608 CD GLU D 88 21.272 57.760 13.895 1.00100.82 C +ATOM 5609 OE1 GLU D 88 22.379 57.830 14.473 1.00105.07 O +ATOM 5610 OE2 GLU D 88 20.655 58.760 13.464 1.00 92.74 O +ATOM 5611 N VAL D 89 18.293 55.000 11.616 1.00 84.49 N +ATOM 5612 CA VAL D 89 17.191 55.672 10.954 1.00 89.93 C +ATOM 5613 C VAL D 89 16.885 57.020 11.632 1.00 87.89 C +ATOM 5614 O VAL D 89 16.347 57.085 12.747 1.00 83.52 O +ATOM 5615 CB VAL D 89 15.928 54.752 10.847 1.00 98.60 C +ATOM 5616 CG1 VAL D 89 15.249 54.548 12.222 1.00101.44 C +ATOM 5617 CG2 VAL D 89 14.958 55.301 9.793 1.00 95.72 C +ATOM 5618 N THR D 90 17.328 58.089 10.976 1.00 85.75 N +ATOM 5619 CA THR D 90 17.116 59.443 11.459 1.00 77.02 C +ATOM 5620 C THR D 90 15.819 59.949 10.824 1.00 72.03 C +ATOM 5621 O THR D 90 15.615 59.809 9.604 1.00 68.21 O +ATOM 5622 CB THR D 90 18.318 60.364 11.086 1.00 76.95 C +ATOM 5623 OG1 THR D 90 18.226 61.606 11.798 1.00 83.39 O +ATOM 5624 CG2 THR D 90 18.349 60.646 9.589 1.00 76.08 C +ATOM 5625 N VAL D 91 14.905 60.429 11.669 1.00 64.36 N +ATOM 5626 CA VAL D 91 13.632 60.952 11.194 1.00 55.11 C +ATOM 5627 C VAL D 91 13.806 62.452 10.977 1.00 43.71 C +ATOM 5628 O VAL D 91 13.656 63.265 11.891 1.00 39.82 O +ATOM 5629 CB VAL D 91 12.475 60.614 12.160 1.00 56.84 C +ATOM 5630 CG1 VAL D 91 12.745 61.182 13.548 1.00 63.93 C +ATOM 5631 CG2 VAL D 91 11.149 61.091 11.581 1.00 61.67 C +ATOM 5632 N ALA D 92 14.188 62.779 9.744 1.00 38.74 N +ATOM 5633 CA ALA D 92 14.466 64.140 9.290 1.00 26.27 C +ATOM 5634 C ALA D 92 14.676 64.112 7.763 1.00 23.46 C +ATOM 5635 O ALA D 92 14.681 63.051 7.142 1.00 40.90 O +ATOM 5636 CB ALA D 92 15.755 64.649 9.977 1.00 8.50 C +ATOM 5637 N PRO D 93 14.739 65.280 7.127 1.00 10.86 N +ATOM 5638 CA PRO D 93 14.955 65.374 5.692 1.00 8.50 C +ATOM 5639 C PRO D 93 16.314 64.758 5.437 1.00 9.42 C +ATOM 5640 O PRO D 93 17.188 64.778 6.315 1.00 16.27 O +ATOM 5641 CB PRO D 93 14.996 66.869 5.472 1.00 8.50 C +ATOM 5642 CG PRO D 93 14.053 67.371 6.469 1.00 8.50 C +ATOM 5643 CD PRO D 93 14.431 66.602 7.684 1.00 22.10 C +ATOM 5644 N VAL D 94 16.484 64.180 4.256 1.00 9.60 N +ATOM 5645 CA VAL D 94 17.738 63.546 3.904 1.00 8.50 C +ATOM 5646 C VAL D 94 18.135 64.006 2.514 1.00 8.50 C +ATOM 5647 O VAL D 94 17.280 64.330 1.693 1.00 8.50 O +ATOM 5648 CB VAL D 94 17.622 61.993 4.064 1.00 8.50 C +ATOM 5649 CG1 VAL D 94 16.263 61.506 3.629 1.00 24.68 C +ATOM 5650 CG2 VAL D 94 18.672 61.274 3.285 1.00 13.03 C +ATOM 5651 N HIS D 95 19.434 64.151 2.295 1.00 8.50 N +ATOM 5652 CA HIS D 95 19.960 64.597 1.010 1.00 8.50 C +ATOM 5653 C HIS D 95 20.851 63.526 0.455 1.00 8.50 C +ATOM 5654 O HIS D 95 21.787 63.111 1.131 1.00 9.86 O +ATOM 5655 CB HIS D 95 20.781 65.877 1.219 1.00 16.24 C +ATOM 5656 CG HIS D 95 21.586 66.313 0.029 1.00 8.50 C +ATOM 5657 ND1 HIS D 95 21.086 67.142 -0.951 1.00 8.50 N +ATOM 5658 CD2 HIS D 95 22.867 66.049 -0.320 1.00 8.50 C +ATOM 5659 CE1 HIS D 95 22.022 67.365 -1.853 1.00 8.50 C +ATOM 5660 NE2 HIS D 95 23.110 66.714 -1.493 1.00 8.50 N +ATOM 5661 N ILE D 96 20.591 63.100 -0.780 1.00 9.55 N +ATOM 5662 CA ILE D 96 21.415 62.069 -1.410 1.00 10.56 C +ATOM 5663 C ILE D 96 21.960 62.503 -2.768 1.00 8.50 C +ATOM 5664 O ILE D 96 21.364 63.321 -3.455 1.00 8.50 O +ATOM 5665 CB ILE D 96 20.644 60.731 -1.598 1.00 8.50 C +ATOM 5666 CG1 ILE D 96 19.410 60.960 -2.446 1.00 11.23 C +ATOM 5667 CG2 ILE D 96 20.210 60.147 -0.262 1.00 11.22 C +ATOM 5668 CD1 ILE D 96 18.777 59.692 -2.908 1.00 17.04 C +ATOM 5669 N CYS D 97 23.156 62.030 -3.081 1.00 8.50 N +ATOM 5670 CA CYS D 97 23.794 62.286 -4.360 1.00 8.96 C +ATOM 5671 C CYS D 97 24.294 60.911 -4.736 1.00 8.50 C +ATOM 5672 O CYS D 97 24.896 60.235 -3.908 1.00 8.50 O +ATOM 5673 CB CYS D 97 25.016 63.194 -4.234 1.00 19.10 C +ATOM 5674 SG CYS D 97 24.786 64.992 -4.291 1.00 8.50 S +ATOM 5675 N THR D 98 24.048 60.499 -5.969 1.00 8.50 N +ATOM 5676 CA THR D 98 24.488 59.192 -6.423 1.00 9.45 C +ATOM 5677 C THR D 98 25.054 59.335 -7.813 1.00 9.97 C +ATOM 5678 O THR D 98 24.570 60.184 -8.573 1.00 18.45 O +ATOM 5679 CB THR D 98 23.333 58.192 -6.401 1.00 17.42 C +ATOM 5680 OG1 THR D 98 23.810 56.897 -6.792 1.00 26.17 O +ATOM 5681 CG2 THR D 98 22.195 58.648 -7.304 1.00 8.50 C +ATOM 5682 N SER D 99 26.100 58.566 -8.126 1.00 8.50 N +ATOM 5683 CA SER D 99 26.747 58.653 -9.437 1.00 11.74 C +ATOM 5684 C SER D 99 27.186 57.322 -10.018 1.00 11.91 C +ATOM 5685 O SER D 99 27.477 56.398 -9.282 1.00 18.12 O +ATOM 5686 CB SER D 99 27.936 59.626 -9.390 1.00 20.22 C +ATOM 5687 OG SER D 99 28.833 59.379 -8.311 1.00 8.50 O +ATOM 5688 N TRP D 100 27.250 57.241 -11.343 1.00 14.05 N +ATOM 5689 CA TRP D 100 27.638 56.015 -12.044 1.00 12.58 C +ATOM 5690 C TRP D 100 28.532 56.361 -13.242 1.00 11.62 C +ATOM 5691 O TRP D 100 28.362 57.394 -13.888 1.00 14.48 O +ATOM 5692 CB TRP D 100 26.373 55.263 -12.502 1.00 17.43 C +ATOM 5693 CG TRP D 100 26.616 54.180 -13.511 1.00 18.55 C +ATOM 5694 CD1 TRP D 100 27.028 52.907 -13.262 1.00 25.27 C +ATOM 5695 CD2 TRP D 100 26.459 54.277 -14.933 1.00 20.73 C +ATOM 5696 NE1 TRP D 100 27.138 52.203 -14.436 1.00 19.98 N +ATOM 5697 CE2 TRP D 100 26.796 53.023 -15.476 1.00 14.87 C +ATOM 5698 CE3 TRP D 100 26.067 55.308 -15.802 1.00 19.19 C +ATOM 5699 CZ2 TRP D 100 26.753 52.770 -16.838 1.00 14.28 C +ATOM 5700 CZ3 TRP D 100 26.024 55.051 -17.160 1.00 13.22 C +ATOM 5701 CH2 TRP D 100 26.365 53.794 -17.662 1.00 13.91 C +ATOM 5702 N GLU D 101 29.465 55.475 -13.548 1.00 11.25 N +ATOM 5703 CA GLU D 101 30.405 55.678 -14.636 1.00 13.61 C +ATOM 5704 C GLU D 101 30.481 54.404 -15.472 1.00 17.16 C +ATOM 5705 O GLU D 101 30.913 53.371 -14.977 1.00 17.53 O +ATOM 5706 CB GLU D 101 31.783 55.997 -14.043 1.00 8.50 C +ATOM 5707 CG GLU D 101 32.873 56.140 -15.044 1.00 10.41 C +ATOM 5708 CD GLU D 101 34.215 56.390 -14.413 1.00 15.42 C +ATOM 5709 OE1 GLU D 101 34.795 55.446 -13.857 1.00 20.39 O +ATOM 5710 OE2 GLU D 101 34.714 57.530 -14.485 1.00 35.63 O +ATOM 5711 N SER D 102 30.096 54.483 -16.741 1.00 16.92 N +ATOM 5712 CA SER D 102 30.139 53.314 -17.610 1.00 16.95 C +ATOM 5713 C SER D 102 31.538 52.701 -17.680 1.00 16.90 C +ATOM 5714 O SER D 102 31.715 51.491 -17.537 1.00 22.20 O +ATOM 5715 CB SER D 102 29.663 53.672 -19.025 1.00 17.04 C +ATOM 5716 OG SER D 102 29.949 52.645 -19.975 1.00 9.72 O +ATOM 5717 N ALA D 103 32.538 53.548 -17.853 1.00 15.22 N +ATOM 5718 CA ALA D 103 33.917 53.093 -17.975 1.00 16.33 C +ATOM 5719 C ALA D 103 34.453 52.129 -16.920 1.00 15.28 C +ATOM 5720 O ALA D 103 35.369 51.366 -17.212 1.00 28.46 O +ATOM 5721 CB ALA D 103 34.861 54.296 -18.116 1.00 17.77 C +ATOM 5722 N SER D 104 33.914 52.155 -15.706 1.00 12.18 N +ATOM 5723 CA SER D 104 34.420 51.267 -14.649 1.00 9.57 C +ATOM 5724 C SER D 104 33.303 50.553 -13.894 1.00 9.79 C +ATOM 5725 O SER D 104 33.528 49.539 -13.222 1.00 8.50 O +ATOM 5726 CB SER D 104 35.243 52.080 -13.657 1.00 8.50 C +ATOM 5727 OG SER D 104 34.388 52.982 -12.962 1.00 13.52 O +ATOM 5728 N GLY D 105 32.103 51.111 -13.997 1.00 11.28 N +ATOM 5729 CA GLY D 105 30.958 50.548 -13.327 1.00 9.07 C +ATOM 5730 C GLY D 105 30.912 51.030 -11.902 1.00 14.79 C +ATOM 5731 O GLY D 105 30.021 50.633 -11.164 1.00 26.01 O +ATOM 5732 N ILE D 106 31.842 51.895 -11.503 1.00 8.50 N +ATOM 5733 CA ILE D 106 31.832 52.382 -10.141 1.00 8.50 C +ATOM 5734 C ILE D 106 30.683 53.331 -9.856 1.00 9.50 C +ATOM 5735 O ILE D 106 30.524 54.354 -10.522 1.00 15.02 O +ATOM 5736 CB ILE D 106 33.121 53.065 -9.768 1.00 8.50 C +ATOM 5737 CG1 ILE D 106 34.257 52.065 -9.798 1.00 8.50 C +ATOM 5738 CG2 ILE D 106 33.019 53.605 -8.363 1.00 8.50 C +ATOM 5739 CD1 ILE D 106 35.587 52.643 -9.398 1.00 8.50 C +ATOM 5740 N VAL D 107 29.879 52.976 -8.862 1.00 10.20 N +ATOM 5741 CA VAL D 107 28.748 53.789 -8.436 1.00 10.84 C +ATOM 5742 C VAL D 107 28.999 54.230 -6.980 1.00 9.22 C +ATOM 5743 O VAL D 107 29.446 53.434 -6.168 1.00 13.11 O +ATOM 5744 CB VAL D 107 27.383 53.027 -8.601 1.00 8.50 C +ATOM 5745 CG1 VAL D 107 27.516 51.607 -8.207 1.00 9.66 C +ATOM 5746 CG2 VAL D 107 26.322 53.641 -7.742 1.00 9.44 C +ATOM 5747 N GLU D 108 28.830 55.522 -6.696 1.00 13.22 N +ATOM 5748 CA GLU D 108 29.020 56.091 -5.352 1.00 8.50 C +ATOM 5749 C GLU D 108 27.636 56.485 -4.861 1.00 8.50 C +ATOM 5750 O GLU D 108 26.761 56.829 -5.660 1.00 9.80 O +ATOM 5751 CB GLU D 108 29.861 57.379 -5.393 1.00 8.50 C +ATOM 5752 CG GLU D 108 31.291 57.283 -5.920 1.00 8.50 C +ATOM 5753 CD GLU D 108 31.942 58.672 -6.168 1.00 28.12 C +ATOM 5754 OE1 GLU D 108 31.263 59.730 -6.048 1.00 31.61 O +ATOM 5755 OE2 GLU D 108 33.147 58.720 -6.514 1.00 26.79 O +ATOM 5756 N PHE D 109 27.420 56.435 -3.559 1.00 9.13 N +ATOM 5757 CA PHE D 109 26.144 56.847 -3.002 1.00 8.50 C +ATOM 5758 C PHE D 109 26.540 57.656 -1.798 1.00 8.95 C +ATOM 5759 O PHE D 109 27.272 57.164 -0.939 1.00 11.00 O +ATOM 5760 CB PHE D 109 25.333 55.664 -2.564 1.00 8.50 C +ATOM 5761 CG PHE D 109 23.879 55.917 -2.524 1.00 8.50 C +ATOM 5762 CD1 PHE D 109 23.110 55.758 -3.659 1.00 8.50 C +ATOM 5763 CD2 PHE D 109 23.262 56.274 -1.355 1.00 8.50 C +ATOM 5764 CE1 PHE D 109 21.742 55.950 -3.631 1.00 8.50 C +ATOM 5765 CE2 PHE D 109 21.896 56.471 -1.311 1.00 8.50 C +ATOM 5766 CZ PHE D 109 21.134 56.309 -2.455 1.00 8.50 C +ATOM 5767 N TRP D 110 26.173 58.932 -1.802 1.00 10.39 N +ATOM 5768 CA TRP D 110 26.480 59.835 -0.707 1.00 8.91 C +ATOM 5769 C TRP D 110 25.185 60.195 0.023 1.00 9.60 C +ATOM 5770 O TRP D 110 24.255 60.740 -0.580 1.00 8.50 O +ATOM 5771 CB TRP D 110 27.098 61.124 -1.235 1.00 8.50 C +ATOM 5772 CG TRP D 110 28.359 60.964 -1.921 1.00 8.50 C +ATOM 5773 CD1 TRP D 110 28.549 60.400 -3.126 1.00 8.50 C +ATOM 5774 CD2 TRP D 110 29.642 61.392 -1.466 1.00 8.50 C +ATOM 5775 NE1 TRP D 110 29.876 60.440 -3.466 1.00 10.68 N +ATOM 5776 CE2 TRP D 110 30.571 61.046 -2.458 1.00 8.50 C +ATOM 5777 CE3 TRP D 110 30.094 62.033 -0.317 1.00 8.50 C +ATOM 5778 CZ2 TRP D 110 31.936 61.316 -2.344 1.00 8.81 C +ATOM 5779 CZ3 TRP D 110 31.458 62.309 -0.197 1.00 11.50 C +ATOM 5780 CH2 TRP D 110 32.360 61.948 -1.207 1.00 8.50 C +ATOM 5781 N VAL D 111 25.125 59.907 1.315 1.00 8.50 N +ATOM 5782 CA VAL D 111 23.956 60.256 2.088 1.00 8.50 C +ATOM 5783 C VAL D 111 24.367 61.337 3.096 1.00 14.92 C +ATOM 5784 O VAL D 111 25.296 61.151 3.887 1.00 16.18 O +ATOM 5785 CB VAL D 111 23.379 59.061 2.819 1.00 8.50 C +ATOM 5786 CG1 VAL D 111 22.142 59.467 3.577 1.00 8.50 C +ATOM 5787 CG2 VAL D 111 23.044 57.974 1.835 1.00 16.21 C +ATOM 5788 N ASP D 112 23.702 62.487 3.013 1.00 12.63 N +ATOM 5789 CA ASP D 112 23.963 63.622 3.878 1.00 8.50 C +ATOM 5790 C ASP D 112 25.406 64.087 3.882 1.00 8.50 C +ATOM 5791 O ASP D 112 25.951 64.416 4.924 1.00 8.50 O +ATOM 5792 CB ASP D 112 23.482 63.365 5.294 1.00 8.50 C +ATOM 5793 CG ASP D 112 21.994 63.611 5.464 1.00 8.94 C +ATOM 5794 OD1 ASP D 112 21.442 64.477 4.765 1.00 8.50 O +ATOM 5795 OD2 ASP D 112 21.373 62.950 6.329 1.00 17.38 O +ATOM 5796 N GLY D 113 26.011 64.130 2.699 1.00 8.50 N +ATOM 5797 CA GLY D 113 27.371 64.609 2.575 1.00 8.50 C +ATOM 5798 C GLY D 113 28.453 63.614 2.896 1.00 14.33 C +ATOM 5799 O GLY D 113 29.636 63.924 2.682 1.00 17.56 O +ATOM 5800 N LYS D 114 28.066 62.449 3.433 1.00 13.82 N +ATOM 5801 CA LYS D 114 29.027 61.397 3.772 1.00 9.23 C +ATOM 5802 C LYS D 114 28.878 60.217 2.807 1.00 9.63 C +ATOM 5803 O LYS D 114 27.777 59.734 2.547 1.00 10.53 O +ATOM 5804 CB LYS D 114 28.972 61.024 5.256 1.00 8.50 C +ATOM 5805 CG LYS D 114 29.562 62.135 6.132 1.00 33.03 C +ATOM 5806 CD LYS D 114 30.266 61.637 7.412 1.00 59.88 C +ATOM 5807 CE LYS D 114 31.031 62.786 8.141 1.00 62.71 C +ATOM 5808 NZ LYS D 114 31.992 62.345 9.226 1.00 27.71 N +ATOM 5809 N PRO D 115 30.002 59.764 2.236 1.00 8.50 N +ATOM 5810 CA PRO D 115 30.053 58.672 1.284 1.00 8.50 C +ATOM 5811 C PRO D 115 29.940 57.276 1.818 1.00 8.50 C +ATOM 5812 O PRO D 115 30.506 56.960 2.847 1.00 8.50 O +ATOM 5813 CB PRO D 115 31.433 58.864 0.671 1.00 11.89 C +ATOM 5814 CG PRO D 115 32.242 59.196 1.849 1.00 8.50 C +ATOM 5815 CD PRO D 115 31.367 60.206 2.570 1.00 12.85 C +ATOM 5816 N ARG D 116 29.234 56.438 1.066 1.00 10.37 N +ATOM 5817 CA ARG D 116 29.106 55.025 1.359 1.00 8.50 C +ATOM 5818 C ARG D 116 30.229 54.445 0.480 1.00 12.24 C +ATOM 5819 O ARG D 116 30.742 55.137 -0.402 1.00 14.74 O +ATOM 5820 CB ARG D 116 27.765 54.523 0.877 1.00 8.50 C +ATOM 5821 CG ARG D 116 26.596 55.267 1.455 1.00 8.62 C +ATOM 5822 CD ARG D 116 26.342 54.895 2.902 1.00 30.83 C +ATOM 5823 NE ARG D 116 25.697 53.591 3.034 1.00 41.98 N +ATOM 5824 CZ ARG D 116 26.340 52.468 3.334 1.00 49.74 C +ATOM 5825 NH1 ARG D 116 27.656 52.490 3.536 1.00 44.21 N +ATOM 5826 NH2 ARG D 116 25.673 51.314 3.393 1.00 52.60 N +ATOM 5827 N VAL D 117 30.597 53.185 0.681 1.00 14.51 N +ATOM 5828 CA VAL D 117 31.675 52.592 -0.106 1.00 10.77 C +ATOM 5829 C VAL D 117 31.332 52.551 -1.596 1.00 15.98 C +ATOM 5830 O VAL D 117 30.162 52.677 -1.971 1.00 18.97 O +ATOM 5831 CB VAL D 117 32.017 51.174 0.355 1.00 8.50 C +ATOM 5832 CG1 VAL D 117 33.439 50.877 -0.027 1.00 17.86 C +ATOM 5833 CG2 VAL D 117 31.855 51.030 1.837 1.00 8.50 C +ATOM 5834 N ARG D 118 32.357 52.426 -2.442 1.00 15.65 N +ATOM 5835 CA ARG D 118 32.156 52.369 -3.887 1.00 9.08 C +ATOM 5836 C ARG D 118 31.840 50.938 -4.323 1.00 11.22 C +ATOM 5837 O ARG D 118 32.479 49.982 -3.883 1.00 14.49 O +ATOM 5838 CB ARG D 118 33.386 52.852 -4.627 1.00 8.50 C +ATOM 5839 CG ARG D 118 33.845 54.209 -4.264 1.00 8.50 C +ATOM 5840 CD ARG D 118 34.837 54.674 -5.289 1.00 16.94 C +ATOM 5841 NE ARG D 118 35.867 55.530 -4.719 1.00 13.56 N +ATOM 5842 CZ ARG D 118 35.963 56.836 -4.937 1.00 12.93 C +ATOM 5843 NH1 ARG D 118 35.096 57.463 -5.718 1.00 10.93 N +ATOM 5844 NH2 ARG D 118 36.949 57.511 -4.395 1.00 8.50 N +ATOM 5845 N LYS D 119 30.861 50.798 -5.202 1.00 9.39 N +ATOM 5846 CA LYS D 119 30.450 49.504 -5.689 1.00 8.50 C +ATOM 5847 C LYS D 119 30.496 49.465 -7.215 1.00 11.87 C +ATOM 5848 O LYS D 119 30.629 50.503 -7.849 1.00 14.13 O +ATOM 5849 CB LYS D 119 29.055 49.187 -5.156 1.00 8.50 C +ATOM 5850 CG LYS D 119 29.037 49.017 -3.657 1.00 8.50 C +ATOM 5851 CD LYS D 119 27.714 48.486 -3.127 1.00 10.14 C +ATOM 5852 CE LYS D 119 27.852 48.083 -1.672 1.00 15.19 C +ATOM 5853 NZ LYS D 119 26.573 47.631 -1.061 1.00 17.54 N +ATOM 5854 N SER D 120 30.436 48.269 -7.800 1.00 15.09 N +ATOM 5855 CA SER D 120 30.473 48.118 -9.252 1.00 10.52 C +ATOM 5856 C SER D 120 29.088 47.744 -9.751 1.00 8.50 C +ATOM 5857 O SER D 120 28.395 46.957 -9.129 1.00 9.46 O +ATOM 5858 CB SER D 120 31.495 47.045 -9.649 1.00 14.98 C +ATOM 5859 OG SER D 120 31.938 47.186 -10.995 1.00 8.50 O +ATOM 5860 N LEU D 121 28.684 48.314 -10.873 1.00 8.50 N +ATOM 5861 CA LEU D 121 27.381 48.037 -11.445 1.00 8.50 C +ATOM 5862 C LEU D 121 27.278 48.527 -12.889 1.00 16.89 C +ATOM 5863 O LEU D 121 27.644 49.667 -13.199 1.00 13.95 O +ATOM 5864 CB LEU D 121 26.289 48.659 -10.590 1.00 8.50 C +ATOM 5865 CG LEU D 121 24.880 48.787 -11.146 1.00 8.50 C +ATOM 5866 CD1 LEU D 121 24.350 47.462 -11.480 1.00 10.86 C +ATOM 5867 CD2 LEU D 121 23.992 49.428 -10.124 1.00 11.24 C +ATOM 5868 N LYS D 122 26.850 47.613 -13.770 1.00 21.65 N +ATOM 5869 CA LYS D 122 26.650 47.852 -15.211 1.00 11.91 C +ATOM 5870 C LYS D 122 27.805 48.472 -15.980 1.00 15.29 C +ATOM 5871 O LYS D 122 27.602 49.412 -16.752 1.00 18.72 O +ATOM 5872 CB LYS D 122 25.388 48.679 -15.450 1.00 8.50 C +ATOM 5873 CG LYS D 122 24.125 47.871 -15.442 1.00 19.73 C +ATOM 5874 CD LYS D 122 24.029 46.996 -16.678 1.00 19.80 C +ATOM 5875 CE LYS D 122 22.746 46.190 -16.677 1.00 21.93 C +ATOM 5876 NZ LYS D 122 22.595 45.387 -17.911 1.00 41.83 N +ATOM 5877 N LYS D 123 29.006 47.929 -15.817 1.00 12.79 N +ATOM 5878 CA LYS D 123 30.161 48.477 -16.523 1.00 13.62 C +ATOM 5879 C LYS D 123 29.946 48.345 -18.024 1.00 19.62 C +ATOM 5880 O LYS D 123 29.359 47.362 -18.492 1.00 30.68 O +ATOM 5881 CB LYS D 123 31.447 47.752 -16.141 1.00 8.50 C +ATOM 5882 CG LYS D 123 32.631 48.302 -16.907 1.00 8.50 C +ATOM 5883 CD LYS D 123 33.742 47.300 -17.069 1.00 16.42 C +ATOM 5884 CE LYS D 123 34.561 47.123 -15.815 1.00 23.64 C +ATOM 5885 NZ LYS D 123 35.835 46.396 -16.127 1.00 31.68 N +ATOM 5886 N GLY D 124 30.404 49.329 -18.780 1.00 18.22 N +ATOM 5887 CA GLY D 124 30.241 49.265 -20.215 1.00 20.43 C +ATOM 5888 C GLY D 124 28.848 49.594 -20.720 1.00 19.54 C +ATOM 5889 O GLY D 124 28.680 49.842 -21.914 1.00 30.25 O +ATOM 5890 N TYR D 125 27.851 49.611 -19.844 1.00 10.60 N +ATOM 5891 CA TYR D 125 26.494 49.924 -20.267 1.00 14.62 C +ATOM 5892 C TYR D 125 26.441 51.375 -20.744 1.00 17.84 C +ATOM 5893 O TYR D 125 27.422 52.104 -20.629 1.00 20.19 O +ATOM 5894 CB TYR D 125 25.518 49.700 -19.104 1.00 10.00 C +ATOM 5895 CG TYR D 125 24.041 49.833 -19.460 1.00 17.05 C +ATOM 5896 CD1 TYR D 125 23.353 48.786 -20.038 1.00 26.73 C +ATOM 5897 CD2 TYR D 125 23.332 51.002 -19.202 1.00 18.98 C +ATOM 5898 CE1 TYR D 125 21.999 48.901 -20.346 1.00 29.79 C +ATOM 5899 CE2 TYR D 125 21.981 51.121 -19.510 1.00 13.33 C +ATOM 5900 CZ TYR D 125 21.324 50.073 -20.079 1.00 15.85 C +ATOM 5901 OH TYR D 125 19.990 50.171 -20.394 1.00 14.41 O +ATOM 5902 N THR D 126 25.308 51.782 -21.309 1.00 21.18 N +ATOM 5903 CA THR D 126 25.120 53.161 -21.765 1.00 23.32 C +ATOM 5904 C THR D 126 23.632 53.517 -21.630 1.00 23.19 C +ATOM 5905 O THR D 126 22.759 52.820 -22.165 1.00 25.30 O +ATOM 5906 CB THR D 126 25.690 53.374 -23.194 1.00 22.63 C +ATOM 5907 OG1 THR D 126 25.091 54.523 -23.800 1.00 17.57 O +ATOM 5908 CG2 THR D 126 25.470 52.133 -24.062 1.00 37.85 C +ATOM 5909 N VAL D 127 23.354 54.534 -20.815 1.00 21.62 N +ATOM 5910 CA VAL D 127 21.987 54.955 -20.538 1.00 18.60 C +ATOM 5911 C VAL D 127 21.323 55.661 -21.722 1.00 16.26 C +ATOM 5912 O VAL D 127 21.944 56.463 -22.408 1.00 10.25 O +ATOM 5913 CB VAL D 127 21.934 55.819 -19.245 1.00 13.70 C +ATOM 5914 CG1 VAL D 127 20.534 56.334 -18.997 1.00 16.89 C +ATOM 5915 CG2 VAL D 127 22.390 55.008 -18.056 1.00 8.50 C +ATOM 5916 N GLY D 128 20.058 55.333 -21.954 1.00 18.18 N +ATOM 5917 CA GLY D 128 19.303 55.933 -23.040 1.00 26.63 C +ATOM 5918 C GLY D 128 19.083 57.433 -22.900 1.00 28.98 C +ATOM 5919 O GLY D 128 18.836 57.923 -21.799 1.00 33.28 O +ATOM 5920 N ALA D 129 19.115 58.138 -24.031 1.00 29.63 N +ATOM 5921 CA ALA D 129 18.957 59.588 -24.074 1.00 33.09 C +ATOM 5922 C ALA D 129 17.527 60.135 -24.013 1.00 42.85 C +ATOM 5923 O ALA D 129 17.291 61.201 -23.424 1.00 49.32 O +ATOM 5924 CB ALA D 129 19.667 60.144 -25.279 1.00 29.42 C +ATOM 5925 N GLU D 130 16.578 59.465 -24.659 1.00 44.15 N +ATOM 5926 CA GLU D 130 15.196 59.948 -24.612 1.00 48.86 C +ATOM 5927 C GLU D 130 14.502 59.221 -23.481 1.00 46.07 C +ATOM 5928 O GLU D 130 14.287 58.004 -23.561 1.00 49.51 O +ATOM 5929 CB GLU D 130 14.481 59.727 -25.944 1.00 65.82 C +ATOM 5930 CG GLU D 130 14.538 58.301 -26.480 1.00 94.48 C +ATOM 5931 CD GLU D 130 13.811 58.155 -27.811 1.00105.13 C +ATOM 5932 OE1 GLU D 130 14.449 58.378 -28.867 1.00111.21 O +ATOM 5933 OE2 GLU D 130 12.601 57.826 -27.800 1.00110.24 O +ATOM 5934 N ALA D 131 14.160 59.954 -22.423 1.00 38.28 N +ATOM 5935 CA ALA D 131 13.544 59.326 -21.268 1.00 28.40 C +ATOM 5936 C ALA D 131 12.454 60.110 -20.593 1.00 20.48 C +ATOM 5937 O ALA D 131 12.341 61.317 -20.755 1.00 25.51 O +ATOM 5938 CB ALA D 131 14.610 58.994 -20.267 1.00 25.91 C +ATOM 5939 N SER D 132 11.644 59.391 -19.834 1.00 15.84 N +ATOM 5940 CA SER D 132 10.561 59.970 -19.068 1.00 19.37 C +ATOM 5941 C SER D 132 11.085 59.929 -17.637 1.00 21.98 C +ATOM 5942 O SER D 132 11.389 58.854 -17.116 1.00 24.25 O +ATOM 5943 CB SER D 132 9.299 59.114 -19.206 1.00 19.27 C +ATOM 5944 OG SER D 132 8.216 59.648 -18.461 1.00 33.69 O +ATOM 5945 N ILE D 133 11.273 61.106 -17.050 1.00 16.49 N +ATOM 5946 CA ILE D 133 11.783 61.245 -15.701 1.00 12.23 C +ATOM 5947 C ILE D 133 10.617 61.635 -14.794 1.00 14.94 C +ATOM 5948 O ILE D 133 10.023 62.698 -14.973 1.00 23.60 O +ATOM 5949 CB ILE D 133 12.879 62.324 -15.671 1.00 9.62 C +ATOM 5950 CG1 ILE D 133 13.957 61.985 -16.698 1.00 8.50 C +ATOM 5951 CG2 ILE D 133 13.495 62.435 -14.275 1.00 22.10 C +ATOM 5952 CD1 ILE D 133 15.036 63.007 -16.789 1.00 12.97 C +ATOM 5953 N ILE D 134 10.282 60.791 -13.821 1.00 10.56 N +ATOM 5954 CA ILE D 134 9.173 61.099 -12.944 1.00 11.04 C +ATOM 5955 C ILE D 134 9.512 61.116 -11.469 1.00 10.79 C +ATOM 5956 O ILE D 134 10.315 60.334 -10.981 1.00 15.16 O +ATOM 5957 CB ILE D 134 7.985 60.170 -13.250 1.00 18.58 C +ATOM 5958 CG1 ILE D 134 7.319 60.648 -14.544 1.00 21.13 C +ATOM 5959 CG2 ILE D 134 6.996 60.111 -12.068 1.00 18.65 C +ATOM 5960 CD1 ILE D 134 6.123 59.829 -14.977 1.00 41.68 C +ATOM 5961 N LEU D 135 8.887 62.045 -10.771 1.00 9.33 N +ATOM 5962 CA LEU D 135 9.091 62.219 -9.351 1.00 9.20 C +ATOM 5963 C LEU D 135 7.829 61.797 -8.625 1.00 11.57 C +ATOM 5964 O LEU D 135 6.711 62.143 -9.043 1.00 12.52 O +ATOM 5965 CB LEU D 135 9.377 63.704 -9.067 1.00 14.41 C +ATOM 5966 CG LEU D 135 10.816 64.214 -8.879 1.00 8.50 C +ATOM 5967 CD1 LEU D 135 11.798 63.515 -9.768 1.00 10.40 C +ATOM 5968 CD2 LEU D 135 10.850 65.691 -9.131 1.00 8.50 C +ATOM 5969 N GLY D 136 8.004 61.020 -7.559 1.00 11.94 N +ATOM 5970 CA GLY D 136 6.874 60.594 -6.760 1.00 26.09 C +ATOM 5971 C GLY D 136 6.219 59.265 -7.098 1.00 29.51 C +ATOM 5972 O GLY D 136 5.343 58.811 -6.355 1.00 28.31 O +ATOM 5973 N GLN D 137 6.827 58.553 -8.055 1.00 23.26 N +ATOM 5974 CA GLN D 137 6.288 57.289 -8.532 1.00 15.07 C +ATOM 5975 C GLN D 137 7.217 56.556 -9.491 1.00 18.44 C +ATOM 5976 O GLN D 137 7.952 57.174 -10.280 1.00 8.50 O +ATOM 5977 CB GLN D 137 4.947 57.541 -9.234 1.00 9.13 C +ATOM 5978 CG GLN D 137 4.212 56.302 -9.646 1.00 8.50 C +ATOM 5979 CD GLN D 137 2.856 56.597 -10.242 1.00 23.96 C +ATOM 5980 OE1 GLN D 137 2.728 56.780 -11.455 1.00 35.79 O +ATOM 5981 NE2 GLN D 137 1.829 56.632 -9.396 1.00 27.38 N +ATOM 5982 N GLU D 138 7.164 55.221 -9.404 1.00 34.66 N +ATOM 5983 CA GLU D 138 7.936 54.313 -10.251 1.00 37.62 C +ATOM 5984 C GLU D 138 7.381 54.431 -11.675 1.00 38.61 C +ATOM 5985 O GLU D 138 6.239 54.862 -11.884 1.00 37.63 O +ATOM 5986 CB GLU D 138 7.808 52.877 -9.749 1.00 35.62 C +ATOM 5987 CG GLU D 138 8.522 51.858 -10.619 1.00 53.06 C +ATOM 5988 CD GLU D 138 8.618 50.482 -9.977 1.00 68.51 C +ATOM 5989 OE1 GLU D 138 7.797 50.168 -9.078 1.00 77.01 O +ATOM 5990 OE2 GLU D 138 9.525 49.712 -10.377 1.00 66.85 O +ATOM 5991 N GLN D 139 8.157 54.013 -12.660 1.00 34.87 N +ATOM 5992 CA GLN D 139 7.674 54.168 -14.009 1.00 35.23 C +ATOM 5993 C GLN D 139 7.845 52.938 -14.865 1.00 38.38 C +ATOM 5994 O GLN D 139 8.962 52.596 -15.245 1.00 35.31 O +ATOM 5995 CB GLN D 139 8.397 55.321 -14.637 1.00 32.82 C +ATOM 5996 CG GLN D 139 7.599 55.992 -15.674 1.00 35.43 C +ATOM 5997 CD GLN D 139 8.489 56.779 -16.575 1.00 31.62 C +ATOM 5998 OE1 GLN D 139 8.354 56.718 -17.801 1.00 37.13 O +ATOM 5999 NE2 GLN D 139 9.444 57.491 -15.984 1.00 16.84 N +ATOM 6000 N ASP D 140 6.718 52.316 -15.207 1.00 47.08 N +ATOM 6001 CA ASP D 140 6.705 51.094 -16.010 1.00 64.23 C +ATOM 6002 C ASP D 140 5.772 51.314 -17.199 1.00 71.92 C +ATOM 6003 O ASP D 140 4.633 50.829 -17.255 1.00 59.51 O +ATOM 6004 CB ASP D 140 6.282 49.909 -15.135 1.00 76.52 C +ATOM 6005 CG ASP D 140 6.922 49.959 -13.739 1.00 89.83 C +ATOM 6006 OD1 ASP D 140 8.120 49.605 -13.602 1.00 88.76 O +ATOM 6007 OD2 ASP D 140 6.233 50.400 -12.786 1.00 99.23 O +ATOM 6008 N SER D 141 6.323 52.099 -18.126 1.00 90.29 N +ATOM 6009 CA SER D 141 5.729 52.573 -19.382 1.00102.98 C +ATOM 6010 C SER D 141 4.497 51.923 -20.035 1.00105.57 C +ATOM 6011 O SER D 141 3.355 52.390 -19.839 1.00108.63 O +ATOM 6012 CB SER D 141 6.847 52.783 -20.435 1.00106.53 C +ATOM 6013 OG SER D 141 7.648 53.929 -20.138 1.00109.62 O +ATOM 6014 N PHE D 142 4.724 50.879 -20.826 1.00103.23 N +ATOM 6015 CA PHE D 142 3.632 50.232 -21.543 1.00104.98 C +ATOM 6016 C PHE D 142 2.514 49.537 -20.746 1.00105.81 C +ATOM 6017 O PHE D 142 1.836 48.656 -21.285 1.00103.28 O +ATOM 6018 CB PHE D 142 4.190 49.327 -22.663 1.00109.24 C +ATOM 6019 CG PHE D 142 5.378 48.465 -22.257 1.00113.70 C +ATOM 6020 CD1 PHE D 142 5.184 47.202 -21.677 1.00109.21 C +ATOM 6021 CD2 PHE D 142 6.686 48.882 -22.535 1.00112.96 C +ATOM 6022 CE1 PHE D 142 6.272 46.364 -21.385 1.00105.46 C +ATOM 6023 CE2 PHE D 142 7.781 48.050 -22.248 1.00116.69 C +ATOM 6024 CZ PHE D 142 7.572 46.784 -21.671 1.00108.62 C +ATOM 6025 N GLY D 143 2.294 49.969 -19.498 1.00106.68 N +ATOM 6026 CA GLY D 143 1.253 49.396 -18.652 1.00103.36 C +ATOM 6027 C GLY D 143 1.433 47.896 -18.549 1.00101.71 C +ATOM 6028 O GLY D 143 2.141 47.301 -19.342 1.00105.66 O +ATOM 6029 N GLY D 144 0.848 47.254 -17.562 1.00 98.79 N +ATOM 6030 CA GLY D 144 1.038 45.821 -17.496 1.00 95.19 C +ATOM 6031 C GLY D 144 1.207 45.333 -16.086 1.00 91.19 C +ATOM 6032 O GLY D 144 1.265 44.131 -15.869 1.00 99.72 O +ATOM 6033 N ASN D 145 1.356 46.249 -15.132 1.00 80.68 N +ATOM 6034 CA ASN D 145 1.478 45.850 -13.736 1.00 63.86 C +ATOM 6035 C ASN D 145 0.051 45.535 -13.313 1.00 43.96 C +ATOM 6036 O ASN D 145 -0.887 46.133 -13.832 1.00 34.06 O +ATOM 6037 CB ASN D 145 2.091 46.957 -12.858 1.00 79.10 C +ATOM 6038 CG ASN D 145 3.521 47.371 -13.300 1.00 86.31 C +ATOM 6039 OD1 ASN D 145 3.875 48.554 -13.208 1.00 92.09 O +ATOM 6040 ND2 ASN D 145 4.343 46.404 -13.752 1.00 74.29 N +ATOM 6041 N PHE D 146 -0.124 44.568 -12.425 1.00 34.36 N +ATOM 6042 CA PHE D 146 -1.463 44.187 -12.007 1.00 39.46 C +ATOM 6043 C PHE D 146 -2.134 45.301 -11.236 1.00 40.01 C +ATOM 6044 O PHE D 146 -3.311 45.618 -11.450 1.00 33.21 O +ATOM 6045 CB PHE D 146 -1.433 42.880 -11.178 1.00 48.21 C +ATOM 6046 CG PHE D 146 -2.776 42.508 -10.552 1.00 47.24 C +ATOM 6047 CD1 PHE D 146 -3.976 43.003 -11.059 1.00 42.40 C +ATOM 6048 CD2 PHE D 146 -2.830 41.741 -9.400 1.00 34.66 C +ATOM 6049 CE1 PHE D 146 -5.189 42.750 -10.435 1.00 31.65 C +ATOM 6050 CE2 PHE D 146 -4.056 41.487 -8.765 1.00 21.97 C +ATOM 6051 CZ PHE D 146 -5.225 41.993 -9.281 1.00 12.91 C +ATOM 6052 N GLU D 147 -1.390 45.871 -10.305 1.00 44.47 N +ATOM 6053 CA GLU D 147 -1.927 46.949 -9.487 1.00 51.39 C +ATOM 6054 C GLU D 147 -1.076 48.207 -9.619 1.00 57.57 C +ATOM 6055 O GLU D 147 0.009 48.164 -10.181 1.00 49.47 O +ATOM 6056 CB GLU D 147 -2.000 46.509 -8.026 1.00 48.66 C +ATOM 6057 CG GLU D 147 -3.290 45.796 -7.662 1.00 48.27 C +ATOM 6058 CD GLU D 147 -3.163 45.047 -6.338 1.00 47.00 C +ATOM 6059 OE1 GLU D 147 -2.244 44.199 -6.208 1.00 40.06 O +ATOM 6060 OE2 GLU D 147 -3.974 45.310 -5.419 1.00 43.14 O +ATOM 6061 N GLY D 148 -1.580 49.326 -9.113 1.00 57.96 N +ATOM 6062 CA GLY D 148 -0.843 50.578 -9.179 1.00 60.82 C +ATOM 6063 C GLY D 148 0.594 50.607 -8.691 1.00 62.62 C +ATOM 6064 O GLY D 148 1.097 49.653 -8.094 1.00 66.35 O +ATOM 6065 N SER D 149 1.211 51.770 -8.865 1.00 62.33 N +ATOM 6066 CA SER D 149 2.593 51.978 -8.486 1.00 62.69 C +ATOM 6067 C SER D 149 2.721 52.490 -7.041 1.00 57.94 C +ATOM 6068 O SER D 149 3.677 52.141 -6.337 1.00 66.26 O +ATOM 6069 CB SER D 149 3.239 52.931 -9.501 1.00 72.13 C +ATOM 6070 OG SER D 149 2.564 52.857 -10.759 1.00 69.38 O +ATOM 6071 N GLN D 150 1.737 53.268 -6.591 1.00 48.20 N +ATOM 6072 CA GLN D 150 1.736 53.830 -5.234 1.00 46.12 C +ATOM 6073 C GLN D 150 2.893 54.832 -5.037 1.00 44.76 C +ATOM 6074 O GLN D 150 4.069 54.458 -4.924 1.00 49.00 O +ATOM 6075 CB GLN D 150 1.775 52.708 -4.182 1.00 42.55 C +ATOM 6076 CG GLN D 150 1.534 53.145 -2.723 1.00 58.57 C +ATOM 6077 CD GLN D 150 0.092 53.606 -2.433 1.00 66.31 C +ATOM 6078 OE1 GLN D 150 -0.807 52.794 -2.193 1.00 54.94 O +ATOM 6079 NE2 GLN D 150 -0.115 54.920 -2.415 1.00 79.63 N +ATOM 6080 N SER D 151 2.516 56.107 -4.960 1.00 31.73 N +ATOM 6081 CA SER D 151 3.431 57.231 -4.847 1.00 21.60 C +ATOM 6082 C SER D 151 4.067 57.569 -3.507 1.00 20.55 C +ATOM 6083 O SER D 151 3.550 57.180 -2.472 1.00 27.36 O +ATOM 6084 CB SER D 151 2.669 58.457 -5.317 1.00 14.88 C +ATOM 6085 OG SER D 151 2.172 58.262 -6.636 1.00 24.40 O +ATOM 6086 N LEU D 152 5.200 58.287 -3.569 1.00 20.99 N +ATOM 6087 CA LEU D 152 5.961 58.836 -2.435 1.00 15.17 C +ATOM 6088 C LEU D 152 4.992 59.781 -1.722 1.00 13.21 C +ATOM 6089 O LEU D 152 4.186 60.463 -2.368 1.00 10.99 O +ATOM 6090 CB LEU D 152 7.140 59.683 -2.943 1.00 8.50 C +ATOM 6091 CG LEU D 152 7.799 60.655 -1.958 1.00 8.50 C +ATOM 6092 CD1 LEU D 152 8.761 59.919 -1.039 1.00 9.45 C +ATOM 6093 CD2 LEU D 152 8.538 61.705 -2.716 1.00 8.50 C +ATOM 6094 N VAL D 153 5.036 59.787 -0.395 1.00 9.65 N +ATOM 6095 CA VAL D 153 4.174 60.658 0.383 1.00 9.01 C +ATOM 6096 C VAL D 153 5.106 61.479 1.249 1.00 13.45 C +ATOM 6097 O VAL D 153 5.723 60.948 2.172 1.00 12.30 O +ATOM 6098 CB VAL D 153 3.202 59.872 1.272 1.00 8.50 C +ATOM 6099 CG1 VAL D 153 2.185 60.789 1.855 1.00 8.50 C +ATOM 6100 CG2 VAL D 153 2.513 58.804 0.478 1.00 16.18 C +ATOM 6101 N GLY D 154 5.236 62.759 0.903 1.00 16.39 N +ATOM 6102 CA GLY D 154 6.103 63.674 1.618 1.00 11.84 C +ATOM 6103 C GLY D 154 6.578 64.759 0.678 1.00 10.82 C +ATOM 6104 O GLY D 154 5.909 65.076 -0.308 1.00 8.50 O +ATOM 6105 N ASP D 155 7.742 65.319 0.973 1.00 10.30 N +ATOM 6106 CA ASP D 155 8.298 66.389 0.157 1.00 11.90 C +ATOM 6107 C ASP D 155 9.525 65.923 -0.584 1.00 8.82 C +ATOM 6108 O ASP D 155 10.269 65.072 -0.091 1.00 11.06 O +ATOM 6109 CB ASP D 155 8.732 67.569 1.036 1.00 19.39 C +ATOM 6110 CG ASP D 155 7.571 68.317 1.648 1.00 10.32 C +ATOM 6111 OD1 ASP D 155 6.754 67.684 2.361 1.00 8.50 O +ATOM 6112 OD2 ASP D 155 7.521 69.551 1.440 1.00 8.50 O +ATOM 6113 N ILE D 156 9.756 66.508 -1.746 1.00 8.50 N +ATOM 6114 CA ILE D 156 10.930 66.183 -2.524 1.00 8.50 C +ATOM 6115 C ILE D 156 11.315 67.460 -3.233 1.00 11.13 C +ATOM 6116 O ILE D 156 10.448 68.199 -3.681 1.00 17.08 O +ATOM 6117 CB ILE D 156 10.684 65.054 -3.528 1.00 8.50 C +ATOM 6118 CG1 ILE D 156 11.977 64.746 -4.261 1.00 8.50 C +ATOM 6119 CG2 ILE D 156 9.618 65.422 -4.508 1.00 8.50 C +ATOM 6120 CD1 ILE D 156 11.849 63.578 -5.172 1.00 8.74 C +ATOM 6121 N GLY D 157 12.603 67.750 -3.289 1.00 8.50 N +ATOM 6122 CA GLY D 157 13.036 68.967 -3.915 1.00 8.50 C +ATOM 6123 C GLY D 157 14.517 68.954 -4.187 1.00 8.50 C +ATOM 6124 O GLY D 157 15.181 67.963 -3.977 1.00 8.50 O +ATOM 6125 N ASN D 158 15.026 70.079 -4.653 1.00 9.19 N +ATOM 6126 CA ASN D 158 16.417 70.236 -4.991 1.00 8.50 C +ATOM 6127 C ASN D 158 17.001 69.148 -5.852 1.00 8.50 C +ATOM 6128 O ASN D 158 18.122 68.729 -5.635 1.00 8.50 O +ATOM 6129 CB ASN D 158 17.263 70.433 -3.748 1.00 11.51 C +ATOM 6130 CG ASN D 158 17.306 71.864 -3.301 1.00 9.62 C +ATOM 6131 OD1 ASN D 158 16.989 72.167 -2.158 1.00 19.83 O +ATOM 6132 ND2 ASN D 158 17.706 72.759 -4.194 1.00 16.72 N +ATOM 6133 N VAL D 159 16.256 68.707 -6.853 1.00 8.50 N +ATOM 6134 CA VAL D 159 16.768 67.673 -7.752 1.00 11.05 C +ATOM 6135 C VAL D 159 17.597 68.323 -8.866 1.00 9.60 C +ATOM 6136 O VAL D 159 17.193 69.325 -9.458 1.00 9.41 O +ATOM 6137 CB VAL D 159 15.641 66.719 -8.316 1.00 8.50 C +ATOM 6138 CG1 VAL D 159 14.271 67.202 -7.959 1.00 8.50 C +ATOM 6139 CG2 VAL D 159 15.759 66.550 -9.798 1.00 8.50 C +ATOM 6140 N ASN D 160 18.799 67.804 -9.076 1.00 8.51 N +ATOM 6141 CA ASN D 160 19.703 68.304 -10.097 1.00 8.50 C +ATOM 6142 C ASN D 160 20.383 67.089 -10.671 1.00 8.69 C +ATOM 6143 O ASN D 160 20.481 66.077 -9.996 1.00 10.71 O +ATOM 6144 CB ASN D 160 20.746 69.224 -9.494 1.00 8.50 C +ATOM 6145 CG ASN D 160 20.150 70.487 -8.910 1.00 15.40 C +ATOM 6146 OD1 ASN D 160 19.900 70.563 -7.718 1.00 31.21 O +ATOM 6147 ND2 ASN D 160 19.926 71.490 -9.746 1.00 25.45 N +ATOM 6148 N MET D 161 20.875 67.191 -11.902 1.00 10.76 N +ATOM 6149 CA MET D 161 21.529 66.063 -12.568 1.00 10.79 C +ATOM 6150 C MET D 161 22.608 66.523 -13.515 1.00 8.50 C +ATOM 6151 O MET D 161 22.401 67.458 -14.262 1.00 11.62 O +ATOM 6152 CB MET D 161 20.486 65.254 -13.338 1.00 14.71 C +ATOM 6153 CG MET D 161 21.021 64.003 -14.006 1.00 13.03 C +ATOM 6154 SD MET D 161 19.668 63.007 -14.611 1.00 8.50 S +ATOM 6155 CE MET D 161 20.550 61.548 -15.080 1.00 8.50 C +ATOM 6156 N TRP D 162 23.760 65.880 -13.451 1.00 8.50 N +ATOM 6157 CA TRP D 162 24.897 66.202 -14.305 1.00 9.39 C +ATOM 6158 C TRP D 162 25.157 64.995 -15.198 1.00 13.58 C +ATOM 6159 O TRP D 162 24.768 63.880 -14.851 1.00 21.56 O +ATOM 6160 CB TRP D 162 26.149 66.460 -13.473 1.00 8.50 C +ATOM 6161 CG TRP D 162 26.092 67.654 -12.557 1.00 9.89 C +ATOM 6162 CD1 TRP D 162 26.746 68.844 -12.725 1.00 11.45 C +ATOM 6163 CD2 TRP D 162 25.410 67.754 -11.297 1.00 13.90 C +ATOM 6164 NE1 TRP D 162 26.518 69.664 -11.655 1.00 9.63 N +ATOM 6165 CE2 TRP D 162 25.704 69.023 -10.760 1.00 11.92 C +ATOM 6166 CE3 TRP D 162 24.583 66.893 -10.569 1.00 18.16 C +ATOM 6167 CZ2 TRP D 162 25.201 69.450 -9.528 1.00 8.50 C +ATOM 6168 CZ3 TRP D 162 24.083 67.327 -9.343 1.00 10.21 C +ATOM 6169 CH2 TRP D 162 24.397 68.592 -8.841 1.00 8.50 C +ATOM 6170 N ASP D 163 25.795 65.202 -16.344 1.00 11.46 N +ATOM 6171 CA ASP D 163 26.086 64.095 -17.250 1.00 11.76 C +ATOM 6172 C ASP D 163 27.477 63.525 -17.029 1.00 14.12 C +ATOM 6173 O ASP D 163 27.989 62.767 -17.867 1.00 14.91 O +ATOM 6174 CB ASP D 163 25.881 64.491 -18.728 1.00 20.87 C +ATOM 6175 CG ASP D 163 26.877 65.565 -19.238 1.00 27.30 C +ATOM 6176 OD1 ASP D 163 27.997 65.707 -18.708 1.00 32.78 O +ATOM 6177 OD2 ASP D 163 26.543 66.265 -20.218 1.00 25.93 O +ATOM 6178 N PHE D 164 28.111 63.959 -15.936 1.00 13.21 N +ATOM 6179 CA PHE D 164 29.448 63.484 -15.554 1.00 11.21 C +ATOM 6180 C PHE D 164 29.466 63.185 -14.065 1.00 9.32 C +ATOM 6181 O PHE D 164 28.492 63.465 -13.364 1.00 14.81 O +ATOM 6182 CB PHE D 164 30.542 64.490 -15.921 1.00 9.37 C +ATOM 6183 CG PHE D 164 30.403 65.821 -15.252 1.00 12.65 C +ATOM 6184 CD1 PHE D 164 29.573 66.806 -15.793 1.00 14.41 C +ATOM 6185 CD2 PHE D 164 31.114 66.099 -14.084 1.00 9.71 C +ATOM 6186 CE1 PHE D 164 29.454 68.053 -15.180 1.00 21.97 C +ATOM 6187 CE2 PHE D 164 31.003 67.339 -13.457 1.00 12.61 C +ATOM 6188 CZ PHE D 164 30.173 68.320 -14.004 1.00 21.44 C +ATOM 6189 N VAL D 165 30.561 62.620 -13.576 1.00 9.83 N +ATOM 6190 CA VAL D 165 30.653 62.259 -12.166 1.00 9.90 C +ATOM 6191 C VAL D 165 31.268 63.355 -11.290 1.00 10.04 C +ATOM 6192 O VAL D 165 32.439 63.719 -11.456 1.00 10.36 O +ATOM 6193 CB VAL D 165 31.446 60.930 -11.971 1.00 8.50 C +ATOM 6194 CG1 VAL D 165 31.387 60.484 -10.533 1.00 20.12 C +ATOM 6195 CG2 VAL D 165 30.879 59.845 -12.819 1.00 9.77 C +ATOM 6196 N LEU D 166 30.470 63.866 -10.354 1.00 9.96 N +ATOM 6197 CA LEU D 166 30.920 64.893 -9.425 1.00 8.50 C +ATOM 6198 C LEU D 166 32.014 64.362 -8.501 1.00 8.50 C +ATOM 6199 O LEU D 166 31.987 63.202 -8.064 1.00 10.73 O +ATOM 6200 CB LEU D 166 29.746 65.370 -8.580 1.00 8.50 C +ATOM 6201 CG LEU D 166 29.106 66.698 -8.951 1.00 8.50 C +ATOM 6202 CD1 LEU D 166 28.788 66.711 -10.419 1.00 13.07 C +ATOM 6203 CD2 LEU D 166 27.861 66.912 -8.119 1.00 12.52 C +ATOM 6204 N SER D 167 32.975 65.216 -8.190 1.00 8.50 N +ATOM 6205 CA SER D 167 34.049 64.813 -7.304 1.00 11.80 C +ATOM 6206 C SER D 167 33.599 64.990 -5.862 1.00 11.87 C +ATOM 6207 O SER D 167 32.583 65.621 -5.584 1.00 11.40 O +ATOM 6208 CB SER D 167 35.317 65.626 -7.572 1.00 10.32 C +ATOM 6209 OG SER D 167 35.176 66.955 -7.143 1.00 19.08 O +ATOM 6210 N PRO D 168 34.353 64.435 -4.916 1.00 9.97 N +ATOM 6211 CA PRO D 168 33.997 64.554 -3.514 1.00 8.50 C +ATOM 6212 C PRO D 168 33.868 65.993 -3.072 1.00 11.41 C +ATOM 6213 O PRO D 168 32.987 66.323 -2.292 1.00 16.19 O +ATOM 6214 CB PRO D 168 35.159 63.863 -2.835 1.00 11.97 C +ATOM 6215 CG PRO D 168 35.498 62.781 -3.777 1.00 8.50 C +ATOM 6216 CD PRO D 168 35.499 63.527 -5.077 1.00 16.74 C +ATOM 6217 N ASP D 169 34.743 66.853 -3.581 1.00 14.75 N +ATOM 6218 CA ASP D 169 34.716 68.270 -3.222 1.00 14.31 C +ATOM 6219 C ASP D 169 33.482 68.956 -3.788 1.00 14.72 C +ATOM 6220 O ASP D 169 32.858 69.764 -3.107 1.00 18.02 O +ATOM 6221 CB ASP D 169 35.981 68.981 -3.697 1.00 16.12 C +ATOM 6222 CG ASP D 169 37.259 68.380 -3.100 1.00 36.02 C +ATOM 6223 OD1 ASP D 169 37.440 68.455 -1.855 1.00 40.72 O +ATOM 6224 OD2 ASP D 169 38.091 67.835 -3.877 1.00 41.97 O +ATOM 6225 N GLU D 170 33.108 68.605 -5.015 1.00 8.50 N +ATOM 6226 CA GLU D 170 31.939 69.197 -5.635 1.00 8.50 C +ATOM 6227 C GLU D 170 30.728 68.686 -4.893 1.00 8.50 C +ATOM 6228 O GLU D 170 29.920 69.462 -4.425 1.00 8.50 O +ATOM 6229 CB GLU D 170 31.863 68.834 -7.119 1.00 11.78 C +ATOM 6230 CG GLU D 170 33.126 69.171 -7.909 1.00 18.95 C +ATOM 6231 CD GLU D 170 33.034 68.831 -9.392 1.00 29.91 C +ATOM 6232 OE1 GLU D 170 32.201 69.449 -10.100 1.00 36.96 O +ATOM 6233 OE2 GLU D 170 33.811 67.961 -9.855 1.00 32.51 O +ATOM 6234 N ILE D 171 30.650 67.372 -4.706 1.00 10.85 N +ATOM 6235 CA ILE D 171 29.523 66.767 -3.986 1.00 14.70 C +ATOM 6236 C ILE D 171 29.360 67.401 -2.607 1.00 16.21 C +ATOM 6237 O ILE D 171 28.259 67.506 -2.057 1.00 9.83 O +ATOM 6238 CB ILE D 171 29.700 65.260 -3.824 1.00 8.50 C +ATOM 6239 CG1 ILE D 171 29.529 64.603 -5.193 1.00 14.12 C +ATOM 6240 CG2 ILE D 171 28.672 64.732 -2.841 1.00 8.50 C +ATOM 6241 CD1 ILE D 171 29.629 63.118 -5.202 1.00 28.14 C +ATOM 6242 N ASN D 172 30.477 67.854 -2.063 1.00 21.16 N +ATOM 6243 CA ASN D 172 30.446 68.494 -0.779 1.00 17.37 C +ATOM 6244 C ASN D 172 29.847 69.876 -0.871 1.00 14.18 C +ATOM 6245 O ASN D 172 28.957 70.187 -0.096 1.00 14.32 O +ATOM 6246 CB ASN D 172 31.830 68.585 -0.175 1.00 30.72 C +ATOM 6247 CG ASN D 172 31.789 69.115 1.237 1.00 36.68 C +ATOM 6248 OD1 ASN D 172 32.146 70.259 1.499 1.00 22.51 O +ATOM 6249 ND2 ASN D 172 31.324 68.280 2.159 1.00 48.35 N +ATOM 6250 N THR D 173 30.293 70.701 -1.826 1.00 12.62 N +ATOM 6251 CA THR D 173 29.718 72.047 -1.930 1.00 9.47 C +ATOM 6252 C THR D 173 28.232 71.950 -2.244 1.00 8.50 C +ATOM 6253 O THR D 173 27.462 72.690 -1.676 1.00 10.98 O +ATOM 6254 CB THR D 173 30.436 73.020 -2.938 1.00 8.50 C +ATOM 6255 OG1 THR D 173 29.826 72.933 -4.226 1.00 8.50 O +ATOM 6256 CG2 THR D 173 31.934 72.732 -3.038 1.00 12.89 C +ATOM 6257 N ILE D 174 27.816 71.011 -3.097 1.00 11.51 N +ATOM 6258 CA ILE D 174 26.391 70.864 -3.401 1.00 8.50 C +ATOM 6259 C ILE D 174 25.647 70.674 -2.100 1.00 8.50 C +ATOM 6260 O ILE D 174 24.628 71.311 -1.875 1.00 12.75 O +ATOM 6261 CB ILE D 174 26.064 69.662 -4.298 1.00 8.50 C +ATOM 6262 CG1 ILE D 174 26.293 69.990 -5.767 1.00 9.89 C +ATOM 6263 CG2 ILE D 174 24.617 69.329 -4.197 1.00 8.50 C +ATOM 6264 CD1 ILE D 174 27.734 69.993 -6.183 1.00 27.08 C +ATOM 6265 N TYR D 175 26.167 69.816 -1.234 1.00 8.50 N +ATOM 6266 CA TYR D 175 25.534 69.559 0.058 1.00 8.82 C +ATOM 6267 C TYR D 175 25.485 70.779 0.956 1.00 15.70 C +ATOM 6268 O TYR D 175 24.439 71.099 1.512 1.00 19.55 O +ATOM 6269 CB TYR D 175 26.271 68.463 0.817 1.00 8.84 C +ATOM 6270 CG TYR D 175 25.721 68.227 2.213 1.00 8.50 C +ATOM 6271 CD1 TYR D 175 24.355 68.042 2.417 1.00 12.20 C +ATOM 6272 CD2 TYR D 175 26.562 68.173 3.323 1.00 8.50 C +ATOM 6273 CE1 TYR D 175 23.843 67.803 3.683 1.00 8.50 C +ATOM 6274 CE2 TYR D 175 26.059 67.944 4.583 1.00 8.50 C +ATOM 6275 CZ TYR D 175 24.701 67.756 4.758 1.00 12.30 C +ATOM 6276 OH TYR D 175 24.189 67.502 6.007 1.00 34.92 O +ATOM 6277 N LEU D 176 26.642 71.418 1.126 1.00 20.13 N +ATOM 6278 CA LEU D 176 26.794 72.602 1.971 1.00 19.73 C +ATOM 6279 C LEU D 176 26.131 73.888 1.449 1.00 24.63 C +ATOM 6280 O LEU D 176 26.093 74.897 2.148 1.00 24.58 O +ATOM 6281 CB LEU D 176 28.277 72.853 2.213 1.00 11.53 C +ATOM 6282 CG LEU D 176 28.808 72.505 3.579 1.00 8.50 C +ATOM 6283 CD1 LEU D 176 27.925 71.521 4.275 1.00 8.50 C +ATOM 6284 CD2 LEU D 176 30.202 71.982 3.392 1.00 22.22 C +ATOM 6285 N GLY D 177 25.630 73.849 0.222 1.00 26.02 N +ATOM 6286 CA GLY D 177 24.991 75.008 -0.351 1.00 29.75 C +ATOM 6287 C GLY D 177 25.992 75.937 -1.003 1.00 32.15 C +ATOM 6288 O GLY D 177 26.167 77.068 -0.625 1.00 43.38 O +ATOM 6289 N GLY D 178 26.745 75.428 -1.940 1.00 34.50 N +ATOM 6290 CA GLY D 178 27.676 76.285 -2.620 1.00 33.56 C +ATOM 6291 C GLY D 178 27.069 76.543 -3.990 1.00 34.77 C +ATOM 6292 O GLY D 178 25.914 76.194 -4.241 1.00 31.87 O +ATOM 6293 N PRO D 179 27.796 77.232 -4.875 1.00 33.81 N +ATOM 6294 CA PRO D 179 27.293 77.511 -6.214 1.00 30.70 C +ATOM 6295 C PRO D 179 27.808 76.460 -7.190 1.00 29.35 C +ATOM 6296 O PRO D 179 28.965 76.042 -7.118 1.00 31.25 O +ATOM 6297 CB PRO D 179 27.871 78.884 -6.502 1.00 31.70 C +ATOM 6298 CG PRO D 179 29.155 78.843 -5.842 1.00 15.96 C +ATOM 6299 CD PRO D 179 28.957 78.088 -4.563 1.00 36.17 C +ATOM 6300 N PHE D 180 26.939 76.027 -8.093 1.00 27.23 N +ATOM 6301 CA PHE D 180 27.283 75.019 -9.087 1.00 24.71 C +ATOM 6302 C PHE D 180 26.322 75.137 -10.270 1.00 26.49 C +ATOM 6303 O PHE D 180 25.291 75.807 -10.173 1.00 24.72 O +ATOM 6304 CB PHE D 180 27.168 73.632 -8.458 1.00 19.44 C +ATOM 6305 CG PHE D 180 25.860 73.401 -7.761 1.00 13.90 C +ATOM 6306 CD1 PHE D 180 25.704 73.744 -6.430 1.00 23.58 C +ATOM 6307 CD2 PHE D 180 24.772 72.881 -8.445 1.00 17.74 C +ATOM 6308 CE1 PHE D 180 24.482 73.579 -5.789 1.00 19.18 C +ATOM 6309 CE2 PHE D 180 23.542 72.712 -7.813 1.00 16.05 C +ATOM 6310 CZ PHE D 180 23.402 73.064 -6.484 1.00 18.26 C +ATOM 6311 N SER D 181 26.652 74.464 -11.370 1.00 28.47 N +ATOM 6312 CA SER D 181 25.818 74.476 -12.566 1.00 26.78 C +ATOM 6313 C SER D 181 25.583 73.091 -13.175 1.00 24.28 C +ATOM 6314 O SER D 181 26.474 72.518 -13.806 1.00 33.27 O +ATOM 6315 CB SER D 181 26.427 75.396 -13.613 1.00 26.90 C +ATOM 6316 OG SER D 181 25.596 76.519 -13.826 1.00 58.47 O +ATOM 6317 N PRO D 182 24.394 72.510 -12.939 1.00 17.03 N +ATOM 6318 CA PRO D 182 24.020 71.196 -13.457 1.00 18.07 C +ATOM 6319 C PRO D 182 23.949 71.332 -14.972 1.00 23.40 C +ATOM 6320 O PRO D 182 23.849 72.450 -15.475 1.00 31.49 O +ATOM 6321 CB PRO D 182 22.617 71.014 -12.899 1.00 8.50 C +ATOM 6322 CG PRO D 182 22.620 71.833 -11.693 1.00 13.48 C +ATOM 6323 CD PRO D 182 23.302 73.061 -12.138 1.00 16.22 C +ATOM 6324 N ASN D 183 23.989 70.224 -15.708 1.00 18.50 N +ATOM 6325 CA ASN D 183 23.909 70.310 -17.157 1.00 9.78 C +ATOM 6326 C ASN D 183 22.957 69.314 -17.808 1.00 13.02 C +ATOM 6327 O ASN D 183 23.120 68.963 -18.967 1.00 21.99 O +ATOM 6328 CB ASN D 183 25.294 70.252 -17.789 1.00 8.50 C +ATOM 6329 CG ASN D 183 25.914 68.891 -17.711 1.00 8.50 C +ATOM 6330 OD1 ASN D 183 25.419 68.024 -17.020 1.00 16.87 O +ATOM 6331 ND2 ASN D 183 27.013 68.693 -18.420 1.00 8.50 N +ATOM 6332 N VAL D 184 21.971 68.852 -17.042 1.00 13.70 N +ATOM 6333 CA VAL D 184 20.946 67.927 -17.522 1.00 8.50 C +ATOM 6334 C VAL D 184 19.645 68.381 -16.865 1.00 11.22 C +ATOM 6335 O VAL D 184 18.731 68.825 -17.548 1.00 19.07 O +ATOM 6336 CB VAL D 184 21.230 66.447 -17.143 1.00 8.51 C +ATOM 6337 CG1 VAL D 184 20.108 65.564 -17.641 1.00 9.94 C +ATOM 6338 CG2 VAL D 184 22.537 65.960 -17.742 1.00 8.50 C +ATOM 6339 N LEU D 185 19.575 68.293 -15.538 1.00 9.29 N +ATOM 6340 CA LEU D 185 18.397 68.731 -14.800 1.00 11.02 C +ATOM 6341 C LEU D 185 18.896 69.856 -13.918 1.00 11.97 C +ATOM 6342 O LEU D 185 19.926 69.707 -13.261 1.00 12.96 O +ATOM 6343 CB LEU D 185 17.833 67.587 -13.950 1.00 8.81 C +ATOM 6344 CG LEU D 185 16.460 67.064 -14.359 1.00 9.14 C +ATOM 6345 CD1 LEU D 185 16.457 66.758 -15.815 1.00 8.50 C +ATOM 6346 CD2 LEU D 185 16.120 65.836 -13.578 1.00 19.33 C +ATOM 6347 N ASN D 186 18.204 70.991 -13.939 1.00 13.25 N +ATOM 6348 CA ASN D 186 18.602 72.153 -13.144 1.00 11.52 C +ATOM 6349 C ASN D 186 17.406 72.667 -12.348 1.00 12.19 C +ATOM 6350 O ASN D 186 16.434 73.121 -12.925 1.00 18.68 O +ATOM 6351 CB ASN D 186 19.129 73.252 -14.071 1.00 10.79 C +ATOM 6352 CG ASN D 186 19.718 74.419 -13.328 1.00 8.50 C +ATOM 6353 OD1 ASN D 186 19.358 74.692 -12.195 1.00 12.70 O +ATOM 6354 ND2 ASN D 186 20.638 75.111 -13.963 1.00 15.11 N +ATOM 6355 N TRP D 187 17.485 72.595 -11.023 1.00 12.74 N +ATOM 6356 CA TRP D 187 16.402 73.035 -10.146 1.00 10.76 C +ATOM 6357 C TRP D 187 16.124 74.538 -10.266 1.00 13.14 C +ATOM 6358 O TRP D 187 15.041 75.014 -9.910 1.00 13.82 O +ATOM 6359 CB TRP D 187 16.712 72.656 -8.692 1.00 8.50 C +ATOM 6360 CG TRP D 187 15.535 72.683 -7.760 1.00 8.50 C +ATOM 6361 CD1 TRP D 187 15.345 73.530 -6.711 1.00 8.50 C +ATOM 6362 CD2 TRP D 187 14.403 71.825 -7.787 1.00 8.50 C +ATOM 6363 NE1 TRP D 187 14.162 73.261 -6.083 1.00 8.50 N +ATOM 6364 CE2 TRP D 187 13.559 72.218 -6.724 1.00 8.50 C +ATOM 6365 CE3 TRP D 187 14.009 70.767 -8.604 1.00 8.50 C +ATOM 6366 CZ2 TRP D 187 12.335 71.583 -6.461 1.00 13.87 C +ATOM 6367 CZ3 TRP D 187 12.795 70.134 -8.345 1.00 8.50 C +ATOM 6368 CH2 TRP D 187 11.972 70.544 -7.284 1.00 8.50 C +ATOM 6369 N ARG D 188 17.094 75.283 -10.776 1.00 11.91 N +ATOM 6370 CA ARG D 188 16.948 76.720 -10.951 1.00 17.95 C +ATOM 6371 C ARG D 188 16.248 77.086 -12.270 1.00 23.27 C +ATOM 6372 O ARG D 188 15.767 78.198 -12.456 1.00 27.62 O +ATOM 6373 CB ARG D 188 18.332 77.332 -10.925 1.00 19.48 C +ATOM 6374 CG ARG D 188 19.068 77.037 -9.661 1.00 17.69 C +ATOM 6375 CD ARG D 188 18.655 78.016 -8.597 1.00 32.15 C +ATOM 6376 NE ARG D 188 19.631 79.090 -8.399 1.00 26.98 N +ATOM 6377 CZ ARG D 188 19.316 80.367 -8.215 1.00 8.89 C +ATOM 6378 NH1 ARG D 188 18.050 80.766 -8.221 1.00 8.50 N +ATOM 6379 NH2 ARG D 188 20.275 81.222 -7.928 1.00 9.06 N +ATOM 6380 N ALA D 189 16.224 76.143 -13.195 1.00 25.97 N +ATOM 6381 CA ALA D 189 15.606 76.334 -14.495 1.00 19.00 C +ATOM 6382 C ALA D 189 14.920 75.014 -14.809 1.00 20.54 C +ATOM 6383 O ALA D 189 15.205 74.370 -15.827 1.00 27.13 O +ATOM 6384 CB ALA D 189 16.678 76.637 -15.536 1.00 12.19 C +ATOM 6385 N LEU D 190 14.044 74.593 -13.905 1.00 15.48 N +ATOM 6386 CA LEU D 190 13.339 73.332 -14.064 1.00 19.81 C +ATOM 6387 C LEU D 190 12.166 73.478 -15.033 1.00 25.45 C +ATOM 6388 O LEU D 190 11.478 74.511 -15.054 1.00 26.05 O +ATOM 6389 CB LEU D 190 12.831 72.845 -12.712 1.00 8.50 C +ATOM 6390 CG LEU D 190 12.466 71.374 -12.632 1.00 8.50 C +ATOM 6391 CD1 LEU D 190 13.753 70.568 -12.491 1.00 8.50 C +ATOM 6392 CD2 LEU D 190 11.534 71.130 -11.463 1.00 8.50 C +ATOM 6393 N LYS D 191 11.973 72.466 -15.873 1.00 29.80 N +ATOM 6394 CA LYS D 191 10.873 72.451 -16.836 1.00 27.63 C +ATOM 6395 C LYS D 191 10.111 71.184 -16.469 1.00 24.04 C +ATOM 6396 O LYS D 191 10.557 70.077 -16.749 1.00 25.01 O +ATOM 6397 CB LYS D 191 11.426 72.392 -18.262 1.00 39.56 C +ATOM 6398 CG LYS D 191 10.518 72.995 -19.323 1.00 57.74 C +ATOM 6399 CD LYS D 191 11.301 73.345 -20.588 1.00 73.73 C +ATOM 6400 CE LYS D 191 10.405 74.006 -21.633 1.00 86.41 C +ATOM 6401 NZ LYS D 191 11.179 74.502 -22.810 1.00 94.64 N +ATOM 6402 N TYR D 192 8.983 71.350 -15.795 1.00 23.46 N +ATOM 6403 CA TYR D 192 8.206 70.217 -15.330 1.00 24.87 C +ATOM 6404 C TYR D 192 6.727 70.303 -15.651 1.00 28.23 C +ATOM 6405 O TYR D 192 6.245 71.302 -16.168 1.00 35.82 O +ATOM 6406 CB TYR D 192 8.369 70.091 -13.819 1.00 20.79 C +ATOM 6407 CG TYR D 192 7.829 71.281 -13.070 1.00 15.10 C +ATOM 6408 CD1 TYR D 192 8.545 72.478 -13.017 1.00 16.87 C +ATOM 6409 CD2 TYR D 192 6.594 71.223 -12.429 1.00 8.89 C +ATOM 6410 CE1 TYR D 192 8.039 73.588 -12.345 1.00 19.05 C +ATOM 6411 CE2 TYR D 192 6.079 72.329 -11.748 1.00 8.65 C +ATOM 6412 CZ TYR D 192 6.802 73.508 -11.710 1.00 14.43 C +ATOM 6413 OH TYR D 192 6.285 74.609 -11.052 1.00 24.03 O +ATOM 6414 N GLU D 193 6.005 69.262 -15.266 1.00 30.93 N +ATOM 6415 CA GLU D 193 4.577 69.178 -15.490 1.00 37.22 C +ATOM 6416 C GLU D 193 4.028 68.382 -14.305 1.00 36.77 C +ATOM 6417 O GLU D 193 4.479 67.266 -14.028 1.00 35.32 O +ATOM 6418 CB GLU D 193 4.312 68.461 -16.819 1.00 53.95 C +ATOM 6419 CG GLU D 193 2.908 68.615 -17.393 1.00 66.37 C +ATOM 6420 CD GLU D 193 2.756 67.882 -18.717 1.00 77.28 C +ATOM 6421 OE1 GLU D 193 2.459 66.667 -18.694 1.00 85.18 O +ATOM 6422 OE2 GLU D 193 2.954 68.512 -19.778 1.00 81.45 O +ATOM 6423 N VAL D 194 3.106 68.993 -13.571 1.00 33.90 N +ATOM 6424 CA VAL D 194 2.505 68.376 -12.403 1.00 26.83 C +ATOM 6425 C VAL D 194 1.253 67.635 -12.799 1.00 31.51 C +ATOM 6426 O VAL D 194 0.569 68.032 -13.743 1.00 40.67 O +ATOM 6427 CB VAL D 194 2.165 69.442 -11.372 1.00 27.16 C +ATOM 6428 CG1 VAL D 194 1.333 68.871 -10.241 1.00 25.53 C +ATOM 6429 CG2 VAL D 194 3.447 70.049 -10.842 1.00 28.49 C +ATOM 6430 N GLN D 195 0.951 66.562 -12.078 1.00 32.07 N +ATOM 6431 CA GLN D 195 -0.231 65.751 -12.356 1.00 34.89 C +ATOM 6432 C GLN D 195 -0.787 65.177 -11.067 1.00 24.69 C +ATOM 6433 O GLN D 195 -0.093 64.481 -10.357 1.00 22.21 O +ATOM 6434 CB GLN D 195 0.122 64.599 -13.306 1.00 40.22 C +ATOM 6435 CG GLN D 195 -1.019 64.166 -14.206 1.00 53.65 C +ATOM 6436 CD GLN D 195 -1.390 65.239 -15.212 1.00 72.61 C +ATOM 6437 OE1 GLN D 195 -2.513 65.756 -15.200 1.00 82.37 O +ATOM 6438 NE2 GLN D 195 -0.445 65.588 -16.088 1.00 77.68 N +ATOM 6439 N GLY D 196 -2.030 65.497 -10.748 1.00 22.59 N +ATOM 6440 CA GLY D 196 -2.619 64.956 -9.542 1.00 20.45 C +ATOM 6441 C GLY D 196 -2.535 65.845 -8.329 1.00 28.67 C +ATOM 6442 O GLY D 196 -2.446 67.078 -8.437 1.00 42.00 O +ATOM 6443 N GLU D 197 -2.558 65.215 -7.164 1.00 23.90 N +ATOM 6444 CA GLU D 197 -2.517 65.919 -5.887 1.00 17.74 C +ATOM 6445 C GLU D 197 -1.108 66.268 -5.426 1.00 19.06 C +ATOM 6446 O GLU D 197 -0.605 65.669 -4.472 1.00 23.22 O +ATOM 6447 CB GLU D 197 -3.188 65.071 -4.823 1.00 13.10 C +ATOM 6448 CG GLU D 197 -3.529 65.784 -3.536 1.00 17.84 C +ATOM 6449 CD GLU D 197 -4.924 66.367 -3.547 1.00 26.63 C +ATOM 6450 OE1 GLU D 197 -5.468 66.632 -4.655 1.00 28.51 O +ATOM 6451 OE2 GLU D 197 -5.470 66.547 -2.437 1.00 20.99 O +ATOM 6452 N VAL D 198 -0.463 67.210 -6.113 1.00 15.52 N +ATOM 6453 CA VAL D 198 0.878 67.655 -5.733 1.00 10.24 C +ATOM 6454 C VAL D 198 0.905 69.173 -5.764 1.00 16.59 C +ATOM 6455 O VAL D 198 0.374 69.798 -6.692 1.00 23.15 O +ATOM 6456 CB VAL D 198 1.996 67.023 -6.585 1.00 8.50 C +ATOM 6457 CG1 VAL D 198 1.413 66.358 -7.794 1.00 18.55 C +ATOM 6458 CG2 VAL D 198 3.041 68.048 -6.974 1.00 8.50 C +ATOM 6459 N PHE D 199 1.450 69.753 -4.694 1.00 15.86 N +ATOM 6460 CA PHE D 199 1.542 71.202 -4.528 1.00 14.00 C +ATOM 6461 C PHE D 199 2.987 71.669 -4.425 1.00 11.30 C +ATOM 6462 O PHE D 199 3.881 70.878 -4.142 1.00 15.84 O +ATOM 6463 CB PHE D 199 0.806 71.629 -3.255 1.00 9.36 C +ATOM 6464 CG PHE D 199 -0.566 71.045 -3.112 1.00 8.50 C +ATOM 6465 CD1 PHE D 199 -0.740 69.820 -2.515 1.00 14.44 C +ATOM 6466 CD2 PHE D 199 -1.681 71.727 -3.557 1.00 20.11 C +ATOM 6467 CE1 PHE D 199 -2.007 69.277 -2.365 1.00 23.97 C +ATOM 6468 CE2 PHE D 199 -2.956 71.190 -3.411 1.00 22.76 C +ATOM 6469 CZ PHE D 199 -3.120 69.970 -2.818 1.00 20.72 C +ATOM 6470 N THR D 200 3.197 72.964 -4.627 1.00 12.13 N +ATOM 6471 CA THR D 200 4.523 73.567 -4.535 1.00 11.10 C +ATOM 6472 C THR D 200 4.504 74.467 -3.295 1.00 14.55 C +ATOM 6473 O THR D 200 3.745 75.442 -3.245 1.00 23.83 O +ATOM 6474 CB THR D 200 4.836 74.426 -5.780 1.00 8.50 C +ATOM 6475 OG1 THR D 200 4.700 73.634 -6.961 1.00 26.21 O +ATOM 6476 CG2 THR D 200 6.225 74.951 -5.729 1.00 8.50 C +ATOM 6477 N LYS D 201 5.290 74.107 -2.279 1.00 13.61 N +ATOM 6478 CA LYS D 201 5.365 74.866 -1.037 1.00 8.50 C +ATOM 6479 C LYS D 201 6.822 75.141 -0.672 1.00 8.50 C +ATOM 6480 O LYS D 201 7.732 74.598 -1.288 1.00 8.50 O +ATOM 6481 CB LYS D 201 4.665 74.100 0.086 1.00 8.50 C +ATOM 6482 CG LYS D 201 3.160 73.968 -0.054 1.00 8.50 C +ATOM 6483 CD LYS D 201 2.478 75.307 -0.282 1.00 11.62 C +ATOM 6484 CE LYS D 201 1.031 75.322 0.182 1.00 11.56 C +ATOM 6485 NZ LYS D 201 0.945 75.248 1.679 1.00 30.43 N +ATOM 6486 N PRO D 202 7.064 76.028 0.302 1.00 8.76 N +ATOM 6487 CA PRO D 202 8.430 76.360 0.728 1.00 11.15 C +ATOM 6488 C PRO D 202 9.107 75.144 1.347 1.00 11.14 C +ATOM 6489 O PRO D 202 8.495 74.465 2.154 1.00 15.59 O +ATOM 6490 CB PRO D 202 8.191 77.439 1.787 1.00 10.89 C +ATOM 6491 CG PRO D 202 6.888 78.050 1.381 1.00 8.50 C +ATOM 6492 CD PRO D 202 6.082 76.865 1.018 1.00 8.50 C +ATOM 6493 N GLN D 203 10.376 74.904 1.029 1.00 8.53 N +ATOM 6494 CA GLN D 203 11.086 73.744 1.570 1.00 8.57 C +ATOM 6495 C GLN D 203 11.293 73.789 3.065 1.00 8.50 C +ATOM 6496 O GLN D 203 11.601 74.843 3.608 1.00 8.50 O +ATOM 6497 CB GLN D 203 12.429 73.582 0.892 1.00 11.13 C +ATOM 6498 CG GLN D 203 13.361 74.746 1.057 1.00 8.50 C +ATOM 6499 CD GLN D 203 14.691 74.496 0.376 1.00 16.00 C +ATOM 6500 OE1 GLN D 203 15.749 74.733 0.949 1.00 24.23 O +ATOM 6501 NE2 GLN D 203 14.644 73.997 -0.858 1.00 28.25 N +ATOM 6502 N LEU D 204 11.169 72.625 3.705 1.00 10.00 N +ATOM 6503 CA LEU D 204 11.323 72.505 5.148 1.00 8.50 C +ATOM 6504 C LEU D 204 12.770 72.334 5.563 1.00 9.73 C +ATOM 6505 O LEU D 204 13.132 72.647 6.695 1.00 17.21 O +ATOM 6506 CB LEU D 204 10.493 71.360 5.699 1.00 8.50 C +ATOM 6507 CG LEU D 204 9.046 71.409 5.275 1.00 8.50 C +ATOM 6508 CD1 LEU D 204 8.923 70.515 4.061 1.00 27.57 C +ATOM 6509 CD2 LEU D 204 8.147 70.933 6.371 1.00 8.50 C +ATOM 6510 N TRP D 205 13.585 71.751 4.691 1.00 11.18 N +ATOM 6511 CA TRP D 205 15.001 71.589 4.998 1.00 16.26 C +ATOM 6512 C TRP D 205 15.633 72.934 4.708 1.00 26.04 C +ATOM 6513 O TRP D 205 15.117 73.691 3.893 1.00 36.68 O +ATOM 6514 CB TRP D 205 15.656 70.513 4.137 1.00 8.50 C +ATOM 6515 CG TRP D 205 15.242 70.512 2.717 1.00 8.50 C +ATOM 6516 CD1 TRP D 205 15.811 71.201 1.713 1.00 8.50 C +ATOM 6517 CD2 TRP D 205 14.166 69.759 2.131 1.00 12.10 C +ATOM 6518 NE1 TRP D 205 15.170 70.937 0.530 1.00 8.50 N +ATOM 6519 CE2 TRP D 205 14.152 70.055 0.760 1.00 8.50 C +ATOM 6520 CE3 TRP D 205 13.208 68.870 2.638 1.00 8.50 C +ATOM 6521 CZ2 TRP D 205 13.222 69.501 -0.112 1.00 8.50 C +ATOM 6522 CZ3 TRP D 205 12.291 68.327 1.774 1.00 8.50 C +ATOM 6523 CH2 TRP D 205 12.299 68.642 0.416 1.00 8.50 C +ATOM 6524 N PRO D 206 16.708 73.282 5.421 1.00 28.74 N +ATOM 6525 CA PRO D 206 17.402 74.554 5.229 1.00 25.80 C +ATOM 6526 C PRO D 206 18.336 74.557 4.038 1.00 31.16 C +ATOM 6527 O PRO D 206 18.512 75.632 3.443 1.00 34.58 O +ATOM 6528 CB PRO D 206 18.173 74.698 6.523 1.00 31.39 C +ATOM 6529 CG PRO D 206 18.559 73.288 6.834 1.00 32.45 C +ATOM 6530 CD PRO D 206 17.262 72.549 6.575 1.00 39.67 C +ATOM 6531 OXT PRO D 206 18.903 73.495 3.731 1.00 40.14 O +TER 6532 PRO D 206 +ATOM 6533 N GLN E 1 -6.529 92.503 27.812 1.00 60.79 N +ATOM 6534 CA GLN E 1 -5.442 93.367 27.295 1.00 54.02 C +ATOM 6535 C GLN E 1 -4.332 93.367 28.337 1.00 52.17 C +ATOM 6536 O GLN E 1 -4.032 94.389 28.957 1.00 58.53 O +ATOM 6537 CB GLN E 1 -5.942 94.782 27.017 1.00 68.06 C +ATOM 6538 CG GLN E 1 -5.172 95.474 25.880 1.00 85.44 C +ATOM 6539 CD GLN E 1 -3.650 95.411 26.051 1.00 94.66 C +ATOM 6540 OE1 GLN E 1 -3.020 94.382 25.788 1.00 93.09 O +ATOM 6541 NE2 GLN E 1 -3.065 96.500 26.524 1.00106.18 N +ATOM 6542 N THR E 2 -3.743 92.199 28.545 1.00 42.25 N +ATOM 6543 CA THR E 2 -2.682 92.065 29.519 1.00 34.42 C +ATOM 6544 C THR E 2 -1.430 91.591 28.813 1.00 31.63 C +ATOM 6545 O THR E 2 -1.503 90.776 27.901 1.00 37.92 O +ATOM 6546 CB THR E 2 -3.073 91.049 30.589 1.00 27.39 C +ATOM 6547 OG1 THR E 2 -4.396 91.340 31.051 1.00 36.84 O +ATOM 6548 CG2 THR E 2 -2.109 91.100 31.758 1.00 36.82 C +ATOM 6549 N ASP E 3 -0.291 92.149 29.183 1.00 27.52 N +ATOM 6550 CA ASP E 3 0.957 91.735 28.580 1.00 22.86 C +ATOM 6551 C ASP E 3 1.409 90.517 29.363 1.00 25.10 C +ATOM 6552 O ASP E 3 1.979 90.636 30.447 1.00 27.63 O +ATOM 6553 CB ASP E 3 2.001 92.848 28.666 1.00 27.10 C +ATOM 6554 CG ASP E 3 3.148 92.640 27.711 1.00 28.31 C +ATOM 6555 OD1 ASP E 3 3.263 91.529 27.168 1.00 31.11 O +ATOM 6556 OD2 ASP E 3 3.924 93.592 27.487 1.00 39.72 O +ATOM 6557 N MET E 4 1.120 89.344 28.819 1.00 22.06 N +ATOM 6558 CA MET E 4 1.476 88.094 29.462 1.00 16.65 C +ATOM 6559 C MET E 4 2.931 87.678 29.264 1.00 15.08 C +ATOM 6560 O MET E 4 3.310 86.548 29.561 1.00 15.87 O +ATOM 6561 CB MET E 4 0.535 86.997 28.998 1.00 12.31 C +ATOM 6562 CG MET E 4 -0.869 87.132 29.553 1.00 13.72 C +ATOM 6563 SD MET E 4 -0.895 87.111 31.347 1.00 14.32 S +ATOM 6564 CE MET E 4 -0.727 85.398 31.684 1.00 8.50 C +ATOM 6565 N SER E 5 3.755 88.613 28.817 1.00 11.23 N +ATOM 6566 CA SER E 5 5.165 88.350 28.578 1.00 14.78 C +ATOM 6567 C SER E 5 5.893 87.809 29.789 1.00 15.27 C +ATOM 6568 O SER E 5 5.747 88.327 30.886 1.00 22.04 O +ATOM 6569 CB SER E 5 5.886 89.616 28.102 1.00 19.11 C +ATOM 6570 OG SER E 5 5.610 89.885 26.737 1.00 27.46 O +ATOM 6571 N ARG E 6 6.700 86.778 29.563 1.00 16.01 N +ATOM 6572 CA ARG E 6 7.495 86.160 30.616 1.00 15.10 C +ATOM 6573 C ARG E 6 6.659 85.426 31.651 1.00 15.03 C +ATOM 6574 O ARG E 6 7.182 85.017 32.685 1.00 17.79 O +ATOM 6575 CB ARG E 6 8.339 87.216 31.337 1.00 21.62 C +ATOM 6576 CG ARG E 6 9.831 87.074 31.137 1.00 34.87 C +ATOM 6577 CD ARG E 6 10.236 87.430 29.715 1.00 44.99 C +ATOM 6578 NE ARG E 6 11.220 86.495 29.175 1.00 57.96 N +ATOM 6579 CZ ARG E 6 12.409 86.245 29.717 1.00 67.39 C +ATOM 6580 NH1 ARG E 6 12.796 86.868 30.832 1.00 67.42 N +ATOM 6581 NH2 ARG E 6 13.190 85.321 29.166 1.00 77.51 N +ATOM 6582 N LYS E 7 5.377 85.237 31.364 1.00 13.29 N +ATOM 6583 CA LYS E 7 4.489 84.555 32.286 1.00 8.71 C +ATOM 6584 C LYS E 7 3.893 83.295 31.684 1.00 9.34 C +ATOM 6585 O LYS E 7 3.962 83.079 30.469 1.00 8.90 O +ATOM 6586 CB LYS E 7 3.396 85.514 32.749 1.00 12.01 C +ATOM 6587 CG LYS E 7 3.925 86.600 33.676 1.00 18.89 C +ATOM 6588 CD LYS E 7 2.972 87.770 33.770 1.00 35.19 C +ATOM 6589 CE LYS E 7 3.531 88.876 34.640 1.00 43.95 C +ATOM 6590 NZ LYS E 7 2.704 90.117 34.509 1.00 62.21 N +ATOM 6591 N ALA E 8 3.349 82.446 32.549 1.00 9.49 N +ATOM 6592 CA ALA E 8 2.730 81.184 32.144 1.00 8.50 C +ATOM 6593 C ALA E 8 1.584 80.878 33.086 1.00 8.50 C +ATOM 6594 O ALA E 8 1.605 81.292 34.234 1.00 11.98 O +ATOM 6595 CB ALA E 8 3.750 80.063 32.213 1.00 8.50 C +ATOM 6596 N PHE E 9 0.549 80.224 32.586 1.00 8.75 N +ATOM 6597 CA PHE E 9 -0.575 79.841 33.421 1.00 8.50 C +ATOM 6598 C PHE E 9 -0.145 78.499 33.959 1.00 8.50 C +ATOM 6599 O PHE E 9 0.396 77.689 33.209 1.00 9.23 O +ATOM 6600 CB PHE E 9 -1.846 79.633 32.592 1.00 14.31 C +ATOM 6601 CG PHE E 9 -2.446 80.903 32.031 1.00 16.66 C +ATOM 6602 CD1 PHE E 9 -2.883 81.922 32.879 1.00 8.50 C +ATOM 6603 CD2 PHE E 9 -2.613 81.053 30.651 1.00 9.68 C +ATOM 6604 CE1 PHE E 9 -3.472 83.056 32.362 1.00 9.86 C +ATOM 6605 CE2 PHE E 9 -3.201 82.185 30.130 1.00 10.60 C +ATOM 6606 CZ PHE E 9 -3.632 83.190 30.979 1.00 14.18 C +ATOM 6607 N VAL E 10 -0.367 78.256 35.246 1.00 10.59 N +ATOM 6608 CA VAL E 10 0.013 76.985 35.851 1.00 8.70 C +ATOM 6609 C VAL E 10 -1.141 76.300 36.592 1.00 9.58 C +ATOM 6610 O VAL E 10 -1.764 76.890 37.471 1.00 8.50 O +ATOM 6611 CB VAL E 10 1.296 77.134 36.728 1.00 8.50 C +ATOM 6612 CG1 VAL E 10 1.377 78.507 37.331 1.00 10.28 C +ATOM 6613 CG2 VAL E 10 1.340 76.095 37.816 1.00 8.50 C +ATOM 6614 N PHE E 11 -1.472 75.086 36.141 1.00 13.01 N +ATOM 6615 CA PHE E 11 -2.537 74.234 36.706 1.00 9.29 C +ATOM 6616 C PHE E 11 -1.812 73.187 37.543 1.00 11.50 C +ATOM 6617 O PHE E 11 -1.405 72.149 37.028 1.00 10.99 O +ATOM 6618 CB PHE E 11 -3.303 73.539 35.584 1.00 8.50 C +ATOM 6619 CG PHE E 11 -3.806 74.480 34.509 1.00 14.84 C +ATOM 6620 CD1 PHE E 11 -5.063 75.064 34.613 1.00 21.23 C +ATOM 6621 CD2 PHE E 11 -3.034 74.774 33.390 1.00 8.50 C +ATOM 6622 CE1 PHE E 11 -5.544 75.930 33.619 1.00 15.72 C +ATOM 6623 CE2 PHE E 11 -3.512 75.633 32.404 1.00 8.78 C +ATOM 6624 CZ PHE E 11 -4.765 76.211 32.518 1.00 8.50 C +ATOM 6625 N PRO E 12 -1.658 73.444 38.856 1.00 13.91 N +ATOM 6626 CA PRO E 12 -0.970 72.576 39.822 1.00 12.74 C +ATOM 6627 C PRO E 12 -1.545 71.208 40.081 1.00 20.90 C +ATOM 6628 O PRO E 12 -0.793 70.292 40.431 1.00 28.22 O +ATOM 6629 CB PRO E 12 -0.960 73.408 41.108 1.00 10.04 C +ATOM 6630 CG PRO E 12 -1.139 74.804 40.630 1.00 18.03 C +ATOM 6631 CD PRO E 12 -2.176 74.634 39.542 1.00 17.56 C +ATOM 6632 N LYS E 13 -2.867 71.063 39.986 1.00 30.54 N +ATOM 6633 CA LYS E 13 -3.470 69.752 40.242 1.00 36.32 C +ATOM 6634 C LYS E 13 -4.591 69.343 39.312 1.00 33.15 C +ATOM 6635 O LYS E 13 -5.224 70.196 38.683 1.00 31.36 O +ATOM 6636 CB LYS E 13 -3.892 69.592 41.720 1.00 42.47 C +ATOM 6637 CG LYS E 13 -4.644 70.760 42.357 1.00 41.26 C +ATOM 6638 CD LYS E 13 -4.791 70.498 43.852 1.00 53.36 C +ATOM 6639 CE LYS E 13 -5.384 71.681 44.603 1.00 66.33 C +ATOM 6640 NZ LYS E 13 -6.790 71.994 44.204 1.00 74.65 N +ATOM 6641 N GLU E 14 -4.805 68.030 39.234 1.00 32.84 N +ATOM 6642 CA GLU E 14 -5.828 67.450 38.376 1.00 41.69 C +ATOM 6643 C GLU E 14 -7.192 67.966 38.776 1.00 41.64 C +ATOM 6644 O GLU E 14 -7.622 67.809 39.914 1.00 42.98 O +ATOM 6645 CB GLU E 14 -5.798 65.912 38.419 1.00 47.07 C +ATOM 6646 CG GLU E 14 -6.695 65.230 37.361 1.00 48.70 C +ATOM 6647 CD GLU E 14 -6.580 63.712 37.352 1.00 49.58 C +ATOM 6648 OE1 GLU E 14 -5.494 63.200 37.010 1.00 52.11 O +ATOM 6649 OE2 GLU E 14 -7.579 63.030 37.671 1.00 46.24 O +ATOM 6650 N SER E 15 -7.859 68.612 37.833 1.00 44.91 N +ATOM 6651 CA SER E 15 -9.164 69.169 38.095 1.00 42.72 C +ATOM 6652 C SER E 15 -10.200 68.854 37.037 1.00 41.56 C +ATOM 6653 O SER E 15 -9.928 68.246 36.003 1.00 38.85 O +ATOM 6654 CB SER E 15 -9.065 70.680 38.318 1.00 46.80 C +ATOM 6655 OG SER E 15 -8.348 71.324 37.274 1.00 59.48 O +ATOM 6656 N ASP E 16 -11.416 69.247 37.365 1.00 44.36 N +ATOM 6657 CA ASP E 16 -12.596 69.053 36.550 1.00 46.06 C +ATOM 6658 C ASP E 16 -13.110 70.469 36.284 1.00 42.07 C +ATOM 6659 O ASP E 16 -13.853 70.713 35.340 1.00 41.77 O +ATOM 6660 CB ASP E 16 -13.621 68.286 37.419 1.00 56.72 C +ATOM 6661 CG ASP E 16 -14.653 67.510 36.611 1.00 67.65 C +ATOM 6662 OD1 ASP E 16 -14.383 67.147 35.445 1.00 80.03 O +ATOM 6663 OD2 ASP E 16 -15.734 67.229 37.173 1.00 64.90 O +ATOM 6664 N THR E 17 -12.622 71.404 37.093 1.00 40.16 N +ATOM 6665 CA THR E 17 -13.036 72.804 37.069 1.00 40.17 C +ATOM 6666 C THR E 17 -12.060 73.904 36.602 1.00 40.92 C +ATOM 6667 O THR E 17 -12.498 75.010 36.276 1.00 43.73 O +ATOM 6668 CB THR E 17 -13.505 73.189 38.482 1.00 45.65 C +ATOM 6669 OG1 THR E 17 -12.501 72.792 39.434 1.00 44.55 O +ATOM 6670 CG2 THR E 17 -14.814 72.482 38.821 1.00 48.67 C +ATOM 6671 N SER E 18 -10.755 73.634 36.615 1.00 36.49 N +ATOM 6672 CA SER E 18 -9.766 74.638 36.217 1.00 22.95 C +ATOM 6673 C SER E 18 -9.557 74.757 34.718 1.00 21.09 C +ATOM 6674 O SER E 18 -9.430 73.746 34.016 1.00 19.72 O +ATOM 6675 CB SER E 18 -8.423 74.370 36.895 1.00 22.26 C +ATOM 6676 OG SER E 18 -8.575 74.288 38.304 1.00 25.11 O +ATOM 6677 N TYR E 19 -9.535 76.002 34.241 1.00 16.66 N +ATOM 6678 CA TYR E 19 -9.325 76.324 32.826 1.00 14.44 C +ATOM 6679 C TYR E 19 -9.208 77.828 32.629 1.00 13.02 C +ATOM 6680 O TYR E 19 -9.530 78.598 33.525 1.00 14.08 O +ATOM 6681 CB TYR E 19 -10.457 75.778 31.947 1.00 11.29 C +ATOM 6682 CG TYR E 19 -11.789 76.456 32.107 1.00 16.72 C +ATOM 6683 CD1 TYR E 19 -12.113 77.586 31.359 1.00 21.98 C +ATOM 6684 CD2 TYR E 19 -12.742 75.953 32.982 1.00 25.69 C +ATOM 6685 CE1 TYR E 19 -13.360 78.201 31.476 1.00 29.79 C +ATOM 6686 CE2 TYR E 19 -13.994 76.559 33.109 1.00 35.51 C +ATOM 6687 CZ TYR E 19 -14.295 77.683 32.350 1.00 32.12 C +ATOM 6688 OH TYR E 19 -15.528 78.287 32.445 1.00 37.51 O +ATOM 6689 N VAL E 20 -8.710 78.238 31.469 1.00 14.47 N +ATOM 6690 CA VAL E 20 -8.554 79.647 31.127 1.00 8.50 C +ATOM 6691 C VAL E 20 -9.188 79.836 29.774 1.00 12.35 C +ATOM 6692 O VAL E 20 -8.870 79.119 28.832 1.00 13.19 O +ATOM 6693 CB VAL E 20 -7.095 80.063 31.017 1.00 8.50 C +ATOM 6694 CG1 VAL E 20 -6.997 81.485 30.572 1.00 8.50 C +ATOM 6695 CG2 VAL E 20 -6.407 79.899 32.335 1.00 12.58 C +ATOM 6696 N SER E 21 -10.116 80.777 29.697 1.00 18.49 N +ATOM 6697 CA SER E 21 -10.826 81.074 28.463 1.00 19.01 C +ATOM 6698 C SER E 21 -10.148 82.231 27.763 1.00 16.38 C +ATOM 6699 O SER E 21 -9.864 83.256 28.389 1.00 16.88 O +ATOM 6700 CB SER E 21 -12.285 81.437 28.757 1.00 26.92 C +ATOM 6701 OG SER E 21 -13.003 81.677 27.555 1.00 39.97 O +ATOM 6702 N LEU E 22 -9.868 82.047 26.475 1.00 11.95 N +ATOM 6703 CA LEU E 22 -9.224 83.061 25.662 1.00 11.21 C +ATOM 6704 C LEU E 22 -10.270 83.682 24.747 1.00 21.32 C +ATOM 6705 O LEU E 22 -11.040 82.964 24.094 1.00 23.30 O +ATOM 6706 CB LEU E 22 -8.098 82.441 24.848 1.00 8.50 C +ATOM 6707 CG LEU E 22 -6.665 82.533 25.382 1.00 8.50 C +ATOM 6708 CD1 LEU E 22 -6.594 82.331 26.871 1.00 8.50 C +ATOM 6709 CD2 LEU E 22 -5.808 81.526 24.651 1.00 8.50 C +ATOM 6710 N LYS E 23 -10.323 85.017 24.740 1.00 27.95 N +ATOM 6711 CA LYS E 23 -11.276 85.764 23.923 1.00 29.03 C +ATOM 6712 C LYS E 23 -10.619 86.324 22.673 1.00 32.87 C +ATOM 6713 O LYS E 23 -9.732 87.167 22.743 1.00 31.76 O +ATOM 6714 CB LYS E 23 -11.887 86.898 24.729 1.00 8.50 C +ATOM 6715 CG LYS E 23 -12.385 86.476 26.095 1.00 27.48 C +ATOM 6716 CD LYS E 23 -13.364 87.474 26.718 1.00 31.66 C +ATOM 6717 CE LYS E 23 -14.043 86.892 27.985 1.00 52.45 C +ATOM 6718 NZ LYS E 23 -14.825 85.602 27.774 1.00 46.35 N +ATOM 6719 N ALA E 24 -11.052 85.827 21.525 1.00 44.22 N +ATOM 6720 CA ALA E 24 -10.521 86.269 20.248 1.00 54.85 C +ATOM 6721 C ALA E 24 -11.592 87.077 19.531 1.00 64.88 C +ATOM 6722 O ALA E 24 -12.742 86.664 19.458 1.00 70.50 O +ATOM 6723 CB ALA E 24 -10.127 85.074 19.404 1.00 55.94 C +ATOM 6724 N PRO E 25 -11.242 88.269 19.051 1.00 71.69 N +ATOM 6725 CA PRO E 25 -12.188 89.131 18.339 1.00 76.11 C +ATOM 6726 C PRO E 25 -12.244 88.755 16.857 1.00 79.66 C +ATOM 6727 O PRO E 25 -11.835 89.514 15.973 1.00 80.92 O +ATOM 6728 CB PRO E 25 -11.608 90.519 18.565 1.00 82.48 C +ATOM 6729 CG PRO E 25 -10.170 90.267 18.599 1.00 83.82 C +ATOM 6730 CD PRO E 25 -9.988 88.977 19.349 1.00 75.19 C +ATOM 6731 N LEU E 26 -12.759 87.565 16.597 1.00 80.94 N +ATOM 6732 CA LEU E 26 -12.858 87.057 15.241 1.00 81.70 C +ATOM 6733 C LEU E 26 -14.168 87.463 14.569 1.00 84.90 C +ATOM 6734 O LEU E 26 -15.237 87.450 15.190 1.00 84.49 O +ATOM 6735 CB LEU E 26 -12.694 85.538 15.262 1.00 81.19 C +ATOM 6736 CG LEU E 26 -11.744 84.908 14.244 1.00 75.95 C +ATOM 6737 CD1 LEU E 26 -10.515 85.788 14.030 1.00 74.42 C +ATOM 6738 CD2 LEU E 26 -11.350 83.527 14.742 1.00 70.27 C +ATOM 6739 N THR E 27 -14.059 87.857 13.302 1.00 88.41 N +ATOM 6740 CA THR E 27 -15.207 88.286 12.495 1.00 88.04 C +ATOM 6741 C THR E 27 -15.378 87.391 11.268 1.00 82.38 C +ATOM 6742 O THR E 27 -16.489 86.962 10.951 1.00 81.93 O +ATOM 6743 CB THR E 27 -15.034 89.751 12.016 1.00 90.15 C +ATOM 6744 OG1 THR E 27 -13.723 89.923 11.452 1.00 90.28 O +ATOM 6745 CG2 THR E 27 -15.214 90.721 13.177 1.00 95.93 C +ATOM 6746 N LYS E 28 -14.271 87.152 10.564 1.00 77.22 N +ATOM 6747 CA LYS E 28 -14.256 86.309 9.368 1.00 70.72 C +ATOM 6748 C LYS E 28 -13.922 84.879 9.760 1.00 60.08 C +ATOM 6749 O LYS E 28 -13.157 84.660 10.697 1.00 65.70 O +ATOM 6750 CB LYS E 28 -13.184 86.803 8.379 1.00 79.78 C +ATOM 6751 CG LYS E 28 -13.560 88.029 7.545 1.00 88.69 C +ATOM 6752 CD LYS E 28 -14.517 87.671 6.417 1.00 97.03 C +ATOM 6753 CE LYS E 28 -14.839 88.880 5.544 1.00100.83 C +ATOM 6754 NZ LYS E 28 -15.711 88.509 4.392 1.00103.95 N +ATOM 6755 N PRO E 29 -14.555 83.892 9.109 1.00 48.23 N +ATOM 6756 CA PRO E 29 -14.283 82.484 9.409 1.00 44.05 C +ATOM 6757 C PRO E 29 -12.896 82.108 8.858 1.00 38.28 C +ATOM 6758 O PRO E 29 -12.470 82.639 7.826 1.00 37.51 O +ATOM 6759 CB PRO E 29 -15.422 81.757 8.691 1.00 42.42 C +ATOM 6760 CG PRO E 29 -15.728 82.649 7.550 1.00 48.53 C +ATOM 6761 CD PRO E 29 -15.699 84.013 8.193 1.00 49.50 C +ATOM 6762 N LEU E 30 -12.190 81.217 9.555 1.00 29.55 N +ATOM 6763 CA LEU E 30 -10.839 80.819 9.154 1.00 22.61 C +ATOM 6764 C LEU E 30 -10.720 79.865 7.962 1.00 19.55 C +ATOM 6765 O LEU E 30 -11.370 78.821 7.910 1.00 12.62 O +ATOM 6766 CB LEU E 30 -10.060 80.236 10.342 1.00 20.19 C +ATOM 6767 CG LEU E 30 -9.662 81.073 11.559 1.00 12.29 C +ATOM 6768 CD1 LEU E 30 -9.706 82.558 11.239 1.00 9.49 C +ATOM 6769 CD2 LEU E 30 -10.573 80.745 12.719 1.00 16.23 C +ATOM 6770 N LYS E 31 -9.841 80.229 7.035 1.00 15.75 N +ATOM 6771 CA LYS E 31 -9.558 79.440 5.843 1.00 15.52 C +ATOM 6772 C LYS E 31 -8.144 78.864 5.934 1.00 16.47 C +ATOM 6773 O LYS E 31 -7.675 78.168 5.029 1.00 12.89 O +ATOM 6774 CB LYS E 31 -9.670 80.323 4.602 1.00 24.85 C +ATOM 6775 CG LYS E 31 -11.094 80.569 4.124 1.00 43.72 C +ATOM 6776 CD LYS E 31 -11.715 79.283 3.584 1.00 60.81 C +ATOM 6777 CE LYS E 31 -13.170 79.465 3.174 1.00 68.60 C +ATOM 6778 NZ LYS E 31 -13.759 78.187 2.670 1.00 79.56 N +ATOM 6779 N ALA E 32 -7.462 79.217 7.021 1.00 20.12 N +ATOM 6780 CA ALA E 32 -6.099 78.790 7.339 1.00 10.68 C +ATOM 6781 C ALA E 32 -5.793 79.338 8.733 1.00 8.61 C +ATOM 6782 O ALA E 32 -6.539 80.171 9.237 1.00 12.71 O +ATOM 6783 CB ALA E 32 -5.128 79.351 6.332 1.00 8.50 C +ATOM 6784 N PHE E 33 -4.742 78.845 9.374 1.00 8.50 N +ATOM 6785 CA PHE E 33 -4.356 79.328 10.689 1.00 8.50 C +ATOM 6786 C PHE E 33 -3.043 78.717 11.143 1.00 9.69 C +ATOM 6787 O PHE E 33 -2.612 77.727 10.594 1.00 12.85 O +ATOM 6788 CB PHE E 33 -5.445 79.047 11.721 1.00 8.50 C +ATOM 6789 CG PHE E 33 -5.688 77.588 11.974 1.00 9.63 C +ATOM 6790 CD1 PHE E 33 -4.992 76.908 12.957 1.00 10.19 C +ATOM 6791 CD2 PHE E 33 -6.643 76.898 11.254 1.00 19.75 C +ATOM 6792 CE1 PHE E 33 -5.240 75.579 13.220 1.00 8.50 C +ATOM 6793 CE2 PHE E 33 -6.896 75.554 11.519 1.00 13.10 C +ATOM 6794 CZ PHE E 33 -6.190 74.906 12.501 1.00 8.50 C +ATOM 6795 N THR E 34 -2.387 79.349 12.111 1.00 11.42 N +ATOM 6796 CA THR E 34 -1.137 78.860 12.690 1.00 8.50 C +ATOM 6797 C THR E 34 -1.280 79.167 14.160 1.00 8.50 C +ATOM 6798 O THR E 34 -1.664 80.282 14.518 1.00 12.41 O +ATOM 6799 CB THR E 34 0.100 79.626 12.217 1.00 8.50 C +ATOM 6800 OG1 THR E 34 0.180 79.600 10.794 1.00 9.48 O +ATOM 6801 CG2 THR E 34 1.359 79.023 12.799 1.00 8.50 C +ATOM 6802 N VAL E 35 -1.073 78.169 15.004 1.00 8.50 N +ATOM 6803 CA VAL E 35 -1.152 78.368 16.434 1.00 8.50 C +ATOM 6804 C VAL E 35 0.094 77.785 17.053 1.00 9.76 C +ATOM 6805 O VAL E 35 0.450 76.653 16.757 1.00 13.53 O +ATOM 6806 CB VAL E 35 -2.452 77.797 17.052 1.00 8.50 C +ATOM 6807 CG1 VAL E 35 -3.086 76.811 16.146 1.00 8.50 C +ATOM 6808 CG2 VAL E 35 -2.186 77.218 18.417 1.00 8.50 C +ATOM 6809 N CYS E 36 0.810 78.600 17.824 1.00 8.55 N +ATOM 6810 CA CYS E 36 2.039 78.183 18.480 1.00 8.50 C +ATOM 6811 C CYS E 36 1.853 78.356 19.965 1.00 8.50 C +ATOM 6812 O CYS E 36 1.066 79.187 20.381 1.00 10.56 O +ATOM 6813 CB CYS E 36 3.205 79.024 18.016 1.00 8.50 C +ATOM 6814 SG CYS E 36 3.527 78.930 16.226 1.00 8.50 S +ATOM 6815 N LEU E 37 2.525 77.530 20.759 1.00 8.50 N +ATOM 6816 CA LEU E 37 2.431 77.590 22.205 1.00 8.50 C +ATOM 6817 C LEU E 37 3.551 76.821 22.871 1.00 8.50 C +ATOM 6818 O LEU E 37 4.247 76.053 22.229 1.00 10.27 O +ATOM 6819 CB LEU E 37 1.063 77.095 22.687 1.00 8.50 C +ATOM 6820 CG LEU E 37 0.610 75.677 22.387 1.00 8.50 C +ATOM 6821 CD1 LEU E 37 1.056 74.749 23.482 1.00 8.50 C +ATOM 6822 CD2 LEU E 37 -0.883 75.674 22.294 1.00 11.37 C +ATOM 6823 N HIS E 38 3.742 77.057 24.160 1.00 8.50 N +ATOM 6824 CA HIS E 38 4.781 76.412 24.949 1.00 8.50 C +ATOM 6825 C HIS E 38 4.055 75.703 26.080 1.00 12.38 C +ATOM 6826 O HIS E 38 3.196 76.313 26.716 1.00 21.30 O +ATOM 6827 CB HIS E 38 5.648 77.489 25.569 1.00 8.50 C +ATOM 6828 CG HIS E 38 7.087 77.429 25.179 1.00 8.50 C +ATOM 6829 ND1 HIS E 38 7.729 78.472 24.555 1.00 8.50 N +ATOM 6830 CD2 HIS E 38 8.035 76.488 25.398 1.00 18.27 C +ATOM 6831 CE1 HIS E 38 9.010 78.181 24.404 1.00 14.07 C +ATOM 6832 NE2 HIS E 38 9.222 76.981 24.909 1.00 13.73 N +ATOM 6833 N PHE E 39 4.350 74.431 26.324 1.00 8.50 N +ATOM 6834 CA PHE E 39 3.700 73.742 27.425 1.00 8.50 C +ATOM 6835 C PHE E 39 4.721 72.874 28.124 1.00 9.55 C +ATOM 6836 O PHE E 39 5.769 72.573 27.555 1.00 12.21 O +ATOM 6837 CB PHE E 39 2.469 72.950 26.974 1.00 8.50 C +ATOM 6838 CG PHE E 39 2.780 71.704 26.217 1.00 8.50 C +ATOM 6839 CD1 PHE E 39 3.000 71.749 24.858 1.00 9.08 C +ATOM 6840 CD2 PHE E 39 2.838 70.479 26.866 1.00 10.46 C +ATOM 6841 CE1 PHE E 39 3.271 70.598 24.150 1.00 11.10 C +ATOM 6842 CE2 PHE E 39 3.110 69.326 26.173 1.00 13.76 C +ATOM 6843 CZ PHE E 39 3.328 69.384 24.807 1.00 15.57 C +ATOM 6844 N TYR E 40 4.450 72.521 29.376 1.00 8.50 N +ATOM 6845 CA TYR E 40 5.382 71.708 30.143 1.00 10.96 C +ATOM 6846 C TYR E 40 4.603 70.879 31.152 1.00 12.39 C +ATOM 6847 O TYR E 40 4.115 71.420 32.137 1.00 11.92 O +ATOM 6848 CB TYR E 40 6.360 72.619 30.881 1.00 8.50 C +ATOM 6849 CG TYR E 40 7.394 71.900 31.690 1.00 8.50 C +ATOM 6850 CD1 TYR E 40 7.760 70.607 31.381 1.00 8.50 C +ATOM 6851 CD2 TYR E 40 8.020 72.523 32.753 1.00 8.50 C +ATOM 6852 CE1 TYR E 40 8.723 69.944 32.109 1.00 13.10 C +ATOM 6853 CE2 TYR E 40 8.991 71.873 33.492 1.00 11.27 C +ATOM 6854 CZ TYR E 40 9.336 70.581 33.162 1.00 11.02 C +ATOM 6855 OH TYR E 40 10.306 69.914 33.850 1.00 10.87 O +ATOM 6856 N THR E 41 4.502 69.570 30.911 1.00 13.07 N +ATOM 6857 CA THR E 41 3.767 68.671 31.790 1.00 9.45 C +ATOM 6858 C THR E 41 4.464 67.335 31.990 1.00 14.42 C +ATOM 6859 O THR E 41 5.358 66.958 31.234 1.00 16.88 O +ATOM 6860 CB THR E 41 2.349 68.423 31.273 1.00 8.50 C +ATOM 6861 OG1 THR E 41 1.639 67.622 32.222 1.00 11.98 O +ATOM 6862 CG2 THR E 41 2.382 67.703 29.938 1.00 13.22 C +ATOM 6863 N GLU E 42 4.006 66.592 32.984 1.00 19.38 N +ATOM 6864 CA GLU E 42 4.602 65.295 33.303 1.00 28.05 C +ATOM 6865 C GLU E 42 3.618 64.135 33.038 1.00 28.77 C +ATOM 6866 O GLU E 42 3.862 62.994 33.410 1.00 34.22 O +ATOM 6867 CB GLU E 42 5.009 65.303 34.777 1.00 36.56 C +ATOM 6868 CG GLU E 42 6.317 64.611 35.105 1.00 42.44 C +ATOM 6869 CD GLU E 42 6.828 64.968 36.497 1.00 48.36 C +ATOM 6870 OE1 GLU E 42 6.443 64.312 37.499 1.00 54.11 O +ATOM 6871 OE2 GLU E 42 7.619 65.922 36.580 1.00 43.18 O +ATOM 6872 N LEU E 43 2.440 64.468 32.524 1.00 21.95 N +ATOM 6873 CA LEU E 43 1.405 63.482 32.247 1.00 10.47 C +ATOM 6874 C LEU E 43 1.717 62.549 31.092 1.00 14.10 C +ATOM 6875 O LEU E 43 1.243 61.437 31.076 1.00 21.48 O +ATOM 6876 CB LEU E 43 0.077 64.178 31.929 1.00 10.25 C +ATOM 6877 CG LEU E 43 -0.965 64.593 32.959 1.00 8.50 C +ATOM 6878 CD1 LEU E 43 -0.319 64.892 34.296 1.00 21.56 C +ATOM 6879 CD2 LEU E 43 -1.711 65.805 32.416 1.00 13.09 C +ATOM 6880 N SER E 44 2.445 63.032 30.094 1.00 24.61 N +ATOM 6881 CA SER E 44 2.796 62.277 28.880 1.00 25.62 C +ATOM 6882 C SER E 44 2.954 60.763 29.021 1.00 29.38 C +ATOM 6883 O SER E 44 2.538 59.999 28.138 1.00 23.63 O +ATOM 6884 CB SER E 44 4.078 62.875 28.262 1.00 33.93 C +ATOM 6885 OG SER E 44 4.017 64.298 28.154 1.00 39.28 O +ATOM 6886 N SER E 45 3.541 60.349 30.149 1.00 41.78 N +ATOM 6887 CA SER E 45 3.823 58.939 30.464 1.00 44.51 C +ATOM 6888 C SER E 45 2.675 58.115 31.066 1.00 39.72 C +ATOM 6889 O SER E 45 2.776 56.896 31.149 1.00 42.78 O +ATOM 6890 CB SER E 45 5.028 58.856 31.409 1.00 44.61 C +ATOM 6891 OG SER E 45 6.095 59.663 30.946 1.00 66.86 O +ATOM 6892 N THR E 46 1.601 58.770 31.497 1.00 35.59 N +ATOM 6893 CA THR E 46 0.485 58.072 32.113 1.00 27.24 C +ATOM 6894 C THR E 46 -0.881 58.245 31.453 1.00 26.59 C +ATOM 6895 O THR E 46 -1.579 57.248 31.244 1.00 36.30 O +ATOM 6896 CB THR E 46 0.382 58.413 33.629 1.00 30.71 C +ATOM 6897 OG1 THR E 46 -0.328 59.639 33.813 1.00 28.77 O +ATOM 6898 CG2 THR E 46 1.782 58.563 34.257 1.00 29.25 C +ATOM 6899 N ARG E 47 -1.292 59.483 31.156 1.00 21.47 N +ATOM 6900 CA ARG E 47 -2.596 59.715 30.501 1.00 20.38 C +ATOM 6901 C ARG E 47 -2.567 60.708 29.348 1.00 13.16 C +ATOM 6902 O ARG E 47 -1.511 61.243 29.025 1.00 21.29 O +ATOM 6903 CB ARG E 47 -3.675 60.122 31.504 1.00 13.20 C +ATOM 6904 CG ARG E 47 -3.532 61.485 32.086 1.00 17.00 C +ATOM 6905 CD ARG E 47 -4.694 61.748 33.024 1.00 19.25 C +ATOM 6906 NE ARG E 47 -4.621 63.048 33.695 1.00 24.41 N +ATOM 6907 CZ ARG E 47 -5.073 64.192 33.184 1.00 29.50 C +ATOM 6908 NH1 ARG E 47 -5.629 64.217 31.976 1.00 31.33 N +ATOM 6909 NH2 ARG E 47 -5.012 65.308 33.902 1.00 32.97 N +ATOM 6910 N GLY E 48 -3.705 60.879 28.685 1.00 8.50 N +ATOM 6911 CA GLY E 48 -3.783 61.812 27.579 1.00 13.51 C +ATOM 6912 C GLY E 48 -4.222 63.133 28.158 1.00 16.31 C +ATOM 6913 O GLY E 48 -4.700 63.143 29.294 1.00 20.91 O +ATOM 6914 N TYR E 49 -4.073 64.232 27.414 1.00 13.54 N +ATOM 6915 CA TYR E 49 -4.478 65.552 27.913 1.00 13.77 C +ATOM 6916 C TYR E 49 -4.697 66.548 26.780 1.00 20.43 C +ATOM 6917 O TYR E 49 -4.132 66.384 25.684 1.00 24.09 O +ATOM 6918 CB TYR E 49 -3.445 66.106 28.896 1.00 8.50 C +ATOM 6919 CG TYR E 49 -2.030 66.073 28.374 1.00 8.50 C +ATOM 6920 CD1 TYR E 49 -1.562 67.040 27.504 1.00 14.62 C +ATOM 6921 CD2 TYR E 49 -1.155 65.070 28.756 1.00 8.50 C +ATOM 6922 CE1 TYR E 49 -0.248 67.001 27.031 1.00 20.87 C +ATOM 6923 CE2 TYR E 49 0.140 65.025 28.292 1.00 8.50 C +ATOM 6924 CZ TYR E 49 0.595 65.987 27.435 1.00 8.50 C +ATOM 6925 OH TYR E 49 1.900 65.936 26.990 1.00 9.62 O +ATOM 6926 N SER E 50 -5.509 67.575 27.045 1.00 18.46 N +ATOM 6927 CA SER E 50 -5.805 68.589 26.044 1.00 20.83 C +ATOM 6928 C SER E 50 -4.856 69.765 26.156 1.00 23.96 C +ATOM 6929 O SER E 50 -4.666 70.335 27.238 1.00 31.50 O +ATOM 6930 CB SER E 50 -7.254 69.063 26.184 1.00 27.37 C +ATOM 6931 OG SER E 50 -7.554 70.113 25.277 1.00 36.70 O +ATOM 6932 N ILE E 51 -4.259 70.122 25.030 1.00 20.16 N +ATOM 6933 CA ILE E 51 -3.346 71.253 24.984 1.00 16.87 C +ATOM 6934 C ILE E 51 -4.072 72.555 24.557 1.00 18.16 C +ATOM 6935 O ILE E 51 -4.045 73.547 25.277 1.00 19.79 O +ATOM 6936 CB ILE E 51 -2.175 70.956 24.039 1.00 8.50 C +ATOM 6937 CG1 ILE E 51 -1.398 69.752 24.548 1.00 9.88 C +ATOM 6938 CG2 ILE E 51 -1.260 72.144 23.953 1.00 8.50 C +ATOM 6939 CD1 ILE E 51 -0.315 69.291 23.616 1.00 8.50 C +ATOM 6940 N PHE E 52 -4.776 72.509 23.426 1.00 14.14 N +ATOM 6941 CA PHE E 52 -5.496 73.649 22.886 1.00 8.50 C +ATOM 6942 C PHE E 52 -6.851 73.180 22.369 1.00 11.87 C +ATOM 6943 O PHE E 52 -6.905 72.303 21.524 1.00 13.15 O +ATOM 6944 CB PHE E 52 -4.687 74.226 21.731 1.00 8.50 C +ATOM 6945 CG PHE E 52 -5.210 75.544 21.199 1.00 16.20 C +ATOM 6946 CD1 PHE E 52 -5.057 76.723 21.927 1.00 16.19 C +ATOM 6947 CD2 PHE E 52 -5.814 75.616 19.956 1.00 8.88 C +ATOM 6948 CE1 PHE E 52 -5.494 77.925 21.416 1.00 8.50 C +ATOM 6949 CE2 PHE E 52 -6.249 76.817 19.453 1.00 8.50 C +ATOM 6950 CZ PHE E 52 -6.087 77.963 20.179 1.00 8.50 C +ATOM 6951 N SER E 53 -7.936 73.773 22.862 1.00 17.07 N +ATOM 6952 CA SER E 53 -9.304 73.407 22.452 1.00 16.58 C +ATOM 6953 C SER E 53 -10.120 74.588 21.895 1.00 12.95 C +ATOM 6954 O SER E 53 -10.564 75.451 22.649 1.00 10.89 O +ATOM 6955 CB SER E 53 -10.076 72.782 23.633 1.00 16.03 C +ATOM 6956 OG SER E 53 -11.321 72.226 23.217 1.00 15.38 O +ATOM 6957 N TYR E 54 -10.337 74.592 20.582 1.00 11.02 N +ATOM 6958 CA TYR E 54 -11.095 75.629 19.893 1.00 12.21 C +ATOM 6959 C TYR E 54 -12.423 75.011 19.502 1.00 20.95 C +ATOM 6960 O TYR E 54 -12.481 74.171 18.607 1.00 24.39 O +ATOM 6961 CB TYR E 54 -10.329 76.059 18.647 1.00 12.23 C +ATOM 6962 CG TYR E 54 -10.890 77.233 17.862 1.00 14.57 C +ATOM 6963 CD1 TYR E 54 -11.875 77.050 16.891 1.00 15.67 C +ATOM 6964 CD2 TYR E 54 -10.371 78.513 18.030 1.00 11.38 C +ATOM 6965 CE1 TYR E 54 -12.318 78.100 16.103 1.00 8.50 C +ATOM 6966 CE2 TYR E 54 -10.807 79.563 17.250 1.00 15.69 C +ATOM 6967 CZ TYR E 54 -11.780 79.348 16.288 1.00 13.77 C +ATOM 6968 OH TYR E 54 -12.200 80.382 15.497 1.00 19.21 O +ATOM 6969 N ALA E 55 -13.493 75.448 20.151 1.00 29.55 N +ATOM 6970 CA ALA E 55 -14.817 74.900 19.891 1.00 33.87 C +ATOM 6971 C ALA E 55 -15.858 75.884 19.366 1.00 35.12 C +ATOM 6972 O ALA E 55 -15.838 77.064 19.711 1.00 33.99 O +ATOM 6973 CB ALA E 55 -15.342 74.235 21.153 1.00 36.69 C +ATOM 6974 N THR E 56 -16.791 75.359 18.573 1.00 38.69 N +ATOM 6975 CA THR E 56 -17.895 76.125 17.987 1.00 41.95 C +ATOM 6976 C THR E 56 -19.192 75.513 18.518 1.00 45.54 C +ATOM 6977 O THR E 56 -19.189 74.400 19.063 1.00 44.00 O +ATOM 6978 CB THR E 56 -17.953 75.992 16.438 1.00 39.34 C +ATOM 6979 OG1 THR E 56 -16.632 76.042 15.888 1.00 32.07 O +ATOM 6980 CG2 THR E 56 -18.800 77.113 15.839 1.00 43.88 C +ATOM 6981 N LYS E 57 -20.297 76.232 18.332 1.00 49.22 N +ATOM 6982 CA LYS E 57 -21.603 75.750 18.770 1.00 50.65 C +ATOM 6983 C LYS E 57 -21.946 74.481 17.998 1.00 50.11 C +ATOM 6984 O LYS E 57 -22.413 73.489 18.568 1.00 52.82 O +ATOM 6985 CB LYS E 57 -22.667 76.808 18.499 1.00 50.36 C +ATOM 6986 CG LYS E 57 -22.417 78.160 19.159 1.00 42.19 C +ATOM 6987 CD LYS E 57 -23.678 78.983 19.118 1.00 41.90 C +ATOM 6988 CE LYS E 57 -24.852 78.167 19.684 1.00 56.88 C +ATOM 6989 NZ LYS E 57 -26.204 78.695 19.308 1.00 66.17 N +ATOM 6990 N ARG E 58 -21.650 74.519 16.702 1.00 49.46 N +ATOM 6991 CA ARG E 58 -21.919 73.404 15.792 1.00 50.10 C +ATOM 6992 C ARG E 58 -20.920 72.231 15.913 1.00 44.77 C +ATOM 6993 O ARG E 58 -21.304 71.065 15.807 1.00 42.29 O +ATOM 6994 CB ARG E 58 -21.987 73.922 14.336 1.00 71.15 C +ATOM 6995 CG ARG E 58 -22.744 75.274 14.120 1.00 71.35 C +ATOM 6996 CD ARG E 58 -24.278 75.247 14.392 1.00 71.55 C +ATOM 6997 NE ARG E 58 -25.089 74.633 13.323 1.00 79.19 N +ATOM 6998 CZ ARG E 58 -25.505 75.247 12.210 1.00 73.24 C +ATOM 6999 NH1 ARG E 58 -25.192 76.514 11.980 1.00 76.37 N +ATOM 7000 NH2 ARG E 58 -26.268 74.596 11.330 1.00 70.60 N +ATOM 7001 N GLN E 59 -19.650 72.549 16.141 1.00 42.14 N +ATOM 7002 CA GLN E 59 -18.599 71.543 16.249 1.00 33.19 C +ATOM 7003 C GLN E 59 -17.748 71.812 17.489 1.00 31.58 C +ATOM 7004 O GLN E 59 -17.037 72.814 17.546 1.00 36.05 O +ATOM 7005 CB GLN E 59 -17.739 71.591 14.976 1.00 28.97 C +ATOM 7006 CG GLN E 59 -16.468 70.764 15.009 1.00 29.58 C +ATOM 7007 CD GLN E 59 -16.724 69.289 15.249 1.00 34.92 C +ATOM 7008 OE1 GLN E 59 -16.843 68.849 16.398 1.00 41.91 O +ATOM 7009 NE2 GLN E 59 -16.792 68.513 14.173 1.00 27.94 N +ATOM 7010 N ASP E 60 -17.810 70.910 18.467 1.00 31.01 N +ATOM 7011 CA ASP E 60 -17.059 71.065 19.722 1.00 30.55 C +ATOM 7012 C ASP E 60 -15.548 70.938 19.558 1.00 25.90 C +ATOM 7013 O ASP E 60 -14.780 71.490 20.348 1.00 26.88 O +ATOM 7014 CB ASP E 60 -17.556 70.083 20.789 1.00 38.74 C +ATOM 7015 CG ASP E 60 -17.395 68.617 20.375 1.00 45.85 C +ATOM 7016 OD1 ASP E 60 -17.856 68.243 19.267 1.00 50.14 O +ATOM 7017 OD2 ASP E 60 -16.822 67.833 21.175 1.00 41.56 O +ATOM 7018 N ASN E 61 -15.116 70.209 18.537 1.00 18.45 N +ATOM 7019 CA ASN E 61 -13.694 70.038 18.299 1.00 9.63 C +ATOM 7020 C ASN E 61 -13.337 70.625 16.953 1.00 15.19 C +ATOM 7021 O ASN E 61 -12.934 69.885 16.041 1.00 17.97 O +ATOM 7022 CB ASN E 61 -13.318 68.566 18.341 1.00 8.50 C +ATOM 7023 CG ASN E 61 -13.464 67.966 19.729 1.00 35.28 C +ATOM 7024 OD1 ASN E 61 -13.667 66.749 19.877 1.00 43.72 O +ATOM 7025 ND2 ASN E 61 -13.383 68.816 20.762 1.00 42.04 N +ATOM 7026 N GLU E 62 -13.504 71.952 16.818 1.00 15.72 N +ATOM 7027 CA GLU E 62 -13.217 72.662 15.568 1.00 10.28 C +ATOM 7028 C GLU E 62 -11.732 72.575 15.240 1.00 12.40 C +ATOM 7029 O GLU E 62 -11.354 72.345 14.093 1.00 17.45 O +ATOM 7030 CB GLU E 62 -13.694 74.105 15.648 1.00 8.50 C +ATOM 7031 CG GLU E 62 -13.775 74.813 14.298 1.00 14.96 C +ATOM 7032 CD GLU E 62 -14.837 74.234 13.369 1.00 22.00 C +ATOM 7033 OE1 GLU E 62 -14.784 73.029 13.070 1.00 12.59 O +ATOM 7034 OE2 GLU E 62 -15.730 74.989 12.921 1.00 35.76 O +ATOM 7035 N ILE E 63 -10.898 72.818 16.238 1.00 11.23 N +ATOM 7036 CA ILE E 63 -9.452 72.700 16.090 1.00 12.19 C +ATOM 7037 C ILE E 63 -9.014 72.313 17.497 1.00 12.06 C +ATOM 7038 O ILE E 63 -9.391 72.969 18.474 1.00 12.54 O +ATOM 7039 CB ILE E 63 -8.727 74.009 15.489 1.00 11.66 C +ATOM 7040 CG1 ILE E 63 -7.480 74.374 16.279 1.00 9.23 C +ATOM 7041 CG2 ILE E 63 -9.653 75.199 15.347 1.00 8.50 C +ATOM 7042 CD1 ILE E 63 -6.332 73.438 16.047 1.00 17.84 C +ATOM 7043 N LEU E 64 -8.331 71.174 17.609 1.00 12.25 N +ATOM 7044 CA LEU E 64 -7.875 70.670 18.902 1.00 12.06 C +ATOM 7045 C LEU E 64 -6.504 69.984 18.841 1.00 13.69 C +ATOM 7046 O LEU E 64 -6.256 69.167 17.960 1.00 13.46 O +ATOM 7047 CB LEU E 64 -8.927 69.717 19.465 1.00 8.50 C +ATOM 7048 CG LEU E 64 -8.562 68.857 20.666 1.00 8.96 C +ATOM 7049 CD1 LEU E 64 -9.391 69.235 21.856 1.00 13.91 C +ATOM 7050 CD2 LEU E 64 -8.806 67.420 20.323 1.00 14.13 C +ATOM 7051 N ILE E 65 -5.616 70.364 19.758 1.00 10.46 N +ATOM 7052 CA ILE E 65 -4.281 69.792 19.863 1.00 10.15 C +ATOM 7053 C ILE E 65 -4.309 68.953 21.138 1.00 12.89 C +ATOM 7054 O ILE E 65 -4.580 69.460 22.232 1.00 9.29 O +ATOM 7055 CB ILE E 65 -3.212 70.875 19.963 1.00 8.50 C +ATOM 7056 CG1 ILE E 65 -3.266 71.754 18.728 1.00 8.50 C +ATOM 7057 CG2 ILE E 65 -1.845 70.248 20.122 1.00 8.50 C +ATOM 7058 CD1 ILE E 65 -2.459 72.994 18.854 1.00 10.84 C +ATOM 7059 N PHE E 66 -3.985 67.676 21.001 1.00 12.59 N +ATOM 7060 CA PHE E 66 -4.062 66.755 22.121 1.00 13.95 C +ATOM 7061 C PHE E 66 -2.895 65.783 22.135 1.00 12.47 C +ATOM 7062 O PHE E 66 -2.358 65.445 21.086 1.00 10.93 O +ATOM 7063 CB PHE E 66 -5.369 65.966 21.944 1.00 24.17 C +ATOM 7064 CG PHE E 66 -5.780 65.146 23.130 1.00 34.46 C +ATOM 7065 CD1 PHE E 66 -5.344 63.834 23.270 1.00 42.24 C +ATOM 7066 CD2 PHE E 66 -6.649 65.670 24.081 1.00 37.34 C +ATOM 7067 CE1 PHE E 66 -5.767 63.053 24.338 1.00 47.75 C +ATOM 7068 CE2 PHE E 66 -7.080 64.906 25.151 1.00 36.17 C +ATOM 7069 CZ PHE E 66 -6.639 63.593 25.281 1.00 49.94 C +ATOM 7070 N TRP E 67 -2.505 65.327 23.320 1.00 8.50 N +ATOM 7071 CA TRP E 67 -1.445 64.331 23.419 1.00 15.95 C +ATOM 7072 C TRP E 67 -2.136 63.029 23.832 1.00 22.64 C +ATOM 7073 O TRP E 67 -2.695 62.948 24.931 1.00 29.03 O +ATOM 7074 CB TRP E 67 -0.415 64.708 24.475 1.00 14.12 C +ATOM 7075 CG TRP E 67 0.484 63.556 24.851 1.00 13.99 C +ATOM 7076 CD1 TRP E 67 0.311 62.681 25.879 1.00 12.12 C +ATOM 7077 CD2 TRP E 67 1.676 63.151 24.179 1.00 13.66 C +ATOM 7078 NE1 TRP E 67 1.320 61.752 25.885 1.00 23.35 N +ATOM 7079 CE2 TRP E 67 2.171 62.022 24.849 1.00 20.89 C +ATOM 7080 CE3 TRP E 67 2.374 63.635 23.072 1.00 15.24 C +ATOM 7081 CZ2 TRP E 67 3.338 61.370 24.445 1.00 28.60 C +ATOM 7082 CZ3 TRP E 67 3.532 62.989 22.673 1.00 12.11 C +ATOM 7083 CH2 TRP E 67 4.003 61.872 23.354 1.00 15.59 C +ATOM 7084 N SER E 68 -2.166 62.040 22.944 1.00 20.23 N +ATOM 7085 CA SER E 68 -2.807 60.777 23.281 1.00 18.25 C +ATOM 7086 C SER E 68 -1.732 59.774 23.708 1.00 21.40 C +ATOM 7087 O SER E 68 -0.831 59.414 22.934 1.00 18.40 O +ATOM 7088 CB SER E 68 -3.682 60.258 22.135 1.00 8.98 C +ATOM 7089 OG SER E 68 -2.909 59.868 21.015 1.00 22.02 O +ATOM 7090 N LYS E 69 -1.809 59.397 24.984 1.00 25.48 N +ATOM 7091 CA LYS E 69 -0.877 58.490 25.648 1.00 23.81 C +ATOM 7092 C LYS E 69 -0.411 57.363 24.742 1.00 24.53 C +ATOM 7093 O LYS E 69 -1.218 56.787 24.012 1.00 32.05 O +ATOM 7094 CB LYS E 69 -1.559 57.941 26.893 1.00 23.70 C +ATOM 7095 CG LYS E 69 -0.634 57.485 28.024 1.00 42.05 C +ATOM 7096 CD LYS E 69 -0.028 56.106 27.775 1.00 61.46 C +ATOM 7097 CE LYS E 69 0.376 55.378 29.068 1.00 58.14 C +ATOM 7098 NZ LYS E 69 -0.804 54.821 29.794 1.00 56.69 N +ATOM 7099 N ASP E 70 0.894 57.101 24.746 1.00 30.08 N +ATOM 7100 CA ASP E 70 1.486 56.023 23.944 1.00 41.16 C +ATOM 7101 C ASP E 70 1.470 56.181 22.413 1.00 43.62 C +ATOM 7102 O ASP E 70 1.913 55.278 21.687 1.00 52.18 O +ATOM 7103 CB ASP E 70 0.857 54.660 24.306 1.00 47.75 C +ATOM 7104 CG ASP E 70 1.407 54.067 25.602 1.00 56.40 C +ATOM 7105 OD1 ASP E 70 2.455 54.539 26.108 1.00 57.92 O +ATOM 7106 OD2 ASP E 70 0.775 53.112 26.112 1.00 62.97 O +ATOM 7107 N ILE E 71 0.959 57.295 21.908 1.00 38.56 N +ATOM 7108 CA ILE E 71 0.925 57.490 20.460 1.00 32.62 C +ATOM 7109 C ILE E 71 1.730 58.726 20.029 1.00 30.67 C +ATOM 7110 O ILE E 71 2.758 58.604 19.341 1.00 27.40 O +ATOM 7111 CB ILE E 71 -0.538 57.584 19.934 1.00 34.57 C +ATOM 7112 CG1 ILE E 71 -1.288 56.283 20.238 1.00 40.01 C +ATOM 7113 CG2 ILE E 71 -0.559 57.867 18.438 1.00 19.30 C +ATOM 7114 CD1 ILE E 71 -2.736 56.258 19.729 1.00 50.09 C +ATOM 7115 N GLY E 72 1.264 59.907 20.446 1.00 25.79 N +ATOM 7116 CA GLY E 72 1.931 61.152 20.100 1.00 15.21 C +ATOM 7117 C GLY E 72 0.949 62.307 20.040 1.00 14.94 C +ATOM 7118 O GLY E 72 -0.056 62.329 20.751 1.00 17.32 O +ATOM 7119 N TYR E 73 1.245 63.281 19.193 1.00 11.24 N +ATOM 7120 CA TYR E 73 0.393 64.433 19.048 1.00 8.50 C +ATOM 7121 C TYR E 73 -0.769 64.125 18.151 1.00 8.50 C +ATOM 7122 O TYR E 73 -0.614 63.567 17.080 1.00 8.50 O +ATOM 7123 CB TYR E 73 1.189 65.603 18.512 1.00 8.50 C +ATOM 7124 CG TYR E 73 2.205 66.084 19.495 1.00 8.50 C +ATOM 7125 CD1 TYR E 73 1.821 66.839 20.598 1.00 8.50 C +ATOM 7126 CD2 TYR E 73 3.538 65.756 19.346 1.00 8.50 C +ATOM 7127 CE1 TYR E 73 2.746 67.258 21.534 1.00 12.01 C +ATOM 7128 CE2 TYR E 73 4.472 66.158 20.266 1.00 10.15 C +ATOM 7129 CZ TYR E 73 4.082 66.911 21.364 1.00 18.02 C +ATOM 7130 OH TYR E 73 5.038 67.314 22.275 1.00 26.15 O +ATOM 7131 N SER E 74 -1.940 64.507 18.619 1.00 9.33 N +ATOM 7132 CA SER E 74 -3.180 64.301 17.909 1.00 12.89 C +ATOM 7133 C SER E 74 -3.728 65.662 17.505 1.00 12.13 C +ATOM 7134 O SER E 74 -4.253 66.411 18.336 1.00 12.50 O +ATOM 7135 CB SER E 74 -4.185 63.586 18.822 1.00 19.72 C +ATOM 7136 OG SER E 74 -5.484 63.531 18.247 1.00 28.73 O +ATOM 7137 N PHE E 75 -3.573 65.994 16.233 1.00 10.71 N +ATOM 7138 CA PHE E 75 -4.062 67.260 15.725 1.00 10.59 C +ATOM 7139 C PHE E 75 -5.380 67.041 14.996 1.00 9.83 C +ATOM 7140 O PHE E 75 -5.421 66.350 13.991 1.00 13.27 O +ATOM 7141 CB PHE E 75 -3.032 67.885 14.784 1.00 9.17 C +ATOM 7142 CG PHE E 75 -3.472 69.195 14.190 1.00 8.50 C +ATOM 7143 CD1 PHE E 75 -3.628 70.312 14.986 1.00 8.50 C +ATOM 7144 CD2 PHE E 75 -3.754 69.304 12.834 1.00 15.33 C +ATOM 7145 CE1 PHE E 75 -4.059 71.508 14.448 1.00 10.16 C +ATOM 7146 CE2 PHE E 75 -4.191 70.509 12.282 1.00 8.50 C +ATOM 7147 CZ PHE E 75 -4.343 71.601 13.083 1.00 9.09 C +ATOM 7148 N THR E 76 -6.451 67.639 15.491 1.00 11.77 N +ATOM 7149 CA THR E 76 -7.764 67.483 14.873 1.00 13.17 C +ATOM 7150 C THR E 76 -8.431 68.822 14.527 1.00 14.26 C +ATOM 7151 O THR E 76 -8.480 69.754 15.342 1.00 13.02 O +ATOM 7152 CB THR E 76 -8.709 66.570 15.752 1.00 16.72 C +ATOM 7153 OG1 THR E 76 -10.057 67.073 15.757 1.00 8.50 O +ATOM 7154 CG2 THR E 76 -8.184 66.445 17.187 1.00 20.03 C +ATOM 7155 N VAL E 77 -8.879 68.942 13.282 1.00 14.21 N +ATOM 7156 CA VAL E 77 -9.555 70.152 12.827 1.00 18.52 C +ATOM 7157 C VAL E 77 -10.848 69.745 12.141 1.00 22.31 C +ATOM 7158 O VAL E 77 -10.833 68.895 11.257 1.00 25.23 O +ATOM 7159 CB VAL E 77 -8.655 71.035 11.883 1.00 11.98 C +ATOM 7160 CG1 VAL E 77 -7.755 70.199 11.058 1.00 13.47 C +ATOM 7161 CG2 VAL E 77 -9.511 71.898 10.966 1.00 12.50 C +ATOM 7162 N GLY E 78 -11.964 70.292 12.620 1.00 20.33 N +ATOM 7163 CA GLY E 78 -13.258 69.993 12.045 1.00 17.55 C +ATOM 7164 C GLY E 78 -13.724 68.600 12.395 1.00 20.43 C +ATOM 7165 O GLY E 78 -14.352 67.927 11.574 1.00 29.03 O +ATOM 7166 N GLY E 79 -13.416 68.165 13.610 1.00 19.19 N +ATOM 7167 CA GLY E 79 -13.820 66.838 14.043 1.00 20.48 C +ATOM 7168 C GLY E 79 -12.998 65.677 13.483 1.00 21.05 C +ATOM 7169 O GLY E 79 -13.123 64.544 13.971 1.00 21.07 O +ATOM 7170 N SER E 80 -12.182 65.938 12.461 1.00 19.13 N +ATOM 7171 CA SER E 80 -11.337 64.908 11.861 1.00 19.09 C +ATOM 7172 C SER E 80 -9.916 64.964 12.426 1.00 21.75 C +ATOM 7173 O SER E 80 -9.247 66.000 12.403 1.00 30.08 O +ATOM 7174 CB SER E 80 -11.332 65.032 10.341 1.00 21.38 C +ATOM 7175 OG SER E 80 -12.620 64.750 9.800 1.00 34.39 O +ATOM 7176 N GLU E 81 -9.473 63.829 12.940 1.00 17.20 N +ATOM 7177 CA GLU E 81 -8.177 63.675 13.575 1.00 14.48 C +ATOM 7178 C GLU E 81 -7.052 63.217 12.642 1.00 13.25 C +ATOM 7179 O GLU E 81 -7.303 62.658 11.588 1.00 17.91 O +ATOM 7180 CB GLU E 81 -8.356 62.683 14.727 1.00 14.32 C +ATOM 7181 CG GLU E 81 -7.120 62.370 15.534 1.00 32.52 C +ATOM 7182 CD GLU E 81 -7.315 61.169 16.427 1.00 39.10 C +ATOM 7183 OE1 GLU E 81 -7.597 60.080 15.882 1.00 46.00 O +ATOM 7184 OE2 GLU E 81 -7.187 61.315 17.667 1.00 50.17 O +ATOM 7185 N ILE E 82 -5.814 63.471 13.056 1.00 13.81 N +ATOM 7186 CA ILE E 82 -4.611 63.100 12.323 1.00 9.72 C +ATOM 7187 C ILE E 82 -3.522 62.922 13.381 1.00 9.67 C +ATOM 7188 O ILE E 82 -3.546 63.586 14.421 1.00 8.50 O +ATOM 7189 CB ILE E 82 -4.231 64.164 11.287 1.00 8.50 C +ATOM 7190 CG1 ILE E 82 -3.459 63.529 10.157 1.00 8.50 C +ATOM 7191 CG2 ILE E 82 -3.395 65.268 11.903 1.00 10.68 C +ATOM 7192 CD1 ILE E 82 -3.355 64.432 8.960 1.00 22.54 C +ATOM 7193 N LEU E 83 -2.571 62.032 13.132 1.00 8.50 N +ATOM 7194 CA LEU E 83 -1.576 61.755 14.142 1.00 8.77 C +ATOM 7195 C LEU E 83 -0.154 62.020 13.792 1.00 13.53 C +ATOM 7196 O LEU E 83 0.275 61.780 12.668 1.00 16.58 O +ATOM 7197 CB LEU E 83 -1.703 60.307 14.617 1.00 10.76 C +ATOM 7198 CG LEU E 83 -2.490 59.972 15.884 1.00 9.14 C +ATOM 7199 CD1 LEU E 83 -3.806 60.701 15.929 1.00 16.50 C +ATOM 7200 CD2 LEU E 83 -2.724 58.489 15.946 1.00 18.29 C +ATOM 7201 N PHE E 84 0.576 62.497 14.795 1.00 16.08 N +ATOM 7202 CA PHE E 84 1.998 62.778 14.676 1.00 18.07 C +ATOM 7203 C PHE E 84 2.633 61.959 15.766 1.00 16.21 C +ATOM 7204 O PHE E 84 2.639 62.337 16.929 1.00 15.73 O +ATOM 7205 CB PHE E 84 2.295 64.265 14.806 1.00 8.50 C +ATOM 7206 CG PHE E 84 1.877 65.031 13.616 1.00 8.50 C +ATOM 7207 CD1 PHE E 84 2.506 64.820 12.403 1.00 8.50 C +ATOM 7208 CD2 PHE E 84 0.805 65.913 13.684 1.00 8.92 C +ATOM 7209 CE1 PHE E 84 2.076 65.472 11.266 1.00 8.50 C +ATOM 7210 CE2 PHE E 84 0.362 66.573 12.560 1.00 8.50 C +ATOM 7211 CZ PHE E 84 1.001 66.353 11.339 1.00 8.68 C +ATOM 7212 N GLU E 85 3.058 60.771 15.370 1.00 15.16 N +ATOM 7213 CA GLU E 85 3.651 59.829 16.271 1.00 23.14 C +ATOM 7214 C GLU E 85 4.951 60.288 16.903 1.00 24.71 C +ATOM 7215 O GLU E 85 5.824 60.825 16.222 1.00 25.93 O +ATOM 7216 CB GLU E 85 3.835 58.511 15.534 1.00 43.59 C +ATOM 7217 CG GLU E 85 2.576 58.052 14.811 1.00 56.87 C +ATOM 7218 CD GLU E 85 2.488 56.540 14.713 1.00 72.85 C +ATOM 7219 OE1 GLU E 85 3.084 55.975 13.770 1.00 84.85 O +ATOM 7220 OE2 GLU E 85 1.830 55.919 15.585 1.00 74.52 O +ATOM 7221 N VAL E 86 5.048 60.091 18.219 1.00 28.77 N +ATOM 7222 CA VAL E 86 6.231 60.444 19.003 1.00 35.44 C +ATOM 7223 C VAL E 86 6.483 59.253 19.920 1.00 48.11 C +ATOM 7224 O VAL E 86 5.823 59.110 20.958 1.00 54.94 O +ATOM 7225 CB VAL E 86 5.997 61.715 19.848 1.00 33.35 C +ATOM 7226 CG1 VAL E 86 7.148 61.939 20.803 1.00 36.59 C +ATOM 7227 CG2 VAL E 86 5.853 62.931 18.942 1.00 40.72 C +ATOM 7228 N PRO E 87 7.432 58.370 19.536 1.00 54.66 N +ATOM 7229 CA PRO E 87 7.818 57.157 20.272 1.00 61.81 C +ATOM 7230 C PRO E 87 8.456 57.376 21.651 1.00 71.30 C +ATOM 7231 O PRO E 87 7.904 56.956 22.679 1.00 76.64 O +ATOM 7232 CB PRO E 87 8.782 56.473 19.303 1.00 53.11 C +ATOM 7233 CG PRO E 87 9.436 57.620 18.631 1.00 51.85 C +ATOM 7234 CD PRO E 87 8.271 58.528 18.335 1.00 53.17 C +ATOM 7235 N GLU E 88 9.628 58.006 21.660 1.00 75.21 N +ATOM 7236 CA GLU E 88 10.359 58.274 22.890 1.00 76.26 C +ATOM 7237 C GLU E 88 9.907 59.618 23.439 1.00 70.35 C +ATOM 7238 O GLU E 88 10.198 60.669 22.856 1.00 67.64 O +ATOM 7239 CB GLU E 88 11.866 58.295 22.598 1.00 87.33 C +ATOM 7240 CG GLU E 88 12.769 58.253 23.833 1.00 99.99 C +ATOM 7241 CD GLU E 88 14.242 58.518 23.511 1.00104.56 C +ATOM 7242 OE1 GLU E 88 14.741 58.011 22.481 1.00105.34 O +ATOM 7243 OE2 GLU E 88 14.903 59.240 24.292 1.00106.17 O +ATOM 7244 N VAL E 89 9.145 59.579 24.524 1.00 67.13 N +ATOM 7245 CA VAL E 89 8.665 60.812 25.138 1.00 70.13 C +ATOM 7246 C VAL E 89 9.684 61.307 26.167 1.00 66.64 C +ATOM 7247 O VAL E 89 10.232 60.518 26.943 1.00 65.65 O +ATOM 7248 CB VAL E 89 7.247 60.643 25.799 1.00 75.68 C +ATOM 7249 CG1 VAL E 89 7.294 59.736 27.037 1.00 71.73 C +ATOM 7250 CG2 VAL E 89 6.681 62.011 26.163 1.00 78.35 C +ATOM 7251 N THR E 90 9.965 62.604 26.141 1.00 64.09 N +ATOM 7252 CA THR E 90 10.918 63.193 27.068 1.00 62.01 C +ATOM 7253 C THR E 90 10.219 64.270 27.892 1.00 56.89 C +ATOM 7254 O THR E 90 9.276 64.924 27.421 1.00 61.04 O +ATOM 7255 CB THR E 90 12.154 63.792 26.325 1.00 67.82 C +ATOM 7256 OG1 THR E 90 13.175 64.130 27.276 1.00 67.22 O +ATOM 7257 CG2 THR E 90 11.763 65.047 25.510 1.00 66.10 C +ATOM 7258 N VAL E 91 10.674 64.434 29.129 1.00 47.27 N +ATOM 7259 CA VAL E 91 10.109 65.422 30.039 1.00 41.08 C +ATOM 7260 C VAL E 91 10.970 66.692 30.044 1.00 40.28 C +ATOM 7261 O VAL E 91 12.128 66.681 30.500 1.00 42.36 O +ATOM 7262 CB VAL E 91 9.967 64.840 31.475 1.00 42.00 C +ATOM 7263 CG1 VAL E 91 11.301 64.299 31.975 1.00 39.93 C +ATOM 7264 CG2 VAL E 91 9.411 65.889 32.428 1.00 48.81 C +ATOM 7265 N ALA E 92 10.413 67.764 29.477 1.00 31.55 N +ATOM 7266 CA ALA E 92 11.077 69.070 29.386 1.00 14.08 C +ATOM 7267 C ALA E 92 10.061 69.980 28.735 1.00 12.16 C +ATOM 7268 O ALA E 92 9.081 69.499 28.146 1.00 21.50 O +ATOM 7269 CB ALA E 92 12.318 68.974 28.510 1.00 23.19 C +ATOM 7270 N PRO E 93 10.220 71.301 28.886 1.00 8.50 N +ATOM 7271 CA PRO E 93 9.218 72.141 28.233 1.00 8.50 C +ATOM 7272 C PRO E 93 9.317 71.881 26.739 1.00 8.50 C +ATOM 7273 O PRO E 93 10.384 71.551 26.221 1.00 21.15 O +ATOM 7274 CB PRO E 93 9.679 73.545 28.582 1.00 8.50 C +ATOM 7275 CG PRO E 93 10.327 73.364 29.900 1.00 12.95 C +ATOM 7276 CD PRO E 93 11.139 72.114 29.694 1.00 13.29 C +ATOM 7277 N VAL E 94 8.198 71.974 26.058 1.00 8.50 N +ATOM 7278 CA VAL E 94 8.175 71.741 24.632 1.00 8.50 C +ATOM 7279 C VAL E 94 7.393 72.871 23.948 1.00 11.06 C +ATOM 7280 O VAL E 94 6.475 73.457 24.532 1.00 9.26 O +ATOM 7281 CB VAL E 94 7.617 70.327 24.324 1.00 8.50 C +ATOM 7282 CG1 VAL E 94 6.495 69.996 25.269 1.00 24.94 C +ATOM 7283 CG2 VAL E 94 7.152 70.205 22.891 1.00 8.50 C +ATOM 7284 N HIS E 95 7.841 73.253 22.758 1.00 8.64 N +ATOM 7285 CA HIS E 95 7.218 74.330 22.013 1.00 8.50 C +ATOM 7286 C HIS E 95 6.702 73.758 20.714 1.00 8.94 C +ATOM 7287 O HIS E 95 7.453 73.119 19.984 1.00 15.27 O +ATOM 7288 CB HIS E 95 8.270 75.425 21.731 1.00 11.78 C +ATOM 7289 CG HIS E 95 7.832 76.474 20.745 1.00 11.34 C +ATOM 7290 ND1 HIS E 95 7.160 77.618 21.120 1.00 8.50 N +ATOM 7291 CD2 HIS E 95 7.963 76.544 19.397 1.00 9.64 C +ATOM 7292 CE1 HIS E 95 6.890 78.343 20.050 1.00 8.50 C +ATOM 7293 NE2 HIS E 95 7.367 77.711 18.992 1.00 8.50 N +ATOM 7294 N ILE E 96 5.433 73.985 20.413 1.00 8.50 N +ATOM 7295 CA ILE E 96 4.860 73.486 19.175 1.00 8.50 C +ATOM 7296 C ILE E 96 4.166 74.575 18.377 1.00 8.50 C +ATOM 7297 O ILE E 96 3.674 75.540 18.934 1.00 11.00 O +ATOM 7298 CB ILE E 96 3.832 72.350 19.424 1.00 9.80 C +ATOM 7299 CG1 ILE E 96 2.707 72.826 20.329 1.00 10.84 C +ATOM 7300 CG2 ILE E 96 4.487 71.136 20.049 1.00 8.50 C +ATOM 7301 CD1 ILE E 96 1.565 71.864 20.376 1.00 13.76 C +ATOM 7302 N CYS E 97 4.217 74.455 17.062 1.00 8.50 N +ATOM 7303 CA CYS E 97 3.562 75.386 16.145 1.00 11.11 C +ATOM 7304 C CYS E 97 2.899 74.437 15.177 1.00 9.61 C +ATOM 7305 O CYS E 97 3.534 73.504 14.718 1.00 9.51 O +ATOM 7306 CB CYS E 97 4.561 76.241 15.336 1.00 12.62 C +ATOM 7307 SG CYS E 97 5.185 77.799 16.047 1.00 8.50 S +ATOM 7308 N THR E 98 1.635 74.673 14.873 1.00 10.20 N +ATOM 7309 CA THR E 98 0.906 73.829 13.953 1.00 9.00 C +ATOM 7310 C THR E 98 0.075 74.717 13.046 1.00 8.50 C +ATOM 7311 O THR E 98 -0.397 75.754 13.471 1.00 11.28 O +ATOM 7312 CB THR E 98 0.035 72.814 14.718 1.00 10.92 C +ATOM 7313 OG1 THR E 98 -0.632 71.956 13.790 1.00 28.56 O +ATOM 7314 CG2 THR E 98 -0.993 73.501 15.578 1.00 11.69 C +ATOM 7315 N SER E 99 -0.056 74.336 11.785 1.00 8.55 N +ATOM 7316 CA SER E 99 -0.801 75.120 10.804 1.00 11.95 C +ATOM 7317 C SER E 99 -1.627 74.291 9.826 1.00 11.94 C +ATOM 7318 O SER E 99 -1.279 73.164 9.526 1.00 20.92 O +ATOM 7319 CB SER E 99 0.148 76.057 10.032 1.00 14.45 C +ATOM 7320 OG SER E 99 1.250 75.396 9.426 1.00 8.50 O +ATOM 7321 N TRP E 100 -2.716 74.867 9.331 1.00 14.72 N +ATOM 7322 CA TRP E 100 -3.627 74.203 8.402 1.00 11.77 C +ATOM 7323 C TRP E 100 -4.071 75.176 7.319 1.00 11.26 C +ATOM 7324 O TRP E 100 -4.243 76.359 7.582 1.00 18.22 O +ATOM 7325 CB TRP E 100 -4.846 73.665 9.165 1.00 8.50 C +ATOM 7326 CG TRP E 100 -5.982 73.241 8.296 1.00 10.15 C +ATOM 7327 CD1 TRP E 100 -6.122 72.051 7.633 1.00 10.99 C +ATOM 7328 CD2 TRP E 100 -7.154 74.001 8.003 1.00 10.85 C +ATOM 7329 NE1 TRP E 100 -7.314 72.034 6.951 1.00 11.81 N +ATOM 7330 CE2 TRP E 100 -7.967 73.219 7.162 1.00 8.56 C +ATOM 7331 CE3 TRP E 100 -7.599 75.268 8.373 1.00 10.72 C +ATOM 7332 CZ2 TRP E 100 -9.198 73.667 6.686 1.00 11.54 C +ATOM 7333 CZ3 TRP E 100 -8.826 75.709 7.898 1.00 14.97 C +ATOM 7334 CH2 TRP E 100 -9.608 74.913 7.066 1.00 9.42 C +ATOM 7335 N GLU E 101 -4.280 74.671 6.111 1.00 11.41 N +ATOM 7336 CA GLU E 101 -4.691 75.488 4.971 1.00 14.82 C +ATOM 7337 C GLU E 101 -5.847 74.821 4.257 1.00 17.35 C +ATOM 7338 O GLU E 101 -5.682 73.737 3.720 1.00 21.74 O +ATOM 7339 CB GLU E 101 -3.519 75.634 4.000 1.00 14.81 C +ATOM 7340 CG GLU E 101 -3.811 76.399 2.720 1.00 18.53 C +ATOM 7341 CD GLU E 101 -2.601 76.449 1.794 1.00 22.90 C +ATOM 7342 OE1 GLU E 101 -2.254 75.411 1.188 1.00 18.99 O +ATOM 7343 OE2 GLU E 101 -1.992 77.526 1.664 1.00 26.75 O +ATOM 7344 N SER E 102 -7.005 75.473 4.218 1.00 19.51 N +ATOM 7345 CA SER E 102 -8.179 74.901 3.559 1.00 17.77 C +ATOM 7346 C SER E 102 -7.898 74.554 2.106 1.00 19.29 C +ATOM 7347 O SER E 102 -8.169 73.440 1.667 1.00 25.28 O +ATOM 7348 CB SER E 102 -9.377 75.860 3.634 1.00 18.98 C +ATOM 7349 OG SER E 102 -10.448 75.451 2.791 1.00 8.50 O +ATOM 7350 N ALA E 103 -7.285 75.483 1.384 1.00 16.76 N +ATOM 7351 CA ALA E 103 -6.975 75.292 -0.033 1.00 14.94 C +ATOM 7352 C ALA E 103 -6.293 73.989 -0.460 1.00 14.70 C +ATOM 7353 O ALA E 103 -6.468 73.564 -1.600 1.00 26.79 O +ATOM 7354 CB ALA E 103 -6.172 76.481 -0.552 1.00 20.69 C +ATOM 7355 N SER E 104 -5.517 73.361 0.419 1.00 10.32 N +ATOM 7356 CA SER E 104 -4.818 72.128 0.052 1.00 12.79 C +ATOM 7357 C SER E 104 -4.965 71.014 1.086 1.00 13.04 C +ATOM 7358 O SER E 104 -4.723 69.838 0.799 1.00 10.15 O +ATOM 7359 CB SER E 104 -3.339 72.428 -0.135 1.00 9.29 C +ATOM 7360 OG SER E 104 -2.789 72.773 1.117 1.00 14.08 O +ATOM 7361 N GLY E 105 -5.335 71.407 2.295 1.00 14.67 N +ATOM 7362 CA GLY E 105 -5.497 70.459 3.373 1.00 13.42 C +ATOM 7363 C GLY E 105 -4.158 70.170 4.027 1.00 15.54 C +ATOM 7364 O GLY E 105 -4.085 69.369 4.961 1.00 23.20 O +ATOM 7365 N ILE E 106 -3.096 70.822 3.567 1.00 8.50 N +ATOM 7366 CA ILE E 106 -1.799 70.574 4.155 1.00 8.50 C +ATOM 7367 C ILE E 106 -1.675 71.119 5.557 1.00 8.50 C +ATOM 7368 O ILE E 106 -1.862 72.308 5.780 1.00 13.05 O +ATOM 7369 CB ILE E 106 -0.665 71.143 3.296 1.00 8.50 C +ATOM 7370 CG1 ILE E 106 -0.621 70.417 1.960 1.00 12.92 C +ATOM 7371 CG2 ILE E 106 0.670 70.959 3.981 1.00 10.83 C +ATOM 7372 CD1 ILE E 106 0.520 70.854 1.075 1.00 8.50 C +ATOM 7373 N VAL E 107 -1.355 70.237 6.496 1.00 8.50 N +ATOM 7374 CA VAL E 107 -1.143 70.604 7.885 1.00 8.50 C +ATOM 7375 C VAL E 107 0.311 70.295 8.255 1.00 8.50 C +ATOM 7376 O VAL E 107 0.829 69.267 7.878 1.00 9.00 O +ATOM 7377 CB VAL E 107 -2.138 69.897 8.818 1.00 8.50 C +ATOM 7378 CG1 VAL E 107 -2.362 68.495 8.387 1.00 15.21 C +ATOM 7379 CG2 VAL E 107 -1.634 69.925 10.233 1.00 8.50 C +ATOM 7380 N GLU E 108 0.993 71.249 8.878 1.00 9.46 N +ATOM 7381 CA GLU E 108 2.390 71.100 9.293 1.00 9.58 C +ATOM 7382 C GLU E 108 2.377 71.045 10.814 1.00 8.81 C +ATOM 7383 O GLU E 108 1.517 71.644 11.448 1.00 8.50 O +ATOM 7384 CB GLU E 108 3.228 72.332 8.901 1.00 15.65 C +ATOM 7385 CG GLU E 108 3.392 72.669 7.422 1.00 10.72 C +ATOM 7386 CD GLU E 108 4.038 74.054 7.196 1.00 25.38 C +ATOM 7387 OE1 GLU E 108 4.275 74.807 8.173 1.00 26.66 O +ATOM 7388 OE2 GLU E 108 4.297 74.408 6.028 1.00 34.54 O +ATOM 7389 N PHE E 109 3.332 70.339 11.400 1.00 10.55 N +ATOM 7390 CA PHE E 109 3.424 70.266 12.855 1.00 9.01 C +ATOM 7391 C PHE E 109 4.916 70.429 13.129 1.00 10.62 C +ATOM 7392 O PHE E 109 5.726 69.677 12.600 1.00 10.64 O +ATOM 7393 CB PHE E 109 2.927 68.918 13.374 1.00 8.50 C +ATOM 7394 CG PHE E 109 2.439 68.943 14.787 1.00 8.50 C +ATOM 7395 CD1 PHE E 109 1.125 69.273 15.067 1.00 8.50 C +ATOM 7396 CD2 PHE E 109 3.288 68.630 15.837 1.00 8.50 C +ATOM 7397 CE1 PHE E 109 0.652 69.300 16.377 1.00 8.50 C +ATOM 7398 CE2 PHE E 109 2.834 68.654 17.140 1.00 8.50 C +ATOM 7399 CZ PHE E 109 1.508 68.994 17.410 1.00 8.50 C +ATOM 7400 N TRP E 110 5.278 71.487 13.852 1.00 12.69 N +ATOM 7401 CA TRP E 110 6.666 71.770 14.190 1.00 8.50 C +ATOM 7402 C TRP E 110 6.855 71.587 15.669 1.00 8.50 C +ATOM 7403 O TRP E 110 6.204 72.255 16.459 1.00 14.85 O +ATOM 7404 CB TRP E 110 7.005 73.217 13.865 1.00 8.50 C +ATOM 7405 CG TRP E 110 6.909 73.565 12.437 1.00 8.50 C +ATOM 7406 CD1 TRP E 110 5.774 73.674 11.698 1.00 8.50 C +ATOM 7407 CD2 TRP E 110 7.995 73.856 11.556 1.00 8.50 C +ATOM 7408 NE1 TRP E 110 6.085 74.013 10.405 1.00 8.50 N +ATOM 7409 CE2 TRP E 110 7.443 74.126 10.292 1.00 8.50 C +ATOM 7410 CE3 TRP E 110 9.374 73.918 11.714 1.00 8.50 C +ATOM 7411 CZ2 TRP E 110 8.221 74.449 9.196 1.00 8.50 C +ATOM 7412 CZ3 TRP E 110 10.155 74.246 10.615 1.00 8.50 C +ATOM 7413 CH2 TRP E 110 9.581 74.504 9.377 1.00 8.50 C +ATOM 7414 N VAL E 111 7.759 70.710 16.057 1.00 8.50 N +ATOM 7415 CA VAL E 111 8.018 70.479 17.468 1.00 8.50 C +ATOM 7416 C VAL E 111 9.420 70.949 17.740 1.00 8.88 C +ATOM 7417 O VAL E 111 10.361 70.497 17.108 1.00 13.03 O +ATOM 7418 CB VAL E 111 7.894 68.992 17.852 1.00 8.50 C +ATOM 7419 CG1 VAL E 111 8.170 68.809 19.315 1.00 9.36 C +ATOM 7420 CG2 VAL E 111 6.494 68.480 17.519 1.00 13.57 C +ATOM 7421 N ASP E 112 9.544 71.899 18.654 1.00 10.98 N +ATOM 7422 CA ASP E 112 10.832 72.485 19.033 1.00 9.53 C +ATOM 7423 C ASP E 112 11.647 73.055 17.874 1.00 9.23 C +ATOM 7424 O ASP E 112 12.865 72.904 17.818 1.00 8.50 O +ATOM 7425 CB ASP E 112 11.676 71.509 19.849 1.00 8.50 C +ATOM 7426 CG ASP E 112 11.271 71.462 21.318 1.00 14.44 C +ATOM 7427 OD1 ASP E 112 10.819 72.505 21.862 1.00 9.38 O +ATOM 7428 OD2 ASP E 112 11.432 70.378 21.935 1.00 13.30 O +ATOM 7429 N GLY E 113 10.959 73.733 16.961 1.00 12.34 N +ATOM 7430 CA GLY E 113 11.637 74.340 15.829 1.00 13.06 C +ATOM 7431 C GLY E 113 11.949 73.431 14.648 1.00 16.21 C +ATOM 7432 O GLY E 113 12.419 73.902 13.599 1.00 17.04 O +ATOM 7433 N LYS E 114 11.730 72.130 14.822 1.00 14.68 N +ATOM 7434 CA LYS E 114 11.966 71.187 13.751 1.00 8.50 C +ATOM 7435 C LYS E 114 10.639 70.613 13.247 1.00 8.50 C +ATOM 7436 O LYS E 114 9.770 70.214 14.019 1.00 8.68 O +ATOM 7437 CB LYS E 114 13.029 70.186 14.152 1.00 15.16 C +ATOM 7438 CG LYS E 114 14.391 70.886 14.234 1.00 23.32 C +ATOM 7439 CD LYS E 114 15.535 70.005 14.737 1.00 29.17 C +ATOM 7440 CE LYS E 114 16.081 69.069 13.665 1.00 19.70 C +ATOM 7441 NZ LYS E 114 17.410 68.530 14.100 1.00 37.09 N +ATOM 7442 N PRO E 115 10.443 70.644 11.925 1.00 8.50 N +ATOM 7443 CA PRO E 115 9.249 70.177 11.238 1.00 8.50 C +ATOM 7444 C PRO E 115 9.062 68.685 11.071 1.00 9.88 C +ATOM 7445 O PRO E 115 10.007 67.953 10.787 1.00 8.71 O +ATOM 7446 CB PRO E 115 9.406 70.810 9.875 1.00 8.50 C +ATOM 7447 CG PRO E 115 10.854 70.616 9.618 1.00 8.50 C +ATOM 7448 CD PRO E 115 11.474 71.024 10.931 1.00 11.81 C +ATOM 7449 N ARG E 116 7.820 68.259 11.223 1.00 8.50 N +ATOM 7450 CA ARG E 116 7.440 66.881 11.029 1.00 8.50 C +ATOM 7451 C ARG E 116 6.986 66.937 9.584 1.00 11.32 C +ATOM 7452 O ARG E 116 6.802 68.028 9.049 1.00 16.35 O +ATOM 7453 CB ARG E 116 6.263 66.530 11.937 1.00 13.60 C +ATOM 7454 CG ARG E 116 6.516 66.764 13.414 1.00 16.97 C +ATOM 7455 CD ARG E 116 7.422 65.694 14.009 1.00 35.96 C +ATOM 7456 NE ARG E 116 6.709 64.436 14.228 1.00 33.06 N +ATOM 7457 CZ ARG E 116 6.764 63.398 13.406 1.00 36.99 C +ATOM 7458 NH1 ARG E 116 7.503 63.455 12.302 1.00 33.27 N +ATOM 7459 NH2 ARG E 116 6.072 62.306 13.690 1.00 42.73 N +ATOM 7460 N VAL E 117 6.764 65.791 8.951 1.00 15.27 N +ATOM 7461 CA VAL E 117 6.333 65.786 7.549 1.00 11.67 C +ATOM 7462 C VAL E 117 4.964 66.440 7.376 1.00 14.77 C +ATOM 7463 O VAL E 117 4.224 66.610 8.354 1.00 16.63 O +ATOM 7464 CB VAL E 117 6.268 64.384 6.973 1.00 8.97 C +ATOM 7465 CG1 VAL E 117 6.395 64.458 5.468 1.00 9.46 C +ATOM 7466 CG2 VAL E 117 7.341 63.507 7.587 1.00 8.50 C +ATOM 7467 N ARG E 118 4.656 66.842 6.143 1.00 11.83 N +ATOM 7468 CA ARG E 118 3.386 67.488 5.853 1.00 8.74 C +ATOM 7469 C ARG E 118 2.324 66.453 5.584 1.00 8.73 C +ATOM 7470 O ARG E 118 2.564 65.496 4.867 1.00 16.58 O +ATOM 7471 CB ARG E 118 3.498 68.403 4.644 1.00 9.35 C +ATOM 7472 CG ARG E 118 4.534 69.487 4.757 1.00 11.79 C +ATOM 7473 CD ARG E 118 4.321 70.509 3.668 1.00 15.45 C +ATOM 7474 NE ARG E 118 5.576 71.068 3.182 1.00 11.51 N +ATOM 7475 CZ ARG E 118 5.984 72.304 3.408 1.00 8.50 C +ATOM 7476 NH1 ARG E 118 5.251 73.131 4.113 1.00 8.50 N +ATOM 7477 NH2 ARG E 118 7.116 72.712 2.904 1.00 8.50 N +ATOM 7478 N LYS E 119 1.138 66.663 6.135 1.00 12.15 N +ATOM 7479 CA LYS E 119 0.025 65.737 5.967 1.00 12.39 C +ATOM 7480 C LYS E 119 -1.207 66.463 5.430 1.00 11.89 C +ATOM 7481 O LYS E 119 -1.244 67.687 5.412 1.00 14.29 O +ATOM 7482 CB LYS E 119 -0.266 65.038 7.296 1.00 8.50 C +ATOM 7483 CG LYS E 119 0.890 64.170 7.732 1.00 8.50 C +ATOM 7484 CD LYS E 119 0.557 63.326 8.931 1.00 10.28 C +ATOM 7485 CE LYS E 119 1.637 62.274 9.161 1.00 26.16 C +ATOM 7486 NZ LYS E 119 1.412 61.429 10.370 1.00 33.80 N +ATOM 7487 N SER E 120 -2.183 65.714 4.933 1.00 13.78 N +ATOM 7488 CA SER E 120 -3.392 66.313 4.389 1.00 9.82 C +ATOM 7489 C SER E 120 -4.538 66.095 5.369 1.00 9.12 C +ATOM 7490 O SER E 120 -4.656 65.027 5.956 1.00 14.44 O +ATOM 7491 CB SER E 120 -3.707 65.687 3.028 1.00 8.50 C +ATOM 7492 OG SER E 120 -4.607 66.467 2.269 1.00 9.18 O +ATOM 7493 N LEU E 121 -5.385 67.100 5.544 1.00 9.20 N +ATOM 7494 CA LEU E 121 -6.517 67.004 6.457 1.00 8.69 C +ATOM 7495 C LEU E 121 -7.540 68.121 6.239 1.00 16.01 C +ATOM 7496 O LEU E 121 -7.191 69.298 6.184 1.00 16.93 O +ATOM 7497 CB LEU E 121 -6.017 67.015 7.892 1.00 8.50 C +ATOM 7498 CG LEU E 121 -7.015 67.231 9.018 1.00 8.74 C +ATOM 7499 CD1 LEU E 121 -8.062 66.159 8.979 1.00 16.62 C +ATOM 7500 CD2 LEU E 121 -6.293 67.207 10.351 1.00 11.28 C +ATOM 7501 N LYS E 122 -8.798 67.720 6.066 1.00 20.02 N +ATOM 7502 CA LYS E 122 -9.934 68.618 5.866 1.00 11.22 C +ATOM 7503 C LYS E 122 -9.802 69.663 4.779 1.00 16.45 C +ATOM 7504 O LYS E 122 -10.103 70.837 5.009 1.00 15.81 O +ATOM 7505 CB LYS E 122 -10.311 69.300 7.171 1.00 8.50 C +ATOM 7506 CG LYS E 122 -11.169 68.462 8.056 1.00 10.64 C +ATOM 7507 CD LYS E 122 -12.568 68.318 7.488 1.00 18.79 C +ATOM 7508 CE LYS E 122 -13.461 67.491 8.401 1.00 27.53 C +ATOM 7509 NZ LYS E 122 -14.852 67.379 7.910 1.00 37.85 N +ATOM 7510 N LYS E 123 -9.393 69.248 3.582 1.00 18.40 N +ATOM 7511 CA LYS E 123 -9.262 70.192 2.466 1.00 16.10 C +ATOM 7512 C LYS E 123 -10.629 70.783 2.127 1.00 17.05 C +ATOM 7513 O LYS E 123 -11.644 70.098 2.198 1.00 25.40 O +ATOM 7514 CB LYS E 123 -8.700 69.516 1.221 1.00 8.50 C +ATOM 7515 CG LYS E 123 -8.573 70.471 0.065 1.00 13.19 C +ATOM 7516 CD LYS E 123 -8.657 69.790 -1.292 1.00 22.06 C +ATOM 7517 CE LYS E 123 -7.354 69.142 -1.694 1.00 8.76 C +ATOM 7518 NZ LYS E 123 -7.399 68.791 -3.126 1.00 8.50 N +ATOM 7519 N GLY E 124 -10.652 72.059 1.783 1.00 17.74 N +ATOM 7520 CA GLY E 124 -11.895 72.715 1.442 1.00 18.78 C +ATOM 7521 C GLY E 124 -12.761 73.110 2.625 1.00 22.42 C +ATOM 7522 O GLY E 124 -13.701 73.897 2.472 1.00 29.71 O +ATOM 7523 N TYR E 125 -12.469 72.572 3.806 1.00 18.64 N +ATOM 7524 CA TYR E 125 -13.249 72.900 5.003 1.00 20.57 C +ATOM 7525 C TYR E 125 -13.038 74.385 5.337 1.00 24.71 C +ATOM 7526 O TYR E 125 -12.206 75.070 4.716 1.00 25.65 O +ATOM 7527 CB TYR E 125 -12.799 72.022 6.191 1.00 21.19 C +ATOM 7528 CG TYR E 125 -13.644 72.135 7.443 1.00 15.36 C +ATOM 7529 CD1 TYR E 125 -14.845 71.466 7.552 1.00 22.64 C +ATOM 7530 CD2 TYR E 125 -13.238 72.922 8.513 1.00 24.72 C +ATOM 7531 CE1 TYR E 125 -15.627 71.579 8.697 1.00 33.54 C +ATOM 7532 CE2 TYR E 125 -14.013 73.043 9.669 1.00 26.84 C +ATOM 7533 CZ TYR E 125 -15.206 72.374 9.759 1.00 28.14 C +ATOM 7534 OH TYR E 125 -15.985 72.498 10.897 1.00 17.33 O +ATOM 7535 N THR E 126 -13.813 74.886 6.295 1.00 24.40 N +ATOM 7536 CA THR E 126 -13.704 76.271 6.725 1.00 23.13 C +ATOM 7537 C THR E 126 -14.081 76.347 8.210 1.00 24.24 C +ATOM 7538 O THR E 126 -15.178 75.933 8.617 1.00 22.13 O +ATOM 7539 CB THR E 126 -14.543 77.212 5.809 1.00 20.76 C +ATOM 7540 OG1 THR E 126 -14.790 78.456 6.472 1.00 32.40 O +ATOM 7541 CG2 THR E 126 -15.856 76.556 5.380 1.00 28.86 C +ATOM 7542 N VAL E 127 -13.116 76.785 9.022 1.00 24.40 N +ATOM 7543 CA VAL E 127 -13.280 76.877 10.479 1.00 18.06 C +ATOM 7544 C VAL E 127 -14.217 78.000 10.914 1.00 17.22 C +ATOM 7545 O VAL E 127 -14.162 79.105 10.388 1.00 17.76 O +ATOM 7546 CB VAL E 127 -11.901 77.010 11.176 1.00 9.62 C +ATOM 7547 CG1 VAL E 127 -12.066 77.193 12.649 1.00 14.48 C +ATOM 7548 CG2 VAL E 127 -11.061 75.778 10.905 1.00 10.21 C +ATOM 7549 N GLY E 128 -15.075 77.703 11.880 1.00 19.32 N +ATOM 7550 CA GLY E 128 -16.034 78.674 12.388 1.00 25.46 C +ATOM 7551 C GLY E 128 -15.402 79.868 13.067 1.00 28.11 C +ATOM 7552 O GLY E 128 -14.415 79.722 13.782 1.00 30.16 O +ATOM 7553 N ALA E 129 -16.013 81.037 12.881 1.00 32.18 N +ATOM 7554 CA ALA E 129 -15.511 82.295 13.432 1.00 32.66 C +ATOM 7555 C ALA E 129 -15.837 82.579 14.891 1.00 39.76 C +ATOM 7556 O ALA E 129 -15.028 83.178 15.601 1.00 45.02 O +ATOM 7557 CB ALA E 129 -15.970 83.449 12.567 1.00 33.02 C +ATOM 7558 N GLU E 130 -17.039 82.227 15.332 1.00 43.92 N +ATOM 7559 CA GLU E 130 -17.404 82.458 16.729 1.00 50.20 C +ATOM 7560 C GLU E 130 -17.085 81.190 17.507 1.00 45.92 C +ATOM 7561 O GLU E 130 -17.740 80.155 17.325 1.00 44.73 O +ATOM 7562 CB GLU E 130 -18.878 82.846 16.864 1.00 60.87 C +ATOM 7563 CG GLU E 130 -19.858 81.890 16.232 1.00 86.68 C +ATOM 7564 CD GLU E 130 -21.289 82.340 16.416 1.00 99.70 C +ATOM 7565 OE1 GLU E 130 -21.776 83.113 15.561 1.00106.43 O +ATOM 7566 OE2 GLU E 130 -21.921 81.930 17.420 1.00107.13 O +ATOM 7567 N ALA E 131 -16.075 81.268 18.369 1.00 41.65 N +ATOM 7568 CA ALA E 131 -15.661 80.094 19.111 1.00 31.87 C +ATOM 7569 C ALA E 131 -15.243 80.330 20.547 1.00 23.88 C +ATOM 7570 O ALA E 131 -14.917 81.449 20.951 1.00 25.84 O +ATOM 7571 CB ALA E 131 -14.532 79.396 18.355 1.00 31.12 C +ATOM 7572 N SER E 132 -15.264 79.240 21.303 1.00 18.01 N +ATOM 7573 CA SER E 132 -14.857 79.226 22.691 1.00 21.77 C +ATOM 7574 C SER E 132 -13.492 78.542 22.656 1.00 22.71 C +ATOM 7575 O SER E 132 -13.387 77.394 22.233 1.00 21.83 O +ATOM 7576 CB SER E 132 -15.842 78.406 23.528 1.00 16.87 C +ATOM 7577 OG SER E 132 -15.426 78.335 24.885 1.00 25.38 O +ATOM 7578 N ILE E 133 -12.452 79.285 23.019 1.00 21.24 N +ATOM 7579 CA ILE E 133 -11.079 78.788 23.038 1.00 13.59 C +ATOM 7580 C ILE E 133 -10.669 78.573 24.494 1.00 14.31 C +ATOM 7581 O ILE E 133 -10.583 79.525 25.272 1.00 22.29 O +ATOM 7582 CB ILE E 133 -10.128 79.813 22.375 1.00 13.31 C +ATOM 7583 CG1 ILE E 133 -10.643 80.176 20.977 1.00 15.79 C +ATOM 7584 CG2 ILE E 133 -8.712 79.274 22.304 1.00 8.50 C +ATOM 7585 CD1 ILE E 133 -9.841 81.245 20.266 1.00 8.50 C +ATOM 7586 N ILE E 134 -10.404 77.332 24.868 1.00 8.71 N +ATOM 7587 CA ILE E 134 -10.038 77.044 26.240 1.00 11.43 C +ATOM 7588 C ILE E 134 -8.698 76.361 26.417 1.00 11.95 C +ATOM 7589 O ILE E 134 -8.299 75.512 25.627 1.00 14.19 O +ATOM 7590 CB ILE E 134 -11.171 76.271 26.957 1.00 14.83 C +ATOM 7591 CG1 ILE E 134 -12.304 77.246 27.281 1.00 15.40 C +ATOM 7592 CG2 ILE E 134 -10.669 75.558 28.198 1.00 8.50 C +ATOM 7593 CD1 ILE E 134 -13.474 76.620 27.956 1.00 29.64 C +ATOM 7594 N LEU E 135 -8.008 76.766 27.472 1.00 10.47 N +ATOM 7595 CA LEU E 135 -6.706 76.247 27.815 1.00 10.95 C +ATOM 7596 C LEU E 135 -6.817 75.388 29.055 1.00 12.75 C +ATOM 7597 O LEU E 135 -7.460 75.783 30.019 1.00 11.33 O +ATOM 7598 CB LEU E 135 -5.747 77.414 28.089 1.00 8.50 C +ATOM 7599 CG LEU E 135 -4.780 77.885 27.004 1.00 8.50 C +ATOM 7600 CD1 LEU E 135 -5.413 77.814 25.616 1.00 8.83 C +ATOM 7601 CD2 LEU E 135 -4.316 79.279 27.338 1.00 8.50 C +ATOM 7602 N GLY E 136 -6.216 74.202 29.018 1.00 18.95 N +ATOM 7603 CA GLY E 136 -6.239 73.332 30.188 1.00 25.63 C +ATOM 7604 C GLY E 136 -7.360 72.311 30.358 1.00 25.70 C +ATOM 7605 O GLY E 136 -7.251 71.436 31.207 1.00 24.49 O +ATOM 7606 N GLN E 137 -8.450 72.444 29.612 1.00 21.61 N +ATOM 7607 CA GLN E 137 -9.564 71.508 29.694 1.00 13.78 C +ATOM 7608 C GLN E 137 -9.973 71.057 28.313 1.00 17.98 C +ATOM 7609 O GLN E 137 -9.690 71.733 27.325 1.00 22.84 O +ATOM 7610 CB GLN E 137 -10.777 72.144 30.373 1.00 17.23 C +ATOM 7611 CG GLN E 137 -10.713 72.143 31.878 1.00 21.48 C +ATOM 7612 CD GLN E 137 -10.440 70.761 32.466 1.00 32.47 C +ATOM 7613 OE1 GLN E 137 -9.936 70.649 33.586 1.00 31.39 O +ATOM 7614 NE2 GLN E 137 -10.778 69.703 31.721 1.00 25.69 N +ATOM 7615 N GLU E 138 -10.661 69.926 28.236 1.00 18.53 N +ATOM 7616 CA GLU E 138 -11.105 69.423 26.946 1.00 18.35 C +ATOM 7617 C GLU E 138 -12.580 69.702 26.729 1.00 19.99 C +ATOM 7618 O GLU E 138 -13.421 69.130 27.403 1.00 25.02 O +ATOM 7619 CB GLU E 138 -10.854 67.935 26.844 1.00 19.71 C +ATOM 7620 CG GLU E 138 -10.670 67.439 25.409 1.00 34.48 C +ATOM 7621 CD GLU E 138 -11.956 67.425 24.573 1.00 42.59 C +ATOM 7622 OE1 GLU E 138 -12.719 66.428 24.639 1.00 49.35 O +ATOM 7623 OE2 GLU E 138 -12.179 68.394 23.816 1.00 32.75 O +ATOM 7624 N GLN E 139 -12.884 70.573 25.775 1.00 21.82 N +ATOM 7625 CA GLN E 139 -14.256 70.936 25.464 1.00 23.32 C +ATOM 7626 C GLN E 139 -15.019 69.867 24.699 1.00 35.15 C +ATOM 7627 O GLN E 139 -14.519 69.292 23.723 1.00 37.81 O +ATOM 7628 CB GLN E 139 -14.289 72.233 24.669 1.00 21.29 C +ATOM 7629 CG GLN E 139 -14.570 73.460 25.488 1.00 17.95 C +ATOM 7630 CD GLN E 139 -14.159 74.697 24.769 1.00 16.56 C +ATOM 7631 OE1 GLN E 139 -13.008 75.104 24.856 1.00 39.08 O +ATOM 7632 NE2 GLN E 139 -15.072 75.285 24.018 1.00 8.50 N +ATOM 7633 N ASP E 140 -16.242 69.613 25.148 1.00 38.49 N +ATOM 7634 CA ASP E 140 -17.113 68.637 24.518 1.00 42.83 C +ATOM 7635 C ASP E 140 -18.471 69.274 24.281 1.00 45.51 C +ATOM 7636 O ASP E 140 -19.441 68.610 23.906 1.00 54.70 O +ATOM 7637 CB ASP E 140 -17.208 67.362 25.361 1.00 44.35 C +ATOM 7638 CG ASP E 140 -15.932 66.535 25.299 1.00 48.12 C +ATOM 7639 OD1 ASP E 140 -15.346 66.447 24.198 1.00 48.52 O +ATOM 7640 OD2 ASP E 140 -15.502 65.996 26.344 1.00 46.72 O +ATOM 7641 N SER E 141 -18.516 70.581 24.501 1.00 41.73 N +ATOM 7642 CA SER E 141 -19.701 71.399 24.280 1.00 42.37 C +ATOM 7643 C SER E 141 -19.174 72.828 24.338 1.00 40.30 C +ATOM 7644 O SER E 141 -18.147 73.093 24.978 1.00 41.73 O +ATOM 7645 CB SER E 141 -20.771 71.177 25.352 1.00 38.35 C +ATOM 7646 OG SER E 141 -20.493 71.908 26.534 1.00 49.07 O +ATOM 7647 N PHE E 142 -19.845 73.738 23.646 1.00 33.41 N +ATOM 7648 CA PHE E 142 -19.419 75.123 23.622 1.00 32.24 C +ATOM 7649 C PHE E 142 -19.172 75.688 25.022 1.00 34.07 C +ATOM 7650 O PHE E 142 -20.107 76.010 25.745 1.00 38.94 O +ATOM 7651 CB PHE E 142 -20.450 75.962 22.874 1.00 32.31 C +ATOM 7652 CG PHE E 142 -19.965 77.327 22.491 1.00 32.21 C +ATOM 7653 CD1 PHE E 142 -19.275 77.528 21.301 1.00 33.66 C +ATOM 7654 CD2 PHE E 142 -20.232 78.419 23.303 1.00 46.71 C +ATOM 7655 CE1 PHE E 142 -18.859 78.800 20.920 1.00 50.84 C +ATOM 7656 CE2 PHE E 142 -19.823 79.703 22.937 1.00 60.07 C +ATOM 7657 CZ PHE E 142 -19.134 79.895 21.739 1.00 58.48 C +ATOM 7658 N GLY E 143 -17.899 75.764 25.402 1.00 38.35 N +ATOM 7659 CA GLY E 143 -17.521 76.312 26.692 1.00 34.48 C +ATOM 7660 C GLY E 143 -17.726 75.425 27.897 1.00 36.20 C +ATOM 7661 O GLY E 143 -17.647 75.918 29.023 1.00 38.01 O +ATOM 7662 N GLY E 144 -17.940 74.128 27.680 1.00 35.18 N +ATOM 7663 CA GLY E 144 -18.151 73.228 28.797 1.00 40.36 C +ATOM 7664 C GLY E 144 -17.992 71.742 28.512 1.00 46.19 C +ATOM 7665 O GLY E 144 -17.423 71.342 27.482 1.00 45.84 O +ATOM 7666 N ASN E 145 -18.523 70.929 29.435 1.00 52.44 N +ATOM 7667 CA ASN E 145 -18.473 69.463 29.372 1.00 49.61 C +ATOM 7668 C ASN E 145 -17.024 68.993 29.456 1.00 44.02 C +ATOM 7669 O ASN E 145 -16.513 68.307 28.568 1.00 41.23 O +ATOM 7670 CB ASN E 145 -19.167 68.932 28.107 1.00 58.03 C +ATOM 7671 CG ASN E 145 -20.684 68.876 28.247 1.00 69.21 C +ATOM 7672 OD1 ASN E 145 -21.350 69.899 28.458 1.00 78.07 O +ATOM 7673 ND2 ASN E 145 -21.239 67.678 28.122 1.00 74.71 N +ATOM 7674 N PHE E 146 -16.386 69.348 30.566 1.00 38.96 N +ATOM 7675 CA PHE E 146 -14.993 69.010 30.800 1.00 42.58 C +ATOM 7676 C PHE E 146 -14.764 67.642 31.428 1.00 45.89 C +ATOM 7677 O PHE E 146 -15.324 67.334 32.480 1.00 46.31 O +ATOM 7678 CB PHE E 146 -14.338 70.077 31.679 1.00 23.64 C +ATOM 7679 CG PHE E 146 -14.482 71.472 31.145 1.00 23.68 C +ATOM 7680 CD1 PHE E 146 -14.368 71.735 29.781 1.00 25.65 C +ATOM 7681 CD2 PHE E 146 -14.739 72.528 32.003 1.00 19.66 C +ATOM 7682 CE1 PHE E 146 -14.511 73.024 29.289 1.00 15.96 C +ATOM 7683 CE2 PHE E 146 -14.882 73.808 31.523 1.00 8.68 C +ATOM 7684 CZ PHE E 146 -14.768 74.058 30.165 1.00 16.93 C +ATOM 7685 N GLU E 147 -13.949 66.824 30.768 1.00 46.74 N +ATOM 7686 CA GLU E 147 -13.599 65.510 31.283 1.00 49.89 C +ATOM 7687 C GLU E 147 -12.261 65.679 31.995 1.00 48.31 C +ATOM 7688 O GLU E 147 -11.270 66.072 31.379 1.00 49.30 O +ATOM 7689 CB GLU E 147 -13.468 64.502 30.135 1.00 67.20 C +ATOM 7690 CG GLU E 147 -14.338 63.247 30.303 1.00 78.86 C +ATOM 7691 CD GLU E 147 -15.184 62.937 29.067 1.00 76.66 C +ATOM 7692 OE1 GLU E 147 -16.304 63.496 28.937 1.00 60.37 O +ATOM 7693 OE2 GLU E 147 -14.727 62.125 28.229 1.00 73.71 O +ATOM 7694 N GLY E 148 -12.249 65.411 33.298 1.00 50.44 N +ATOM 7695 CA GLY E 148 -11.040 65.551 34.103 1.00 46.54 C +ATOM 7696 C GLY E 148 -9.892 64.644 33.713 1.00 42.71 C +ATOM 7697 O GLY E 148 -8.739 64.878 34.091 1.00 40.65 O +ATOM 7698 N SER E 149 -10.221 63.601 32.956 1.00 41.95 N +ATOM 7699 CA SER E 149 -9.236 62.630 32.475 1.00 46.41 C +ATOM 7700 C SER E 149 -8.426 63.214 31.295 1.00 44.05 C +ATOM 7701 O SER E 149 -7.496 62.571 30.770 1.00 43.89 O +ATOM 7702 CB SER E 149 -9.972 61.352 32.032 1.00 52.75 C +ATOM 7703 OG SER E 149 -9.078 60.315 31.644 1.00 71.87 O +ATOM 7704 N GLN E 150 -8.790 64.436 30.893 1.00 35.57 N +ATOM 7705 CA GLN E 150 -8.158 65.113 29.773 1.00 23.64 C +ATOM 7706 C GLN E 150 -7.747 66.526 30.164 1.00 29.05 C +ATOM 7707 O GLN E 150 -7.538 67.387 29.304 1.00 36.73 O +ATOM 7708 CB GLN E 150 -9.135 65.141 28.590 1.00 22.83 C +ATOM 7709 CG GLN E 150 -9.818 63.786 28.319 1.00 26.76 C +ATOM 7710 CD GLN E 150 -10.584 63.741 27.007 1.00 40.80 C +ATOM 7711 OE1 GLN E 150 -11.521 64.519 26.785 1.00 34.48 O +ATOM 7712 NE2 GLN E 150 -10.210 62.798 26.137 1.00 54.11 N +ATOM 7713 N SER E 151 -7.645 66.770 31.465 1.00 27.85 N +ATOM 7714 CA SER E 151 -7.251 68.075 31.952 1.00 22.65 C +ATOM 7715 C SER E 151 -5.737 68.189 31.870 1.00 20.57 C +ATOM 7716 O SER E 151 -5.039 67.182 31.776 1.00 20.85 O +ATOM 7717 CB SER E 151 -7.709 68.254 33.389 1.00 24.73 C +ATOM 7718 OG SER E 151 -7.386 69.554 33.855 1.00 55.45 O +ATOM 7719 N LEU E 152 -5.224 69.414 31.854 1.00 22.17 N +ATOM 7720 CA LEU E 152 -3.779 69.590 31.799 1.00 14.55 C +ATOM 7721 C LEU E 152 -3.243 69.947 33.167 1.00 11.45 C +ATOM 7722 O LEU E 152 -3.809 70.788 33.860 1.00 10.22 O +ATOM 7723 CB LEU E 152 -3.397 70.690 30.814 1.00 14.58 C +ATOM 7724 CG LEU E 152 -1.927 71.094 30.838 1.00 8.50 C +ATOM 7725 CD1 LEU E 152 -1.090 70.090 30.093 1.00 10.45 C +ATOM 7726 CD2 LEU E 152 -1.785 72.454 30.218 1.00 14.82 C +ATOM 7727 N VAL E 153 -2.166 69.281 33.562 1.00 9.90 N +ATOM 7728 CA VAL E 153 -1.544 69.554 34.841 1.00 9.26 C +ATOM 7729 C VAL E 153 -0.106 69.929 34.542 1.00 12.39 C +ATOM 7730 O VAL E 153 0.688 69.083 34.120 1.00 10.90 O +ATOM 7731 CB VAL E 153 -1.564 68.336 35.758 1.00 10.21 C +ATOM 7732 CG1 VAL E 153 -1.162 68.755 37.165 1.00 21.72 C +ATOM 7733 CG2 VAL E 153 -2.935 67.677 35.758 1.00 13.28 C +ATOM 7734 N GLY E 154 0.193 71.213 34.710 1.00 11.38 N +ATOM 7735 CA GLY E 154 1.516 71.739 34.438 1.00 10.39 C +ATOM 7736 C GLY E 154 1.410 73.193 34.011 1.00 14.21 C +ATOM 7737 O GLY E 154 0.461 73.883 34.384 1.00 15.32 O +ATOM 7738 N ASP E 155 2.365 73.664 33.219 1.00 11.01 N +ATOM 7739 CA ASP E 155 2.371 75.051 32.772 1.00 8.50 C +ATOM 7740 C ASP E 155 2.098 75.134 31.299 1.00 9.60 C +ATOM 7741 O ASP E 155 2.456 74.230 30.545 1.00 13.51 O +ATOM 7742 CB ASP E 155 3.739 75.692 33.007 1.00 8.50 C +ATOM 7743 CG ASP E 155 4.054 75.888 34.467 1.00 9.52 C +ATOM 7744 OD1 ASP E 155 4.027 74.906 35.236 1.00 12.01 O +ATOM 7745 OD2 ASP E 155 4.358 77.032 34.845 1.00 12.59 O +ATOM 7746 N ILE E 156 1.496 76.236 30.883 1.00 8.50 N +ATOM 7747 CA ILE E 156 1.229 76.473 29.476 1.00 9.69 C +ATOM 7748 C ILE E 156 1.341 77.975 29.286 1.00 12.17 C +ATOM 7749 O ILE E 156 0.907 78.749 30.137 1.00 17.56 O +ATOM 7750 CB ILE E 156 -0.150 75.968 29.042 1.00 8.50 C +ATOM 7751 CG1 ILE E 156 -0.320 76.197 27.554 1.00 8.99 C +ATOM 7752 CG2 ILE E 156 -1.245 76.693 29.783 1.00 8.50 C +ATOM 7753 CD1 ILE E 156 -1.601 75.637 27.032 1.00 23.50 C +ATOM 7754 N GLY E 157 1.972 78.390 28.205 1.00 9.41 N +ATOM 7755 CA GLY E 157 2.142 79.801 27.972 1.00 8.50 C +ATOM 7756 C GLY E 157 2.547 80.072 26.545 1.00 10.55 C +ATOM 7757 O GLY E 157 2.616 79.169 25.726 1.00 12.52 O +ATOM 7758 N ASN E 158 2.832 81.332 26.264 1.00 14.17 N +ATOM 7759 CA ASN E 158 3.212 81.789 24.941 1.00 8.50 C +ATOM 7760 C ASN E 158 2.311 81.335 23.820 1.00 8.50 C +ATOM 7761 O ASN E 158 2.797 80.964 22.765 1.00 8.50 O +ATOM 7762 CB ASN E 158 4.648 81.428 24.633 1.00 8.50 C +ATOM 7763 CG ASN E 158 5.613 82.440 25.151 1.00 15.12 C +ATOM 7764 OD1 ASN E 158 6.531 82.093 25.865 1.00 25.40 O +ATOM 7765 ND2 ASN E 158 5.423 83.705 24.788 1.00 25.90 N +ATOM 7766 N VAL E 159 1.000 81.370 24.041 1.00 8.50 N +ATOM 7767 CA VAL E 159 0.061 80.970 22.991 1.00 11.06 C +ATOM 7768 C VAL E 159 -0.229 82.161 22.088 1.00 8.87 C +ATOM 7769 O VAL E 159 -0.466 83.264 22.564 1.00 11.78 O +ATOM 7770 CB VAL E 159 -1.250 80.308 23.549 1.00 9.47 C +ATOM 7771 CG1 VAL E 159 -1.327 80.425 25.059 1.00 8.50 C +ATOM 7772 CG2 VAL E 159 -2.479 80.887 22.895 1.00 8.50 C +ATOM 7773 N ASN E 160 -0.100 81.950 20.788 1.00 8.50 N +ATOM 7774 CA ASN E 160 -0.330 82.988 19.788 1.00 10.04 C +ATOM 7775 C ASN E 160 -1.011 82.294 18.616 1.00 11.83 C +ATOM 7776 O ASN E 160 -0.851 81.091 18.448 1.00 15.82 O +ATOM 7777 CB ASN E 160 0.986 83.618 19.325 1.00 8.50 C +ATOM 7778 CG ASN E 160 1.707 84.360 20.427 1.00 8.50 C +ATOM 7779 OD1 ASN E 160 2.630 83.842 21.034 1.00 25.87 O +ATOM 7780 ND2 ASN E 160 1.321 85.592 20.661 1.00 8.50 N +ATOM 7781 N MET E 161 -1.745 83.041 17.802 1.00 8.50 N +ATOM 7782 CA MET E 161 -2.460 82.466 16.683 1.00 8.50 C +ATOM 7783 C MET E 161 -2.580 83.458 15.550 1.00 10.75 C +ATOM 7784 O MET E 161 -2.888 84.634 15.771 1.00 11.74 O +ATOM 7785 CB MET E 161 -3.850 82.034 17.145 1.00 8.50 C +ATOM 7786 CG MET E 161 -4.698 81.332 16.103 1.00 13.82 C +ATOM 7787 SD MET E 161 -6.202 80.629 16.832 1.00 8.50 S +ATOM 7788 CE MET E 161 -6.818 79.666 15.443 1.00 14.04 C +ATOM 7789 N TRP E 162 -2.325 82.983 14.335 1.00 11.30 N +ATOM 7790 CA TRP E 162 -2.405 83.805 13.140 1.00 9.93 C +ATOM 7791 C TRP E 162 -3.513 83.227 12.275 1.00 11.93 C +ATOM 7792 O TRP E 162 -3.843 82.051 12.422 1.00 13.93 O +ATOM 7793 CB TRP E 162 -1.095 83.739 12.373 1.00 8.50 C +ATOM 7794 CG TRP E 162 0.100 84.320 13.067 1.00 8.50 C +ATOM 7795 CD1 TRP E 162 0.721 85.502 12.779 1.00 8.72 C +ATOM 7796 CD2 TRP E 162 0.871 83.710 14.100 1.00 8.50 C +ATOM 7797 NE1 TRP E 162 1.832 85.656 13.561 1.00 8.50 N +ATOM 7798 CE2 TRP E 162 1.947 84.568 14.382 1.00 8.50 C +ATOM 7799 CE3 TRP E 162 0.758 82.518 14.817 1.00 10.64 C +ATOM 7800 CZ2 TRP E 162 2.903 84.268 15.347 1.00 11.38 C +ATOM 7801 CZ3 TRP E 162 1.708 82.224 15.776 1.00 8.50 C +ATOM 7802 CH2 TRP E 162 2.766 83.091 16.033 1.00 8.50 C +ATOM 7803 N ASP E 163 -4.099 84.044 11.396 1.00 11.33 N +ATOM 7804 CA ASP E 163 -5.163 83.565 10.513 1.00 10.61 C +ATOM 7805 C ASP E 163 -4.620 83.103 9.164 1.00 12.12 C +ATOM 7806 O ASP E 163 -5.379 82.879 8.223 1.00 16.10 O +ATOM 7807 CB ASP E 163 -6.282 84.605 10.335 1.00 10.10 C +ATOM 7808 CG ASP E 163 -5.817 85.894 9.649 1.00 22.44 C +ATOM 7809 OD1 ASP E 163 -4.830 85.885 8.883 1.00 26.79 O +ATOM 7810 OD2 ASP E 163 -6.475 86.935 9.867 1.00 29.52 O +ATOM 7811 N PHE E 164 -3.296 83.011 9.067 1.00 8.50 N +ATOM 7812 CA PHE E 164 -2.619 82.572 7.852 1.00 8.50 C +ATOM 7813 C PHE E 164 -1.513 81.590 8.226 1.00 9.28 C +ATOM 7814 O PHE E 164 -1.212 81.419 9.402 1.00 13.68 O +ATOM 7815 CB PHE E 164 -2.060 83.762 7.056 1.00 11.06 C +ATOM 7816 CG PHE E 164 -1.013 84.584 7.783 1.00 8.50 C +ATOM 7817 CD1 PHE E 164 -1.380 85.617 8.616 1.00 8.50 C +ATOM 7818 CD2 PHE E 164 0.331 84.326 7.615 1.00 8.50 C +ATOM 7819 CE1 PHE E 164 -0.429 86.360 9.262 1.00 9.29 C +ATOM 7820 CE2 PHE E 164 1.292 85.071 8.265 1.00 8.50 C +ATOM 7821 CZ PHE E 164 0.917 86.082 9.085 1.00 8.50 C +ATOM 7822 N VAL E 165 -0.901 80.951 7.238 1.00 9.12 N +ATOM 7823 CA VAL E 165 0.141 79.966 7.495 1.00 8.50 C +ATOM 7824 C VAL E 165 1.545 80.532 7.544 1.00 8.50 C +ATOM 7825 O VAL E 165 2.055 81.039 6.553 1.00 11.67 O +ATOM 7826 CB VAL E 165 0.098 78.832 6.454 1.00 8.50 C +ATOM 7827 CG1 VAL E 165 1.107 77.753 6.802 1.00 17.56 C +ATOM 7828 CG2 VAL E 165 -1.308 78.242 6.375 1.00 8.50 C +ATOM 7829 N LEU E 166 2.175 80.428 8.703 1.00 8.50 N +ATOM 7830 CA LEU E 166 3.532 80.909 8.885 1.00 8.50 C +ATOM 7831 C LEU E 166 4.506 80.095 8.033 1.00 8.50 C +ATOM 7832 O LEU E 166 4.326 78.895 7.825 1.00 8.50 O +ATOM 7833 CB LEU E 166 3.932 80.805 10.347 1.00 8.50 C +ATOM 7834 CG LEU E 166 3.906 82.060 11.188 1.00 8.50 C +ATOM 7835 CD1 LEU E 166 2.592 82.733 11.022 1.00 8.50 C +ATOM 7836 CD2 LEU E 166 4.160 81.699 12.647 1.00 14.93 C +ATOM 7837 N SER E 167 5.530 80.763 7.521 1.00 10.55 N +ATOM 7838 CA SER E 167 6.535 80.106 6.705 1.00 10.54 C +ATOM 7839 C SER E 167 7.581 79.517 7.624 1.00 11.46 C +ATOM 7840 O SER E 167 7.645 79.838 8.810 1.00 12.49 O +ATOM 7841 CB SER E 167 7.197 81.094 5.730 1.00 10.12 C +ATOM 7842 OG SER E 167 8.073 82.002 6.374 1.00 23.63 O +ATOM 7843 N PRO E 168 8.434 78.648 7.087 1.00 9.39 N +ATOM 7844 CA PRO E 168 9.481 78.023 7.888 1.00 8.55 C +ATOM 7845 C PRO E 168 10.362 79.040 8.583 1.00 15.29 C +ATOM 7846 O PRO E 168 10.740 78.853 9.740 1.00 23.76 O +ATOM 7847 CB PRO E 168 10.262 77.241 6.853 1.00 8.50 C +ATOM 7848 CG PRO E 168 9.196 76.840 5.896 1.00 9.55 C +ATOM 7849 CD PRO E 168 8.410 78.086 5.730 1.00 8.50 C +ATOM 7850 N ASP E 169 10.669 80.133 7.887 1.00 17.28 N +ATOM 7851 CA ASP E 169 11.526 81.176 8.439 1.00 16.39 C +ATOM 7852 C ASP E 169 10.832 81.913 9.578 1.00 15.01 C +ATOM 7853 O ASP E 169 11.441 82.194 10.617 1.00 22.06 O +ATOM 7854 CB ASP E 169 11.964 82.143 7.350 1.00 15.49 C +ATOM 7855 CG ASP E 169 12.752 81.465 6.242 1.00 18.08 C +ATOM 7856 OD1 ASP E 169 13.871 80.978 6.512 1.00 18.32 O +ATOM 7857 OD2 ASP E 169 12.254 81.437 5.093 1.00 23.81 O +ATOM 7858 N GLU E 170 9.548 82.183 9.407 1.00 8.50 N +ATOM 7859 CA GLU E 170 8.797 82.864 10.440 1.00 8.50 C +ATOM 7860 C GLU E 170 8.689 81.917 11.637 1.00 12.46 C +ATOM 7861 O GLU E 170 9.089 82.264 12.745 1.00 13.64 O +ATOM 7862 CB GLU E 170 7.413 83.259 9.926 1.00 8.50 C +ATOM 7863 CG GLU E 170 7.451 84.084 8.654 1.00 18.53 C +ATOM 7864 CD GLU E 170 6.073 84.534 8.166 1.00 28.29 C +ATOM 7865 OE1 GLU E 170 5.414 85.317 8.877 1.00 42.12 O +ATOM 7866 OE2 GLU E 170 5.650 84.131 7.062 1.00 25.69 O +ATOM 7867 N ILE E 171 8.250 80.685 11.391 1.00 14.01 N +ATOM 7868 CA ILE E 171 8.111 79.693 12.457 1.00 12.61 C +ATOM 7869 C ILE E 171 9.422 79.563 13.204 1.00 11.58 C +ATOM 7870 O ILE E 171 9.452 79.292 14.398 1.00 11.24 O +ATOM 7871 CB ILE E 171 7.686 78.324 11.909 1.00 8.50 C +ATOM 7872 CG1 ILE E 171 6.232 78.407 11.457 1.00 10.76 C +ATOM 7873 CG2 ILE E 171 7.817 77.274 12.965 1.00 8.50 C +ATOM 7874 CD1 ILE E 171 5.655 77.151 10.908 1.00 21.09 C +ATOM 7875 N ASN E 172 10.508 79.808 12.498 1.00 13.53 N +ATOM 7876 CA ASN E 172 11.796 79.718 13.104 1.00 18.20 C +ATOM 7877 C ASN E 172 12.045 80.890 14.017 1.00 13.22 C +ATOM 7878 O ASN E 172 12.439 80.693 15.165 1.00 24.12 O +ATOM 7879 CB ASN E 172 12.898 79.603 12.066 1.00 26.46 C +ATOM 7880 CG ASN E 172 14.232 79.346 12.695 1.00 44.27 C +ATOM 7881 OD1 ASN E 172 15.051 80.261 12.824 1.00 51.31 O +ATOM 7882 ND2 ASN E 172 14.439 78.115 13.173 1.00 45.43 N +ATOM 7883 N THR E 173 11.798 82.106 13.558 1.00 8.50 N +ATOM 7884 CA THR E 173 12.026 83.245 14.453 1.00 12.94 C +ATOM 7885 C THR E 173 11.102 83.161 15.685 1.00 10.31 C +ATOM 7886 O THR E 173 11.541 83.426 16.797 1.00 10.96 O +ATOM 7887 CB THR E 173 11.888 84.646 13.769 1.00 13.61 C +ATOM 7888 OG1 THR E 173 10.533 85.103 13.848 1.00 11.32 O +ATOM 7889 CG2 THR E 173 12.341 84.600 12.322 1.00 15.75 C +ATOM 7890 N ILE E 174 9.854 82.741 15.505 1.00 8.50 N +ATOM 7891 CA ILE E 174 8.967 82.611 16.639 1.00 8.50 C +ATOM 7892 C ILE E 174 9.645 81.729 17.668 1.00 8.50 C +ATOM 7893 O ILE E 174 9.697 82.071 18.842 1.00 9.57 O +ATOM 7894 CB ILE E 174 7.616 81.996 16.276 1.00 8.50 C +ATOM 7895 CG1 ILE E 174 6.672 83.035 15.696 1.00 8.50 C +ATOM 7896 CG2 ILE E 174 6.940 81.454 17.494 1.00 9.50 C +ATOM 7897 CD1 ILE E 174 6.926 83.383 14.296 1.00 12.39 C +ATOM 7898 N TYR E 175 10.202 80.613 17.224 1.00 8.50 N +ATOM 7899 CA TYR E 175 10.874 79.685 18.125 1.00 9.44 C +ATOM 7900 C TYR E 175 12.076 80.292 18.821 1.00 17.04 C +ATOM 7901 O TYR E 175 12.224 80.197 20.042 1.00 25.38 O +ATOM 7902 CB TYR E 175 11.329 78.425 17.387 1.00 8.50 C +ATOM 7903 CG TYR E 175 12.117 77.467 18.260 1.00 8.90 C +ATOM 7904 CD1 TYR E 175 11.620 77.046 19.501 1.00 12.28 C +ATOM 7905 CD2 TYR E 175 13.353 76.984 17.848 1.00 9.29 C +ATOM 7906 CE1 TYR E 175 12.336 76.175 20.303 1.00 18.53 C +ATOM 7907 CE2 TYR E 175 14.077 76.103 18.642 1.00 23.00 C +ATOM 7908 CZ TYR E 175 13.565 75.703 19.865 1.00 27.70 C +ATOM 7909 OH TYR E 175 14.273 74.816 20.643 1.00 43.52 O +ATOM 7910 N LEU E 176 12.947 80.890 18.025 1.00 19.41 N +ATOM 7911 CA LEU E 176 14.177 81.506 18.499 1.00 19.73 C +ATOM 7912 C LEU E 176 14.011 82.780 19.299 1.00 25.08 C +ATOM 7913 O LEU E 176 14.991 83.313 19.830 1.00 24.83 O +ATOM 7914 CB LEU E 176 15.087 81.785 17.316 1.00 14.21 C +ATOM 7915 CG LEU E 176 16.286 80.861 17.176 1.00 21.32 C +ATOM 7916 CD1 LEU E 176 16.080 79.548 17.937 1.00 28.64 C +ATOM 7917 CD2 LEU E 176 16.517 80.638 15.693 1.00 23.28 C +ATOM 7918 N GLY E 177 12.785 83.284 19.361 1.00 28.82 N +ATOM 7919 CA GLY E 177 12.531 84.501 20.115 1.00 35.05 C +ATOM 7920 C GLY E 177 12.819 85.745 19.310 1.00 36.37 C +ATOM 7921 O GLY E 177 13.653 86.561 19.675 1.00 43.81 O +ATOM 7922 N GLY E 178 12.170 85.852 18.163 1.00 40.23 N +ATOM 7923 CA GLY E 178 12.349 87.018 17.330 1.00 37.67 C +ATOM 7924 C GLY E 178 11.096 87.851 17.501 1.00 39.32 C +ATOM 7925 O GLY E 178 10.242 87.523 18.341 1.00 39.77 O +ATOM 7926 N PRO E 179 10.989 88.978 16.786 1.00 35.29 N +ATOM 7927 CA PRO E 179 9.806 89.827 16.895 1.00 32.60 C +ATOM 7928 C PRO E 179 8.792 89.460 15.818 1.00 31.02 C +ATOM 7929 O PRO E 179 9.165 89.199 14.673 1.00 33.30 O +ATOM 7930 CB PRO E 179 10.388 91.215 16.696 1.00 32.68 C +ATOM 7931 CG PRO E 179 11.441 90.976 15.692 1.00 29.29 C +ATOM 7932 CD PRO E 179 12.092 89.690 16.121 1.00 32.03 C +ATOM 7933 N PHE E 180 7.515 89.447 16.187 1.00 27.99 N +ATOM 7934 CA PHE E 180 6.441 89.106 15.264 1.00 24.92 C +ATOM 7935 C PHE E 180 5.136 89.678 15.777 1.00 26.02 C +ATOM 7936 O PHE E 180 5.060 90.091 16.931 1.00 29.41 O +ATOM 7937 CB PHE E 180 6.315 87.586 15.162 1.00 31.00 C +ATOM 7938 CG PHE E 180 6.233 86.895 16.495 1.00 24.79 C +ATOM 7939 CD1 PHE E 180 7.396 86.538 17.173 1.00 36.18 C +ATOM 7940 CD2 PHE E 180 5.005 86.638 17.087 1.00 16.22 C +ATOM 7941 CE1 PHE E 180 7.338 85.941 18.427 1.00 36.30 C +ATOM 7942 CE2 PHE E 180 4.931 86.049 18.325 1.00 24.20 C +ATOM 7943 CZ PHE E 180 6.100 85.697 19.004 1.00 38.53 C +ATOM 7944 N SER E 181 4.104 89.667 14.936 1.00 26.56 N +ATOM 7945 CA SER E 181 2.787 90.182 15.314 1.00 28.55 C +ATOM 7946 C SER E 181 1.629 89.269 14.925 1.00 27.16 C +ATOM 7947 O SER E 181 1.262 89.178 13.750 1.00 37.10 O +ATOM 7948 CB SER E 181 2.563 91.569 14.718 1.00 35.10 C +ATOM 7949 OG SER E 181 2.517 92.563 15.734 1.00 55.91 O +ATOM 7950 N PRO E 182 1.067 88.545 15.905 1.00 20.55 N +ATOM 7951 CA PRO E 182 -0.052 87.628 15.688 1.00 21.26 C +ATOM 7952 C PRO E 182 -1.241 88.471 15.311 1.00 20.87 C +ATOM 7953 O PRO E 182 -1.222 89.645 15.553 1.00 24.63 O +ATOM 7954 CB PRO E 182 -0.263 87.027 17.068 1.00 15.89 C +ATOM 7955 CG PRO E 182 1.064 87.143 17.708 1.00 21.03 C +ATOM 7956 CD PRO E 182 1.484 88.511 17.311 1.00 15.93 C +ATOM 7957 N ASN E 183 -2.268 87.886 14.715 1.00 20.16 N +ATOM 7958 CA ASN E 183 -3.425 88.670 14.349 1.00 12.89 C +ATOM 7959 C ASN E 183 -4.758 88.030 14.708 1.00 17.98 C +ATOM 7960 O ASN E 183 -5.786 88.326 14.084 1.00 28.20 O +ATOM 7961 CB ASN E 183 -3.366 89.071 12.877 1.00 8.94 C +ATOM 7962 CG ASN E 183 -3.556 87.909 11.926 1.00 13.71 C +ATOM 7963 OD1 ASN E 183 -3.513 86.752 12.314 1.00 17.86 O +ATOM 7964 ND2 ASN E 183 -3.773 88.222 10.654 1.00 19.25 N +ATOM 7965 N VAL E 184 -4.731 87.126 15.691 1.00 14.26 N +ATOM 7966 CA VAL E 184 -5.935 86.458 16.191 1.00 11.97 C +ATOM 7967 C VAL E 184 -5.772 86.401 17.711 1.00 12.82 C +ATOM 7968 O VAL E 184 -6.520 87.050 18.449 1.00 19.04 O +ATOM 7969 CB VAL E 184 -6.125 85.028 15.621 1.00 8.75 C +ATOM 7970 CG1 VAL E 184 -7.372 84.400 16.223 1.00 8.92 C +ATOM 7971 CG2 VAL E 184 -6.260 85.058 14.118 1.00 8.50 C +ATOM 7972 N LEU E 185 -4.768 85.661 18.172 1.00 8.50 N +ATOM 7973 CA LEU E 185 -4.491 85.543 19.596 1.00 8.50 C +ATOM 7974 C LEU E 185 -3.120 86.115 19.760 1.00 10.02 C +ATOM 7975 O LEU E 185 -2.226 85.760 19.023 1.00 16.99 O +ATOM 7976 CB LEU E 185 -4.509 84.087 20.045 1.00 8.50 C +ATOM 7977 CG LEU E 185 -5.661 83.678 20.974 1.00 9.82 C +ATOM 7978 CD1 LEU E 185 -6.987 84.144 20.437 1.00 8.50 C +ATOM 7979 CD2 LEU E 185 -5.685 82.170 21.143 1.00 15.68 C +ATOM 7980 N ASN E 186 -2.959 87.042 20.694 1.00 16.22 N +ATOM 7981 CA ASN E 186 -1.666 87.693 20.931 1.00 14.61 C +ATOM 7982 C ASN E 186 -1.314 87.614 22.418 1.00 16.80 C +ATOM 7983 O ASN E 186 -1.999 88.204 23.249 1.00 19.26 O +ATOM 7984 CB ASN E 186 -1.742 89.162 20.500 1.00 18.22 C +ATOM 7985 CG ASN E 186 -0.398 89.866 20.542 1.00 8.50 C +ATOM 7986 OD1 ASN E 186 0.487 89.519 21.315 1.00 8.50 O +ATOM 7987 ND2 ASN E 186 -0.250 90.869 19.708 1.00 15.50 N +ATOM 7988 N TRP E 187 -0.237 86.903 22.742 1.00 12.27 N +ATOM 7989 CA TRP E 187 0.189 86.741 24.120 1.00 8.50 C +ATOM 7990 C TRP E 187 0.587 88.062 24.774 1.00 11.33 C +ATOM 7991 O TRP E 187 0.616 88.170 25.996 1.00 14.50 O +ATOM 7992 CB TRP E 187 1.345 85.739 24.189 1.00 8.50 C +ATOM 7993 CG TRP E 187 1.612 85.180 25.575 1.00 13.86 C +ATOM 7994 CD1 TRP E 187 2.723 85.387 26.340 1.00 8.50 C +ATOM 7995 CD2 TRP E 187 0.747 84.315 26.349 1.00 14.47 C +ATOM 7996 NE1 TRP E 187 2.601 84.714 27.531 1.00 8.50 N +ATOM 7997 CE2 TRP E 187 1.404 84.050 27.565 1.00 8.50 C +ATOM 7998 CE3 TRP E 187 -0.518 83.744 26.127 1.00 9.90 C +ATOM 7999 CZ2 TRP E 187 0.850 83.246 28.549 1.00 8.50 C +ATOM 8000 CZ3 TRP E 187 -1.062 82.950 27.104 1.00 8.50 C +ATOM 8001 CH2 TRP E 187 -0.380 82.707 28.304 1.00 8.50 C +ATOM 8002 N ARG E 188 0.904 89.060 23.956 1.00 11.53 N +ATOM 8003 CA ARG E 188 1.295 90.384 24.438 1.00 17.54 C +ATOM 8004 C ARG E 188 0.088 91.264 24.768 1.00 24.45 C +ATOM 8005 O ARG E 188 0.198 92.254 25.486 1.00 29.34 O +ATOM 8006 CB ARG E 188 2.100 91.095 23.368 1.00 8.50 C +ATOM 8007 CG ARG E 188 3.583 90.848 23.389 1.00 8.50 C +ATOM 8008 CD ARG E 188 4.194 91.425 22.122 1.00 21.29 C +ATOM 8009 NE ARG E 188 5.584 91.890 22.228 1.00 25.69 N +ATOM 8010 CZ ARG E 188 5.962 93.094 22.677 1.00 34.81 C +ATOM 8011 NH1 ARG E 188 5.072 93.987 23.109 1.00 32.71 N +ATOM 8012 NH2 ARG E 188 7.232 93.467 22.559 1.00 38.09 N +ATOM 8013 N ALA E 189 -1.060 90.905 24.214 1.00 26.30 N +ATOM 8014 CA ALA E 189 -2.303 91.638 24.421 1.00 21.27 C +ATOM 8015 C ALA E 189 -3.388 90.584 24.549 1.00 22.04 C +ATOM 8016 O ALA E 189 -4.346 90.562 23.768 1.00 28.26 O +ATOM 8017 CB ALA E 189 -2.589 92.529 23.221 1.00 20.57 C +ATOM 8018 N LEU E 190 -3.214 89.689 25.517 1.00 18.67 N +ATOM 8019 CA LEU E 190 -4.158 88.601 25.740 1.00 21.04 C +ATOM 8020 C LEU E 190 -5.365 89.075 26.523 1.00 22.33 C +ATOM 8021 O LEU E 190 -5.248 89.908 27.423 1.00 26.77 O +ATOM 8022 CB LEU E 190 -3.478 87.453 26.488 1.00 13.92 C +ATOM 8023 CG LEU E 190 -4.171 86.098 26.413 1.00 11.03 C +ATOM 8024 CD1 LEU E 190 -3.875 85.468 25.070 1.00 18.56 C +ATOM 8025 CD2 LEU E 190 -3.692 85.202 27.514 1.00 8.50 C +ATOM 8026 N LYS E 191 -6.533 88.595 26.129 1.00 27.54 N +ATOM 8027 CA LYS E 191 -7.780 88.943 26.801 1.00 28.98 C +ATOM 8028 C LYS E 191 -8.328 87.585 27.229 1.00 26.09 C +ATOM 8029 O LYS E 191 -8.831 86.811 26.410 1.00 22.70 O +ATOM 8030 CB LYS E 191 -8.732 89.656 25.830 1.00 39.38 C +ATOM 8031 CG LYS E 191 -9.735 90.598 26.492 1.00 58.23 C +ATOM 8032 CD LYS E 191 -10.293 91.606 25.486 1.00 77.83 C +ATOM 8033 CE LYS E 191 -11.240 92.602 26.151 1.00 90.19 C +ATOM 8034 NZ LYS E 191 -11.653 93.702 25.222 1.00 97.74 N +ATOM 8035 N TYR E 192 -8.191 87.280 28.512 1.00 26.28 N +ATOM 8036 CA TYR E 192 -8.618 85.987 29.020 1.00 27.12 C +ATOM 8037 C TYR E 192 -9.475 86.079 30.267 1.00 32.09 C +ATOM 8038 O TYR E 192 -9.705 87.168 30.810 1.00 37.56 O +ATOM 8039 CB TYR E 192 -7.384 85.147 29.333 1.00 20.19 C +ATOM 8040 CG TYR E 192 -6.522 85.760 30.401 1.00 8.50 C +ATOM 8041 CD1 TYR E 192 -5.706 86.857 30.127 1.00 14.11 C +ATOM 8042 CD2 TYR E 192 -6.538 85.260 31.689 1.00 8.50 C +ATOM 8043 CE1 TYR E 192 -4.922 87.441 31.120 1.00 16.24 C +ATOM 8044 CE2 TYR E 192 -5.767 85.826 32.692 1.00 9.88 C +ATOM 8045 CZ TYR E 192 -4.957 86.919 32.405 1.00 20.49 C +ATOM 8046 OH TYR E 192 -4.191 87.486 33.408 1.00 32.27 O +ATOM 8047 N GLU E 193 -9.895 84.909 30.738 1.00 35.16 N +ATOM 8048 CA GLU E 193 -10.721 84.789 31.932 1.00 39.11 C +ATOM 8049 C GLU E 193 -10.316 83.472 32.583 1.00 37.22 C +ATOM 8050 O GLU E 193 -10.358 82.423 31.941 1.00 39.15 O +ATOM 8051 CB GLU E 193 -12.200 84.768 31.540 1.00 51.78 C +ATOM 8052 CG GLU E 193 -13.177 85.052 32.669 1.00 68.13 C +ATOM 8053 CD GLU E 193 -14.622 85.067 32.175 1.00 83.27 C +ATOM 8054 OE1 GLU E 193 -15.233 83.970 32.082 1.00 87.52 O +ATOM 8055 OE2 GLU E 193 -15.135 86.172 31.862 1.00 84.71 O +ATOM 8056 N VAL E 194 -9.851 83.550 33.827 1.00 34.77 N +ATOM 8057 CA VAL E 194 -9.414 82.384 34.585 1.00 32.34 C +ATOM 8058 C VAL E 194 -10.585 81.784 35.360 1.00 35.46 C +ATOM 8059 O VAL E 194 -11.494 82.507 35.780 1.00 41.08 O +ATOM 8060 CB VAL E 194 -8.291 82.776 35.560 1.00 22.84 C +ATOM 8061 CG1 VAL E 194 -7.925 81.619 36.470 1.00 28.78 C +ATOM 8062 CG2 VAL E 194 -7.083 83.205 34.774 1.00 35.71 C +ATOM 8063 N GLN E 195 -10.567 80.468 35.545 1.00 34.56 N +ATOM 8064 CA GLN E 195 -11.626 79.788 36.278 1.00 33.11 C +ATOM 8065 C GLN E 195 -11.042 78.597 37.013 1.00 27.23 C +ATOM 8066 O GLN E 195 -10.444 77.709 36.402 1.00 29.81 O +ATOM 8067 CB GLN E 195 -12.711 79.305 35.314 1.00 45.00 C +ATOM 8068 CG GLN E 195 -14.100 79.250 35.909 1.00 62.88 C +ATOM 8069 CD GLN E 195 -14.636 80.634 36.233 1.00 76.19 C +ATOM 8070 OE1 GLN E 195 -14.885 80.960 37.395 1.00 88.11 O +ATOM 8071 NE2 GLN E 195 -14.805 81.460 35.205 1.00 78.77 N +ATOM 8072 N GLY E 196 -11.168 78.601 38.330 1.00 21.91 N +ATOM 8073 CA GLY E 196 -10.658 77.487 39.100 1.00 27.10 C +ATOM 8074 C GLY E 196 -9.273 77.648 39.681 1.00 27.35 C +ATOM 8075 O GLY E 196 -8.815 78.756 39.936 1.00 32.76 O +ATOM 8076 N GLU E 197 -8.607 76.519 39.872 1.00 25.37 N +ATOM 8077 CA GLU E 197 -7.280 76.480 40.448 1.00 21.73 C +ATOM 8078 C GLU E 197 -6.165 76.718 39.427 1.00 22.16 C +ATOM 8079 O GLU E 197 -5.418 75.795 39.080 1.00 30.30 O +ATOM 8080 CB GLU E 197 -7.086 75.122 41.131 1.00 23.53 C +ATOM 8081 CG GLU E 197 -5.888 75.061 42.070 1.00 35.79 C +ATOM 8082 CD GLU E 197 -6.224 75.468 43.503 1.00 38.04 C +ATOM 8083 OE1 GLU E 197 -7.217 76.203 43.722 1.00 28.13 O +ATOM 8084 OE2 GLU E 197 -5.483 75.037 44.418 1.00 41.89 O +ATOM 8085 N VAL E 198 -6.071 77.939 38.920 1.00 15.42 N +ATOM 8086 CA VAL E 198 -5.024 78.275 37.958 1.00 14.91 C +ATOM 8087 C VAL E 198 -4.386 79.599 38.372 1.00 16.24 C +ATOM 8088 O VAL E 198 -5.087 80.554 38.727 1.00 18.59 O +ATOM 8089 CB VAL E 198 -5.546 78.283 36.462 1.00 15.60 C +ATOM 8090 CG1 VAL E 198 -7.069 78.248 36.405 1.00 9.21 C +ATOM 8091 CG2 VAL E 198 -5.005 79.470 35.684 1.00 8.50 C +ATOM 8092 N PHE E 199 -3.055 79.617 38.384 1.00 13.23 N +ATOM 8093 CA PHE E 199 -2.286 80.793 38.780 1.00 14.81 C +ATOM 8094 C PHE E 199 -1.398 81.300 37.651 1.00 16.06 C +ATOM 8095 O PHE E 199 -1.094 80.568 36.709 1.00 21.06 O +ATOM 8096 CB PHE E 199 -1.383 80.458 39.978 1.00 14.74 C +ATOM 8097 CG PHE E 199 -2.083 79.732 41.091 1.00 18.11 C +ATOM 8098 CD1 PHE E 199 -2.216 78.354 41.053 1.00 19.76 C +ATOM 8099 CD2 PHE E 199 -2.634 80.430 42.166 1.00 28.26 C +ATOM 8100 CE1 PHE E 199 -2.887 77.668 42.062 1.00 20.80 C +ATOM 8101 CE2 PHE E 199 -3.303 79.765 43.177 1.00 22.23 C +ATOM 8102 CZ PHE E 199 -3.429 78.372 43.122 1.00 26.27 C +ATOM 8103 N THR E 200 -0.945 82.543 37.781 1.00 13.77 N +ATOM 8104 CA THR E 200 -0.068 83.152 36.798 1.00 12.27 C +ATOM 8105 C THR E 200 1.295 83.308 37.468 1.00 13.54 C +ATOM 8106 O THR E 200 1.421 84.028 38.455 1.00 22.01 O +ATOM 8107 CB THR E 200 -0.593 84.533 36.380 1.00 12.83 C +ATOM 8108 OG1 THR E 200 -1.927 84.405 35.869 1.00 30.41 O +ATOM 8109 CG2 THR E 200 0.284 85.133 35.312 1.00 13.94 C +ATOM 8110 N LYS E 201 2.295 82.584 36.968 1.00 14.94 N +ATOM 8111 CA LYS E 201 3.658 82.630 37.510 1.00 10.03 C +ATOM 8112 C LYS E 201 4.679 82.838 36.393 1.00 8.50 C +ATOM 8113 O LYS E 201 4.340 82.774 35.217 1.00 8.95 O +ATOM 8114 CB LYS E 201 3.968 81.339 38.279 1.00 14.00 C +ATOM 8115 CG LYS E 201 3.140 81.123 39.569 1.00 17.73 C +ATOM 8116 CD LYS E 201 3.210 82.318 40.502 1.00 22.50 C +ATOM 8117 CE LYS E 201 2.980 81.930 41.949 1.00 22.61 C +ATOM 8118 NZ LYS E 201 4.126 81.118 42.475 1.00 32.93 N +ATOM 8119 N PRO E 202 5.929 83.155 36.744 1.00 8.50 N +ATOM 8120 CA PRO E 202 6.989 83.378 35.765 1.00 8.50 C +ATOM 8121 C PRO E 202 7.274 82.085 35.006 1.00 14.20 C +ATOM 8122 O PRO E 202 7.373 81.033 35.616 1.00 17.37 O +ATOM 8123 CB PRO E 202 8.176 83.746 36.642 1.00 8.50 C +ATOM 8124 CG PRO E 202 7.563 84.329 37.821 1.00 8.50 C +ATOM 8125 CD PRO E 202 6.432 83.409 38.094 1.00 8.50 C +ATOM 8126 N GLN E 203 7.455 82.162 33.692 1.00 12.92 N +ATOM 8127 CA GLN E 203 7.699 80.970 32.893 1.00 8.50 C +ATOM 8128 C GLN E 203 9.018 80.303 33.203 1.00 8.93 C +ATOM 8129 O GLN E 203 10.025 80.986 33.427 1.00 8.50 O +ATOM 8130 CB GLN E 203 7.637 81.310 31.410 1.00 19.70 C +ATOM 8131 CG GLN E 203 8.637 82.346 30.954 1.00 8.50 C +ATOM 8132 CD GLN E 203 8.551 82.572 29.483 1.00 8.50 C +ATOM 8133 OE1 GLN E 203 9.550 82.591 28.802 1.00 11.97 O +ATOM 8134 NE2 GLN E 203 7.338 82.753 28.977 1.00 17.78 N +ATOM 8135 N LEU E 204 9.007 78.965 33.156 1.00 11.43 N +ATOM 8136 CA LEU E 204 10.193 78.149 33.442 1.00 8.50 C +ATOM 8137 C LEU E 204 11.087 77.959 32.247 1.00 11.45 C +ATOM 8138 O LEU E 204 12.286 77.719 32.401 1.00 13.82 O +ATOM 8139 CB LEU E 204 9.803 76.792 34.001 1.00 8.50 C +ATOM 8140 CG LEU E 204 8.848 76.892 35.175 1.00 8.50 C +ATOM 8141 CD1 LEU E 204 7.443 76.701 34.644 1.00 14.82 C +ATOM 8142 CD2 LEU E 204 9.178 75.867 36.208 1.00 8.50 C +ATOM 8143 N TRP E 205 10.486 77.973 31.058 1.00 15.92 N +ATOM 8144 CA TRP E 205 11.250 77.842 29.819 1.00 18.49 C +ATOM 8145 C TRP E 205 11.828 79.208 29.539 1.00 24.05 C +ATOM 8146 O TRP E 205 11.256 80.211 29.955 1.00 35.23 O +ATOM 8147 CB TRP E 205 10.372 77.383 28.654 1.00 14.21 C +ATOM 8148 CG TRP E 205 9.050 78.050 28.574 1.00 11.55 C +ATOM 8149 CD1 TRP E 205 8.768 79.224 27.956 1.00 15.83 C +ATOM 8150 CD2 TRP E 205 7.817 77.575 29.122 1.00 10.89 C +ATOM 8151 NE1 TRP E 205 7.431 79.516 28.084 1.00 20.47 N +ATOM 8152 CE2 TRP E 205 6.824 78.518 28.795 1.00 15.05 C +ATOM 8153 CE3 TRP E 205 7.458 76.449 29.861 1.00 8.50 C +ATOM 8154 CZ2 TRP E 205 5.492 78.369 29.180 1.00 19.03 C +ATOM 8155 CZ3 TRP E 205 6.138 76.302 30.248 1.00 14.39 C +ATOM 8156 CH2 TRP E 205 5.169 77.256 29.907 1.00 17.17 C +ATOM 8157 N PRO E 206 13.008 79.262 28.912 1.00 28.91 N +ATOM 8158 CA PRO E 206 13.665 80.530 28.593 1.00 30.49 C +ATOM 8159 C PRO E 206 13.076 81.220 27.356 1.00 35.67 C +ATOM 8160 O PRO E 206 13.127 82.474 27.326 1.00 40.21 O +ATOM 8161 CB PRO E 206 15.110 80.098 28.388 1.00 28.64 C +ATOM 8162 CG PRO E 206 14.948 78.757 27.738 1.00 30.61 C +ATOM 8163 CD PRO E 206 13.885 78.122 28.584 1.00 34.22 C +ATOM 8164 OXT PRO E 206 12.554 80.512 26.451 1.00 34.32 O +TER 8165 PRO E 206 +ATOM 8166 N GLN F 1 -1.134 74.999 171.323 1.00 61.89 N +ATOM 8167 CA GLN F 1 -0.098 76.048 171.157 1.00 54.71 C +ATOM 8168 C GLN F 1 1.091 75.639 172.036 1.00 53.67 C +ATOM 8169 O GLN F 1 1.438 76.312 173.006 1.00 62.14 O +ATOM 8170 CB GLN F 1 -0.682 77.413 171.541 1.00 60.45 C +ATOM 8171 CG GLN F 1 -0.308 78.556 170.597 1.00 73.93 C +ATOM 8172 CD GLN F 1 -0.973 79.878 170.982 1.00 84.46 C +ATOM 8173 OE1 GLN F 1 -1.831 79.918 171.865 1.00 82.81 O +ATOM 8174 NE2 GLN F 1 -0.586 80.962 170.311 1.00 85.66 N +ATOM 8175 N THR F 2 1.692 74.505 171.705 1.00 42.06 N +ATOM 8176 CA THR F 2 2.808 74.016 172.478 1.00 34.62 C +ATOM 8177 C THR F 2 4.005 73.910 171.567 1.00 33.29 C +ATOM 8178 O THR F 2 3.860 73.541 170.401 1.00 39.28 O +ATOM 8179 CB THR F 2 2.488 72.634 173.049 1.00 36.41 C +ATOM 8180 OG1 THR F 2 1.191 72.657 173.665 1.00 39.74 O +ATOM 8181 CG2 THR F 2 3.537 72.227 174.079 1.00 48.53 C +ATOM 8182 N ASP F 3 5.172 74.291 172.068 1.00 28.88 N +ATOM 8183 CA ASP F 3 6.388 74.193 171.268 1.00 23.39 C +ATOM 8184 C ASP F 3 6.895 72.770 171.445 1.00 27.26 C +ATOM 8185 O ASP F 3 7.543 72.435 172.453 1.00 28.04 O +ATOM 8186 CB ASP F 3 7.443 75.185 171.749 1.00 30.19 C +ATOM 8187 CG ASP F 3 8.524 75.417 170.725 1.00 36.99 C +ATOM 8188 OD1 ASP F 3 8.595 74.623 169.760 1.00 34.76 O +ATOM 8189 OD2 ASP F 3 9.284 76.406 170.868 1.00 50.09 O +ATOM 8190 N MET F 4 6.571 71.924 170.474 1.00 23.66 N +ATOM 8191 CA MET F 4 6.960 70.522 170.524 1.00 16.76 C +ATOM 8192 C MET F 4 8.390 70.261 170.089 1.00 15.36 C +ATOM 8193 O MET F 4 8.762 69.113 169.865 1.00 12.77 O +ATOM 8194 CB MET F 4 5.994 69.685 169.702 1.00 11.93 C +ATOM 8195 CG MET F 4 4.606 69.550 170.312 1.00 9.95 C +ATOM 8196 SD MET F 4 4.694 68.775 171.934 1.00 32.79 S +ATOM 8197 CE MET F 4 4.933 67.062 171.533 1.00 9.96 C +ATOM 8198 N SER F 5 9.190 71.326 170.009 1.00 13.06 N +ATOM 8199 CA SER F 5 10.588 71.240 169.599 1.00 12.53 C +ATOM 8200 C SER F 5 11.388 70.261 170.424 1.00 14.92 C +ATOM 8201 O SER F 5 11.307 70.261 171.649 1.00 22.20 O +ATOM 8202 CB SER F 5 11.278 72.614 169.673 1.00 14.52 C +ATOM 8203 OG SER F 5 10.891 73.448 168.596 1.00 30.23 O +ATOM 8204 N ARG F 6 12.177 69.444 169.730 1.00 15.14 N +ATOM 8205 CA ARG F 6 13.037 68.444 170.343 1.00 14.47 C +ATOM 8206 C ARG F 6 12.273 67.336 171.070 1.00 15.71 C +ATOM 8207 O ARG F 6 12.849 66.550 171.819 1.00 21.11 O +ATOM 8208 CB ARG F 6 14.044 69.113 171.264 1.00 32.11 C +ATOM 8209 CG ARG F 6 15.417 68.503 171.201 1.00 40.60 C +ATOM 8210 CD ARG F 6 16.374 69.295 170.314 1.00 39.59 C +ATOM 8211 NE ARG F 6 17.738 69.036 170.766 1.00 47.83 N +ATOM 8212 CZ ARG F 6 18.240 69.496 171.911 1.00 44.52 C +ATOM 8213 NH1 ARG F 6 17.499 70.262 172.704 1.00 35.44 N +ATOM 8214 NH2 ARG F 6 19.435 69.095 172.326 1.00 39.43 N +ATOM 8215 N LYS F 7 10.977 67.242 170.806 1.00 16.32 N +ATOM 8216 CA LYS F 7 10.143 66.220 171.418 1.00 11.73 C +ATOM 8217 C LYS F 7 9.498 65.316 170.373 1.00 12.88 C +ATOM 8218 O LYS F 7 9.479 65.624 169.176 1.00 12.42 O +ATOM 8219 CB LYS F 7 9.081 66.869 172.299 1.00 17.85 C +ATOM 8220 CG LYS F 7 9.660 67.472 173.570 1.00 25.30 C +ATOM 8221 CD LYS F 7 8.731 68.505 174.191 1.00 34.35 C +ATOM 8222 CE LYS F 7 9.361 69.153 175.408 1.00 38.40 C +ATOM 8223 NZ LYS F 7 8.529 70.294 175.856 1.00 59.12 N +ATOM 8224 N ALA F 8 9.012 64.171 170.834 1.00 14.74 N +ATOM 8225 CA ALA F 8 8.373 63.188 169.976 1.00 10.23 C +ATOM 8226 C ALA F 8 7.299 62.482 170.782 1.00 8.50 C +ATOM 8227 O ALA F 8 7.406 62.377 171.997 1.00 8.50 O +ATOM 8228 CB ALA F 8 9.418 62.179 169.508 1.00 16.75 C +ATOM 8229 N PHE F 9 6.227 62.076 170.118 1.00 11.20 N +ATOM 8230 CA PHE F 9 5.157 61.327 170.776 1.00 9.81 C +ATOM 8231 C PHE F 9 5.619 59.883 170.672 1.00 10.71 C +ATOM 8232 O PHE F 9 6.097 59.459 169.613 1.00 9.17 O +ATOM 8233 CB PHE F 9 3.833 61.452 170.025 1.00 9.42 C +ATOM 8234 CG PHE F 9 3.224 62.822 170.074 1.00 11.06 C +ATOM 8235 CD1 PHE F 9 2.829 63.375 171.285 1.00 9.67 C +ATOM 8236 CD2 PHE F 9 2.988 63.541 168.896 1.00 15.81 C +ATOM 8237 CE1 PHE F 9 2.197 64.627 171.330 1.00 13.29 C +ATOM 8238 CE2 PHE F 9 2.358 64.790 168.929 1.00 14.80 C +ATOM 8239 CZ PHE F 9 1.961 65.332 170.146 1.00 11.44 C +ATOM 8240 N VAL F 10 5.499 59.133 171.759 1.00 9.70 N +ATOM 8241 CA VAL F 10 5.917 57.734 171.754 1.00 11.96 C +ATOM 8242 C VAL F 10 4.816 56.756 172.203 1.00 10.64 C +ATOM 8243 O VAL F 10 4.257 56.889 173.290 1.00 9.70 O +ATOM 8244 CB VAL F 10 7.260 57.532 172.531 1.00 9.89 C +ATOM 8245 CG1 VAL F 10 7.405 58.541 173.644 1.00 8.70 C +ATOM 8246 CG2 VAL F 10 7.363 56.115 173.069 1.00 8.50 C +ATOM 8247 N PHE F 11 4.455 55.848 171.295 1.00 11.45 N +ATOM 8248 CA PHE F 11 3.428 54.813 171.506 1.00 12.74 C +ATOM 8249 C PHE F 11 4.208 53.525 171.801 1.00 14.64 C +ATOM 8250 O PHE F 11 4.579 52.798 170.872 1.00 15.69 O +ATOM 8251 CB PHE F 11 2.605 54.621 170.217 1.00 14.45 C +ATOM 8252 CG PHE F 11 2.023 55.896 169.669 1.00 21.05 C +ATOM 8253 CD1 PHE F 11 0.773 56.363 170.109 1.00 27.11 C +ATOM 8254 CD2 PHE F 11 2.720 56.644 168.727 1.00 15.77 C +ATOM 8255 CE1 PHE F 11 0.220 57.567 169.619 1.00 12.73 C +ATOM 8256 CE2 PHE F 11 2.182 57.843 168.236 1.00 21.05 C +ATOM 8257 CZ PHE F 11 0.925 58.301 168.689 1.00 15.43 C +ATOM 8258 N PRO F 12 4.443 53.214 173.095 1.00 14.43 N +ATOM 8259 CA PRO F 12 5.191 52.040 173.564 1.00 14.13 C +ATOM 8260 C PRO F 12 4.632 50.666 173.257 1.00 23.09 C +ATOM 8261 O PRO F 12 5.400 49.696 173.154 1.00 31.50 O +ATOM 8262 CB PRO F 12 5.283 52.259 175.076 1.00 10.83 C +ATOM 8263 CG PRO F 12 5.077 53.726 175.244 1.00 20.51 C +ATOM 8264 CD PRO F 12 3.980 53.998 174.248 1.00 22.15 C +ATOM 8265 N LYS F 13 3.312 50.541 173.177 1.00 28.93 N +ATOM 8266 CA LYS F 13 2.739 49.228 172.889 1.00 34.35 C +ATOM 8267 C LYS F 13 1.555 49.215 171.943 1.00 34.85 C +ATOM 8268 O LYS F 13 0.872 50.232 171.759 1.00 34.82 O +ATOM 8269 CB LYS F 13 2.420 48.446 174.180 1.00 42.59 C +ATOM 8270 CG LYS F 13 1.708 49.216 175.298 1.00 49.31 C +ATOM 8271 CD LYS F 13 1.658 48.361 176.566 1.00 58.15 C +ATOM 8272 CE LYS F 13 1.113 49.121 177.773 1.00 64.79 C +ATOM 8273 NZ LYS F 13 -0.323 49.524 177.633 1.00 67.01 N +ATOM 8274 N GLU F 14 1.335 48.047 171.339 1.00 36.09 N +ATOM 8275 CA GLU F 14 0.253 47.848 170.381 1.00 43.70 C +ATOM 8276 C GLU F 14 -1.090 48.114 171.038 1.00 45.19 C +ATOM 8277 O GLU F 14 -1.461 47.470 172.026 1.00 45.63 O +ATOM 8278 CB GLU F 14 0.289 46.432 169.783 1.00 46.09 C +ATOM 8279 CG GLU F 14 -0.683 46.243 168.604 1.00 48.75 C +ATOM 8280 CD GLU F 14 -0.548 44.883 167.921 1.00 55.97 C +ATOM 8281 OE1 GLU F 14 0.537 44.588 167.353 1.00 55.17 O +ATOM 8282 OE2 GLU F 14 -1.541 44.118 167.939 1.00 54.28 O +ATOM 8283 N SER F 15 -1.806 49.090 170.496 1.00 47.62 N +ATOM 8284 CA SER F 15 -3.093 49.456 171.045 1.00 45.19 C +ATOM 8285 C SER F 15 -4.204 49.571 170.009 1.00 44.50 C +ATOM 8286 O SER F 15 -4.002 49.450 168.793 1.00 40.24 O +ATOM 8287 CB SER F 15 -2.972 50.750 171.873 1.00 47.49 C +ATOM 8288 OG SER F 15 -2.329 51.793 171.155 1.00 47.75 O +ATOM 8289 N ASP F 16 -5.395 49.765 170.543 1.00 46.56 N +ATOM 8290 CA ASP F 16 -6.620 49.895 169.786 1.00 45.46 C +ATOM 8291 C ASP F 16 -7.150 51.277 170.182 1.00 41.86 C +ATOM 8292 O ASP F 16 -7.965 51.874 169.484 1.00 41.51 O +ATOM 8293 CB ASP F 16 -7.575 48.807 170.309 1.00 59.50 C +ATOM 8294 CG ASP F 16 -8.656 48.414 169.319 1.00 69.70 C +ATOM 8295 OD1 ASP F 16 -8.456 48.591 168.099 1.00 73.86 O +ATOM 8296 OD2 ASP F 16 -9.701 47.888 169.773 1.00 70.48 O +ATOM 8297 N THR F 17 -6.601 51.800 171.274 1.00 38.36 N +ATOM 8298 CA THR F 17 -7.021 53.061 171.866 1.00 40.64 C +ATOM 8299 C THR F 17 -6.078 54.288 171.844 1.00 43.48 C +ATOM 8300 O THR F 17 -6.535 55.435 172.038 1.00 44.79 O +ATOM 8301 CB THR F 17 -7.390 52.802 173.341 1.00 46.51 C +ATOM 8302 OG1 THR F 17 -6.329 52.067 173.976 1.00 48.28 O +ATOM 8303 CG2 THR F 17 -8.670 52.001 173.434 1.00 51.56 C +ATOM 8304 N SER F 18 -4.777 54.062 171.666 1.00 37.92 N +ATOM 8305 CA SER F 18 -3.815 55.172 171.668 1.00 26.34 C +ATOM 8306 C SER F 18 -3.703 55.923 170.338 1.00 22.47 C +ATOM 8307 O SER F 18 -3.629 55.311 169.261 1.00 20.21 O +ATOM 8308 CB SER F 18 -2.433 54.669 172.095 1.00 33.80 C +ATOM 8309 OG SER F 18 -2.498 53.981 173.346 1.00 36.26 O +ATOM 8310 N TYR F 19 -3.705 57.250 170.431 1.00 17.91 N +ATOM 8311 CA TYR F 19 -3.594 58.138 169.277 1.00 15.14 C +ATOM 8312 C TYR F 19 -3.505 59.594 169.726 1.00 14.16 C +ATOM 8313 O TYR F 19 -3.796 59.926 170.877 1.00 12.02 O +ATOM 8314 CB TYR F 19 -4.780 57.965 168.323 1.00 18.25 C +ATOM 8315 CG TYR F 19 -6.107 58.474 168.837 1.00 25.89 C +ATOM 8316 CD1 TYR F 19 -6.480 59.810 168.653 1.00 30.73 C +ATOM 8317 CD2 TYR F 19 -7.006 57.618 169.472 1.00 26.22 C +ATOM 8318 CE1 TYR F 19 -7.718 60.279 169.084 1.00 36.67 C +ATOM 8319 CE2 TYR F 19 -8.250 58.077 169.907 1.00 34.25 C +ATOM 8320 CZ TYR F 19 -8.599 59.407 169.708 1.00 35.79 C +ATOM 8321 OH TYR F 19 -9.822 59.879 170.121 1.00 41.50 O +ATOM 8322 N VAL F 20 -3.075 60.455 168.811 1.00 17.30 N +ATOM 8323 CA VAL F 20 -2.939 61.881 169.082 1.00 12.58 C +ATOM 8324 C VAL F 20 -3.673 62.603 167.970 1.00 15.63 C +ATOM 8325 O VAL F 20 -3.433 62.343 166.788 1.00 16.13 O +ATOM 8326 CB VAL F 20 -1.465 62.341 169.063 1.00 8.50 C +ATOM 8327 CG1 VAL F 20 -1.394 63.838 169.266 1.00 15.66 C +ATOM 8328 CG2 VAL F 20 -0.680 61.644 170.136 1.00 8.50 C +ATOM 8329 N SER F 21 -4.606 63.463 168.355 1.00 18.82 N +ATOM 8330 CA SER F 21 -5.389 64.225 167.403 1.00 20.00 C +ATOM 8331 C SER F 21 -4.750 65.598 167.209 1.00 17.03 C +ATOM 8332 O SER F 21 -4.418 66.283 168.181 1.00 18.81 O +ATOM 8333 CB SER F 21 -6.828 64.373 167.915 1.00 28.50 C +ATOM 8334 OG SER F 21 -7.635 65.088 166.993 1.00 46.69 O +ATOM 8335 N LEU F 22 -4.561 65.978 165.953 1.00 12.28 N +ATOM 8336 CA LEU F 22 -3.972 67.260 165.611 1.00 13.04 C +ATOM 8337 C LEU F 22 -5.075 68.175 165.100 1.00 22.72 C +ATOM 8338 O LEU F 22 -5.879 67.784 164.231 1.00 25.56 O +ATOM 8339 CB LEU F 22 -2.894 67.071 164.545 1.00 14.96 C +ATOM 8340 CG LEU F 22 -1.423 66.958 164.986 1.00 17.02 C +ATOM 8341 CD1 LEU F 22 -1.244 66.149 166.269 1.00 10.56 C +ATOM 8342 CD2 LEU F 22 -0.626 66.352 163.851 1.00 13.46 C +ATOM 8343 N LYS F 23 -5.124 69.385 165.659 1.00 30.13 N +ATOM 8344 CA LYS F 23 -6.136 70.381 165.290 1.00 34.38 C +ATOM 8345 C LYS F 23 -5.551 71.426 164.346 1.00 34.81 C +ATOM 8346 O LYS F 23 -4.653 72.184 164.711 1.00 33.87 O +ATOM 8347 CB LYS F 23 -6.731 71.085 166.541 1.00 56.05 C +ATOM 8348 CG LYS F 23 -7.180 70.184 167.753 1.00 75.55 C +ATOM 8349 CD LYS F 23 -8.529 69.420 167.575 1.00 83.06 C +ATOM 8350 CE LYS F 23 -8.885 68.579 168.837 1.00 77.73 C +ATOM 8351 NZ LYS F 23 -10.067 67.654 168.693 1.00 60.65 N +ATOM 8352 N ALA F 24 -6.058 71.443 163.121 1.00 44.89 N +ATOM 8353 CA ALA F 24 -5.605 72.392 162.115 1.00 54.75 C +ATOM 8354 C ALA F 24 -6.719 73.392 161.869 1.00 66.98 C +ATOM 8355 O ALA F 24 -7.885 73.001 161.701 1.00 72.80 O +ATOM 8356 CB ALA F 24 -5.275 71.673 160.828 1.00 55.46 C +ATOM 8357 N PRO F 25 -6.391 74.699 161.898 1.00 74.69 N +ATOM 8358 CA PRO F 25 -7.379 75.764 161.671 1.00 79.48 C +ATOM 8359 C PRO F 25 -7.543 76.037 160.176 1.00 79.90 C +ATOM 8360 O PRO F 25 -7.195 77.107 159.671 1.00 79.30 O +ATOM 8361 CB PRO F 25 -6.766 76.953 162.412 1.00 85.39 C +ATOM 8362 CG PRO F 25 -5.295 76.752 162.177 1.00 81.11 C +ATOM 8363 CD PRO F 25 -5.107 75.255 162.368 1.00 76.06 C +ATOM 8364 N LEU F 26 -8.081 75.047 159.477 1.00 81.63 N +ATOM 8365 CA LEU F 26 -8.278 75.140 158.045 1.00 82.27 C +ATOM 8366 C LEU F 26 -9.632 75.748 157.684 1.00 85.62 C +ATOM 8367 O LEU F 26 -10.662 75.439 158.303 1.00 84.72 O +ATOM 8368 CB LEU F 26 -8.114 73.757 157.425 1.00 82.35 C +ATOM 8369 CG LEU F 26 -7.228 73.638 156.182 1.00 78.04 C +ATOM 8370 CD1 LEU F 26 -6.021 74.569 156.268 1.00 74.09 C +ATOM 8371 CD2 LEU F 26 -6.797 72.184 156.038 1.00 69.84 C +ATOM 8372 N THR F 27 -9.604 76.641 156.695 1.00 88.58 N +ATOM 8373 CA THR F 27 -10.797 77.340 156.215 1.00 88.01 C +ATOM 8374 C THR F 27 -11.047 77.037 154.742 1.00 82.11 C +ATOM 8375 O THR F 27 -12.175 76.747 154.337 1.00 82.78 O +ATOM 8376 CB THR F 27 -10.650 78.877 156.392 1.00 91.91 C +ATOM 8377 OG1 THR F 27 -9.382 79.305 155.870 1.00 91.31 O +ATOM 8378 CG2 THR F 27 -10.747 79.267 157.871 1.00 97.21 C +ATOM 8379 N LYS F 28 -9.991 77.150 153.944 1.00 76.22 N +ATOM 8380 CA LYS F 28 -10.056 76.884 152.509 1.00 71.02 C +ATOM 8381 C LYS F 28 -9.700 75.422 152.245 1.00 62.46 C +ATOM 8382 O LYS F 28 -8.878 74.839 152.961 1.00 66.80 O +ATOM 8383 CB LYS F 28 -9.057 77.779 151.756 1.00 77.83 C +ATOM 8384 CG LYS F 28 -9.494 79.227 151.545 1.00 90.20 C +ATOM 8385 CD LYS F 28 -10.523 79.345 150.424 1.00 97.85 C +ATOM 8386 CE LYS F 28 -10.907 80.794 150.163 1.00 99.26 C +ATOM 8387 NZ LYS F 28 -11.850 80.912 149.016 1.00102.96 N +ATOM 8388 N PRO F 29 -10.384 74.781 151.281 1.00 51.28 N +ATOM 8389 CA PRO F 29 -10.092 73.382 150.955 1.00 44.86 C +ATOM 8390 C PRO F 29 -8.736 73.312 150.209 1.00 40.12 C +ATOM 8391 O PRO F 29 -8.378 74.237 149.467 1.00 39.26 O +ATOM 8392 CB PRO F 29 -11.285 72.991 150.085 1.00 42.14 C +ATOM 8393 CG PRO F 29 -11.668 74.274 149.435 1.00 48.80 C +ATOM 8394 CD PRO F 29 -11.594 75.241 150.578 1.00 49.78 C +ATOM 8395 N LEU F 30 -7.981 72.234 150.425 1.00 32.35 N +ATOM 8396 CA LEU F 30 -6.661 72.081 149.810 1.00 23.68 C +ATOM 8397 C LEU F 30 -6.626 71.700 148.325 1.00 20.39 C +ATOM 8398 O LEU F 30 -7.292 70.750 147.888 1.00 12.38 O +ATOM 8399 CB LEU F 30 -5.806 71.086 150.598 1.00 21.84 C +ATOM 8400 CG LEU F 30 -5.334 71.361 152.024 1.00 11.86 C +ATOM 8401 CD1 LEU F 30 -5.412 72.827 152.348 1.00 8.50 C +ATOM 8402 CD2 LEU F 30 -6.163 70.540 152.998 1.00 23.41 C +ATOM 8403 N LYS F 31 -5.804 72.437 147.579 1.00 17.86 N +ATOM 8404 CA LYS F 31 -5.600 72.237 146.141 1.00 16.99 C +ATOM 8405 C LYS F 31 -4.181 71.722 145.901 1.00 17.11 C +ATOM 8406 O LYS F 31 -3.763 71.491 144.756 1.00 12.55 O +ATOM 8407 CB LYS F 31 -5.795 73.556 145.388 1.00 26.51 C +ATOM 8408 CG LYS F 31 -7.246 73.953 145.144 1.00 44.76 C +ATOM 8409 CD LYS F 31 -7.908 72.985 144.159 1.00 62.06 C +ATOM 8410 CE LYS F 31 -9.391 73.285 143.948 1.00 71.78 C +ATOM 8411 NZ LYS F 31 -10.016 72.315 143.002 1.00 78.32 N +ATOM 8412 N ALA F 32 -3.443 71.594 147.002 1.00 17.81 N +ATOM 8413 CA ALA F 32 -2.066 71.110 147.028 1.00 12.25 C +ATOM 8414 C ALA F 32 -1.665 71.053 148.499 1.00 11.05 C +ATOM 8415 O ALA F 32 -2.372 71.591 149.347 1.00 15.54 O +ATOM 8416 CB ALA F 32 -1.161 72.059 146.280 1.00 15.13 C +ATOM 8417 N PHE F 33 -0.565 70.380 148.812 1.00 11.40 N +ATOM 8418 CA PHE F 33 -0.092 70.287 150.199 1.00 12.73 C +ATOM 8419 C PHE F 33 1.255 69.567 150.266 1.00 16.03 C +ATOM 8420 O PHE F 33 1.659 68.892 149.304 1.00 17.39 O +ATOM 8421 CB PHE F 33 -1.115 69.563 151.097 1.00 8.50 C +ATOM 8422 CG PHE F 33 -1.349 68.115 150.727 1.00 10.96 C +ATOM 8423 CD1 PHE F 33 -0.561 67.103 151.274 1.00 8.50 C +ATOM 8424 CD2 PHE F 33 -2.379 67.758 149.855 1.00 18.18 C +ATOM 8425 CE1 PHE F 33 -0.798 65.760 150.962 1.00 8.50 C +ATOM 8426 CE2 PHE F 33 -2.620 66.406 149.538 1.00 16.26 C +ATOM 8427 CZ PHE F 33 -1.829 65.412 150.092 1.00 9.91 C +ATOM 8428 N THR F 34 1.960 69.756 151.379 1.00 12.61 N +ATOM 8429 CA THR F 34 3.244 69.105 151.619 1.00 10.03 C +ATOM 8430 C THR F 34 3.199 68.758 153.081 1.00 10.64 C +ATOM 8431 O THR F 34 2.858 69.608 153.900 1.00 11.98 O +ATOM 8432 CB THR F 34 4.448 70.055 151.440 1.00 8.50 C +ATOM 8433 OG1 THR F 34 4.439 70.619 150.126 1.00 8.50 O +ATOM 8434 CG2 THR F 34 5.749 69.302 151.648 1.00 8.50 C +ATOM 8435 N VAL F 35 3.459 67.503 153.410 1.00 11.26 N +ATOM 8436 CA VAL F 35 3.478 67.083 154.811 1.00 12.13 C +ATOM 8437 C VAL F 35 4.770 66.315 155.043 1.00 12.67 C +ATOM 8438 O VAL F 35 5.121 65.418 154.268 1.00 14.31 O +ATOM 8439 CB VAL F 35 2.209 66.269 155.228 1.00 8.50 C +ATOM 8440 CG1 VAL F 35 1.514 65.709 154.014 1.00 15.34 C +ATOM 8441 CG2 VAL F 35 2.564 65.185 156.195 1.00 8.50 C +ATOM 8442 N CYS F 36 5.529 66.761 156.038 1.00 11.89 N +ATOM 8443 CA CYS F 36 6.805 66.153 156.386 1.00 10.38 C +ATOM 8444 C CYS F 36 6.710 65.676 157.816 1.00 9.31 C +ATOM 8445 O CYS F 36 5.962 66.246 158.596 1.00 13.11 O +ATOM 8446 CB CYS F 36 7.934 67.179 156.265 1.00 8.50 C +ATOM 8447 SG CYS F 36 8.154 67.870 154.580 1.00 15.42 S +ATOM 8448 N LEU F 37 7.426 64.606 158.141 1.00 9.16 N +ATOM 8449 CA LEU F 37 7.426 64.058 159.494 1.00 9.57 C +ATOM 8450 C LEU F 37 8.594 63.100 159.704 1.00 10.12 C +ATOM 8451 O LEU F 37 9.256 62.675 158.753 1.00 11.23 O +ATOM 8452 CB LEU F 37 6.086 63.369 159.802 1.00 16.65 C +ATOM 8453 CG LEU F 37 5.598 62.184 158.960 1.00 11.31 C +ATOM 8454 CD1 LEU F 37 6.130 60.891 159.553 1.00 8.56 C +ATOM 8455 CD2 LEU F 37 4.092 62.161 158.941 1.00 8.50 C +ATOM 8456 N HIS F 38 8.857 62.785 160.959 1.00 9.71 N +ATOM 8457 CA HIS F 38 9.951 61.894 161.344 1.00 13.26 C +ATOM 8458 C HIS F 38 9.297 60.755 162.125 1.00 13.84 C +ATOM 8459 O HIS F 38 8.469 61.012 162.994 1.00 21.04 O +ATOM 8460 CB HIS F 38 10.872 62.645 162.303 1.00 12.92 C +ATOM 8461 CG HIS F 38 12.278 62.796 161.828 1.00 14.64 C +ATOM 8462 ND1 HIS F 38 12.869 64.031 161.648 1.00 8.50 N +ATOM 8463 CD2 HIS F 38 13.244 61.874 161.594 1.00 17.36 C +ATOM 8464 CE1 HIS F 38 14.142 63.861 161.328 1.00 16.59 C +ATOM 8465 NE2 HIS F 38 14.396 62.563 161.289 1.00 15.88 N +ATOM 8466 N PHE F 39 9.624 59.510 161.818 1.00 8.97 N +ATOM 8467 CA PHE F 39 9.041 58.409 162.561 1.00 8.50 C +ATOM 8468 C PHE F 39 10.106 57.368 162.755 1.00 8.50 C +ATOM 8469 O PHE F 39 11.105 57.359 162.051 1.00 13.53 O +ATOM 8470 CB PHE F 39 7.781 57.837 161.884 1.00 8.50 C +ATOM 8471 CG PHE F 39 8.047 57.035 160.644 1.00 8.50 C +ATOM 8472 CD1 PHE F 39 8.162 57.650 159.409 1.00 13.37 C +ATOM 8473 CD2 PHE F 39 8.154 55.662 160.710 1.00 8.50 C +ATOM 8474 CE1 PHE F 39 8.379 56.908 158.258 1.00 16.58 C +ATOM 8475 CE2 PHE F 39 8.368 54.909 159.569 1.00 16.49 C +ATOM 8476 CZ PHE F 39 8.482 55.536 158.335 1.00 17.80 C +ATOM 8477 N TYR F 40 9.924 56.518 163.743 1.00 8.50 N +ATOM 8478 CA TYR F 40 10.902 55.487 164.031 1.00 10.57 C +ATOM 8479 C TYR F 40 10.198 54.271 164.641 1.00 12.08 C +ATOM 8480 O TYR F 40 9.778 54.317 165.800 1.00 13.99 O +ATOM 8481 CB TYR F 40 11.935 56.052 165.002 1.00 8.50 C +ATOM 8482 CG TYR F 40 13.023 55.076 165.379 1.00 8.99 C +ATOM 8483 CD1 TYR F 40 13.371 54.028 164.532 1.00 8.50 C +ATOM 8484 CD2 TYR F 40 13.722 55.217 166.575 1.00 13.72 C +ATOM 8485 CE1 TYR F 40 14.379 53.155 164.855 1.00 8.50 C +ATOM 8486 CE2 TYR F 40 14.746 54.338 166.913 1.00 15.15 C +ATOM 8487 CZ TYR F 40 15.067 53.308 166.044 1.00 9.61 C +ATOM 8488 OH TYR F 40 16.081 52.430 166.347 1.00 8.50 O +ATOM 8489 N THR F 41 10.085 53.191 163.874 1.00 9.68 N +ATOM 8490 CA THR F 41 9.406 51.997 164.349 1.00 11.87 C +ATOM 8491 C THR F 41 10.115 50.710 163.935 1.00 17.88 C +ATOM 8492 O THR F 41 10.962 50.718 163.042 1.00 20.01 O +ATOM 8493 CB THR F 41 7.945 51.948 163.849 1.00 11.75 C +ATOM 8494 OG1 THR F 41 7.293 50.805 164.416 1.00 20.93 O +ATOM 8495 CG2 THR F 41 7.895 51.832 162.324 1.00 13.12 C +ATOM 8496 N GLU F 42 9.718 49.598 164.547 1.00 19.76 N +ATOM 8497 CA GLU F 42 10.329 48.307 164.258 1.00 26.04 C +ATOM 8498 C GLU F 42 9.335 47.341 163.588 1.00 26.85 C +ATOM 8499 O GLU F 42 9.603 46.151 163.437 1.00 31.85 O +ATOM 8500 CB GLU F 42 10.831 47.712 165.576 1.00 37.30 C +ATOM 8501 CG GLU F 42 12.162 46.964 165.503 1.00 46.08 C +ATOM 8502 CD GLU F 42 12.771 46.724 166.885 1.00 53.39 C +ATOM 8503 OE1 GLU F 42 12.437 45.705 167.537 1.00 50.40 O +ATOM 8504 OE2 GLU F 42 13.580 47.574 167.325 1.00 56.15 O +ATOM 8505 N LEU F 43 8.124 47.828 163.328 1.00 23.98 N +ATOM 8506 CA LEU F 43 7.054 47.029 162.709 1.00 14.58 C +ATOM 8507 C LEU F 43 7.286 46.669 161.262 1.00 14.13 C +ATOM 8508 O LEU F 43 6.850 45.628 160.824 1.00 15.43 O +ATOM 8509 CB LEU F 43 5.726 47.777 162.763 1.00 23.62 C +ATOM 8510 CG LEU F 43 4.787 47.719 163.967 1.00 30.17 C +ATOM 8511 CD1 LEU F 43 5.553 47.461 165.281 1.00 30.23 C +ATOM 8512 CD2 LEU F 43 3.983 49.031 163.997 1.00 8.50 C +ATOM 8513 N SER F 44 7.924 47.566 160.519 1.00 23.67 N +ATOM 8514 CA SER F 44 8.225 47.392 159.095 1.00 28.52 C +ATOM 8515 C SER F 44 8.418 45.939 158.587 1.00 34.71 C +ATOM 8516 O SER F 44 7.995 45.598 157.464 1.00 33.99 O +ATOM 8517 CB SER F 44 9.481 48.216 158.740 1.00 29.82 C +ATOM 8518 OG SER F 44 9.441 49.511 159.308 1.00 29.62 O +ATOM 8519 N SER F 45 9.048 45.105 159.419 1.00 38.15 N +ATOM 8520 CA SER F 45 9.360 43.718 159.087 1.00 44.04 C +ATOM 8521 C SER F 45 8.260 42.691 159.352 1.00 43.46 C +ATOM 8522 O SER F 45 8.375 41.545 158.894 1.00 52.15 O +ATOM 8523 CB SER F 45 10.635 43.282 159.830 1.00 51.40 C +ATOM 8524 OG SER F 45 11.676 44.238 159.695 1.00 61.73 O +ATOM 8525 N THR F 46 7.222 43.067 160.102 1.00 34.64 N +ATOM 8526 CA THR F 46 6.139 42.125 160.421 1.00 28.72 C +ATOM 8527 C THR F 46 4.722 42.534 159.976 1.00 31.10 C +ATOM 8528 O THR F 46 3.992 41.698 159.425 1.00 42.29 O +ATOM 8529 CB THR F 46 6.113 41.770 161.914 1.00 25.31 C +ATOM 8530 OG1 THR F 46 5.399 42.788 162.631 1.00 40.55 O +ATOM 8531 CG2 THR F 46 7.540 41.673 162.472 1.00 26.47 C +ATOM 8532 N ARG F 47 4.304 43.779 160.224 1.00 20.82 N +ATOM 8533 CA ARG F 47 2.969 44.200 159.788 1.00 19.46 C +ATOM 8534 C ARG F 47 2.944 45.582 159.154 1.00 18.77 C +ATOM 8535 O ARG F 47 3.977 46.227 159.031 1.00 24.59 O +ATOM 8536 CB ARG F 47 1.958 44.134 160.935 1.00 13.76 C +ATOM 8537 CG ARG F 47 2.150 45.142 162.044 1.00 10.25 C +ATOM 8538 CD ARG F 47 1.026 44.994 163.044 1.00 11.00 C +ATOM 8539 NE ARG F 47 1.164 45.868 164.203 1.00 16.43 N +ATOM 8540 CZ ARG F 47 0.669 47.105 164.261 1.00 25.49 C +ATOM 8541 NH1 ARG F 47 0.022 47.607 163.216 1.00 29.37 N +ATOM 8542 NH2 ARG F 47 0.757 47.821 165.383 1.00 24.08 N +ATOM 8543 N GLY F 48 1.770 46.003 158.689 1.00 22.33 N +ATOM 8544 CA GLY F 48 1.626 47.331 158.099 1.00 19.10 C +ATOM 8545 C GLY F 48 1.199 48.279 159.211 1.00 20.04 C +ATOM 8546 O GLY F 48 0.777 47.818 160.280 1.00 28.35 O +ATOM 8547 N TYR F 49 1.290 49.584 158.987 1.00 16.51 N +ATOM 8548 CA TYR F 49 0.902 50.550 160.024 1.00 17.62 C +ATOM 8549 C TYR F 49 0.614 51.929 159.437 1.00 20.36 C +ATOM 8550 O TYR F 49 1.115 52.273 158.352 1.00 27.76 O +ATOM 8551 CB TYR F 49 1.998 50.656 161.084 1.00 13.84 C +ATOM 8552 CG TYR F 49 3.378 50.878 160.515 1.00 20.43 C +ATOM 8553 CD1 TYR F 49 3.788 52.145 160.089 1.00 27.19 C +ATOM 8554 CD2 TYR F 49 4.288 49.822 160.417 1.00 17.15 C +ATOM 8555 CE1 TYR F 49 5.084 52.349 159.571 1.00 30.20 C +ATOM 8556 CE2 TYR F 49 5.584 50.018 159.909 1.00 16.22 C +ATOM 8557 CZ TYR F 49 5.972 51.275 159.487 1.00 17.42 C +ATOM 8558 OH TYR F 49 7.227 51.457 158.960 1.00 8.50 O +ATOM 8559 N SER F 50 -0.182 52.717 160.148 1.00 15.27 N +ATOM 8560 CA SER F 50 -0.538 54.045 159.683 1.00 20.63 C +ATOM 8561 C SER F 50 0.414 55.099 160.226 1.00 26.83 C +ATOM 8562 O SER F 50 0.661 55.171 161.437 1.00 36.45 O +ATOM 8563 CB SER F 50 -1.968 54.389 160.093 1.00 26.41 C +ATOM 8564 OG SER F 50 -2.315 55.721 159.734 1.00 33.61 O +ATOM 8565 N ILE F 51 0.935 55.925 159.323 1.00 23.58 N +ATOM 8566 CA ILE F 51 1.847 56.995 159.691 1.00 15.44 C +ATOM 8567 C ILE F 51 1.105 58.314 159.892 1.00 15.22 C +ATOM 8568 O ILE F 51 1.189 58.916 160.951 1.00 19.56 O +ATOM 8569 CB ILE F 51 2.943 57.152 158.626 1.00 10.51 C +ATOM 8570 CG1 ILE F 51 3.748 55.852 158.523 1.00 16.94 C +ATOM 8571 CG2 ILE F 51 3.868 58.293 158.987 1.00 12.16 C +ATOM 8572 CD1 ILE F 51 4.786 55.849 157.448 1.00 8.50 C +ATOM 8573 N PHE F 52 0.328 58.718 158.893 1.00 12.88 N +ATOM 8574 CA PHE F 52 -0.429 59.969 158.929 1.00 10.79 C +ATOM 8575 C PHE F 52 -1.825 59.719 158.333 1.00 15.56 C +ATOM 8576 O PHE F 52 -1.930 59.254 157.189 1.00 14.10 O +ATOM 8577 CB PHE F 52 0.317 61.012 158.088 1.00 15.10 C +ATOM 8578 CG PHE F 52 -0.245 62.405 158.179 1.00 17.93 C +ATOM 8579 CD1 PHE F 52 -0.049 63.171 159.330 1.00 21.95 C +ATOM 8580 CD2 PHE F 52 -0.936 62.967 157.105 1.00 8.50 C +ATOM 8581 CE1 PHE F 52 -0.532 64.477 159.408 1.00 15.31 C +ATOM 8582 CE2 PHE F 52 -1.420 64.261 157.172 1.00 8.50 C +ATOM 8583 CZ PHE F 52 -1.220 65.023 158.322 1.00 15.25 C +ATOM 8584 N SER F 53 -2.880 60.029 159.096 1.00 17.90 N +ATOM 8585 CA SER F 53 -4.264 59.827 158.653 1.00 13.97 C +ATOM 8586 C SER F 53 -5.117 61.097 158.697 1.00 11.74 C +ATOM 8587 O SER F 53 -5.504 61.555 159.769 1.00 12.29 O +ATOM 8588 CB SER F 53 -4.935 58.754 159.508 1.00 21.46 C +ATOM 8589 OG SER F 53 -6.187 58.367 158.954 1.00 37.23 O +ATOM 8590 N TYR F 54 -5.414 61.649 157.525 1.00 11.62 N +ATOM 8591 CA TYR F 54 -6.214 62.870 157.383 1.00 15.62 C +ATOM 8592 C TYR F 54 -7.568 62.443 156.840 1.00 24.63 C +ATOM 8593 O TYR F 54 -7.683 62.055 155.669 1.00 25.38 O +ATOM 8594 CB TYR F 54 -5.529 63.811 156.387 1.00 19.21 C +ATOM 8595 CG TYR F 54 -6.147 65.187 156.211 1.00 19.12 C +ATOM 8596 CD1 TYR F 54 -7.190 65.394 155.306 1.00 18.29 C +ATOM 8597 CD2 TYR F 54 -5.627 66.295 156.875 1.00 11.18 C +ATOM 8598 CE1 TYR F 54 -7.688 66.674 155.056 1.00 13.76 C +ATOM 8599 CE2 TYR F 54 -6.123 67.567 156.637 1.00 13.74 C +ATOM 8600 CZ TYR F 54 -7.146 67.749 155.725 1.00 13.38 C +ATOM 8601 OH TYR F 54 -7.614 69.006 155.467 1.00 8.50 O +ATOM 8602 N ALA F 55 -8.594 62.534 157.680 1.00 32.17 N +ATOM 8603 CA ALA F 55 -9.935 62.108 157.288 1.00 34.99 C +ATOM 8604 C ALA F 55 -11.009 63.190 157.282 1.00 34.59 C +ATOM 8605 O ALA F 55 -10.976 64.112 158.092 1.00 36.51 O +ATOM 8606 CB ALA F 55 -10.376 60.956 158.186 1.00 36.61 C +ATOM 8607 N THR F 56 -11.986 63.020 156.400 1.00 36.34 N +ATOM 8608 CA THR F 56 -13.123 63.922 156.261 1.00 41.14 C +ATOM 8609 C THR F 56 -14.389 63.108 156.559 1.00 46.11 C +ATOM 8610 O THR F 56 -14.355 61.868 156.577 1.00 44.59 O +ATOM 8611 CB THR F 56 -13.282 64.430 154.818 1.00 42.97 C +ATOM 8612 OG1 THR F 56 -11.997 64.716 154.253 1.00 47.65 O +ATOM 8613 CG2 THR F 56 -14.165 65.696 154.791 1.00 52.67 C +ATOM 8614 N LYS F 57 -15.506 63.807 156.769 1.00 50.58 N +ATOM 8615 CA LYS F 57 -16.789 63.155 157.035 1.00 51.36 C +ATOM 8616 C LYS F 57 -17.174 62.317 155.817 1.00 51.01 C +ATOM 8617 O LYS F 57 -17.597 61.164 155.941 1.00 54.19 O +ATOM 8618 CB LYS F 57 -17.882 64.204 157.305 1.00 57.92 C +ATOM 8619 CG LYS F 57 -17.675 64.992 158.600 1.00 66.99 C +ATOM 8620 CD LYS F 57 -18.648 66.156 158.766 1.00 64.73 C +ATOM 8621 CE LYS F 57 -18.331 66.939 160.045 1.00 63.27 C +ATOM 8622 NZ LYS F 57 -19.179 68.165 160.224 1.00 53.10 N +ATOM 8623 N ARG F 58 -16.959 62.901 154.640 1.00 50.08 N +ATOM 8624 CA ARG F 58 -17.267 62.280 153.344 1.00 48.94 C +ATOM 8625 C ARG F 58 -16.276 61.177 152.927 1.00 44.79 C +ATOM 8626 O ARG F 58 -16.663 60.143 152.371 1.00 41.91 O +ATOM 8627 CB ARG F 58 -17.283 63.392 152.276 1.00 56.12 C +ATOM 8628 CG ARG F 58 -17.742 63.002 150.855 1.00 77.03 C +ATOM 8629 CD ARG F 58 -16.593 62.939 149.799 1.00 83.91 C +ATOM 8630 NE ARG F 58 -15.802 64.174 149.657 1.00 88.76 N +ATOM 8631 CZ ARG F 58 -15.822 64.987 148.596 1.00 81.06 C +ATOM 8632 NH1 ARG F 58 -16.603 64.721 147.549 1.00 69.95 N +ATOM 8633 NH2 ARG F 58 -15.042 66.069 148.578 1.00 71.96 N +ATOM 8634 N GLN F 59 -14.996 61.409 153.195 1.00 41.21 N +ATOM 8635 CA GLN F 59 -13.952 60.468 152.818 1.00 33.51 C +ATOM 8636 C GLN F 59 -13.025 60.220 153.999 1.00 30.56 C +ATOM 8637 O GLN F 59 -12.316 61.123 154.425 1.00 37.61 O +ATOM 8638 CB GLN F 59 -13.178 61.061 151.632 1.00 36.38 C +ATOM 8639 CG GLN F 59 -11.903 60.330 151.244 1.00 31.83 C +ATOM 8640 CD GLN F 59 -12.149 58.893 150.861 1.00 30.05 C +ATOM 8641 OE1 GLN F 59 -12.179 58.008 151.717 1.00 36.27 O +ATOM 8642 NE2 GLN F 59 -12.298 58.646 149.571 1.00 27.91 N +ATOM 8643 N ASP F 60 -13.023 58.996 154.509 1.00 27.84 N +ATOM 8644 CA ASP F 60 -12.191 58.636 155.658 1.00 31.28 C +ATOM 8645 C ASP F 60 -10.685 58.625 155.366 1.00 27.01 C +ATOM 8646 O ASP F 60 -9.859 58.812 156.272 1.00 28.66 O +ATOM 8647 CB ASP F 60 -12.626 57.282 156.241 1.00 45.76 C +ATOM 8648 CG ASP F 60 -12.461 56.127 155.249 1.00 47.60 C +ATOM 8649 OD1 ASP F 60 -12.985 56.227 154.113 1.00 53.40 O +ATOM 8650 OD2 ASP F 60 -11.816 55.114 155.613 1.00 38.99 O +ATOM 8651 N ASN F 61 -10.321 58.397 154.113 1.00 19.57 N +ATOM 8652 CA ASN F 61 -8.910 58.388 153.747 1.00 13.51 C +ATOM 8653 C ASN F 61 -8.632 59.501 152.750 1.00 13.11 C +ATOM 8654 O ASN F 61 -8.275 59.231 151.600 1.00 13.36 O +ATOM 8655 CB ASN F 61 -8.528 57.038 153.160 1.00 15.98 C +ATOM 8656 CG ASN F 61 -8.602 55.923 154.178 1.00 34.37 C +ATOM 8657 OD1 ASN F 61 -8.780 54.760 153.812 1.00 43.74 O +ATOM 8658 ND2 ASN F 61 -8.463 56.263 155.465 1.00 34.89 N +ATOM 8659 N GLU F 62 -8.821 60.747 153.191 1.00 11.56 N +ATOM 8660 CA GLU F 62 -8.618 61.922 152.338 1.00 11.57 C +ATOM 8661 C GLU F 62 -7.155 62.035 151.915 1.00 14.58 C +ATOM 8662 O GLU F 62 -6.852 62.352 150.766 1.00 18.73 O +ATOM 8663 CB GLU F 62 -9.095 63.195 153.037 1.00 11.29 C +ATOM 8664 CG GLU F 62 -9.259 64.406 152.127 1.00 8.50 C +ATOM 8665 CD GLU F 62 -10.387 64.251 151.140 1.00 19.48 C +ATOM 8666 OE1 GLU F 62 -10.347 63.282 150.365 1.00 31.84 O +ATOM 8667 OE2 GLU F 62 -11.313 65.093 151.115 1.00 26.54 O +ATOM 8668 N ILE F 63 -6.255 61.848 152.869 1.00 15.39 N +ATOM 8669 CA ILE F 63 -4.822 61.842 152.603 1.00 12.28 C +ATOM 8670 C ILE F 63 -4.281 60.920 153.695 1.00 9.36 C +ATOM 8671 O ILE F 63 -4.587 61.103 154.873 1.00 9.39 O +ATOM 8672 CB ILE F 63 -4.154 63.303 152.555 1.00 18.59 C +ATOM 8673 CG1 ILE F 63 -2.855 63.347 153.351 1.00 22.19 C +ATOM 8674 CG2 ILE F 63 -5.096 64.421 152.957 1.00 8.50 C +ATOM 8675 CD1 ILE F 63 -1.712 62.631 152.667 1.00 29.76 C +ATOM 8676 N LEU F 64 -3.589 59.864 153.288 1.00 8.50 N +ATOM 8677 CA LEU F 64 -3.054 58.892 154.228 1.00 8.50 C +ATOM 8678 C LEU F 64 -1.712 58.327 153.798 1.00 13.24 C +ATOM 8679 O LEU F 64 -1.534 57.936 152.636 1.00 16.28 O +ATOM 8680 CB LEU F 64 -4.066 57.762 154.403 1.00 11.25 C +ATOM 8681 CG LEU F 64 -3.634 56.473 155.095 1.00 15.53 C +ATOM 8682 CD1 LEU F 64 -4.369 56.311 156.400 1.00 18.72 C +ATOM 8683 CD2 LEU F 64 -3.930 55.295 154.197 1.00 12.29 C +ATOM 8684 N ILE F 65 -0.767 58.317 154.734 1.00 10.10 N +ATOM 8685 CA ILE F 65 0.577 57.776 154.500 1.00 11.88 C +ATOM 8686 C ILE F 65 0.646 56.481 155.303 1.00 15.23 C +ATOM 8687 O ILE F 65 0.464 56.491 156.526 1.00 13.91 O +ATOM 8688 CB ILE F 65 1.655 58.742 154.971 1.00 12.51 C +ATOM 8689 CG1 ILE F 65 1.511 60.059 154.211 1.00 8.90 C +ATOM 8690 CG2 ILE F 65 3.038 58.130 154.782 1.00 8.50 C +ATOM 8691 CD1 ILE F 65 2.327 61.166 154.788 1.00 11.52 C +ATOM 8692 N PHE F 66 0.954 55.381 154.626 1.00 15.03 N +ATOM 8693 CA PHE F 66 0.955 54.072 155.264 1.00 13.87 C +ATOM 8694 C PHE F 66 2.106 53.208 154.796 1.00 10.97 C +ATOM 8695 O PHE F 66 2.566 53.333 153.664 1.00 10.12 O +ATOM 8696 CB PHE F 66 -0.359 53.397 154.854 1.00 28.32 C +ATOM 8697 CG PHE F 66 -0.691 52.146 155.612 1.00 39.54 C +ATOM 8698 CD1 PHE F 66 -0.259 50.900 155.154 1.00 44.86 C +ATOM 8699 CD2 PHE F 66 -1.489 52.206 156.753 1.00 38.69 C +ATOM 8700 CE1 PHE F 66 -0.614 49.732 155.816 1.00 46.06 C +ATOM 8701 CE2 PHE F 66 -1.850 51.050 157.422 1.00 43.31 C +ATOM 8702 CZ PHE F 66 -1.410 49.804 156.952 1.00 50.46 C +ATOM 8703 N TRP F 67 2.564 52.314 155.659 1.00 8.98 N +ATOM 8704 CA TRP F 67 3.627 51.386 155.270 1.00 19.52 C +ATOM 8705 C TRP F 67 2.977 50.006 155.129 1.00 26.00 C +ATOM 8706 O TRP F 67 2.510 49.433 156.127 1.00 31.59 O +ATOM 8707 CB TRP F 67 4.731 51.308 156.325 1.00 15.88 C +ATOM 8708 CG TRP F 67 5.659 50.138 156.114 1.00 26.41 C +ATOM 8709 CD1 TRP F 67 5.556 48.883 156.678 1.00 33.56 C +ATOM 8710 CD2 TRP F 67 6.812 50.096 155.264 1.00 31.22 C +ATOM 8711 NE1 TRP F 67 6.573 48.068 156.227 1.00 28.97 N +ATOM 8712 CE2 TRP F 67 7.358 48.786 155.359 1.00 36.62 C +ATOM 8713 CE3 TRP F 67 7.440 51.030 154.431 1.00 15.05 C +ATOM 8714 CZ2 TRP F 67 8.501 48.403 154.649 1.00 32.14 C +ATOM 8715 CZ3 TRP F 67 8.570 50.645 153.730 1.00 15.75 C +ATOM 8716 CH2 TRP F 67 9.092 49.343 153.842 1.00 21.91 C +ATOM 8717 N SER F 68 2.893 49.489 153.907 1.00 21.05 N +ATOM 8718 CA SER F 68 2.292 48.184 153.724 1.00 17.16 C +ATOM 8719 C SER F 68 3.383 47.141 153.629 1.00 20.84 C +ATOM 8720 O SER F 68 4.234 47.170 152.728 1.00 15.80 O +ATOM 8721 CB SER F 68 1.363 48.145 152.516 1.00 19.47 C +ATOM 8722 OG SER F 68 2.068 48.266 151.300 1.00 28.13 O +ATOM 8723 N LYS F 69 3.377 46.267 154.632 1.00 27.30 N +ATOM 8724 CA LYS F 69 4.337 45.181 154.801 1.00 29.25 C +ATOM 8725 C LYS F 69 4.751 44.538 153.474 1.00 26.24 C +ATOM 8726 O LYS F 69 3.905 44.293 152.622 1.00 31.09 O +ATOM 8727 CB LYS F 69 3.717 44.146 155.751 1.00 30.66 C +ATOM 8728 CG LYS F 69 4.700 43.262 156.530 1.00 45.26 C +ATOM 8729 CD LYS F 69 5.345 42.157 155.670 1.00 59.27 C +ATOM 8730 CE LYS F 69 5.856 40.966 156.502 1.00 50.65 C +ATOM 8731 NZ LYS F 69 4.720 40.132 157.011 1.00 58.23 N +ATOM 8732 N ASP F 70 6.057 44.332 153.291 1.00 31.56 N +ATOM 8733 CA ASP F 70 6.601 43.710 152.085 1.00 40.00 C +ATOM 8734 C ASP F 70 6.486 44.496 150.778 1.00 43.10 C +ATOM 8735 O ASP F 70 6.877 43.991 149.718 1.00 51.60 O +ATOM 8736 CB ASP F 70 5.984 42.321 151.877 1.00 46.75 C +ATOM 8737 CG ASP F 70 6.610 41.264 152.751 1.00 53.75 C +ATOM 8738 OD1 ASP F 70 7.679 41.521 153.347 1.00 65.75 O +ATOM 8739 OD2 ASP F 70 6.027 40.164 152.835 1.00 60.18 O +ATOM 8740 N ILE F 71 5.942 45.705 150.825 1.00 39.59 N +ATOM 8741 CA ILE F 71 5.813 46.489 149.605 1.00 36.15 C +ATOM 8742 C ILE F 71 6.587 47.802 149.685 1.00 30.40 C +ATOM 8743 O ILE F 71 7.572 47.989 148.956 1.00 30.74 O +ATOM 8744 CB ILE F 71 4.321 46.749 149.240 1.00 39.37 C +ATOM 8745 CG1 ILE F 71 3.603 45.412 148.993 1.00 39.73 C +ATOM 8746 CG2 ILE F 71 4.224 47.639 147.996 1.00 27.87 C +ATOM 8747 CD1 ILE F 71 2.133 45.560 148.628 1.00 53.44 C +ATOM 8748 N GLY F 72 6.154 48.689 150.584 1.00 24.36 N +ATOM 8749 CA GLY F 72 6.800 49.983 150.740 1.00 17.03 C +ATOM 8750 C GLY F 72 5.823 51.036 151.221 1.00 14.84 C +ATOM 8751 O GLY F 72 4.864 50.735 151.937 1.00 17.91 O +ATOM 8752 N TYR F 73 6.066 52.280 150.838 1.00 11.64 N +ATOM 8753 CA TYR F 73 5.194 53.370 151.250 1.00 10.85 C +ATOM 8754 C TYR F 73 3.961 53.424 150.374 1.00 12.13 C +ATOM 8755 O TYR F 73 4.040 53.364 149.143 1.00 13.82 O +ATOM 8756 CB TYR F 73 5.935 54.708 151.216 1.00 8.50 C +ATOM 8757 CG TYR F 73 7.015 54.783 152.230 1.00 8.50 C +ATOM 8758 CD1 TYR F 73 6.709 54.991 153.561 1.00 8.50 C +ATOM 8759 CD2 TYR F 73 8.339 54.569 151.875 1.00 8.50 C +ATOM 8760 CE1 TYR F 73 7.703 54.980 154.534 1.00 12.38 C +ATOM 8761 CE2 TYR F 73 9.348 54.553 152.833 1.00 11.09 C +ATOM 8762 CZ TYR F 73 9.023 54.758 154.164 1.00 17.57 C +ATOM 8763 OH TYR F 73 10.017 54.756 155.121 1.00 22.57 O +ATOM 8764 N SER F 74 2.822 53.542 151.028 1.00 11.57 N +ATOM 8765 CA SER F 74 1.545 53.615 150.357 1.00 11.35 C +ATOM 8766 C SER F 74 0.972 55.006 150.599 1.00 12.15 C +ATOM 8767 O SER F 74 0.508 55.329 151.709 1.00 11.62 O +ATOM 8768 CB SER F 74 0.613 52.560 150.940 1.00 20.02 C +ATOM 8769 OG SER F 74 -0.720 52.707 150.479 1.00 29.25 O +ATOM 8770 N PHE F 75 1.040 55.840 149.571 1.00 12.41 N +ATOM 8771 CA PHE F 75 0.519 57.198 149.669 1.00 13.25 C +ATOM 8772 C PHE F 75 -0.842 57.266 148.996 1.00 9.56 C +ATOM 8773 O PHE F 75 -0.960 57.041 147.796 1.00 8.50 O +ATOM 8774 CB PHE F 75 1.487 58.199 149.026 1.00 14.90 C +ATOM 8775 CG PHE F 75 0.999 59.613 149.068 1.00 13.02 C +ATOM 8776 CD1 PHE F 75 0.871 60.283 150.282 1.00 10.24 C +ATOM 8777 CD2 PHE F 75 0.640 60.269 147.898 1.00 14.49 C +ATOM 8778 CE1 PHE F 75 0.389 61.586 150.328 1.00 15.71 C +ATOM 8779 CE2 PHE F 75 0.153 61.585 147.938 1.00 22.63 C +ATOM 8780 CZ PHE F 75 0.025 62.243 149.152 1.00 14.00 C +ATOM 8781 N THR F 76 -1.866 57.578 149.775 1.00 11.66 N +ATOM 8782 CA THR F 76 -3.217 57.662 149.235 1.00 18.21 C +ATOM 8783 C THR F 76 -3.915 59.015 149.514 1.00 15.84 C +ATOM 8784 O THR F 76 -3.918 59.524 150.646 1.00 10.85 O +ATOM 8785 CB THR F 76 -4.093 56.429 149.705 1.00 20.62 C +ATOM 8786 OG1 THR F 76 -5.442 56.836 150.001 1.00 28.44 O +ATOM 8787 CG2 THR F 76 -3.488 55.773 150.917 1.00 18.30 C +ATOM 8788 N VAL F 77 -4.445 59.623 148.457 1.00 11.51 N +ATOM 8789 CA VAL F 77 -5.149 60.886 148.599 1.00 18.61 C +ATOM 8790 C VAL F 77 -6.484 60.771 147.875 1.00 23.17 C +ATOM 8791 O VAL F 77 -6.538 60.360 146.714 1.00 28.77 O +ATOM 8792 CB VAL F 77 -4.314 62.115 148.086 1.00 21.48 C +ATOM 8793 CG1 VAL F 77 -3.443 61.721 146.920 1.00 25.58 C +ATOM 8794 CG2 VAL F 77 -5.245 63.274 147.670 1.00 14.91 C +ATOM 8795 N GLY F 78 -7.563 61.051 148.599 1.00 22.20 N +ATOM 8796 CA GLY F 78 -8.895 60.977 148.034 1.00 19.09 C +ATOM 8797 C GLY F 78 -9.335 59.542 147.792 1.00 24.20 C +ATOM 8798 O GLY F 78 -10.009 59.245 146.792 1.00 32.79 O +ATOM 8799 N GLY F 79 -8.944 58.641 148.691 1.00 22.63 N +ATOM 8800 CA GLY F 79 -9.324 57.243 148.550 1.00 19.14 C +ATOM 8801 C GLY F 79 -8.550 56.459 147.514 1.00 16.78 C +ATOM 8802 O GLY F 79 -8.652 55.236 147.494 1.00 17.85 O +ATOM 8803 N SER F 80 -7.803 57.147 146.651 1.00 18.82 N +ATOM 8804 CA SER F 80 -6.991 56.493 145.619 1.00 22.28 C +ATOM 8805 C SER F 80 -5.527 56.345 146.073 1.00 23.14 C +ATOM 8806 O SER F 80 -4.861 57.319 146.452 1.00 27.02 O +ATOM 8807 CB SER F 80 -7.084 57.254 144.293 1.00 25.59 C +ATOM 8808 OG SER F 80 -8.395 57.186 143.755 1.00 37.25 O +ATOM 8809 N GLU F 81 -5.050 55.106 146.032 1.00 19.47 N +ATOM 8810 CA GLU F 81 -3.714 54.737 146.470 1.00 16.25 C +ATOM 8811 C GLU F 81 -2.656 54.740 145.358 1.00 17.18 C +ATOM 8812 O GLU F 81 -2.974 54.679 144.166 1.00 16.69 O +ATOM 8813 CB GLU F 81 -3.811 53.354 147.113 1.00 17.15 C +ATOM 8814 CG GLU F 81 -2.526 52.764 147.633 1.00 26.35 C +ATOM 8815 CD GLU F 81 -2.668 51.290 147.952 1.00 36.50 C +ATOM 8816 OE1 GLU F 81 -2.974 50.501 147.024 1.00 46.57 O +ATOM 8817 OE2 GLU F 81 -2.472 50.921 149.127 1.00 41.45 O +ATOM 8818 N ILE F 82 -1.397 54.825 145.775 1.00 18.00 N +ATOM 8819 CA ILE F 82 -0.248 54.823 144.880 1.00 11.75 C +ATOM 8820 C ILE F 82 0.908 54.242 145.702 1.00 11.07 C +ATOM 8821 O ILE F 82 0.957 54.403 146.930 1.00 10.89 O +ATOM 8822 CB ILE F 82 0.058 56.250 144.368 1.00 9.73 C +ATOM 8823 CG1 ILE F 82 0.771 56.174 143.038 1.00 19.83 C +ATOM 8824 CG2 ILE F 82 0.936 57.018 145.323 1.00 8.50 C +ATOM 8825 CD1 ILE F 82 0.780 57.501 142.323 1.00 25.09 C +ATOM 8826 N LEU F 83 1.835 53.564 145.046 1.00 8.50 N +ATOM 8827 CA LEU F 83 2.905 52.925 145.788 1.00 8.72 C +ATOM 8828 C LEU F 83 4.312 53.355 145.499 1.00 13.72 C +ATOM 8829 O LEU F 83 4.675 53.617 144.359 1.00 18.56 O +ATOM 8830 CB LEU F 83 2.816 51.413 145.614 1.00 12.15 C +ATOM 8831 CG LEU F 83 2.092 50.574 146.668 1.00 18.80 C +ATOM 8832 CD1 LEU F 83 0.783 51.178 147.099 1.00 16.47 C +ATOM 8833 CD2 LEU F 83 1.856 49.202 146.099 1.00 27.95 C +ATOM 8834 N PHE F 84 5.113 53.388 146.554 1.00 14.13 N +ATOM 8835 CA PHE F 84 6.513 53.738 146.459 1.00 12.55 C +ATOM 8836 C PHE F 84 7.219 52.567 147.080 1.00 12.94 C +ATOM 8837 O PHE F 84 7.294 52.413 148.298 1.00 11.38 O +ATOM 8838 CB PHE F 84 6.799 55.038 147.185 1.00 11.92 C +ATOM 8839 CG PHE F 84 6.296 56.228 146.462 1.00 8.50 C +ATOM 8840 CD1 PHE F 84 6.830 56.561 145.239 1.00 8.50 C +ATOM 8841 CD2 PHE F 84 5.251 56.968 146.963 1.00 8.50 C +ATOM 8842 CE1 PHE F 84 6.322 57.611 144.514 1.00 17.58 C +ATOM 8843 CE2 PHE F 84 4.730 58.030 146.247 1.00 17.80 C +ATOM 8844 CZ PHE F 84 5.261 58.355 145.018 1.00 14.89 C +ATOM 8845 N GLU F 85 7.625 51.675 146.197 1.00 15.60 N +ATOM 8846 CA GLU F 85 8.281 50.453 146.582 1.00 23.72 C +ATOM 8847 C GLU F 85 9.617 50.641 147.280 1.00 25.51 C +ATOM 8848 O GLU F 85 10.452 51.442 146.850 1.00 27.32 O +ATOM 8849 CB GLU F 85 8.425 49.555 145.356 1.00 35.71 C +ATOM 8850 CG GLU F 85 7.119 49.403 144.583 1.00 59.90 C +ATOM 8851 CD GLU F 85 7.014 48.072 143.855 1.00 76.15 C +ATOM 8852 OE1 GLU F 85 7.531 47.962 142.718 1.00 79.70 O +ATOM 8853 OE2 GLU F 85 6.410 47.133 144.426 1.00 86.40 O +ATOM 8854 N VAL F 86 9.784 49.913 148.380 1.00 29.02 N +ATOM 8855 CA VAL F 86 11.001 49.925 149.174 1.00 38.22 C +ATOM 8856 C VAL F 86 11.317 48.454 149.493 1.00 49.61 C +ATOM 8857 O VAL F 86 10.737 47.864 150.417 1.00 54.38 O +ATOM 8858 CB VAL F 86 10.813 50.731 150.485 1.00 38.94 C +ATOM 8859 CG1 VAL F 86 12.040 50.588 151.392 1.00 40.62 C +ATOM 8860 CG2 VAL F 86 10.579 52.192 150.165 1.00 43.24 C +ATOM 8861 N PRO F 87 12.240 47.846 148.720 1.00 55.12 N +ATOM 8862 CA PRO F 87 12.677 46.449 148.857 1.00 63.84 C +ATOM 8863 C PRO F 87 13.403 46.089 150.157 1.00 71.63 C +ATOM 8864 O PRO F 87 12.931 45.246 150.930 1.00 76.22 O +ATOM 8865 CB PRO F 87 13.593 46.264 147.643 1.00 63.82 C +ATOM 8866 CG PRO F 87 14.197 47.623 147.471 1.00 54.00 C +ATOM 8867 CD PRO F 87 12.995 48.522 147.647 1.00 53.56 C +ATOM 8868 N GLU F 88 14.573 46.693 150.360 1.00 75.05 N +ATOM 8869 CA GLU F 88 15.385 46.446 151.542 1.00 76.00 C +ATOM 8870 C GLU F 88 14.966 47.433 152.628 1.00 70.15 C +ATOM 8871 O GLU F 88 15.196 48.633 152.507 1.00 65.17 O +ATOM 8872 CB GLU F 88 16.869 46.628 151.198 1.00 85.90 C +ATOM 8873 CG GLU F 88 17.850 46.090 152.241 1.00 96.24 C +ATOM 8874 CD GLU F 88 19.293 46.514 151.975 1.00102.13 C +ATOM 8875 OE1 GLU F 88 19.721 46.492 150.800 1.00107.20 O +ATOM 8876 OE2 GLU F 88 20.004 46.871 152.942 1.00103.55 O +ATOM 8877 N VAL F 89 14.291 46.931 153.654 1.00 68.85 N +ATOM 8878 CA VAL F 89 13.848 47.777 154.749 1.00 67.20 C +ATOM 8879 C VAL F 89 14.921 47.801 155.829 1.00 63.86 C +ATOM 8880 O VAL F 89 15.496 46.766 156.174 1.00 59.82 O +ATOM 8881 CB VAL F 89 12.488 47.311 155.340 1.00 72.86 C +ATOM 8882 CG1 VAL F 89 12.632 45.980 156.077 1.00 75.64 C +ATOM 8883 CG2 VAL F 89 11.927 48.388 156.260 1.00 78.78 C +ATOM 8884 N THR F 90 15.213 48.997 156.327 1.00 64.71 N +ATOM 8885 CA THR F 90 16.224 49.173 157.357 1.00 61.14 C +ATOM 8886 C THR F 90 15.584 49.786 158.591 1.00 55.10 C +ATOM 8887 O THR F 90 14.606 50.535 158.492 1.00 60.70 O +ATOM 8888 CB THR F 90 17.403 50.066 156.860 1.00 66.36 C +ATOM 8889 OG1 THR F 90 18.480 50.008 157.802 1.00 72.57 O +ATOM 8890 CG2 THR F 90 16.966 51.526 156.680 1.00 66.39 C +ATOM 8891 N VAL F 91 16.119 49.431 159.751 1.00 45.22 N +ATOM 8892 CA VAL F 91 15.616 49.938 161.015 1.00 39.44 C +ATOM 8893 C VAL F 91 16.475 51.121 161.501 1.00 36.97 C +ATOM 8894 O VAL F 91 17.662 50.970 161.841 1.00 39.97 O +ATOM 8895 CB VAL F 91 15.564 48.812 162.053 1.00 39.41 C +ATOM 8896 CG1 VAL F 91 16.938 48.142 162.195 1.00 39.30 C +ATOM 8897 CG2 VAL F 91 15.055 49.349 163.379 1.00 53.13 C +ATOM 8898 N ALA F 92 15.880 52.309 161.456 1.00 24.94 N +ATOM 8899 CA ALA F 92 16.540 53.547 161.867 1.00 17.10 C +ATOM 8900 C ALA F 92 15.492 54.629 161.732 1.00 13.52 C +ATOM 8901 O ALA F 92 14.475 54.419 161.062 1.00 21.04 O +ATOM 8902 CB ALA F 92 17.716 53.856 160.959 1.00 22.96 C +ATOM 8903 N PRO F 93 15.669 55.764 162.427 1.00 9.54 N +ATOM 8904 CA PRO F 93 14.625 56.770 162.253 1.00 9.99 C +ATOM 8905 C PRO F 93 14.618 57.149 160.784 1.00 10.17 C +ATOM 8906 O PRO F 93 15.656 57.078 160.109 1.00 19.30 O +ATOM 8907 CB PRO F 93 15.112 57.922 163.138 1.00 12.05 C +ATOM 8908 CG PRO F 93 15.830 57.225 164.227 1.00 9.90 C +ATOM 8909 CD PRO F 93 16.631 56.179 163.460 1.00 8.50 C +ATOM 8910 N VAL F 94 13.449 57.495 160.278 1.00 8.50 N +ATOM 8911 CA VAL F 94 13.332 57.882 158.891 1.00 12.02 C +ATOM 8912 C VAL F 94 12.518 59.181 158.803 1.00 11.01 C +ATOM 8913 O VAL F 94 11.667 59.456 159.653 1.00 8.78 O +ATOM 8914 CB VAL F 94 12.752 56.702 158.048 1.00 13.92 C +ATOM 8915 CG1 VAL F 94 11.691 55.991 158.832 1.00 19.28 C +ATOM 8916 CG2 VAL F 94 12.186 57.183 156.723 1.00 14.36 C +ATOM 8917 N HIS F 95 12.878 60.026 157.845 1.00 8.50 N +ATOM 8918 CA HIS F 95 12.208 61.297 157.652 1.00 8.50 C +ATOM 8919 C HIS F 95 11.608 61.301 156.276 1.00 10.04 C +ATOM 8920 O HIS F 95 12.311 61.048 155.309 1.00 14.91 O +ATOM 8921 CB HIS F 95 13.235 62.443 157.776 1.00 16.04 C +ATOM 8922 CG HIS F 95 12.715 63.792 157.366 1.00 11.62 C +ATOM 8923 ND1 HIS F 95 12.075 64.653 158.235 1.00 9.01 N +ATOM 8924 CD2 HIS F 95 12.750 64.427 156.173 1.00 16.81 C +ATOM 8925 CE1 HIS F 95 11.736 65.756 157.593 1.00 9.22 C +ATOM 8926 NE2 HIS F 95 12.135 65.642 156.340 1.00 14.56 N +ATOM 8927 N ILE F 96 10.318 61.599 156.180 1.00 12.40 N +ATOM 8928 CA ILE F 96 9.658 61.655 154.880 1.00 10.37 C +ATOM 8929 C ILE F 96 8.912 62.979 154.663 1.00 8.50 C +ATOM 8930 O ILE F 96 8.476 63.617 155.615 1.00 8.50 O +ATOM 8931 CB ILE F 96 8.658 60.480 154.685 1.00 8.50 C +ATOM 8932 CG1 ILE F 96 7.601 60.510 155.769 1.00 16.49 C +ATOM 8933 CG2 ILE F 96 9.356 59.146 154.722 1.00 8.50 C +ATOM 8934 CD1 ILE F 96 6.443 59.598 155.481 1.00 27.10 C +ATOM 8935 N CYS F 97 8.879 63.425 153.412 1.00 10.54 N +ATOM 8936 CA CYS F 97 8.155 64.630 153.002 1.00 10.88 C +ATOM 8937 C CYS F 97 7.429 64.146 151.768 1.00 10.03 C +ATOM 8938 O CYS F 97 8.022 63.480 150.925 1.00 12.25 O +ATOM 8939 CB CYS F 97 9.075 65.782 152.561 1.00 8.50 C +ATOM 8940 SG CYS F 97 9.761 66.906 153.812 1.00 8.50 S +ATOM 8941 N THR F 98 6.154 64.453 151.670 1.00 8.50 N +ATOM 8942 CA THR F 98 5.386 64.044 150.522 1.00 8.50 C +ATOM 8943 C THR F 98 4.493 65.215 150.124 1.00 8.69 C +ATOM 8944 O THR F 98 4.055 65.989 150.985 1.00 8.50 O +ATOM 8945 CB THR F 98 4.574 62.770 150.835 1.00 13.31 C +ATOM 8946 OG1 THR F 98 3.842 62.367 149.673 1.00 17.81 O +ATOM 8947 CG2 THR F 98 3.606 62.999 151.992 1.00 16.99 C +ATOM 8948 N SER F 99 4.270 65.381 148.823 1.00 9.95 N +ATOM 8949 CA SER F 99 3.457 66.487 148.312 1.00 11.15 C +ATOM 8950 C SER F 99 2.570 66.117 147.140 1.00 13.25 C +ATOM 8951 O SER F 99 2.907 65.223 146.372 1.00 21.97 O +ATOM 8952 CB SER F 99 4.339 67.696 147.940 1.00 14.33 C +ATOM 8953 OG SER F 99 5.400 67.400 147.039 1.00 8.50 O +ATOM 8954 N TRP F 100 1.446 66.819 147.001 1.00 14.47 N +ATOM 8955 CA TRP F 100 0.479 66.577 145.924 1.00 13.00 C +ATOM 8956 C TRP F 100 -0.038 67.907 145.385 1.00 12.74 C +ATOM 8957 O TRP F 100 -0.197 68.867 146.136 1.00 15.25 O +ATOM 8958 CB TRP F 100 -0.684 65.722 146.447 1.00 13.67 C +ATOM 8959 CG TRP F 100 -1.885 65.675 145.564 1.00 8.86 C +ATOM 8960 CD1 TRP F 100 -2.066 64.883 144.478 1.00 12.98 C +ATOM 8961 CD2 TRP F 100 -3.078 66.456 145.698 1.00 8.50 C +ATOM 8962 NE1 TRP F 100 -3.300 65.122 143.921 1.00 15.84 N +ATOM 8963 CE2 TRP F 100 -3.939 66.085 144.653 1.00 11.35 C +ATOM 8964 CE3 TRP F 100 -3.504 67.428 146.603 1.00 8.50 C +ATOM 8965 CZ2 TRP F 100 -5.202 66.658 144.486 1.00 19.62 C +ATOM 8966 CZ3 TRP F 100 -4.756 67.993 146.442 1.00 8.50 C +ATOM 8967 CH2 TRP F 100 -5.590 67.611 145.395 1.00 12.32 C +ATOM 8968 N GLU F 101 -0.321 67.951 144.090 1.00 14.31 N +ATOM 8969 CA GLU F 101 -0.808 69.165 143.426 1.00 16.29 C +ATOM 8970 C GLU F 101 -2.010 68.829 142.559 1.00 17.95 C +ATOM 8971 O GLU F 101 -1.883 68.082 141.593 1.00 23.12 O +ATOM 8972 CB GLU F 101 0.309 69.738 142.543 1.00 17.82 C +ATOM 8973 CG GLU F 101 -0.082 70.927 141.701 1.00 25.19 C +ATOM 8974 CD GLU F 101 1.046 71.393 140.798 1.00 30.20 C +ATOM 8975 OE1 GLU F 101 1.300 70.707 139.789 1.00 16.01 O +ATOM 8976 OE2 GLU F 101 1.668 72.449 141.091 1.00 44.23 O +ATOM 8977 N SER F 102 -3.165 69.402 142.869 1.00 18.13 N +ATOM 8978 CA SER F 102 -4.376 69.121 142.097 1.00 17.31 C +ATOM 8979 C SER F 102 -4.189 69.409 140.624 1.00 17.50 C +ATOM 8980 O SER F 102 -4.487 68.572 139.783 1.00 23.62 O +ATOM 8981 CB SER F 102 -5.570 69.925 142.627 1.00 17.99 C +ATOM 8982 OG SER F 102 -6.693 69.839 141.757 1.00 8.50 O +ATOM 8983 N ALA F 103 -3.628 70.570 140.322 1.00 16.84 N +ATOM 8984 CA ALA F 103 -3.415 70.999 138.940 1.00 16.05 C +ATOM 8985 C ALA F 103 -2.761 70.018 137.965 1.00 14.56 C +ATOM 8986 O ALA F 103 -3.024 70.092 136.773 1.00 25.26 O +ATOM 8987 CB ALA F 103 -2.664 72.326 138.924 1.00 24.16 C +ATOM 8988 N SER F 104 -1.929 69.104 138.450 1.00 11.62 N +ATOM 8989 CA SER F 104 -1.261 68.158 137.556 1.00 12.66 C +ATOM 8990 C SER F 104 -1.341 66.699 138.034 1.00 13.85 C +ATOM 8991 O SER F 104 -1.123 65.750 137.258 1.00 11.29 O +ATOM 8992 CB SER F 104 0.200 68.562 137.430 1.00 12.29 C +ATOM 8993 OG SER F 104 0.845 68.396 138.681 1.00 19.42 O +ATOM 8994 N GLY F 105 -1.626 66.543 139.321 1.00 12.56 N +ATOM 8995 CA GLY F 105 -1.712 65.231 139.913 1.00 11.22 C +ATOM 8996 C GLY F 105 -0.344 64.737 140.309 1.00 13.02 C +ATOM 8997 O GLY F 105 -0.221 63.626 140.816 1.00 22.19 O +ATOM 8998 N ILE F 106 0.686 65.547 140.098 1.00 8.50 N +ATOM 8999 CA ILE F 106 2.027 65.124 140.452 1.00 8.50 C +ATOM 9000 C ILE F 106 2.258 65.035 141.954 1.00 8.50 C +ATOM 9001 O ILE F 106 2.086 66.006 142.678 1.00 11.63 O +ATOM 9002 CB ILE F 106 3.100 66.012 139.831 1.00 8.50 C +ATOM 9003 CG1 ILE F 106 3.060 65.893 138.325 1.00 8.50 C +ATOM 9004 CG2 ILE F 106 4.464 65.581 140.302 1.00 8.50 C +ATOM 9005 CD1 ILE F 106 4.104 66.703 137.651 1.00 8.50 C +ATOM 9006 N VAL F 107 2.645 63.853 142.408 1.00 8.50 N +ATOM 9007 CA VAL F 107 2.934 63.614 143.797 1.00 8.50 C +ATOM 9008 C VAL F 107 4.400 63.219 143.908 1.00 8.50 C +ATOM 9009 O VAL F 107 4.891 62.451 143.093 1.00 11.55 O +ATOM 9010 CB VAL F 107 1.985 62.545 144.397 1.00 8.50 C +ATOM 9011 CG1 VAL F 107 1.730 61.439 143.427 1.00 13.41 C +ATOM 9012 CG2 VAL F 107 2.579 61.970 145.645 1.00 19.34 C +ATOM 9013 N GLU F 108 5.118 63.842 144.840 1.00 9.33 N +ATOM 9014 CA GLU F 108 6.542 63.574 145.079 1.00 8.50 C +ATOM 9015 C GLU F 108 6.631 62.888 146.432 1.00 11.62 C +ATOM 9016 O GLU F 108 5.820 63.166 147.318 1.00 9.78 O +ATOM 9017 CB GLU F 108 7.353 64.882 145.198 1.00 8.50 C +ATOM 9018 CG GLU F 108 7.429 65.800 143.981 1.00 8.50 C +ATOM 9019 CD GLU F 108 8.052 67.155 144.308 1.00 15.98 C +ATOM 9020 OE1 GLU F 108 8.338 67.444 145.489 1.00 23.53 O +ATOM 9021 OE2 GLU F 108 8.225 67.967 143.387 1.00 30.80 O +ATOM 9022 N PHE F 109 7.615 62.008 146.606 1.00 15.00 N +ATOM 9023 CA PHE F 109 7.809 61.332 147.889 1.00 9.76 C +ATOM 9024 C PHE F 109 9.305 61.409 148.127 1.00 8.50 C +ATOM 9025 O PHE F 109 10.083 60.973 147.281 1.00 10.24 O +ATOM 9026 CB PHE F 109 7.342 59.880 147.808 1.00 9.54 C +ATOM 9027 CG PHE F 109 6.933 59.298 149.133 1.00 14.34 C +ATOM 9028 CD1 PHE F 109 5.639 59.462 149.611 1.00 8.50 C +ATOM 9029 CD2 PHE F 109 7.849 58.590 149.910 1.00 14.87 C +ATOM 9030 CE1 PHE F 109 5.265 58.937 150.839 1.00 8.50 C +ATOM 9031 CE2 PHE F 109 7.480 58.063 151.139 1.00 8.50 C +ATOM 9032 CZ PHE F 109 6.191 58.238 151.602 1.00 8.50 C +ATOM 9033 N TRP F 110 9.701 62.073 149.206 1.00 8.50 N +ATOM 9034 CA TRP F 110 11.110 62.235 149.539 1.00 10.26 C +ATOM 9035 C TRP F 110 11.400 61.446 150.791 1.00 10.92 C +ATOM 9036 O TRP F 110 10.800 61.711 151.828 1.00 13.28 O +ATOM 9037 CB TRP F 110 11.442 63.705 149.832 1.00 9.81 C +ATOM 9038 CG TRP F 110 11.252 64.623 148.690 1.00 8.50 C +ATOM 9039 CD1 TRP F 110 10.068 64.996 148.127 1.00 8.50 C +ATOM 9040 CD2 TRP F 110 12.280 65.277 147.939 1.00 8.50 C +ATOM 9041 NE1 TRP F 110 10.294 65.833 147.067 1.00 8.50 N +ATOM 9042 CE2 TRP F 110 11.644 66.023 146.929 1.00 8.50 C +ATOM 9043 CE3 TRP F 110 13.676 65.304 148.022 1.00 8.89 C +ATOM 9044 CZ2 TRP F 110 12.354 66.786 146.009 1.00 8.50 C +ATOM 9045 CZ3 TRP F 110 14.382 66.069 147.104 1.00 8.57 C +ATOM 9046 CH2 TRP F 110 13.716 66.798 146.113 1.00 8.50 C +ATOM 9047 N VAL F 111 12.330 60.504 150.711 1.00 8.50 N +ATOM 9048 CA VAL F 111 12.692 59.720 151.877 1.00 8.50 C +ATOM 9049 C VAL F 111 14.123 60.071 152.239 1.00 11.54 C +ATOM 9050 O VAL F 111 15.025 59.939 151.419 1.00 14.50 O +ATOM 9051 CB VAL F 111 12.574 58.223 151.619 1.00 8.50 C +ATOM 9052 CG1 VAL F 111 12.927 57.448 152.856 1.00 8.50 C +ATOM 9053 CG2 VAL F 111 11.169 57.889 151.191 1.00 11.96 C +ATOM 9054 N ASP F 112 14.306 60.567 153.458 1.00 13.09 N +ATOM 9055 CA ASP F 112 15.608 60.975 153.974 1.00 9.05 C +ATOM 9056 C ASP F 112 16.334 62.002 153.114 1.00 10.88 C +ATOM 9057 O ASP F 112 17.547 61.920 152.923 1.00 12.57 O +ATOM 9058 CB ASP F 112 16.505 59.771 154.243 1.00 8.50 C +ATOM 9059 CG ASP F 112 16.208 59.109 155.567 1.00 8.50 C +ATOM 9060 OD1 ASP F 112 15.777 59.804 156.517 1.00 20.70 O +ATOM 9061 OD2 ASP F 112 16.422 57.885 155.674 1.00 12.53 O +ATOM 9062 N GLY F 113 15.585 62.975 152.601 1.00 12.22 N +ATOM 9063 CA GLY F 113 16.184 64.020 151.790 1.00 11.61 C +ATOM 9064 C GLY F 113 16.427 63.702 150.336 1.00 11.34 C +ATOM 9065 O GLY F 113 16.815 64.585 149.562 1.00 14.22 O +ATOM 9066 N LYS F 114 16.211 62.444 149.969 1.00 10.49 N +ATOM 9067 CA LYS F 114 16.400 61.980 148.601 1.00 9.35 C +ATOM 9068 C LYS F 114 15.035 61.675 147.973 1.00 9.43 C +ATOM 9069 O LYS F 114 14.218 60.950 148.549 1.00 9.99 O +ATOM 9070 CB LYS F 114 17.341 60.757 148.596 1.00 13.67 C +ATOM 9071 CG LYS F 114 18.813 61.117 148.228 1.00 21.42 C +ATOM 9072 CD LYS F 114 19.895 60.724 149.258 1.00 19.70 C +ATOM 9073 CE LYS F 114 21.265 61.295 148.811 1.00 16.61 C +ATOM 9074 NZ LYS F 114 22.437 61.108 149.739 1.00 24.31 N +ATOM 9075 N PRO F 115 14.765 62.249 146.786 1.00 10.01 N +ATOM 9076 CA PRO F 115 13.514 62.088 146.049 1.00 9.54 C +ATOM 9077 C PRO F 115 13.312 60.794 145.294 1.00 10.73 C +ATOM 9078 O PRO F 115 14.247 60.246 144.698 1.00 13.84 O +ATOM 9079 CB PRO F 115 13.572 63.250 145.063 1.00 8.50 C +ATOM 9080 CG PRO F 115 14.995 63.218 144.661 1.00 8.50 C +ATOM 9081 CD PRO F 115 15.712 63.061 145.994 1.00 12.56 C +ATOM 9082 N ARG F 116 12.075 60.323 145.318 1.00 8.50 N +ATOM 9083 CA ARG F 116 11.680 59.137 144.578 1.00 11.61 C +ATOM 9084 C ARG F 116 11.136 59.784 143.310 1.00 12.45 C +ATOM 9085 O ARG F 116 10.914 61.000 143.290 1.00 12.24 O +ATOM 9086 CB ARG F 116 10.552 58.393 145.308 1.00 14.29 C +ATOM 9087 CG ARG F 116 10.898 58.002 146.734 1.00 19.45 C +ATOM 9088 CD ARG F 116 11.853 56.820 146.785 1.00 39.10 C +ATOM 9089 NE ARG F 116 11.164 55.559 146.497 1.00 46.12 N +ATOM 9090 CZ ARG F 116 11.166 54.953 145.311 1.00 48.60 C +ATOM 9091 NH1 ARG F 116 11.829 55.490 144.284 1.00 49.25 N +ATOM 9092 NH2 ARG F 116 10.504 53.812 145.154 1.00 43.94 N +ATOM 9093 N VAL F 117 10.883 58.997 142.271 1.00 13.32 N +ATOM 9094 CA VAL F 117 10.364 59.567 141.026 1.00 11.03 C +ATOM 9095 C VAL F 117 8.991 60.201 141.226 1.00 15.33 C +ATOM 9096 O VAL F 117 8.315 59.939 142.221 1.00 20.98 O +ATOM 9097 CB VAL F 117 10.249 58.533 139.911 1.00 8.50 C +ATOM 9098 CG1 VAL F 117 10.274 59.234 138.580 1.00 12.47 C +ATOM 9099 CG2 VAL F 117 11.372 57.528 140.005 1.00 8.50 C +ATOM 9100 N ARG F 118 8.598 61.065 140.299 1.00 15.11 N +ATOM 9101 CA ARG F 118 7.304 61.737 140.396 1.00 12.34 C +ATOM 9102 C ARG F 118 6.229 60.882 139.781 1.00 8.50 C +ATOM 9103 O ARG F 118 6.422 60.323 138.712 1.00 17.91 O +ATOM 9104 CB ARG F 118 7.329 63.094 139.684 1.00 15.15 C +ATOM 9105 CG ARG F 118 8.384 64.065 140.172 1.00 8.55 C +ATOM 9106 CD ARG F 118 8.087 65.442 139.617 1.00 18.66 C +ATOM 9107 NE ARG F 118 9.292 66.206 139.307 1.00 12.96 N +ATOM 9108 CZ ARG F 118 9.715 67.247 140.002 1.00 8.50 C +ATOM 9109 NH1 ARG F 118 9.047 67.661 141.045 1.00 8.50 N +ATOM 9110 NH2 ARG F 118 10.809 67.864 139.656 1.00 8.50 N +ATOM 9111 N LYS F 119 5.082 60.821 140.428 1.00 8.50 N +ATOM 9112 CA LYS F 119 3.974 60.023 139.933 1.00 8.50 C +ATOM 9113 C LYS F 119 2.713 60.862 139.828 1.00 8.50 C +ATOM 9114 O LYS F 119 2.667 61.956 140.347 1.00 14.50 O +ATOM 9115 CB LYS F 119 3.767 58.825 140.854 1.00 9.73 C +ATOM 9116 CG LYS F 119 4.958 57.882 140.847 1.00 10.54 C +ATOM 9117 CD LYS F 119 4.714 56.606 141.619 1.00 14.62 C +ATOM 9118 CE LYS F 119 5.806 55.589 141.311 1.00 27.16 C +ATOM 9119 NZ LYS F 119 5.638 54.304 142.055 1.00 37.72 N +ATOM 9120 N SER F 120 1.707 60.373 139.123 1.00 11.49 N +ATOM 9121 CA SER F 120 0.453 61.104 138.959 1.00 10.48 C +ATOM 9122 C SER F 120 -0.638 60.469 139.820 1.00 11.06 C +ATOM 9123 O SER F 120 -0.730 59.241 139.907 1.00 17.36 O +ATOM 9124 CB SER F 120 0.034 61.097 137.490 1.00 8.50 C +ATOM 9125 OG SER F 120 -0.903 62.116 137.198 1.00 15.80 O +ATOM 9126 N LEU F 121 -1.467 61.294 140.453 1.00 10.30 N +ATOM 9127 CA LEU F 121 -2.532 60.795 141.315 1.00 13.56 C +ATOM 9128 C LEU F 121 -3.563 61.866 141.646 1.00 17.55 C +ATOM 9129 O LEU F 121 -3.216 62.966 142.070 1.00 13.85 O +ATOM 9130 CB LEU F 121 -1.945 60.224 142.614 1.00 15.26 C +ATOM 9131 CG LEU F 121 -2.883 59.906 143.776 1.00 8.50 C +ATOM 9132 CD1 LEU F 121 -3.935 58.939 143.359 1.00 8.50 C +ATOM 9133 CD2 LEU F 121 -2.067 59.337 144.910 1.00 15.59 C +ATOM 9134 N LYS F 122 -4.829 61.527 141.402 1.00 22.17 N +ATOM 9135 CA LYS F 122 -5.975 62.400 141.671 1.00 15.97 C +ATOM 9136 C LYS F 122 -5.921 63.817 141.105 1.00 18.12 C +ATOM 9137 O LYS F 122 -6.191 64.791 141.826 1.00 15.26 O +ATOM 9138 CB LYS F 122 -6.247 62.469 143.177 1.00 20.65 C +ATOM 9139 CG LYS F 122 -7.060 61.305 143.702 1.00 29.59 C +ATOM 9140 CD LYS F 122 -8.494 61.357 143.183 1.00 36.26 C +ATOM 9141 CE LYS F 122 -9.328 60.194 143.734 1.00 37.85 C +ATOM 9142 NZ LYS F 122 -10.760 60.260 143.305 1.00 50.99 N +ATOM 9143 N LYS F 123 -5.607 63.937 139.816 1.00 17.35 N +ATOM 9144 CA LYS F 123 -5.544 65.254 139.191 1.00 17.73 C +ATOM 9145 C LYS F 123 -6.925 65.895 139.226 1.00 20.00 C +ATOM 9146 O LYS F 123 -7.935 65.208 139.076 1.00 25.95 O +ATOM 9147 CB LYS F 123 -5.070 65.173 137.739 1.00 11.68 C +ATOM 9148 CG LYS F 123 -5.035 66.537 137.084 1.00 13.12 C +ATOM 9149 CD LYS F 123 -5.192 66.480 135.585 1.00 20.56 C +ATOM 9150 CE LYS F 123 -3.903 66.096 134.890 1.00 12.88 C +ATOM 9151 NZ LYS F 123 -4.036 66.390 133.439 1.00 19.16 N +ATOM 9152 N GLY F 124 -6.965 67.203 139.446 1.00 21.90 N +ATOM 9153 CA GLY F 124 -8.231 67.907 139.488 1.00 22.00 C +ATOM 9154 C GLY F 124 -9.015 67.752 140.777 1.00 22.10 C +ATOM 9155 O GLY F 124 -9.962 68.510 141.017 1.00 28.66 O +ATOM 9156 N TYR F 125 -8.651 66.773 141.599 1.00 18.82 N +ATOM 9157 CA TYR F 125 -9.345 66.555 142.864 1.00 20.68 C +ATOM 9158 C TYR F 125 -9.110 67.770 143.781 1.00 22.77 C +ATOM 9159 O TYR F 125 -8.318 68.665 143.469 1.00 23.81 O +ATOM 9160 CB TYR F 125 -8.831 65.277 143.538 1.00 19.86 C +ATOM 9161 CG TYR F 125 -9.604 64.865 144.776 1.00 26.34 C +ATOM 9162 CD1 TYR F 125 -10.801 64.162 144.663 1.00 27.75 C +ATOM 9163 CD2 TYR F 125 -9.125 65.157 146.067 1.00 29.19 C +ATOM 9164 CE1 TYR F 125 -11.501 63.752 145.802 1.00 33.57 C +ATOM 9165 CE2 TYR F 125 -9.822 64.757 147.216 1.00 24.35 C +ATOM 9166 CZ TYR F 125 -11.009 64.051 147.078 1.00 29.42 C +ATOM 9167 OH TYR F 125 -11.711 63.630 148.195 1.00 25.29 O +ATOM 9168 N THR F 126 -9.822 67.808 144.898 1.00 23.48 N +ATOM 9169 CA THR F 126 -9.680 68.890 145.861 1.00 24.72 C +ATOM 9170 C THR F 126 -9.953 68.318 147.272 1.00 26.01 C +ATOM 9171 O THR F 126 -11.008 67.725 147.538 1.00 25.55 O +ATOM 9172 CB THR F 126 -10.585 70.111 145.477 1.00 19.23 C +ATOM 9173 OG1 THR F 126 -10.789 70.944 146.620 1.00 21.82 O +ATOM 9174 CG2 THR F 126 -11.927 69.661 144.891 1.00 23.55 C +ATOM 9175 N VAL F 127 -8.942 68.409 148.132 1.00 23.65 N +ATOM 9176 CA VAL F 127 -9.015 67.874 149.487 1.00 18.99 C +ATOM 9177 C VAL F 127 -9.921 68.686 150.409 1.00 19.87 C +ATOM 9178 O VAL F 127 -9.882 69.918 150.394 1.00 18.44 O +ATOM 9179 CB VAL F 127 -7.586 67.745 150.093 1.00 15.06 C +ATOM 9180 CG1 VAL F 127 -7.643 67.297 151.538 1.00 20.63 C +ATOM 9181 CG2 VAL F 127 -6.773 66.757 149.282 1.00 8.50 C +ATOM 9182 N GLY F 128 -10.716 67.981 151.220 1.00 21.58 N +ATOM 9183 CA GLY F 128 -11.642 68.614 152.153 1.00 26.29 C +ATOM 9184 C GLY F 128 -10.959 69.437 153.226 1.00 30.82 C +ATOM 9185 O GLY F 128 -9.920 69.021 153.748 1.00 31.41 O +ATOM 9186 N ALA F 129 -11.572 70.574 153.576 1.00 34.87 N +ATOM 9187 CA ALA F 129 -11.034 71.508 154.575 1.00 34.14 C +ATOM 9188 C ALA F 129 -11.272 71.145 156.043 1.00 40.68 C +ATOM 9189 O ALA F 129 -10.421 71.417 156.892 1.00 44.89 O +ATOM 9190 CB ALA F 129 -11.538 72.912 154.298 1.00 35.01 C +ATOM 9191 N GLU F 130 -12.441 70.600 156.366 1.00 44.61 N +ATOM 9192 CA GLU F 130 -12.713 70.216 157.749 1.00 50.38 C +ATOM 9193 C GLU F 130 -12.351 68.746 157.897 1.00 44.21 C +ATOM 9194 O GLU F 130 -13.016 67.867 157.341 1.00 42.31 O +ATOM 9195 CB GLU F 130 -14.173 70.478 158.129 1.00 67.44 C +ATOM 9196 CG GLU F 130 -15.203 69.834 157.214 1.00 89.98 C +ATOM 9197 CD GLU F 130 -16.621 70.131 157.655 1.00101.48 C +ATOM 9198 OE1 GLU F 130 -17.165 71.183 157.244 1.00110.79 O +ATOM 9199 OE2 GLU F 130 -17.185 69.321 158.423 1.00106.70 O +ATOM 9200 N ALA F 131 -11.290 68.483 158.649 1.00 40.59 N +ATOM 9201 CA ALA F 131 -10.825 67.121 158.803 1.00 31.90 C +ATOM 9202 C ALA F 131 -10.309 66.743 160.175 1.00 25.45 C +ATOM 9203 O ALA F 131 -9.946 67.601 160.990 1.00 31.47 O +ATOM 9204 CB ALA F 131 -9.745 66.852 157.778 1.00 35.79 C +ATOM 9205 N SER F 132 -10.278 65.436 160.407 1.00 18.07 N +ATOM 9206 CA SER F 132 -9.779 64.857 161.643 1.00 22.36 C +ATOM 9207 C SER F 132 -8.425 64.291 161.246 1.00 23.25 C +ATOM 9208 O SER F 132 -8.342 63.428 160.364 1.00 21.47 O +ATOM 9209 CB SER F 132 -10.711 63.736 162.126 1.00 24.98 C +ATOM 9210 OG SER F 132 -10.225 63.126 163.312 1.00 33.72 O +ATOM 9211 N ILE F 133 -7.371 64.844 161.839 1.00 21.86 N +ATOM 9212 CA ILE F 133 -5.996 64.429 161.565 1.00 15.80 C +ATOM 9213 C ILE F 133 -5.492 63.640 162.768 1.00 14.77 C +ATOM 9214 O ILE F 133 -5.368 64.185 163.868 1.00 16.94 O +ATOM 9215 CB ILE F 133 -5.095 65.668 161.348 1.00 20.89 C +ATOM 9216 CG1 ILE F 133 -5.703 66.566 160.259 1.00 26.16 C +ATOM 9217 CG2 ILE F 133 -3.693 65.241 160.954 1.00 19.41 C +ATOM 9218 CD1 ILE F 133 -4.954 67.861 160.033 1.00 19.23 C +ATOM 9219 N ILE F 134 -5.194 62.361 162.565 1.00 11.64 N +ATOM 9220 CA ILE F 134 -4.738 61.537 163.664 1.00 11.56 C +ATOM 9221 C ILE F 134 -3.400 60.880 163.451 1.00 11.19 C +ATOM 9222 O ILE F 134 -3.065 60.440 162.352 1.00 14.51 O +ATOM 9223 CB ILE F 134 -5.815 60.508 164.051 1.00 19.02 C +ATOM 9224 CG1 ILE F 134 -6.929 61.223 164.820 1.00 22.57 C +ATOM 9225 CG2 ILE F 134 -5.219 59.349 164.857 1.00 20.37 C +ATOM 9226 CD1 ILE F 134 -8.065 60.332 165.228 1.00 31.37 C +ATOM 9227 N LEU F 135 -2.638 60.834 164.531 1.00 8.73 N +ATOM 9228 CA LEU F 135 -1.317 60.242 164.538 1.00 10.64 C +ATOM 9229 C LEU F 135 -1.355 58.933 165.321 1.00 16.92 C +ATOM 9230 O LEU F 135 -1.961 58.864 166.398 1.00 14.54 O +ATOM 9231 CB LEU F 135 -0.329 61.196 165.209 1.00 8.50 C +ATOM 9232 CG LEU F 135 0.557 62.118 164.371 1.00 12.45 C +ATOM 9233 CD1 LEU F 135 -0.162 62.635 163.146 1.00 13.62 C +ATOM 9234 CD2 LEU F 135 1.051 63.264 165.232 1.00 15.44 C +ATOM 9235 N GLY F 136 -0.752 57.885 164.761 1.00 21.54 N +ATOM 9236 CA GLY F 136 -0.701 56.607 165.463 1.00 25.81 C +ATOM 9237 C GLY F 136 -1.816 55.587 165.258 1.00 27.19 C +ATOM 9238 O GLY F 136 -1.661 54.430 165.646 1.00 24.02 O +ATOM 9239 N GLN F 137 -2.953 56.012 164.714 1.00 22.68 N +ATOM 9240 CA GLN F 137 -4.054 55.097 164.466 1.00 17.75 C +ATOM 9241 C GLN F 137 -4.560 55.247 163.051 1.00 22.98 C +ATOM 9242 O GLN F 137 -4.364 56.297 162.433 1.00 27.11 O +ATOM 9243 CB GLN F 137 -5.207 55.362 165.422 1.00 19.43 C +ATOM 9244 CG GLN F 137 -5.032 54.731 166.767 1.00 11.21 C +ATOM 9245 CD GLN F 137 -4.707 53.259 166.687 1.00 23.29 C +ATOM 9246 OE1 GLN F 137 -4.142 52.704 167.621 1.00 31.64 O +ATOM 9247 NE2 GLN F 137 -5.084 52.607 165.584 1.00 21.96 N +ATOM 9248 N GLU F 138 -5.229 54.215 162.539 1.00 23.43 N +ATOM 9249 CA GLU F 138 -5.762 54.275 161.183 1.00 22.41 C +ATOM 9250 C GLU F 138 -7.251 54.587 161.190 1.00 25.97 C +ATOM 9251 O GLU F 138 -8.062 53.749 161.600 1.00 27.70 O +ATOM 9252 CB GLU F 138 -5.519 52.954 160.459 1.00 20.90 C +ATOM 9253 CG GLU F 138 -5.442 53.086 158.924 1.00 38.06 C +ATOM 9254 CD GLU F 138 -6.781 53.432 158.235 1.00 42.74 C +ATOM 9255 OE1 GLU F 138 -7.533 52.496 157.894 1.00 45.26 O +ATOM 9256 OE2 GLU F 138 -7.061 54.631 157.992 1.00 33.99 O +ATOM 9257 N GLN F 139 -7.605 55.785 160.728 1.00 25.73 N +ATOM 9258 CA GLN F 139 -9.005 56.200 160.667 1.00 28.23 C +ATOM 9259 C GLN F 139 -9.807 55.521 159.545 1.00 40.30 C +ATOM 9260 O GLN F 139 -9.366 55.430 158.376 1.00 39.06 O +ATOM 9261 CB GLN F 139 -9.117 57.703 160.496 1.00 17.17 C +ATOM 9262 CG GLN F 139 -9.286 58.454 161.775 1.00 24.86 C +ATOM 9263 CD GLN F 139 -8.926 59.931 161.638 1.00 30.95 C +ATOM 9264 OE1 GLN F 139 -7.781 60.307 161.854 1.00 41.49 O +ATOM 9265 NE2 GLN F 139 -9.892 60.762 161.250 1.00 24.01 N +ATOM 9266 N ASP F 140 -10.997 55.058 159.917 1.00 45.59 N +ATOM 9267 CA ASP F 140 -11.916 54.414 158.988 1.00 46.98 C +ATOM 9268 C ASP F 140 -13.288 55.066 159.124 1.00 47.70 C +ATOM 9269 O ASP F 140 -14.280 54.599 158.567 1.00 53.95 O +ATOM 9270 CB ASP F 140 -11.960 52.905 159.225 1.00 46.08 C +ATOM 9271 CG ASP F 140 -10.705 52.220 158.746 1.00 47.10 C +ATOM 9272 OD1 ASP F 140 -10.220 52.573 157.647 1.00 46.14 O +ATOM 9273 OD2 ASP F 140 -10.195 51.352 159.478 1.00 49.49 O +ATOM 9274 N SER F 141 -13.313 56.168 159.868 1.00 45.08 N +ATOM 9275 CA SER F 141 -14.507 56.970 160.095 1.00 44.78 C +ATOM 9276 C SER F 141 -13.971 58.254 160.702 1.00 38.26 C +ATOM 9277 O SER F 141 -12.912 58.253 161.326 1.00 38.94 O +ATOM 9278 CB SER F 141 -15.486 56.284 161.072 1.00 55.81 C +ATOM 9279 OG SER F 141 -15.111 56.435 162.444 1.00 56.04 O +ATOM 9280 N PHE F 142 -14.683 59.350 160.504 1.00 33.67 N +ATOM 9281 CA PHE F 142 -14.251 60.628 161.035 1.00 33.04 C +ATOM 9282 C PHE F 142 -13.923 60.561 162.521 1.00 34.04 C +ATOM 9283 O PHE F 142 -14.810 60.515 163.362 1.00 41.21 O +ATOM 9284 CB PHE F 142 -15.324 61.675 160.783 1.00 39.69 C +ATOM 9285 CG PHE F 142 -14.857 63.085 160.992 1.00 47.16 C +ATOM 9286 CD1 PHE F 142 -14.263 63.795 159.950 1.00 47.15 C +ATOM 9287 CD2 PHE F 142 -15.073 63.733 162.211 1.00 55.97 C +ATOM 9288 CE1 PHE F 142 -13.897 65.139 160.111 1.00 54.82 C +ATOM 9289 CE2 PHE F 142 -14.713 65.078 162.386 1.00 57.94 C +ATOM 9290 CZ PHE F 142 -14.125 65.783 161.333 1.00 55.07 C +ATOM 9291 N GLY F 143 -12.633 60.517 162.824 1.00 36.52 N +ATOM 9292 CA GLY F 143 -12.179 60.472 164.200 1.00 35.23 C +ATOM 9293 C GLY F 143 -12.306 59.144 164.933 1.00 38.41 C +ATOM 9294 O GLY F 143 -12.149 59.100 166.161 1.00 40.52 O +ATOM 9295 N GLY F 144 -12.545 58.058 164.203 1.00 37.71 N +ATOM 9296 CA GLY F 144 -12.679 56.764 164.853 1.00 43.73 C +ATOM 9297 C GLY F 144 -12.547 55.533 163.971 1.00 45.12 C +ATOM 9298 O GLY F 144 -12.048 55.611 162.842 1.00 44.32 O +ATOM 9299 N ASN F 145 -13.011 54.399 164.504 1.00 48.61 N +ATOM 9300 CA ASN F 145 -12.964 53.103 163.828 1.00 49.94 C +ATOM 9301 C ASN F 145 -11.527 52.664 163.610 1.00 45.50 C +ATOM 9302 O ASN F 145 -11.097 52.382 162.483 1.00 44.96 O +ATOM 9303 CB ASN F 145 -13.736 53.142 162.509 1.00 57.94 C +ATOM 9304 CG ASN F 145 -15.228 52.983 162.710 1.00 66.71 C +ATOM 9305 OD1 ASN F 145 -15.871 53.800 163.382 1.00 66.28 O +ATOM 9306 ND2 ASN F 145 -15.790 51.923 162.134 1.00 69.48 N +ATOM 9307 N PHE F 146 -10.806 52.563 164.722 1.00 41.06 N +ATOM 9308 CA PHE F 146 -9.393 52.192 164.712 1.00 43.65 C +ATOM 9309 C PHE F 146 -9.114 50.693 164.691 1.00 44.38 C +ATOM 9310 O PHE F 146 -9.569 49.962 165.567 1.00 47.32 O +ATOM 9311 CB PHE F 146 -8.676 52.804 165.928 1.00 34.17 C +ATOM 9312 CG PHE F 146 -8.830 54.291 166.044 1.00 30.59 C +ATOM 9313 CD1 PHE F 146 -8.806 55.107 164.908 1.00 29.56 C +ATOM 9314 CD2 PHE F 146 -9.027 54.877 167.288 1.00 23.83 C +ATOM 9315 CE1 PHE F 146 -8.982 56.481 165.015 1.00 32.47 C +ATOM 9316 CE2 PHE F 146 -9.204 56.257 167.402 1.00 30.17 C +ATOM 9317 CZ PHE F 146 -9.183 57.061 166.269 1.00 26.95 C +ATOM 9318 N GLU F 147 -8.359 50.245 163.690 1.00 47.59 N +ATOM 9319 CA GLU F 147 -7.974 48.835 163.579 1.00 50.86 C +ATOM 9320 C GLU F 147 -6.591 48.723 164.228 1.00 49.88 C +ATOM 9321 O GLU F 147 -5.633 49.346 163.764 1.00 52.63 O +ATOM 9322 CB GLU F 147 -7.890 48.397 162.100 1.00 58.26 C +ATOM 9323 CG GLU F 147 -9.211 48.502 161.298 1.00 69.66 C +ATOM 9324 CD GLU F 147 -9.059 48.210 159.788 1.00 73.99 C +ATOM 9325 OE1 GLU F 147 -8.067 47.559 159.383 1.00 81.16 O +ATOM 9326 OE2 GLU F 147 -9.942 48.628 158.996 1.00 61.07 O +ATOM 9327 N GLY F 148 -6.496 47.951 165.308 1.00 51.11 N +ATOM 9328 CA GLY F 148 -5.235 47.787 166.020 1.00 47.83 C +ATOM 9329 C GLY F 148 -4.118 47.152 165.218 1.00 45.91 C +ATOM 9330 O GLY F 148 -2.947 47.243 165.594 1.00 50.23 O +ATOM 9331 N SER F 149 -4.484 46.516 164.110 1.00 42.84 N +ATOM 9332 CA SER F 149 -3.533 45.858 163.222 1.00 43.94 C +ATOM 9333 C SER F 149 -2.804 46.898 162.356 1.00 40.34 C +ATOM 9334 O SER F 149 -1.911 46.558 161.560 1.00 42.36 O +ATOM 9335 CB SER F 149 -4.303 44.868 162.334 1.00 52.39 C +ATOM 9336 OG SER F 149 -3.435 44.093 161.523 1.00 78.21 O +ATOM 9337 N GLN F 150 -3.192 48.163 162.521 1.00 31.86 N +ATOM 9338 CA GLN F 150 -2.632 49.262 161.749 1.00 23.45 C +ATOM 9339 C GLN F 150 -2.200 50.388 162.673 1.00 28.92 C +ATOM 9340 O GLN F 150 -2.072 51.541 162.257 1.00 41.69 O +ATOM 9341 CB GLN F 150 -3.689 49.772 160.749 1.00 23.85 C +ATOM 9342 CG GLN F 150 -4.369 48.651 159.948 1.00 26.91 C +ATOM 9343 CD GLN F 150 -5.204 49.136 158.794 1.00 22.46 C +ATOM 9344 OE1 GLN F 150 -6.108 49.938 158.969 1.00 19.35 O +ATOM 9345 NE2 GLN F 150 -4.917 48.626 157.600 1.00 38.21 N +ATOM 9346 N SER F 151 -2.007 50.070 163.943 1.00 29.72 N +ATOM 9347 CA SER F 151 -1.590 51.077 164.907 1.00 30.32 C +ATOM 9348 C SER F 151 -0.082 51.259 164.799 1.00 25.42 C +ATOM 9349 O SER F 151 0.609 50.389 164.278 1.00 28.32 O +ATOM 9350 CB SER F 151 -1.952 50.635 166.326 1.00 40.52 C +ATOM 9351 OG SER F 151 -1.612 51.647 167.267 1.00 63.89 O +ATOM 9352 N LEU F 152 0.426 52.395 165.253 1.00 19.90 N +ATOM 9353 CA LEU F 152 1.856 52.606 165.197 1.00 13.69 C +ATOM 9354 C LEU F 152 2.482 52.374 166.563 1.00 12.38 C +ATOM 9355 O LEU F 152 1.980 52.851 167.580 1.00 11.95 O +ATOM 9356 CB LEU F 152 2.189 54.021 164.724 1.00 18.15 C +ATOM 9357 CG LEU F 152 3.670 54.426 164.839 1.00 14.11 C +ATOM 9358 CD1 LEU F 152 4.466 53.873 163.686 1.00 8.50 C +ATOM 9359 CD2 LEU F 152 3.779 55.930 164.854 1.00 20.94 C +ATOM 9360 N VAL F 153 3.584 51.640 166.576 1.00 11.85 N +ATOM 9361 CA VAL F 153 4.298 51.366 167.806 1.00 12.51 C +ATOM 9362 C VAL F 153 5.716 51.878 167.605 1.00 13.32 C +ATOM 9363 O VAL F 153 6.488 51.303 166.833 1.00 10.28 O +ATOM 9364 CB VAL F 153 4.339 49.851 168.137 1.00 12.59 C +ATOM 9365 CG1 VAL F 153 4.832 49.644 169.560 1.00 12.77 C +ATOM 9366 CG2 VAL F 153 2.973 49.224 167.949 1.00 8.50 C +ATOM 9367 N GLY F 154 6.023 52.986 168.271 1.00 11.90 N +ATOM 9368 CA GLY F 154 7.337 53.597 168.175 1.00 9.42 C +ATOM 9369 C GLY F 154 7.203 55.084 168.415 1.00 12.69 C +ATOM 9370 O GLY F 154 6.267 55.515 169.093 1.00 14.63 O +ATOM 9371 N ASP F 155 8.107 55.871 167.842 1.00 10.87 N +ATOM 9372 CA ASP F 155 8.079 57.322 167.993 1.00 8.50 C +ATOM 9373 C ASP F 155 7.699 58.012 166.697 1.00 9.20 C +ATOM 9374 O ASP F 155 7.994 57.530 165.610 1.00 9.73 O +ATOM 9375 CB ASP F 155 9.450 57.844 168.382 1.00 8.50 C +ATOM 9376 CG ASP F 155 9.855 57.424 169.747 1.00 12.42 C +ATOM 9377 OD1 ASP F 155 9.866 56.197 170.009 1.00 17.85 O +ATOM 9378 OD2 ASP F 155 10.188 58.323 170.551 1.00 24.35 O +ATOM 9379 N ILE F 156 7.063 59.164 166.821 1.00 10.88 N +ATOM 9380 CA ILE F 156 6.702 59.961 165.665 1.00 9.84 C +ATOM 9381 C ILE F 156 6.805 61.402 166.120 1.00 11.37 C +ATOM 9382 O ILE F 156 6.429 61.733 167.242 1.00 18.83 O +ATOM 9383 CB ILE F 156 5.299 59.657 165.149 1.00 8.50 C +ATOM 9384 CG1 ILE F 156 5.022 60.497 163.911 1.00 8.50 C +ATOM 9385 CG2 ILE F 156 4.265 59.959 166.202 1.00 9.01 C +ATOM 9386 CD1 ILE F 156 3.717 60.176 163.256 1.00 8.50 C +ATOM 9387 N GLY F 157 7.372 62.251 165.282 1.00 11.43 N +ATOM 9388 CA GLY F 157 7.529 63.641 165.654 1.00 10.15 C +ATOM 9389 C GLY F 157 7.826 64.500 164.453 1.00 11.09 C +ATOM 9390 O GLY F 157 7.825 64.024 163.316 1.00 12.89 O +ATOM 9391 N ASN F 158 8.090 65.772 164.715 1.00 13.77 N +ATOM 9392 CA ASN F 158 8.382 66.759 163.680 1.00 10.09 C +ATOM 9393 C ASN F 158 7.407 66.795 162.526 1.00 8.50 C +ATOM 9394 O ASN F 158 7.819 66.898 161.382 1.00 11.69 O +ATOM 9395 CB ASN F 158 9.803 66.599 163.150 1.00 13.72 C +ATOM 9396 CG ASN F 158 10.814 67.298 164.005 1.00 22.99 C +ATOM 9397 OD1 ASN F 158 11.776 66.683 164.477 1.00 22.48 O +ATOM 9398 ND2 ASN F 158 10.611 68.604 164.213 1.00 34.60 N +ATOM 9399 N VAL F 159 6.120 66.703 162.824 1.00 8.50 N +ATOM 9400 CA VAL F 159 5.128 66.740 161.770 1.00 11.71 C +ATOM 9401 C VAL F 159 4.790 68.189 161.473 1.00 11.19 C +ATOM 9402 O VAL F 159 4.593 68.983 162.388 1.00 10.29 O +ATOM 9403 CB VAL F 159 3.850 65.873 162.080 1.00 9.96 C +ATOM 9404 CG1 VAL F 159 3.874 65.348 163.490 1.00 10.36 C +ATOM 9405 CG2 VAL F 159 2.574 66.649 161.811 1.00 8.50 C +ATOM 9406 N ASN F 160 4.827 68.538 160.190 1.00 12.59 N +ATOM 9407 CA ASN F 160 4.527 69.888 159.717 1.00 14.25 C +ATOM 9408 C ASN F 160 3.755 69.716 158.407 1.00 13.83 C +ATOM 9409 O ASN F 160 3.894 68.688 157.736 1.00 12.43 O +ATOM 9410 CB ASN F 160 5.820 70.686 159.462 1.00 9.78 C +ATOM 9411 CG ASN F 160 6.614 70.922 160.706 1.00 8.50 C +ATOM 9412 OD1 ASN F 160 7.564 70.206 160.989 1.00 20.41 O +ATOM 9413 ND2 ASN F 160 6.237 71.938 161.466 1.00 21.20 N +ATOM 9414 N MET F 161 2.974 70.723 158.032 1.00 9.06 N +ATOM 9415 CA MET F 161 2.176 70.651 156.820 1.00 8.96 C +ATOM 9416 C MET F 161 1.984 72.030 156.215 1.00 13.80 C +ATOM 9417 O MET F 161 1.705 73.001 156.931 1.00 16.77 O +ATOM 9418 CB MET F 161 0.811 70.048 157.145 1.00 8.50 C +ATOM 9419 CG MET F 161 -0.104 69.871 155.969 1.00 16.21 C +ATOM 9420 SD MET F 161 -1.564 68.955 156.451 1.00 12.43 S +ATOM 9421 CE MET F 161 -2.257 68.567 154.792 1.00 9.96 C +ATOM 9422 N TRP F 162 2.159 72.118 154.901 1.00 13.70 N +ATOM 9423 CA TRP F 162 2.005 73.367 154.170 1.00 11.24 C +ATOM 9424 C TRP F 162 0.844 73.162 153.206 1.00 14.96 C +ATOM 9425 O TRP F 162 0.518 72.014 152.849 1.00 16.57 O +ATOM 9426 CB TRP F 162 3.264 73.679 153.366 1.00 8.50 C +ATOM 9427 CG TRP F 162 4.489 73.929 154.156 1.00 8.50 C +ATOM 9428 CD1 TRP F 162 5.090 75.129 154.347 1.00 17.52 C +ATOM 9429 CD2 TRP F 162 5.332 72.952 154.791 1.00 10.51 C +ATOM 9430 NE1 TRP F 162 6.263 74.972 155.051 1.00 22.84 N +ATOM 9431 CE2 TRP F 162 6.434 73.642 155.337 1.00 18.08 C +ATOM 9432 CE3 TRP F 162 5.268 71.562 154.949 1.00 14.04 C +ATOM 9433 CZ2 TRP F 162 7.468 72.983 156.034 1.00 11.90 C +ATOM 9434 CZ3 TRP F 162 6.292 70.916 155.637 1.00 8.50 C +ATOM 9435 CH2 TRP F 162 7.375 71.630 156.170 1.00 8.50 C +ATOM 9436 N ASP F 163 0.214 74.259 152.790 1.00 13.08 N +ATOM 9437 CA ASP F 163 -0.903 74.164 151.850 1.00 15.87 C +ATOM 9438 C ASP F 163 -0.452 74.316 150.389 1.00 15.82 C +ATOM 9439 O ASP F 163 -1.277 74.489 149.479 1.00 16.86 O +ATOM 9440 CB ASP F 163 -2.029 75.168 152.199 1.00 24.87 C +ATOM 9441 CG ASP F 163 -1.608 76.648 152.065 1.00 29.18 C +ATOM 9442 OD1 ASP F 163 -0.694 76.997 151.277 1.00 23.28 O +ATOM 9443 OD2 ASP F 163 -2.245 77.485 152.741 1.00 34.41 O +ATOM 9444 N PHE F 164 0.861 74.309 150.189 1.00 9.24 N +ATOM 9445 CA PHE F 164 1.443 74.438 148.864 1.00 10.19 C +ATOM 9446 C PHE F 164 2.565 73.419 148.730 1.00 12.91 C +ATOM 9447 O PHE F 164 2.928 72.768 149.713 1.00 17.91 O +ATOM 9448 CB PHE F 164 1.945 75.869 148.604 1.00 11.41 C +ATOM 9449 CG PHE F 164 3.035 76.328 149.539 1.00 13.83 C +ATOM 9450 CD1 PHE F 164 2.723 76.904 150.764 1.00 12.91 C +ATOM 9451 CD2 PHE F 164 4.373 76.198 149.188 1.00 12.58 C +ATOM 9452 CE1 PHE F 164 3.724 77.340 151.621 1.00 10.02 C +ATOM 9453 CE2 PHE F 164 5.379 76.633 150.044 1.00 11.39 C +ATOM 9454 CZ PHE F 164 5.053 77.204 151.260 1.00 9.17 C +ATOM 9455 N VAL F 165 3.119 73.276 147.527 1.00 13.51 N +ATOM 9456 CA VAL F 165 4.174 72.296 147.284 1.00 9.68 C +ATOM 9457 C VAL F 165 5.588 72.839 147.483 1.00 9.64 C +ATOM 9458 O VAL F 165 6.033 73.743 146.775 1.00 11.63 O +ATOM 9459 CB VAL F 165 4.056 71.693 145.859 1.00 11.07 C +ATOM 9460 CG1 VAL F 165 5.064 70.560 145.674 1.00 23.57 C +ATOM 9461 CG2 VAL F 165 2.650 71.186 145.595 1.00 9.86 C +ATOM 9462 N LEU F 166 6.289 72.280 148.457 1.00 10.48 N +ATOM 9463 CA LEU F 166 7.660 72.682 148.739 1.00 9.25 C +ATOM 9464 C LEU F 166 8.576 72.324 147.560 1.00 10.10 C +ATOM 9465 O LEU F 166 8.407 71.297 146.872 1.00 10.02 O +ATOM 9466 CB LEU F 166 8.171 71.994 150.012 1.00 9.98 C +ATOM 9467 CG LEU F 166 8.196 72.766 151.319 1.00 8.50 C +ATOM 9468 CD1 LEU F 166 6.856 73.416 151.534 1.00 8.97 C +ATOM 9469 CD2 LEU F 166 8.550 71.849 152.458 1.00 8.50 C +ATOM 9470 N SER F 167 9.555 73.180 147.322 1.00 11.06 N +ATOM 9471 CA SER F 167 10.497 72.941 146.245 1.00 13.77 C +ATOM 9472 C SER F 167 11.606 72.035 146.765 1.00 13.29 C +ATOM 9473 O SER F 167 11.737 71.828 147.971 1.00 19.34 O +ATOM 9474 CB SER F 167 11.079 74.276 145.741 1.00 20.48 C +ATOM 9475 OG SER F 167 11.976 74.866 146.675 1.00 33.38 O +ATOM 9476 N PRO F 168 12.422 71.484 145.864 1.00 9.06 N +ATOM 9477 CA PRO F 168 13.519 70.611 146.262 1.00 10.62 C +ATOM 9478 C PRO F 168 14.461 71.282 147.271 1.00 15.09 C +ATOM 9479 O PRO F 168 14.929 70.648 148.215 1.00 22.25 O +ATOM 9480 CB PRO F 168 14.216 70.353 144.936 1.00 12.37 C +ATOM 9481 CG PRO F 168 13.091 70.340 143.980 1.00 8.50 C +ATOM 9482 CD PRO F 168 12.305 71.529 144.398 1.00 9.80 C +ATOM 9483 N ASP F 169 14.715 72.573 147.084 1.00 16.61 N +ATOM 9484 CA ASP F 169 15.607 73.310 147.971 1.00 17.51 C +ATOM 9485 C ASP F 169 14.990 73.469 149.348 1.00 14.61 C +ATOM 9486 O ASP F 169 15.672 73.308 150.358 1.00 21.31 O +ATOM 9487 CB ASP F 169 15.956 74.683 147.372 1.00 27.06 C +ATOM 9488 CG ASP F 169 16.674 74.579 146.030 1.00 34.07 C +ATOM 9489 OD1 ASP F 169 17.816 74.053 145.996 1.00 43.92 O +ATOM 9490 OD2 ASP F 169 16.092 75.023 145.015 1.00 34.86 O +ATOM 9491 N GLU F 170 13.696 73.758 149.387 1.00 8.50 N +ATOM 9492 CA GLU F 170 13.011 73.927 150.648 1.00 8.50 C +ATOM 9493 C GLU F 170 12.974 72.564 151.346 1.00 10.46 C +ATOM 9494 O GLU F 170 13.425 72.427 152.483 1.00 14.11 O +ATOM 9495 CB GLU F 170 11.607 74.484 150.422 1.00 8.50 C +ATOM 9496 CG GLU F 170 11.575 75.769 149.614 1.00 14.79 C +ATOM 9497 CD GLU F 170 10.179 76.348 149.435 1.00 27.93 C +ATOM 9498 OE1 GLU F 170 9.588 76.774 150.451 1.00 39.46 O +ATOM 9499 OE2 GLU F 170 9.687 76.404 148.283 1.00 24.31 O +ATOM 9500 N ILE F 171 12.529 71.537 150.634 1.00 10.66 N +ATOM 9501 CA ILE F 171 12.455 70.192 151.192 1.00 10.05 C +ATOM 9502 C ILE F 171 13.800 69.794 151.744 1.00 11.67 C +ATOM 9503 O ILE F 171 13.894 69.053 152.723 1.00 11.58 O +ATOM 9504 CB ILE F 171 12.000 69.174 150.147 1.00 8.50 C +ATOM 9505 CG1 ILE F 171 10.538 69.423 149.832 1.00 8.50 C +ATOM 9506 CG2 ILE F 171 12.217 67.768 150.638 1.00 8.50 C +ATOM 9507 CD1 ILE F 171 9.943 68.488 148.855 1.00 26.22 C +ATOM 9508 N ASN F 172 14.848 70.335 151.139 1.00 16.53 N +ATOM 9509 CA ASN F 172 16.185 70.027 151.579 1.00 17.56 C +ATOM 9510 C ASN F 172 16.494 70.720 152.883 1.00 16.17 C +ATOM 9511 O ASN F 172 16.955 70.060 153.815 1.00 23.74 O +ATOM 9512 CB ASN F 172 17.215 70.397 150.535 1.00 25.35 C +ATOM 9513 CG ASN F 172 18.582 69.941 150.918 1.00 37.55 C +ATOM 9514 OD1 ASN F 172 19.419 70.741 151.337 1.00 42.78 O +ATOM 9515 ND2 ASN F 172 18.816 68.637 150.824 1.00 43.92 N +ATOM 9516 N THR F 173 16.216 72.019 152.997 1.00 9.68 N +ATOM 9517 CA THR F 173 16.504 72.690 154.266 1.00 12.41 C +ATOM 9518 C THR F 173 15.663 72.066 155.400 1.00 10.57 C +ATOM 9519 O THR F 173 16.167 71.844 156.504 1.00 11.47 O +ATOM 9520 CB THR F 173 16.318 74.246 154.230 1.00 18.07 C +ATOM 9521 OG1 THR F 173 14.965 74.589 154.566 1.00 24.68 O +ATOM 9522 CG2 THR F 173 16.681 74.825 152.863 1.00 17.24 C +ATOM 9523 N ILE F 174 14.407 71.731 155.126 1.00 8.50 N +ATOM 9524 CA ILE F 174 13.595 71.118 156.161 1.00 8.50 C +ATOM 9525 C ILE F 174 14.345 69.909 156.693 1.00 8.50 C +ATOM 9526 O ILE F 174 14.501 69.743 157.895 1.00 9.79 O +ATOM 9527 CB ILE F 174 12.199 70.664 155.643 1.00 11.64 C +ATOM 9528 CG1 ILE F 174 11.212 71.836 155.608 1.00 10.02 C +ATOM 9529 CG2 ILE F 174 11.596 69.628 156.577 1.00 11.99 C +ATOM 9530 CD1 ILE F 174 11.397 72.754 154.468 1.00 12.09 C +ATOM 9531 N TYR F 175 14.850 69.084 155.785 1.00 11.99 N +ATOM 9532 CA TYR F 175 15.576 67.878 156.177 1.00 12.90 C +ATOM 9533 C TYR F 175 16.831 68.185 156.989 1.00 18.59 C +ATOM 9534 O TYR F 175 17.048 67.610 158.053 1.00 23.51 O +ATOM 9535 CB TYR F 175 15.955 67.050 154.947 1.00 8.50 C +ATOM 9536 CG TYR F 175 16.808 65.849 155.276 1.00 11.56 C +ATOM 9537 CD1 TYR F 175 16.405 64.939 156.248 1.00 21.56 C +ATOM 9538 CD2 TYR F 175 18.026 65.623 154.627 1.00 15.54 C +ATOM 9539 CE1 TYR F 175 17.198 63.831 156.568 1.00 32.00 C +ATOM 9540 CE2 TYR F 175 18.824 64.515 154.935 1.00 20.51 C +ATOM 9541 CZ TYR F 175 18.408 63.626 155.904 1.00 29.77 C +ATOM 9542 OH TYR F 175 19.178 62.525 156.222 1.00 40.93 O +ATOM 9543 N LEU F 176 17.653 69.078 156.458 1.00 19.06 N +ATOM 9544 CA LEU F 176 18.907 69.469 157.074 1.00 20.39 C +ATOM 9545 C LEU F 176 18.786 70.286 158.349 1.00 25.75 C +ATOM 9546 O LEU F 176 19.799 70.568 159.008 1.00 25.18 O +ATOM 9547 CB LEU F 176 19.739 70.245 156.062 1.00 20.35 C +ATOM 9548 CG LEU F 176 20.937 69.503 155.487 1.00 26.80 C +ATOM 9549 CD1 LEU F 176 20.767 67.978 155.611 1.00 33.59 C +ATOM 9550 CD2 LEU F 176 21.096 69.938 154.047 1.00 37.43 C +ATOM 9551 N GLY F 177 17.562 70.685 158.681 1.00 26.78 N +ATOM 9552 CA GLY F 177 17.357 71.467 159.884 1.00 32.98 C +ATOM 9553 C GLY F 177 17.600 72.942 159.655 1.00 37.58 C +ATOM 9554 O GLY F 177 18.468 73.554 160.276 1.00 45.95 O +ATOM 9555 N GLY F 178 16.870 73.505 158.704 1.00 41.01 N +ATOM 9556 CA GLY F 178 17.001 74.919 158.426 1.00 37.89 C +ATOM 9557 C GLY F 178 15.768 75.569 159.003 1.00 37.37 C +ATOM 9558 O GLY F 178 14.979 74.902 159.682 1.00 36.52 O +ATOM 9559 N PRO F 179 15.615 76.885 158.829 1.00 35.66 N +ATOM 9560 CA PRO F 179 14.443 77.584 159.352 1.00 35.15 C +ATOM 9561 C PRO F 179 13.365 77.679 158.278 1.00 31.55 C +ATOM 9562 O PRO F 179 13.666 77.925 157.109 1.00 31.53 O +ATOM 9563 CB PRO F 179 15.006 78.945 159.717 1.00 40.26 C +ATOM 9564 CG PRO F 179 15.995 79.175 158.623 1.00 37.77 C +ATOM 9565 CD PRO F 179 16.673 77.839 158.450 1.00 36.87 C +ATOM 9566 N PHE F 180 12.115 77.479 158.684 1.00 30.02 N +ATOM 9567 CA PHE F 180 10.980 77.521 157.765 1.00 28.16 C +ATOM 9568 C PHE F 180 9.707 77.780 158.559 1.00 29.07 C +ATOM 9569 O PHE F 180 9.704 77.662 159.793 1.00 29.14 O +ATOM 9570 CB PHE F 180 10.856 76.183 157.035 1.00 32.00 C +ATOM 9571 CG PHE F 180 10.865 74.992 157.959 1.00 32.92 C +ATOM 9572 CD1 PHE F 180 12.066 74.400 158.337 1.00 38.92 C +ATOM 9573 CD2 PHE F 180 9.681 74.494 158.484 1.00 33.40 C +ATOM 9574 CE1 PHE F 180 12.090 73.330 159.230 1.00 37.02 C +ATOM 9575 CE2 PHE F 180 9.692 73.431 159.372 1.00 38.06 C +ATOM 9576 CZ PHE F 180 10.902 72.846 159.747 1.00 40.52 C +ATOM 9577 N SER F 181 8.629 78.104 157.848 1.00 27.96 N +ATOM 9578 CA SER F 181 7.343 78.379 158.485 1.00 31.89 C +ATOM 9579 C SER F 181 6.158 77.672 157.818 1.00 30.94 C +ATOM 9580 O SER F 181 5.703 78.076 156.735 1.00 38.35 O +ATOM 9581 CB SER F 181 7.071 79.890 158.548 1.00 35.06 C +ATOM 9582 OG SER F 181 7.087 80.362 159.894 1.00 52.76 O +ATOM 9583 N PRO F 182 5.674 76.575 158.433 1.00 22.09 N +ATOM 9584 CA PRO F 182 4.540 75.813 157.912 1.00 20.94 C +ATOM 9585 C PRO F 182 3.322 76.716 158.000 1.00 23.01 C +ATOM 9586 O PRO F 182 3.337 77.693 158.747 1.00 27.07 O +ATOM 9587 CB PRO F 182 4.417 74.676 158.919 1.00 21.42 C +ATOM 9588 CG PRO F 182 5.796 74.560 159.499 1.00 15.56 C +ATOM 9589 CD PRO F 182 6.194 75.960 159.666 1.00 11.48 C +ATOM 9590 N ASN F 183 2.263 76.401 157.268 1.00 21.87 N +ATOM 9591 CA ASN F 183 1.075 77.236 157.340 1.00 16.78 C +ATOM 9592 C ASN F 183 -0.238 76.459 157.490 1.00 18.96 C +ATOM 9593 O ASN F 183 -1.313 76.960 157.125 1.00 27.71 O +ATOM 9594 CB ASN F 183 1.019 78.229 156.174 1.00 8.50 C +ATOM 9595 CG ASN F 183 0.748 77.573 154.854 1.00 8.50 C +ATOM 9596 OD1 ASN F 183 0.828 76.359 154.708 1.00 16.21 O +ATOM 9597 ND2 ASN F 183 0.444 78.380 153.867 1.00 8.50 N +ATOM 9598 N VAL F 184 -0.143 75.232 158.007 1.00 12.64 N +ATOM 9599 CA VAL F 184 -1.314 74.396 158.249 1.00 13.05 C +ATOM 9600 C VAL F 184 -1.044 73.719 159.589 1.00 15.76 C +ATOM 9601 O VAL F 184 -1.726 73.998 160.583 1.00 22.02 O +ATOM 9602 CB VAL F 184 -1.546 73.328 157.146 1.00 14.94 C +ATOM 9603 CG1 VAL F 184 -2.736 72.453 157.509 1.00 8.69 C +ATOM 9604 CG2 VAL F 184 -1.797 73.987 155.806 1.00 10.00 C +ATOM 9605 N LEU F 185 -0.024 72.864 159.626 1.00 13.37 N +ATOM 9606 CA LEU F 185 0.350 72.167 160.858 1.00 13.66 C +ATOM 9607 C LEU F 185 1.745 72.661 161.163 1.00 16.37 C +ATOM 9608 O LEU F 185 2.595 72.664 160.268 1.00 16.78 O +ATOM 9609 CB LEU F 185 0.354 70.648 160.669 1.00 9.02 C +ATOM 9610 CG LEU F 185 -0.722 69.862 161.406 1.00 8.50 C +ATOM 9611 CD1 LEU F 185 -2.048 70.479 161.153 1.00 8.50 C +ATOM 9612 CD2 LEU F 185 -0.745 68.446 160.954 1.00 8.50 C +ATOM 9613 N ASN F 186 1.962 73.122 162.398 1.00 19.48 N +ATOM 9614 CA ASN F 186 3.263 73.654 162.815 1.00 15.24 C +ATOM 9615 C ASN F 186 3.711 72.982 164.097 1.00 16.94 C +ATOM 9616 O ASN F 186 3.103 73.178 165.140 1.00 22.63 O +ATOM 9617 CB ASN F 186 3.155 75.162 163.043 1.00 16.06 C +ATOM 9618 CG ASN F 186 4.494 75.811 163.284 1.00 13.12 C +ATOM 9619 OD1 ASN F 186 5.424 75.178 163.768 1.00 10.11 O +ATOM 9620 ND2 ASN F 186 4.598 77.087 162.940 1.00 20.93 N +ATOM 9621 N TRP F 187 4.793 72.212 164.026 1.00 16.41 N +ATOM 9622 CA TRP F 187 5.311 71.490 165.193 1.00 14.48 C +ATOM 9623 C TRP F 187 5.760 72.436 166.317 1.00 14.75 C +ATOM 9624 O TRP F 187 5.870 72.034 167.473 1.00 16.31 O +ATOM 9625 CB TRP F 187 6.470 70.567 164.764 1.00 13.11 C +ATOM 9626 CG TRP F 187 6.823 69.507 165.760 1.00 10.09 C +ATOM 9627 CD1 TRP F 187 7.985 69.407 166.472 1.00 8.51 C +ATOM 9628 CD2 TRP F 187 6.016 68.387 166.145 1.00 8.50 C +ATOM 9629 NE1 TRP F 187 7.951 68.293 167.277 1.00 8.50 N +ATOM 9630 CE2 TRP F 187 6.758 67.647 167.096 1.00 8.50 C +ATOM 9631 CE3 TRP F 187 4.743 67.937 165.782 1.00 8.50 C +ATOM 9632 CZ2 TRP F 187 6.269 66.478 167.686 1.00 10.19 C +ATOM 9633 CZ3 TRP F 187 4.257 66.774 166.370 1.00 13.40 C +ATOM 9634 CH2 TRP F 187 5.021 66.057 167.313 1.00 8.50 C +ATOM 9635 N ARG F 188 6.009 73.693 165.965 1.00 15.11 N +ATOM 9636 CA ARG F 188 6.456 74.710 166.912 1.00 23.21 C +ATOM 9637 C ARG F 188 5.260 75.341 167.660 1.00 26.67 C +ATOM 9638 O ARG F 188 5.408 75.923 168.741 1.00 31.52 O +ATOM 9639 CB ARG F 188 7.245 75.763 166.095 1.00 29.84 C +ATOM 9640 CG ARG F 188 7.928 76.900 166.860 1.00 66.48 C +ATOM 9641 CD ARG F 188 6.946 77.967 167.451 1.00 86.87 C +ATOM 9642 NE ARG F 188 6.236 78.795 166.465 1.00 89.28 N +ATOM 9643 CZ ARG F 188 5.150 79.523 166.732 1.00 84.06 C +ATOM 9644 NH1 ARG F 188 4.624 79.530 167.957 1.00 87.35 N +ATOM 9645 NH2 ARG F 188 4.604 80.270 165.777 1.00 78.36 N +ATOM 9646 N ALA F 189 4.076 75.214 167.075 1.00 24.85 N +ATOM 9647 CA ALA F 189 2.855 75.757 167.659 1.00 21.36 C +ATOM 9648 C ALA F 189 1.775 74.712 167.406 1.00 20.98 C +ATOM 9649 O ALA F 189 0.768 74.974 166.744 1.00 25.30 O +ATOM 9650 CB ALA F 189 2.498 77.074 166.982 1.00 21.26 C +ATOM 9651 N LEU F 190 2.017 73.511 167.907 1.00 17.10 N +ATOM 9652 CA LEU F 190 1.095 72.406 167.705 1.00 23.40 C +ATOM 9653 C LEU F 190 -0.071 72.483 168.687 1.00 25.09 C +ATOM 9654 O LEU F 190 0.101 72.879 169.843 1.00 25.45 O +ATOM 9655 CB LEU F 190 1.837 71.055 167.846 1.00 20.52 C +ATOM 9656 CG LEU F 190 1.135 69.837 167.232 1.00 14.36 C +ATOM 9657 CD1 LEU F 190 1.323 69.828 165.728 1.00 8.50 C +ATOM 9658 CD2 LEU F 190 1.672 68.570 167.832 1.00 18.19 C +ATOM 9659 N LYS F 191 -1.265 72.170 168.201 1.00 29.32 N +ATOM 9660 CA LYS F 191 -2.461 72.167 169.021 1.00 27.02 C +ATOM 9661 C LYS F 191 -2.979 70.742 168.871 1.00 24.15 C +ATOM 9662 O LYS F 191 -3.532 70.367 167.843 1.00 21.90 O +ATOM 9663 CB LYS F 191 -3.456 73.196 168.486 1.00 36.67 C +ATOM 9664 CG LYS F 191 -4.423 73.736 169.535 1.00 61.28 C +ATOM 9665 CD LYS F 191 -5.056 75.054 169.081 1.00 80.81 C +ATOM 9666 CE LYS F 191 -5.956 75.665 170.159 1.00 90.98 C +ATOM 9667 NZ LYS F 191 -6.433 77.043 169.809 1.00 90.91 N +ATOM 9668 N TYR F 192 -2.750 69.932 169.889 1.00 24.42 N +ATOM 9669 CA TYR F 192 -3.141 68.534 169.829 1.00 27.90 C +ATOM 9670 C TYR F 192 -3.920 68.064 171.055 1.00 32.96 C +ATOM 9671 O TYR F 192 -4.106 68.810 172.022 1.00 39.89 O +ATOM 9672 CB TYR F 192 -1.882 67.679 169.674 1.00 19.81 C +ATOM 9673 CG TYR F 192 -0.946 67.799 170.851 1.00 15.52 C +ATOM 9674 CD1 TYR F 192 -0.161 68.938 171.026 1.00 17.40 C +ATOM 9675 CD2 TYR F 192 -0.861 66.784 171.806 1.00 13.36 C +ATOM 9676 CE1 TYR F 192 0.693 69.073 172.128 1.00 19.57 C +ATOM 9677 CE2 TYR F 192 -0.013 66.901 172.911 1.00 20.40 C +ATOM 9678 CZ TYR F 192 0.765 68.056 173.070 1.00 26.26 C +ATOM 9679 OH TYR F 192 1.593 68.193 174.179 1.00 26.93 O +ATOM 9680 N GLU F 193 -4.312 66.796 171.020 1.00 33.69 N +ATOM 9681 CA GLU F 193 -5.052 66.169 172.098 1.00 38.25 C +ATOM 9682 C GLU F 193 -4.609 64.704 172.117 1.00 38.60 C +ATOM 9683 O GLU F 193 -4.709 63.998 171.102 1.00 39.86 O +ATOM 9684 CB GLU F 193 -6.554 66.286 171.823 1.00 49.44 C +ATOM 9685 CG GLU F 193 -7.458 66.031 173.017 1.00 65.17 C +ATOM 9686 CD GLU F 193 -8.915 66.215 172.663 1.00 75.15 C +ATOM 9687 OE1 GLU F 193 -9.531 65.248 172.168 1.00 84.38 O +ATOM 9688 OE2 GLU F 193 -9.439 67.331 172.859 1.00 82.93 O +ATOM 9689 N VAL F 194 -4.063 64.272 173.249 1.00 36.39 N +ATOM 9690 CA VAL F 194 -3.580 62.904 173.410 1.00 34.92 C +ATOM 9691 C VAL F 194 -4.694 62.005 173.937 1.00 36.50 C +ATOM 9692 O VAL F 194 -5.578 62.464 174.668 1.00 39.35 O +ATOM 9693 CB VAL F 194 -2.383 62.870 174.379 1.00 36.70 C +ATOM 9694 CG1 VAL F 194 -1.964 61.438 174.675 1.00 34.34 C +ATOM 9695 CG2 VAL F 194 -1.225 63.652 173.786 1.00 44.00 C +ATOM 9696 N GLN F 195 -4.647 60.731 173.562 1.00 35.05 N +ATOM 9697 CA GLN F 195 -5.650 59.784 174.000 1.00 34.34 C +ATOM 9698 C GLN F 195 -5.019 58.408 174.134 1.00 29.23 C +ATOM 9699 O GLN F 195 -4.467 57.869 173.177 1.00 31.26 O +ATOM 9700 CB GLN F 195 -6.799 59.727 172.982 1.00 49.44 C +ATOM 9701 CG GLN F 195 -8.155 59.381 173.582 1.00 66.08 C +ATOM 9702 CD GLN F 195 -8.661 60.483 174.487 1.00 76.45 C +ATOM 9703 OE1 GLN F 195 -8.832 60.285 175.694 1.00 86.93 O +ATOM 9704 NE2 GLN F 195 -8.891 61.660 173.913 1.00 77.63 N +ATOM 9705 N GLY F 196 -5.072 57.848 175.332 1.00 25.96 N +ATOM 9706 CA GLY F 196 -4.527 56.520 175.524 1.00 27.37 C +ATOM 9707 C GLY F 196 -3.106 56.473 176.031 1.00 29.51 C +ATOM 9708 O GLY F 196 -2.626 57.396 176.695 1.00 36.55 O +ATOM 9709 N GLU F 197 -2.430 55.384 175.699 1.00 26.39 N +ATOM 9710 CA GLU F 197 -1.060 55.148 176.130 1.00 22.82 C +ATOM 9711 C GLU F 197 -0.015 55.827 175.247 1.00 25.10 C +ATOM 9712 O GLU F 197 0.712 55.143 174.506 1.00 34.75 O +ATOM 9713 CB GLU F 197 -0.798 53.637 176.156 1.00 22.28 C +ATOM 9714 CG GLU F 197 0.459 53.235 176.905 1.00 32.32 C +ATOM 9715 CD GLU F 197 0.222 52.987 178.394 1.00 43.88 C +ATOM 9716 OE1 GLU F 197 -0.756 53.530 178.969 1.00 43.78 O +ATOM 9717 OE2 GLU F 197 1.030 52.237 178.988 1.00 46.94 O +ATOM 9718 N VAL F 198 0.045 57.154 175.283 1.00 17.45 N +ATOM 9719 CA VAL F 198 1.034 57.882 174.485 1.00 13.85 C +ATOM 9720 C VAL F 198 1.699 58.932 175.370 1.00 17.72 C +ATOM 9721 O VAL F 198 1.023 59.645 176.122 1.00 23.34 O +ATOM 9722 CB VAL F 198 0.423 58.495 173.185 1.00 15.20 C +ATOM 9723 CG1 VAL F 198 -1.105 58.428 173.206 1.00 11.43 C +ATOM 9724 CG2 VAL F 198 0.905 59.931 172.975 1.00 14.86 C +ATOM 9725 N PHE F 199 3.029 58.975 175.318 1.00 14.22 N +ATOM 9726 CA PHE F 199 3.813 59.904 176.128 1.00 13.68 C +ATOM 9727 C PHE F 199 4.622 60.847 175.266 1.00 14.42 C +ATOM 9728 O PHE F 199 4.852 60.578 174.090 1.00 21.36 O +ATOM 9729 CB PHE F 199 4.782 59.136 177.020 1.00 14.88 C +ATOM 9730 CG PHE F 199 4.154 57.987 177.747 1.00 22.90 C +ATOM 9731 CD1 PHE F 199 4.038 56.737 177.140 1.00 21.41 C +ATOM 9732 CD2 PHE F 199 3.673 58.152 179.042 1.00 31.79 C +ATOM 9733 CE1 PHE F 199 3.452 55.669 177.811 1.00 26.44 C +ATOM 9734 CE2 PHE F 199 3.084 57.090 179.729 1.00 31.31 C +ATOM 9735 CZ PHE F 199 2.972 55.844 179.111 1.00 32.40 C +ATOM 9736 N THR F 200 5.085 61.931 175.872 1.00 12.05 N +ATOM 9737 CA THR F 200 5.895 62.932 175.188 1.00 13.71 C +ATOM 9738 C THR F 200 7.298 62.833 175.772 1.00 14.94 C +ATOM 9739 O THR F 200 7.490 63.102 176.963 1.00 24.76 O +ATOM 9740 CB THR F 200 5.336 64.371 175.422 1.00 16.15 C +ATOM 9741 OG1 THR F 200 3.967 64.436 174.986 1.00 26.72 O +ATOM 9742 CG2 THR F 200 6.148 65.389 174.646 1.00 16.28 C +ATOM 9743 N LYS F 201 8.258 62.399 174.957 1.00 13.92 N +ATOM 9744 CA LYS F 201 9.651 62.254 175.392 1.00 12.39 C +ATOM 9745 C LYS F 201 10.604 62.957 174.406 1.00 13.94 C +ATOM 9746 O LYS F 201 10.188 63.400 173.324 1.00 14.16 O +ATOM 9747 CB LYS F 201 10.016 60.767 175.526 1.00 12.08 C +ATOM 9748 CG LYS F 201 9.286 60.011 176.638 1.00 14.91 C +ATOM 9749 CD LYS F 201 9.449 60.715 177.985 1.00 25.83 C +ATOM 9750 CE LYS F 201 9.313 59.751 179.159 1.00 32.27 C +ATOM 9751 NZ LYS F 201 10.489 58.815 179.218 1.00 28.72 N +ATOM 9752 N PRO F 202 11.881 63.120 174.789 1.00 11.71 N +ATOM 9753 CA PRO F 202 12.862 63.775 173.919 1.00 11.92 C +ATOM 9754 C PRO F 202 13.089 62.921 172.673 1.00 13.44 C +ATOM 9755 O PRO F 202 13.233 61.714 172.789 1.00 17.70 O +ATOM 9756 CB PRO F 202 14.116 63.791 174.794 1.00 17.09 C +ATOM 9757 CG PRO F 202 13.582 63.793 176.174 1.00 11.63 C +ATOM 9758 CD PRO F 202 12.481 62.790 176.088 1.00 8.50 C +ATOM 9759 N GLN F 203 13.169 63.541 171.502 1.00 11.65 N +ATOM 9760 CA GLN F 203 13.368 62.801 170.262 1.00 9.28 C +ATOM 9761 C GLN F 203 14.712 62.107 170.180 1.00 11.88 C +ATOM 9762 O GLN F 203 15.737 62.668 170.607 1.00 11.33 O +ATOM 9763 CB GLN F 203 13.214 63.725 169.069 1.00 18.39 C +ATOM 9764 CG GLN F 203 14.194 64.875 169.037 1.00 13.12 C +ATOM 9765 CD GLN F 203 14.007 65.714 167.800 1.00 23.75 C +ATOM 9766 OE1 GLN F 203 14.973 66.047 167.118 1.00 35.12 O +ATOM 9767 NE2 GLN F 203 12.753 66.053 167.489 1.00 21.70 N +ATOM 9768 N LEU F 204 14.698 60.906 169.586 1.00 12.22 N +ATOM 9769 CA LEU F 204 15.908 60.095 169.445 1.00 10.76 C +ATOM 9770 C LEU F 204 16.717 60.448 168.221 1.00 12.25 C +ATOM 9771 O LEU F 204 17.930 60.204 168.186 1.00 15.45 O +ATOM 9772 CB LEU F 204 15.572 58.621 169.422 1.00 10.30 C +ATOM 9773 CG LEU F 204 14.705 58.210 170.584 1.00 9.99 C +ATOM 9774 CD1 LEU F 204 13.263 58.226 170.101 1.00 17.53 C +ATOM 9775 CD2 LEU F 204 15.117 56.839 171.051 1.00 18.84 C +ATOM 9776 N TRP F 205 16.034 60.926 167.185 1.00 13.28 N +ATOM 9777 CA TRP F 205 16.720 61.335 165.971 1.00 19.75 C +ATOM 9778 C TRP F 205 17.283 62.715 166.263 1.00 26.21 C +ATOM 9779 O TRP F 205 16.743 63.432 167.102 1.00 34.07 O +ATOM 9780 CB TRP F 205 15.771 61.390 164.779 1.00 17.09 C +ATOM 9781 CG TRP F 205 14.466 62.004 165.081 1.00 9.96 C +ATOM 9782 CD1 TRP F 205 14.149 63.325 165.036 1.00 10.53 C +ATOM 9783 CD2 TRP F 205 13.272 61.312 165.443 1.00 13.44 C +ATOM 9784 NE1 TRP F 205 12.822 63.501 165.342 1.00 16.99 N +ATOM 9785 CE2 TRP F 205 12.260 62.277 165.594 1.00 13.83 C +ATOM 9786 CE3 TRP F 205 12.959 59.964 165.652 1.00 16.47 C +ATOM 9787 CZ2 TRP F 205 10.952 61.937 165.943 1.00 16.90 C +ATOM 9788 CZ3 TRP F 205 11.655 59.628 166.000 1.00 18.93 C +ATOM 9789 CH2 TRP F 205 10.671 60.611 166.142 1.00 15.59 C +ATOM 9790 N PRO F 206 18.419 63.064 165.637 1.00 29.90 N +ATOM 9791 CA PRO F 206 19.058 64.366 165.840 1.00 30.99 C +ATOM 9792 C PRO F 206 18.393 65.493 165.044 1.00 36.78 C +ATOM 9793 O PRO F 206 18.450 66.643 165.536 1.00 41.59 O +ATOM 9794 CB PRO F 206 20.486 64.107 165.372 1.00 31.61 C +ATOM 9795 CG PRO F 206 20.271 63.165 164.230 1.00 34.76 C +ATOM 9796 CD PRO F 206 19.256 62.196 164.782 1.00 35.74 C +ATOM 9797 OXT PRO F 206 17.837 65.223 163.947 1.00 41.13 O +TER 9798 PRO F 206 +ATOM 9799 N GLN G 1 36.484 52.287 196.751 1.00 60.48 N +ATOM 9800 CA GLN G 1 36.788 53.701 196.404 1.00 53.67 C +ATOM 9801 C GLN G 1 38.069 53.688 195.579 1.00 52.44 C +ATOM 9802 O GLN G 1 39.115 54.182 195.991 1.00 58.14 O +ATOM 9803 CB GLN G 1 36.928 54.573 197.658 1.00 56.76 C +ATOM 9804 CG GLN G 1 36.667 56.058 197.421 1.00 45.07 C +ATOM 9805 CD GLN G 1 37.628 56.674 196.425 1.00 45.41 C +ATOM 9806 OE1 GLN G 1 38.844 56.628 196.605 1.00 37.32 O +ATOM 9807 NE2 GLN G 1 37.086 57.236 195.356 1.00 53.18 N +ATOM 9808 N THR G 2 37.977 53.084 194.408 1.00 44.05 N +ATOM 9809 CA THR G 2 39.130 52.996 193.538 1.00 37.56 C +ATOM 9810 C THR G 2 38.783 53.686 192.228 1.00 37.06 C +ATOM 9811 O THR G 2 37.640 53.581 191.757 1.00 40.99 O +ATOM 9812 CB THR G 2 39.476 51.529 193.262 1.00 35.14 C +ATOM 9813 OG1 THR G 2 39.502 50.804 194.498 1.00 42.18 O +ATOM 9814 CG2 THR G 2 40.824 51.422 192.582 1.00 41.73 C +ATOM 9815 N ASP G 3 39.736 54.442 191.678 1.00 32.98 N +ATOM 9816 CA ASP G 3 39.511 55.112 190.407 1.00 25.65 C +ATOM 9817 C ASP G 3 39.840 54.093 189.326 1.00 26.22 C +ATOM 9818 O ASP G 3 41.011 53.870 188.993 1.00 23.34 O +ATOM 9819 CB ASP G 3 40.399 56.340 190.273 1.00 32.92 C +ATOM 9820 CG ASP G 3 39.900 57.289 189.197 1.00 40.33 C +ATOM 9821 OD1 ASP G 3 39.012 56.874 188.411 1.00 32.08 O +ATOM 9822 OD2 ASP G 3 40.380 58.450 189.149 1.00 46.09 O +ATOM 9823 N MET G 4 38.790 53.452 188.817 1.00 24.56 N +ATOM 9824 CA MET G 4 38.936 52.420 187.797 1.00 21.32 C +ATOM 9825 C MET G 4 39.118 52.973 186.395 1.00 18.62 C +ATOM 9826 O MET G 4 39.020 52.222 185.418 1.00 15.39 O +ATOM 9827 CB MET G 4 37.747 51.456 187.829 1.00 16.68 C +ATOM 9828 CG MET G 4 37.753 50.534 189.012 1.00 11.60 C +ATOM 9829 SD MET G 4 39.280 49.597 189.022 1.00 26.89 S +ATOM 9830 CE MET G 4 38.890 48.279 187.933 1.00 9.86 C +ATOM 9831 N SER G 5 39.423 54.270 186.307 1.00 15.69 N +ATOM 9832 CA SER G 5 39.629 54.945 185.027 1.00 16.25 C +ATOM 9833 C SER G 5 40.684 54.288 184.154 1.00 18.83 C +ATOM 9834 O SER G 5 41.779 53.969 184.639 1.00 26.91 O +ATOM 9835 CB SER G 5 40.018 56.412 185.248 1.00 15.12 C +ATOM 9836 OG SER G 5 38.886 57.194 185.598 1.00 28.16 O +ATOM 9837 N ARG G 6 40.350 54.106 182.870 1.00 15.75 N +ATOM 9838 CA ARG G 6 41.263 53.513 181.890 1.00 15.92 C +ATOM 9839 C ARG G 6 41.539 52.035 182.146 1.00 17.44 C +ATOM 9840 O ARG G 6 42.442 51.453 181.527 1.00 22.56 O +ATOM 9841 CB ARG G 6 42.617 54.269 181.874 1.00 43.10 C +ATOM 9842 CG ARG G 6 42.849 55.238 180.704 1.00 54.78 C +ATOM 9843 CD ARG G 6 42.855 54.515 179.352 1.00 64.18 C +ATOM 9844 NE ARG G 6 41.739 54.948 178.516 1.00 62.17 N +ATOM 9845 CZ ARG G 6 41.702 56.118 177.891 1.00 63.46 C +ATOM 9846 NH1 ARG G 6 42.733 56.950 178.003 1.00 63.48 N +ATOM 9847 NH2 ARG G 6 40.619 56.484 177.213 1.00 57.78 N +ATOM 9848 N LYS G 7 40.757 51.421 183.030 1.00 16.41 N +ATOM 9849 CA LYS G 7 40.938 50.008 183.361 1.00 13.60 C +ATOM 9850 C LYS G 7 39.707 49.178 183.044 1.00 11.07 C +ATOM 9851 O LYS G 7 38.614 49.723 182.819 1.00 8.50 O +ATOM 9852 CB LYS G 7 41.336 49.858 184.832 1.00 21.02 C +ATOM 9853 CG LYS G 7 42.750 50.363 185.122 1.00 27.37 C +ATOM 9854 CD LYS G 7 42.961 50.636 186.597 1.00 37.58 C +ATOM 9855 CE LYS G 7 44.349 51.204 186.850 1.00 44.88 C +ATOM 9856 NZ LYS G 7 44.455 51.693 188.249 1.00 64.68 N +ATOM 9857 N ALA G 8 39.902 47.865 182.985 1.00 8.73 N +ATOM 9858 CA ALA G 8 38.825 46.942 182.682 1.00 8.80 C +ATOM 9859 C ALA G 8 39.099 45.653 183.423 1.00 9.00 C +ATOM 9860 O ALA G 8 40.259 45.318 183.677 1.00 8.50 O +ATOM 9861 CB ALA G 8 38.774 46.673 181.178 1.00 9.74 C +ATOM 9862 N PHE G 9 38.033 44.966 183.824 1.00 9.64 N +ATOM 9863 CA PHE G 9 38.166 43.687 184.499 1.00 8.50 C +ATOM 9864 C PHE G 9 38.224 42.694 183.351 1.00 11.66 C +ATOM 9865 O PHE G 9 37.453 42.811 182.392 1.00 11.77 O +ATOM 9866 CB PHE G 9 36.929 43.377 185.334 1.00 9.78 C +ATOM 9867 CG PHE G 9 36.768 44.244 186.554 1.00 15.02 C +ATOM 9868 CD1 PHE G 9 37.747 44.279 187.542 1.00 16.66 C +ATOM 9869 CD2 PHE G 9 35.600 44.987 186.743 1.00 13.18 C +ATOM 9870 CE1 PHE G 9 37.562 45.043 188.703 1.00 14.10 C +ATOM 9871 CE2 PHE G 9 35.409 45.749 187.896 1.00 8.50 C +ATOM 9872 CZ PHE G 9 36.390 45.774 188.873 1.00 10.12 C +ATOM 9873 N VAL G 10 39.137 41.733 183.427 1.00 12.91 N +ATOM 9874 CA VAL G 10 39.263 40.736 182.371 1.00 13.00 C +ATOM 9875 C VAL G 10 39.190 39.280 182.882 1.00 12.26 C +ATOM 9876 O VAL G 10 39.957 38.868 183.757 1.00 9.71 O +ATOM 9877 CB VAL G 10 40.531 41.015 181.485 1.00 12.46 C +ATOM 9878 CG1 VAL G 10 41.628 41.681 182.290 1.00 8.50 C +ATOM 9879 CG2 VAL G 10 41.031 39.732 180.834 1.00 12.03 C +ATOM 9880 N PHE G 11 38.195 38.547 182.377 1.00 13.78 N +ATOM 9881 CA PHE G 11 37.941 37.131 182.711 1.00 12.08 C +ATOM 9882 C PHE G 11 38.483 36.321 181.523 1.00 14.78 C +ATOM 9883 O PHE G 11 37.765 36.067 180.537 1.00 13.87 O +ATOM 9884 CB PHE G 11 36.428 36.886 182.844 1.00 15.35 C +ATOM 9885 CG PHE G 11 35.731 37.846 183.781 1.00 25.06 C +ATOM 9886 CD1 PHE G 11 35.625 37.557 185.140 1.00 24.17 C +ATOM 9887 CD2 PHE G 11 35.189 39.052 183.310 1.00 20.02 C +ATOM 9888 CE1 PHE G 11 34.989 38.455 186.019 1.00 22.48 C +ATOM 9889 CE2 PHE G 11 34.557 39.945 184.180 1.00 11.67 C +ATOM 9890 CZ PHE G 11 34.456 39.648 185.534 1.00 13.47 C +ATOM 9891 N PRO G 12 39.752 35.883 181.613 1.00 14.22 N +ATOM 9892 CA PRO G 12 40.453 35.113 180.577 1.00 13.59 C +ATOM 9893 C PRO G 12 39.896 33.755 180.192 1.00 20.73 C +ATOM 9894 O PRO G 12 40.089 33.317 179.056 1.00 27.15 O +ATOM 9895 CB PRO G 12 41.870 34.981 181.147 1.00 9.85 C +ATOM 9896 CG PRO G 12 41.973 36.119 182.112 1.00 9.37 C +ATOM 9897 CD PRO G 12 40.632 36.094 182.772 1.00 12.68 C +ATOM 9898 N LYS G 13 39.291 33.047 181.141 1.00 29.51 N +ATOM 9899 CA LYS G 13 38.754 31.727 180.819 1.00 36.45 C +ATOM 9900 C LYS G 13 37.397 31.398 181.422 1.00 36.27 C +ATOM 9901 O LYS G 13 36.977 32.006 182.424 1.00 30.89 O +ATOM 9902 CB LYS G 13 39.776 30.606 181.099 1.00 40.21 C +ATOM 9903 CG LYS G 13 40.514 30.672 182.430 1.00 45.23 C +ATOM 9904 CD LYS G 13 41.620 29.611 182.449 1.00 53.11 C +ATOM 9905 CE LYS G 13 42.534 29.713 183.673 1.00 61.94 C +ATOM 9906 NZ LYS G 13 41.826 29.436 184.963 1.00 73.06 N +ATOM 9907 N GLU G 14 36.714 30.450 180.770 1.00 36.98 N +ATOM 9908 CA GLU G 14 35.387 30.011 181.184 1.00 42.93 C +ATOM 9909 C GLU G 14 35.444 29.451 182.599 1.00 46.03 C +ATOM 9910 O GLU G 14 36.183 28.493 182.885 1.00 47.90 O +ATOM 9911 CB GLU G 14 34.816 28.972 180.209 1.00 39.60 C +ATOM 9912 CG GLU G 14 33.345 28.632 180.481 1.00 46.43 C +ATOM 9913 CD GLU G 14 32.759 27.683 179.456 1.00 54.71 C +ATOM 9914 OE1 GLU G 14 32.662 28.070 178.269 1.00 63.34 O +ATOM 9915 OE2 GLU G 14 32.390 26.551 179.832 1.00 56.32 O +ATOM 9916 N SER G 15 34.682 30.073 183.491 1.00 47.91 N +ATOM 9917 CA SER G 15 34.669 29.647 184.879 1.00 45.44 C +ATOM 9918 C SER G 15 33.279 29.477 185.455 1.00 43.70 C +ATOM 9919 O SER G 15 32.257 29.767 184.826 1.00 38.62 O +ATOM 9920 CB SER G 15 35.514 30.602 185.754 1.00 49.87 C +ATOM 9921 OG SER G 15 35.154 31.967 185.555 1.00 58.92 O +ATOM 9922 N ASP G 16 33.285 28.955 186.667 1.00 47.41 N +ATOM 9923 CA ASP G 16 32.097 28.674 187.445 1.00 47.95 C +ATOM 9924 C ASP G 16 32.266 29.519 188.712 1.00 44.03 C +ATOM 9925 O ASP G 16 31.301 29.813 189.416 1.00 42.80 O +ATOM 9926 CB ASP G 16 32.158 27.178 187.815 1.00 59.39 C +ATOM 9927 CG ASP G 16 30.803 26.573 188.116 1.00 71.12 C +ATOM 9928 OD1 ASP G 16 29.774 27.111 187.643 1.00 82.70 O +ATOM 9929 OD2 ASP G 16 30.781 25.528 188.809 1.00 70.60 O +ATOM 9930 N THR G 17 33.506 29.960 188.931 1.00 41.35 N +ATOM 9931 CA THR G 17 33.913 30.708 190.112 1.00 40.33 C +ATOM 9932 C THR G 17 34.312 32.191 190.004 1.00 40.58 C +ATOM 9933 O THR G 17 34.330 32.896 191.021 1.00 41.26 O +ATOM 9934 CB THR G 17 35.095 29.962 190.760 1.00 42.77 C +ATOM 9935 OG1 THR G 17 36.094 29.680 189.765 1.00 35.43 O +ATOM 9936 CG2 THR G 17 34.621 28.647 191.346 1.00 49.98 C +ATOM 9937 N SER G 18 34.677 32.653 188.808 1.00 36.69 N +ATOM 9938 CA SER G 18 35.109 34.043 188.636 1.00 24.59 C +ATOM 9939 C SER G 18 33.968 35.053 188.492 1.00 22.57 C +ATOM 9940 O SER G 18 33.002 34.818 187.748 1.00 20.65 O +ATOM 9941 CB SER G 18 36.055 34.163 187.445 1.00 21.22 C +ATOM 9942 OG SER G 18 37.147 33.272 187.567 1.00 12.97 O +ATOM 9943 N TYR G 19 34.088 36.161 189.223 1.00 13.02 N +ATOM 9944 CA TYR G 19 33.112 37.235 189.192 1.00 11.77 C +ATOM 9945 C TYR G 19 33.609 38.411 190.024 1.00 14.34 C +ATOM 9946 O TYR G 19 34.555 38.278 190.804 1.00 10.38 O +ATOM 9947 CB TYR G 19 31.741 36.774 189.707 1.00 16.59 C +ATOM 9948 CG TYR G 19 31.666 36.469 191.194 1.00 29.81 C +ATOM 9949 CD1 TYR G 19 31.371 37.473 192.119 1.00 35.87 C +ATOM 9950 CD2 TYR G 19 31.864 35.171 191.676 1.00 32.14 C +ATOM 9951 CE1 TYR G 19 31.275 37.197 193.479 1.00 39.95 C +ATOM 9952 CE2 TYR G 19 31.768 34.882 193.037 1.00 31.56 C +ATOM 9953 CZ TYR G 19 31.471 35.901 193.928 1.00 36.40 C +ATOM 9954 OH TYR G 19 31.365 35.632 195.270 1.00 44.45 O +ATOM 9955 N VAL G 20 32.973 39.569 189.835 1.00 18.09 N +ATOM 9956 CA VAL G 20 33.305 40.786 190.569 1.00 12.05 C +ATOM 9957 C VAL G 20 32.011 41.330 191.130 1.00 14.66 C +ATOM 9958 O VAL G 20 31.038 41.507 190.401 1.00 11.43 O +ATOM 9959 CB VAL G 20 33.908 41.860 189.675 1.00 16.17 C +ATOM 9960 CG1 VAL G 20 34.144 43.135 190.483 1.00 16.15 C +ATOM 9961 CG2 VAL G 20 35.216 41.364 189.081 1.00 15.52 C +ATOM 9962 N SER G 21 31.997 41.535 192.440 1.00 20.14 N +ATOM 9963 CA SER G 21 30.833 42.053 193.129 1.00 20.33 C +ATOM 9964 C SER G 21 30.965 43.568 193.286 1.00 16.58 C +ATOM 9965 O SER G 21 32.007 44.083 193.713 1.00 14.04 O +ATOM 9966 CB SER G 21 30.693 41.381 194.501 1.00 30.75 C +ATOM 9967 OG SER G 21 29.534 41.836 195.191 1.00 48.11 O +ATOM 9968 N LEU G 22 29.907 44.271 192.908 1.00 12.30 N +ATOM 9969 CA LEU G 22 29.876 45.717 193.001 1.00 13.98 C +ATOM 9970 C LEU G 22 28.986 46.112 194.168 1.00 21.35 C +ATOM 9971 O LEU G 22 27.856 45.620 194.297 1.00 25.18 O +ATOM 9972 CB LEU G 22 29.338 46.307 191.698 1.00 13.11 C +ATOM 9973 CG LEU G 22 30.339 46.795 190.650 1.00 9.55 C +ATOM 9974 CD1 LEU G 22 31.561 45.897 190.538 1.00 8.50 C +ATOM 9975 CD2 LEU G 22 29.598 46.896 189.329 1.00 13.24 C +ATOM 9976 N LYS G 23 29.509 46.978 195.029 1.00 26.39 N +ATOM 9977 CA LYS G 23 28.769 47.434 196.196 1.00 32.60 C +ATOM 9978 C LYS G 23 28.198 48.835 195.987 1.00 37.16 C +ATOM 9979 O LYS G 23 28.930 49.820 195.816 1.00 36.14 O +ATOM 9980 CB LYS G 23 29.627 47.336 197.468 1.00 47.88 C +ATOM 9981 CG LYS G 23 29.911 45.893 197.956 1.00 63.14 C +ATOM 9982 CD LYS G 23 30.882 45.853 199.166 1.00 72.75 C +ATOM 9983 CE LYS G 23 32.379 45.926 198.779 1.00 66.28 C +ATOM 9984 NZ LYS G 23 32.907 44.619 198.261 1.00 60.96 N +ATOM 9985 N ALA G 24 26.872 48.904 195.969 1.00 46.93 N +ATOM 9986 CA ALA G 24 26.168 50.167 195.784 1.00 56.29 C +ATOM 9987 C ALA G 24 25.513 50.569 197.098 1.00 65.87 C +ATOM 9988 O ALA G 24 24.868 49.748 197.753 1.00 72.50 O +ATOM 9989 CB ALA G 24 25.111 50.020 194.707 1.00 58.71 C +ATOM 9990 N PRO G 25 25.716 51.819 197.530 1.00 72.88 N +ATOM 9991 CA PRO G 25 25.134 52.320 198.779 1.00 78.23 C +ATOM 9992 C PRO G 25 23.715 52.828 198.546 1.00 79.56 C +ATOM 9993 O PRO G 25 23.427 54.024 198.668 1.00 78.44 O +ATOM 9994 CB PRO G 25 26.082 53.449 199.160 1.00 84.23 C +ATOM 9995 CG PRO G 25 26.472 54.011 197.827 1.00 79.84 C +ATOM 9996 CD PRO G 25 26.697 52.776 196.979 1.00 75.44 C +ATOM 9997 N LEU G 26 22.833 51.899 198.213 1.00 80.91 N +ATOM 9998 CA LEU G 26 21.449 52.229 197.934 1.00 83.87 C +ATOM 9999 C LEU G 26 20.577 52.213 199.195 1.00 85.94 C +ATOM 10000 O LEU G 26 20.706 51.331 200.052 1.00 84.50 O +ATOM 10001 CB LEU G 26 20.906 51.272 196.866 1.00 83.53 C +ATOM 10002 CG LEU G 26 20.129 51.874 195.689 1.00 77.07 C +ATOM 10003 CD1 LEU G 26 20.726 53.210 195.255 1.00 74.60 C +ATOM 10004 CD2 LEU G 26 20.136 50.873 194.546 1.00 69.74 C +ATOM 10005 N THR G 27 19.713 53.220 199.301 1.00 88.67 N +ATOM 10006 CA THR G 27 18.803 53.375 200.434 1.00 88.03 C +ATOM 10007 C THR G 27 17.348 53.352 199.969 1.00 81.96 C +ATOM 10008 O THR G 27 16.506 52.678 200.567 1.00 81.73 O +ATOM 10009 CB THR G 27 19.065 54.708 201.183 1.00 92.51 C +ATOM 10010 OG1 THR G 27 19.106 55.792 200.242 1.00 93.30 O +ATOM 10011 CG2 THR G 27 20.388 54.642 201.958 1.00 95.09 C +ATOM 10012 N LYS G 28 17.059 54.131 198.928 1.00 75.77 N +ATOM 10013 CA LYS G 28 15.716 54.213 198.357 1.00 70.45 C +ATOM 10014 C LYS G 28 15.581 53.199 197.232 1.00 61.33 C +ATOM 10015 O LYS G 28 16.555 52.920 196.528 1.00 67.15 O +ATOM 10016 CB LYS G 28 15.461 55.613 197.778 1.00 76.18 C +ATOM 10017 CG LYS G 28 15.123 56.692 198.795 1.00 89.37 C +ATOM 10018 CD LYS G 28 13.684 56.575 199.280 1.00 96.78 C +ATOM 10019 CE LYS G 28 13.327 57.699 200.248 1.00104.24 C +ATOM 10020 NZ LYS G 28 11.892 57.637 200.667 1.00107.89 N +ATOM 10021 N PRO G 29 14.403 52.566 197.106 1.00 50.09 N +ATOM 10022 CA PRO G 29 14.183 51.586 196.037 1.00 46.26 C +ATOM 10023 C PRO G 29 14.067 52.329 194.680 1.00 42.00 C +ATOM 10024 O PRO G 29 13.557 53.470 194.621 1.00 40.69 O +ATOM 10025 CB PRO G 29 12.867 50.909 196.463 1.00 47.00 C +ATOM 10026 CG PRO G 29 12.150 51.972 197.209 1.00 46.84 C +ATOM 10027 CD PRO G 29 13.269 52.568 198.047 1.00 51.54 C +ATOM 10028 N LEU G 30 14.541 51.696 193.604 1.00 31.90 N +ATOM 10029 CA LEU G 30 14.523 52.324 192.283 1.00 23.69 C +ATOM 10030 C LEU G 30 13.172 52.387 191.556 1.00 22.49 C +ATOM 10031 O LEU G 30 12.469 51.374 191.411 1.00 16.27 O +ATOM 10032 CB LEU G 30 15.562 51.672 191.360 1.00 21.28 C +ATOM 10033 CG LEU G 30 17.072 51.784 191.619 1.00 13.13 C +ATOM 10034 CD1 LEU G 30 17.383 52.935 192.556 1.00 9.13 C +ATOM 10035 CD2 LEU G 30 17.587 50.490 192.182 1.00 10.20 C +ATOM 10036 N LYS G 31 12.851 53.587 191.062 1.00 21.01 N +ATOM 10037 CA LYS G 31 11.625 53.852 190.300 1.00 20.29 C +ATOM 10038 C LYS G 31 11.973 54.116 188.830 1.00 19.63 C +ATOM 10039 O LYS G 31 11.084 54.349 187.991 1.00 14.24 O +ATOM 10040 CB LYS G 31 10.896 55.066 190.880 1.00 30.41 C +ATOM 10041 CG LYS G 31 10.077 54.769 192.135 1.00 52.63 C +ATOM 10042 CD LYS G 31 8.880 53.864 191.813 1.00 65.77 C +ATOM 10043 CE LYS G 31 8.100 53.464 193.064 1.00 70.81 C +ATOM 10044 NZ LYS G 31 6.944 52.579 192.725 1.00 76.36 N +ATOM 10045 N ALA G 32 13.280 54.107 188.556 1.00 20.56 N +ATOM 10046 CA ALA G 32 13.861 54.321 187.235 1.00 13.18 C +ATOM 10047 C ALA G 32 15.358 54.108 187.384 1.00 10.05 C +ATOM 10048 O ALA G 32 15.859 54.064 188.501 1.00 12.93 O +ATOM 10049 CB ALA G 32 13.585 55.727 186.764 1.00 8.50 C +ATOM 10050 N PHE G 33 16.068 53.949 186.274 1.00 10.08 N +ATOM 10051 CA PHE G 33 17.519 53.766 186.326 1.00 10.68 C +ATOM 10052 C PHE G 33 18.116 53.757 184.923 1.00 14.08 C +ATOM 10053 O PHE G 33 17.391 53.607 183.938 1.00 17.26 O +ATOM 10054 CB PHE G 33 17.886 52.461 187.055 1.00 14.45 C +ATOM 10055 CG PHE G 33 17.399 51.199 186.358 1.00 18.59 C +ATOM 10056 CD1 PHE G 33 18.199 50.553 185.424 1.00 17.25 C +ATOM 10057 CD2 PHE G 33 16.163 50.641 186.664 1.00 16.65 C +ATOM 10058 CE1 PHE G 33 17.782 49.380 184.809 1.00 8.50 C +ATOM 10059 CE2 PHE G 33 15.744 49.465 186.051 1.00 13.42 C +ATOM 10060 CZ PHE G 33 16.561 48.842 185.124 1.00 14.47 C +ATOM 10061 N THR G 34 19.424 53.971 184.842 1.00 12.22 N +ATOM 10062 CA THR G 34 20.153 53.956 183.579 1.00 11.08 C +ATOM 10063 C THR G 34 21.468 53.304 183.938 1.00 11.68 C +ATOM 10064 O THR G 34 22.113 53.699 184.915 1.00 8.50 O +ATOM 10065 CB THR G 34 20.501 55.371 183.050 1.00 16.12 C +ATOM 10066 OG1 THR G 34 19.307 56.148 182.910 1.00 21.33 O +ATOM 10067 CG2 THR G 34 21.197 55.287 181.692 1.00 9.54 C +ATOM 10068 N VAL G 35 21.835 52.271 183.191 1.00 11.98 N +ATOM 10069 CA VAL G 35 23.098 51.598 183.425 1.00 12.45 C +ATOM 10070 C VAL G 35 23.814 51.487 182.086 1.00 11.62 C +ATOM 10071 O VAL G 35 23.223 51.070 181.095 1.00 10.70 O +ATOM 10072 CB VAL G 35 22.924 50.219 184.132 1.00 11.54 C +ATOM 10073 CG1 VAL G 35 21.521 49.715 183.993 1.00 8.50 C +ATOM 10074 CG2 VAL G 35 23.930 49.210 183.583 1.00 13.47 C +ATOM 10075 N CYS G 36 25.047 51.978 182.057 1.00 12.53 N +ATOM 10076 CA CYS G 36 25.877 51.967 180.863 1.00 10.89 C +ATOM 10077 C CYS G 36 27.137 51.167 181.168 1.00 9.14 C +ATOM 10078 O CYS G 36 27.573 51.123 182.312 1.00 11.82 O +ATOM 10079 CB CYS G 36 26.271 53.393 180.493 1.00 8.50 C +ATOM 10080 SG CYS G 36 24.882 54.471 180.118 1.00 10.06 S +ATOM 10081 N LEU G 37 27.690 50.507 180.159 1.00 8.50 N +ATOM 10082 CA LEU G 37 28.902 49.728 180.334 1.00 9.08 C +ATOM 10083 C LEU G 37 29.542 49.400 178.989 1.00 9.79 C +ATOM 10084 O LEU G 37 28.920 49.562 177.938 1.00 8.55 O +ATOM 10085 CB LEU G 37 28.620 48.452 181.137 1.00 17.62 C +ATOM 10086 CG LEU G 37 27.613 47.411 180.620 1.00 17.49 C +ATOM 10087 CD1 LEU G 37 28.321 46.397 179.738 1.00 18.43 C +ATOM 10088 CD2 LEU G 37 26.994 46.692 181.788 1.00 8.50 C +ATOM 10089 N HIS G 38 30.793 48.963 179.040 1.00 8.50 N +ATOM 10090 CA HIS G 38 31.565 48.621 177.860 1.00 11.13 C +ATOM 10091 C HIS G 38 31.971 47.166 178.038 1.00 14.61 C +ATOM 10092 O HIS G 38 32.452 46.795 179.112 1.00 21.49 O +ATOM 10093 CB HIS G 38 32.847 49.464 177.861 1.00 20.08 C +ATOM 10094 CG HIS G 38 33.011 50.357 176.669 1.00 24.52 C +ATOM 10095 ND1 HIS G 38 33.122 51.729 176.781 1.00 17.89 N +ATOM 10096 CD2 HIS G 38 33.163 50.072 175.352 1.00 20.08 C +ATOM 10097 CE1 HIS G 38 33.340 52.249 175.587 1.00 19.36 C +ATOM 10098 NE2 HIS G 38 33.370 51.265 174.704 1.00 23.79 N +ATOM 10099 N PHE G 39 31.779 46.332 177.027 1.00 9.77 N +ATOM 10100 CA PHE G 39 32.199 44.950 177.161 1.00 9.90 C +ATOM 10101 C PHE G 39 32.797 44.503 175.850 1.00 9.62 C +ATOM 10102 O PHE G 39 32.568 45.124 174.824 1.00 12.79 O +ATOM 10103 CB PHE G 39 31.046 44.043 177.616 1.00 13.02 C +ATOM 10104 CG PHE G 39 30.002 43.778 176.561 1.00 10.77 C +ATOM 10105 CD1 PHE G 39 28.937 44.654 176.379 1.00 8.50 C +ATOM 10106 CD2 PHE G 39 30.070 42.627 175.782 1.00 8.50 C +ATOM 10107 CE1 PHE G 39 27.958 44.390 175.447 1.00 8.50 C +ATOM 10108 CE2 PHE G 39 29.102 42.356 174.848 1.00 10.01 C +ATOM 10109 CZ PHE G 39 28.037 43.241 174.676 1.00 8.81 C +ATOM 10110 N TYR G 40 33.589 43.448 175.887 1.00 8.50 N +ATOM 10111 CA TYR G 40 34.226 42.960 174.687 1.00 9.09 C +ATOM 10112 C TYR G 40 34.457 41.461 174.825 1.00 11.55 C +ATOM 10113 O TYR G 40 35.339 41.039 175.568 1.00 10.31 O +ATOM 10114 CB TYR G 40 35.556 43.691 174.501 1.00 8.50 C +ATOM 10115 CG TYR G 40 36.329 43.287 173.265 1.00 9.56 C +ATOM 10116 CD1 TYR G 40 35.673 42.761 172.154 1.00 15.39 C +ATOM 10117 CD2 TYR G 40 37.713 43.434 173.199 1.00 8.50 C +ATOM 10118 CE1 TYR G 40 36.367 42.391 171.014 1.00 9.96 C +ATOM 10119 CE2 TYR G 40 38.417 43.068 172.054 1.00 10.28 C +ATOM 10120 CZ TYR G 40 37.729 42.549 170.970 1.00 8.50 C +ATOM 10121 OH TYR G 40 38.374 42.211 169.819 1.00 9.55 O +ATOM 10122 N THR G 41 33.683 40.665 174.087 1.00 14.62 N +ATOM 10123 CA THR G 41 33.799 39.210 174.143 1.00 14.07 C +ATOM 10124 C THR G 41 33.681 38.545 172.770 1.00 17.94 C +ATOM 10125 O THR G 41 33.222 39.161 171.807 1.00 18.80 O +ATOM 10126 CB THR G 41 32.727 38.595 175.085 1.00 21.78 C +ATOM 10127 OG1 THR G 41 32.934 37.174 175.189 1.00 23.52 O +ATOM 10128 CG2 THR G 41 31.314 38.866 174.547 1.00 11.18 C +ATOM 10129 N GLU G 42 34.036 37.264 172.710 1.00 22.16 N +ATOM 10130 CA GLU G 42 33.991 36.515 171.464 1.00 26.42 C +ATOM 10131 C GLU G 42 32.936 35.406 171.515 1.00 26.74 C +ATOM 10132 O GLU G 42 32.867 34.557 170.635 1.00 35.70 O +ATOM 10133 CB GLU G 42 35.381 35.915 171.231 1.00 33.23 C +ATOM 10134 CG GLU G 42 35.851 35.919 169.780 1.00 50.80 C +ATOM 10135 CD GLU G 42 37.353 35.673 169.656 1.00 53.43 C +ATOM 10136 OE1 GLU G 42 37.778 34.492 169.595 1.00 57.48 O +ATOM 10137 OE2 GLU G 42 38.107 36.667 169.638 1.00 46.50 O +ATOM 10138 N LEU G 43 32.212 35.334 172.626 1.00 20.51 N +ATOM 10139 CA LEU G 43 31.203 34.296 172.836 1.00 16.66 C +ATOM 10140 C LEU G 43 29.975 34.429 171.972 1.00 19.13 C +ATOM 10141 O LEU G 43 29.386 33.426 171.623 1.00 25.15 O +ATOM 10142 CB LEU G 43 30.746 34.277 174.302 1.00 23.81 C +ATOM 10143 CG LEU G 43 31.436 33.493 175.427 1.00 24.31 C +ATOM 10144 CD1 LEU G 43 32.927 33.289 175.193 1.00 20.46 C +ATOM 10145 CD2 LEU G 43 31.182 34.240 176.738 1.00 22.66 C +ATOM 10146 N SER G 44 29.571 35.665 171.680 1.00 23.00 N +ATOM 10147 CA SER G 44 28.381 35.986 170.893 1.00 21.54 C +ATOM 10148 C SER G 44 27.956 34.965 169.823 1.00 30.43 C +ATOM 10149 O SER G 44 26.748 34.734 169.617 1.00 25.67 O +ATOM 10150 CB SER G 44 28.590 37.347 170.227 1.00 26.59 C +ATOM 10151 OG SER G 44 29.082 38.317 171.131 1.00 31.29 O +ATOM 10152 N SER G 45 28.950 34.361 169.162 1.00 36.69 N +ATOM 10153 CA SER G 45 28.739 33.391 168.085 1.00 42.84 C +ATOM 10154 C SER G 45 28.502 31.935 168.501 1.00 41.78 C +ATOM 10155 O SER G 45 28.109 31.119 167.662 1.00 48.79 O +ATOM 10156 CB SER G 45 29.921 33.437 167.105 1.00 51.07 C +ATOM 10157 OG SER G 45 30.275 34.772 166.768 1.00 65.56 O +ATOM 10158 N THR G 46 28.757 31.598 169.765 1.00 33.77 N +ATOM 10159 CA THR G 46 28.575 30.231 170.237 1.00 26.55 C +ATOM 10160 C THR G 46 27.579 30.027 171.388 1.00 26.29 C +ATOM 10161 O THR G 46 26.734 29.142 171.321 1.00 39.38 O +ATOM 10162 CB THR G 46 29.937 29.573 170.583 1.00 26.83 C +ATOM 10163 OG1 THR G 46 30.336 29.933 171.909 1.00 19.98 O +ATOM 10164 CG2 THR G 46 31.028 30.031 169.587 1.00 26.82 C +ATOM 10165 N ARG G 47 27.665 30.818 172.447 1.00 23.37 N +ATOM 10166 CA ARG G 47 26.735 30.654 173.574 1.00 21.68 C +ATOM 10167 C ARG G 47 26.203 31.975 174.116 1.00 19.89 C +ATOM 10168 O ARG G 47 26.553 33.038 173.609 1.00 26.23 O +ATOM 10169 CB ARG G 47 27.373 29.846 174.722 1.00 22.91 C +ATOM 10170 CG ARG G 47 28.464 30.563 175.520 1.00 18.80 C +ATOM 10171 CD ARG G 47 29.008 29.636 176.589 1.00 14.80 C +ATOM 10172 NE ARG G 47 30.121 30.203 177.350 1.00 13.18 N +ATOM 10173 CZ ARG G 47 29.987 31.033 178.391 1.00 19.61 C +ATOM 10174 NH1 ARG G 47 28.783 31.416 178.792 1.00 21.12 N +ATOM 10175 NH2 ARG G 47 31.054 31.415 179.094 1.00 19.52 N +ATOM 10176 N GLY G 48 25.313 31.897 175.104 1.00 18.78 N +ATOM 10177 CA GLY G 48 24.746 33.092 175.705 1.00 14.79 C +ATOM 10178 C GLY G 48 25.625 33.441 176.886 1.00 18.08 C +ATOM 10179 O GLY G 48 26.441 32.600 177.292 1.00 22.30 O +ATOM 10180 N TYR G 49 25.486 34.654 177.432 1.00 14.97 N +ATOM 10181 CA TYR G 49 26.297 35.064 178.585 1.00 15.65 C +ATOM 10182 C TYR G 49 25.680 36.237 179.322 1.00 13.83 C +ATOM 10183 O TYR G 49 24.907 37.000 178.750 1.00 13.55 O +ATOM 10184 CB TYR G 49 27.728 35.401 178.152 1.00 18.06 C +ATOM 10185 CG TYR G 49 27.783 36.371 176.988 1.00 28.82 C +ATOM 10186 CD1 TYR G 49 27.586 37.745 177.179 1.00 28.58 C +ATOM 10187 CD2 TYR G 49 28.034 35.918 175.696 1.00 27.69 C +ATOM 10188 CE1 TYR G 49 27.644 38.641 176.109 1.00 28.51 C +ATOM 10189 CE2 TYR G 49 28.090 36.803 174.618 1.00 32.33 C +ATOM 10190 CZ TYR G 49 27.898 38.164 174.828 1.00 31.46 C +ATOM 10191 OH TYR G 49 27.984 39.037 173.754 1.00 27.14 O +ATOM 10192 N SER G 50 26.032 36.373 180.595 1.00 17.77 N +ATOM 10193 CA SER G 50 25.508 37.448 181.421 1.00 23.10 C +ATOM 10194 C SER G 50 26.431 38.662 181.412 1.00 25.83 C +ATOM 10195 O SER G 50 27.647 38.554 181.674 1.00 31.38 O +ATOM 10196 CB SER G 50 25.305 36.958 182.860 1.00 28.68 C +ATOM 10197 OG SER G 50 24.869 38.017 183.706 1.00 44.29 O +ATOM 10198 N ILE G 51 25.844 39.818 181.123 1.00 22.29 N +ATOM 10199 CA ILE G 51 26.593 41.070 181.090 1.00 16.92 C +ATOM 10200 C ILE G 51 26.503 41.805 182.432 1.00 18.48 C +ATOM 10201 O ILE G 51 27.530 42.094 183.056 1.00 21.11 O +ATOM 10202 CB ILE G 51 26.089 41.969 179.960 1.00 13.07 C +ATOM 10203 CG1 ILE G 51 26.288 41.260 178.622 1.00 19.95 C +ATOM 10204 CG2 ILE G 51 26.825 43.275 179.955 1.00 11.71 C +ATOM 10205 CD1 ILE G 51 25.656 41.982 177.442 1.00 16.13 C +ATOM 10206 N PHE G 52 25.277 42.043 182.896 1.00 14.57 N +ATOM 10207 CA PHE G 52 25.040 42.739 184.153 1.00 12.13 C +ATOM 10208 C PHE G 52 23.919 42.008 184.918 1.00 20.16 C +ATOM 10209 O PHE G 52 22.810 41.837 184.369 1.00 16.57 O +ATOM 10210 CB PHE G 52 24.609 44.167 183.841 1.00 8.50 C +ATOM 10211 CG PHE G 52 24.511 45.059 185.048 1.00 11.80 C +ATOM 10212 CD1 PHE G 52 25.663 45.540 185.674 1.00 12.46 C +ATOM 10213 CD2 PHE G 52 23.265 45.467 185.527 1.00 8.50 C +ATOM 10214 CE1 PHE G 52 25.573 46.421 186.752 1.00 8.50 C +ATOM 10215 CE2 PHE G 52 23.169 46.337 186.599 1.00 8.50 C +ATOM 10216 CZ PHE G 52 24.327 46.818 187.213 1.00 8.50 C +ATOM 10217 N SER G 53 24.199 41.589 186.166 1.00 23.54 N +ATOM 10218 CA SER G 53 23.210 40.881 187.016 1.00 19.00 C +ATOM 10219 C SER G 53 22.929 41.574 188.368 1.00 14.69 C +ATOM 10220 O SER G 53 23.765 41.542 189.286 1.00 11.79 O +ATOM 10221 CB SER G 53 23.667 39.441 187.279 1.00 25.33 C +ATOM 10222 OG SER G 53 22.625 38.671 187.883 1.00 30.47 O +ATOM 10223 N TYR G 54 21.750 42.183 188.479 1.00 13.97 N +ATOM 10224 CA TYR G 54 21.326 42.895 189.690 1.00 16.53 C +ATOM 10225 C TYR G 54 20.261 42.020 190.344 1.00 24.34 C +ATOM 10226 O TYR G 54 19.127 41.912 189.837 1.00 24.85 O +ATOM 10227 CB TYR G 54 20.725 44.249 189.296 1.00 15.76 C +ATOM 10228 CG TYR G 54 20.352 45.172 190.433 1.00 15.21 C +ATOM 10229 CD1 TYR G 54 19.091 45.087 191.054 1.00 21.45 C +ATOM 10230 CD2 TYR G 54 21.207 46.189 190.825 1.00 9.00 C +ATOM 10231 CE1 TYR G 54 18.689 46.000 192.028 1.00 8.50 C +ATOM 10232 CE2 TYR G 54 20.819 47.105 191.789 1.00 20.55 C +ATOM 10233 CZ TYR G 54 19.558 47.004 192.384 1.00 17.89 C +ATOM 10234 OH TYR G 54 19.178 47.920 193.327 1.00 20.91 O +ATOM 10235 N ALA G 55 20.612 41.418 191.480 1.00 32.85 N +ATOM 10236 CA ALA G 55 19.698 40.516 192.188 1.00 35.07 C +ATOM 10237 C ALA G 55 19.282 40.947 193.587 1.00 34.80 C +ATOM 10238 O ALA G 55 20.061 41.574 194.314 1.00 32.08 O +ATOM 10239 CB ALA G 55 20.304 39.113 192.248 1.00 32.19 C +ATOM 10240 N THR G 56 18.061 40.558 193.954 1.00 36.98 N +ATOM 10241 CA THR G 56 17.480 40.837 195.269 1.00 43.02 C +ATOM 10242 C THR G 56 17.214 39.479 195.936 1.00 48.77 C +ATOM 10243 O THR G 56 17.223 38.432 195.268 1.00 46.67 O +ATOM 10244 CB THR G 56 16.097 41.535 195.179 1.00 36.71 C +ATOM 10245 OG1 THR G 56 16.127 42.522 194.153 1.00 48.72 O +ATOM 10246 CG2 THR G 56 15.746 42.211 196.509 1.00 45.86 C +ATOM 10247 N LYS G 57 16.970 39.508 197.248 1.00 53.60 N +ATOM 10248 CA LYS G 57 16.661 38.306 198.021 1.00 53.12 C +ATOM 10249 C LYS G 57 15.371 37.689 197.455 1.00 50.80 C +ATOM 10250 O LYS G 57 15.275 36.482 197.232 1.00 54.09 O +ATOM 10251 CB LYS G 57 16.392 38.724 199.474 1.00 62.27 C +ATOM 10252 CG LYS G 57 17.342 38.188 200.522 1.00 67.17 C +ATOM 10253 CD LYS G 57 16.951 38.728 201.911 1.00 77.93 C +ATOM 10254 CE LYS G 57 15.449 38.539 202.228 1.00 74.09 C +ATOM 10255 NZ LYS G 57 15.050 39.043 203.591 1.00 65.69 N +ATOM 10256 N ARG G 58 14.405 38.564 197.202 1.00 46.77 N +ATOM 10257 CA ARG G 58 13.083 38.222 196.691 1.00 47.74 C +ATOM 10258 C ARG G 58 13.079 37.821 195.203 1.00 45.45 C +ATOM 10259 O ARG G 58 12.369 36.898 194.787 1.00 41.48 O +ATOM 10260 CB ARG G 58 12.236 39.497 196.850 1.00 65.03 C +ATOM 10261 CG ARG G 58 10.737 39.363 197.111 1.00 67.61 C +ATOM 10262 CD ARG G 58 9.976 40.716 196.826 1.00 95.38 C +ATOM 10263 NE ARG G 58 10.345 41.867 197.678 1.00109.89 N +ATOM 10264 CZ ARG G 58 9.555 42.917 197.955 1.00109.46 C +ATOM 10265 NH1 ARG G 58 8.318 43.006 197.463 1.00 97.09 N +ATOM 10266 NH2 ARG G 58 10.010 43.897 198.735 1.00111.34 N +ATOM 10267 N GLN G 59 13.850 38.556 194.404 1.00 44.68 N +ATOM 10268 CA GLN G 59 13.917 38.337 192.957 1.00 34.96 C +ATOM 10269 C GLN G 59 15.376 38.280 192.504 1.00 31.03 C +ATOM 10270 O GLN G 59 16.090 39.279 192.580 1.00 32.96 O +ATOM 10271 CB GLN G 59 13.166 39.481 192.256 1.00 31.22 C +ATOM 10272 CG GLN G 59 13.301 39.536 190.753 1.00 28.75 C +ATOM 10273 CD GLN G 59 12.818 38.278 190.075 1.00 30.57 C +ATOM 10274 OE1 GLN G 59 13.565 37.313 189.937 1.00 34.48 O +ATOM 10275 NE2 GLN G 59 11.576 38.295 189.612 1.00 30.20 N +ATOM 10276 N ASP G 60 15.806 37.109 192.035 1.00 30.07 N +ATOM 10277 CA ASP G 60 17.186 36.904 191.585 1.00 29.69 C +ATOM 10278 C ASP G 60 17.533 37.659 190.307 1.00 27.87 C +ATOM 10279 O ASP G 60 18.707 37.984 190.068 1.00 31.04 O +ATOM 10280 CB ASP G 60 17.500 35.411 191.414 1.00 36.35 C +ATOM 10281 CG ASP G 60 16.618 34.731 190.368 1.00 40.97 C +ATOM 10282 OD1 ASP G 60 15.375 34.827 190.452 1.00 50.50 O +ATOM 10283 OD2 ASP G 60 17.171 34.071 189.467 1.00 43.54 O +ATOM 10284 N ASN G 61 16.528 37.936 189.482 1.00 19.93 N +ATOM 10285 CA ASN G 61 16.763 38.669 188.247 1.00 14.22 C +ATOM 10286 C ASN G 61 16.006 39.986 188.279 1.00 13.53 C +ATOM 10287 O ASN G 61 15.076 40.192 187.484 1.00 15.03 O +ATOM 10288 CB ASN G 61 16.340 37.823 187.045 1.00 16.35 C +ATOM 10289 CG ASN G 61 17.225 36.595 186.852 1.00 32.56 C +ATOM 10290 OD1 ASN G 61 16.790 35.596 186.268 1.00 41.42 O +ATOM 10291 ND2 ASN G 61 18.468 36.655 187.352 1.00 31.65 N +ATOM 10292 N GLU G 62 16.392 40.862 189.214 1.00 9.33 N +ATOM 10293 CA GLU G 62 15.737 42.161 189.375 1.00 12.43 C +ATOM 10294 C GLU G 62 15.938 43.038 188.135 1.00 15.59 C +ATOM 10295 O GLU G 62 15.017 43.716 187.661 1.00 16.74 O +ATOM 10296 CB GLU G 62 16.240 42.862 190.636 1.00 8.50 C +ATOM 10297 CG GLU G 62 15.360 44.024 191.098 1.00 13.94 C +ATOM 10298 CD GLU G 62 13.951 43.597 191.549 1.00 25.27 C +ATOM 10299 OE1 GLU G 62 13.223 42.947 190.756 1.00 20.28 O +ATOM 10300 OE2 GLU G 62 13.566 43.932 192.698 1.00 33.59 O +ATOM 10301 N ILE G 63 17.173 43.076 187.663 1.00 17.13 N +ATOM 10302 CA ILE G 63 17.524 43.797 186.449 1.00 13.33 C +ATOM 10303 C ILE G 63 18.714 43.002 185.913 1.00 11.32 C +ATOM 10304 O ILE G 63 19.687 42.747 186.638 1.00 10.65 O +ATOM 10305 CB ILE G 63 17.815 45.346 186.679 1.00 18.64 C +ATOM 10306 CG1 ILE G 63 19.080 45.783 185.948 1.00 20.77 C +ATOM 10307 CG2 ILE G 63 17.840 45.750 188.135 1.00 9.08 C +ATOM 10308 CD1 ILE G 63 18.887 45.861 184.447 1.00 27.87 C +ATOM 10309 N LEU G 64 18.581 42.514 184.687 1.00 8.50 N +ATOM 10310 CA LEU G 64 19.626 41.711 184.073 1.00 11.83 C +ATOM 10311 C LEU G 64 19.779 41.961 182.572 1.00 16.97 C +ATOM 10312 O LEU G 64 18.786 41.993 181.831 1.00 13.78 O +ATOM 10313 CB LEU G 64 19.333 40.225 184.322 1.00 19.08 C +ATOM 10314 CG LEU G 64 20.129 39.149 183.555 1.00 18.75 C +ATOM 10315 CD1 LEU G 64 21.030 38.356 184.467 1.00 8.92 C +ATOM 10316 CD2 LEU G 64 19.155 38.221 182.858 1.00 18.29 C +ATOM 10317 N ILE G 65 21.028 42.161 182.143 1.00 15.62 N +ATOM 10318 CA ILE G 65 21.353 42.379 180.734 1.00 12.83 C +ATOM 10319 C ILE G 65 22.073 41.112 180.291 1.00 13.91 C +ATOM 10320 O ILE G 65 23.110 40.736 180.859 1.00 12.58 O +ATOM 10321 CB ILE G 65 22.258 43.595 180.557 1.00 17.32 C +ATOM 10322 CG1 ILE G 65 21.545 44.840 181.107 1.00 9.04 C +ATOM 10323 CG2 ILE G 65 22.624 43.754 179.075 1.00 9.61 C +ATOM 10324 CD1 ILE G 65 22.433 46.044 181.240 1.00 8.50 C +ATOM 10325 N PHE G 66 21.549 40.480 179.252 1.00 12.55 N +ATOM 10326 CA PHE G 66 22.089 39.216 178.786 1.00 15.39 C +ATOM 10327 C PHE G 66 22.121 39.128 177.266 1.00 14.41 C +ATOM 10328 O PHE G 66 21.271 39.705 176.593 1.00 13.88 O +ATOM 10329 CB PHE G 66 21.144 38.122 179.322 1.00 30.48 C +ATOM 10330 CG PHE G 66 21.667 36.713 179.186 1.00 40.34 C +ATOM 10331 CD1 PHE G 66 21.391 35.962 178.055 1.00 43.48 C +ATOM 10332 CD2 PHE G 66 22.393 36.123 180.217 1.00 39.60 C +ATOM 10333 CE1 PHE G 66 21.828 34.644 177.953 1.00 47.68 C +ATOM 10334 CE2 PHE G 66 22.828 34.813 180.120 1.00 35.58 C +ATOM 10335 CZ PHE G 66 22.544 34.074 178.988 1.00 43.85 C +ATOM 10336 N TRP G 67 23.069 38.371 176.725 1.00 14.53 N +ATOM 10337 CA TRP G 67 23.130 38.169 175.280 1.00 20.07 C +ATOM 10338 C TRP G 67 22.698 36.734 175.030 1.00 24.40 C +ATOM 10339 O TRP G 67 23.417 35.800 175.428 1.00 29.73 O +ATOM 10340 CB TRP G 67 24.553 38.338 174.746 1.00 23.40 C +ATOM 10341 CG TRP G 67 24.717 37.815 173.325 1.00 29.90 C +ATOM 10342 CD1 TRP G 67 25.185 36.573 172.941 1.00 26.96 C +ATOM 10343 CD2 TRP G 67 24.395 38.511 172.111 1.00 27.43 C +ATOM 10344 NE1 TRP G 67 25.166 36.461 171.568 1.00 21.07 N +ATOM 10345 CE2 TRP G 67 24.687 37.632 171.035 1.00 32.29 C +ATOM 10346 CE3 TRP G 67 23.896 39.789 171.826 1.00 10.23 C +ATOM 10347 CZ2 TRP G 67 24.491 38.005 169.699 1.00 28.13 C +ATOM 10348 CZ3 TRP G 67 23.711 40.154 170.505 1.00 14.28 C +ATOM 10349 CH2 TRP G 67 24.006 39.265 169.456 1.00 18.79 C +ATOM 10350 N SER G 68 21.531 36.547 174.412 1.00 21.83 N +ATOM 10351 CA SER G 68 21.068 35.195 174.118 1.00 18.96 C +ATOM 10352 C SER G 68 21.412 34.819 172.681 1.00 20.19 C +ATOM 10353 O SER G 68 20.925 35.419 171.702 1.00 12.75 O +ATOM 10354 CB SER G 68 19.575 35.010 174.420 1.00 18.19 C +ATOM 10355 OG SER G 68 18.741 35.746 173.551 1.00 32.03 O +ATOM 10356 N LYS G 69 22.315 33.849 172.586 1.00 23.92 N +ATOM 10357 CA LYS G 69 22.822 33.329 171.324 1.00 28.46 C +ATOM 10358 C LYS G 69 21.748 33.287 170.232 1.00 27.24 C +ATOM 10359 O LYS G 69 20.612 32.875 170.482 1.00 28.14 O +ATOM 10360 CB LYS G 69 23.400 31.930 171.583 1.00 36.64 C +ATOM 10361 CG LYS G 69 24.487 31.436 170.618 1.00 49.25 C +ATOM 10362 CD LYS G 69 23.913 30.968 169.281 1.00 55.96 C +ATOM 10363 CE LYS G 69 24.851 30.002 168.561 1.00 56.28 C +ATOM 10364 NZ LYS G 69 24.839 28.646 169.177 1.00 46.37 N +ATOM 10365 N ASP G 70 22.110 33.767 169.041 1.00 34.98 N +ATOM 10366 CA ASP G 70 21.209 33.772 167.878 1.00 43.82 C +ATOM 10367 C ASP G 70 19.989 34.689 167.936 1.00 42.28 C +ATOM 10368 O ASP G 70 19.154 34.678 167.016 1.00 43.73 O +ATOM 10369 CB ASP G 70 20.730 32.344 167.552 1.00 57.85 C +ATOM 10370 CG ASP G 70 21.780 31.513 166.826 1.00 64.70 C +ATOM 10371 OD1 ASP G 70 22.784 32.080 166.329 1.00 71.38 O +ATOM 10372 OD2 ASP G 70 21.587 30.280 166.754 1.00 71.88 O +ATOM 10373 N ILE G 71 19.858 35.459 169.008 1.00 37.44 N +ATOM 10374 CA ILE G 71 18.717 36.353 169.098 1.00 33.50 C +ATOM 10375 C ILE G 71 19.135 37.818 169.207 1.00 25.94 C +ATOM 10376 O ILE G 71 18.852 38.626 168.323 1.00 23.95 O +ATOM 10377 CB ILE G 71 17.792 35.973 170.272 1.00 32.92 C +ATOM 10378 CG1 ILE G 71 17.258 34.556 170.091 1.00 39.45 C +ATOM 10379 CG2 ILE G 71 16.628 36.936 170.345 1.00 22.78 C +ATOM 10380 CD1 ILE G 71 16.337 34.112 171.219 1.00 49.60 C +ATOM 10381 N GLY G 72 19.810 38.148 170.299 1.00 22.24 N +ATOM 10382 CA GLY G 72 20.243 39.512 170.532 1.00 18.76 C +ATOM 10383 C GLY G 72 20.308 39.835 172.023 1.00 18.78 C +ATOM 10384 O GLY G 72 20.546 38.960 172.872 1.00 15.79 O +ATOM 10385 N TYR G 73 20.118 41.108 172.348 1.00 14.56 N +ATOM 10386 CA TYR G 73 20.167 41.543 173.732 1.00 10.69 C +ATOM 10387 C TYR G 73 18.864 41.230 174.425 1.00 12.42 C +ATOM 10388 O TYR G 73 17.778 41.507 173.906 1.00 12.31 O +ATOM 10389 CB TYR G 73 20.483 43.030 173.825 1.00 9.09 C +ATOM 10390 CG TYR G 73 21.864 43.340 173.349 1.00 8.50 C +ATOM 10391 CD1 TYR G 73 22.956 43.071 174.150 1.00 8.50 C +ATOM 10392 CD2 TYR G 73 22.083 43.859 172.084 1.00 8.50 C +ATOM 10393 CE1 TYR G 73 24.246 43.306 173.705 1.00 10.86 C +ATOM 10394 CE2 TYR G 73 23.360 44.100 171.626 1.00 8.50 C +ATOM 10395 CZ TYR G 73 24.442 43.821 172.437 1.00 13.27 C +ATOM 10396 OH TYR G 73 25.728 44.056 171.982 1.00 26.17 O +ATOM 10397 N SER G 74 18.991 40.645 175.607 1.00 13.15 N +ATOM 10398 CA SER G 74 17.859 40.265 176.425 1.00 11.14 C +ATOM 10399 C SER G 74 17.881 41.128 177.668 1.00 12.33 C +ATOM 10400 O SER G 74 18.713 40.920 178.568 1.00 17.94 O +ATOM 10401 CB SER G 74 17.993 38.796 176.809 1.00 17.82 C +ATOM 10402 OG SER G 74 17.022 38.415 177.759 1.00 34.87 O +ATOM 10403 N PHE G 75 17.000 42.123 177.706 1.00 11.89 N +ATOM 10404 CA PHE G 75 16.917 43.020 178.855 1.00 11.10 C +ATOM 10405 C PHE G 75 15.739 42.609 179.718 1.00 11.85 C +ATOM 10406 O PHE G 75 14.592 42.648 179.272 1.00 11.03 O +ATOM 10407 CB PHE G 75 16.730 44.459 178.404 1.00 12.15 C +ATOM 10408 CG PHE G 75 16.611 45.430 179.540 1.00 8.50 C +ATOM 10409 CD1 PHE G 75 17.688 45.661 180.392 1.00 12.20 C +ATOM 10410 CD2 PHE G 75 15.426 46.106 179.762 1.00 8.50 C +ATOM 10411 CE1 PHE G 75 17.579 46.551 181.448 1.00 8.50 C +ATOM 10412 CE2 PHE G 75 15.311 46.993 180.812 1.00 8.50 C +ATOM 10413 CZ PHE G 75 16.391 47.216 181.659 1.00 10.17 C +ATOM 10414 N THR G 76 16.021 42.225 180.957 1.00 15.52 N +ATOM 10415 CA THR G 76 14.975 41.791 181.876 1.00 15.04 C +ATOM 10416 C THR G 76 14.994 42.543 183.211 1.00 9.90 C +ATOM 10417 O THR G 76 16.034 42.705 183.858 1.00 10.43 O +ATOM 10418 CB THR G 76 15.012 40.213 182.077 1.00 24.62 C +ATOM 10419 OG1 THR G 76 14.743 39.869 183.446 1.00 34.66 O +ATOM 10420 CG2 THR G 76 16.368 39.607 181.657 1.00 22.93 C +ATOM 10421 N VAL G 77 13.843 43.063 183.588 1.00 8.50 N +ATOM 10422 CA VAL G 77 13.718 43.774 184.852 1.00 18.08 C +ATOM 10423 C VAL G 77 12.502 43.226 185.603 1.00 23.60 C +ATOM 10424 O VAL G 77 11.392 43.136 185.046 1.00 26.82 O +ATOM 10425 CB VAL G 77 13.625 45.345 184.660 1.00 22.80 C +ATOM 10426 CG1 VAL G 77 12.905 45.707 183.364 1.00 17.16 C +ATOM 10427 CG2 VAL G 77 12.921 46.006 185.860 1.00 17.40 C +ATOM 10428 N GLY G 78 12.740 42.783 186.834 1.00 21.43 N +ATOM 10429 CA GLY G 78 11.677 42.242 187.656 1.00 21.13 C +ATOM 10430 C GLY G 78 11.236 40.876 187.170 1.00 23.79 C +ATOM 10431 O GLY G 78 10.042 40.550 187.204 1.00 34.59 O +ATOM 10432 N GLY G 79 12.189 40.083 186.693 1.00 17.95 N +ATOM 10433 CA GLY G 79 11.860 38.751 186.218 1.00 19.09 C +ATOM 10434 C GLY G 79 11.201 38.681 184.849 1.00 21.45 C +ATOM 10435 O GLY G 79 11.097 37.585 184.270 1.00 23.18 O +ATOM 10436 N SER G 80 10.742 39.823 184.331 1.00 22.34 N +ATOM 10437 CA SER G 80 10.113 39.881 183.004 1.00 23.82 C +ATOM 10438 C SER G 80 11.130 40.327 181.938 1.00 24.91 C +ATOM 10439 O SER G 80 11.781 41.390 182.049 1.00 28.13 O +ATOM 10440 CB SER G 80 8.884 40.800 183.020 1.00 31.45 C +ATOM 10441 OG SER G 80 7.864 40.264 183.850 1.00 40.99 O +ATOM 10442 N GLU G 81 11.252 39.490 180.908 1.00 22.25 N +ATOM 10443 CA GLU G 81 12.197 39.689 179.808 1.00 19.17 C +ATOM 10444 C GLU G 81 11.618 40.456 178.608 1.00 20.20 C +ATOM 10445 O GLU G 81 10.391 40.525 178.416 1.00 21.87 O +ATOM 10446 CB GLU G 81 12.706 38.303 179.370 1.00 14.96 C +ATOM 10447 CG GLU G 81 13.693 38.276 178.231 1.00 22.65 C +ATOM 10448 CD GLU G 81 13.875 36.877 177.669 1.00 35.56 C +ATOM 10449 OE1 GLU G 81 12.874 36.296 177.180 1.00 40.42 O +ATOM 10450 OE2 GLU G 81 15.019 36.359 177.712 1.00 40.66 O +ATOM 10451 N ILE G 82 12.521 41.030 177.813 1.00 21.40 N +ATOM 10452 CA ILE G 82 12.172 41.771 176.604 1.00 14.19 C +ATOM 10453 C ILE G 82 13.383 41.606 175.669 1.00 14.38 C +ATOM 10454 O ILE G 82 14.541 41.464 176.128 1.00 12.31 O +ATOM 10455 CB ILE G 82 11.863 43.242 176.931 1.00 10.87 C +ATOM 10456 CG1 ILE G 82 10.900 43.794 175.900 1.00 8.50 C +ATOM 10457 CG2 ILE G 82 13.147 44.087 176.995 1.00 11.05 C +ATOM 10458 CD1 ILE G 82 10.326 45.117 176.320 1.00 24.70 C +ATOM 10459 N LEU G 83 13.137 41.602 174.368 1.00 11.74 N +ATOM 10460 CA LEU G 83 14.237 41.385 173.446 1.00 13.18 C +ATOM 10461 C LEU G 83 14.565 42.499 172.470 1.00 16.00 C +ATOM 10462 O LEU G 83 13.682 43.170 171.940 1.00 17.10 O +ATOM 10463 CB LEU G 83 13.999 40.085 172.670 1.00 14.61 C +ATOM 10464 CG LEU G 83 14.652 38.787 173.144 1.00 12.74 C +ATOM 10465 CD1 LEU G 83 14.529 38.615 174.640 1.00 23.13 C +ATOM 10466 CD2 LEU G 83 14.001 37.627 172.429 1.00 19.16 C +ATOM 10467 N PHE G 84 15.859 42.648 172.220 1.00 17.83 N +ATOM 10468 CA PHE G 84 16.376 43.615 171.278 1.00 12.77 C +ATOM 10469 C PHE G 84 17.197 42.792 170.318 1.00 14.00 C +ATOM 10470 O PHE G 84 18.356 42.440 170.576 1.00 10.43 O +ATOM 10471 CB PHE G 84 17.194 44.676 171.988 1.00 11.20 C +ATOM 10472 CG PHE G 84 16.352 45.626 172.745 1.00 14.43 C +ATOM 10473 CD1 PHE G 84 15.420 46.430 172.077 1.00 11.13 C +ATOM 10474 CD2 PHE G 84 16.428 45.687 174.129 1.00 30.25 C +ATOM 10475 CE1 PHE G 84 14.563 47.291 172.775 1.00 8.50 C +ATOM 10476 CE2 PHE G 84 15.574 46.550 174.852 1.00 35.13 C +ATOM 10477 CZ PHE G 84 14.636 47.355 174.165 1.00 23.15 C +ATOM 10478 N GLU G 85 16.523 42.407 169.243 1.00 19.97 N +ATOM 10479 CA GLU G 85 17.111 41.576 168.208 1.00 27.71 C +ATOM 10480 C GLU G 85 18.311 42.195 167.476 1.00 28.06 C +ATOM 10481 O GLU G 85 18.293 43.372 167.070 1.00 27.78 O +ATOM 10482 CB GLU G 85 16.022 41.160 167.227 1.00 38.74 C +ATOM 10483 CG GLU G 85 14.775 40.618 167.920 1.00 58.85 C +ATOM 10484 CD GLU G 85 14.033 39.610 167.064 1.00 75.86 C +ATOM 10485 OE1 GLU G 85 13.214 40.050 166.222 1.00 83.44 O +ATOM 10486 OE2 GLU G 85 14.280 38.385 167.229 1.00 77.01 O +ATOM 10487 N VAL G 86 19.366 41.397 167.356 1.00 28.54 N +ATOM 10488 CA VAL G 86 20.586 41.803 166.674 1.00 35.32 C +ATOM 10489 C VAL G 86 20.964 40.636 165.767 1.00 47.32 C +ATOM 10490 O VAL G 86 21.559 39.659 166.225 1.00 56.08 O +ATOM 10491 CB VAL G 86 21.717 42.082 167.664 1.00 21.87 C +ATOM 10492 CG1 VAL G 86 23.003 42.345 166.913 1.00 26.74 C +ATOM 10493 CG2 VAL G 86 21.367 43.274 168.525 1.00 37.47 C +ATOM 10494 N PRO G 87 20.614 40.720 164.466 1.00 53.31 N +ATOM 10495 CA PRO G 87 20.878 39.699 163.443 1.00 62.31 C +ATOM 10496 C PRO G 87 22.347 39.422 163.125 1.00 71.51 C +ATOM 10497 O PRO G 87 22.839 38.303 163.319 1.00 77.10 O +ATOM 10498 CB PRO G 87 20.144 40.250 162.224 1.00 57.58 C +ATOM 10499 CG PRO G 87 20.284 41.715 162.395 1.00 53.78 C +ATOM 10500 CD PRO G 87 19.977 41.899 163.857 1.00 56.68 C +ATOM 10501 N GLU G 88 23.025 40.431 162.592 1.00 75.46 N +ATOM 10502 CA GLU G 88 24.425 40.310 162.230 1.00 77.44 C +ATOM 10503 C GLU G 88 25.275 40.691 163.447 1.00 71.91 C +ATOM 10504 O GLU G 88 25.294 41.850 163.864 1.00 71.07 O +ATOM 10505 CB GLU G 88 24.725 41.233 161.043 1.00 86.25 C +ATOM 10506 CG GLU G 88 26.063 40.978 160.353 1.00100.52 C +ATOM 10507 CD GLU G 88 26.432 42.073 159.360 1.00109.27 C +ATOM 10508 OE1 GLU G 88 25.527 42.547 158.625 1.00110.24 O +ATOM 10509 OE2 GLU G 88 27.629 42.460 159.323 1.00110.78 O +ATOM 10510 N VAL G 89 25.922 39.704 164.055 1.00 66.63 N +ATOM 10511 CA VAL G 89 26.761 39.972 165.210 1.00 65.73 C +ATOM 10512 C VAL G 89 28.177 40.247 164.752 1.00 62.34 C +ATOM 10513 O VAL G 89 28.707 39.549 163.883 1.00 62.55 O +ATOM 10514 CB VAL G 89 26.750 38.794 166.231 1.00 75.17 C +ATOM 10515 CG1 VAL G 89 27.451 37.538 165.667 1.00 70.08 C +ATOM 10516 CG2 VAL G 89 27.385 39.240 167.547 1.00 79.55 C +ATOM 10517 N THR G 90 28.780 41.281 165.320 1.00 60.45 N +ATOM 10518 CA THR G 90 30.142 41.642 164.965 1.00 61.44 C +ATOM 10519 C THR G 90 31.027 41.572 166.199 1.00 54.19 C +ATOM 10520 O THR G 90 30.564 41.795 167.323 1.00 57.78 O +ATOM 10521 CB THR G 90 30.209 43.066 164.326 1.00 70.37 C +ATOM 10522 OG1 THR G 90 31.519 43.294 163.783 1.00 73.98 O +ATOM 10523 CG2 THR G 90 29.880 44.155 165.361 1.00 74.16 C +ATOM 10524 N VAL G 91 32.294 41.247 165.983 1.00 42.90 N +ATOM 10525 CA VAL G 91 33.249 41.149 167.070 1.00 38.81 C +ATOM 10526 C VAL G 91 34.069 42.440 167.178 1.00 35.19 C +ATOM 10527 O VAL G 91 34.853 42.775 166.292 1.00 42.28 O +ATOM 10528 CB VAL G 91 34.157 39.915 166.888 1.00 43.05 C +ATOM 10529 CG1 VAL G 91 34.832 39.942 165.507 1.00 49.59 C +ATOM 10530 CG2 VAL G 91 35.192 39.828 168.023 1.00 48.15 C +ATOM 10531 N ALA G 92 33.830 43.185 168.251 1.00 25.64 N +ATOM 10532 CA ALA G 92 34.512 44.441 168.521 1.00 14.26 C +ATOM 10533 C ALA G 92 33.996 44.903 169.871 1.00 11.22 C +ATOM 10534 O ALA G 92 32.964 44.406 170.340 1.00 14.85 O +ATOM 10535 CB ALA G 92 34.151 45.464 167.455 1.00 21.73 C +ATOM 10536 N PRO G 93 34.742 45.786 170.564 1.00 8.50 N +ATOM 10537 CA PRO G 93 34.182 46.200 171.844 1.00 8.50 C +ATOM 10538 C PRO G 93 32.850 46.878 171.543 1.00 11.36 C +ATOM 10539 O PRO G 93 32.668 47.469 170.475 1.00 22.75 O +ATOM 10540 CB PRO G 93 35.213 47.196 172.355 1.00 8.50 C +ATOM 10541 CG PRO G 93 36.480 46.692 171.783 1.00 8.50 C +ATOM 10542 CD PRO G 93 36.087 46.359 170.381 1.00 8.65 C +ATOM 10543 N VAL G 94 31.898 46.737 172.450 1.00 10.17 N +ATOM 10544 CA VAL G 94 30.595 47.339 172.277 1.00 8.50 C +ATOM 10545 C VAL G 94 30.212 48.086 173.563 1.00 12.13 C +ATOM 10546 O VAL G 94 30.623 47.708 174.668 1.00 15.43 O +ATOM 10547 CB VAL G 94 29.573 46.277 171.848 1.00 8.50 C +ATOM 10548 CG1 VAL G 94 29.833 45.002 172.554 1.00 14.31 C +ATOM 10549 CG2 VAL G 94 28.167 46.733 172.095 1.00 8.50 C +ATOM 10550 N HIS G 95 29.537 49.218 173.408 1.00 9.49 N +ATOM 10551 CA HIS G 95 29.128 50.037 174.536 1.00 8.50 C +ATOM 10552 C HIS G 95 27.616 50.093 174.544 1.00 10.31 C +ATOM 10553 O HIS G 95 27.007 50.431 173.528 1.00 17.60 O +ATOM 10554 CB HIS G 95 29.713 51.453 174.381 1.00 8.50 C +ATOM 10555 CG HIS G 95 29.142 52.463 175.327 1.00 8.50 C +ATOM 10556 ND1 HIS G 95 29.694 52.708 176.566 1.00 8.50 N +ATOM 10557 CD2 HIS G 95 28.074 53.288 175.217 1.00 8.50 C +ATOM 10558 CE1 HIS G 95 28.990 53.643 177.179 1.00 11.39 C +ATOM 10559 NE2 HIS G 95 28.002 54.009 176.382 1.00 11.55 N +ATOM 10560 N ILE G 96 27.007 49.774 175.678 1.00 9.64 N +ATOM 10561 CA ILE G 96 25.556 49.825 175.778 1.00 9.58 C +ATOM 10562 C ILE G 96 25.097 50.651 176.971 1.00 8.50 C +ATOM 10563 O ILE G 96 25.809 50.754 177.960 1.00 10.53 O +ATOM 10564 CB ILE G 96 24.923 48.414 175.897 1.00 15.42 C +ATOM 10565 CG1 ILE G 96 25.466 47.686 177.121 1.00 18.29 C +ATOM 10566 CG2 ILE G 96 25.194 47.591 174.651 1.00 14.93 C +ATOM 10567 CD1 ILE G 96 24.723 46.429 177.430 1.00 22.98 C +ATOM 10568 N CYS G 97 23.960 51.320 176.811 1.00 9.96 N +ATOM 10569 CA CYS G 97 23.320 52.110 177.858 1.00 9.83 C +ATOM 10570 C CYS G 97 21.882 51.660 177.760 1.00 12.91 C +ATOM 10571 O CYS G 97 21.335 51.590 176.663 1.00 12.81 O +ATOM 10572 CB CYS G 97 23.334 53.600 177.585 1.00 8.50 C +ATOM 10573 SG CYS G 97 24.836 54.474 178.078 1.00 18.95 S +ATOM 10574 N THR G 98 21.273 51.336 178.892 1.00 14.65 N +ATOM 10575 CA THR G 98 19.890 50.893 178.899 1.00 11.26 C +ATOM 10576 C THR G 98 19.206 51.573 180.079 1.00 11.66 C +ATOM 10577 O THR G 98 19.839 51.811 181.118 1.00 10.61 O +ATOM 10578 CB THR G 98 19.804 49.352 178.987 1.00 12.26 C +ATOM 10579 OG1 THR G 98 18.437 48.935 178.919 1.00 17.35 O +ATOM 10580 CG2 THR G 98 20.445 48.840 180.264 1.00 10.54 C +ATOM 10581 N SER G 99 17.939 51.941 179.893 1.00 14.28 N +ATOM 10582 CA SER G 99 17.174 52.627 180.938 1.00 15.08 C +ATOM 10583 C SER G 99 15.721 52.168 181.036 1.00 17.02 C +ATOM 10584 O SER G 99 15.131 51.718 180.041 1.00 23.55 O +ATOM 10585 CB SER G 99 17.248 54.162 180.757 1.00 17.86 C +ATOM 10586 OG SER G 99 16.861 54.593 179.453 1.00 20.04 O +ATOM 10587 N TRP G 100 15.156 52.283 182.241 1.00 18.21 N +ATOM 10588 CA TRP G 100 13.770 51.889 182.513 1.00 17.53 C +ATOM 10589 C TRP G 100 13.101 52.921 183.430 1.00 15.75 C +ATOM 10590 O TRP G 100 13.759 53.506 184.307 1.00 15.45 O +ATOM 10591 CB TRP G 100 13.737 50.485 183.149 1.00 23.52 C +ATOM 10592 CG TRP G 100 12.409 50.097 183.759 1.00 18.81 C +ATOM 10593 CD1 TRP G 100 11.307 49.597 183.110 1.00 8.62 C +ATOM 10594 CD2 TRP G 100 12.063 50.179 185.142 1.00 12.47 C +ATOM 10595 NE1 TRP G 100 10.307 49.364 184.010 1.00 10.59 N +ATOM 10596 CE2 TRP G 100 10.741 49.710 185.267 1.00 13.04 C +ATOM 10597 CE3 TRP G 100 12.743 50.610 186.287 1.00 12.06 C +ATOM 10598 CZ2 TRP G 100 10.082 49.657 186.499 1.00 10.21 C +ATOM 10599 CZ3 TRP G 100 12.089 50.561 187.508 1.00 17.92 C +ATOM 10600 CH2 TRP G 100 10.772 50.088 187.604 1.00 14.34 C +ATOM 10601 N GLU G 101 11.798 53.120 183.233 1.00 13.73 N +ATOM 10602 CA GLU G 101 11.035 54.081 184.014 1.00 17.03 C +ATOM 10603 C GLU G 101 9.746 53.431 184.486 1.00 19.73 C +ATOM 10604 O GLU G 101 8.912 53.074 183.652 1.00 23.16 O +ATOM 10605 CB GLU G 101 10.705 55.297 183.138 1.00 24.91 C +ATOM 10606 CG GLU G 101 9.811 56.351 183.791 1.00 28.51 C +ATOM 10607 CD GLU G 101 9.460 57.491 182.859 1.00 23.03 C +ATOM 10608 OE1 GLU G 101 8.609 57.284 181.965 1.00 16.86 O +ATOM 10609 OE2 GLU G 101 10.022 58.596 183.044 1.00 28.90 O +ATOM 10610 N SER G 102 9.560 53.316 185.804 1.00 18.63 N +ATOM 10611 CA SER G 102 8.351 52.694 186.345 1.00 17.41 C +ATOM 10612 C SER G 102 7.086 53.377 185.860 1.00 18.99 C +ATOM 10613 O SER G 102 6.158 52.709 185.398 1.00 19.87 O +ATOM 10614 CB SER G 102 8.365 52.699 187.868 1.00 20.91 C +ATOM 10615 OG SER G 102 7.087 52.333 188.384 1.00 15.02 O +ATOM 10616 N ALA G 103 7.088 54.710 185.905 1.00 16.84 N +ATOM 10617 CA ALA G 103 5.937 55.509 185.498 1.00 16.07 C +ATOM 10618 C ALA G 103 5.278 55.206 184.140 1.00 17.85 C +ATOM 10619 O ALA G 103 4.072 55.433 183.972 1.00 27.81 O +ATOM 10620 CB ALA G 103 6.281 56.976 185.590 1.00 19.80 C +ATOM 10621 N SER G 104 6.037 54.698 183.175 1.00 13.62 N +ATOM 10622 CA SER G 104 5.464 54.412 181.858 1.00 13.60 C +ATOM 10623 C SER G 104 5.829 53.022 181.328 1.00 15.02 C +ATOM 10624 O SER G 104 5.188 52.498 180.396 1.00 12.87 O +ATOM 10625 CB SER G 104 5.958 55.452 180.868 1.00 15.16 C +ATOM 10626 OG SER G 104 7.361 55.304 180.702 1.00 23.65 O +ATOM 10627 N GLY G 105 6.883 52.451 181.902 1.00 14.90 N +ATOM 10628 CA GLY G 105 7.340 51.142 181.484 1.00 15.17 C +ATOM 10629 C GLY G 105 8.242 51.255 180.270 1.00 16.82 C +ATOM 10630 O GLY G 105 8.711 50.244 179.743 1.00 22.04 O +ATOM 10631 N ILE G 106 8.511 52.477 179.824 1.00 12.70 N +ATOM 10632 CA ILE G 106 9.373 52.643 178.664 1.00 10.90 C +ATOM 10633 C ILE G 106 10.833 52.328 178.961 1.00 10.38 C +ATOM 10634 O ILE G 106 11.462 52.912 179.853 1.00 11.77 O +ATOM 10635 CB ILE G 106 9.280 54.041 178.074 1.00 8.50 C +ATOM 10636 CG1 ILE G 106 7.877 54.280 177.528 1.00 15.76 C +ATOM 10637 CG2 ILE G 106 10.258 54.188 176.951 1.00 8.50 C +ATOM 10638 CD1 ILE G 106 7.697 55.657 176.904 1.00 21.74 C +ATOM 10639 N VAL G 107 11.360 51.384 178.205 1.00 10.24 N +ATOM 10640 CA VAL G 107 12.751 50.994 178.331 1.00 11.11 C +ATOM 10641 C VAL G 107 13.449 51.315 176.994 1.00 9.98 C +ATOM 10642 O VAL G 107 12.880 51.080 175.924 1.00 10.88 O +ATOM 10643 CB VAL G 107 12.889 49.494 178.728 1.00 15.23 C +ATOM 10644 CG1 VAL G 107 11.845 48.628 178.008 1.00 20.71 C +ATOM 10645 CG2 VAL G 107 14.282 49.000 178.400 1.00 17.53 C +ATOM 10646 N GLU G 108 14.610 51.965 177.075 1.00 9.50 N +ATOM 10647 CA GLU G 108 15.404 52.339 175.905 1.00 11.10 C +ATOM 10648 C GLU G 108 16.660 51.475 175.931 1.00 13.50 C +ATOM 10649 O GLU G 108 17.156 51.132 177.014 1.00 11.50 O +ATOM 10650 CB GLU G 108 15.872 53.795 176.004 1.00 17.00 C +ATOM 10651 CG GLU G 108 14.813 54.900 176.016 1.00 15.46 C +ATOM 10652 CD GLU G 108 15.422 56.291 176.342 1.00 26.82 C +ATOM 10653 OE1 GLU G 108 16.633 56.384 176.669 1.00 22.79 O +ATOM 10654 OE2 GLU G 108 14.686 57.302 176.304 1.00 31.34 O +ATOM 10655 N PHE G 109 17.186 51.138 174.758 1.00 12.53 N +ATOM 10656 CA PHE G 109 18.408 50.345 174.692 1.00 10.83 C +ATOM 10657 C PHE G 109 19.249 51.056 173.635 1.00 12.87 C +ATOM 10658 O PHE G 109 18.790 51.248 172.512 1.00 16.79 O +ATOM 10659 CB PHE G 109 18.096 48.906 174.276 1.00 8.50 C +ATOM 10660 CG PHE G 109 19.120 47.904 174.735 1.00 16.30 C +ATOM 10661 CD1 PHE G 109 19.032 47.334 175.994 1.00 13.52 C +ATOM 10662 CD2 PHE G 109 20.182 47.543 173.916 1.00 18.73 C +ATOM 10663 CE1 PHE G 109 19.996 46.423 176.429 1.00 18.80 C +ATOM 10664 CE2 PHE G 109 21.149 46.632 174.350 1.00 17.01 C +ATOM 10665 CZ PHE G 109 21.056 46.075 175.607 1.00 11.65 C +ATOM 10666 N TRP G 110 20.413 51.563 174.031 1.00 13.68 N +ATOM 10667 CA TRP G 110 21.308 52.279 173.121 1.00 11.18 C +ATOM 10668 C TRP G 110 22.553 51.433 172.904 1.00 14.50 C +ATOM 10669 O TRP G 110 23.269 51.118 173.864 1.00 17.79 O +ATOM 10670 CB TRP G 110 21.762 53.607 173.733 1.00 8.50 C +ATOM 10671 CG TRP G 110 20.684 54.569 173.975 1.00 12.12 C +ATOM 10672 CD1 TRP G 110 19.703 54.472 174.907 1.00 19.00 C +ATOM 10673 CD2 TRP G 110 20.440 55.782 173.257 1.00 12.39 C +ATOM 10674 NE1 TRP G 110 18.850 55.548 174.816 1.00 20.56 N +ATOM 10675 CE2 TRP G 110 19.278 56.368 173.809 1.00 14.27 C +ATOM 10676 CE3 TRP G 110 21.080 56.425 172.197 1.00 9.64 C +ATOM 10677 CZ2 TRP G 110 18.741 57.564 173.337 1.00 12.15 C +ATOM 10678 CZ3 TRP G 110 20.549 57.613 171.721 1.00 15.08 C +ATOM 10679 CH2 TRP G 110 19.385 58.171 172.293 1.00 18.58 C +ATOM 10680 N VAL G 111 22.832 51.073 171.657 1.00 12.96 N +ATOM 10681 CA VAL G 111 24.027 50.288 171.370 1.00 9.48 C +ATOM 10682 C VAL G 111 24.956 51.166 170.562 1.00 11.70 C +ATOM 10683 O VAL G 111 24.577 51.683 169.511 1.00 14.85 O +ATOM 10684 CB VAL G 111 23.704 49.027 170.585 1.00 9.52 C +ATOM 10685 CG1 VAL G 111 24.966 48.239 170.334 1.00 8.50 C +ATOM 10686 CG2 VAL G 111 22.708 48.184 171.358 1.00 17.73 C +ATOM 10687 N ASP G 112 26.154 51.377 171.096 1.00 10.98 N +ATOM 10688 CA ASP G 112 27.169 52.215 170.461 1.00 9.75 C +ATOM 10689 C ASP G 112 26.703 53.637 170.123 1.00 10.74 C +ATOM 10690 O ASP G 112 27.019 54.167 169.062 1.00 12.31 O +ATOM 10691 CB ASP G 112 27.752 51.541 169.215 1.00 12.96 C +ATOM 10692 CG ASP G 112 28.841 50.536 169.542 1.00 13.89 C +ATOM 10693 OD1 ASP G 112 29.542 50.726 170.561 1.00 8.50 O +ATOM 10694 OD2 ASP G 112 29.008 49.566 168.761 1.00 11.88 O +ATOM 10695 N GLY G 113 25.965 54.253 171.041 1.00 12.76 N +ATOM 10696 CA GLY G 113 25.515 55.615 170.837 1.00 9.27 C +ATOM 10697 C GLY G 113 24.275 55.780 169.996 1.00 11.57 C +ATOM 10698 O GLY G 113 23.753 56.896 169.887 1.00 17.49 O +ATOM 10699 N LYS G 114 23.811 54.692 169.385 1.00 8.50 N +ATOM 10700 CA LYS G 114 22.611 54.734 168.552 1.00 8.61 C +ATOM 10701 C LYS G 114 21.479 53.986 169.251 1.00 8.50 C +ATOM 10702 O LYS G 114 21.645 52.857 169.709 1.00 8.50 O +ATOM 10703 CB LYS G 114 22.874 54.145 167.156 1.00 22.43 C +ATOM 10704 CG LYS G 114 23.669 55.049 166.204 1.00 17.93 C +ATOM 10705 CD LYS G 114 23.992 54.356 164.853 1.00 26.37 C +ATOM 10706 CE LYS G 114 22.714 53.941 164.059 1.00 43.51 C +ATOM 10707 NZ LYS G 114 22.845 53.821 162.539 1.00 18.64 N +ATOM 10708 N PRO G 115 20.311 54.623 169.352 1.00 8.50 N +ATOM 10709 CA PRO G 115 19.125 54.079 170.000 1.00 8.66 C +ATOM 10710 C PRO G 115 18.312 53.067 169.219 1.00 11.69 C +ATOM 10711 O PRO G 115 18.138 53.186 168.006 1.00 12.31 O +ATOM 10712 CB PRO G 115 18.293 55.322 170.223 1.00 15.00 C +ATOM 10713 CG PRO G 115 18.517 56.061 168.951 1.00 8.50 C +ATOM 10714 CD PRO G 115 20.009 55.945 168.770 1.00 9.89 C +ATOM 10715 N ARG G 116 17.806 52.080 169.947 1.00 10.64 N +ATOM 10716 CA ARG G 116 16.940 51.053 169.396 1.00 9.88 C +ATOM 10717 C ARG G 116 15.586 51.645 169.741 1.00 13.31 C +ATOM 10718 O ARG G 116 15.519 52.585 170.549 1.00 14.82 O +ATOM 10719 CB ARG G 116 17.132 49.729 170.133 1.00 8.50 C +ATOM 10720 CG ARG G 116 18.558 49.219 170.125 1.00 8.50 C +ATOM 10721 CD ARG G 116 18.950 48.646 168.783 1.00 28.09 C +ATOM 10722 NE ARG G 116 18.373 47.320 168.575 1.00 35.12 N +ATOM 10723 CZ ARG G 116 17.270 47.086 167.874 1.00 40.27 C +ATOM 10724 NH1 ARG G 116 16.617 48.092 167.306 1.00 44.60 N +ATOM 10725 NH2 ARG G 116 16.816 45.846 167.742 1.00 43.00 N +ATOM 10726 N VAL G 117 14.509 51.103 169.172 1.00 15.01 N +ATOM 10727 CA VAL G 117 13.173 51.643 169.451 1.00 11.28 C +ATOM 10728 C VAL G 117 12.812 51.512 170.933 1.00 16.77 C +ATOM 10729 O VAL G 117 13.440 50.741 171.670 1.00 22.39 O +ATOM 10730 CB VAL G 117 12.078 50.968 168.625 1.00 8.50 C +ATOM 10731 CG1 VAL G 117 10.891 51.916 168.506 1.00 12.53 C +ATOM 10732 CG2 VAL G 117 12.606 50.560 167.263 1.00 9.36 C +ATOM 10733 N ARG G 118 11.834 52.295 171.375 1.00 15.38 N +ATOM 10734 CA ARG G 118 11.403 52.252 172.767 1.00 12.62 C +ATOM 10735 C ARG G 118 10.363 51.160 172.955 1.00 13.01 C +ATOM 10736 O ARG G 118 9.435 51.025 172.148 1.00 18.38 O +ATOM 10737 CB ARG G 118 10.797 53.583 173.196 1.00 11.91 C +ATOM 10738 CG ARG G 118 11.717 54.765 173.074 1.00 8.50 C +ATOM 10739 CD ARG G 118 11.111 55.936 173.820 1.00 16.00 C +ATOM 10740 NE ARG G 118 11.340 57.213 173.162 1.00 8.50 N +ATOM 10741 CZ ARG G 118 12.176 58.133 173.609 1.00 10.37 C +ATOM 10742 NH1 ARG G 118 12.869 57.928 174.713 1.00 13.67 N +ATOM 10743 NH2 ARG G 118 12.323 59.259 172.949 1.00 16.33 N +ATOM 10744 N LYS G 119 10.494 50.413 174.045 1.00 12.89 N +ATOM 10745 CA LYS G 119 9.569 49.335 174.333 1.00 13.54 C +ATOM 10746 C LYS G 119 8.983 49.507 175.729 1.00 13.28 C +ATOM 10747 O LYS G 119 9.470 50.332 176.506 1.00 11.38 O +ATOM 10748 CB LYS G 119 10.287 47.989 174.171 1.00 16.35 C +ATOM 10749 CG LYS G 119 10.709 47.729 172.740 1.00 12.15 C +ATOM 10750 CD LYS G 119 11.275 46.346 172.534 1.00 16.81 C +ATOM 10751 CE LYS G 119 11.423 46.054 171.047 1.00 26.09 C +ATOM 10752 NZ LYS G 119 12.002 44.717 170.757 1.00 34.76 N +ATOM 10753 N SER G 120 7.902 48.777 176.017 1.00 17.59 N +ATOM 10754 CA SER G 120 7.237 48.842 177.327 1.00 15.10 C +ATOM 10755 C SER G 120 7.560 47.588 178.137 1.00 10.91 C +ATOM 10756 O SER G 120 7.548 46.484 177.605 1.00 15.32 O +ATOM 10757 CB SER G 120 5.717 48.958 177.145 1.00 17.58 C +ATOM 10758 OG SER G 120 5.095 49.483 178.305 1.00 32.06 O +ATOM 10759 N LEU G 121 7.832 47.759 179.420 1.00 9.57 N +ATOM 10760 CA LEU G 121 8.167 46.641 180.279 1.00 11.69 C +ATOM 10761 C LEU G 121 8.072 47.003 181.773 1.00 20.18 C +ATOM 10762 O LEU G 121 8.640 48.017 182.228 1.00 15.01 O +ATOM 10763 CB LEU G 121 9.572 46.124 179.938 1.00 8.50 C +ATOM 10764 CG LEU G 121 10.237 45.130 180.901 1.00 13.92 C +ATOM 10765 CD1 LEU G 121 9.392 43.891 181.098 1.00 10.26 C +ATOM 10766 CD2 LEU G 121 11.590 44.754 180.368 1.00 15.15 C +ATOM 10767 N LYS G 122 7.310 46.180 182.509 1.00 22.66 N +ATOM 10768 CA LYS G 122 7.110 46.324 183.950 1.00 14.24 C +ATOM 10769 C LYS G 122 6.665 47.689 184.447 1.00 18.25 C +ATOM 10770 O LYS G 122 7.244 48.216 185.412 1.00 17.99 O +ATOM 10771 CB LYS G 122 8.379 45.892 184.703 1.00 16.09 C +ATOM 10772 CG LYS G 122 8.502 44.384 184.908 1.00 23.84 C +ATOM 10773 CD LYS G 122 7.447 43.884 185.896 1.00 34.57 C +ATOM 10774 CE LYS G 122 7.546 42.397 186.113 1.00 28.17 C +ATOM 10775 NZ LYS G 122 6.571 41.906 187.128 1.00 50.12 N +ATOM 10776 N LYS G 123 5.626 48.250 183.823 1.00 19.05 N +ATOM 10777 CA LYS G 123 5.124 49.560 184.251 1.00 19.82 C +ATOM 10778 C LYS G 123 4.598 49.467 185.690 1.00 23.01 C +ATOM 10779 O LYS G 123 4.009 48.445 186.078 1.00 29.89 O +ATOM 10780 CB LYS G 123 3.997 50.056 183.343 1.00 15.73 C +ATOM 10781 CG LYS G 123 3.450 51.410 183.809 1.00 14.72 C +ATOM 10782 CD LYS G 123 2.008 51.637 183.414 1.00 19.59 C +ATOM 10783 CE LYS G 123 1.887 52.059 181.971 1.00 13.96 C +ATOM 10784 NZ LYS G 123 0.523 52.576 181.722 1.00 21.60 N +ATOM 10785 N GLY G 124 4.830 50.515 186.480 1.00 22.39 N +ATOM 10786 CA GLY G 124 4.358 50.517 187.848 1.00 21.27 C +ATOM 10787 C GLY G 124 5.199 49.699 188.805 1.00 23.10 C +ATOM 10788 O GLY G 124 5.040 49.847 190.021 1.00 33.80 O +ATOM 10789 N TYR G 125 6.078 48.838 188.290 1.00 16.89 N +ATOM 10790 CA TYR G 125 6.936 48.021 189.148 1.00 18.82 C +ATOM 10791 C TYR G 125 7.896 48.941 189.922 1.00 22.20 C +ATOM 10792 O TYR G 125 7.949 50.155 189.679 1.00 26.17 O +ATOM 10793 CB TYR G 125 7.725 47.010 188.302 1.00 12.93 C +ATOM 10794 CG TYR G 125 8.524 45.986 189.092 1.00 21.00 C +ATOM 10795 CD1 TYR G 125 7.913 44.841 189.605 1.00 30.27 C +ATOM 10796 CD2 TYR G 125 9.890 46.161 189.324 1.00 27.40 C +ATOM 10797 CE1 TYR G 125 8.638 43.892 190.330 1.00 31.29 C +ATOM 10798 CE2 TYR G 125 10.625 45.224 190.048 1.00 32.70 C +ATOM 10799 CZ TYR G 125 9.991 44.088 190.549 1.00 34.08 C +ATOM 10800 OH TYR G 125 10.702 43.143 191.262 1.00 36.26 O +ATOM 10801 N THR G 126 8.625 48.375 190.877 1.00 20.90 N +ATOM 10802 CA THR G 126 9.590 49.138 191.651 1.00 23.42 C +ATOM 10803 C THR G 126 10.736 48.193 192.043 1.00 24.37 C +ATOM 10804 O THR G 126 10.522 47.136 192.633 1.00 24.46 O +ATOM 10805 CB THR G 126 8.912 49.856 192.855 1.00 27.66 C +ATOM 10806 OG1 THR G 126 9.896 50.217 193.839 1.00 27.41 O +ATOM 10807 CG2 THR G 126 7.790 48.990 193.467 1.00 32.72 C +ATOM 10808 N VAL G 127 11.939 48.530 191.592 1.00 25.83 N +ATOM 10809 CA VAL G 127 13.131 47.719 191.834 1.00 18.87 C +ATOM 10810 C VAL G 127 13.621 47.785 193.276 1.00 16.16 C +ATOM 10811 O VAL G 127 13.658 48.858 193.880 1.00 10.53 O +ATOM 10812 CB VAL G 127 14.267 48.121 190.841 1.00 14.53 C +ATOM 10813 CG1 VAL G 127 15.561 47.384 191.140 1.00 17.95 C +ATOM 10814 CG2 VAL G 127 13.828 47.823 189.434 1.00 9.40 C +ATOM 10815 N GLY G 128 14.010 46.623 193.801 1.00 17.15 N +ATOM 10816 CA GLY G 128 14.501 46.513 195.166 1.00 27.15 C +ATOM 10817 C GLY G 128 15.789 47.276 195.434 1.00 31.41 C +ATOM 10818 O GLY G 128 16.690 47.271 194.598 1.00 33.56 O +ATOM 10819 N ALA G 129 15.887 47.880 196.622 1.00 34.24 N +ATOM 10820 CA ALA G 129 17.044 48.686 197.013 1.00 32.24 C +ATOM 10821 C ALA G 129 18.268 47.918 197.514 1.00 41.89 C +ATOM 10822 O ALA G 129 19.398 48.352 197.286 1.00 46.32 O +ATOM 10823 CB ALA G 129 16.627 49.708 198.031 1.00 33.35 C +ATOM 10824 N GLU G 130 18.066 46.830 198.258 1.00 46.90 N +ATOM 10825 CA GLU G 130 19.205 46.051 198.745 1.00 49.84 C +ATOM 10826 C GLU G 130 19.443 44.932 197.740 1.00 46.17 C +ATOM 10827 O GLU G 130 18.619 44.015 197.603 1.00 44.41 O +ATOM 10828 CB GLU G 130 18.946 45.502 200.149 1.00 65.36 C +ATOM 10829 CG GLU G 130 17.667 44.692 200.309 1.00 87.49 C +ATOM 10830 CD GLU G 130 17.497 44.176 201.722 1.00 98.19 C +ATOM 10831 OE1 GLU G 130 16.926 44.912 202.553 1.00107.84 O +ATOM 10832 OE2 GLU G 130 17.946 43.045 202.007 1.00102.40 O +ATOM 10833 N ALA G 131 20.562 45.019 197.025 1.00 42.33 N +ATOM 10834 CA ALA G 131 20.855 44.034 196.001 1.00 31.94 C +ATOM 10835 C ALA G 131 22.306 43.627 195.865 1.00 24.02 C +ATOM 10836 O ALA G 131 23.218 44.327 196.308 1.00 28.02 O +ATOM 10837 CB ALA G 131 20.336 44.534 194.664 1.00 34.73 C +ATOM 10838 N SER G 132 22.493 42.467 195.249 1.00 17.78 N +ATOM 10839 CA SER G 132 23.805 41.917 194.976 1.00 22.06 C +ATOM 10840 C SER G 132 23.985 42.155 193.475 1.00 25.83 C +ATOM 10841 O SER G 132 23.203 41.644 192.660 1.00 24.35 O +ATOM 10842 CB SER G 132 23.831 40.418 195.274 1.00 21.78 C +ATOM 10843 OG SER G 132 25.093 39.843 194.962 1.00 26.23 O +ATOM 10844 N ILE G 133 24.963 42.992 193.134 1.00 22.92 N +ATOM 10845 CA ILE G 133 25.266 43.335 191.749 1.00 16.07 C +ATOM 10846 C ILE G 133 26.558 42.610 191.343 1.00 17.25 C +ATOM 10847 O ILE G 133 27.646 42.887 191.885 1.00 17.31 O +ATOM 10848 CB ILE G 133 25.461 44.853 191.620 1.00 18.06 C +ATOM 10849 CG1 ILE G 133 24.239 45.582 192.176 1.00 16.29 C +ATOM 10850 CG2 ILE G 133 25.685 45.243 190.167 1.00 25.04 C +ATOM 10851 CD1 ILE G 133 24.381 47.083 192.179 1.00 12.89 C +ATOM 10852 N ILE G 134 26.447 41.691 190.388 1.00 12.13 N +ATOM 10853 CA ILE G 134 27.613 40.932 189.963 1.00 13.43 C +ATOM 10854 C ILE G 134 27.959 41.037 188.488 1.00 15.72 C +ATOM 10855 O ILE G 134 27.079 41.064 187.610 1.00 17.18 O +ATOM 10856 CB ILE G 134 27.497 39.453 190.402 1.00 22.11 C +ATOM 10857 CG1 ILE G 134 27.764 39.368 191.909 1.00 29.68 C +ATOM 10858 CG2 ILE G 134 28.446 38.542 189.604 1.00 10.57 C +ATOM 10859 CD1 ILE G 134 27.663 37.976 192.464 1.00 39.72 C +ATOM 10860 N LEU G 135 29.264 41.090 188.237 1.00 12.35 N +ATOM 10861 CA LEU G 135 29.801 41.211 186.903 1.00 11.71 C +ATOM 10862 C LEU G 135 30.453 39.904 186.512 1.00 14.42 C +ATOM 10863 O LEU G 135 31.191 39.323 187.303 1.00 14.58 O +ATOM 10864 CB LEU G 135 30.846 42.339 186.886 1.00 11.57 C +ATOM 10865 CG LEU G 135 30.464 43.744 186.389 1.00 12.09 C +ATOM 10866 CD1 LEU G 135 29.058 44.153 186.779 1.00 8.50 C +ATOM 10867 CD2 LEU G 135 31.473 44.739 186.907 1.00 11.82 C +ATOM 10868 N GLY G 136 30.154 39.426 185.311 1.00 18.28 N +ATOM 10869 CA GLY G 136 30.777 38.199 184.840 1.00 24.98 C +ATOM 10870 C GLY G 136 30.097 36.864 185.109 1.00 27.32 C +ATOM 10871 O GLY G 136 30.484 35.860 184.512 1.00 27.37 O +ATOM 10872 N GLN G 137 29.144 36.825 186.038 1.00 21.45 N +ATOM 10873 CA GLN G 137 28.433 35.598 186.347 1.00 15.00 C +ATOM 10874 C GLN G 137 26.931 35.831 186.349 1.00 19.25 C +ATOM 10875 O GLN G 137 26.467 36.961 186.518 1.00 17.33 O +ATOM 10876 CB GLN G 137 28.866 35.045 187.694 1.00 9.99 C +ATOM 10877 CG GLN G 137 30.147 34.250 187.680 1.00 8.50 C +ATOM 10878 CD GLN G 137 30.159 33.132 186.650 1.00 15.64 C +ATOM 10879 OE1 GLN G 137 31.231 32.672 186.259 1.00 9.89 O +ATOM 10880 NE2 GLN G 137 28.969 32.670 186.220 1.00 8.50 N +ATOM 10881 N GLU G 138 26.169 34.757 186.167 1.00 24.18 N +ATOM 10882 CA GLU G 138 24.716 34.873 186.149 1.00 25.24 C +ATOM 10883 C GLU G 138 24.120 34.440 187.477 1.00 26.24 C +ATOM 10884 O GLU G 138 24.153 33.254 187.829 1.00 29.08 O +ATOM 10885 CB GLU G 138 24.122 34.027 185.014 1.00 28.25 C +ATOM 10886 CG GLU G 138 22.762 34.515 184.503 1.00 27.68 C +ATOM 10887 CD GLU G 138 21.622 34.345 185.493 1.00 26.86 C +ATOM 10888 OE1 GLU G 138 20.990 33.280 185.465 1.00 34.49 O +ATOM 10889 OE2 GLU G 138 21.332 35.282 186.271 1.00 31.17 O +ATOM 10890 N GLN G 139 23.573 35.405 188.206 1.00 27.94 N +ATOM 10891 CA GLN G 139 22.948 35.128 189.500 1.00 33.22 C +ATOM 10892 C GLN G 139 21.585 34.428 189.403 1.00 35.56 C +ATOM 10893 O GLN G 139 20.699 34.822 188.631 1.00 29.86 O +ATOM 10894 CB GLN G 139 22.795 36.413 190.326 1.00 26.36 C +ATOM 10895 CG GLN G 139 23.924 36.658 191.288 1.00 20.11 C +ATOM 10896 CD GLN G 139 23.969 38.111 191.708 1.00 36.43 C +ATOM 10897 OE1 GLN G 139 24.626 38.928 191.062 1.00 38.65 O +ATOM 10898 NE2 GLN G 139 23.239 38.454 192.768 1.00 35.85 N +ATOM 10899 N ASP G 140 21.438 33.394 190.219 1.00 39.40 N +ATOM 10900 CA ASP G 140 20.203 32.637 190.294 1.00 46.12 C +ATOM 10901 C ASP G 140 19.772 32.517 191.757 1.00 47.97 C +ATOM 10902 O ASP G 140 18.827 31.797 192.102 1.00 51.25 O +ATOM 10903 CB ASP G 140 20.365 31.278 189.612 1.00 47.59 C +ATOM 10904 CG ASP G 140 20.441 31.403 188.104 1.00 45.16 C +ATOM 10905 OD1 ASP G 140 19.669 32.219 187.549 1.00 48.41 O +ATOM 10906 OD2 ASP G 140 21.274 30.712 187.481 1.00 36.34 O +ATOM 10907 N SER G 141 20.477 33.263 192.601 1.00 45.13 N +ATOM 10908 CA SER G 141 20.211 33.346 194.025 1.00 44.61 C +ATOM 10909 C SER G 141 21.029 34.547 194.489 1.00 40.45 C +ATOM 10910 O SER G 141 22.052 34.883 193.869 1.00 40.00 O +ATOM 10911 CB SER G 141 20.662 32.069 194.754 1.00 53.75 C +ATOM 10912 OG SER G 141 22.060 32.058 195.004 1.00 55.22 O +ATOM 10913 N PHE G 142 20.575 35.206 195.549 1.00 33.92 N +ATOM 10914 CA PHE G 142 21.270 36.370 196.065 1.00 33.25 C +ATOM 10915 C PHE G 142 22.765 36.104 196.277 1.00 34.90 C +ATOM 10916 O PHE G 142 23.157 35.444 197.233 1.00 39.33 O +ATOM 10917 CB PHE G 142 20.621 36.818 197.367 1.00 37.78 C +ATOM 10918 CG PHE G 142 21.048 38.177 197.830 1.00 37.04 C +ATOM 10919 CD1 PHE G 142 20.357 39.302 197.405 1.00 40.33 C +ATOM 10920 CD2 PHE G 142 22.110 38.331 198.730 1.00 43.21 C +ATOM 10921 CE1 PHE G 142 20.701 40.579 197.869 1.00 57.99 C +ATOM 10922 CE2 PHE G 142 22.473 39.601 199.208 1.00 56.03 C +ATOM 10923 CZ PHE G 142 21.765 40.733 198.777 1.00 61.03 C +ATOM 10924 N GLY G 143 23.581 36.587 195.343 1.00 38.08 N +ATOM 10925 CA GLY G 143 25.024 36.436 195.441 1.00 33.64 C +ATOM 10926 C GLY G 143 25.605 35.078 195.101 1.00 35.90 C +ATOM 10927 O GLY G 143 26.778 34.824 195.403 1.00 31.32 O +ATOM 10928 N GLY G 144 24.822 34.223 194.443 1.00 37.10 N +ATOM 10929 CA GLY G 144 25.321 32.900 194.095 1.00 40.43 C +ATOM 10930 C GLY G 144 24.519 32.123 193.062 1.00 44.77 C +ATOM 10931 O GLY G 144 23.674 32.684 192.341 1.00 45.70 O +ATOM 10932 N ASN G 145 24.784 30.817 193.013 1.00 46.57 N +ATOM 10933 CA ASN G 145 24.136 29.896 192.078 1.00 49.08 C +ATOM 10934 C ASN G 145 24.515 30.246 190.655 1.00 45.28 C +ATOM 10935 O ASN G 145 23.668 30.482 189.796 1.00 49.69 O +ATOM 10936 CB ASN G 145 22.617 29.894 192.260 1.00 60.13 C +ATOM 10937 CG ASN G 145 22.175 29.005 193.408 1.00 74.48 C +ATOM 10938 OD1 ASN G 145 22.545 29.231 194.564 1.00 81.35 O +ATOM 10939 ND2 ASN G 145 21.388 27.978 193.095 1.00 81.73 N +ATOM 10940 N PHE G 146 25.814 30.233 190.407 1.00 43.15 N +ATOM 10941 CA PHE G 146 26.357 30.578 189.098 1.00 45.72 C +ATOM 10942 C PHE G 146 26.413 29.416 188.095 1.00 48.45 C +ATOM 10943 O PHE G 146 26.995 28.358 188.377 1.00 51.72 O +ATOM 10944 CB PHE G 146 27.769 31.159 189.273 1.00 38.83 C +ATOM 10945 CG PHE G 146 27.839 32.304 190.240 1.00 25.30 C +ATOM 10946 CD1 PHE G 146 26.827 33.267 190.273 1.00 19.26 C +ATOM 10947 CD2 PHE G 146 28.930 32.438 191.097 1.00 15.54 C +ATOM 10948 CE1 PHE G 146 26.909 34.355 191.148 1.00 23.45 C +ATOM 10949 CE2 PHE G 146 29.024 33.513 191.971 1.00 16.06 C +ATOM 10950 CZ PHE G 146 28.019 34.478 192.002 1.00 16.37 C +ATOM 10951 N GLU G 147 25.802 29.609 186.929 1.00 46.89 N +ATOM 10952 CA GLU G 147 25.857 28.590 185.886 1.00 48.61 C +ATOM 10953 C GLU G 147 27.000 28.999 184.935 1.00 50.45 C +ATOM 10954 O GLU G 147 26.996 30.114 184.374 1.00 54.75 O +ATOM 10955 CB GLU G 147 24.511 28.487 185.163 1.00 49.66 C +ATOM 10956 CG GLU G 147 24.164 27.087 184.676 1.00 61.03 C +ATOM 10957 CD GLU G 147 22.659 26.847 184.647 1.00 71.81 C +ATOM 10958 OE1 GLU G 147 22.054 26.705 185.736 1.00 70.99 O +ATOM 10959 OE2 GLU G 147 22.074 26.804 183.539 1.00 85.67 O +ATOM 10960 N GLY G 148 27.999 28.119 184.814 1.00 47.55 N +ATOM 10961 CA GLY G 148 29.165 28.370 183.974 1.00 45.77 C +ATOM 10962 C GLY G 148 28.887 28.554 182.493 1.00 45.28 C +ATOM 10963 O GLY G 148 29.726 29.081 181.750 1.00 47.00 O +ATOM 10964 N SER G 149 27.704 28.119 182.074 1.00 41.98 N +ATOM 10965 CA SER G 149 27.252 28.233 180.692 1.00 42.12 C +ATOM 10966 C SER G 149 26.766 29.673 180.396 1.00 38.58 C +ATOM 10967 O SER G 149 26.360 29.999 179.279 1.00 43.07 O +ATOM 10968 CB SER G 149 26.115 27.229 180.470 1.00 50.19 C +ATOM 10969 OG SER G 149 25.711 27.152 179.115 1.00 66.94 O +ATOM 10970 N GLN G 150 26.810 30.529 181.407 1.00 28.27 N +ATOM 10971 CA GLN G 150 26.374 31.902 181.276 1.00 21.23 C +ATOM 10972 C GLN G 150 27.431 32.859 181.839 1.00 27.47 C +ATOM 10973 O GLN G 150 27.136 34.013 182.166 1.00 31.89 O +ATOM 10974 CB GLN G 150 25.052 32.075 182.013 1.00 18.41 C +ATOM 10975 CG GLN G 150 24.023 31.008 181.667 1.00 23.21 C +ATOM 10976 CD GLN G 150 22.630 31.327 182.205 1.00 33.32 C +ATOM 10977 OE1 GLN G 150 22.444 31.577 183.394 1.00 37.27 O +ATOM 10978 NE2 GLN G 150 21.643 31.303 181.325 1.00 40.73 N +ATOM 10979 N SER G 151 28.659 32.372 181.960 1.00 24.65 N +ATOM 10980 CA SER G 151 29.738 33.185 182.471 1.00 22.49 C +ATOM 10981 C SER G 151 30.255 34.062 181.339 1.00 26.29 C +ATOM 10982 O SER G 151 30.031 33.769 180.162 1.00 30.31 O +ATOM 10983 CB SER G 151 30.865 32.298 182.992 1.00 30.87 C +ATOM 10984 OG SER G 151 31.907 33.069 183.579 1.00 54.73 O +ATOM 10985 N LEU G 152 30.922 35.161 181.683 1.00 25.03 N +ATOM 10986 CA LEU G 152 31.466 36.032 180.654 1.00 15.70 C +ATOM 10987 C LEU G 152 32.965 35.797 180.500 1.00 12.18 C +ATOM 10988 O LEU G 152 33.698 35.731 181.483 1.00 14.12 O +ATOM 10989 CB LEU G 152 31.200 37.508 180.995 1.00 12.61 C +ATOM 10990 CG LEU G 152 31.922 38.519 180.096 1.00 18.33 C +ATOM 10991 CD1 LEU G 152 31.185 38.682 178.783 1.00 16.06 C +ATOM 10992 CD2 LEU G 152 32.027 39.845 180.788 1.00 11.17 C +ATOM 10993 N VAL G 153 33.411 35.662 179.263 1.00 10.12 N +ATOM 10994 CA VAL G 153 34.826 35.476 178.995 1.00 12.24 C +ATOM 10995 C VAL G 153 35.241 36.620 178.075 1.00 14.83 C +ATOM 10996 O VAL G 153 34.834 36.685 176.908 1.00 11.17 O +ATOM 10997 CB VAL G 153 35.113 34.138 178.306 1.00 15.48 C +ATOM 10998 CG1 VAL G 153 36.610 33.872 178.305 1.00 12.36 C +ATOM 10999 CG2 VAL G 153 34.344 33.027 178.975 1.00 11.07 C +ATOM 11000 N GLY G 154 36.008 37.543 178.637 1.00 14.76 N +ATOM 11001 CA GLY G 154 36.474 38.704 177.903 1.00 14.15 C +ATOM 11002 C GLY G 154 36.677 39.867 178.861 1.00 14.09 C +ATOM 11003 O GLY G 154 36.939 39.655 180.042 1.00 13.27 O +ATOM 11004 N ASP G 155 36.547 41.092 178.365 1.00 11.01 N +ATOM 11005 CA ASP G 155 36.723 42.268 179.202 1.00 9.68 C +ATOM 11006 C ASP G 155 35.409 42.995 179.419 1.00 9.41 C +ATOM 11007 O ASP G 155 34.527 42.978 178.560 1.00 13.53 O +ATOM 11008 CB ASP G 155 37.677 43.254 178.546 1.00 11.59 C +ATOM 11009 CG ASP G 155 39.084 42.753 178.480 1.00 13.20 C +ATOM 11010 OD1 ASP G 155 39.295 41.653 177.905 1.00 11.23 O +ATOM 11011 OD2 ASP G 155 39.974 43.491 178.978 1.00 11.29 O +ATOM 11012 N ILE G 156 35.296 43.661 180.555 1.00 8.50 N +ATOM 11013 CA ILE G 156 34.118 44.441 180.852 1.00 8.50 C +ATOM 11014 C ILE G 156 34.620 45.604 181.683 1.00 12.74 C +ATOM 11015 O ILE G 156 35.503 45.440 182.530 1.00 15.77 O +ATOM 11016 CB ILE G 156 33.055 43.650 181.607 1.00 8.50 C +ATOM 11017 CG1 ILE G 156 31.834 44.529 181.845 1.00 8.52 C +ATOM 11018 CG2 ILE G 156 33.579 43.193 182.929 1.00 15.87 C +ATOM 11019 CD1 ILE G 156 30.704 43.802 182.498 1.00 9.47 C +ATOM 11020 N GLY G 157 34.108 46.794 181.399 1.00 12.44 N +ATOM 11021 CA GLY G 157 34.553 47.965 182.120 1.00 9.28 C +ATOM 11022 C GLY G 157 33.611 49.122 181.910 1.00 11.67 C +ATOM 11023 O GLY G 157 32.570 48.992 181.255 1.00 11.39 O +ATOM 11024 N ASN G 158 33.992 50.264 182.468 1.00 15.24 N +ATOM 11025 CA ASN G 158 33.201 51.492 182.403 1.00 11.59 C +ATOM 11026 C ASN G 158 31.746 51.339 182.790 1.00 10.21 C +ATOM 11027 O ASN G 158 30.870 51.895 182.128 1.00 14.08 O +ATOM 11028 CB ASN G 158 33.303 52.145 181.025 1.00 18.74 C +ATOM 11029 CG ASN G 158 34.519 53.029 180.902 1.00 25.24 C +ATOM 11030 OD1 ASN G 158 35.346 52.852 180.007 1.00 31.08 O +ATOM 11031 ND2 ASN G 158 34.647 53.980 181.813 1.00 29.01 N +ATOM 11032 N VAL G 159 31.484 50.585 183.852 1.00 9.93 N +ATOM 11033 CA VAL G 159 30.110 50.403 184.299 1.00 14.29 C +ATOM 11034 C VAL G 159 29.736 51.570 185.227 1.00 12.43 C +ATOM 11035 O VAL G 159 30.529 51.955 186.101 1.00 10.92 O +ATOM 11036 CB VAL G 159 29.844 48.981 184.952 1.00 15.03 C +ATOM 11037 CG1 VAL G 159 31.133 48.209 185.151 1.00 8.50 C +ATOM 11038 CG2 VAL G 159 29.061 49.104 186.262 1.00 15.04 C +ATOM 11039 N ASN G 160 28.588 52.190 184.944 1.00 8.50 N +ATOM 11040 CA ASN G 160 28.083 53.314 185.716 1.00 11.18 C +ATOM 11041 C ASN G 160 26.576 53.131 185.787 1.00 14.50 C +ATOM 11042 O ASN G 160 25.997 52.476 184.912 1.00 13.77 O +ATOM 11043 CB ASN G 160 28.411 54.654 185.048 1.00 11.42 C +ATOM 11044 CG ASN G 160 29.909 54.933 184.977 1.00 16.85 C +ATOM 11045 OD1 ASN G 160 30.542 54.706 183.948 1.00 31.93 O +ATOM 11046 ND2 ASN G 160 30.475 55.451 186.057 1.00 8.50 N +ATOM 11047 N MET G 161 25.940 53.718 186.805 1.00 10.76 N +ATOM 11048 CA MET G 161 24.507 53.570 186.989 1.00 9.74 C +ATOM 11049 C MET G 161 23.920 54.792 187.646 1.00 10.64 C +ATOM 11050 O MET G 161 24.495 55.328 188.589 1.00 13.37 O +ATOM 11051 CB MET G 161 24.225 52.337 187.853 1.00 13.60 C +ATOM 11052 CG MET G 161 22.756 52.021 188.051 1.00 20.79 C +ATOM 11053 SD MET G 161 22.534 50.409 188.793 1.00 26.25 S +ATOM 11054 CE MET G 161 20.747 50.182 188.598 1.00 13.49 C +ATOM 11055 N TRP G 162 22.789 55.244 187.120 1.00 11.31 N +ATOM 11056 CA TRP G 162 22.094 56.412 187.642 1.00 12.37 C +ATOM 11057 C TRP G 162 20.736 55.933 188.119 1.00 14.17 C +ATOM 11058 O TRP G 162 20.234 54.907 187.648 1.00 16.52 O +ATOM 11059 CB TRP G 162 21.877 57.456 186.537 1.00 14.89 C +ATOM 11060 CG TRP G 162 23.128 58.063 185.971 1.00 11.61 C +ATOM 11061 CD1 TRP G 162 23.593 59.315 186.200 1.00 12.06 C +ATOM 11062 CD2 TRP G 162 24.027 57.468 185.017 1.00 15.93 C +ATOM 11063 NE1 TRP G 162 24.718 59.553 185.447 1.00 18.93 N +ATOM 11064 CE2 TRP G 162 25.008 58.432 184.713 1.00 18.69 C +ATOM 11065 CE3 TRP G 162 24.095 56.216 184.391 1.00 18.51 C +ATOM 11066 CZ2 TRP G 162 26.052 58.184 183.807 1.00 15.62 C +ATOM 11067 CZ3 TRP G 162 25.133 55.973 183.493 1.00 14.76 C +ATOM 11068 CH2 TRP G 162 26.094 56.951 183.213 1.00 10.90 C +ATOM 11069 N ASP G 163 20.128 56.668 189.043 1.00 13.49 N +ATOM 11070 CA ASP G 163 18.805 56.284 189.543 1.00 13.62 C +ATOM 11071 C ASP G 163 17.675 56.966 188.781 1.00 17.05 C +ATOM 11072 O ASP G 163 16.513 56.933 189.219 1.00 18.54 O +ATOM 11073 CB ASP G 163 18.667 56.534 191.059 1.00 19.29 C +ATOM 11074 CG ASP G 163 18.756 58.027 191.457 1.00 34.55 C +ATOM 11075 OD1 ASP G 163 18.419 58.941 190.656 1.00 31.34 O +ATOM 11076 OD2 ASP G 163 19.143 58.286 192.622 1.00 46.07 O +ATOM 11077 N PHE G 164 18.036 57.638 187.682 1.00 13.08 N +ATOM 11078 CA PHE G 164 17.065 58.333 186.840 1.00 11.74 C +ATOM 11079 C PHE G 164 17.383 58.012 185.378 1.00 12.60 C +ATOM 11080 O PHE G 164 18.426 57.418 185.082 1.00 13.21 O +ATOM 11081 CB PHE G 164 17.072 59.846 187.111 1.00 13.63 C +ATOM 11082 CG PHE G 164 18.387 60.523 186.814 1.00 12.92 C +ATOM 11083 CD1 PHE G 164 19.387 60.579 187.774 1.00 14.66 C +ATOM 11084 CD2 PHE G 164 18.618 61.122 185.571 1.00 12.77 C +ATOM 11085 CE1 PHE G 164 20.602 61.222 187.506 1.00 15.19 C +ATOM 11086 CE2 PHE G 164 19.823 61.760 185.297 1.00 8.60 C +ATOM 11087 CZ PHE G 164 20.816 61.810 186.266 1.00 9.83 C +ATOM 11088 N VAL G 165 16.500 58.416 184.467 1.00 14.73 N +ATOM 11089 CA VAL G 165 16.691 58.138 183.045 1.00 10.16 C +ATOM 11090 C VAL G 165 17.470 59.222 182.298 1.00 11.62 C +ATOM 11091 O VAL G 165 17.018 60.373 182.186 1.00 14.43 O +ATOM 11092 CB VAL G 165 15.335 57.916 182.336 1.00 8.50 C +ATOM 11093 CG1 VAL G 165 15.544 57.476 180.919 1.00 14.76 C +ATOM 11094 CG2 VAL G 165 14.523 56.868 183.076 1.00 22.16 C +ATOM 11095 N LEU G 166 18.639 58.843 181.790 1.00 11.64 N +ATOM 11096 CA LEU G 166 19.481 59.740 181.012 1.00 9.96 C +ATOM 11097 C LEU G 166 18.782 60.144 179.702 1.00 9.67 C +ATOM 11098 O LEU G 166 18.067 59.347 179.067 1.00 9.39 O +ATOM 11099 CB LEU G 166 20.802 59.056 180.682 1.00 8.50 C +ATOM 11100 CG LEU G 166 22.015 59.439 181.505 1.00 8.50 C +ATOM 11101 CD1 LEU G 166 21.672 59.335 182.944 1.00 14.10 C +ATOM 11102 CD2 LEU G 166 23.166 58.527 181.151 1.00 12.21 C +ATOM 11103 N SER G 167 18.992 61.392 179.305 1.00 9.21 N +ATOM 11104 CA SER G 167 18.395 61.892 178.078 1.00 17.42 C +ATOM 11105 C SER G 167 19.297 61.509 176.914 1.00 18.29 C +ATOM 11106 O SER G 167 20.454 61.105 177.117 1.00 16.98 O +ATOM 11107 CB SER G 167 18.214 63.426 178.125 1.00 24.16 C +ATOM 11108 OG SER G 167 19.451 64.115 178.036 1.00 23.80 O +ATOM 11109 N PRO G 168 18.784 61.635 175.675 1.00 14.62 N +ATOM 11110 CA PRO G 168 19.572 61.297 174.496 1.00 13.34 C +ATOM 11111 C PRO G 168 20.906 62.068 174.455 1.00 16.81 C +ATOM 11112 O PRO G 168 21.950 61.519 174.091 1.00 18.11 O +ATOM 11113 CB PRO G 168 18.633 61.709 173.357 1.00 14.96 C +ATOM 11114 CG PRO G 168 17.305 61.408 173.900 1.00 8.50 C +ATOM 11115 CD PRO G 168 17.402 61.975 175.289 1.00 15.48 C +ATOM 11116 N ASP G 169 20.868 63.333 174.859 1.00 16.15 N +ATOM 11117 CA ASP G 169 22.067 64.158 174.843 1.00 18.11 C +ATOM 11118 C ASP G 169 23.076 63.684 175.878 1.00 15.41 C +ATOM 11119 O ASP G 169 24.282 63.644 175.618 1.00 17.39 O +ATOM 11120 CB ASP G 169 21.704 65.638 175.072 1.00 33.91 C +ATOM 11121 CG ASP G 169 20.771 66.195 173.987 1.00 40.83 C +ATOM 11122 OD1 ASP G 169 21.193 66.268 172.805 1.00 44.09 O +ATOM 11123 OD2 ASP G 169 19.619 66.562 174.323 1.00 46.48 O +ATOM 11124 N GLU G 170 22.578 63.317 177.054 1.00 12.34 N +ATOM 11125 CA GLU G 170 23.451 62.842 178.118 1.00 10.78 C +ATOM 11126 C GLU G 170 24.029 61.511 177.677 1.00 10.84 C +ATOM 11127 O GLU G 170 25.241 61.343 177.636 1.00 12.42 O +ATOM 11128 CB GLU G 170 22.672 62.696 179.424 1.00 12.44 C +ATOM 11129 CG GLU G 170 21.956 63.985 179.848 1.00 27.46 C +ATOM 11130 CD GLU G 170 21.241 63.872 181.195 1.00 37.78 C +ATOM 11131 OE1 GLU G 170 21.929 63.714 182.233 1.00 44.89 O +ATOM 11132 OE2 GLU G 170 19.992 63.960 181.219 1.00 36.81 O +ATOM 11133 N ILE G 171 23.161 60.600 177.245 1.00 12.84 N +ATOM 11134 CA ILE G 171 23.604 59.275 176.784 1.00 14.85 C +ATOM 11135 C ILE G 171 24.656 59.431 175.704 1.00 13.79 C +ATOM 11136 O ILE G 171 25.571 58.618 175.574 1.00 11.34 O +ATOM 11137 CB ILE G 171 22.420 58.430 176.245 1.00 13.29 C +ATOM 11138 CG1 ILE G 171 21.547 58.012 177.424 1.00 16.89 C +ATOM 11139 CG2 ILE G 171 22.913 57.213 175.492 1.00 8.50 C +ATOM 11140 CD1 ILE G 171 20.372 57.177 177.068 1.00 28.37 C +ATOM 11141 N ASN G 172 24.545 60.521 174.963 1.00 17.87 N +ATOM 11142 CA ASN G 172 25.489 60.772 173.912 1.00 20.52 C +ATOM 11143 C ASN G 172 26.830 61.190 174.473 1.00 14.12 C +ATOM 11144 O ASN G 172 27.839 60.626 174.081 1.00 18.46 O +ATOM 11145 CB ASN G 172 24.960 61.813 172.926 1.00 34.81 C +ATOM 11146 CG ASN G 172 25.872 61.977 171.738 1.00 43.38 C +ATOM 11147 OD1 ASN G 172 26.631 62.944 171.648 1.00 50.29 O +ATOM 11148 ND2 ASN G 172 25.849 60.998 170.847 1.00 46.32 N +ATOM 11149 N THR G 173 26.855 62.151 175.397 1.00 10.33 N +ATOM 11150 CA THR G 173 28.145 62.564 175.945 1.00 12.75 C +ATOM 11151 C THR G 173 28.809 61.382 176.674 1.00 11.58 C +ATOM 11152 O THR G 173 30.018 61.199 176.564 1.00 13.49 O +ATOM 11153 CB THR G 173 28.075 63.818 176.873 1.00 18.96 C +ATOM 11154 OG1 THR G 173 27.859 63.407 178.226 1.00 32.74 O +ATOM 11155 CG2 THR G 173 26.952 64.781 176.441 1.00 16.95 C +ATOM 11156 N ILE G 174 28.032 60.561 177.382 1.00 10.36 N +ATOM 11157 CA ILE G 174 28.619 59.411 178.061 1.00 9.63 C +ATOM 11158 C ILE G 174 29.373 58.590 177.016 1.00 9.30 C +ATOM 11159 O ILE G 174 30.528 58.207 177.228 1.00 10.45 O +ATOM 11160 CB ILE G 174 27.561 58.502 178.737 1.00 12.59 C +ATOM 11161 CG1 ILE G 174 27.168 59.059 180.092 1.00 11.38 C +ATOM 11162 CG2 ILE G 174 28.127 57.110 178.979 1.00 11.15 C +ATOM 11163 CD1 ILE G 174 26.222 60.196 180.031 1.00 17.65 C +ATOM 11164 N TYR G 175 28.729 58.356 175.878 1.00 8.50 N +ATOM 11165 CA TYR G 175 29.350 57.576 174.809 1.00 12.89 C +ATOM 11166 C TYR G 175 30.623 58.208 174.257 1.00 18.19 C +ATOM 11167 O TYR G 175 31.665 57.548 174.134 1.00 23.26 O +ATOM 11168 CB TYR G 175 28.371 57.346 173.648 1.00 12.27 C +ATOM 11169 CG TYR G 175 28.994 56.635 172.472 1.00 8.50 C +ATOM 11170 CD1 TYR G 175 29.703 55.444 172.647 1.00 16.42 C +ATOM 11171 CD2 TYR G 175 28.878 57.146 171.189 1.00 14.34 C +ATOM 11172 CE1 TYR G 175 30.277 54.780 171.571 1.00 24.55 C +ATOM 11173 CE2 TYR G 175 29.447 56.493 170.093 1.00 22.22 C +ATOM 11174 CZ TYR G 175 30.143 55.309 170.289 1.00 29.72 C +ATOM 11175 OH TYR G 175 30.691 54.638 169.213 1.00 37.47 O +ATOM 11176 N LEU G 176 30.503 59.481 173.896 1.00 21.43 N +ATOM 11177 CA LEU G 176 31.596 60.265 173.332 1.00 21.52 C +ATOM 11178 C LEU G 176 32.729 60.615 174.292 1.00 24.13 C +ATOM 11179 O LEU G 176 33.734 61.183 173.872 1.00 24.31 O +ATOM 11180 CB LEU G 176 31.040 61.544 172.725 1.00 20.94 C +ATOM 11181 CG LEU G 176 30.951 61.598 171.212 1.00 19.83 C +ATOM 11182 CD1 LEU G 176 30.958 60.201 170.607 1.00 29.87 C +ATOM 11183 CD2 LEU G 176 29.704 62.361 170.848 1.00 23.87 C +ATOM 11184 N GLY G 177 32.554 60.296 175.571 1.00 26.50 N +ATOM 11185 CA GLY G 177 33.583 60.578 176.549 1.00 32.63 C +ATOM 11186 C GLY G 177 33.513 62.005 177.049 1.00 39.01 C +ATOM 11187 O GLY G 177 34.465 62.783 176.902 1.00 47.64 O +ATOM 11188 N GLY G 178 32.353 62.380 177.579 1.00 41.97 N +ATOM 11189 CA GLY G 178 32.196 63.719 178.117 1.00 38.19 C +ATOM 11190 C GLY G 178 32.241 63.566 179.620 1.00 39.42 C +ATOM 11191 O GLY G 178 32.519 62.465 180.126 1.00 42.24 O +ATOM 11192 N PRO G 179 32.061 64.657 180.367 1.00 35.19 N +ATOM 11193 CA PRO G 179 32.082 64.576 181.831 1.00 35.84 C +ATOM 11194 C PRO G 179 30.658 64.402 182.363 1.00 33.73 C +ATOM 11195 O PRO G 179 29.716 65.021 181.847 1.00 33.56 O +ATOM 11196 CB PRO G 179 32.684 65.911 182.224 1.00 39.38 C +ATOM 11197 CG PRO G 179 32.102 66.831 181.194 1.00 35.12 C +ATOM 11198 CD PRO G 179 32.172 66.047 179.905 1.00 31.30 C +ATOM 11199 N PHE G 180 30.506 63.550 183.379 1.00 32.14 N +ATOM 11200 CA PHE G 180 29.200 63.273 183.983 1.00 30.06 C +ATOM 11201 C PHE G 180 29.403 62.726 185.388 1.00 28.32 C +ATOM 11202 O PHE G 180 30.519 62.347 185.753 1.00 27.79 O +ATOM 11203 CB PHE G 180 28.431 62.250 183.137 1.00 29.10 C +ATOM 11204 CG PHE G 180 29.230 61.020 182.816 1.00 34.89 C +ATOM 11205 CD1 PHE G 180 30.066 60.986 181.696 1.00 41.10 C +ATOM 11206 CD2 PHE G 180 29.192 59.909 183.659 1.00 39.40 C +ATOM 11207 CE1 PHE G 180 30.864 59.863 181.417 1.00 40.87 C +ATOM 11208 CE2 PHE G 180 29.985 58.778 183.393 1.00 45.89 C +ATOM 11209 CZ PHE G 180 30.825 58.759 182.266 1.00 44.95 C +ATOM 11210 N SER G 181 28.319 62.666 186.155 1.00 27.83 N +ATOM 11211 CA SER G 181 28.378 62.157 187.515 1.00 31.72 C +ATOM 11212 C SER G 181 27.258 61.163 187.845 1.00 30.71 C +ATOM 11213 O SER G 181 26.096 61.558 188.031 1.00 37.90 O +ATOM 11214 CB SER G 181 28.361 63.314 188.522 1.00 38.95 C +ATOM 11215 OG SER G 181 29.603 63.417 189.203 1.00 58.85 O +ATOM 11216 N PRO G 182 27.589 59.853 187.876 1.00 23.65 N +ATOM 11217 CA PRO G 182 26.621 58.795 188.190 1.00 22.30 C +ATOM 11218 C PRO G 182 26.234 58.977 189.651 1.00 25.77 C +ATOM 11219 O PRO G 182 26.952 59.649 190.407 1.00 29.69 O +ATOM 11220 CB PRO G 182 27.447 57.520 188.032 1.00 25.82 C +ATOM 11221 CG PRO G 182 28.549 57.929 187.083 1.00 23.72 C +ATOM 11222 CD PRO G 182 28.912 59.278 187.579 1.00 14.81 C +ATOM 11223 N ASN G 183 25.126 58.378 190.072 1.00 25.32 N +ATOM 11224 CA ASN G 183 24.721 58.524 191.468 1.00 18.31 C +ATOM 11225 C ASN G 183 24.289 57.229 192.134 1.00 17.03 C +ATOM 11226 O ASN G 183 23.525 57.245 193.098 1.00 26.88 O +ATOM 11227 CB ASN G 183 23.654 59.621 191.627 1.00 14.33 C +ATOM 11228 CG ASN G 183 22.316 59.242 191.037 1.00 8.50 C +ATOM 11229 OD1 ASN G 183 22.178 58.255 190.311 1.00 9.90 O +ATOM 11230 ND2 ASN G 183 21.315 60.040 191.346 1.00 11.38 N +ATOM 11231 N VAL G 184 24.761 56.111 191.596 1.00 13.00 N +ATOM 11232 CA VAL G 184 24.476 54.788 192.151 1.00 13.14 C +ATOM 11233 C VAL G 184 25.787 54.010 192.036 1.00 14.36 C +ATOM 11234 O VAL G 184 26.412 53.690 193.042 1.00 22.32 O +ATOM 11235 CB VAL G 184 23.343 54.030 191.393 1.00 12.85 C +ATOM 11236 CG1 VAL G 184 23.154 52.635 191.990 1.00 8.50 C +ATOM 11237 CG2 VAL G 184 22.049 54.811 191.449 1.00 9.69 C +ATOM 11238 N LEU G 185 26.219 53.748 190.807 1.00 10.86 N +ATOM 11239 CA LEU G 185 27.470 53.044 190.569 1.00 11.42 C +ATOM 11240 C LEU G 185 28.345 54.040 189.837 1.00 15.79 C +ATOM 11241 O LEU G 185 27.888 54.670 188.875 1.00 17.40 O +ATOM 11242 CB LEU G 185 27.231 51.811 189.709 1.00 12.72 C +ATOM 11243 CG LEU G 185 27.458 50.461 190.391 1.00 22.20 C +ATOM 11244 CD1 LEU G 185 26.716 50.415 191.704 1.00 19.64 C +ATOM 11245 CD2 LEU G 185 26.983 49.323 189.487 1.00 29.75 C +ATOM 11246 N ASN G 186 29.569 54.232 190.319 1.00 17.13 N +ATOM 11247 CA ASN G 186 30.488 55.195 189.717 1.00 15.16 C +ATOM 11248 C ASN G 186 31.833 54.522 189.444 1.00 18.79 C +ATOM 11249 O ASN G 186 32.542 54.150 190.382 1.00 22.67 O +ATOM 11250 CB ASN G 186 30.679 56.385 190.668 1.00 16.24 C +ATOM 11251 CG ASN G 186 31.492 57.506 190.054 1.00 17.85 C +ATOM 11252 OD1 ASN G 186 32.334 57.288 189.176 1.00 17.37 O +ATOM 11253 ND2 ASN G 186 31.248 58.719 190.518 1.00 26.39 N +ATOM 11254 N TRP G 187 32.195 54.397 188.165 1.00 15.31 N +ATOM 11255 CA TRP G 187 33.439 53.752 187.779 1.00 10.06 C +ATOM 11256 C TRP G 187 34.675 54.500 188.303 1.00 14.13 C +ATOM 11257 O TRP G 187 35.772 53.934 188.394 1.00 18.55 O +ATOM 11258 CB TRP G 187 33.478 53.599 186.256 1.00 8.50 C +ATOM 11259 CG TRP G 187 34.512 52.621 185.774 1.00 13.85 C +ATOM 11260 CD1 TRP G 187 35.647 52.907 185.071 1.00 10.78 C +ATOM 11261 CD2 TRP G 187 34.500 51.194 185.949 1.00 15.18 C +ATOM 11262 NE1 TRP G 187 36.338 51.749 184.796 1.00 15.49 N +ATOM 11263 CE2 TRP G 187 35.655 50.685 185.317 1.00 8.50 C +ATOM 11264 CE3 TRP G 187 33.622 50.298 186.577 1.00 13.48 C +ATOM 11265 CZ2 TRP G 187 35.952 49.332 185.288 1.00 8.50 C +ATOM 11266 CZ3 TRP G 187 33.924 48.945 186.550 1.00 10.03 C +ATOM 11267 CH2 TRP G 187 35.078 48.479 185.907 1.00 10.84 C +ATOM 11268 N ARG G 188 34.498 55.770 188.648 1.00 11.31 N +ATOM 11269 CA ARG G 188 35.588 56.595 189.155 1.00 21.04 C +ATOM 11270 C ARG G 188 35.804 56.397 190.660 1.00 28.41 C +ATOM 11271 O ARG G 188 36.873 56.726 191.207 1.00 32.25 O +ATOM 11272 CB ARG G 188 35.252 58.069 188.906 1.00 33.83 C +ATOM 11273 CG ARG G 188 36.046 58.737 187.801 1.00 60.73 C +ATOM 11274 CD ARG G 188 35.401 58.548 186.438 1.00 85.97 C +ATOM 11275 NE ARG G 188 36.347 58.837 185.354 1.00105.84 N +ATOM 11276 CZ ARG G 188 36.148 58.545 184.067 1.00108.48 C +ATOM 11277 NH1 ARG G 188 35.024 57.955 183.662 1.00107.03 N +ATOM 11278 NH2 ARG G 188 37.112 58.789 183.186 1.00110.48 N +ATOM 11279 N ALA G 189 34.771 55.890 191.331 1.00 28.38 N +ATOM 11280 CA ALA G 189 34.808 55.652 192.775 1.00 22.26 C +ATOM 11281 C ALA G 189 34.097 54.329 192.984 1.00 22.00 C +ATOM 11282 O ALA G 189 33.084 54.260 193.690 1.00 26.37 O +ATOM 11283 CB ALA G 189 34.066 56.773 193.504 1.00 17.29 C +ATOM 11284 N LEU G 190 34.613 53.290 192.332 1.00 18.74 N +ATOM 11285 CA LEU G 190 34.019 51.964 192.403 1.00 22.53 C +ATOM 11286 C LEU G 190 34.439 51.248 193.686 1.00 27.09 C +ATOM 11287 O LEU G 190 35.589 51.389 194.140 1.00 29.44 O +ATOM 11288 CB LEU G 190 34.411 51.134 191.170 1.00 10.62 C +ATOM 11289 CG LEU G 190 33.541 49.905 190.889 1.00 10.45 C +ATOM 11290 CD1 LEU G 190 32.255 50.338 190.262 1.00 12.12 C +ATOM 11291 CD2 LEU G 190 34.255 48.926 189.995 1.00 8.50 C +ATOM 11292 N LYS G 191 33.485 50.549 194.304 1.00 30.18 N +ATOM 11293 CA LYS G 191 33.733 49.789 195.526 1.00 30.43 C +ATOM 11294 C LYS G 191 33.350 48.365 195.143 1.00 25.98 C +ATOM 11295 O LYS G 191 32.171 48.031 195.027 1.00 21.93 O +ATOM 11296 CB LYS G 191 32.860 50.323 196.667 1.00 42.63 C +ATOM 11297 CG LYS G 191 33.450 50.095 198.064 1.00 64.10 C +ATOM 11298 CD LYS G 191 32.826 51.048 199.091 1.00 83.04 C +ATOM 11299 CE LYS G 191 33.454 50.896 200.479 1.00 92.05 C +ATOM 11300 NZ LYS G 191 32.965 51.930 201.450 1.00 95.06 N +ATOM 11301 N TYR G 192 34.353 47.537 194.904 1.00 25.04 N +ATOM 11302 CA TYR G 192 34.091 46.182 194.456 1.00 29.03 C +ATOM 11303 C TYR G 192 34.877 45.134 195.235 1.00 32.89 C +ATOM 11304 O TYR G 192 35.707 45.460 196.086 1.00 37.51 O +ATOM 11305 CB TYR G 192 34.441 46.079 192.957 1.00 27.75 C +ATOM 11306 CG TYR G 192 35.911 46.351 192.671 1.00 21.38 C +ATOM 11307 CD1 TYR G 192 36.431 47.646 192.727 1.00 15.40 C +ATOM 11308 CD2 TYR G 192 36.794 45.302 192.401 1.00 21.63 C +ATOM 11309 CE1 TYR G 192 37.793 47.885 192.527 1.00 17.06 C +ATOM 11310 CE2 TYR G 192 38.157 45.535 192.195 1.00 19.20 C +ATOM 11311 CZ TYR G 192 38.647 46.828 192.262 1.00 17.72 C +ATOM 11312 OH TYR G 192 39.987 47.052 192.069 1.00 21.54 O +ATOM 11313 N GLU G 193 34.652 43.877 194.866 1.00 34.85 N +ATOM 11314 CA GLU G 193 35.313 42.746 195.479 1.00 36.12 C +ATOM 11315 C GLU G 193 35.467 41.701 194.377 1.00 36.05 C +ATOM 11316 O GLU G 193 34.490 41.300 193.740 1.00 38.47 O +ATOM 11317 CB GLU G 193 34.444 42.225 196.618 1.00 49.54 C +ATOM 11318 CG GLU G 193 35.145 41.303 197.600 1.00 73.17 C +ATOM 11319 CD GLU G 193 34.218 40.856 198.726 1.00 82.47 C +ATOM 11320 OE1 GLU G 193 33.489 39.855 198.537 1.00 87.03 O +ATOM 11321 OE2 GLU G 193 34.210 41.517 199.791 1.00 87.33 O +ATOM 11322 N VAL G 194 36.708 41.315 194.112 1.00 35.62 N +ATOM 11323 CA VAL G 194 37.015 40.339 193.074 1.00 34.49 C +ATOM 11324 C VAL G 194 37.006 38.930 193.649 1.00 35.94 C +ATOM 11325 O VAL G 194 37.333 38.736 194.822 1.00 40.94 O +ATOM 11326 CB VAL G 194 38.400 40.646 192.465 1.00 35.39 C +ATOM 11327 CG1 VAL G 194 38.823 39.552 191.495 1.00 41.35 C +ATOM 11328 CG2 VAL G 194 38.348 41.981 191.740 1.00 43.51 C +ATOM 11329 N GLN G 195 36.635 37.953 192.827 1.00 36.21 N +ATOM 11330 CA GLN G 195 36.601 36.567 193.266 1.00 35.43 C +ATOM 11331 C GLN G 195 36.943 35.656 192.097 1.00 28.48 C +ATOM 11332 O GLN G 195 36.276 35.687 191.053 1.00 29.57 O +ATOM 11333 CB GLN G 195 35.201 36.223 193.797 1.00 51.60 C +ATOM 11334 CG GLN G 195 35.185 35.160 194.885 1.00 64.83 C +ATOM 11335 CD GLN G 195 35.835 35.651 196.165 1.00 76.47 C +ATOM 11336 OE1 GLN G 195 36.856 35.116 196.601 1.00 85.00 O +ATOM 11337 NE2 GLN G 195 35.251 36.684 196.770 1.00 77.39 N +ATOM 11338 N GLY G 196 38.005 34.880 192.254 1.00 23.24 N +ATOM 11339 CA GLY G 196 38.374 33.951 191.205 1.00 27.67 C +ATOM 11340 C GLY G 196 39.422 34.447 190.238 1.00 30.95 C +ATOM 11341 O GLY G 196 40.248 35.303 190.577 1.00 34.38 O +ATOM 11342 N GLU G 197 39.363 33.915 189.019 1.00 29.03 N +ATOM 11343 CA GLU G 197 40.310 34.249 187.966 1.00 22.63 C +ATOM 11344 C GLU G 197 39.940 35.524 187.198 1.00 23.53 C +ATOM 11345 O GLU G 197 39.527 35.461 186.029 1.00 29.79 O +ATOM 11346 CB GLU G 197 40.407 33.070 186.999 1.00 24.46 C +ATOM 11347 CG GLU G 197 41.600 33.115 186.056 1.00 35.13 C +ATOM 11348 CD GLU G 197 42.843 32.443 186.622 1.00 37.84 C +ATOM 11349 OE1 GLU G 197 42.964 32.327 187.861 1.00 37.46 O +ATOM 11350 OE2 GLU G 197 43.706 32.027 185.816 1.00 39.80 O +ATOM 11351 N VAL G 198 40.043 36.671 187.862 1.00 15.47 N +ATOM 11352 CA VAL G 198 39.748 37.937 187.213 1.00 12.88 C +ATOM 11353 C VAL G 198 40.853 38.927 187.532 1.00 14.99 C +ATOM 11354 O VAL G 198 41.268 39.042 188.681 1.00 18.90 O +ATOM 11355 CB VAL G 198 38.327 38.482 187.573 1.00 15.67 C +ATOM 11356 CG1 VAL G 198 37.724 37.695 188.711 1.00 9.12 C +ATOM 11357 CG2 VAL G 198 38.356 39.996 187.866 1.00 11.82 C +ATOM 11358 N PHE G 199 41.362 39.591 186.490 1.00 15.91 N +ATOM 11359 CA PHE G 199 42.451 40.567 186.617 1.00 16.32 C +ATOM 11360 C PHE G 199 42.018 41.961 186.184 1.00 16.02 C +ATOM 11361 O PHE G 199 41.028 42.126 185.469 1.00 19.81 O +ATOM 11362 CB PHE G 199 43.651 40.153 185.765 1.00 8.50 C +ATOM 11363 CG PHE G 199 44.022 38.712 185.910 1.00 17.02 C +ATOM 11364 CD1 PHE G 199 43.383 37.733 185.152 1.00 15.61 C +ATOM 11365 CD2 PHE G 199 45.011 38.323 186.804 1.00 25.47 C +ATOM 11366 CE1 PHE G 199 43.725 36.390 185.282 1.00 17.82 C +ATOM 11367 CE2 PHE G 199 45.362 36.981 186.941 1.00 25.04 C +ATOM 11368 CZ PHE G 199 44.713 36.014 186.174 1.00 25.74 C +ATOM 11369 N THR G 200 42.795 42.957 186.592 1.00 14.77 N +ATOM 11370 CA THR G 200 42.529 44.349 186.244 1.00 11.49 C +ATOM 11371 C THR G 200 43.641 44.778 185.297 1.00 12.05 C +ATOM 11372 O THR G 200 44.812 44.801 185.682 1.00 21.22 O +ATOM 11373 CB THR G 200 42.539 45.254 187.498 1.00 15.92 C +ATOM 11374 OG1 THR G 200 41.560 44.790 188.449 1.00 30.97 O +ATOM 11375 CG2 THR G 200 42.225 46.671 187.132 1.00 17.70 C +ATOM 11376 N LYS G 201 43.279 45.047 184.044 1.00 12.17 N +ATOM 11377 CA LYS G 201 44.244 45.459 183.028 1.00 9.96 C +ATOM 11378 C LYS G 201 43.755 46.724 182.312 1.00 10.62 C +ATOM 11379 O LYS G 201 42.604 47.141 182.506 1.00 9.89 O +ATOM 11380 CB LYS G 201 44.477 44.326 182.017 1.00 13.51 C +ATOM 11381 CG LYS G 201 45.192 43.077 182.561 1.00 13.58 C +ATOM 11382 CD LYS G 201 46.489 43.429 183.281 1.00 19.70 C +ATOM 11383 CE LYS G 201 47.465 42.264 183.291 1.00 22.49 C +ATOM 11384 NZ LYS G 201 47.984 41.999 181.917 1.00 35.39 N +ATOM 11385 N PRO G 202 44.639 47.389 181.527 1.00 10.95 N +ATOM 11386 CA PRO G 202 44.279 48.613 180.794 1.00 10.34 C +ATOM 11387 C PRO G 202 43.222 48.287 179.747 1.00 15.40 C +ATOM 11388 O PRO G 202 43.343 47.278 179.053 1.00 18.91 O +ATOM 11389 CB PRO G 202 45.588 49.004 180.122 1.00 8.50 C +ATOM 11390 CG PRO G 202 46.622 48.429 181.014 1.00 8.50 C +ATOM 11391 CD PRO G 202 46.066 47.086 181.330 1.00 11.12 C +ATOM 11392 N GLN G 203 42.211 49.144 179.604 1.00 12.77 N +ATOM 11393 CA GLN G 203 41.132 48.889 178.646 1.00 9.47 C +ATOM 11394 C GLN G 203 41.590 48.924 177.213 1.00 10.33 C +ATOM 11395 O GLN G 203 42.430 49.752 176.847 1.00 9.36 O +ATOM 11396 CB GLN G 203 40.004 49.885 178.823 1.00 8.50 C +ATOM 11397 CG GLN G 203 40.409 51.309 178.668 1.00 8.50 C +ATOM 11398 CD GLN G 203 39.238 52.217 178.813 1.00 16.61 C +ATOM 11399 OE1 GLN G 203 39.037 53.096 177.996 1.00 27.52 O +ATOM 11400 NE2 GLN G 203 38.442 52.017 179.869 1.00 31.94 N +ATOM 11401 N LEU G 204 41.001 48.040 176.405 1.00 12.86 N +ATOM 11402 CA LEU G 204 41.345 47.933 174.979 1.00 13.02 C +ATOM 11403 C LEU G 204 40.576 48.901 174.109 1.00 11.74 C +ATOM 11404 O LEU G 204 41.029 49.258 173.024 1.00 14.31 O +ATOM 11405 CB LEU G 204 41.121 46.517 174.461 1.00 15.56 C +ATOM 11406 CG LEU G 204 41.819 45.478 175.324 1.00 17.59 C +ATOM 11407 CD1 LEU G 204 40.791 44.935 176.307 1.00 18.01 C +ATOM 11408 CD2 LEU G 204 42.405 44.384 174.460 1.00 18.58 C +ATOM 11409 N TRP G 205 39.367 49.241 174.542 1.00 13.94 N +ATOM 11410 CA TRP G 205 38.557 50.199 173.806 1.00 18.70 C +ATOM 11411 C TRP G 205 39.098 51.564 174.183 1.00 26.27 C +ATOM 11412 O TRP G 205 39.658 51.727 175.267 1.00 37.93 O +ATOM 11413 CB TRP G 205 37.071 50.093 174.173 1.00 10.16 C +ATOM 11414 CG TRP G 205 36.800 49.937 175.627 1.00 17.60 C +ATOM 11415 CD1 TRP G 205 36.653 50.935 176.561 1.00 16.22 C +ATOM 11416 CD2 TRP G 205 36.625 48.704 176.328 1.00 22.20 C +ATOM 11417 NE1 TRP G 205 36.397 50.392 177.795 1.00 11.07 N +ATOM 11418 CE2 TRP G 205 36.373 49.025 177.681 1.00 21.91 C +ATOM 11419 CE3 TRP G 205 36.658 47.355 175.945 1.00 16.65 C +ATOM 11420 CZ2 TRP G 205 36.154 48.037 178.654 1.00 25.91 C +ATOM 11421 CZ3 TRP G 205 36.442 46.382 176.909 1.00 19.70 C +ATOM 11422 CH2 TRP G 205 36.194 46.725 178.246 1.00 20.00 C +ATOM 11423 N PRO G 206 39.003 52.537 173.271 1.00 27.46 N +ATOM 11424 CA PRO G 206 39.487 53.893 173.522 1.00 30.14 C +ATOM 11425 C PRO G 206 38.519 54.740 174.362 1.00 35.75 C +ATOM 11426 O PRO G 206 39.014 55.637 175.084 1.00 41.02 O +ATOM 11427 CB PRO G 206 39.640 54.444 172.115 1.00 35.40 C +ATOM 11428 CG PRO G 206 38.482 53.813 171.404 1.00 35.16 C +ATOM 11429 CD PRO G 206 38.552 52.388 171.879 1.00 31.77 C +ATOM 11430 OXT PRO G 206 37.288 54.510 174.294 1.00 35.78 O +TER 11431 PRO G 206 +ATOM 11432 N GLN H 1 74.298 43.643 163.292 1.00 61.01 N +ATOM 11433 CA GLN H 1 74.122 45.082 163.598 1.00 51.59 C +ATOM 11434 C GLN H 1 73.890 45.804 162.275 1.00 52.49 C +ATOM 11435 O GLN H 1 74.709 46.582 161.787 1.00 59.86 O +ATOM 11436 CB GLN H 1 75.251 45.641 164.495 1.00 38.67 C +ATOM 11437 CG GLN H 1 76.473 46.265 163.836 1.00 48.72 C +ATOM 11438 CD GLN H 1 77.220 45.317 162.934 1.00 61.57 C +ATOM 11439 OE1 GLN H 1 77.057 44.098 163.030 1.00 73.71 O +ATOM 11440 NE2 GLN H 1 78.029 45.867 162.031 1.00 60.61 N +ATOM 11441 N THR H 2 72.751 45.492 161.671 1.00 44.40 N +ATOM 11442 CA THR H 2 72.393 46.087 160.398 1.00 36.59 C +ATOM 11443 C THR H 2 71.091 46.837 160.572 1.00 33.11 C +ATOM 11444 O THR H 2 70.205 46.372 161.285 1.00 38.26 O +ATOM 11445 CB THR H 2 72.216 44.993 159.319 1.00 34.41 C +ATOM 11446 OG1 THR H 2 73.351 44.114 159.342 1.00 44.50 O +ATOM 11447 CG2 THR H 2 72.111 45.610 157.936 1.00 44.43 C +ATOM 11448 N ASP H 3 71.003 48.024 159.983 1.00 28.21 N +ATOM 11449 CA ASP H 3 69.780 48.798 160.062 1.00 21.77 C +ATOM 11450 C ASP H 3 68.868 48.272 158.960 1.00 25.53 C +ATOM 11451 O ASP H 3 69.009 48.631 157.787 1.00 28.12 O +ATOM 11452 CB ASP H 3 70.068 50.281 159.861 1.00 28.26 C +ATOM 11453 CG ASP H 3 68.930 51.162 160.344 1.00 35.71 C +ATOM 11454 OD1 ASP H 3 67.825 50.625 160.585 1.00 36.24 O +ATOM 11455 OD2 ASP H 3 69.142 52.387 160.499 1.00 39.30 O +ATOM 11456 N MET H 4 67.957 47.385 159.340 1.00 22.82 N +ATOM 11457 CA MET H 4 67.039 46.775 158.390 1.00 19.13 C +ATOM 11458 C MET H 4 65.852 47.647 158.037 1.00 16.56 C +ATOM 11459 O MET H 4 64.893 47.170 157.432 1.00 17.68 O +ATOM 11460 CB MET H 4 66.568 45.417 158.917 1.00 12.06 C +ATOM 11461 CG MET H 4 67.646 44.364 158.874 1.00 9.91 C +ATOM 11462 SD MET H 4 68.317 44.150 157.214 1.00 8.50 S +ATOM 11463 CE MET H 4 67.003 43.100 156.504 1.00 16.54 C +ATOM 11464 N SER H 5 65.938 48.928 158.378 1.00 12.85 N +ATOM 11465 CA SER H 5 64.867 49.884 158.107 1.00 14.25 C +ATOM 11466 C SER H 5 64.460 49.951 156.645 1.00 15.59 C +ATOM 11467 O SER H 5 65.308 50.010 155.755 1.00 21.71 O +ATOM 11468 CB SER H 5 65.274 51.285 158.571 1.00 14.23 C +ATOM 11469 OG SER H 5 65.200 51.404 159.979 1.00 16.75 O +ATOM 11470 N ARG H 6 63.150 49.942 156.413 1.00 16.24 N +ATOM 11471 CA ARG H 6 62.594 50.040 155.065 1.00 16.53 C +ATOM 11472 C ARG H 6 62.878 48.791 154.211 1.00 16.16 C +ATOM 11473 O ARG H 6 62.620 48.787 153.009 1.00 20.56 O +ATOM 11474 CB ARG H 6 63.153 51.323 154.385 1.00 26.04 C +ATOM 11475 CG ARG H 6 62.138 52.390 153.860 1.00 16.27 C +ATOM 11476 CD ARG H 6 61.346 53.155 154.935 1.00 8.50 C +ATOM 11477 NE ARG H 6 59.897 53.168 154.657 1.00 18.07 N +ATOM 11478 CZ ARG H 6 59.318 53.722 153.583 1.00 25.75 C +ATOM 11479 NH1 ARG H 6 60.051 54.338 152.656 1.00 21.75 N +ATOM 11480 NH2 ARG H 6 58.001 53.627 153.410 1.00 9.15 N +ATOM 11481 N LYS H 7 63.362 47.725 154.846 1.00 16.37 N +ATOM 11482 CA LYS H 7 63.672 46.481 154.155 1.00 11.74 C +ATOM 11483 C LYS H 7 62.843 45.303 154.662 1.00 10.22 C +ATOM 11484 O LYS H 7 62.216 45.376 155.728 1.00 8.50 O +ATOM 11485 CB LYS H 7 65.171 46.195 154.259 1.00 8.50 C +ATOM 11486 CG LYS H 7 66.002 47.153 153.419 1.00 16.17 C +ATOM 11487 CD LYS H 7 67.439 47.173 153.870 1.00 31.82 C +ATOM 11488 CE LYS H 7 68.254 48.190 153.101 1.00 37.53 C +ATOM 11489 NZ LYS H 7 69.611 48.342 153.695 1.00 55.80 N +ATOM 11490 N ALA H 8 62.800 44.243 153.862 1.00 8.89 N +ATOM 11491 CA ALA H 8 62.057 43.042 154.197 1.00 8.50 C +ATOM 11492 C ALA H 8 62.796 41.854 153.619 1.00 8.50 C +ATOM 11493 O ALA H 8 63.503 41.991 152.627 1.00 8.61 O +ATOM 11494 CB ALA H 8 60.650 43.118 153.621 1.00 8.50 C +ATOM 11495 N PHE H 9 62.713 40.714 154.295 1.00 8.50 N +ATOM 11496 CA PHE H 9 63.337 39.498 153.800 1.00 8.50 C +ATOM 11497 C PHE H 9 62.258 38.905 152.907 1.00 10.21 C +ATOM 11498 O PHE H 9 61.076 38.906 153.280 1.00 8.50 O +ATOM 11499 CB PHE H 9 63.613 38.511 154.931 1.00 9.66 C +ATOM 11500 CG PHE H 9 64.705 38.926 155.877 1.00 8.50 C +ATOM 11501 CD1 PHE H 9 65.997 39.128 155.426 1.00 8.50 C +ATOM 11502 CD2 PHE H 9 64.447 39.061 157.236 1.00 8.50 C +ATOM 11503 CE1 PHE H 9 67.012 39.455 156.315 1.00 8.50 C +ATOM 11504 CE2 PHE H 9 65.453 39.387 158.127 1.00 8.50 C +ATOM 11505 CZ PHE H 9 66.736 39.583 157.666 1.00 8.50 C +ATOM 11506 N VAL H 10 62.643 38.413 151.735 1.00 10.95 N +ATOM 11507 CA VAL H 10 61.673 37.821 150.813 1.00 11.88 C +ATOM 11508 C VAL H 10 62.055 36.401 150.356 1.00 11.12 C +ATOM 11509 O VAL H 10 63.158 36.173 149.837 1.00 10.27 O +ATOM 11510 CB VAL H 10 61.363 38.793 149.612 1.00 15.52 C +ATOM 11511 CG1 VAL H 10 62.583 39.651 149.282 1.00 16.71 C +ATOM 11512 CG2 VAL H 10 60.893 38.033 148.382 1.00 8.50 C +ATOM 11513 N PHE H 11 61.162 35.448 150.652 1.00 9.47 N +ATOM 11514 CA PHE H 11 61.308 34.030 150.302 1.00 8.50 C +ATOM 11515 C PHE H 11 60.414 33.808 149.091 1.00 9.02 C +ATOM 11516 O PHE H 11 59.231 33.511 149.244 1.00 8.50 O +ATOM 11517 CB PHE H 11 60.808 33.171 151.466 1.00 10.69 C +ATOM 11518 CG PHE H 11 61.443 33.506 152.795 1.00 9.93 C +ATOM 11519 CD1 PHE H 11 62.645 32.929 153.179 1.00 15.44 C +ATOM 11520 CD2 PHE H 11 60.854 34.410 153.649 1.00 8.50 C +ATOM 11521 CE1 PHE H 11 63.242 33.258 154.386 1.00 8.50 C +ATOM 11522 CE2 PHE H 11 61.444 34.736 154.850 1.00 8.50 C +ATOM 11523 CZ PHE H 11 62.641 34.158 155.213 1.00 8.50 C +ATOM 11524 N PRO H 12 60.973 33.920 147.872 1.00 9.40 N +ATOM 11525 CA PRO H 12 60.270 33.767 146.592 1.00 10.57 C +ATOM 11526 C PRO H 12 59.637 32.432 146.274 1.00 20.15 C +ATOM 11527 O PRO H 12 58.642 32.381 145.550 1.00 27.68 O +ATOM 11528 CB PRO H 12 61.342 34.111 145.558 1.00 8.50 C +ATOM 11529 CG PRO H 12 62.328 34.913 146.315 1.00 15.06 C +ATOM 11530 CD PRO H 12 62.395 34.182 147.628 1.00 12.88 C +ATOM 11531 N LYS H 13 60.239 31.340 146.731 1.00 29.46 N +ATOM 11532 CA LYS H 13 59.669 30.030 146.443 1.00 32.32 C +ATOM 11533 C LYS H 13 59.670 29.046 147.591 1.00 34.70 C +ATOM 11534 O LYS H 13 60.452 29.176 148.547 1.00 33.14 O +ATOM 11535 CB LYS H 13 60.291 29.402 145.191 1.00 28.63 C +ATOM 11536 CG LYS H 13 61.796 29.474 145.064 1.00 37.03 C +ATOM 11537 CD LYS H 13 62.205 29.006 143.654 1.00 53.60 C +ATOM 11538 CE LYS H 13 63.697 29.209 143.360 1.00 65.06 C +ATOM 11539 NZ LYS H 13 64.596 28.391 144.237 1.00 68.42 N +ATOM 11540 N GLU H 14 58.765 28.070 147.489 1.00 36.99 N +ATOM 11541 CA GLU H 14 58.608 27.021 148.501 1.00 43.21 C +ATOM 11542 C GLU H 14 59.903 26.242 148.660 1.00 44.05 C +ATOM 11543 O GLU H 14 60.409 25.639 147.704 1.00 45.65 O +ATOM 11544 CB GLU H 14 57.462 26.060 148.142 1.00 40.40 C +ATOM 11545 CG GLU H 14 57.096 25.097 149.272 1.00 46.29 C +ATOM 11546 CD GLU H 14 55.867 24.243 148.971 1.00 54.58 C +ATOM 11547 OE1 GLU H 14 54.746 24.791 148.860 1.00 57.28 O +ATOM 11548 OE2 GLU H 14 56.016 23.009 148.869 1.00 55.93 O +ATOM 11549 N SER H 15 60.452 26.281 149.867 1.00 46.18 N +ATOM 11550 CA SER H 15 61.696 25.594 150.141 1.00 43.99 C +ATOM 11551 C SER H 15 61.674 24.739 151.395 1.00 43.87 C +ATOM 11552 O SER H 15 60.703 24.709 152.165 1.00 40.19 O +ATOM 11553 CB SER H 15 62.859 26.585 150.185 1.00 45.40 C +ATOM 11554 OG SER H 15 62.586 27.674 151.051 1.00 57.75 O +ATOM 11555 N ASP H 16 62.764 24.005 151.540 1.00 46.59 N +ATOM 11556 CA ASP H 16 62.997 23.084 152.634 1.00 46.16 C +ATOM 11557 C ASP H 16 64.259 23.618 153.308 1.00 41.52 C +ATOM 11558 O ASP H 16 64.535 23.327 154.466 1.00 37.81 O +ATOM 11559 CB ASP H 16 63.295 21.712 152.001 1.00 56.63 C +ATOM 11560 CG ASP H 16 62.992 20.541 152.913 1.00 67.47 C +ATOM 11561 OD1 ASP H 16 62.151 20.677 153.827 1.00 79.27 O +ATOM 11562 OD2 ASP H 16 63.580 19.459 152.683 1.00 65.75 O +ATOM 11563 N THR H 17 64.963 24.480 152.577 1.00 40.46 N +ATOM 11564 CA THR H 17 66.241 25.043 152.989 1.00 39.25 C +ATOM 11565 C THR H 17 66.364 26.531 153.326 1.00 39.57 C +ATOM 11566 O THR H 17 67.343 26.931 153.968 1.00 42.26 O +ATOM 11567 CB THR H 17 67.269 24.741 151.888 1.00 41.11 C +ATOM 11568 OG1 THR H 17 66.718 25.115 150.615 1.00 40.65 O +ATOM 11569 CG2 THR H 17 67.583 23.255 151.844 1.00 51.21 C +ATOM 11570 N SER H 18 65.428 27.354 152.860 1.00 34.67 N +ATOM 11571 CA SER H 18 65.497 28.794 153.107 1.00 23.11 C +ATOM 11572 C SER H 18 64.961 29.228 154.466 1.00 20.67 C +ATOM 11573 O SER H 18 63.891 28.775 154.897 1.00 15.78 O +ATOM 11574 CB SER H 18 64.772 29.558 151.999 1.00 21.03 C +ATOM 11575 OG SER H 18 65.289 29.212 150.726 1.00 21.39 O +ATOM 11576 N TYR H 19 65.728 30.096 155.132 1.00 14.50 N +ATOM 11577 CA TYR H 19 65.371 30.650 156.433 1.00 13.30 C +ATOM 11578 C TYR H 19 66.381 31.709 156.861 1.00 13.93 C +ATOM 11579 O TYR H 19 67.465 31.819 156.280 1.00 11.69 O +ATOM 11580 CB TYR H 19 65.281 29.556 157.503 1.00 19.19 C +ATOM 11581 CG TYR H 19 66.599 28.933 157.908 1.00 24.68 C +ATOM 11582 CD1 TYR H 19 67.377 29.492 158.922 1.00 30.71 C +ATOM 11583 CD2 TYR H 19 67.055 27.773 157.300 1.00 30.70 C +ATOM 11584 CE1 TYR H 19 68.577 28.909 159.319 1.00 31.71 C +ATOM 11585 CE2 TYR H 19 68.253 27.178 157.687 1.00 36.71 C +ATOM 11586 CZ TYR H 19 69.006 27.753 158.698 1.00 34.59 C +ATOM 11587 OH TYR H 19 70.182 27.169 159.102 1.00 43.95 O +ATOM 11588 N VAL H 20 66.005 32.503 157.860 1.00 15.76 N +ATOM 11589 CA VAL H 20 66.870 33.549 158.392 1.00 12.10 C +ATOM 11590 C VAL H 20 66.903 33.351 159.895 1.00 17.57 C +ATOM 11591 O VAL H 20 65.847 33.253 160.539 1.00 17.99 O +ATOM 11592 CB VAL H 20 66.320 34.948 158.112 1.00 12.84 C +ATOM 11593 CG1 VAL H 20 67.205 35.987 158.753 1.00 11.73 C +ATOM 11594 CG2 VAL H 20 66.259 35.185 156.635 1.00 20.28 C +ATOM 11595 N SER H 21 68.110 33.253 160.439 1.00 17.84 N +ATOM 11596 CA SER H 21 68.295 33.065 161.861 1.00 16.46 C +ATOM 11597 C SER H 21 68.546 34.405 162.519 1.00 14.55 C +ATOM 11598 O SER H 21 69.365 35.193 162.051 1.00 17.34 O +ATOM 11599 CB SER H 21 69.481 32.144 162.108 1.00 30.80 C +ATOM 11600 OG SER H 21 69.659 31.909 163.497 1.00 52.04 O +ATOM 11601 N LEU H 22 67.815 34.672 163.589 1.00 12.07 N +ATOM 11602 CA LEU H 22 67.948 35.915 164.328 1.00 13.82 C +ATOM 11603 C LEU H 22 68.694 35.620 165.633 1.00 22.24 C +ATOM 11604 O LEU H 22 68.364 34.660 166.354 1.00 25.51 O +ATOM 11605 CB LEU H 22 66.566 36.502 164.618 1.00 9.22 C +ATOM 11606 CG LEU H 22 66.021 37.582 163.692 1.00 8.50 C +ATOM 11607 CD1 LEU H 22 66.334 37.303 162.238 1.00 8.50 C +ATOM 11608 CD2 LEU H 22 64.533 37.692 163.919 1.00 8.50 C +ATOM 11609 N LYS H 23 69.720 36.423 165.910 1.00 27.80 N +ATOM 11610 CA LYS H 23 70.533 36.276 167.114 1.00 32.44 C +ATOM 11611 C LYS H 23 70.163 37.298 168.173 1.00 34.76 C +ATOM 11612 O LYS H 23 70.341 38.500 167.986 1.00 34.43 O +ATOM 11613 CB LYS H 23 72.026 36.368 166.779 1.00 36.40 C +ATOM 11614 CG LYS H 23 72.582 35.053 166.250 1.00 49.90 C +ATOM 11615 CD LYS H 23 73.855 35.207 165.439 1.00 38.36 C +ATOM 11616 CE LYS H 23 74.028 33.970 164.552 1.00 56.64 C +ATOM 11617 NZ LYS H 23 72.819 33.662 163.681 1.00 49.28 N +ATOM 11618 N ALA H 24 69.632 36.805 169.283 1.00 43.45 N +ATOM 11619 CA ALA H 24 69.229 37.655 170.384 1.00 53.85 C +ATOM 11620 C ALA H 24 70.196 37.441 171.537 1.00 66.11 C +ATOM 11621 O ALA H 24 70.516 36.301 171.885 1.00 72.24 O +ATOM 11622 CB ALA H 24 67.824 37.311 170.817 1.00 51.03 C +ATOM 11623 N PRO H 25 70.726 38.535 172.107 1.00 73.91 N +ATOM 11624 CA PRO H 25 71.667 38.451 173.231 1.00 78.30 C +ATOM 11625 C PRO H 25 70.910 38.352 174.558 1.00 80.40 C +ATOM 11626 O PRO H 25 70.957 39.259 175.397 1.00 79.31 O +ATOM 11627 CB PRO H 25 72.442 39.754 173.107 1.00 80.43 C +ATOM 11628 CG PRO H 25 71.392 40.704 172.619 1.00 77.50 C +ATOM 11629 CD PRO H 25 70.643 39.912 171.584 1.00 73.64 C +ATOM 11630 N LEU H 26 70.217 37.233 174.735 1.00 81.47 N +ATOM 11631 CA LEU H 26 69.424 37.002 175.926 1.00 82.63 C +ATOM 11632 C LEU H 26 70.237 36.343 177.042 1.00 85.64 C +ATOM 11633 O LEU H 26 71.038 35.434 176.798 1.00 83.63 O +ATOM 11634 CB LEU H 26 68.189 36.174 175.560 1.00 76.08 C +ATOM 11635 CG LEU H 26 66.835 36.643 176.097 1.00 70.51 C +ATOM 11636 CD1 LEU H 26 66.729 38.162 176.097 1.00 70.23 C +ATOM 11637 CD2 LEU H 26 65.751 36.019 175.253 1.00 65.87 C +ATOM 11638 N THR H 27 70.041 36.846 178.261 1.00 88.69 N +ATOM 11639 CA THR H 27 70.726 36.349 179.451 1.00 87.28 C +ATOM 11640 C THR H 27 69.722 35.823 180.477 1.00 81.60 C +ATOM 11641 O THR H 27 69.907 34.747 181.043 1.00 82.45 O +ATOM 11642 CB THR H 27 71.569 37.467 180.106 1.00 93.06 C +ATOM 11643 OG1 THR H 27 70.768 38.653 180.257 1.00 97.96 O +ATOM 11644 CG2 THR H 27 72.796 37.786 179.256 1.00 95.51 C +ATOM 11645 N LYS H 28 68.684 36.613 180.738 1.00 75.19 N +ATOM 11646 CA LYS H 28 67.635 36.249 181.684 1.00 70.24 C +ATOM 11647 C LYS H 28 66.504 35.554 180.948 1.00 59.35 C +ATOM 11648 O LYS H 28 66.226 35.879 179.796 1.00 64.84 O +ATOM 11649 CB LYS H 28 67.069 37.506 182.364 1.00 80.03 C +ATOM 11650 CG LYS H 28 67.924 38.091 183.491 1.00 90.35 C +ATOM 11651 CD LYS H 28 67.794 37.282 184.778 1.00 96.73 C +ATOM 11652 CE LYS H 28 68.592 37.903 185.917 1.00100.41 C +ATOM 11653 NZ LYS H 28 68.399 37.156 187.193 1.00101.24 N +ATOM 11654 N PRO H 29 65.892 34.539 181.570 1.00 46.30 N +ATOM 11655 CA PRO H 29 64.783 33.825 180.941 1.00 44.57 C +ATOM 11656 C PRO H 29 63.526 34.719 180.947 1.00 39.12 C +ATOM 11657 O PRO H 29 63.326 35.506 181.879 1.00 35.54 O +ATOM 11658 CB PRO H 29 64.636 32.589 181.832 1.00 46.49 C +ATOM 11659 CG PRO H 29 65.082 33.071 183.150 1.00 45.08 C +ATOM 11660 CD PRO H 29 66.308 33.858 182.800 1.00 43.29 C +ATOM 11661 N LEU H 30 62.693 34.596 179.911 1.00 29.22 N +ATOM 11662 CA LEU H 30 61.508 35.424 179.783 1.00 20.14 C +ATOM 11663 C LEU H 30 60.321 35.071 180.666 1.00 18.51 C +ATOM 11664 O LEU H 30 59.876 33.933 180.698 1.00 14.43 O +ATOM 11665 CB LEU H 30 61.048 35.484 178.323 1.00 16.18 C +ATOM 11666 CG LEU H 30 61.867 36.169 177.224 1.00 12.46 C +ATOM 11667 CD1 LEU H 30 62.899 37.120 177.815 1.00 16.62 C +ATOM 11668 CD2 LEU H 30 62.527 35.121 176.368 1.00 16.23 C +ATOM 11669 N LYS H 31 59.781 36.093 181.329 1.00 19.71 N +ATOM 11670 CA LYS H 31 58.606 35.983 182.203 1.00 17.90 C +ATOM 11671 C LYS H 31 57.405 36.689 181.561 1.00 18.93 C +ATOM 11672 O LYS H 31 56.300 36.714 182.121 1.00 13.58 O +ATOM 11673 CB LYS H 31 58.906 36.631 183.557 1.00 30.25 C +ATOM 11674 CG LYS H 31 59.728 35.758 184.503 1.00 53.80 C +ATOM 11675 CD LYS H 31 58.923 34.529 184.954 1.00 67.43 C +ATOM 11676 CE LYS H 31 59.743 33.576 185.819 1.00 68.13 C +ATOM 11677 NZ LYS H 31 58.929 32.394 186.229 1.00 77.01 N +ATOM 11678 N ALA H 32 57.665 37.300 180.403 1.00 22.24 N +ATOM 11679 CA ALA H 32 56.690 38.030 179.590 1.00 11.65 C +ATOM 11680 C ALA H 32 57.418 38.441 178.307 1.00 8.61 C +ATOM 11681 O ALA H 32 58.638 38.353 178.224 1.00 10.99 O +ATOM 11682 CB ALA H 32 56.197 39.255 180.334 1.00 8.50 C +ATOM 11683 N PHE H 33 56.676 38.850 177.292 1.00 11.50 N +ATOM 11684 CA PHE H 33 57.296 39.293 176.040 1.00 12.57 C +ATOM 11685 C PHE H 33 56.239 39.855 175.089 1.00 13.82 C +ATOM 11686 O PHE H 33 55.033 39.632 175.291 1.00 16.52 O +ATOM 11687 CB PHE H 33 58.054 38.137 175.368 1.00 9.18 C +ATOM 11688 CG PHE H 33 57.161 36.979 174.933 1.00 15.85 C +ATOM 11689 CD1 PHE H 33 56.574 36.960 173.667 1.00 12.84 C +ATOM 11690 CD2 PHE H 33 56.939 35.902 175.772 1.00 17.42 C +ATOM 11691 CE1 PHE H 33 55.793 35.903 173.247 1.00 8.50 C +ATOM 11692 CE2 PHE H 33 56.154 34.833 175.349 1.00 24.18 C +ATOM 11693 CZ PHE H 33 55.582 34.840 174.080 1.00 19.44 C +ATOM 11694 N THR H 34 56.693 40.616 174.098 1.00 8.50 N +ATOM 11695 CA THR H 34 55.817 41.180 173.075 1.00 9.97 C +ATOM 11696 C THR H 34 56.622 41.064 171.811 1.00 10.92 C +ATOM 11697 O THR H 34 57.806 41.428 171.805 1.00 16.22 O +ATOM 11698 CB THR H 34 55.539 42.683 173.277 1.00 18.61 C +ATOM 11699 OG1 THR H 34 54.977 42.913 174.575 1.00 22.12 O +ATOM 11700 CG2 THR H 34 54.564 43.191 172.214 1.00 12.49 C +ATOM 11701 N VAL H 35 56.034 40.489 170.773 1.00 8.50 N +ATOM 11702 CA VAL H 35 56.735 40.367 169.503 1.00 11.45 C +ATOM 11703 C VAL H 35 55.800 40.871 168.419 1.00 11.97 C +ATOM 11704 O VAL H 35 54.633 40.473 168.374 1.00 16.30 O +ATOM 11705 CB VAL H 35 57.255 38.929 169.230 1.00 8.50 C +ATOM 11706 CG1 VAL H 35 56.532 37.929 170.063 1.00 8.50 C +ATOM 11707 CG2 VAL H 35 57.110 38.589 167.775 1.00 8.50 C +ATOM 11708 N CYS H 36 56.279 41.835 167.635 1.00 8.94 N +ATOM 11709 CA CYS H 36 55.494 42.428 166.559 1.00 9.28 C +ATOM 11710 C CYS H 36 56.237 42.175 165.257 1.00 10.14 C +ATOM 11711 O CYS H 36 57.462 42.046 165.257 1.00 13.60 O +ATOM 11712 CB CYS H 36 55.348 43.937 166.763 1.00 8.50 C +ATOM 11713 SG CYS H 36 54.510 44.476 168.266 1.00 8.50 S +ATOM 11714 N LEU H 37 55.502 42.067 164.157 1.00 8.50 N +ATOM 11715 CA LEU H 37 56.105 41.846 162.853 1.00 8.57 C +ATOM 11716 C LEU H 37 55.116 42.126 161.729 1.00 10.04 C +ATOM 11717 O LEU H 37 53.908 42.255 161.963 1.00 8.50 O +ATOM 11718 CB LEU H 37 56.681 40.430 162.741 1.00 11.56 C +ATOM 11719 CG LEU H 37 55.760 39.223 162.884 1.00 8.50 C +ATOM 11720 CD1 LEU H 37 55.178 38.841 161.556 1.00 8.50 C +ATOM 11721 CD2 LEU H 37 56.565 38.082 163.425 1.00 11.22 C +ATOM 11722 N HIS H 38 55.641 42.240 160.511 1.00 10.11 N +ATOM 11723 CA HIS H 38 54.840 42.535 159.322 1.00 11.40 C +ATOM 11724 C HIS H 38 55.112 41.402 158.376 1.00 10.00 C +ATOM 11725 O HIS H 38 56.265 41.062 158.172 1.00 17.28 O +ATOM 11726 CB HIS H 38 55.371 43.808 158.651 1.00 16.36 C +ATOM 11727 CG HIS H 38 54.385 44.933 158.559 1.00 11.92 C +ATOM 11728 ND1 HIS H 38 54.597 46.163 159.151 1.00 20.67 N +ATOM 11729 CD2 HIS H 38 53.220 45.042 157.886 1.00 13.39 C +ATOM 11730 CE1 HIS H 38 53.605 46.981 158.847 1.00 19.27 C +ATOM 11731 NE2 HIS H 38 52.757 46.325 158.078 1.00 19.17 N +ATOM 11732 N PHE H 39 54.079 40.805 157.804 1.00 8.50 N +ATOM 11733 CA PHE H 39 54.302 39.724 156.854 1.00 8.50 C +ATOM 11734 C PHE H 39 53.304 39.871 155.731 1.00 8.55 C +ATOM 11735 O PHE H 39 52.292 40.548 155.882 1.00 11.66 O +ATOM 11736 CB PHE H 39 54.226 38.340 157.516 1.00 8.50 C +ATOM 11737 CG PHE H 39 52.832 37.903 157.901 1.00 8.50 C +ATOM 11738 CD1 PHE H 39 52.278 38.278 159.110 1.00 8.50 C +ATOM 11739 CD2 PHE H 39 52.093 37.097 157.061 1.00 8.50 C +ATOM 11740 CE1 PHE H 39 51.017 37.854 159.465 1.00 8.50 C +ATOM 11741 CE2 PHE H 39 50.844 36.671 157.408 1.00 8.50 C +ATOM 11742 CZ PHE H 39 50.302 37.047 158.608 1.00 8.50 C +ATOM 11743 N TYR H 40 53.604 39.276 154.591 1.00 8.50 N +ATOM 11744 CA TYR H 40 52.728 39.383 153.439 1.00 9.16 C +ATOM 11745 C TYR H 40 52.879 38.125 152.583 1.00 10.74 C +ATOM 11746 O TYR H 40 53.894 37.942 151.912 1.00 8.73 O +ATOM 11747 CB TYR H 40 53.117 40.636 152.640 1.00 8.50 C +ATOM 11748 CG TYR H 40 52.273 40.892 151.423 1.00 8.50 C +ATOM 11749 CD1 TYR H 40 50.975 40.401 151.347 1.00 10.08 C +ATOM 11750 CD2 TYR H 40 52.766 41.618 150.346 1.00 8.50 C +ATOM 11751 CE1 TYR H 40 50.184 40.621 150.235 1.00 9.13 C +ATOM 11752 CE2 TYR H 40 51.988 41.844 149.226 1.00 8.50 C +ATOM 11753 CZ TYR H 40 50.690 41.340 149.179 1.00 10.61 C +ATOM 11754 OH TYR H 40 49.870 41.559 148.099 1.00 14.40 O +ATOM 11755 N THR H 41 51.864 37.267 152.597 1.00 12.14 N +ATOM 11756 CA THR H 41 51.909 36.025 151.830 1.00 13.13 C +ATOM 11757 C THR H 41 50.577 35.689 151.173 1.00 16.74 C +ATOM 11758 O THR H 41 49.531 36.227 151.545 1.00 16.33 O +ATOM 11759 CB THR H 41 52.328 34.836 152.713 1.00 18.38 C +ATOM 11760 OG1 THR H 41 52.446 33.659 151.899 1.00 23.80 O +ATOM 11761 CG2 THR H 41 51.285 34.591 153.811 1.00 11.84 C +ATOM 11762 N GLU H 42 50.614 34.735 150.249 1.00 19.76 N +ATOM 11763 CA GLU H 42 49.415 34.331 149.526 1.00 26.27 C +ATOM 11764 C GLU H 42 48.999 32.898 149.874 1.00 27.27 C +ATOM 11765 O GLU H 42 48.123 32.330 149.238 1.00 33.98 O +ATOM 11766 CB GLU H 42 49.709 34.441 148.031 1.00 35.53 C +ATOM 11767 CG GLU H 42 48.559 34.974 147.178 1.00 49.57 C +ATOM 11768 CD GLU H 42 49.010 35.417 145.779 1.00 54.66 C +ATOM 11769 OE1 GLU H 42 49.063 34.565 144.845 1.00 55.59 O +ATOM 11770 OE2 GLU H 42 49.307 36.627 145.625 1.00 49.49 O +ATOM 11771 N LEU H 43 49.741 32.270 150.789 1.00 21.41 N +ATOM 11772 CA LEU H 43 49.491 30.887 151.213 1.00 12.63 C +ATOM 11773 C LEU H 43 48.206 30.672 152.002 1.00 17.79 C +ATOM 11774 O LEU H 43 47.619 29.604 151.926 1.00 15.86 O +ATOM 11775 CB LEU H 43 50.641 30.383 152.067 1.00 8.50 C +ATOM 11776 CG LEU H 43 51.878 29.725 151.484 1.00 15.09 C +ATOM 11777 CD1 LEU H 43 52.174 30.248 150.095 1.00 33.28 C +ATOM 11778 CD2 LEU H 43 53.048 29.975 152.432 1.00 14.19 C +ATOM 11779 N SER H 44 47.814 31.670 152.795 1.00 24.98 N +ATOM 11780 CA SER H 44 46.627 31.644 153.647 1.00 21.63 C +ATOM 11781 C SER H 44 45.436 30.815 153.160 1.00 28.52 C +ATOM 11782 O SER H 44 44.762 30.146 153.956 1.00 30.69 O +ATOM 11783 CB SER H 44 46.173 33.077 153.903 1.00 22.66 C +ATOM 11784 OG SER H 44 47.264 33.894 154.320 1.00 28.83 O +ATOM 11785 N SER H 45 45.204 30.834 151.855 1.00 35.17 N +ATOM 11786 CA SER H 45 44.088 30.121 151.233 1.00 42.67 C +ATOM 11787 C SER H 45 44.307 28.641 150.870 1.00 38.84 C +ATOM 11788 O SER H 45 43.350 27.940 150.531 1.00 38.94 O +ATOM 11789 CB SER H 45 43.661 30.882 149.977 1.00 54.46 C +ATOM 11790 OG SER H 45 43.540 32.275 150.233 1.00 67.72 O +ATOM 11791 N THR H 46 45.553 28.178 150.908 1.00 35.10 N +ATOM 11792 CA THR H 46 45.860 26.792 150.557 1.00 30.07 C +ATOM 11793 C THR H 46 46.525 25.925 151.657 1.00 31.46 C +ATOM 11794 O THR H 46 46.092 24.788 151.880 1.00 38.23 O +ATOM 11795 CB THR H 46 46.680 26.714 149.227 1.00 24.84 C +ATOM 11796 OG1 THR H 46 48.071 26.933 149.479 1.00 34.03 O +ATOM 11797 CG2 THR H 46 46.207 27.772 148.247 1.00 28.49 C +ATOM 11798 N ARG H 47 47.565 26.433 152.328 1.00 25.60 N +ATOM 11799 CA ARG H 47 48.235 25.658 153.380 1.00 20.80 C +ATOM 11800 C ARG H 47 48.571 26.486 154.606 1.00 19.15 C +ATOM 11801 O ARG H 47 48.273 27.676 154.658 1.00 22.52 O +ATOM 11802 CB ARG H 47 49.507 24.970 152.859 1.00 8.50 C +ATOM 11803 CG ARG H 47 50.669 25.879 152.535 1.00 8.50 C +ATOM 11804 CD ARG H 47 51.843 25.047 152.066 1.00 16.93 C +ATOM 11805 NE ARG H 47 53.014 25.825 151.648 1.00 23.70 N +ATOM 11806 CZ ARG H 47 53.961 26.266 152.474 1.00 18.93 C +ATOM 11807 NH1 ARG H 47 53.874 26.016 153.772 1.00 19.67 N +ATOM 11808 NH2 ARG H 47 55.021 26.904 151.996 1.00 11.87 N +ATOM 11809 N GLY H 48 49.122 25.826 155.620 1.00 19.05 N +ATOM 11810 CA GLY H 48 49.509 26.514 156.841 1.00 15.68 C +ATOM 11811 C GLY H 48 50.961 26.916 156.692 1.00 16.55 C +ATOM 11812 O GLY H 48 51.629 26.400 155.798 1.00 26.84 O +ATOM 11813 N TYR H 49 51.454 27.818 157.536 1.00 11.26 N +ATOM 11814 CA TYR H 49 52.852 28.257 157.453 1.00 14.40 C +ATOM 11815 C TYR H 49 53.350 28.863 158.759 1.00 19.77 C +ATOM 11816 O TYR H 49 52.552 29.366 159.561 1.00 23.61 O +ATOM 11817 CB TYR H 49 53.037 29.265 156.321 1.00 10.23 C +ATOM 11818 CG TYR H 49 52.042 30.398 156.351 1.00 15.21 C +ATOM 11819 CD1 TYR H 49 52.207 31.484 157.206 1.00 12.20 C +ATOM 11820 CD2 TYR H 49 50.927 30.379 155.521 1.00 15.80 C +ATOM 11821 CE1 TYR H 49 51.277 32.519 157.228 1.00 17.46 C +ATOM 11822 CE2 TYR H 49 49.998 31.403 155.532 1.00 12.24 C +ATOM 11823 CZ TYR H 49 50.171 32.471 156.382 1.00 16.56 C +ATOM 11824 OH TYR H 49 49.247 33.498 156.366 1.00 20.11 O +ATOM 11825 N SER H 50 54.665 28.829 158.965 1.00 16.34 N +ATOM 11826 CA SER H 50 55.249 29.372 160.177 1.00 20.47 C +ATOM 11827 C SER H 50 55.657 30.827 159.993 1.00 24.96 C +ATOM 11828 O SER H 50 56.380 31.175 159.045 1.00 30.11 O +ATOM 11829 CB SER H 50 56.467 28.550 160.594 1.00 25.07 C +ATOM 11830 OG SER H 50 57.144 29.128 161.703 1.00 31.04 O +ATOM 11831 N ILE H 51 55.205 31.667 160.920 1.00 22.93 N +ATOM 11832 CA ILE H 51 55.523 33.087 160.897 1.00 16.26 C +ATOM 11833 C ILE H 51 56.750 33.403 161.763 1.00 16.98 C +ATOM 11834 O ILE H 51 57.738 33.955 161.272 1.00 16.47 O +ATOM 11835 CB ILE H 51 54.315 33.916 161.358 1.00 11.27 C +ATOM 11836 CG1 ILE H 51 53.132 33.671 160.417 1.00 17.04 C +ATOM 11837 CG2 ILE H 51 54.660 35.383 161.370 1.00 8.50 C +ATOM 11838 CD1 ILE H 51 51.864 34.323 160.861 1.00 8.60 C +ATOM 11839 N PHE H 52 56.707 32.977 163.026 1.00 14.27 N +ATOM 11840 CA PHE H 52 57.792 33.219 163.976 1.00 12.15 C +ATOM 11841 C PHE H 52 58.029 31.947 164.790 1.00 16.35 C +ATOM 11842 O PHE H 52 57.090 31.455 165.420 1.00 17.53 O +ATOM 11843 CB PHE H 52 57.381 34.372 164.909 1.00 8.50 C +ATOM 11844 CG PHE H 52 58.483 34.871 165.800 1.00 8.50 C +ATOM 11845 CD1 PHE H 52 59.543 35.616 165.291 1.00 9.56 C +ATOM 11846 CD2 PHE H 52 58.443 34.625 167.156 1.00 8.50 C +ATOM 11847 CE1 PHE H 52 60.536 36.101 166.131 1.00 8.50 C +ATOM 11848 CE2 PHE H 52 59.434 35.111 167.994 1.00 8.50 C +ATOM 11849 CZ PHE H 52 60.478 35.848 167.479 1.00 8.50 C +ATOM 11850 N SER H 53 59.263 31.430 164.786 1.00 18.91 N +ATOM 11851 CA SER H 53 59.607 30.205 165.526 1.00 16.28 C +ATOM 11852 C SER H 53 60.761 30.404 166.521 1.00 13.09 C +ATOM 11853 O SER H 53 61.918 30.530 166.120 1.00 14.77 O +ATOM 11854 CB SER H 53 59.963 29.075 164.543 1.00 15.84 C +ATOM 11855 OG SER H 53 60.039 27.817 165.197 1.00 23.81 O +ATOM 11856 N TYR H 54 60.437 30.415 167.811 1.00 11.60 N +ATOM 11857 CA TYR H 54 61.420 30.586 168.887 1.00 14.59 C +ATOM 11858 C TYR H 54 61.571 29.222 169.551 1.00 24.38 C +ATOM 11859 O TYR H 54 60.654 28.761 170.241 1.00 30.10 O +ATOM 11860 CB TYR H 54 60.868 31.589 169.899 1.00 13.23 C +ATOM 11861 CG TYR H 54 61.797 31.991 171.011 1.00 19.00 C +ATOM 11862 CD1 TYR H 54 61.867 31.248 172.194 1.00 14.65 C +ATOM 11863 CD2 TYR H 54 62.543 33.174 170.928 1.00 24.88 C +ATOM 11864 CE1 TYR H 54 62.645 31.673 173.274 1.00 14.43 C +ATOM 11865 CE2 TYR H 54 63.329 33.615 172.002 1.00 24.29 C +ATOM 11866 CZ TYR H 54 63.370 32.861 173.165 1.00 22.46 C +ATOM 11867 OH TYR H 54 64.119 33.307 174.216 1.00 24.31 O +ATOM 11868 N ALA H 55 62.721 28.585 169.371 1.00 29.39 N +ATOM 11869 CA ALA H 55 62.945 27.253 169.930 1.00 33.30 C +ATOM 11870 C ALA H 55 64.088 27.141 170.929 1.00 35.88 C +ATOM 11871 O ALA H 55 65.089 27.853 170.822 1.00 36.48 O +ATOM 11872 CB ALA H 55 63.161 26.257 168.800 1.00 35.68 C +ATOM 11873 N THR H 56 63.945 26.194 171.857 1.00 40.35 N +ATOM 11874 CA THR H 56 64.936 25.902 172.897 1.00 41.78 C +ATOM 11875 C THR H 56 65.382 24.462 172.699 1.00 43.50 C +ATOM 11876 O THR H 56 64.723 23.688 171.999 1.00 41.82 O +ATOM 11877 CB THR H 56 64.329 25.963 174.321 1.00 38.84 C +ATOM 11878 OG1 THR H 56 63.428 27.072 174.432 1.00 45.72 O +ATOM 11879 CG2 THR H 56 65.443 26.119 175.354 1.00 49.28 C +ATOM 11880 N LYS H 57 66.482 24.096 173.346 1.00 48.25 N +ATOM 11881 CA LYS H 57 66.980 22.740 173.235 1.00 48.08 C +ATOM 11882 C LYS H 57 65.973 21.782 173.865 1.00 49.18 C +ATOM 11883 O LYS H 57 65.671 20.735 173.304 1.00 55.54 O +ATOM 11884 CB LYS H 57 68.381 22.614 173.807 1.00 24.33 C +ATOM 11885 CG LYS H 57 69.224 21.701 172.977 1.00 8.50 C +ATOM 11886 CD LYS H 57 70.698 21.983 173.147 1.00 15.17 C +ATOM 11887 CE LYS H 57 71.258 22.897 172.052 1.00 34.86 C +ATOM 11888 NZ LYS H 57 71.372 22.280 170.679 1.00 34.97 N +ATOM 11889 N ARG H 58 65.379 22.210 174.973 1.00 46.65 N +ATOM 11890 CA ARG H 58 64.381 21.427 175.697 1.00 45.18 C +ATOM 11891 C ARG H 58 62.991 21.440 175.050 1.00 42.16 C +ATOM 11892 O ARG H 58 62.284 20.439 175.066 1.00 41.01 O +ATOM 11893 CB ARG H 58 64.322 21.924 177.153 1.00 32.95 C +ATOM 11894 CG ARG H 58 63.017 21.681 177.917 1.00 20.57 C +ATOM 11895 CD ARG H 58 62.393 23.017 178.325 1.00 44.05 C +ATOM 11896 NE ARG H 58 63.425 24.019 178.614 1.00 53.35 N +ATOM 11897 CZ ARG H 58 63.653 25.122 177.896 1.00 50.45 C +ATOM 11898 NH1 ARG H 58 62.917 25.403 176.827 1.00 42.96 N +ATOM 11899 NH2 ARG H 58 64.668 25.920 178.213 1.00 47.35 N +ATOM 11900 N GLN H 59 62.602 22.581 174.489 1.00 41.37 N +ATOM 11901 CA GLN H 59 61.286 22.736 173.868 1.00 32.97 C +ATOM 11902 C GLN H 59 61.442 23.390 172.506 1.00 31.72 C +ATOM 11903 O GLN H 59 61.823 24.548 172.425 1.00 36.27 O +ATOM 11904 CB GLN H 59 60.395 23.596 174.779 1.00 23.86 C +ATOM 11905 CG GLN H 59 59.078 24.029 174.215 1.00 17.73 C +ATOM 11906 CD GLN H 59 58.207 22.876 173.792 1.00 24.92 C +ATOM 11907 OE1 GLN H 59 58.349 22.353 172.692 1.00 32.72 O +ATOM 11908 NE2 GLN H 59 57.282 22.485 174.651 1.00 30.32 N +ATOM 11909 N ASP H 60 61.138 22.648 171.442 1.00 32.27 N +ATOM 11910 CA ASP H 60 61.262 23.150 170.071 1.00 28.71 C +ATOM 11911 C ASP H 60 60.265 24.249 169.729 1.00 23.65 C +ATOM 11912 O ASP H 60 60.523 25.078 168.873 1.00 26.37 O +ATOM 11913 CB ASP H 60 61.165 21.995 169.056 1.00 37.20 C +ATOM 11914 CG ASP H 60 59.826 21.254 169.103 1.00 39.09 C +ATOM 11915 OD1 ASP H 60 59.414 20.801 170.189 1.00 45.80 O +ATOM 11916 OD2 ASP H 60 59.195 21.100 168.036 1.00 41.95 O +ATOM 11917 N ASN H 61 59.122 24.256 170.397 1.00 17.48 N +ATOM 11918 CA ASN H 61 58.112 25.269 170.143 1.00 10.45 C +ATOM 11919 C ASN H 61 57.885 26.097 171.390 1.00 12.85 C +ATOM 11920 O ASN H 61 56.790 26.073 171.966 1.00 15.09 O +ATOM 11921 CB ASN H 61 56.805 24.610 169.706 1.00 16.09 C +ATOM 11922 CG ASN H 61 56.918 23.930 168.343 1.00 37.64 C +ATOM 11923 OD1 ASN H 61 56.157 22.999 168.042 1.00 42.64 O +ATOM 11924 ND2 ASN H 61 57.870 24.392 167.507 1.00 40.28 N +ATOM 11925 N GLU H 62 58.930 26.810 171.821 1.00 11.70 N +ATOM 11926 CA GLU H 62 58.872 27.638 173.028 1.00 8.76 C +ATOM 11927 C GLU H 62 57.866 28.772 172.856 1.00 12.66 C +ATOM 11928 O GLU H 62 57.099 29.070 173.765 1.00 16.80 O +ATOM 11929 CB GLU H 62 60.259 28.167 173.383 1.00 8.50 C +ATOM 11930 CG GLU H 62 60.379 28.746 174.789 1.00 11.23 C +ATOM 11931 CD GLU H 62 60.226 27.701 175.869 1.00 18.37 C +ATOM 11932 OE1 GLU H 62 59.191 27.003 175.891 1.00 26.33 O +ATOM 11933 OE2 GLU H 62 61.141 27.569 176.701 1.00 27.06 O +ATOM 11934 N ILE H 63 57.929 29.443 171.712 1.00 15.66 N +ATOM 11935 CA ILE H 63 56.986 30.499 171.356 1.00 13.67 C +ATOM 11936 C ILE H 63 56.936 30.417 169.825 1.00 10.78 C +ATOM 11937 O ILE H 63 57.973 30.427 169.161 1.00 8.50 O +ATOM 11938 CB ILE H 63 57.360 31.934 171.933 1.00 18.56 C +ATOM 11939 CG1 ILE H 63 57.189 33.016 170.878 1.00 19.36 C +ATOM 11940 CG2 ILE H 63 58.732 31.979 172.572 1.00 12.76 C +ATOM 11941 CD1 ILE H 63 55.740 33.335 170.594 1.00 20.90 C +ATOM 11942 N LEU H 64 55.735 30.205 169.292 1.00 11.09 N +ATOM 11943 CA LEU H 64 55.540 30.068 167.855 1.00 9.95 C +ATOM 11944 C LEU H 64 54.226 30.687 167.365 1.00 15.10 C +ATOM 11945 O LEU H 64 53.159 30.481 167.956 1.00 15.99 O +ATOM 11946 CB LEU H 64 55.593 28.589 167.480 1.00 9.24 C +ATOM 11947 CG LEU H 64 55.144 28.143 166.096 1.00 8.90 C +ATOM 11948 CD1 LEU H 64 56.334 27.599 165.346 1.00 17.20 C +ATOM 11949 CD2 LEU H 64 54.063 27.089 166.204 1.00 8.50 C +ATOM 11950 N ILE H 65 54.323 31.477 166.301 1.00 13.91 N +ATOM 11951 CA ILE H 65 53.162 32.122 165.692 1.00 10.41 C +ATOM 11952 C ILE H 65 52.997 31.423 164.350 1.00 13.86 C +ATOM 11953 O ILE H 65 53.925 31.413 163.520 1.00 10.32 O +ATOM 11954 CB ILE H 65 53.408 33.611 165.469 1.00 20.14 C +ATOM 11955 CG1 ILE H 65 53.697 34.304 166.801 1.00 11.43 C +ATOM 11956 CG2 ILE H 65 52.195 34.239 164.786 1.00 17.88 C +ATOM 11957 CD1 ILE H 65 54.239 35.687 166.656 1.00 8.50 C +ATOM 11958 N PHE H 66 51.801 30.888 164.123 1.00 13.29 N +ATOM 11959 CA PHE H 66 51.538 30.104 162.928 1.00 13.67 C +ATOM 11960 C PHE H 66 50.165 30.378 162.373 1.00 9.87 C +ATOM 11961 O PHE H 66 49.253 30.691 163.120 1.00 11.13 O +ATOM 11962 CB PHE H 66 51.617 28.621 163.357 1.00 32.27 C +ATOM 11963 CG PHE H 66 51.641 27.626 162.219 1.00 43.96 C +ATOM 11964 CD1 PHE H 66 50.447 27.098 161.707 1.00 45.11 C +ATOM 11965 CD2 PHE H 66 52.855 27.172 161.700 1.00 37.43 C +ATOM 11966 CE1 PHE H 66 50.462 26.135 160.700 1.00 44.02 C +ATOM 11967 CE2 PHE H 66 52.879 26.210 160.696 1.00 39.03 C +ATOM 11968 CZ PHE H 66 51.678 25.689 160.194 1.00 45.35 C +ATOM 11969 N TRP H 67 50.009 30.232 161.066 1.00 9.48 N +ATOM 11970 CA TRP H 67 48.699 30.390 160.440 1.00 17.78 C +ATOM 11971 C TRP H 67 48.245 28.988 160.038 1.00 23.96 C +ATOM 11972 O TRP H 67 48.871 28.360 159.168 1.00 28.78 O +ATOM 11973 CB TRP H 67 48.768 31.267 159.182 1.00 15.98 C +ATOM 11974 CG TRP H 67 47.523 31.189 158.330 1.00 13.19 C +ATOM 11975 CD1 TRP H 67 47.307 30.371 157.257 1.00 12.92 C +ATOM 11976 CD2 TRP H 67 46.313 31.935 158.511 1.00 19.83 C +ATOM 11977 NE1 TRP H 67 46.038 30.556 156.767 1.00 15.70 N +ATOM 11978 CE2 TRP H 67 45.405 31.513 157.514 1.00 14.71 C +ATOM 11979 CE3 TRP H 67 45.908 32.922 159.417 1.00 25.84 C +ATOM 11980 CZ2 TRP H 67 44.118 32.045 157.400 1.00 10.53 C +ATOM 11981 CZ3 TRP H 67 44.623 33.451 159.301 1.00 26.22 C +ATOM 11982 CH2 TRP H 67 43.746 33.009 158.297 1.00 18.59 C +ATOM 11983 N SER H 68 47.202 28.472 160.690 1.00 23.71 N +ATOM 11984 CA SER H 68 46.693 27.147 160.338 1.00 22.86 C +ATOM 11985 C SER H 68 45.488 27.282 159.396 1.00 17.36 C +ATOM 11986 O SER H 68 44.448 27.853 159.739 1.00 8.50 O +ATOM 11987 CB SER H 68 46.379 26.295 161.583 1.00 25.92 C +ATOM 11988 OG SER H 68 45.264 26.773 162.313 1.00 28.37 O +ATOM 11989 N LYS H 69 45.702 26.805 158.177 1.00 19.69 N +ATOM 11990 CA LYS H 69 44.732 26.849 157.098 1.00 27.59 C +ATOM 11991 C LYS H 69 43.311 26.605 157.582 1.00 25.18 C +ATOM 11992 O LYS H 69 43.084 25.721 158.387 1.00 29.64 O +ATOM 11993 CB LYS H 69 45.139 25.820 156.032 1.00 33.14 C +ATOM 11994 CG LYS H 69 44.664 26.085 154.601 1.00 33.78 C +ATOM 11995 CD LYS H 69 43.190 25.717 154.411 1.00 49.97 C +ATOM 11996 CE LYS H 69 42.843 25.409 152.949 1.00 56.66 C +ATOM 11997 NZ LYS H 69 43.358 24.074 152.512 1.00 58.19 N +ATOM 11998 N ASP H 70 42.375 27.432 157.119 1.00 35.16 N +ATOM 11999 CA ASP H 70 40.952 27.320 157.476 1.00 43.07 C +ATOM 12000 C ASP H 70 40.551 27.617 158.935 1.00 42.82 C +ATOM 12001 O ASP H 70 39.376 27.482 159.300 1.00 45.54 O +ATOM 12002 CB ASP H 70 40.405 25.939 157.073 1.00 50.89 C +ATOM 12003 CG ASP H 70 40.089 25.827 155.582 1.00 56.42 C +ATOM 12004 OD1 ASP H 70 40.028 26.860 154.880 1.00 67.50 O +ATOM 12005 OD2 ASP H 70 39.879 24.688 155.114 1.00 56.99 O +ATOM 12006 N ILE H 71 41.507 28.012 159.767 1.00 39.60 N +ATOM 12007 CA ILE H 71 41.185 28.305 161.154 1.00 33.62 C +ATOM 12008 C ILE H 71 41.520 29.749 161.542 1.00 28.87 C +ATOM 12009 O ILE H 71 40.623 30.534 161.848 1.00 25.35 O +ATOM 12010 CB ILE H 71 41.884 27.309 162.112 1.00 33.23 C +ATOM 12011 CG1 ILE H 71 41.414 25.877 161.822 1.00 35.17 C +ATOM 12012 CG2 ILE H 71 41.587 27.684 163.553 1.00 24.85 C +ATOM 12013 CD1 ILE H 71 42.053 24.818 162.715 1.00 46.05 C +ATOM 12014 N GLY H 72 42.808 30.088 161.517 1.00 21.80 N +ATOM 12015 CA GLY H 72 43.238 31.423 161.880 1.00 11.16 C +ATOM 12016 C GLY H 72 44.649 31.408 162.439 1.00 15.69 C +ATOM 12017 O GLY H 72 45.481 30.576 162.063 1.00 17.35 O +ATOM 12018 N TYR H 73 44.937 32.354 163.323 1.00 12.64 N +ATOM 12019 CA TYR H 73 46.250 32.445 163.940 1.00 9.25 C +ATOM 12020 C TYR H 73 46.368 31.467 165.080 1.00 10.54 C +ATOM 12021 O TYR H 73 45.476 31.362 165.931 1.00 15.79 O +ATOM 12022 CB TYR H 73 46.507 33.863 164.429 1.00 12.71 C +ATOM 12023 CG TYR H 73 46.640 34.832 163.294 1.00 17.38 C +ATOM 12024 CD1 TYR H 73 47.805 34.857 162.514 1.00 16.57 C +ATOM 12025 CD2 TYR H 73 45.591 35.681 162.955 1.00 8.50 C +ATOM 12026 CE1 TYR H 73 47.915 35.705 161.415 1.00 12.02 C +ATOM 12027 CE2 TYR H 73 45.691 36.532 161.858 1.00 13.82 C +ATOM 12028 CZ TYR H 73 46.854 36.537 161.095 1.00 16.48 C +ATOM 12029 OH TYR H 73 46.959 37.383 160.023 1.00 30.06 O +ATOM 12030 N SER H 74 47.479 30.753 165.090 1.00 9.26 N +ATOM 12031 CA SER H 74 47.762 29.763 166.105 1.00 12.78 C +ATOM 12032 C SER H 74 48.951 30.247 166.911 1.00 11.11 C +ATOM 12033 O SER H 74 50.093 30.222 166.435 1.00 12.39 O +ATOM 12034 CB SER H 74 48.086 28.431 165.436 1.00 22.18 C +ATOM 12035 OG SER H 74 48.569 27.481 166.371 1.00 36.41 O +ATOM 12036 N PHE H 75 48.674 30.734 168.114 1.00 10.74 N +ATOM 12037 CA PHE H 75 49.728 31.232 168.982 1.00 11.74 C +ATOM 12038 C PHE H 75 50.042 30.183 170.026 1.00 9.73 C +ATOM 12039 O PHE H 75 49.189 29.835 170.836 1.00 8.88 O +ATOM 12040 CB PHE H 75 49.299 32.531 169.664 1.00 9.06 C +ATOM 12041 CG PHE H 75 50.332 33.090 170.583 1.00 8.50 C +ATOM 12042 CD1 PHE H 75 51.563 33.535 170.088 1.00 8.50 C +ATOM 12043 CD2 PHE H 75 50.091 33.149 171.946 1.00 8.53 C +ATOM 12044 CE1 PHE H 75 52.539 34.031 170.943 1.00 8.50 C +ATOM 12045 CE2 PHE H 75 51.058 33.642 172.816 1.00 19.04 C +ATOM 12046 CZ PHE H 75 52.290 34.086 172.314 1.00 18.55 C +ATOM 12047 N THR H 76 51.272 29.688 170.011 1.00 14.30 N +ATOM 12048 CA THR H 76 51.698 28.664 170.965 1.00 18.24 C +ATOM 12049 C THR H 76 52.968 29.037 171.766 1.00 12.89 C +ATOM 12050 O THR H 76 53.975 29.482 171.212 1.00 8.50 O +ATOM 12051 CB THR H 76 51.838 27.252 170.260 1.00 22.07 C +ATOM 12052 OG1 THR H 76 52.978 26.537 170.764 1.00 18.21 O +ATOM 12053 CG2 THR H 76 51.944 27.402 168.744 1.00 19.13 C +ATOM 12054 N VAL H 77 52.874 28.925 173.084 1.00 10.11 N +ATOM 12055 CA VAL H 77 54.003 29.225 173.942 1.00 18.06 C +ATOM 12056 C VAL H 77 54.179 28.066 174.914 1.00 22.66 C +ATOM 12057 O VAL H 77 53.216 27.637 175.557 1.00 24.62 O +ATOM 12058 CB VAL H 77 53.853 30.607 174.697 1.00 21.02 C +ATOM 12059 CG1 VAL H 77 52.395 30.898 175.019 1.00 15.66 C +ATOM 12060 CG2 VAL H 77 54.720 30.636 175.986 1.00 8.50 C +ATOM 12061 N GLY H 78 55.387 27.503 174.932 1.00 21.79 N +ATOM 12062 CA GLY H 78 55.696 26.389 175.809 1.00 18.54 C +ATOM 12063 C GLY H 78 55.018 25.108 175.369 1.00 21.02 C +ATOM 12064 O GLY H 78 54.562 24.322 176.196 1.00 28.97 O +ATOM 12065 N GLY H 79 54.936 24.902 174.060 1.00 19.80 N +ATOM 12066 CA GLY H 79 54.309 23.699 173.540 1.00 17.83 C +ATOM 12067 C GLY H 79 52.784 23.681 173.589 1.00 19.41 C +ATOM 12068 O GLY H 79 52.165 22.812 172.970 1.00 17.99 O +ATOM 12069 N SER H 80 52.177 24.612 174.329 1.00 20.90 N +ATOM 12070 CA SER H 80 50.716 24.702 174.427 1.00 23.17 C +ATOM 12071 C SER H 80 50.159 25.757 173.457 1.00 23.14 C +ATOM 12072 O SER H 80 50.558 26.928 173.472 1.00 27.08 O +ATOM 12073 CB SER H 80 50.271 24.996 175.868 1.00 26.51 C +ATOM 12074 OG SER H 80 50.579 23.907 176.728 1.00 39.25 O +ATOM 12075 N GLU H 81 49.227 25.312 172.624 1.00 19.19 N +ATOM 12076 CA GLU H 81 48.599 26.126 171.592 1.00 16.38 C +ATOM 12077 C GLU H 81 47.304 26.816 172.021 1.00 16.71 C +ATOM 12078 O GLU H 81 46.649 26.399 172.980 1.00 22.05 O +ATOM 12079 CB GLU H 81 48.337 25.221 170.376 1.00 23.32 C +ATOM 12080 CG GLU H 81 47.684 25.864 169.166 1.00 27.32 C +ATOM 12081 CD GLU H 81 47.196 24.830 168.172 1.00 37.09 C +ATOM 12082 OE1 GLU H 81 46.347 23.989 168.555 1.00 48.84 O +ATOM 12083 OE2 GLU H 81 47.658 24.853 167.014 1.00 39.88 O +ATOM 12084 N ILE H 82 46.949 27.870 171.290 1.00 17.59 N +ATOM 12085 CA ILE H 82 45.741 28.651 171.523 1.00 11.97 C +ATOM 12086 C ILE H 82 45.359 29.229 170.156 1.00 10.63 C +ATOM 12087 O ILE H 82 46.226 29.515 169.320 1.00 8.50 O +ATOM 12088 CB ILE H 82 45.989 29.759 172.578 1.00 8.81 C +ATOM 12089 CG1 ILE H 82 44.695 30.115 173.274 1.00 12.09 C +ATOM 12090 CG2 ILE H 82 46.558 31.001 171.951 1.00 12.63 C +ATOM 12091 CD1 ILE H 82 44.916 30.930 174.509 1.00 20.40 C +ATOM 12092 N LEU H 83 44.070 29.409 169.917 1.00 11.36 N +ATOM 12093 CA LEU H 83 43.643 29.882 168.611 1.00 11.24 C +ATOM 12094 C LEU H 83 42.924 31.205 168.542 1.00 15.45 C +ATOM 12095 O LEU H 83 42.111 31.543 169.407 1.00 19.74 O +ATOM 12096 CB LEU H 83 42.770 28.816 167.947 1.00 16.69 C +ATOM 12097 CG LEU H 83 43.409 27.831 166.955 1.00 23.82 C +ATOM 12098 CD1 LEU H 83 44.733 27.280 167.441 1.00 18.20 C +ATOM 12099 CD2 LEU H 83 42.429 26.697 166.709 1.00 20.78 C +ATOM 12100 N PHE H 84 43.214 31.931 167.470 1.00 13.29 N +ATOM 12101 CA PHE H 84 42.597 33.217 167.196 1.00 15.62 C +ATOM 12102 C PHE H 84 41.990 33.050 165.825 1.00 17.60 C +ATOM 12103 O PHE H 84 42.660 33.151 164.793 1.00 17.12 O +ATOM 12104 CB PHE H 84 43.626 34.340 167.243 1.00 8.90 C +ATOM 12105 CG PHE H 84 44.040 34.687 168.630 1.00 8.50 C +ATOM 12106 CD1 PHE H 84 43.104 35.173 169.536 1.00 12.65 C +ATOM 12107 CD2 PHE H 84 45.331 34.450 169.059 1.00 8.50 C +ATOM 12108 CE1 PHE H 84 43.449 35.411 170.861 1.00 14.24 C +ATOM 12109 CE2 PHE H 84 45.686 34.683 170.375 1.00 8.50 C +ATOM 12110 CZ PHE H 84 44.741 35.164 171.282 1.00 11.82 C +ATOM 12111 N GLU H 85 40.721 32.686 165.844 1.00 17.34 N +ATOM 12112 CA GLU H 85 39.993 32.419 164.638 1.00 23.34 C +ATOM 12113 C GLU H 85 39.840 33.608 163.738 1.00 22.21 C +ATOM 12114 O GLU H 85 39.550 34.701 164.205 1.00 27.53 O +ATOM 12115 CB GLU H 85 38.637 31.831 165.002 1.00 39.97 C +ATOM 12116 CG GLU H 85 38.753 30.675 165.991 1.00 56.33 C +ATOM 12117 CD GLU H 85 37.638 29.668 165.836 1.00 72.01 C +ATOM 12118 OE1 GLU H 85 36.566 29.879 166.441 1.00 86.70 O +ATOM 12119 OE2 GLU H 85 37.832 28.668 165.109 1.00 74.92 O +ATOM 12120 N VAL H 86 40.087 33.382 162.450 1.00 28.17 N +ATOM 12121 CA VAL H 86 39.964 34.397 161.397 1.00 36.90 C +ATOM 12122 C VAL H 86 39.217 33.729 160.234 1.00 47.79 C +ATOM 12123 O VAL H 86 39.818 33.017 159.430 1.00 55.95 O +ATOM 12124 CB VAL H 86 41.346 34.880 160.918 1.00 24.63 C +ATOM 12125 CG1 VAL H 86 41.195 35.781 159.724 1.00 37.86 C +ATOM 12126 CG2 VAL H 86 42.037 35.636 162.032 1.00 42.01 C +ATOM 12127 N PRO H 87 37.894 33.961 160.129 1.00 54.88 N +ATOM 12128 CA PRO H 87 37.015 33.395 159.094 1.00 62.78 C +ATOM 12129 C PRO H 87 37.291 33.832 157.661 1.00 71.88 C +ATOM 12130 O PRO H 87 37.615 33.003 156.806 1.00 76.90 O +ATOM 12131 CB PRO H 87 35.626 33.844 159.549 1.00 64.34 C +ATOM 12132 CG PRO H 87 35.901 35.188 160.177 1.00 57.15 C +ATOM 12133 CD PRO H 87 37.150 34.907 160.984 1.00 59.96 C +ATOM 12134 N GLU H 88 37.111 35.127 157.400 1.00 75.63 N +ATOM 12135 CA GLU H 88 37.325 35.695 156.077 1.00 75.43 C +ATOM 12136 C GLU H 88 38.795 36.118 155.965 1.00 70.14 C +ATOM 12137 O GLU H 88 39.235 37.062 156.625 1.00 67.94 O +ATOM 12138 CB GLU H 88 36.393 36.901 155.882 1.00 86.09 C +ATOM 12139 CG GLU H 88 36.262 37.410 154.442 1.00 99.50 C +ATOM 12140 CD GLU H 88 35.529 38.753 154.340 1.00 99.56 C +ATOM 12141 OE1 GLU H 88 34.517 38.947 155.044 1.00 93.28 O +ATOM 12142 OE2 GLU H 88 35.969 39.616 153.551 1.00101.53 O +ATOM 12143 N VAL H 89 39.569 35.379 155.183 1.00 65.56 N +ATOM 12144 CA VAL H 89 40.976 35.712 155.012 1.00 66.13 C +ATOM 12145 C VAL H 89 41.129 36.655 153.828 1.00 64.59 C +ATOM 12146 O VAL H 89 40.504 36.459 152.783 1.00 63.92 O +ATOM 12147 CB VAL H 89 41.866 34.447 154.812 1.00 71.73 C +ATOM 12148 CG1 VAL H 89 41.561 33.744 153.477 1.00 72.60 C +ATOM 12149 CG2 VAL H 89 43.341 34.822 154.923 1.00 67.05 C +ATOM 12150 N THR H 90 41.929 37.699 154.009 1.00 62.37 N +ATOM 12151 CA THR H 90 42.152 38.679 152.954 1.00 60.00 C +ATOM 12152 C THR H 90 43.625 38.715 152.599 1.00 53.97 C +ATOM 12153 O THR H 90 44.480 38.456 153.451 1.00 60.71 O +ATOM 12154 CB THR H 90 41.670 40.110 153.371 1.00 65.38 C +ATOM 12155 OG1 THR H 90 41.715 40.988 152.236 1.00 73.79 O +ATOM 12156 CG2 THR H 90 42.540 40.689 154.477 1.00 58.00 C +ATOM 12157 N VAL H 91 43.915 39.014 151.337 1.00 43.40 N +ATOM 12158 CA VAL H 91 45.291 39.081 150.857 1.00 40.16 C +ATOM 12159 C VAL H 91 45.773 40.542 150.831 1.00 37.93 C +ATOM 12160 O VAL H 91 45.270 41.367 150.056 1.00 41.34 O +ATOM 12161 CB VAL H 91 45.429 38.403 149.458 1.00 34.25 C +ATOM 12162 CG1 VAL H 91 44.455 39.021 148.474 1.00 43.76 C +ATOM 12163 CG2 VAL H 91 46.858 38.493 148.947 1.00 34.53 C +ATOM 12164 N ALA H 92 46.701 40.861 151.732 1.00 24.67 N +ATOM 12165 CA ALA H 92 47.268 42.196 151.858 1.00 11.26 C +ATOM 12166 C ALA H 92 48.306 42.080 152.938 1.00 11.51 C +ATOM 12167 O ALA H 92 48.288 41.111 153.692 1.00 22.18 O +ATOM 12168 CB ALA H 92 46.211 43.165 152.299 1.00 10.59 C +ATOM 12169 N PRO H 93 49.268 43.018 153.004 1.00 8.50 N +ATOM 12170 CA PRO H 93 50.246 42.867 154.075 1.00 8.92 C +ATOM 12171 C PRO H 93 49.485 42.966 155.385 1.00 12.41 C +ATOM 12172 O PRO H 93 48.453 43.652 155.460 1.00 21.13 O +ATOM 12173 CB PRO H 93 51.152 44.073 153.877 1.00 8.50 C +ATOM 12174 CG PRO H 93 51.118 44.262 152.439 1.00 8.90 C +ATOM 12175 CD PRO H 93 49.648 44.136 152.135 1.00 8.73 C +ATOM 12176 N VAL H 94 49.950 42.239 156.396 1.00 10.82 N +ATOM 12177 CA VAL H 94 49.300 42.254 157.692 1.00 10.43 C +ATOM 12178 C VAL H 94 50.353 42.466 158.773 1.00 11.11 C +ATOM 12179 O VAL H 94 51.520 42.076 158.605 1.00 10.69 O +ATOM 12180 CB VAL H 94 48.443 40.975 157.888 1.00 8.50 C +ATOM 12181 CG1 VAL H 94 49.129 39.802 157.284 1.00 17.71 C +ATOM 12182 CG2 VAL H 94 48.141 40.739 159.341 1.00 8.50 C +ATOM 12183 N HIS H 95 49.977 43.209 159.811 1.00 8.50 N +ATOM 12184 CA HIS H 95 50.887 43.509 160.906 1.00 9.02 C +ATOM 12185 C HIS H 95 50.306 42.921 162.173 1.00 10.76 C +ATOM 12186 O HIS H 95 49.148 43.199 162.496 1.00 16.77 O +ATOM 12187 CB HIS H 95 51.034 45.034 161.044 1.00 14.28 C +ATOM 12188 CG HIS H 95 51.727 45.482 162.298 1.00 9.52 C +ATOM 12189 ND1 HIS H 95 53.091 45.654 162.371 1.00 8.50 N +ATOM 12190 CD2 HIS H 95 51.240 45.792 163.525 1.00 8.50 C +ATOM 12191 CE1 HIS H 95 53.416 46.046 163.588 1.00 8.50 C +ATOM 12192 NE2 HIS H 95 52.311 46.135 164.305 1.00 8.50 N +ATOM 12193 N ILE H 96 51.094 42.120 162.889 1.00 8.50 N +ATOM 12194 CA ILE H 96 50.616 41.531 164.132 1.00 8.50 C +ATOM 12195 C ILE H 96 51.569 41.797 165.299 1.00 9.70 C +ATOM 12196 O ILE H 96 52.771 41.972 165.103 1.00 8.61 O +ATOM 12197 CB ILE H 96 50.408 40.013 164.021 1.00 8.50 C +ATOM 12198 CG1 ILE H 96 51.716 39.338 163.637 1.00 10.89 C +ATOM 12199 CG2 ILE H 96 49.322 39.685 163.026 1.00 8.50 C +ATOM 12200 CD1 ILE H 96 51.670 37.851 163.761 1.00 20.73 C +ATOM 12201 N CYS H 97 50.995 41.943 166.490 1.00 10.72 N +ATOM 12202 CA CYS H 97 51.750 42.136 167.722 1.00 8.50 C +ATOM 12203 C CYS H 97 51.065 41.163 168.644 1.00 9.74 C +ATOM 12204 O CYS H 97 49.829 41.106 168.683 1.00 9.73 O +ATOM 12205 CB CYS H 97 51.589 43.532 168.317 1.00 8.50 C +ATOM 12206 SG CYS H 97 52.628 44.855 167.657 1.00 8.50 S +ATOM 12207 N THR H 98 51.852 40.376 169.362 1.00 10.57 N +ATOM 12208 CA THR H 98 51.295 39.405 170.286 1.00 12.21 C +ATOM 12209 C THR H 98 52.129 39.443 171.562 1.00 10.11 C +ATOM 12210 O THR H 98 53.342 39.683 171.497 1.00 9.44 O +ATOM 12211 CB THR H 98 51.268 38.010 169.648 1.00 13.96 C +ATOM 12212 OG1 THR H 98 50.635 37.093 170.540 1.00 23.16 O +ATOM 12213 CG2 THR H 98 52.675 37.546 169.319 1.00 9.64 C +ATOM 12214 N SER H 99 51.469 39.284 172.713 1.00 11.96 N +ATOM 12215 CA SER H 99 52.149 39.335 174.012 1.00 14.14 C +ATOM 12216 C SER H 99 51.647 38.301 175.027 1.00 14.85 C +ATOM 12217 O SER H 99 50.486 37.882 174.985 1.00 19.72 O +ATOM 12218 CB SER H 99 52.088 40.762 174.603 1.00 12.61 C +ATOM 12219 OG SER H 99 50.760 41.271 174.682 1.00 20.83 O +ATOM 12220 N TRP H 100 52.532 37.902 175.937 1.00 15.42 N +ATOM 12221 CA TRP H 100 52.208 36.912 176.963 1.00 13.96 C +ATOM 12222 C TRP H 100 52.839 37.331 178.291 1.00 13.48 C +ATOM 12223 O TRP H 100 53.929 37.910 178.318 1.00 14.58 O +ATOM 12224 CB TRP H 100 52.722 35.528 176.526 1.00 19.35 C +ATOM 12225 CG TRP H 100 52.763 34.486 177.610 1.00 12.29 C +ATOM 12226 CD1 TRP H 100 51.724 33.722 178.050 1.00 10.36 C +ATOM 12227 CD2 TRP H 100 53.905 34.106 178.390 1.00 8.50 C +ATOM 12228 NE1 TRP H 100 52.149 32.896 179.052 1.00 14.06 N +ATOM 12229 CE2 TRP H 100 53.484 33.112 179.280 1.00 8.50 C +ATOM 12230 CE3 TRP H 100 55.242 34.517 178.420 1.00 8.50 C +ATOM 12231 CZ2 TRP H 100 54.349 32.519 180.193 1.00 16.92 C +ATOM 12232 CZ3 TRP H 100 56.103 33.931 179.323 1.00 9.41 C +ATOM 12233 CH2 TRP H 100 55.656 32.943 180.197 1.00 18.24 C +ATOM 12234 N GLU H 101 52.160 37.017 179.387 1.00 14.03 N +ATOM 12235 CA GLU H 101 52.625 37.368 180.724 1.00 15.75 C +ATOM 12236 C GLU H 101 52.514 36.147 181.632 1.00 20.57 C +ATOM 12237 O GLU H 101 51.406 35.656 181.872 1.00 24.29 O +ATOM 12238 CB GLU H 101 51.743 38.490 181.272 1.00 20.58 C +ATOM 12239 CG GLU H 101 52.021 38.897 182.709 1.00 27.58 C +ATOM 12240 CD GLU H 101 51.059 39.976 183.215 1.00 28.38 C +ATOM 12241 OE1 GLU H 101 49.880 39.654 183.500 1.00 20.15 O +ATOM 12242 OE2 GLU H 101 51.494 41.145 183.341 1.00 34.58 O +ATOM 12243 N SER H 102 53.643 35.673 182.156 1.00 20.58 N +ATOM 12244 CA SER H 102 53.637 34.497 183.033 1.00 18.81 C +ATOM 12245 C SER H 102 52.718 34.676 184.229 1.00 18.36 C +ATOM 12246 O SER H 102 51.889 33.808 184.510 1.00 21.68 O +ATOM 12247 CB SER H 102 55.051 34.174 183.522 1.00 18.57 C +ATOM 12248 OG SER H 102 55.024 33.218 184.575 1.00 10.27 O +ATOM 12249 N ALA H 103 52.817 35.836 184.874 1.00 14.66 N +ATOM 12250 CA ALA H 103 52.024 36.141 186.063 1.00 14.74 C +ATOM 12251 C ALA H 103 50.513 35.902 186.011 1.00 15.64 C +ATOM 12252 O ALA H 103 49.903 35.633 187.052 1.00 23.28 O +ATOM 12253 CB ALA H 103 52.306 37.547 186.529 1.00 16.64 C +ATOM 12254 N SER H 104 49.907 35.983 184.826 1.00 13.68 N +ATOM 12255 CA SER H 104 48.448 35.787 184.709 1.00 14.61 C +ATOM 12256 C SER H 104 48.044 34.826 183.588 1.00 12.53 C +ATOM 12257 O SER H 104 46.913 34.307 183.559 1.00 8.50 O +ATOM 12258 CB SER H 104 47.767 37.136 184.458 1.00 12.78 C +ATOM 12259 OG SER H 104 48.161 37.651 183.195 1.00 11.44 O +ATOM 12260 N GLY H 105 48.970 34.632 182.652 1.00 14.85 N +ATOM 12261 CA GLY H 105 48.727 33.771 181.509 1.00 13.36 C +ATOM 12262 C GLY H 105 47.976 34.512 180.421 1.00 17.21 C +ATOM 12263 O GLY H 105 47.640 33.925 179.398 1.00 19.50 O +ATOM 12264 N ILE H 106 47.716 35.804 180.626 1.00 17.43 N +ATOM 12265 CA ILE H 106 46.991 36.578 179.629 1.00 10.40 C +ATOM 12266 C ILE H 106 47.826 36.847 178.399 1.00 9.05 C +ATOM 12267 O ILE H 106 48.920 37.413 178.468 1.00 13.85 O +ATOM 12268 CB ILE H 106 46.481 37.920 180.180 1.00 13.53 C +ATOM 12269 CG1 ILE H 106 45.445 37.676 181.278 1.00 13.70 C +ATOM 12270 CG2 ILE H 106 45.834 38.711 179.069 1.00 8.50 C +ATOM 12271 CD1 ILE H 106 44.863 38.923 181.847 1.00 11.81 C +ATOM 12272 N VAL H 107 47.296 36.422 177.269 1.00 8.68 N +ATOM 12273 CA VAL H 107 47.943 36.628 175.990 1.00 10.18 C +ATOM 12274 C VAL H 107 47.007 37.492 175.134 1.00 11.91 C +ATOM 12275 O VAL H 107 45.785 37.265 175.119 1.00 10.72 O +ATOM 12276 CB VAL H 107 48.277 35.276 175.287 1.00 15.03 C +ATOM 12277 CG1 VAL H 107 47.160 34.263 175.478 1.00 11.02 C +ATOM 12278 CG2 VAL H 107 48.511 35.490 173.809 1.00 17.71 C +ATOM 12279 N GLU H 108 47.570 38.540 174.519 1.00 14.34 N +ATOM 12280 CA GLU H 108 46.827 39.467 173.654 1.00 9.91 C +ATOM 12281 C GLU H 108 47.313 39.214 172.229 1.00 10.50 C +ATOM 12282 O GLU H 108 48.478 38.862 172.019 1.00 8.50 O +ATOM 12283 CB GLU H 108 47.166 40.931 173.986 1.00 9.11 C +ATOM 12284 CG GLU H 108 46.783 41.474 175.358 1.00 13.04 C +ATOM 12285 CD GLU H 108 47.411 42.848 175.654 1.00 19.66 C +ATOM 12286 OE1 GLU H 108 48.216 43.357 174.846 1.00 21.15 O +ATOM 12287 OE2 GLU H 108 47.127 43.429 176.718 1.00 24.91 O +ATOM 12288 N PHE H 109 46.434 39.404 171.253 1.00 11.99 N +ATOM 12289 CA PHE H 109 46.815 39.243 169.859 1.00 9.97 C +ATOM 12290 C PHE H 109 46.203 40.447 169.165 1.00 10.40 C +ATOM 12291 O PHE H 109 44.998 40.670 169.261 1.00 8.50 O +ATOM 12292 CB PHE H 109 46.249 37.952 169.281 1.00 8.94 C +ATOM 12293 CG PHE H 109 47.045 37.405 168.121 1.00 15.03 C +ATOM 12294 CD1 PHE H 109 48.159 36.593 168.338 1.00 11.31 C +ATOM 12295 CD2 PHE H 109 46.679 37.694 166.815 1.00 16.42 C +ATOM 12296 CE1 PHE H 109 48.886 36.081 167.283 1.00 8.50 C +ATOM 12297 CE2 PHE H 109 47.403 37.185 165.743 1.00 12.22 C +ATOM 12298 CZ PHE H 109 48.511 36.374 165.983 1.00 16.52 C +ATOM 12299 N TRP H 110 47.054 41.284 168.577 1.00 13.30 N +ATOM 12300 CA TRP H 110 46.607 42.488 167.876 1.00 12.53 C +ATOM 12301 C TRP H 110 46.874 42.323 166.400 1.00 9.56 C +ATOM 12302 O TRP H 110 48.020 42.150 165.995 1.00 10.39 O +ATOM 12303 CB TRP H 110 47.394 43.721 168.337 1.00 15.45 C +ATOM 12304 CG TRP H 110 47.229 44.059 169.767 1.00 17.23 C +ATOM 12305 CD1 TRP H 110 47.701 43.359 170.830 1.00 14.81 C +ATOM 12306 CD2 TRP H 110 46.525 45.184 170.303 1.00 18.34 C +ATOM 12307 NE1 TRP H 110 47.334 43.972 171.998 1.00 18.05 N +ATOM 12308 CE2 TRP H 110 46.609 45.096 171.705 1.00 21.15 C +ATOM 12309 CE3 TRP H 110 45.832 46.259 169.735 1.00 15.83 C +ATOM 12310 CZ2 TRP H 110 46.021 46.043 172.552 1.00 21.52 C +ATOM 12311 CZ3 TRP H 110 45.251 47.201 170.575 1.00 12.98 C +ATOM 12312 CH2 TRP H 110 45.348 47.086 171.967 1.00 16.92 C +ATOM 12313 N VAL H 111 45.828 42.398 165.593 1.00 8.52 N +ATOM 12314 CA VAL H 111 45.992 42.282 164.155 1.00 8.50 C +ATOM 12315 C VAL H 111 45.647 43.625 163.544 1.00 11.99 C +ATOM 12316 O VAL H 111 44.537 44.143 163.731 1.00 14.82 O +ATOM 12317 CB VAL H 111 45.088 41.213 163.561 1.00 8.50 C +ATOM 12318 CG1 VAL H 111 45.336 41.091 162.075 1.00 9.13 C +ATOM 12319 CG2 VAL H 111 45.353 39.890 164.225 1.00 23.00 C +ATOM 12320 N ASP H 112 46.624 44.205 162.851 1.00 12.70 N +ATOM 12321 CA ASP H 112 46.481 45.510 162.199 1.00 9.92 C +ATOM 12322 C ASP H 112 46.045 46.631 163.130 1.00 9.34 C +ATOM 12323 O ASP H 112 45.199 47.454 162.772 1.00 9.02 O +ATOM 12324 CB ASP H 112 45.543 45.439 160.990 1.00 9.36 C +ATOM 12325 CG ASP H 112 46.235 44.922 159.741 1.00 12.46 C +ATOM 12326 OD1 ASP H 112 47.463 45.147 159.597 1.00 9.74 O +ATOM 12327 OD2 ASP H 112 45.541 44.301 158.895 1.00 17.52 O +ATOM 12328 N GLY H 113 46.632 46.655 164.325 1.00 11.87 N +ATOM 12329 CA GLY H 113 46.326 47.697 165.291 1.00 11.24 C +ATOM 12330 C GLY H 113 45.064 47.528 166.104 1.00 11.62 C +ATOM 12331 O GLY H 113 44.805 48.318 167.013 1.00 14.63 O +ATOM 12332 N LYS H 114 44.271 46.521 165.764 1.00 9.53 N +ATOM 12333 CA LYS H 114 43.035 46.251 166.466 1.00 10.43 C +ATOM 12334 C LYS H 114 43.184 44.946 167.276 1.00 12.16 C +ATOM 12335 O LYS H 114 43.630 43.919 166.758 1.00 12.54 O +ATOM 12336 CB LYS H 114 41.877 46.294 165.447 1.00 16.43 C +ATOM 12337 CG LYS H 114 41.845 47.685 164.788 1.00 13.22 C +ATOM 12338 CD LYS H 114 40.756 47.977 163.754 1.00 42.28 C +ATOM 12339 CE LYS H 114 40.997 49.416 163.181 1.00 68.42 C +ATOM 12340 NZ LYS H 114 39.913 50.123 162.375 1.00 65.70 N +ATOM 12341 N PRO H 115 42.866 44.997 168.584 1.00 12.99 N +ATOM 12342 CA PRO H 115 42.960 43.873 169.510 1.00 10.17 C +ATOM 12343 C PRO H 115 41.868 42.810 169.427 1.00 11.71 C +ATOM 12344 O PRO H 115 40.692 43.118 169.228 1.00 9.15 O +ATOM 12345 CB PRO H 115 42.899 44.571 170.853 1.00 8.50 C +ATOM 12346 CG PRO H 115 41.839 45.586 170.603 1.00 8.50 C +ATOM 12347 CD PRO H 115 42.248 46.161 169.260 1.00 14.59 C +ATOM 12348 N ARG H 116 42.293 41.562 169.594 1.00 12.14 N +ATOM 12349 CA ARG H 116 41.395 40.420 169.643 1.00 10.20 C +ATOM 12350 C ARG H 116 41.204 40.294 171.164 1.00 13.23 C +ATOM 12351 O ARG H 116 41.953 40.904 171.947 1.00 12.29 O +ATOM 12352 CB ARG H 116 42.094 39.178 169.105 1.00 10.75 C +ATOM 12353 CG ARG H 116 42.637 39.334 167.719 1.00 17.24 C +ATOM 12354 CD ARG H 116 41.529 39.287 166.678 1.00 39.77 C +ATOM 12355 NE ARG H 116 41.060 37.918 166.449 1.00 43.26 N +ATOM 12356 CZ ARG H 116 39.968 37.407 166.993 1.00 45.20 C +ATOM 12357 NH1 ARG H 116 39.219 38.158 167.804 1.00 48.33 N +ATOM 12358 NH2 ARG H 116 39.632 36.150 166.731 1.00 42.45 N +ATOM 12359 N VAL H 117 40.240 39.491 171.595 1.00 14.45 N +ATOM 12360 CA VAL H 117 39.994 39.341 173.027 1.00 11.74 C +ATOM 12361 C VAL H 117 41.190 38.736 173.741 1.00 17.08 C +ATOM 12362 O VAL H 117 42.065 38.141 173.104 1.00 21.20 O +ATOM 12363 CB VAL H 117 38.780 38.473 173.324 1.00 8.50 C +ATOM 12364 CG1 VAL H 117 38.235 38.844 174.693 1.00 14.28 C +ATOM 12365 CG2 VAL H 117 37.709 38.641 172.258 1.00 11.01 C +ATOM 12366 N ARG H 118 41.245 38.925 175.059 1.00 18.21 N +ATOM 12367 CA ARG H 118 42.349 38.394 175.860 1.00 15.65 C +ATOM 12368 C ARG H 118 42.071 36.946 176.251 1.00 12.39 C +ATOM 12369 O ARG H 118 40.964 36.606 176.655 1.00 16.44 O +ATOM 12370 CB ARG H 118 42.560 39.232 177.121 1.00 9.58 C +ATOM 12371 CG ARG H 118 42.847 40.681 176.870 1.00 10.17 C +ATOM 12372 CD ARG H 118 43.362 41.307 178.141 1.00 23.68 C +ATOM 12373 NE ARG H 118 42.909 42.683 178.335 1.00 18.62 N +ATOM 12374 CZ ARG H 118 43.698 43.746 178.244 1.00 14.08 C +ATOM 12375 NH1 ARG H 118 44.983 43.611 177.955 1.00 8.50 N +ATOM 12376 NH2 ARG H 118 43.199 44.943 178.460 1.00 11.48 N +ATOM 12377 N LYS H 119 43.089 36.106 176.158 1.00 12.26 N +ATOM 12378 CA LYS H 119 42.938 34.710 176.497 1.00 11.14 C +ATOM 12379 C LYS H 119 43.997 34.300 177.513 1.00 12.87 C +ATOM 12380 O LYS H 119 44.941 35.050 177.771 1.00 15.44 O +ATOM 12381 CB LYS H 119 43.023 33.876 175.218 1.00 16.51 C +ATOM 12382 CG LYS H 119 41.864 34.162 174.267 1.00 13.15 C +ATOM 12383 CD LYS H 119 41.848 33.230 173.075 1.00 13.39 C +ATOM 12384 CE LYS H 119 40.522 33.363 172.334 1.00 27.72 C +ATOM 12385 NZ LYS H 119 40.433 32.490 171.121 1.00 35.57 N +ATOM 12386 N SER H 120 43.814 33.140 178.135 1.00 16.50 N +ATOM 12387 CA SER H 120 44.765 32.650 179.134 1.00 14.08 C +ATOM 12388 C SER H 120 45.577 31.501 178.550 1.00 8.65 C +ATOM 12389 O SER H 120 45.034 30.649 177.848 1.00 9.66 O +ATOM 12390 CB SER H 120 44.006 32.194 180.387 1.00 21.08 C +ATOM 12391 OG SER H 120 44.844 32.147 181.529 1.00 27.28 O +ATOM 12392 N LEU H 121 46.868 31.478 178.847 1.00 8.50 N +ATOM 12393 CA LEU H 121 47.734 30.437 178.331 1.00 12.50 C +ATOM 12394 C LEU H 121 49.072 30.376 179.063 1.00 18.93 C +ATOM 12395 O LEU H 121 49.748 31.399 179.223 1.00 19.86 O +ATOM 12396 CB LEU H 121 47.953 30.648 176.827 1.00 13.06 C +ATOM 12397 CG LEU H 121 49.051 29.848 176.128 1.00 18.45 C +ATOM 12398 CD1 LEU H 121 48.819 28.361 176.298 1.00 17.95 C +ATOM 12399 CD2 LEU H 121 49.079 30.211 174.657 1.00 19.32 C +ATOM 12400 N LYS H 122 49.417 29.174 179.532 1.00 19.70 N +ATOM 12401 CA LYS H 122 50.670 28.905 180.240 1.00 15.00 C +ATOM 12402 C LYS H 122 51.015 29.804 181.419 1.00 17.57 C +ATOM 12403 O LYS H 122 52.158 30.285 181.523 1.00 14.88 O +ATOM 12404 CB LYS H 122 51.846 28.889 179.263 1.00 14.93 C +ATOM 12405 CG LYS H 122 52.019 27.560 178.551 1.00 26.44 C +ATOM 12406 CD LYS H 122 52.490 26.466 179.497 1.00 22.88 C +ATOM 12407 CE LYS H 122 52.659 25.157 178.764 1.00 27.06 C +ATOM 12408 NZ LYS H 122 53.182 24.090 179.648 1.00 45.53 N +ATOM 12409 N LYS H 123 50.055 30.003 182.326 1.00 17.63 N +ATOM 12410 CA LYS H 123 50.314 30.846 183.500 1.00 19.17 C +ATOM 12411 C LYS H 123 51.423 30.219 184.359 1.00 22.31 C +ATOM 12412 O LYS H 123 51.518 28.993 184.478 1.00 27.63 O +ATOM 12413 CB LYS H 123 49.054 31.034 184.356 1.00 16.88 C +ATOM 12414 CG LYS H 123 49.317 31.880 185.588 1.00 8.50 C +ATOM 12415 CD LYS H 123 48.384 31.558 186.727 1.00 13.67 C +ATOM 12416 CE LYS H 123 47.011 32.177 186.550 1.00 10.13 C +ATOM 12417 NZ LYS H 123 46.278 32.137 187.847 1.00 12.57 N +ATOM 12418 N GLY H 124 52.272 31.058 184.935 1.00 22.02 N +ATOM 12419 CA GLY H 124 53.340 30.543 185.764 1.00 21.45 C +ATOM 12420 C GLY H 124 54.529 29.969 185.005 1.00 22.25 C +ATOM 12421 O GLY H 124 55.604 29.771 185.594 1.00 28.79 O +ATOM 12422 N TYR H 125 54.359 29.700 183.713 1.00 15.63 N +ATOM 12423 CA TYR H 125 55.453 29.161 182.910 1.00 20.23 C +ATOM 12424 C TYR H 125 56.579 30.205 182.810 1.00 24.34 C +ATOM 12425 O TYR H 125 56.428 31.350 183.253 1.00 28.94 O +ATOM 12426 CB TYR H 125 54.943 28.800 181.502 1.00 25.66 C +ATOM 12427 CG TYR H 125 55.943 28.062 180.623 1.00 26.16 C +ATOM 12428 CD1 TYR H 125 56.115 26.684 180.743 1.00 32.76 C +ATOM 12429 CD2 TYR H 125 56.714 28.742 179.671 1.00 28.02 C +ATOM 12430 CE1 TYR H 125 57.031 25.998 179.941 1.00 35.15 C +ATOM 12431 CE2 TYR H 125 57.633 28.066 178.866 1.00 27.93 C +ATOM 12432 CZ TYR H 125 57.787 26.695 179.007 1.00 32.63 C +ATOM 12433 OH TYR H 125 58.694 26.007 178.226 1.00 37.71 O +ATOM 12434 N THR H 126 57.714 29.809 182.252 1.00 22.91 N +ATOM 12435 CA THR H 126 58.833 30.722 182.083 1.00 23.21 C +ATOM 12436 C THR H 126 59.612 30.281 180.832 1.00 25.18 C +ATOM 12437 O THR H 126 60.032 29.120 180.710 1.00 25.77 O +ATOM 12438 CB THR H 126 59.693 30.802 183.381 1.00 21.96 C +ATOM 12439 OG1 THR H 126 61.002 31.302 183.075 1.00 28.30 O +ATOM 12440 CG2 THR H 126 59.783 29.422 184.083 1.00 34.08 C +ATOM 12441 N VAL H 127 59.693 31.190 179.862 1.00 23.40 N +ATOM 12442 CA VAL H 127 60.353 30.931 178.586 1.00 18.15 C +ATOM 12443 C VAL H 127 61.873 30.862 178.689 1.00 14.22 C +ATOM 12444 O VAL H 127 62.481 31.669 179.363 1.00 9.78 O +ATOM 12445 CB VAL H 127 59.900 31.977 177.522 1.00 16.46 C +ATOM 12446 CG1 VAL H 127 60.648 31.793 176.215 1.00 21.85 C +ATOM 12447 CG2 VAL H 127 58.402 31.850 177.279 1.00 10.89 C +ATOM 12448 N GLY H 128 62.462 29.890 177.993 1.00 18.42 N +ATOM 12449 CA GLY H 128 63.900 29.685 177.992 1.00 25.58 C +ATOM 12450 C GLY H 128 64.678 30.829 177.382 1.00 29.18 C +ATOM 12451 O GLY H 128 64.255 31.389 176.382 1.00 30.20 O +ATOM 12452 N ALA H 129 65.837 31.131 177.968 1.00 33.52 N +ATOM 12453 CA ALA H 129 66.694 32.234 177.539 1.00 32.48 C +ATOM 12454 C ALA H 129 67.598 31.968 176.342 1.00 39.65 C +ATOM 12455 O ALA H 129 67.853 32.876 175.550 1.00 42.66 O +ATOM 12456 CB ALA H 129 67.514 32.732 178.710 1.00 32.63 C +ATOM 12457 N GLU H 130 68.148 30.761 176.240 1.00 44.05 N +ATOM 12458 CA GLU H 130 69.010 30.441 175.108 1.00 49.78 C +ATOM 12459 C GLU H 130 68.144 29.780 174.052 1.00 45.63 C +ATOM 12460 O GLU H 130 67.676 28.653 174.232 1.00 42.70 O +ATOM 12461 CB GLU H 130 70.174 29.543 175.523 1.00 60.94 C +ATOM 12462 CG GLU H 130 69.781 28.270 176.234 1.00 88.69 C +ATOM 12463 CD GLU H 130 70.990 27.429 176.604 1.00103.83 C +ATOM 12464 OE1 GLU H 130 71.558 27.655 177.696 1.00110.13 O +ATOM 12465 OE2 GLU H 130 71.377 26.548 175.800 1.00112.73 O +ATOM 12466 N ALA H 131 67.928 30.491 172.948 1.00 43.44 N +ATOM 12467 CA ALA H 131 67.064 29.975 171.903 1.00 33.46 C +ATOM 12468 C ALA H 131 67.501 30.254 170.474 1.00 25.46 C +ATOM 12469 O ALA H 131 68.308 31.160 170.209 1.00 29.26 O +ATOM 12470 CB ALA H 131 65.652 30.508 172.117 1.00 33.96 C +ATOM 12471 N SER H 132 66.952 29.448 169.569 1.00 15.45 N +ATOM 12472 CA SER H 132 67.189 29.573 168.145 1.00 20.41 C +ATOM 12473 C SER H 132 65.898 30.198 167.622 1.00 24.42 C +ATOM 12474 O SER H 132 64.817 29.608 167.770 1.00 24.50 O +ATOM 12475 CB SER H 132 67.407 28.198 167.508 1.00 15.29 C +ATOM 12476 OG SER H 132 67.584 28.277 166.102 1.00 10.11 O +ATOM 12477 N ILE H 133 66.008 31.421 167.096 1.00 22.15 N +ATOM 12478 CA ILE H 133 64.870 32.163 166.554 1.00 14.70 C +ATOM 12479 C ILE H 133 64.973 32.148 165.032 1.00 14.73 C +ATOM 12480 O ILE H 133 65.914 32.705 164.462 1.00 21.10 O +ATOM 12481 CB ILE H 133 64.891 33.619 167.062 1.00 16.15 C +ATOM 12482 CG1 ILE H 133 64.962 33.628 168.591 1.00 15.18 C +ATOM 12483 CG2 ILE H 133 63.663 34.372 166.585 1.00 14.18 C +ATOM 12484 CD1 ILE H 133 65.079 34.995 169.180 1.00 8.50 C +ATOM 12485 N ILE H 134 64.014 31.517 164.370 1.00 9.11 N +ATOM 12486 CA ILE H 134 64.064 31.436 162.924 1.00 11.24 C +ATOM 12487 C ILE H 134 62.855 31.998 162.215 1.00 13.05 C +ATOM 12488 O ILE H 134 61.713 31.865 162.672 1.00 14.38 O +ATOM 12489 CB ILE H 134 64.372 29.998 162.463 1.00 19.37 C +ATOM 12490 CG1 ILE H 134 65.858 29.715 162.692 1.00 15.44 C +ATOM 12491 CG2 ILE H 134 63.964 29.760 160.994 1.00 13.61 C +ATOM 12492 CD1 ILE H 134 66.270 28.325 162.324 1.00 34.12 C +ATOM 12493 N LEU H 135 63.139 32.647 161.089 1.00 13.32 N +ATOM 12494 CA LEU H 135 62.133 33.276 160.254 1.00 14.16 C +ATOM 12495 C LEU H 135 61.977 32.487 158.968 1.00 13.69 C +ATOM 12496 O LEU H 135 62.976 32.110 158.355 1.00 8.50 O +ATOM 12497 CB LEU H 135 62.572 34.713 159.925 1.00 14.55 C +ATOM 12498 CG LEU H 135 61.997 35.900 160.715 1.00 10.53 C +ATOM 12499 CD1 LEU H 135 61.815 35.558 162.188 1.00 16.24 C +ATOM 12500 CD2 LEU H 135 62.922 37.089 160.547 1.00 8.76 C +ATOM 12501 N GLY H 136 60.729 32.204 158.590 1.00 18.34 N +ATOM 12502 CA GLY H 136 60.478 31.489 157.348 1.00 24.21 C +ATOM 12503 C GLY H 136 60.403 29.966 157.352 1.00 29.12 C +ATOM 12504 O GLY H 136 59.962 29.381 156.355 1.00 24.98 O +ATOM 12505 N GLN H 137 60.877 29.314 158.421 1.00 29.33 N +ATOM 12506 CA GLN H 137 60.833 27.854 158.522 1.00 15.52 C +ATOM 12507 C GLN H 137 60.245 27.442 159.843 1.00 16.26 C +ATOM 12508 O GLN H 137 60.234 28.230 160.788 1.00 20.98 O +ATOM 12509 CB GLN H 137 62.221 27.242 158.387 1.00 13.11 C +ATOM 12510 CG GLN H 137 62.707 27.085 156.954 1.00 14.26 C +ATOM 12511 CD GLN H 137 61.723 26.360 156.062 1.00 26.36 C +ATOM 12512 OE1 GLN H 137 61.779 26.493 154.839 1.00 29.00 O +ATOM 12513 NE2 GLN H 137 60.829 25.567 156.662 1.00 26.70 N +ATOM 12514 N GLU H 138 59.735 26.217 159.908 1.00 16.80 N +ATOM 12515 CA GLU H 138 59.155 25.719 161.147 1.00 22.79 C +ATOM 12516 C GLU H 138 60.130 24.785 161.876 1.00 25.23 C +ATOM 12517 O GLU H 138 60.424 23.682 161.395 1.00 23.96 O +ATOM 12518 CB GLU H 138 57.835 24.998 160.875 1.00 22.19 C +ATOM 12519 CG GLU H 138 56.862 25.003 162.062 1.00 24.43 C +ATOM 12520 CD GLU H 138 57.301 24.126 163.243 1.00 40.68 C +ATOM 12521 OE1 GLU H 138 56.998 22.907 163.236 1.00 44.53 O +ATOM 12522 OE2 GLU H 138 57.918 24.663 164.197 1.00 44.99 O +ATOM 12523 N GLN H 139 60.623 25.239 163.032 1.00 26.07 N +ATOM 12524 CA GLN H 139 61.549 24.457 163.851 1.00 27.70 C +ATOM 12525 C GLN H 139 60.889 23.304 164.608 1.00 36.65 C +ATOM 12526 O GLN H 139 59.841 23.461 165.267 1.00 26.95 O +ATOM 12527 CB GLN H 139 62.280 25.332 164.861 1.00 13.12 C +ATOM 12528 CG GLN H 139 63.632 25.791 164.410 1.00 21.79 C +ATOM 12529 CD GLN H 139 64.095 27.007 165.185 1.00 24.57 C +ATOM 12530 OE1 GLN H 139 63.786 28.133 164.821 1.00 42.38 O +ATOM 12531 NE2 GLN H 139 64.800 26.787 166.268 1.00 8.50 N +ATOM 12532 N ASP H 140 61.535 22.143 164.510 1.00 43.62 N +ATOM 12533 CA ASP H 140 61.085 20.934 165.178 1.00 43.46 C +ATOM 12534 C ASP H 140 62.252 20.331 165.922 1.00 45.30 C +ATOM 12535 O ASP H 140 62.169 19.220 166.434 1.00 55.22 O +ATOM 12536 CB ASP H 140 60.464 19.950 164.193 1.00 42.44 C +ATOM 12537 CG ASP H 140 59.115 20.431 163.686 1.00 50.79 C +ATOM 12538 OD1 ASP H 140 58.338 20.954 164.520 1.00 48.93 O +ATOM 12539 OD2 ASP H 140 58.847 20.321 162.467 1.00 47.52 O +ATOM 12540 N SER H 141 63.334 21.099 165.987 1.00 42.13 N +ATOM 12541 CA SER H 141 64.543 20.736 166.710 1.00 41.11 C +ATOM 12542 C SER H 141 65.335 22.028 166.765 1.00 38.88 C +ATOM 12543 O SER H 141 65.169 22.893 165.899 1.00 44.43 O +ATOM 12544 CB SER H 141 65.337 19.653 165.980 1.00 43.31 C +ATOM 12545 OG SER H 141 66.145 20.194 164.950 1.00 42.27 O +ATOM 12546 N PHE H 142 66.161 22.185 167.790 1.00 34.78 N +ATOM 12547 CA PHE H 142 66.959 23.398 167.944 1.00 34.56 C +ATOM 12548 C PHE H 142 67.737 23.747 166.667 1.00 36.80 C +ATOM 12549 O PHE H 142 68.750 23.122 166.347 1.00 39.55 O +ATOM 12550 CB PHE H 142 67.917 23.244 169.123 1.00 36.74 C +ATOM 12551 CG PHE H 142 68.550 24.525 169.572 1.00 32.81 C +ATOM 12552 CD1 PHE H 142 67.914 25.335 170.511 1.00 39.29 C +ATOM 12553 CD2 PHE H 142 69.809 24.892 169.112 1.00 36.11 C +ATOM 12554 CE1 PHE H 142 68.530 26.495 170.995 1.00 48.10 C +ATOM 12555 CE2 PHE H 142 70.435 26.051 169.585 1.00 45.40 C +ATOM 12556 CZ PHE H 142 69.797 26.852 170.529 1.00 49.16 C +ATOM 12557 N GLY H 143 67.216 24.723 165.926 1.00 38.89 N +ATOM 12558 CA GLY H 143 67.853 25.181 164.705 1.00 35.23 C +ATOM 12559 C GLY H 143 67.713 24.307 163.476 1.00 34.37 C +ATOM 12560 O GLY H 143 68.424 24.528 162.487 1.00 29.41 O +ATOM 12561 N GLY H 144 66.782 23.354 163.508 1.00 33.54 N +ATOM 12562 CA GLY H 144 66.609 22.472 162.368 1.00 39.73 C +ATOM 12563 C GLY H 144 65.310 21.688 162.310 1.00 44.21 C +ATOM 12564 O GLY H 144 64.341 21.994 163.024 1.00 45.82 O +ATOM 12565 N ASN H 145 65.308 20.661 161.456 1.00 47.25 N +ATOM 12566 CA ASN H 145 64.150 19.786 161.238 1.00 49.35 C +ATOM 12567 C ASN H 145 63.003 20.580 160.616 1.00 45.51 C +ATOM 12568 O ASN H 145 61.886 20.638 161.139 1.00 46.30 O +ATOM 12569 CB ASN H 145 63.715 19.095 162.547 1.00 63.82 C +ATOM 12570 CG ASN H 145 64.562 17.858 162.877 1.00 68.78 C +ATOM 12571 OD1 ASN H 145 65.774 17.949 163.074 1.00 70.50 O +ATOM 12572 ND2 ASN H 145 63.919 16.699 162.933 1.00 70.18 N +ATOM 12573 N PHE H 146 63.290 21.162 159.459 1.00 42.24 N +ATOM 12574 CA PHE H 146 62.323 21.989 158.748 1.00 42.28 C +ATOM 12575 C PHE H 146 61.370 21.219 157.833 1.00 45.81 C +ATOM 12576 O PHE H 146 61.804 20.453 156.967 1.00 51.14 O +ATOM 12577 CB PHE H 146 63.062 23.054 157.922 1.00 29.38 C +ATOM 12578 CG PHE H 146 64.023 23.894 158.720 1.00 19.42 C +ATOM 12579 CD1 PHE H 146 63.692 24.337 159.993 1.00 12.31 C +ATOM 12580 CD2 PHE H 146 65.266 24.237 158.195 1.00 17.68 C +ATOM 12581 CE1 PHE H 146 64.579 25.100 160.720 1.00 11.89 C +ATOM 12582 CE2 PHE H 146 66.161 25.002 158.920 1.00 8.50 C +ATOM 12583 CZ PHE H 146 65.822 25.433 160.177 1.00 10.15 C +ATOM 12584 N GLU H 147 60.071 21.409 158.037 1.00 46.49 N +ATOM 12585 CA GLU H 147 59.072 20.776 157.182 1.00 50.03 C +ATOM 12586 C GLU H 147 58.709 21.815 156.118 1.00 48.58 C +ATOM 12587 O GLU H 147 58.224 22.908 156.440 1.00 49.84 O +ATOM 12588 CB GLU H 147 57.819 20.432 157.980 1.00 61.17 C +ATOM 12589 CG GLU H 147 58.063 19.687 159.279 1.00 83.90 C +ATOM 12590 CD GLU H 147 56.766 19.271 159.978 1.00 99.90 C +ATOM 12591 OE1 GLU H 147 55.665 19.437 159.398 1.00109.59 O +ATOM 12592 OE2 GLU H 147 56.846 18.764 161.118 1.00110.56 O +ATOM 12593 N GLY H 148 58.953 21.479 154.856 1.00 47.99 N +ATOM 12594 CA GLY H 148 58.658 22.393 153.763 1.00 47.63 C +ATOM 12595 C GLY H 148 57.192 22.758 153.599 1.00 46.12 C +ATOM 12596 O GLY H 148 56.864 23.736 152.928 1.00 48.60 O +ATOM 12597 N SER H 149 56.318 21.960 154.207 1.00 44.62 N +ATOM 12598 CA SER H 149 54.871 22.167 154.168 1.00 45.27 C +ATOM 12599 C SER H 149 54.463 23.296 155.139 1.00 39.64 C +ATOM 12600 O SER H 149 53.285 23.659 155.261 1.00 40.59 O +ATOM 12601 CB SER H 149 54.176 20.850 154.564 1.00 59.18 C +ATOM 12602 OG SER H 149 52.761 20.916 154.432 1.00 80.02 O +ATOM 12603 N GLN H 150 55.451 23.841 155.835 1.00 29.84 N +ATOM 12604 CA GLN H 150 55.209 24.892 156.796 1.00 22.90 C +ATOM 12605 C GLN H 150 56.178 26.044 156.581 1.00 28.90 C +ATOM 12606 O GLN H 150 56.387 26.871 157.468 1.00 34.55 O +ATOM 12607 CB GLN H 150 55.361 24.329 158.205 1.00 28.75 C +ATOM 12608 CG GLN H 150 54.593 23.021 158.433 1.00 33.51 C +ATOM 12609 CD GLN H 150 54.554 22.587 159.901 1.00 33.19 C +ATOM 12610 OE1 GLN H 150 55.582 22.451 160.565 1.00 26.23 O +ATOM 12611 NE2 GLN H 150 53.355 22.349 160.401 1.00 43.42 N +ATOM 12612 N SER H 151 56.771 26.100 155.396 1.00 32.25 N +ATOM 12613 CA SER H 151 57.709 27.162 155.062 1.00 27.74 C +ATOM 12614 C SER H 151 56.905 28.408 154.690 1.00 25.75 C +ATOM 12615 O SER H 151 55.709 28.311 154.373 1.00 27.75 O +ATOM 12616 CB SER H 151 58.577 26.725 153.878 1.00 32.95 C +ATOM 12617 OG SER H 151 59.538 27.718 153.579 1.00 65.27 O +ATOM 12618 N LEU H 152 57.531 29.581 154.770 1.00 23.86 N +ATOM 12619 CA LEU H 152 56.834 30.810 154.386 1.00 15.05 C +ATOM 12620 C LEU H 152 57.282 31.270 152.996 1.00 12.72 C +ATOM 12621 O LEU H 152 58.480 31.284 152.672 1.00 8.50 O +ATOM 12622 CB LEU H 152 57.090 31.925 155.390 1.00 13.73 C +ATOM 12623 CG LEU H 152 56.589 33.310 154.980 1.00 8.50 C +ATOM 12624 CD1 LEU H 152 55.105 33.424 155.234 1.00 8.50 C +ATOM 12625 CD2 LEU H 152 57.346 34.364 155.756 1.00 8.50 C +ATOM 12626 N VAL H 153 56.305 31.609 152.166 1.00 11.03 N +ATOM 12627 CA VAL H 153 56.598 32.093 150.831 1.00 13.01 C +ATOM 12628 C VAL H 153 55.969 33.484 150.735 1.00 14.12 C +ATOM 12629 O VAL H 153 54.740 33.630 150.717 1.00 8.50 O +ATOM 12630 CB VAL H 153 56.013 31.186 149.744 1.00 16.60 C +ATOM 12631 CG1 VAL H 153 56.592 31.576 148.381 1.00 24.65 C +ATOM 12632 CG2 VAL H 153 56.300 29.739 150.050 1.00 15.15 C +ATOM 12633 N GLY H 154 56.833 34.494 150.734 1.00 12.50 N +ATOM 12634 CA GLY H 154 56.392 35.868 150.677 1.00 10.12 C +ATOM 12635 C GLY H 154 57.412 36.751 151.365 1.00 10.94 C +ATOM 12636 O GLY H 154 58.587 36.411 151.426 1.00 9.41 O +ATOM 12637 N ASP H 155 56.961 37.874 151.901 1.00 9.43 N +ATOM 12638 CA ASP H 155 57.846 38.808 152.568 1.00 8.50 C +ATOM 12639 C ASP H 155 57.554 38.849 154.043 1.00 8.50 C +ATOM 12640 O ASP H 155 56.416 38.668 154.467 1.00 10.38 O +ATOM 12641 CB ASP H 155 57.635 40.236 152.032 1.00 14.47 C +ATOM 12642 CG ASP H 155 58.106 40.423 150.616 1.00 8.50 C +ATOM 12643 OD1 ASP H 155 57.628 39.689 149.723 1.00 12.51 O +ATOM 12644 OD2 ASP H 155 58.929 41.339 150.404 1.00 8.50 O +ATOM 12645 N ILE H 156 58.577 39.143 154.825 1.00 8.50 N +ATOM 12646 CA ILE H 156 58.420 39.277 156.261 1.00 8.50 C +ATOM 12647 C ILE H 156 59.431 40.319 156.680 1.00 9.74 C +ATOM 12648 O ILE H 156 60.547 40.349 156.169 1.00 14.91 O +ATOM 12649 CB ILE H 156 58.658 37.965 157.012 1.00 8.50 C +ATOM 12650 CG1 ILE H 156 58.409 38.163 158.491 1.00 8.50 C +ATOM 12651 CG2 ILE H 156 60.070 37.488 156.807 1.00 16.81 C +ATOM 12652 CD1 ILE H 156 58.549 36.931 159.276 1.00 19.31 C +ATOM 12653 N GLY H 157 59.017 41.219 157.559 1.00 10.88 N +ATOM 12654 CA GLY H 157 59.904 42.268 157.998 1.00 9.15 C +ATOM 12655 C GLY H 157 59.382 42.930 159.245 1.00 11.28 C +ATOM 12656 O GLY H 157 58.359 42.517 159.809 1.00 8.50 O +ATOM 12657 N ASN H 158 60.100 43.973 159.659 1.00 16.65 N +ATOM 12658 CA ASN H 158 59.780 44.741 160.860 1.00 12.06 C +ATOM 12659 C ASN H 158 59.552 43.916 162.114 1.00 10.38 C +ATOM 12660 O ASN H 158 58.629 44.198 162.884 1.00 8.50 O +ATOM 12661 CB ASN H 158 58.580 45.661 160.623 1.00 15.74 C +ATOM 12662 CG ASN H 158 58.982 46.977 160.008 1.00 23.82 C +ATOM 12663 OD1 ASN H 158 58.455 47.367 158.968 1.00 26.85 O +ATOM 12664 ND2 ASN H 158 59.925 47.677 160.648 1.00 30.48 N +ATOM 12665 N VAL H 159 60.393 42.903 162.322 1.00 10.95 N +ATOM 12666 CA VAL H 159 60.251 42.068 163.503 1.00 11.93 C +ATOM 12667 C VAL H 159 61.001 42.727 164.653 1.00 10.43 C +ATOM 12668 O VAL H 159 62.129 43.184 164.492 1.00 12.32 O +ATOM 12669 CB VAL H 159 60.681 40.576 163.260 1.00 8.50 C +ATOM 12670 CG1 VAL H 159 61.316 40.394 161.916 1.00 8.50 C +ATOM 12671 CG2 VAL H 159 61.610 40.096 164.347 1.00 16.69 C +ATOM 12672 N ASN H 160 60.318 42.864 165.781 1.00 10.50 N +ATOM 12673 CA ASN H 160 60.881 43.466 166.991 1.00 14.07 C +ATOM 12674 C ASN H 160 60.340 42.654 168.169 1.00 15.84 C +ATOM 12675 O ASN H 160 59.269 42.043 168.059 1.00 16.81 O +ATOM 12676 CB ASN H 160 60.452 44.933 167.129 1.00 14.39 C +ATOM 12677 CG ASN H 160 60.986 45.801 166.018 1.00 13.73 C +ATOM 12678 OD1 ASN H 160 60.288 46.073 165.054 1.00 22.73 O +ATOM 12679 ND2 ASN H 160 62.229 46.248 166.150 1.00 14.23 N +ATOM 12680 N MET H 161 61.051 42.666 169.295 1.00 11.39 N +ATOM 12681 CA MET H 161 60.635 41.897 170.456 1.00 8.62 C +ATOM 12682 C MET H 161 61.060 42.582 171.732 1.00 10.86 C +ATOM 12683 O MET H 161 62.183 43.068 171.844 1.00 14.46 O +ATOM 12684 CB MET H 161 61.258 40.504 170.381 1.00 9.45 C +ATOM 12685 CG MET H 161 60.842 39.557 171.468 1.00 16.32 C +ATOM 12686 SD MET H 161 61.462 37.875 171.146 1.00 8.50 S +ATOM 12687 CE MET H 161 60.563 36.969 172.423 1.00 15.47 C +ATOM 12688 N TRP H 162 60.145 42.641 172.685 1.00 12.26 N +ATOM 12689 CA TRP H 162 60.403 43.252 173.982 1.00 13.31 C +ATOM 12690 C TRP H 162 60.289 42.148 175.026 1.00 15.53 C +ATOM 12691 O TRP H 162 59.613 41.137 174.792 1.00 17.78 O +ATOM 12692 CB TRP H 162 59.348 44.316 174.291 1.00 14.83 C +ATOM 12693 CG TRP H 162 59.359 45.511 173.363 1.00 23.67 C +ATOM 12694 CD1 TRP H 162 59.814 46.771 173.650 1.00 23.38 C +ATOM 12695 CD2 TRP H 162 58.824 45.575 172.039 1.00 16.98 C +ATOM 12696 NE1 TRP H 162 59.579 47.616 172.593 1.00 15.65 N +ATOM 12697 CE2 TRP H 162 58.972 46.908 171.592 1.00 17.16 C +ATOM 12698 CE3 TRP H 162 58.231 44.639 171.189 1.00 15.94 C +ATOM 12699 CZ2 TRP H 162 58.543 47.326 170.333 1.00 22.67 C +ATOM 12700 CZ3 TRP H 162 57.803 45.056 169.926 1.00 22.87 C +ATOM 12701 CH2 TRP H 162 57.961 46.386 169.512 1.00 21.69 C +ATOM 12702 N ASP H 163 60.935 42.335 176.175 1.00 15.79 N +ATOM 12703 CA ASP H 163 60.863 41.345 177.249 1.00 13.94 C +ATOM 12704 C ASP H 163 59.744 41.649 178.252 1.00 14.23 C +ATOM 12705 O ASP H 163 59.689 41.056 179.336 1.00 17.58 O +ATOM 12706 CB ASP H 163 62.222 41.181 177.957 1.00 14.38 C +ATOM 12707 CG ASP H 163 62.680 42.432 178.712 1.00 19.18 C +ATOM 12708 OD1 ASP H 163 61.845 43.254 179.152 1.00 20.40 O +ATOM 12709 OD2 ASP H 163 63.909 42.566 178.909 1.00 27.84 O +ATOM 12710 N PHE H 164 58.898 42.615 177.903 1.00 8.50 N +ATOM 12711 CA PHE H 164 57.771 43.012 178.733 1.00 8.50 C +ATOM 12712 C PHE H 164 56.552 43.191 177.854 1.00 8.50 C +ATOM 12713 O PHE H 164 56.658 43.151 176.633 1.00 15.05 O +ATOM 12714 CB PHE H 164 58.070 44.291 179.521 1.00 18.60 C +ATOM 12715 CG PHE H 164 58.343 45.500 178.669 1.00 15.32 C +ATOM 12716 CD1 PHE H 164 59.642 45.763 178.204 1.00 15.79 C +ATOM 12717 CD2 PHE H 164 57.316 46.386 178.356 1.00 8.50 C +ATOM 12718 CE1 PHE H 164 59.914 46.882 177.447 1.00 11.56 C +ATOM 12719 CE2 PHE H 164 57.572 47.506 177.603 1.00 8.50 C +ATOM 12720 CZ PHE H 164 58.877 47.759 177.144 1.00 17.38 C +ATOM 12721 N VAL H 165 55.397 43.395 178.463 1.00 9.86 N +ATOM 12722 CA VAL H 165 54.159 43.531 177.702 1.00 11.44 C +ATOM 12723 C VAL H 165 53.814 44.970 177.325 1.00 9.89 C +ATOM 12724 O VAL H 165 53.582 45.816 178.177 1.00 15.39 O +ATOM 12725 CB VAL H 165 52.951 42.894 178.460 1.00 15.02 C +ATOM 12726 CG1 VAL H 165 51.698 42.941 177.612 1.00 26.07 C +ATOM 12727 CG2 VAL H 165 53.255 41.471 178.856 1.00 8.50 C +ATOM 12728 N LEU H 166 53.768 45.230 176.030 1.00 12.45 N +ATOM 12729 CA LEU H 166 53.428 46.554 175.520 1.00 12.46 C +ATOM 12730 C LEU H 166 51.980 46.900 175.859 1.00 9.34 C +ATOM 12731 O LEU H 166 51.090 46.029 175.886 1.00 8.50 O +ATOM 12732 CB LEU H 166 53.622 46.601 173.996 1.00 13.30 C +ATOM 12733 CG LEU H 166 54.893 47.255 173.458 1.00 12.74 C +ATOM 12734 CD1 LEU H 166 56.114 46.706 174.138 1.00 8.50 C +ATOM 12735 CD2 LEU H 166 54.967 47.017 171.972 1.00 20.17 C +ATOM 12736 N SER H 167 51.756 48.177 176.134 1.00 9.07 N +ATOM 12737 CA SER H 167 50.415 48.634 176.457 1.00 15.32 C +ATOM 12738 C SER H 167 49.687 48.939 175.159 1.00 15.41 C +ATOM 12739 O SER H 167 50.312 49.028 174.099 1.00 17.71 O +ATOM 12740 CB SER H 167 50.467 49.891 177.343 1.00 23.39 C +ATOM 12741 OG SER H 167 50.902 51.040 176.635 1.00 34.27 O +ATOM 12742 N PRO H 168 48.358 49.110 175.222 1.00 11.66 N +ATOM 12743 CA PRO H 168 47.570 49.413 174.033 1.00 10.62 C +ATOM 12744 C PRO H 168 48.080 50.656 173.304 1.00 14.86 C +ATOM 12745 O PRO H 168 48.133 50.691 172.076 1.00 22.53 O +ATOM 12746 CB PRO H 168 46.192 49.647 174.617 1.00 11.21 C +ATOM 12747 CG PRO H 168 46.151 48.689 175.729 1.00 8.50 C +ATOM 12748 CD PRO H 168 47.478 48.900 176.378 1.00 9.83 C +ATOM 12749 N ASP H 169 48.491 51.660 174.063 1.00 14.05 N +ATOM 12750 CA ASP H 169 48.984 52.889 173.468 1.00 17.91 C +ATOM 12751 C ASP H 169 50.318 52.657 172.759 1.00 16.47 C +ATOM 12752 O ASP H 169 50.542 53.162 171.654 1.00 20.93 O +ATOM 12753 CB ASP H 169 49.117 53.989 174.533 1.00 27.94 C +ATOM 12754 CG ASP H 169 47.787 54.339 175.192 1.00 35.50 C +ATOM 12755 OD1 ASP H 169 46.882 54.871 174.500 1.00 38.54 O +ATOM 12756 OD2 ASP H 169 47.655 54.082 176.410 1.00 40.74 O +ATOM 12757 N GLU H 170 51.192 51.878 173.380 1.00 8.50 N +ATOM 12758 CA GLU H 170 52.479 51.602 172.785 1.00 8.50 C +ATOM 12759 C GLU H 170 52.242 50.754 171.531 1.00 11.48 C +ATOM 12760 O GLU H 170 52.677 51.112 170.446 1.00 14.22 O +ATOM 12761 CB GLU H 170 53.380 50.879 173.782 1.00 13.92 C +ATOM 12762 CG GLU H 170 53.545 51.610 175.115 1.00 26.19 C +ATOM 12763 CD GLU H 170 54.478 50.897 176.092 1.00 35.09 C +ATOM 12764 OE1 GLU H 170 55.694 50.820 175.802 1.00 43.14 O +ATOM 12765 OE2 GLU H 170 53.999 50.432 177.151 1.00 28.10 O +ATOM 12766 N ILE H 171 51.478 49.678 171.662 1.00 10.95 N +ATOM 12767 CA ILE H 171 51.186 48.808 170.531 1.00 10.57 C +ATOM 12768 C ILE H 171 50.608 49.627 169.400 1.00 14.66 C +ATOM 12769 O ILE H 171 50.814 49.316 168.217 1.00 13.66 O +ATOM 12770 CB ILE H 171 50.197 47.707 170.916 1.00 9.77 C +ATOM 12771 CG1 ILE H 171 50.910 46.718 171.824 1.00 14.33 C +ATOM 12772 CG2 ILE H 171 49.646 47.000 169.687 1.00 8.50 C +ATOM 12773 CD1 ILE H 171 50.055 45.566 172.253 1.00 26.18 C +ATOM 12774 N ASN H 172 49.922 50.706 169.762 1.00 16.03 N +ATOM 12775 CA ASN H 172 49.344 51.560 168.758 1.00 18.78 C +ATOM 12776 C ASN H 172 50.404 52.374 168.046 1.00 14.23 C +ATOM 12777 O ASN H 172 50.425 52.392 166.826 1.00 20.19 O +ATOM 12778 CB ASN H 172 48.297 52.476 169.336 1.00 29.78 C +ATOM 12779 CG ASN H 172 47.585 53.255 168.264 1.00 40.84 C +ATOM 12780 OD1 ASN H 172 47.854 54.442 168.058 1.00 48.07 O +ATOM 12781 ND2 ASN H 172 46.703 52.581 167.535 1.00 42.01 N +ATOM 12782 N THR H 173 51.308 53.014 168.776 1.00 8.82 N +ATOM 12783 CA THR H 173 52.343 53.789 168.098 1.00 10.68 C +ATOM 12784 C THR H 173 53.209 52.878 167.243 1.00 9.57 C +ATOM 12785 O THR H 173 53.566 53.251 166.135 1.00 15.05 O +ATOM 12786 CB THR H 173 53.247 54.642 169.047 1.00 19.26 C +ATOM 12787 OG1 THR H 173 54.396 53.887 169.454 1.00 13.30 O +ATOM 12788 CG2 THR H 173 52.459 55.137 170.280 1.00 16.98 C +ATOM 12789 N ILE H 174 53.519 51.674 167.720 1.00 9.42 N +ATOM 12790 CA ILE H 174 54.320 50.754 166.917 1.00 9.48 C +ATOM 12791 C ILE H 174 53.630 50.581 165.570 1.00 9.31 C +ATOM 12792 O ILE H 174 54.261 50.696 164.514 1.00 9.06 O +ATOM 12793 CB ILE H 174 54.479 49.367 167.567 1.00 8.50 C +ATOM 12794 CG1 ILE H 174 55.614 49.385 168.584 1.00 14.48 C +ATOM 12795 CG2 ILE H 174 54.868 48.343 166.536 1.00 13.78 C +ATOM 12796 CD1 ILE H 174 55.247 50.001 169.900 1.00 24.10 C +ATOM 12797 N TYR H 175 52.324 50.350 165.607 1.00 8.55 N +ATOM 12798 CA TYR H 175 51.563 50.168 164.378 1.00 10.07 C +ATOM 12799 C TYR H 175 51.592 51.382 163.465 1.00 18.28 C +ATOM 12800 O TYR H 175 51.870 51.266 162.271 1.00 23.98 O +ATOM 12801 CB TYR H 175 50.111 49.837 164.684 1.00 8.54 C +ATOM 12802 CG TYR H 175 49.246 49.726 163.444 1.00 10.02 C +ATOM 12803 CD1 TYR H 175 49.626 48.921 162.365 1.00 14.52 C +ATOM 12804 CD2 TYR H 175 48.048 50.423 163.352 1.00 17.46 C +ATOM 12805 CE1 TYR H 175 48.835 48.815 161.230 1.00 19.09 C +ATOM 12806 CE2 TYR H 175 47.242 50.327 162.215 1.00 25.80 C +ATOM 12807 CZ TYR H 175 47.643 49.522 161.160 1.00 29.00 C +ATOM 12808 OH TYR H 175 46.851 49.419 160.034 1.00 43.82 O +ATOM 12809 N LEU H 176 51.263 52.536 164.038 1.00 22.88 N +ATOM 12810 CA LEU H 176 51.207 53.806 163.323 1.00 18.95 C +ATOM 12811 C LEU H 176 52.548 54.360 162.889 1.00 24.26 C +ATOM 12812 O LEU H 176 52.593 55.367 162.192 1.00 30.40 O +ATOM 12813 CB LEU H 176 50.497 54.846 164.169 1.00 13.45 C +ATOM 12814 CG LEU H 176 49.079 55.196 163.768 1.00 16.23 C +ATOM 12815 CD1 LEU H 176 48.473 54.101 162.907 1.00 28.02 C +ATOM 12816 CD2 LEU H 176 48.268 55.436 165.026 1.00 24.51 C +ATOM 12817 N GLY H 177 53.637 53.725 163.304 1.00 26.56 N +ATOM 12818 CA GLY H 177 54.953 54.194 162.916 1.00 32.54 C +ATOM 12819 C GLY H 177 55.443 55.308 163.808 1.00 37.30 C +ATOM 12820 O GLY H 177 55.707 56.419 163.351 1.00 47.41 O +ATOM 12821 N GLY H 178 55.489 55.034 165.102 1.00 40.74 N +ATOM 12822 CA GLY H 178 55.978 56.020 166.044 1.00 38.95 C +ATOM 12823 C GLY H 178 57.372 55.567 166.437 1.00 41.12 C +ATOM 12824 O GLY H 178 57.898 54.600 165.857 1.00 42.26 O +ATOM 12825 N PRO H 179 58.039 56.295 167.350 1.00 40.08 N +ATOM 12826 CA PRO H 179 59.390 55.904 167.780 1.00 37.64 C +ATOM 12827 C PRO H 179 59.306 55.033 169.037 1.00 34.55 C +ATOM 12828 O PRO H 179 58.499 55.295 169.940 1.00 35.05 O +ATOM 12829 CB PRO H 179 60.064 57.257 168.050 1.00 44.88 C +ATOM 12830 CG PRO H 179 58.932 58.074 168.612 1.00 39.92 C +ATOM 12831 CD PRO H 179 57.722 57.680 167.767 1.00 41.14 C +ATOM 12832 N PHE H 180 60.140 54.003 169.093 1.00 31.33 N +ATOM 12833 CA PHE H 180 60.154 53.088 170.232 1.00 29.03 C +ATOM 12834 C PHE H 180 61.503 52.372 170.262 1.00 31.19 C +ATOM 12835 O PHE H 180 62.266 52.428 169.279 1.00 29.78 O +ATOM 12836 CB PHE H 180 59.032 52.058 170.086 1.00 29.55 C +ATOM 12837 CG PHE H 180 59.010 51.378 168.734 1.00 34.18 C +ATOM 12838 CD1 PHE H 180 58.303 51.939 167.670 1.00 38.98 C +ATOM 12839 CD2 PHE H 180 59.731 50.206 168.513 1.00 33.55 C +ATOM 12840 CE1 PHE H 180 58.318 51.348 166.412 1.00 36.64 C +ATOM 12841 CE2 PHE H 180 59.751 49.611 167.255 1.00 35.58 C +ATOM 12842 CZ PHE H 180 59.043 50.185 166.205 1.00 39.31 C +ATOM 12843 N SER H 181 61.783 51.685 171.372 1.00 30.36 N +ATOM 12844 CA SER H 181 63.040 50.956 171.528 1.00 31.00 C +ATOM 12845 C SER H 181 62.851 49.549 172.080 1.00 30.32 C +ATOM 12846 O SER H 181 62.580 49.369 173.268 1.00 39.59 O +ATOM 12847 CB SER H 181 64.017 51.729 172.427 1.00 35.20 C +ATOM 12848 OG SER H 181 65.151 52.171 171.697 1.00 55.39 O +ATOM 12849 N PRO H 182 62.946 48.530 171.209 1.00 26.43 N +ATOM 12850 CA PRO H 182 62.799 47.119 171.599 1.00 22.45 C +ATOM 12851 C PRO H 182 63.996 46.794 172.475 1.00 23.87 C +ATOM 12852 O PRO H 182 64.999 47.516 172.446 1.00 28.03 O +ATOM 12853 CB PRO H 182 62.939 46.379 170.268 1.00 24.68 C +ATOM 12854 CG PRO H 182 62.531 47.397 169.248 1.00 31.33 C +ATOM 12855 CD PRO H 182 63.190 48.648 169.759 1.00 28.20 C +ATOM 12856 N ASN H 183 63.921 45.714 173.241 1.00 24.24 N +ATOM 12857 CA ASN H 183 65.058 45.360 174.094 1.00 18.57 C +ATOM 12858 C ASN H 183 65.451 43.892 174.051 1.00 15.57 C +ATOM 12859 O ASN H 183 66.045 43.382 174.989 1.00 26.89 O +ATOM 12860 CB ASN H 183 64.848 45.835 175.541 1.00 19.31 C +ATOM 12861 CG ASN H 183 63.741 45.091 176.254 1.00 17.18 C +ATOM 12862 OD1 ASN H 183 62.962 44.342 175.646 1.00 15.93 O +ATOM 12863 ND2 ASN H 183 63.655 45.305 177.560 1.00 21.67 N +ATOM 12864 N VAL H 184 65.091 43.216 172.967 1.00 12.69 N +ATOM 12865 CA VAL H 184 65.429 41.811 172.765 1.00 11.60 C +ATOM 12866 C VAL H 184 65.810 41.706 171.283 1.00 14.33 C +ATOM 12867 O VAL H 184 66.969 41.454 170.945 1.00 21.72 O +ATOM 12868 CB VAL H 184 64.243 40.847 173.077 1.00 8.50 C +ATOM 12869 CG1 VAL H 184 64.649 39.435 172.781 1.00 11.33 C +ATOM 12870 CG2 VAL H 184 63.816 40.945 174.517 1.00 8.50 C +ATOM 12871 N LEU H 185 64.843 41.934 170.402 1.00 10.87 N +ATOM 12872 CA LEU H 185 65.090 41.890 168.967 1.00 10.81 C +ATOM 12873 C LEU H 185 64.800 43.304 168.482 1.00 18.05 C +ATOM 12874 O LEU H 185 63.755 43.878 168.818 1.00 19.06 O +ATOM 12875 CB LEU H 185 64.148 40.899 168.290 1.00 8.50 C +ATOM 12876 CG LEU H 185 64.808 39.659 167.697 1.00 15.63 C +ATOM 12877 CD1 LEU H 185 65.726 39.028 168.701 1.00 16.68 C +ATOM 12878 CD2 LEU H 185 63.749 38.661 167.261 1.00 24.76 C +ATOM 12879 N ASN H 186 65.733 43.883 167.733 1.00 19.38 N +ATOM 12880 CA ASN H 186 65.574 45.245 167.237 1.00 14.17 C +ATOM 12881 C ASN H 186 65.827 45.267 165.733 1.00 18.00 C +ATOM 12882 O ASN H 186 66.955 45.028 165.285 1.00 22.83 O +ATOM 12883 CB ASN H 186 66.581 46.159 167.947 1.00 21.02 C +ATOM 12884 CG ASN H 186 66.380 47.634 167.624 1.00 21.12 C +ATOM 12885 OD1 ASN H 186 65.869 47.986 166.570 1.00 26.03 O +ATOM 12886 ND2 ASN H 186 66.775 48.501 168.541 1.00 22.63 N +ATOM 12887 N TRP H 187 64.794 45.589 164.958 1.00 13.05 N +ATOM 12888 CA TRP H 187 64.915 45.639 163.507 1.00 9.96 C +ATOM 12889 C TRP H 187 65.910 46.689 163.023 1.00 12.74 C +ATOM 12890 O TRP H 187 66.395 46.617 161.891 1.00 18.78 O +ATOM 12891 CB TRP H 187 63.545 45.887 162.883 1.00 14.50 C +ATOM 12892 CG TRP H 187 63.456 45.553 161.406 1.00 13.22 C +ATOM 12893 CD1 TRP H 187 63.246 46.426 160.390 1.00 8.50 C +ATOM 12894 CD2 TRP H 187 63.556 44.254 160.805 1.00 14.11 C +ATOM 12895 NE1 TRP H 187 63.208 45.764 159.202 1.00 13.73 N +ATOM 12896 CE2 TRP H 187 63.393 44.426 159.425 1.00 15.13 C +ATOM 12897 CE3 TRP H 187 63.768 42.962 161.303 1.00 17.65 C +ATOM 12898 CZ2 TRP H 187 63.431 43.356 158.527 1.00 15.40 C +ATOM 12899 CZ3 TRP H 187 63.806 41.902 160.410 1.00 16.63 C +ATOM 12900 CH2 TRP H 187 63.636 42.109 159.037 1.00 11.37 C +ATOM 12901 N ARG H 188 66.199 47.675 163.865 1.00 12.62 N +ATOM 12902 CA ARG H 188 67.152 48.725 163.505 1.00 21.19 C +ATOM 12903 C ARG H 188 68.601 48.322 163.790 1.00 27.16 C +ATOM 12904 O ARG H 188 69.541 48.933 163.266 1.00 34.16 O +ATOM 12905 CB ARG H 188 66.826 50.072 164.178 1.00 39.12 C +ATOM 12906 CG ARG H 188 65.911 51.014 163.372 1.00 40.27 C +ATOM 12907 CD ARG H 188 65.923 52.435 163.940 1.00 36.90 C +ATOM 12908 NE ARG H 188 65.345 52.510 165.283 1.00 49.99 N +ATOM 12909 CZ ARG H 188 66.045 52.631 166.413 1.00 61.01 C +ATOM 12910 NH1 ARG H 188 67.375 52.689 166.393 1.00 66.84 N +ATOM 12911 NH2 ARG H 188 65.409 52.712 167.575 1.00 62.08 N +ATOM 12912 N ALA H 189 68.777 47.282 164.597 1.00 24.89 N +ATOM 12913 CA ALA H 189 70.102 46.779 164.937 1.00 23.53 C +ATOM 12914 C ALA H 189 69.966 45.265 164.952 1.00 24.26 C +ATOM 12915 O ALA H 189 70.222 44.610 165.981 1.00 29.49 O +ATOM 12916 CB ALA H 189 70.520 47.297 166.325 1.00 23.60 C +ATOM 12917 N LEU H 190 69.522 44.716 163.824 1.00 17.93 N +ATOM 12918 CA LEU H 190 69.306 43.275 163.714 1.00 23.24 C +ATOM 12919 C LEU H 190 70.619 42.537 163.454 1.00 27.08 C +ATOM 12920 O LEU H 190 71.504 43.043 162.749 1.00 28.99 O +ATOM 12921 CB LEU H 190 68.305 42.970 162.601 1.00 15.79 C +ATOM 12922 CG LEU H 190 67.657 41.596 162.632 1.00 8.64 C +ATOM 12923 CD1 LEU H 190 66.557 41.616 163.663 1.00 8.50 C +ATOM 12924 CD2 LEU H 190 67.092 41.235 161.275 1.00 9.14 C +ATOM 12925 N LYS H 191 70.777 41.384 164.097 1.00 29.83 N +ATOM 12926 CA LYS H 191 71.969 40.560 163.934 1.00 28.51 C +ATOM 12927 C LYS H 191 71.400 39.237 163.454 1.00 25.77 C +ATOM 12928 O LYS H 191 70.812 38.485 164.220 1.00 24.82 O +ATOM 12929 CB LYS H 191 72.695 40.407 165.274 1.00 38.32 C +ATOM 12930 CG LYS H 191 74.195 40.150 165.150 1.00 59.62 C +ATOM 12931 CD LYS H 191 74.924 40.491 166.451 1.00 77.42 C +ATOM 12932 CE LYS H 191 76.433 40.303 166.317 1.00 90.51 C +ATOM 12933 NZ LYS H 191 77.176 40.796 167.524 1.00 99.34 N +ATOM 12934 N TYR H 192 71.534 38.973 162.166 1.00 26.79 N +ATOM 12935 CA TYR H 192 70.967 37.770 161.592 1.00 25.38 C +ATOM 12936 C TYR H 192 71.945 37.011 160.707 1.00 30.63 C +ATOM 12937 O TYR H 192 73.069 37.451 160.464 1.00 36.30 O +ATOM 12938 CB TYR H 192 69.733 38.161 160.771 1.00 26.94 C +ATOM 12939 CG TYR H 192 70.049 39.079 159.600 1.00 19.77 C +ATOM 12940 CD1 TYR H 192 70.346 40.424 159.807 1.00 14.35 C +ATOM 12941 CD2 TYR H 192 70.115 38.577 158.291 1.00 16.45 C +ATOM 12942 CE1 TYR H 192 70.715 41.245 158.738 1.00 26.06 C +ATOM 12943 CE2 TYR H 192 70.479 39.391 157.209 1.00 18.43 C +ATOM 12944 CZ TYR H 192 70.781 40.722 157.436 1.00 24.90 C +ATOM 12945 OH TYR H 192 71.152 41.520 156.370 1.00 25.92 O +ATOM 12946 N GLU H 193 71.464 35.898 160.172 1.00 35.12 N +ATOM 12947 CA GLU H 193 72.236 35.038 159.295 1.00 37.64 C +ATOM 12948 C GLU H 193 71.228 34.420 158.315 1.00 35.90 C +ATOM 12949 O GLU H 193 70.230 33.807 158.716 1.00 34.52 O +ATOM 12950 CB GLU H 193 72.926 33.958 160.132 1.00 54.96 C +ATOM 12951 CG GLU H 193 74.063 33.217 159.446 1.00 71.46 C +ATOM 12952 CD GLU H 193 74.707 32.182 160.367 1.00 84.85 C +ATOM 12953 OE1 GLU H 193 74.195 31.035 160.432 1.00 90.08 O +ATOM 12954 OE2 GLU H 193 75.715 32.522 161.035 1.00 89.08 O +ATOM 12955 N VAL H 194 71.461 34.651 157.032 1.00 34.81 N +ATOM 12956 CA VAL H 194 70.591 34.151 155.980 1.00 33.17 C +ATOM 12957 C VAL H 194 71.069 32.786 155.511 1.00 34.65 C +ATOM 12958 O VAL H 194 72.268 32.494 155.543 1.00 36.12 O +ATOM 12959 CB VAL H 194 70.577 35.128 154.791 1.00 29.61 C +ATOM 12960 CG1 VAL H 194 69.806 34.552 153.626 1.00 32.25 C +ATOM 12961 CG2 VAL H 194 69.956 36.442 155.222 1.00 41.48 C +ATOM 12962 N GLN H 195 70.126 31.955 155.079 1.00 34.62 N +ATOM 12963 CA GLN H 195 70.454 30.627 154.601 1.00 33.02 C +ATOM 12964 C GLN H 195 69.480 30.227 153.513 1.00 28.98 C +ATOM 12965 O GLN H 195 68.269 30.204 153.738 1.00 30.16 O +ATOM 12966 CB GLN H 195 70.361 29.621 155.745 1.00 47.86 C +ATOM 12967 CG GLN H 195 71.314 28.440 155.615 1.00 65.35 C +ATOM 12968 CD GLN H 195 72.770 28.862 155.739 1.00 73.83 C +ATOM 12969 OE1 GLN H 195 73.551 28.724 154.797 1.00 82.58 O +ATOM 12970 NE2 GLN H 195 73.138 29.386 156.904 1.00 74.44 N +ATOM 12971 N GLY H 196 70.002 29.945 152.325 1.00 25.68 N +ATOM 12972 CA GLY H 196 69.141 29.523 151.236 1.00 26.44 C +ATOM 12973 C GLY H 196 68.693 30.620 150.294 1.00 28.67 C +ATOM 12974 O GLY H 196 69.364 31.641 150.126 1.00 33.21 O +ATOM 12975 N GLU H 197 67.533 30.400 149.689 1.00 26.93 N +ATOM 12976 CA GLU H 197 66.960 31.327 148.725 1.00 21.10 C +ATOM 12977 C GLU H 197 66.166 32.468 149.374 1.00 21.75 C +ATOM 12978 O GLU H 197 64.930 32.505 149.289 1.00 30.14 O +ATOM 12979 CB GLU H 197 66.057 30.536 147.772 1.00 24.84 C +ATOM 12980 CG GLU H 197 65.661 31.269 146.512 1.00 35.53 C +ATOM 12981 CD GLU H 197 66.637 31.060 145.372 1.00 39.76 C +ATOM 12982 OE1 GLU H 197 67.823 30.711 145.615 1.00 33.33 O +ATOM 12983 OE2 GLU H 197 66.191 31.244 144.219 1.00 44.79 O +ATOM 12984 N VAL H 198 66.856 33.373 150.057 1.00 13.09 N +ATOM 12985 CA VAL H 198 66.185 34.503 150.683 1.00 9.18 C +ATOM 12986 C VAL H 198 66.957 35.764 150.351 1.00 14.67 C +ATOM 12987 O VAL H 198 68.194 35.781 150.422 1.00 21.05 O +ATOM 12988 CB VAL H 198 65.982 34.302 152.216 1.00 8.50 C +ATOM 12989 CG1 VAL H 198 66.800 33.160 152.731 1.00 8.50 C +ATOM 12990 CG2 VAL H 198 66.301 35.554 152.990 1.00 15.13 C +ATOM 12991 N PHE H 199 66.230 36.793 149.916 1.00 11.47 N +ATOM 12992 CA PHE H 199 66.831 38.069 149.527 1.00 13.71 C +ATOM 12993 C PHE H 199 66.327 39.226 150.384 1.00 16.24 C +ATOM 12994 O PHE H 199 65.282 39.125 151.027 1.00 20.88 O +ATOM 12995 CB PHE H 199 66.498 38.388 148.073 1.00 8.93 C +ATOM 12996 CG PHE H 199 66.724 37.252 147.125 1.00 15.97 C +ATOM 12997 CD1 PHE H 199 65.732 36.300 146.923 1.00 21.47 C +ATOM 12998 CD2 PHE H 199 67.930 37.117 146.437 1.00 20.37 C +ATOM 12999 CE1 PHE H 199 65.937 35.223 146.052 1.00 19.76 C +ATOM 13000 CE2 PHE H 199 68.144 36.050 145.570 1.00 13.54 C +ATOM 13001 CZ PHE H 199 67.148 35.103 145.378 1.00 18.26 C +ATOM 13002 N THR H 200 67.056 40.335 150.358 1.00 12.70 N +ATOM 13003 CA THR H 200 66.683 41.518 151.115 1.00 10.32 C +ATOM 13004 C THR H 200 66.265 42.565 150.087 1.00 11.28 C +ATOM 13005 O THR H 200 67.069 42.996 149.268 1.00 23.05 O +ATOM 13006 CB THR H 200 67.885 42.048 151.936 1.00 9.71 C +ATOM 13007 OG1 THR H 200 68.374 41.019 152.799 1.00 29.62 O +ATOM 13008 CG2 THR H 200 67.483 43.216 152.780 1.00 10.04 C +ATOM 13009 N LYS H 201 64.995 42.932 150.097 1.00 12.30 N +ATOM 13010 CA LYS H 201 64.465 43.931 149.177 1.00 9.30 C +ATOM 13011 C LYS H 201 63.664 45.011 149.942 1.00 8.97 C +ATOM 13012 O LYS H 201 63.405 44.872 151.128 1.00 11.11 O +ATOM 13013 CB LYS H 201 63.581 43.248 148.125 1.00 11.39 C +ATOM 13014 CG LYS H 201 64.317 42.332 147.142 1.00 8.50 C +ATOM 13015 CD LYS H 201 65.503 43.020 146.482 1.00 15.52 C +ATOM 13016 CE LYS H 201 65.837 42.403 145.130 1.00 20.06 C +ATOM 13017 NZ LYS H 201 64.758 42.680 144.120 1.00 32.17 N +ATOM 13018 N PRO H 202 63.318 46.126 149.286 1.00 8.50 N +ATOM 13019 CA PRO H 202 62.559 47.203 149.914 1.00 8.50 C +ATOM 13020 C PRO H 202 61.171 46.713 150.278 1.00 10.32 C +ATOM 13021 O PRO H 202 60.527 46.069 149.474 1.00 14.50 O +ATOM 13022 CB PRO H 202 62.466 48.233 148.800 1.00 10.92 C +ATOM 13023 CG PRO H 202 63.687 47.981 147.986 1.00 10.78 C +ATOM 13024 CD PRO H 202 63.700 46.502 147.916 1.00 14.88 C +ATOM 13025 N GLN H 203 60.683 47.067 151.461 1.00 10.63 N +ATOM 13026 CA GLN H 203 59.362 46.622 151.898 1.00 8.50 C +ATOM 13027 C GLN H 203 58.216 47.155 151.067 1.00 8.50 C +ATOM 13028 O GLN H 203 58.220 48.310 150.674 1.00 11.25 O +ATOM 13029 CB GLN H 203 59.134 46.991 153.351 1.00 15.27 C +ATOM 13030 CG GLN H 203 59.249 48.453 153.654 1.00 8.50 C +ATOM 13031 CD GLN H 203 58.944 48.732 155.097 1.00 19.61 C +ATOM 13032 OE1 GLN H 203 58.151 49.598 155.409 1.00 38.26 O +ATOM 13033 NE2 GLN H 203 59.571 47.987 155.994 1.00 27.52 N +ATOM 13034 N LEU H 204 57.213 46.316 150.859 1.00 8.50 N +ATOM 13035 CA LEU H 204 56.040 46.676 150.073 1.00 9.03 C +ATOM 13036 C LEU H 204 54.973 47.401 150.870 1.00 11.26 C +ATOM 13037 O LEU H 204 54.154 48.139 150.306 1.00 12.31 O +ATOM 13038 CB LEU H 204 55.428 45.437 149.417 1.00 8.50 C +ATOM 13039 CG LEU H 204 56.440 44.635 148.619 1.00 8.50 C +ATOM 13040 CD1 LEU H 204 56.911 43.525 149.519 1.00 22.88 C +ATOM 13041 CD2 LEU H 204 55.843 44.090 147.349 1.00 8.50 C +ATOM 13042 N TRP H 205 54.904 47.097 152.162 1.00 15.01 N +ATOM 13043 CA TRP H 205 53.949 47.766 153.036 1.00 18.61 C +ATOM 13044 C TRP H 205 54.578 49.111 153.376 1.00 27.16 C +ATOM 13045 O TRP H 205 55.809 49.250 153.374 1.00 33.13 O +ATOM 13046 CB TRP H 205 53.698 46.972 154.313 1.00 17.05 C +ATOM 13047 CG TRP H 205 54.935 46.397 154.933 1.00 18.73 C +ATOM 13048 CD1 TRP H 205 55.783 47.009 155.816 1.00 8.50 C +ATOM 13049 CD2 TRP H 205 55.457 45.081 154.717 1.00 20.75 C +ATOM 13050 NE1 TRP H 205 56.791 46.159 156.161 1.00 12.42 N +ATOM 13051 CE2 TRP H 205 56.617 44.965 155.504 1.00 21.54 C +ATOM 13052 CE3 TRP H 205 55.057 43.990 153.929 1.00 9.63 C +ATOM 13053 CZ2 TRP H 205 57.384 43.793 155.528 1.00 22.58 C +ATOM 13054 CZ3 TRP H 205 55.818 42.840 153.954 1.00 8.50 C +ATOM 13055 CH2 TRP H 205 56.964 42.748 154.747 1.00 12.67 C +ATOM 13056 N PRO H 206 53.741 50.132 153.597 1.00 30.36 N +ATOM 13057 CA PRO H 206 54.222 51.471 153.926 1.00 29.73 C +ATOM 13058 C PRO H 206 54.650 51.616 155.391 1.00 35.95 C +ATOM 13059 O PRO H 206 55.561 52.433 155.642 1.00 41.50 O +ATOM 13060 CB PRO H 206 53.016 52.335 153.579 1.00 25.73 C +ATOM 13061 CG PRO H 206 51.871 51.461 153.977 1.00 26.06 C +ATOM 13062 CD PRO H 206 52.276 50.123 153.424 1.00 30.92 C +ATOM 13063 OXT PRO H 206 54.078 50.922 156.268 1.00 36.98 O +TER 13064 PRO H 206 +ATOM 13065 N GLN I 1 59.233 59.258 117.214 1.00 60.99 N +ATOM 13066 CA GLN I 1 59.597 60.418 118.074 1.00 50.80 C +ATOM 13067 C GLN I 1 58.345 61.264 118.195 1.00 50.52 C +ATOM 13068 O GLN I 1 58.320 62.408 117.751 1.00 59.65 O +ATOM 13069 CB GLN I 1 60.674 61.272 117.397 1.00 41.25 C +ATOM 13070 CG GLN I 1 61.756 60.499 116.692 1.00 37.03 C +ATOM 13071 CD GLN I 1 62.651 59.815 117.674 1.00 64.82 C +ATOM 13072 OE1 GLN I 1 62.586 60.109 118.867 1.00 83.12 O +ATOM 13073 NE2 GLN I 1 63.491 58.895 117.199 1.00 65.64 N +ATOM 13074 N THR I 2 57.295 60.694 118.760 1.00 40.96 N +ATOM 13075 CA THR I 2 56.048 61.421 118.905 1.00 35.23 C +ATOM 13076 C THR I 2 55.714 61.529 120.379 1.00 33.71 C +ATOM 13077 O THR I 2 55.944 60.585 121.133 1.00 39.00 O +ATOM 13078 CB THR I 2 54.915 60.684 118.195 1.00 27.17 C +ATOM 13079 OG1 THR I 2 55.350 60.321 116.885 1.00 36.68 O +ATOM 13080 CG2 THR I 2 53.680 61.567 118.091 1.00 39.65 C +ATOM 13081 N ASP I 3 55.229 62.689 120.805 1.00 28.78 N +ATOM 13082 CA ASP I 3 54.855 62.858 122.198 1.00 22.66 C +ATOM 13083 C ASP I 3 53.438 62.344 122.306 1.00 24.76 C +ATOM 13084 O ASP I 3 52.478 63.043 121.942 1.00 26.39 O +ATOM 13085 CB ASP I 3 54.913 64.324 122.613 1.00 33.19 C +ATOM 13086 CG ASP I 3 54.945 64.504 124.123 1.00 31.14 C +ATOM 13087 OD1 ASP I 3 54.652 63.525 124.839 1.00 22.90 O +ATOM 13088 OD2 ASP I 3 55.278 65.619 124.588 1.00 37.53 O +ATOM 13089 N MET I 4 53.321 61.104 122.766 1.00 20.75 N +ATOM 13090 CA MET I 4 52.032 60.454 122.907 1.00 16.83 C +ATOM 13091 C MET I 4 51.272 60.852 124.165 1.00 17.02 C +ATOM 13092 O MET I 4 50.258 60.222 124.499 1.00 16.35 O +ATOM 13093 CB MET I 4 52.205 58.942 122.839 1.00 13.86 C +ATOM 13094 CG MET I 4 52.529 58.436 121.462 1.00 8.50 C +ATOM 13095 SD MET I 4 51.230 58.963 120.314 1.00 26.43 S +ATOM 13096 CE MET I 4 49.977 57.699 120.593 1.00 18.25 C +ATOM 13097 N SER I 5 51.731 61.918 124.827 1.00 11.89 N +ATOM 13098 CA SER I 5 51.101 62.409 126.044 1.00 11.89 C +ATOM 13099 C SER I 5 49.622 62.699 125.899 1.00 14.53 C +ATOM 13100 O SER I 5 49.202 63.328 124.939 1.00 20.25 O +ATOM 13101 CB SER I 5 51.782 63.669 126.537 1.00 13.95 C +ATOM 13102 OG SER I 5 53.032 63.365 127.110 1.00 28.57 O +ATOM 13103 N ARG I 6 48.849 62.236 126.878 1.00 14.34 N +ATOM 13104 CA ARG I 6 47.415 62.448 126.922 1.00 12.42 C +ATOM 13105 C ARG I 6 46.663 61.694 125.822 1.00 15.10 C +ATOM 13106 O ARG I 6 45.460 61.910 125.610 1.00 19.04 O +ATOM 13107 CB ARG I 6 47.123 63.959 126.853 1.00 18.35 C +ATOM 13108 CG ARG I 6 45.892 64.421 127.650 1.00 41.87 C +ATOM 13109 CD ARG I 6 46.219 65.339 128.853 1.00 37.81 C +ATOM 13110 NE ARG I 6 47.326 64.880 129.718 1.00 36.83 N +ATOM 13111 CZ ARG I 6 47.185 64.274 130.903 1.00 36.15 C +ATOM 13112 NH1 ARG I 6 45.967 64.008 131.398 1.00 20.83 N +ATOM 13113 NH2 ARG I 6 48.273 64.009 131.633 1.00 16.98 N +ATOM 13114 N LYS I 7 47.356 60.777 125.153 1.00 15.11 N +ATOM 13115 CA LYS I 7 46.753 59.985 124.086 1.00 12.41 C +ATOM 13116 C LYS I 7 46.773 58.482 124.368 1.00 12.73 C +ATOM 13117 O LYS I 7 47.498 58.001 125.256 1.00 10.08 O +ATOM 13118 CB LYS I 7 47.450 60.297 122.772 1.00 18.33 C +ATOM 13119 CG LYS I 7 47.143 61.699 122.268 1.00 26.17 C +ATOM 13120 CD LYS I 7 48.148 62.159 121.244 1.00 36.16 C +ATOM 13121 CE LYS I 7 47.875 63.582 120.794 1.00 46.55 C +ATOM 13122 NZ LYS I 7 49.008 64.095 119.967 1.00 61.28 N +ATOM 13123 N ALA I 8 45.945 57.749 123.632 1.00 9.60 N +ATOM 13124 CA ALA I 8 45.834 56.309 123.795 1.00 8.50 C +ATOM 13125 C ALA I 8 45.518 55.711 122.449 1.00 8.50 C +ATOM 13126 O ALA I 8 44.918 56.368 121.622 1.00 11.53 O +ATOM 13127 CB ALA I 8 44.712 55.979 124.781 1.00 8.50 C +ATOM 13128 N PHE I 9 45.992 54.497 122.202 1.00 10.80 N +ATOM 13129 CA PHE I 9 45.703 53.795 120.957 1.00 8.50 C +ATOM 13130 C PHE I 9 44.397 53.088 121.246 1.00 8.50 C +ATOM 13131 O PHE I 9 44.230 52.516 122.321 1.00 8.50 O +ATOM 13132 CB PHE I 9 46.758 52.734 120.661 1.00 8.50 C +ATOM 13133 CG PHE I 9 48.111 53.291 120.289 1.00 15.52 C +ATOM 13134 CD1 PHE I 9 48.269 54.094 119.162 1.00 8.50 C +ATOM 13135 CD2 PHE I 9 49.244 52.974 121.047 1.00 14.66 C +ATOM 13136 CE1 PHE I 9 49.535 54.565 118.802 1.00 8.50 C +ATOM 13137 CE2 PHE I 9 50.512 53.446 120.688 1.00 8.50 C +ATOM 13138 CZ PHE I 9 50.657 54.238 119.569 1.00 8.50 C +ATOM 13139 N VAL I 10 43.463 53.133 120.309 1.00 8.75 N +ATOM 13140 CA VAL I 10 42.174 52.481 120.499 1.00 10.57 C +ATOM 13141 C VAL I 10 41.802 51.502 119.372 1.00 9.37 C +ATOM 13142 O VAL I 10 41.768 51.859 118.206 1.00 8.50 O +ATOM 13143 CB VAL I 10 41.038 53.520 120.800 1.00 8.50 C +ATOM 13144 CG1 VAL I 10 41.329 54.833 120.128 1.00 8.50 C +ATOM 13145 CG2 VAL I 10 39.666 52.985 120.400 1.00 8.50 C +ATOM 13146 N PHE I 11 41.622 50.236 119.749 1.00 12.32 N +ATOM 13147 CA PHE I 11 41.254 49.139 118.848 1.00 8.97 C +ATOM 13148 C PHE I 11 39.757 48.914 119.071 1.00 9.42 C +ATOM 13149 O PHE I 11 39.366 48.155 119.950 1.00 8.50 O +ATOM 13150 CB PHE I 11 42.025 47.872 119.239 1.00 8.50 C +ATOM 13151 CG PHE I 11 43.510 48.065 119.337 1.00 8.50 C +ATOM 13152 CD1 PHE I 11 44.312 47.933 118.229 1.00 8.50 C +ATOM 13153 CD2 PHE I 11 44.104 48.396 120.535 1.00 8.50 C +ATOM 13154 CE1 PHE I 11 45.680 48.132 118.309 1.00 8.50 C +ATOM 13155 CE2 PHE I 11 45.473 48.597 120.623 1.00 8.50 C +ATOM 13156 CZ PHE I 11 46.255 48.464 119.509 1.00 8.50 C +ATOM 13157 N PRO I 12 38.901 49.558 118.257 1.00 12.62 N +ATOM 13158 CA PRO I 12 37.433 49.485 118.331 1.00 10.69 C +ATOM 13159 C PRO I 12 36.772 48.152 118.108 1.00 19.19 C +ATOM 13160 O PRO I 12 35.693 47.924 118.637 1.00 25.12 O +ATOM 13161 CB PRO I 12 36.970 50.499 117.276 1.00 8.50 C +ATOM 13162 CG PRO I 12 38.146 51.409 117.101 1.00 13.96 C +ATOM 13163 CD PRO I 12 39.305 50.440 117.149 1.00 18.65 C +ATOM 13164 N LYS I 13 37.356 47.300 117.264 1.00 32.01 N +ATOM 13165 CA LYS I 13 36.751 45.993 116.999 1.00 34.20 C +ATOM 13166 C LYS I 13 37.706 44.821 116.923 1.00 33.35 C +ATOM 13167 O LYS I 13 38.906 44.990 116.680 1.00 30.64 O +ATOM 13168 CB LYS I 13 35.813 46.023 115.777 1.00 34.06 C +ATOM 13169 CG LYS I 13 36.333 46.717 114.530 1.00 39.16 C +ATOM 13170 CD LYS I 13 35.195 46.842 113.508 1.00 49.73 C +ATOM 13171 CE LYS I 13 35.579 47.683 112.293 1.00 60.84 C +ATOM 13172 NZ LYS I 13 36.685 47.081 111.483 1.00 71.03 N +ATOM 13173 N GLU I 14 37.150 43.634 117.169 1.00 36.77 N +ATOM 13174 CA GLU I 14 37.911 42.387 117.155 1.00 42.68 C +ATOM 13175 C GLU I 14 38.536 42.170 115.787 1.00 42.65 C +ATOM 13176 O GLU I 14 37.844 42.099 114.767 1.00 44.13 O +ATOM 13177 CB GLU I 14 37.026 41.191 117.547 1.00 40.58 C +ATOM 13178 CG GLU I 14 37.807 39.899 117.769 1.00 47.23 C +ATOM 13179 CD GLU I 14 36.950 38.747 118.275 1.00 58.34 C +ATOM 13180 OE1 GLU I 14 36.421 38.840 119.412 1.00 56.65 O +ATOM 13181 OE2 GLU I 14 36.824 37.740 117.534 1.00 65.74 O +ATOM 13182 N SER I 15 39.855 42.097 115.770 1.00 43.44 N +ATOM 13183 CA SER I 15 40.565 41.912 114.529 1.00 42.30 C +ATOM 13184 C SER I 15 41.620 40.822 114.566 1.00 42.55 C +ATOM 13185 O SER I 15 41.902 40.215 115.597 1.00 39.66 O +ATOM 13186 CB SER I 15 41.174 43.232 114.067 1.00 47.01 C +ATOM 13187 OG SER I 15 41.920 43.855 115.098 1.00 62.22 O +ATOM 13188 N ASP I 16 42.161 40.573 113.387 1.00 44.89 N +ATOM 13189 CA ASP I 16 43.168 39.564 113.137 1.00 45.44 C +ATOM 13190 C ASP I 16 44.350 40.345 112.589 1.00 40.43 C +ATOM 13191 O ASP I 16 45.485 39.888 112.621 1.00 37.56 O +ATOM 13192 CB ASP I 16 42.602 38.642 112.033 1.00 58.06 C +ATOM 13193 CG ASP I 16 43.204 37.249 112.032 1.00 67.35 C +ATOM 13194 OD1 ASP I 16 43.710 36.791 113.083 1.00 78.09 O +ATOM 13195 OD2 ASP I 16 43.136 36.596 110.967 1.00 65.89 O +ATOM 13196 N THR I 17 44.055 41.570 112.161 1.00 39.54 N +ATOM 13197 CA THR I 17 45.013 42.467 111.523 1.00 41.02 C +ATOM 13198 C THR I 17 45.501 43.744 112.239 1.00 41.59 C +ATOM 13199 O THR I 17 46.540 44.301 111.858 1.00 42.93 O +ATOM 13200 CB THR I 17 44.430 42.906 110.175 1.00 42.89 C +ATOM 13201 OG1 THR I 17 43.085 43.379 110.368 1.00 32.82 O +ATOM 13202 CG2 THR I 17 44.400 41.724 109.218 1.00 50.82 C +ATOM 13203 N SER I 18 44.749 44.232 113.225 1.00 35.54 N +ATOM 13204 CA SER I 18 45.124 45.450 113.930 1.00 20.25 C +ATOM 13205 C SER I 18 46.160 45.256 115.035 1.00 17.26 C +ATOM 13206 O SER I 18 46.064 44.339 115.848 1.00 14.00 O +ATOM 13207 CB SER I 18 43.882 46.124 114.501 1.00 17.54 C +ATOM 13208 OG SER I 18 42.903 46.329 113.503 1.00 16.26 O +ATOM 13209 N TYR I 19 47.150 46.138 115.046 1.00 12.63 N +ATOM 13210 CA TYR I 19 48.210 46.134 116.039 1.00 13.13 C +ATOM 13211 C TYR I 19 49.126 47.352 115.863 1.00 11.98 C +ATOM 13212 O TYR I 19 49.077 48.022 114.843 1.00 8.70 O +ATOM 13213 CB TYR I 19 49.030 44.846 115.950 1.00 19.54 C +ATOM 13214 CG TYR I 19 49.911 44.727 114.715 1.00 25.18 C +ATOM 13215 CD1 TYR I 19 51.206 45.255 114.692 1.00 20.57 C +ATOM 13216 CD2 TYR I 19 49.461 44.056 113.586 1.00 28.21 C +ATOM 13217 CE1 TYR I 19 52.015 45.112 113.586 1.00 25.29 C +ATOM 13218 CE2 TYR I 19 50.268 43.906 112.470 1.00 29.28 C +ATOM 13219 CZ TYR I 19 51.544 44.436 112.478 1.00 29.89 C +ATOM 13220 OH TYR I 19 52.365 44.282 111.385 1.00 40.27 O +ATOM 13221 N VAL I 20 49.946 47.636 116.873 1.00 14.21 N +ATOM 13222 CA VAL I 20 50.878 48.757 116.849 1.00 8.50 C +ATOM 13223 C VAL I 20 52.213 48.201 117.243 1.00 11.15 C +ATOM 13224 O VAL I 20 52.333 47.535 118.258 1.00 12.08 O +ATOM 13225 CB VAL I 20 50.518 49.844 117.869 1.00 8.50 C +ATOM 13226 CG1 VAL I 20 51.552 50.909 117.860 1.00 8.50 C +ATOM 13227 CG2 VAL I 20 49.172 50.438 117.552 1.00 16.38 C +ATOM 13228 N SER I 21 53.206 48.440 116.406 1.00 16.84 N +ATOM 13229 CA SER I 21 54.563 47.969 116.637 1.00 15.09 C +ATOM 13230 C SER I 21 55.378 49.073 117.280 1.00 13.72 C +ATOM 13231 O SER I 21 55.367 50.215 116.826 1.00 17.48 O +ATOM 13232 CB SER I 21 55.209 47.551 115.317 1.00 13.93 C +ATOM 13233 OG SER I 21 56.510 47.051 115.520 1.00 23.85 O +ATOM 13234 N LEU I 22 56.061 48.737 118.362 1.00 11.15 N +ATOM 13235 CA LEU I 22 56.884 49.692 119.088 1.00 9.84 C +ATOM 13236 C LEU I 22 58.342 49.378 118.805 1.00 20.34 C +ATOM 13237 O LEU I 22 58.774 48.217 118.876 1.00 24.60 O +ATOM 13238 CB LEU I 22 56.601 49.599 120.587 1.00 9.77 C +ATOM 13239 CG LEU I 22 55.592 50.556 121.239 1.00 10.61 C +ATOM 13240 CD1 LEU I 22 54.395 50.850 120.377 1.00 8.50 C +ATOM 13241 CD2 LEU I 22 55.162 49.979 122.565 1.00 8.50 C +ATOM 13242 N LYS I 23 59.091 50.411 118.432 1.00 27.54 N +ATOM 13243 CA LYS I 23 60.516 50.279 118.115 1.00 30.92 C +ATOM 13244 C LYS I 23 61.383 50.739 119.262 1.00 31.84 C +ATOM 13245 O LYS I 23 61.387 51.910 119.627 1.00 30.91 O +ATOM 13246 CB LYS I 23 60.918 51.094 116.881 1.00 20.45 C +ATOM 13247 CG LYS I 23 61.044 50.316 115.571 1.00 29.82 C +ATOM 13248 CD LYS I 23 59.730 50.316 114.796 1.00 42.47 C +ATOM 13249 CE LYS I 23 59.950 50.064 113.305 1.00 60.95 C +ATOM 13250 NZ LYS I 23 58.679 50.145 112.500 1.00 67.29 N +ATOM 13251 N ALA I 24 62.127 49.804 119.824 1.00 42.69 N +ATOM 13252 CA ALA I 24 63.022 50.102 120.925 1.00 53.98 C +ATOM 13253 C ALA I 24 64.453 49.984 120.429 1.00 64.79 C +ATOM 13254 O ALA I 24 64.805 49.016 119.755 1.00 70.79 O +ATOM 13255 CB ALA I 24 62.791 49.134 122.063 1.00 55.29 C +ATOM 13256 N PRO I 25 65.284 50.996 120.706 1.00 72.74 N +ATOM 13257 CA PRO I 25 66.688 50.999 120.287 1.00 77.89 C +ATOM 13258 C PRO I 25 67.551 50.269 121.307 1.00 78.64 C +ATOM 13259 O PRO I 25 68.394 50.862 121.977 1.00 77.36 O +ATOM 13260 CB PRO I 25 67.013 52.484 120.228 1.00 82.68 C +ATOM 13261 CG PRO I 25 66.212 53.031 121.360 1.00 79.10 C +ATOM 13262 CD PRO I 25 64.889 52.311 121.241 1.00 76.82 C +ATOM 13263 N LEU I 26 67.328 48.968 121.407 1.00 81.02 N +ATOM 13264 CA LEU I 26 68.050 48.135 122.350 1.00 82.62 C +ATOM 13265 C LEU I 26 69.339 47.580 121.760 1.00 85.75 C +ATOM 13266 O LEU I 26 69.376 47.155 120.597 1.00 86.09 O +ATOM 13267 CB LEU I 26 67.141 47.002 122.833 1.00 82.27 C +ATOM 13268 CG LEU I 26 67.082 46.742 124.344 1.00 76.65 C +ATOM 13269 CD1 LEU I 26 67.155 48.045 125.147 1.00 74.51 C +ATOM 13270 CD2 LEU I 26 65.798 45.991 124.649 1.00 72.59 C +ATOM 13271 N THR I 27 70.397 47.617 122.571 1.00 88.59 N +ATOM 13272 CA THR I 27 71.726 47.134 122.182 1.00 88.36 C +ATOM 13273 C THR I 27 72.186 45.997 123.098 1.00 82.73 C +ATOM 13274 O THR I 27 72.687 44.970 122.630 1.00 83.31 O +ATOM 13275 CB THR I 27 72.777 48.278 122.236 1.00 89.66 C +ATOM 13276 OG1 THR I 27 72.678 48.961 123.494 1.00 89.69 O +ATOM 13277 CG2 THR I 27 72.561 49.271 121.095 1.00 91.80 C +ATOM 13278 N LYS I 28 72.048 46.210 124.405 1.00 76.01 N +ATOM 13279 CA LYS I 28 72.429 45.219 125.409 1.00 69.37 C +ATOM 13280 C LYS I 28 71.221 44.363 125.754 1.00 60.58 C +ATOM 13281 O LYS I 28 70.090 44.846 125.735 1.00 66.23 O +ATOM 13282 CB LYS I 28 72.904 45.914 126.686 1.00 78.11 C +ATOM 13283 CG LYS I 28 74.322 46.467 126.642 1.00 91.77 C +ATOM 13284 CD LYS I 28 75.359 45.360 126.795 1.00 97.12 C +ATOM 13285 CE LYS I 28 76.772 45.926 126.834 1.00102.15 C +ATOM 13286 NZ LYS I 28 77.781 44.858 127.070 1.00102.72 N +ATOM 13287 N PRO I 29 71.432 43.059 125.985 1.00 49.67 N +ATOM 13288 CA PRO I 29 70.327 42.161 126.339 1.00 42.73 C +ATOM 13289 C PRO I 29 69.880 42.453 127.778 1.00 35.88 C +ATOM 13290 O PRO I 29 70.690 42.826 128.625 1.00 35.76 O +ATOM 13291 CB PRO I 29 70.953 40.779 126.176 1.00 39.74 C +ATOM 13292 CG PRO I 29 72.390 41.021 126.466 1.00 47.12 C +ATOM 13293 CD PRO I 29 72.667 42.300 125.733 1.00 47.18 C +ATOM 13294 N LEU I 30 68.590 42.305 128.044 1.00 27.48 N +ATOM 13295 CA LEU I 30 68.043 42.602 129.363 1.00 22.69 C +ATOM 13296 C LEU I 30 68.308 41.578 130.483 1.00 21.67 C +ATOM 13297 O LEU I 30 68.059 40.384 130.334 1.00 17.31 O +ATOM 13298 CB LEU I 30 66.534 42.881 129.277 1.00 14.99 C +ATOM 13299 CG LEU I 30 65.954 44.093 128.549 1.00 8.50 C +ATOM 13300 CD1 LEU I 30 66.979 45.154 128.356 1.00 8.50 C +ATOM 13301 CD2 LEU I 30 65.380 43.657 127.225 1.00 12.62 C +ATOM 13302 N LYS I 31 68.759 42.086 131.627 1.00 19.80 N +ATOM 13303 CA LYS I 31 69.042 41.292 132.818 1.00 17.13 C +ATOM 13304 C LYS I 31 68.007 41.614 133.903 1.00 17.35 C +ATOM 13305 O LYS I 31 68.049 41.068 135.016 1.00 14.57 O +ATOM 13306 CB LYS I 31 70.449 41.613 133.337 1.00 22.18 C +ATOM 13307 CG LYS I 31 71.574 40.921 132.580 1.00 44.93 C +ATOM 13308 CD LYS I 31 71.529 39.410 132.799 1.00 63.19 C +ATOM 13309 CE LYS I 31 72.584 38.667 131.990 1.00 69.03 C +ATOM 13310 NZ LYS I 31 72.510 37.189 132.227 1.00 80.36 N +ATOM 13311 N ALA I 32 67.117 42.544 133.570 1.00 18.03 N +ATOM 13312 CA ALA I 32 66.037 43.013 134.433 1.00 11.47 C +ATOM 13313 C ALA I 32 65.228 44.010 133.605 1.00 9.60 C +ATOM 13314 O ALA I 32 65.684 44.439 132.546 1.00 10.79 O +ATOM 13315 CB ALA I 32 66.611 43.702 135.658 1.00 20.12 C +ATOM 13316 N PHE I 33 64.031 44.357 134.062 1.00 9.00 N +ATOM 13317 CA PHE I 33 63.194 45.316 133.350 1.00 9.31 C +ATOM 13318 C PHE I 33 61.942 45.650 134.146 1.00 13.66 C +ATOM 13319 O PHE I 33 61.590 44.929 135.089 1.00 18.06 O +ATOM 13320 CB PHE I 33 62.801 44.772 131.966 1.00 8.50 C +ATOM 13321 CG PHE I 33 61.937 43.531 132.001 1.00 8.50 C +ATOM 13322 CD1 PHE I 33 60.546 43.629 132.055 1.00 8.50 C +ATOM 13323 CD2 PHE I 33 62.513 42.267 131.952 1.00 9.87 C +ATOM 13324 CE1 PHE I 33 59.753 42.499 132.060 1.00 8.50 C +ATOM 13325 CE2 PHE I 33 61.720 41.129 131.955 1.00 9.15 C +ATOM 13326 CZ PHE I 33 60.335 41.250 132.010 1.00 8.50 C +ATOM 13327 N THR I 34 61.302 46.764 133.796 1.00 10.49 N +ATOM 13328 CA THR I 34 60.053 47.192 134.423 1.00 8.70 C +ATOM 13329 C THR I 34 59.241 47.740 133.279 1.00 8.50 C +ATOM 13330 O THR I 34 59.751 48.531 132.492 1.00 11.39 O +ATOM 13331 CB THR I 34 60.239 48.359 135.423 1.00 8.50 C +ATOM 13332 OG1 THR I 34 61.195 48.010 136.424 1.00 18.60 O +ATOM 13333 CG2 THR I 34 58.932 48.680 136.112 1.00 8.50 C +ATOM 13334 N VAL I 35 58.016 47.275 133.130 1.00 8.50 N +ATOM 13335 CA VAL I 35 57.158 47.788 132.080 1.00 9.62 C +ATOM 13336 C VAL I 35 55.821 48.146 132.720 1.00 12.72 C +ATOM 13337 O VAL I 35 55.241 47.347 133.469 1.00 12.87 O +ATOM 13338 CB VAL I 35 57.000 46.800 130.882 1.00 8.50 C +ATOM 13339 CG1 VAL I 35 57.383 45.409 131.282 1.00 16.14 C +ATOM 13340 CG2 VAL I 35 55.571 46.810 130.353 1.00 8.50 C +ATOM 13341 N CYS I 36 55.403 49.392 132.518 1.00 12.47 N +ATOM 13342 CA CYS I 36 54.147 49.893 133.066 1.00 11.31 C +ATOM 13343 C CYS I 36 53.264 50.325 131.900 1.00 9.88 C +ATOM 13344 O CYS I 36 53.779 50.700 130.851 1.00 13.00 O +ATOM 13345 CB CYS I 36 54.417 51.088 133.976 1.00 12.43 C +ATOM 13346 SG CYS I 36 55.492 50.786 135.432 1.00 10.81 S +ATOM 13347 N LEU I 37 51.951 50.222 132.065 1.00 8.50 N +ATOM 13348 CA LEU I 37 51.012 50.607 131.024 1.00 8.50 C +ATOM 13349 C LEU I 37 49.603 50.764 131.577 1.00 8.74 C +ATOM 13350 O LEU I 37 49.318 50.344 132.689 1.00 10.98 O +ATOM 13351 CB LEU I 37 51.038 49.607 129.869 1.00 8.50 C +ATOM 13352 CG LEU I 37 50.689 48.149 130.094 1.00 8.50 C +ATOM 13353 CD1 LEU I 37 49.214 47.945 129.916 1.00 8.50 C +ATOM 13354 CD2 LEU I 37 51.445 47.313 129.106 1.00 8.50 C +ATOM 13355 N HIS I 38 48.735 51.401 130.810 1.00 8.50 N +ATOM 13356 CA HIS I 38 47.356 51.646 131.205 1.00 8.50 C +ATOM 13357 C HIS I 38 46.514 51.002 130.119 1.00 11.88 C +ATOM 13358 O HIS I 38 46.787 51.203 128.937 1.00 21.02 O +ATOM 13359 CB HIS I 38 47.094 53.143 131.144 1.00 14.58 C +ATOM 13360 CG HIS I 38 46.667 53.762 132.433 1.00 8.50 C +ATOM 13361 ND1 HIS I 38 47.391 54.764 133.042 1.00 8.50 N +ATOM 13362 CD2 HIS I 38 45.557 53.587 133.180 1.00 8.50 C +ATOM 13363 CE1 HIS I 38 46.746 55.177 134.113 1.00 15.16 C +ATOM 13364 NE2 HIS I 38 45.628 54.479 134.217 1.00 8.50 N +ATOM 13365 N PHE I 39 45.505 50.232 130.485 1.00 8.50 N +ATOM 13366 CA PHE I 39 44.653 49.626 129.476 1.00 8.50 C +ATOM 13367 C PHE I 39 43.224 49.675 129.969 1.00 8.50 C +ATOM 13368 O PHE I 39 42.981 49.858 131.158 1.00 11.59 O +ATOM 13369 CB PHE I 39 45.099 48.191 129.104 1.00 8.50 C +ATOM 13370 CG PHE I 39 44.820 47.139 130.158 1.00 8.50 C +ATOM 13371 CD1 PHE I 39 45.718 46.912 131.184 1.00 8.50 C +ATOM 13372 CD2 PHE I 39 43.669 46.376 130.104 1.00 8.50 C +ATOM 13373 CE1 PHE I 39 45.475 45.960 132.123 1.00 8.50 C +ATOM 13374 CE2 PHE I 39 43.418 45.428 131.033 1.00 8.50 C +ATOM 13375 CZ PHE I 39 44.316 45.213 132.046 1.00 10.68 C +ATOM 13376 N TYR I 40 42.273 49.555 129.059 1.00 8.50 N +ATOM 13377 CA TYR I 40 40.881 49.608 129.434 1.00 8.50 C +ATOM 13378 C TYR I 40 40.082 48.800 128.433 1.00 8.82 C +ATOM 13379 O TYR I 40 39.903 49.230 127.298 1.00 10.92 O +ATOM 13380 CB TYR I 40 40.425 51.065 129.421 1.00 8.50 C +ATOM 13381 CG TYR I 40 38.992 51.283 129.816 1.00 8.50 C +ATOM 13382 CD1 TYR I 40 38.332 50.364 130.610 1.00 9.93 C +ATOM 13383 CD2 TYR I 40 38.296 52.407 129.402 1.00 8.50 C +ATOM 13384 CE1 TYR I 40 37.016 50.546 130.985 1.00 9.55 C +ATOM 13385 CE2 TYR I 40 36.975 52.604 129.774 1.00 10.23 C +ATOM 13386 CZ TYR I 40 36.342 51.662 130.570 1.00 11.50 C +ATOM 13387 OH TYR I 40 35.037 51.815 130.966 1.00 11.54 O +ATOM 13388 N THR I 41 39.584 47.639 128.856 1.00 11.98 N +ATOM 13389 CA THR I 41 38.807 46.761 127.976 1.00 11.55 C +ATOM 13390 C THR I 41 37.619 46.123 128.683 1.00 15.23 C +ATOM 13391 O THR I 41 37.551 46.101 129.915 1.00 14.02 O +ATOM 13392 CB THR I 41 39.694 45.635 127.374 1.00 12.42 C +ATOM 13393 OG1 THR I 41 38.926 44.863 126.441 1.00 9.41 O +ATOM 13394 CG2 THR I 41 40.229 44.733 128.474 1.00 8.50 C +ATOM 13395 N GLU I 42 36.722 45.538 127.895 1.00 18.53 N +ATOM 13396 CA GLU I 42 35.521 44.900 128.430 1.00 24.25 C +ATOM 13397 C GLU I 42 35.539 43.378 128.216 1.00 27.73 C +ATOM 13398 O GLU I 42 34.544 42.694 128.432 1.00 31.26 O +ATOM 13399 CB GLU I 42 34.303 45.491 127.725 1.00 26.63 C +ATOM 13400 CG GLU I 42 33.096 45.720 128.607 1.00 43.55 C +ATOM 13401 CD GLU I 42 32.078 46.670 127.974 1.00 49.57 C +ATOM 13402 OE1 GLU I 42 31.206 46.203 127.209 1.00 50.90 O +ATOM 13403 OE2 GLU I 42 32.155 47.892 128.241 1.00 52.57 O +ATOM 13404 N LEU I 43 36.635 42.878 127.644 1.00 25.68 N +ATOM 13405 CA LEU I 43 36.802 41.457 127.339 1.00 16.13 C +ATOM 13406 C LEU I 43 36.952 40.564 128.555 1.00 16.41 C +ATOM 13407 O LEU I 43 36.526 39.421 128.534 1.00 20.50 O +ATOM 13408 CB LEU I 43 38.028 41.254 126.447 1.00 10.10 C +ATOM 13409 CG LEU I 43 37.973 41.303 124.920 1.00 8.50 C +ATOM 13410 CD1 LEU I 43 36.890 42.224 124.418 1.00 22.17 C +ATOM 13411 CD2 LEU I 43 39.347 41.727 124.428 1.00 8.50 C +ATOM 13412 N SER I 44 37.596 41.072 129.590 1.00 16.88 N +ATOM 13413 CA SER I 44 37.854 40.329 130.820 1.00 23.70 C +ATOM 13414 C SER I 44 36.836 39.246 131.233 1.00 30.93 C +ATOM 13415 O SER I 44 37.207 38.191 131.772 1.00 29.98 O +ATOM 13416 CB SER I 44 38.013 41.313 131.980 1.00 28.09 C +ATOM 13417 OG SER I 44 38.894 42.369 131.654 1.00 42.86 O +ATOM 13418 N SER I 45 35.561 39.517 130.990 1.00 35.06 N +ATOM 13419 CA SER I 45 34.475 38.615 131.365 1.00 41.49 C +ATOM 13420 C SER I 45 34.114 37.517 130.365 1.00 38.39 C +ATOM 13421 O SER I 45 33.307 36.647 130.684 1.00 42.57 O +ATOM 13422 CB SER I 45 33.206 39.434 131.653 1.00 59.48 C +ATOM 13423 OG SER I 45 33.473 40.548 132.500 1.00 76.99 O +ATOM 13424 N THR I 46 34.651 37.582 129.150 1.00 30.13 N +ATOM 13425 CA THR I 46 34.334 36.587 128.139 1.00 22.91 C +ATOM 13426 C THR I 46 35.523 35.816 127.557 1.00 26.86 C +ATOM 13427 O THR I 46 35.433 34.599 127.425 1.00 36.46 O +ATOM 13428 CB THR I 46 33.488 37.181 126.981 1.00 18.72 C +ATOM 13429 OG1 THR I 46 34.333 37.870 126.054 1.00 22.59 O +ATOM 13430 CG2 THR I 46 32.462 38.166 127.504 1.00 19.53 C +ATOM 13431 N ARG I 47 36.615 36.494 127.187 1.00 22.11 N +ATOM 13432 CA ARG I 47 37.784 35.805 126.622 1.00 16.10 C +ATOM 13433 C ARG I 47 39.107 36.333 127.135 1.00 9.80 C +ATOM 13434 O ARG I 47 39.125 37.239 127.934 1.00 17.10 O +ATOM 13435 CB ARG I 47 37.764 35.815 125.084 1.00 13.20 C +ATOM 13436 CG ARG I 47 38.049 37.142 124.415 1.00 15.00 C +ATOM 13437 CD ARG I 47 38.085 36.980 122.906 1.00 8.50 C +ATOM 13438 NE ARG I 47 38.270 38.241 122.200 1.00 10.62 N +ATOM 13439 CZ ARG I 47 39.451 38.787 121.939 1.00 12.83 C +ATOM 13440 NH1 ARG I 47 40.558 38.181 122.338 1.00 8.50 N +ATOM 13441 NH2 ARG I 47 39.527 39.919 121.240 1.00 17.19 N +ATOM 13442 N GLY I 48 40.204 35.706 126.730 1.00 11.37 N +ATOM 13443 CA GLY I 48 41.522 36.133 127.161 1.00 9.38 C +ATOM 13444 C GLY I 48 42.036 37.093 126.129 1.00 11.22 C +ATOM 13445 O GLY I 48 41.465 37.155 125.047 1.00 20.49 O +ATOM 13446 N TYR I 49 43.098 37.832 126.435 1.00 10.65 N +ATOM 13447 CA TYR I 49 43.653 38.816 125.489 1.00 12.78 C +ATOM 13448 C TYR I 49 45.078 39.217 125.803 1.00 8.50 C +ATOM 13449 O TYR I 49 45.494 39.143 126.949 1.00 16.03 O +ATOM 13450 CB TYR I 49 42.781 40.075 125.431 1.00 11.16 C +ATOM 13451 CG TYR I 49 42.472 40.678 126.771 1.00 8.50 C +ATOM 13452 CD1 TYR I 49 43.414 41.440 127.452 1.00 8.50 C +ATOM 13453 CD2 TYR I 49 41.234 40.480 127.361 1.00 9.58 C +ATOM 13454 CE1 TYR I 49 43.136 41.989 128.681 1.00 8.50 C +ATOM 13455 CE2 TYR I 49 40.939 41.021 128.588 1.00 9.13 C +ATOM 13456 CZ TYR I 49 41.898 41.779 129.247 1.00 8.50 C +ATOM 13457 OH TYR I 49 41.606 42.325 130.475 1.00 8.50 O +ATOM 13458 N SER I 50 45.814 39.655 124.789 1.00 9.97 N +ATOM 13459 CA SER I 50 47.199 40.030 124.973 1.00 17.28 C +ATOM 13460 C SER I 50 47.331 41.498 125.257 1.00 24.10 C +ATOM 13461 O SER I 50 46.801 42.336 124.525 1.00 32.35 O +ATOM 13462 CB SER I 50 48.019 39.678 123.744 1.00 22.85 C +ATOM 13463 OG SER I 50 49.354 40.138 123.877 1.00 32.33 O +ATOM 13464 N ILE I 51 48.052 41.813 126.326 1.00 22.88 N +ATOM 13465 CA ILE I 51 48.273 43.193 126.729 1.00 16.15 C +ATOM 13466 C ILE I 51 49.603 43.725 126.161 1.00 17.37 C +ATOM 13467 O ILE I 51 49.613 44.719 125.438 1.00 16.82 O +ATOM 13468 CB ILE I 51 48.238 43.306 128.263 1.00 8.50 C +ATOM 13469 CG1 ILE I 51 46.867 42.903 128.778 1.00 8.50 C +ATOM 13470 CG2 ILE I 51 48.536 44.700 128.696 1.00 12.83 C +ATOM 13471 CD1 ILE I 51 46.790 42.858 130.264 1.00 8.50 C +ATOM 13472 N PHE I 52 50.698 43.015 126.426 1.00 12.08 N +ATOM 13473 CA PHE I 52 52.026 43.405 125.969 1.00 8.50 C +ATOM 13474 C PHE I 52 52.768 42.169 125.478 1.00 13.76 C +ATOM 13475 O PHE I 52 52.925 41.217 126.234 1.00 16.59 O +ATOM 13476 CB PHE I 52 52.768 43.996 127.140 1.00 8.50 C +ATOM 13477 CG PHE I 52 54.078 44.604 126.788 1.00 9.07 C +ATOM 13478 CD1 PHE I 52 54.130 45.816 126.132 1.00 12.71 C +ATOM 13479 CD2 PHE I 52 55.275 43.992 127.161 1.00 9.30 C +ATOM 13480 CE1 PHE I 52 55.359 46.415 125.850 1.00 15.06 C +ATOM 13481 CE2 PHE I 52 56.515 44.583 126.886 1.00 8.50 C +ATOM 13482 CZ PHE I 52 56.557 45.789 126.232 1.00 9.50 C +ATOM 13483 N SER I 53 53.234 42.183 124.226 1.00 19.12 N +ATOM 13484 CA SER I 53 53.949 41.044 123.614 1.00 13.32 C +ATOM 13485 C SER I 53 55.344 41.397 123.104 1.00 8.50 C +ATOM 13486 O SER I 53 55.484 42.047 122.087 1.00 8.50 O +ATOM 13487 CB SER I 53 53.117 40.458 122.459 1.00 8.50 C +ATOM 13488 OG SER I 53 53.658 39.240 122.000 1.00 12.15 O +ATOM 13489 N TYR I 54 56.366 40.954 123.820 1.00 8.50 N +ATOM 13490 CA TYR I 54 57.770 41.196 123.472 1.00 14.14 C +ATOM 13491 C TYR I 54 58.338 39.871 122.936 1.00 24.45 C +ATOM 13492 O TYR I 54 58.550 38.926 123.697 1.00 26.48 O +ATOM 13493 CB TYR I 54 58.532 41.622 124.717 1.00 8.50 C +ATOM 13494 CG TYR I 54 59.964 42.034 124.518 1.00 8.50 C +ATOM 13495 CD1 TYR I 54 60.995 41.098 124.512 1.00 11.07 C +ATOM 13496 CD2 TYR I 54 60.305 43.368 124.455 1.00 8.50 C +ATOM 13497 CE1 TYR I 54 62.331 41.490 124.461 1.00 8.68 C +ATOM 13498 CE2 TYR I 54 61.631 43.772 124.403 1.00 10.53 C +ATOM 13499 CZ TYR I 54 62.634 42.833 124.410 1.00 8.60 C +ATOM 13500 OH TYR I 54 63.938 43.238 124.384 1.00 8.50 O +ATOM 13501 N ALA I 55 58.603 39.811 121.635 1.00 29.96 N +ATOM 13502 CA ALA I 55 59.096 38.589 121.014 1.00 31.83 C +ATOM 13503 C ALA I 55 60.469 38.676 120.373 1.00 34.44 C +ATOM 13504 O ALA I 55 60.854 39.721 119.863 1.00 35.50 O +ATOM 13505 CB ALA I 55 58.091 38.106 119.983 1.00 35.82 C +ATOM 13506 N THR I 56 61.171 37.544 120.361 1.00 38.04 N +ATOM 13507 CA THR I 56 62.500 37.409 119.766 1.00 39.55 C +ATOM 13508 C THR I 56 62.394 36.369 118.660 1.00 43.23 C +ATOM 13509 O THR I 56 61.414 35.626 118.585 1.00 43.49 O +ATOM 13510 CB THR I 56 63.524 36.852 120.754 1.00 34.35 C +ATOM 13511 OG1 THR I 56 63.317 37.434 122.038 1.00 44.14 O +ATOM 13512 CG2 THR I 56 64.943 37.151 120.278 1.00 42.23 C +ATOM 13513 N LYS I 57 63.413 36.308 117.810 1.00 47.20 N +ATOM 13514 CA LYS I 57 63.439 35.343 116.723 1.00 49.09 C +ATOM 13515 C LYS I 57 63.459 33.933 117.312 1.00 50.23 C +ATOM 13516 O LYS I 57 62.727 33.048 116.868 1.00 53.72 O +ATOM 13517 CB LYS I 57 64.652 35.595 115.812 1.00 45.72 C +ATOM 13518 CG LYS I 57 64.434 36.686 114.727 1.00 44.45 C +ATOM 13519 CD LYS I 57 65.729 37.055 113.965 1.00 38.15 C +ATOM 13520 CE LYS I 57 65.512 38.085 112.838 1.00 19.59 C +ATOM 13521 NZ LYS I 57 64.681 37.588 111.686 1.00 24.24 N +ATOM 13522 N ARG I 58 64.250 33.770 118.370 1.00 48.52 N +ATOM 13523 CA ARG I 58 64.403 32.501 119.083 1.00 44.97 C +ATOM 13524 C ARG I 58 63.228 32.130 119.975 1.00 40.56 C +ATOM 13525 O ARG I 58 62.854 30.970 120.077 1.00 39.09 O +ATOM 13526 CB ARG I 58 65.640 32.567 119.967 1.00 44.07 C +ATOM 13527 CG ARG I 58 65.728 31.462 121.011 1.00 41.28 C +ATOM 13528 CD ARG I 58 65.824 30.093 120.364 1.00 35.39 C +ATOM 13529 NE ARG I 58 64.943 29.120 121.004 1.00 23.32 N +ATOM 13530 CZ ARG I 58 65.357 28.158 121.832 1.00 40.12 C +ATOM 13531 NH1 ARG I 58 66.653 28.019 122.139 1.00 39.28 N +ATOM 13532 NH2 ARG I 58 64.465 27.331 122.369 1.00 46.46 N +ATOM 13533 N GLN I 59 62.673 33.123 120.650 1.00 40.40 N +ATOM 13534 CA GLN I 59 61.563 32.910 121.571 1.00 33.58 C +ATOM 13535 C GLN I 59 60.447 33.914 121.294 1.00 30.30 C +ATOM 13536 O GLN I 59 60.630 35.112 121.497 1.00 33.36 O +ATOM 13537 CB GLN I 59 62.083 33.055 123.008 1.00 30.42 C +ATOM 13538 CG GLN I 59 61.031 33.082 124.089 1.00 25.10 C +ATOM 13539 CD GLN I 59 60.188 31.834 124.117 1.00 26.66 C +ATOM 13540 OE1 GLN I 59 59.194 31.722 123.403 1.00 30.58 O +ATOM 13541 NE2 GLN I 59 60.561 30.897 124.964 1.00 33.91 N +ATOM 13542 N ASP I 60 59.298 33.418 120.841 1.00 28.08 N +ATOM 13543 CA ASP I 60 58.159 34.270 120.516 1.00 28.07 C +ATOM 13544 C ASP I 60 57.512 34.930 121.727 1.00 25.31 C +ATOM 13545 O ASP I 60 56.903 35.997 121.613 1.00 30.43 O +ATOM 13546 CB ASP I 60 57.107 33.499 119.702 1.00 37.26 C +ATOM 13547 CG ASP I 60 56.513 32.326 120.455 1.00 34.95 C +ATOM 13548 OD1 ASP I 60 57.282 31.478 120.949 1.00 50.16 O +ATOM 13549 OD2 ASP I 60 55.269 32.241 120.530 1.00 29.20 O +ATOM 13550 N ASN I 61 57.630 34.307 122.890 1.00 16.57 N +ATOM 13551 CA ASN I 61 57.056 34.875 124.099 1.00 8.50 C +ATOM 13552 C ASN I 61 58.166 35.181 125.093 1.00 9.57 C +ATOM 13553 O ASN I 61 58.235 34.570 126.154 1.00 12.30 O +ATOM 13554 CB ASN I 61 56.047 33.908 124.702 1.00 8.50 C +ATOM 13555 CG ASN I 61 54.828 33.710 123.828 1.00 26.20 C +ATOM 13556 OD1 ASN I 61 54.480 34.583 123.036 1.00 21.84 O +ATOM 13557 ND2 ASN I 61 54.176 32.550 123.954 1.00 38.95 N +ATOM 13558 N GLU I 62 59.053 36.113 124.731 1.00 12.89 N +ATOM 13559 CA GLU I 62 60.189 36.503 125.571 1.00 8.50 C +ATOM 13560 C GLU I 62 59.703 37.158 126.858 1.00 10.27 C +ATOM 13561 O GLU I 62 60.232 36.905 127.930 1.00 15.78 O +ATOM 13562 CB GLU I 62 61.137 37.412 124.802 1.00 8.50 C +ATOM 13563 CG GLU I 62 62.497 37.591 125.449 1.00 8.50 C +ATOM 13564 CD GLU I 62 63.325 36.333 125.436 1.00 10.97 C +ATOM 13565 OE1 GLU I 62 62.855 35.311 125.943 1.00 20.46 O +ATOM 13566 OE2 GLU I 62 64.458 36.350 124.925 1.00 26.21 O +ATOM 13567 N ILE I 63 58.745 38.062 126.736 1.00 13.23 N +ATOM 13568 CA ILE I 63 58.117 38.714 127.880 1.00 9.82 C +ATOM 13569 C ILE I 63 56.709 39.021 127.370 1.00 8.50 C +ATOM 13570 O ILE I 63 56.548 39.591 126.306 1.00 8.50 O +ATOM 13571 CB ILE I 63 58.914 39.956 128.454 1.00 8.50 C +ATOM 13572 CG1 ILE I 63 57.991 41.122 128.709 1.00 9.92 C +ATOM 13573 CG2 ILE I 63 60.069 40.374 127.603 1.00 11.49 C +ATOM 13574 CD1 ILE I 63 57.113 40.919 129.911 1.00 27.48 C +ATOM 13575 N LEU I 64 55.702 38.508 128.063 1.00 8.50 N +ATOM 13576 CA LEU I 64 54.317 38.692 127.659 1.00 10.29 C +ATOM 13577 C LEU I 64 53.365 38.848 128.848 1.00 17.32 C +ATOM 13578 O LEU I 64 53.427 38.076 129.811 1.00 17.76 O +ATOM 13579 CB LEU I 64 53.873 37.512 126.790 1.00 8.50 C +ATOM 13580 CG LEU I 64 52.391 37.326 126.477 1.00 8.50 C +ATOM 13581 CD1 LEU I 64 52.126 37.484 125.030 1.00 8.50 C +ATOM 13582 CD2 LEU I 64 51.984 35.960 126.882 1.00 12.38 C +ATOM 13583 N ILE I 65 52.510 39.871 128.781 1.00 15.16 N +ATOM 13584 CA ILE I 65 51.508 40.155 129.810 1.00 9.87 C +ATOM 13585 C ILE I 65 50.175 39.812 129.178 1.00 10.54 C +ATOM 13586 O ILE I 65 49.816 40.370 128.145 1.00 16.14 O +ATOM 13587 CB ILE I 65 51.539 41.613 130.211 1.00 8.50 C +ATOM 13588 CG1 ILE I 65 52.921 41.946 130.769 1.00 8.50 C +ATOM 13589 CG2 ILE I 65 50.461 41.879 131.224 1.00 12.56 C +ATOM 13590 CD1 ILE I 65 53.169 43.401 130.959 1.00 10.74 C +ATOM 13591 N PHE I 66 49.421 38.939 129.821 1.00 8.50 N +ATOM 13592 CA PHE I 66 48.171 38.460 129.259 1.00 12.55 C +ATOM 13593 C PHE I 66 47.098 38.306 130.324 1.00 10.51 C +ATOM 13594 O PHE I 66 47.401 38.040 131.480 1.00 9.83 O +ATOM 13595 CB PHE I 66 48.472 37.075 128.635 1.00 23.04 C +ATOM 13596 CG PHE I 66 47.374 36.506 127.778 1.00 30.56 C +ATOM 13597 CD1 PHE I 66 46.371 35.716 128.328 1.00 38.10 C +ATOM 13598 CD2 PHE I 66 47.377 36.716 126.409 1.00 33.61 C +ATOM 13599 CE1 PHE I 66 45.389 35.145 127.524 1.00 44.81 C +ATOM 13600 CE2 PHE I 66 46.403 36.151 125.598 1.00 37.64 C +ATOM 13601 CZ PHE I 66 45.406 35.364 126.156 1.00 46.02 C +ATOM 13602 N TRP I 67 45.837 38.449 129.937 1.00 8.50 N +ATOM 13603 CA TRP I 67 44.744 38.233 130.873 1.00 11.27 C +ATOM 13604 C TRP I 67 44.064 36.944 130.459 1.00 23.23 C +ATOM 13605 O TRP I 67 43.477 36.891 129.369 1.00 30.69 O +ATOM 13606 CB TRP I 67 43.709 39.335 130.798 1.00 10.33 C +ATOM 13607 CG TRP I 67 42.400 38.996 131.503 1.00 8.50 C +ATOM 13608 CD1 TRP I 67 41.272 38.489 130.939 1.00 8.50 C +ATOM 13609 CD2 TRP I 67 42.118 39.139 132.893 1.00 8.50 C +ATOM 13610 NE1 TRP I 67 40.305 38.302 131.885 1.00 8.50 N +ATOM 13611 CE2 TRP I 67 40.797 38.685 133.097 1.00 8.50 C +ATOM 13612 CE3 TRP I 67 42.857 39.600 133.993 1.00 8.50 C +ATOM 13613 CZ2 TRP I 67 40.203 38.667 134.349 1.00 8.50 C +ATOM 13614 CZ3 TRP I 67 42.273 39.585 135.236 1.00 8.50 C +ATOM 13615 CH2 TRP I 67 40.952 39.119 135.410 1.00 12.77 C +ATOM 13616 N SER I 68 44.156 35.900 131.286 1.00 22.34 N +ATOM 13617 CA SER I 68 43.506 34.639 130.956 1.00 15.90 C +ATOM 13618 C SER I 68 42.185 34.535 131.680 1.00 11.56 C +ATOM 13619 O SER I 68 42.118 34.516 132.899 1.00 8.50 O +ATOM 13620 CB SER I 68 44.400 33.428 131.221 1.00 16.97 C +ATOM 13621 OG SER I 68 44.659 33.228 132.586 1.00 27.84 O +ATOM 13622 N LYS I 69 41.132 34.544 130.881 1.00 16.81 N +ATOM 13623 CA LYS I 69 39.754 34.474 131.330 1.00 19.03 C +ATOM 13624 C LYS I 69 39.581 33.570 132.538 1.00 21.15 C +ATOM 13625 O LYS I 69 40.140 32.494 132.594 1.00 29.70 O +ATOM 13626 CB LYS I 69 38.898 33.970 130.170 1.00 21.19 C +ATOM 13627 CG LYS I 69 37.427 34.356 130.187 1.00 35.30 C +ATOM 13628 CD LYS I 69 36.605 33.513 131.146 1.00 45.28 C +ATOM 13629 CE LYS I 69 35.116 33.480 130.790 1.00 50.05 C +ATOM 13630 NZ LYS I 69 34.835 32.641 129.590 1.00 43.35 N +ATOM 13631 N ASP I 70 38.822 34.033 133.518 1.00 30.97 N +ATOM 13632 CA ASP I 70 38.538 33.277 134.734 1.00 32.92 C +ATOM 13633 C ASP I 70 39.701 33.004 135.668 1.00 36.34 C +ATOM 13634 O ASP I 70 39.522 32.334 136.673 1.00 47.22 O +ATOM 13635 CB ASP I 70 37.850 31.958 134.397 1.00 24.94 C +ATOM 13636 CG ASP I 70 36.374 32.117 134.097 1.00 45.33 C +ATOM 13637 OD1 ASP I 70 35.804 33.187 134.380 1.00 61.20 O +ATOM 13638 OD2 ASP I 70 35.767 31.162 133.573 1.00 52.99 O +ATOM 13639 N ILE I 71 40.891 33.494 135.354 1.00 34.54 N +ATOM 13640 CA ILE I 71 42.030 33.250 136.229 1.00 29.35 C +ATOM 13641 C ILE I 71 42.651 34.543 136.757 1.00 26.69 C +ATOM 13642 O ILE I 71 42.642 34.788 137.975 1.00 29.49 O +ATOM 13643 CB ILE I 71 43.113 32.389 135.528 1.00 25.78 C +ATOM 13644 CG1 ILE I 71 42.552 31.028 135.161 1.00 27.82 C +ATOM 13645 CG2 ILE I 71 44.315 32.179 136.429 1.00 18.51 C +ATOM 13646 CD1 ILE I 71 43.568 30.122 134.474 1.00 46.74 C +ATOM 13647 N GLY I 72 43.192 35.358 135.848 1.00 16.17 N +ATOM 13648 CA GLY I 72 43.826 36.600 136.243 1.00 11.85 C +ATOM 13649 C GLY I 72 44.951 36.985 135.311 1.00 8.97 C +ATOM 13650 O GLY I 72 44.942 36.646 134.137 1.00 9.16 O +ATOM 13651 N TYR I 73 45.922 37.710 135.833 1.00 8.50 N +ATOM 13652 CA TYR I 73 47.040 38.142 135.030 1.00 8.50 C +ATOM 13653 C TYR I 73 48.035 37.041 134.861 1.00 8.50 C +ATOM 13654 O TYR I 73 48.439 36.406 135.819 1.00 10.25 O +ATOM 13655 CB TYR I 73 47.709 39.365 135.652 1.00 8.50 C +ATOM 13656 CG TYR I 73 46.827 40.585 135.605 1.00 9.41 C +ATOM 13657 CD1 TYR I 73 46.616 41.269 134.408 1.00 9.42 C +ATOM 13658 CD2 TYR I 73 46.137 41.003 136.731 1.00 8.50 C +ATOM 13659 CE1 TYR I 73 45.733 42.330 134.339 1.00 11.92 C +ATOM 13660 CE2 TYR I 73 45.260 42.059 136.681 1.00 8.50 C +ATOM 13661 CZ TYR I 73 45.055 42.722 135.491 1.00 14.46 C +ATOM 13662 OH TYR I 73 44.193 43.797 135.465 1.00 18.87 O +ATOM 13663 N SER I 74 48.445 36.839 133.625 1.00 10.74 N +ATOM 13664 CA SER I 74 49.410 35.813 133.270 1.00 12.81 C +ATOM 13665 C SER I 74 50.693 36.487 132.810 1.00 8.61 C +ATOM 13666 O SER I 74 50.771 37.018 131.710 1.00 14.55 O +ATOM 13667 CB SER I 74 48.825 34.933 132.154 1.00 12.50 C +ATOM 13668 OG SER I 74 49.792 34.046 131.621 1.00 30.53 O +ATOM 13669 N PHE I 75 51.686 36.503 133.672 1.00 8.50 N +ATOM 13670 CA PHE I 75 52.950 37.124 133.333 1.00 9.66 C +ATOM 13671 C PHE I 75 53.948 36.040 132.940 1.00 13.18 C +ATOM 13672 O PHE I 75 54.305 35.185 133.754 1.00 9.85 O +ATOM 13673 CB PHE I 75 53.492 37.926 134.515 1.00 8.50 C +ATOM 13674 CG PHE I 75 54.824 38.569 134.245 1.00 8.50 C +ATOM 13675 CD1 PHE I 75 54.943 39.578 133.313 1.00 8.50 C +ATOM 13676 CD2 PHE I 75 55.964 38.143 134.905 1.00 11.97 C +ATOM 13677 CE1 PHE I 75 56.161 40.147 133.046 1.00 8.50 C +ATOM 13678 CE2 PHE I 75 57.194 38.710 134.639 1.00 8.50 C +ATOM 13679 CZ PHE I 75 57.288 39.713 133.707 1.00 9.33 C +ATOM 13680 N THR I 76 54.420 36.086 131.696 1.00 19.93 N +ATOM 13681 CA THR I 76 55.379 35.088 131.194 1.00 16.39 C +ATOM 13682 C THR I 76 56.652 35.695 130.603 1.00 10.71 C +ATOM 13683 O THR I 76 56.598 36.621 129.799 1.00 12.35 O +ATOM 13684 CB THR I 76 54.696 34.100 130.179 1.00 10.13 C +ATOM 13685 OG1 THR I 76 55.579 33.819 129.096 1.00 8.50 O +ATOM 13686 CG2 THR I 76 53.386 34.658 129.648 1.00 19.05 C +ATOM 13687 N VAL I 77 57.794 35.227 131.080 1.00 8.50 N +ATOM 13688 CA VAL I 77 59.077 35.712 130.590 1.00 17.83 C +ATOM 13689 C VAL I 77 59.941 34.513 130.232 1.00 21.15 C +ATOM 13690 O VAL I 77 60.092 33.594 131.028 1.00 26.11 O +ATOM 13691 CB VAL I 77 59.813 36.665 131.605 1.00 13.94 C +ATOM 13692 CG1 VAL I 77 59.503 36.281 133.029 1.00 18.16 C +ATOM 13693 CG2 VAL I 77 61.336 36.660 131.357 1.00 8.50 C +ATOM 13694 N GLY I 78 60.419 34.486 128.996 1.00 19.92 N +ATOM 13695 CA GLY I 78 61.255 33.402 128.533 1.00 14.94 C +ATOM 13696 C GLY I 78 60.450 32.136 128.323 1.00 22.18 C +ATOM 13697 O GLY I 78 60.937 31.035 128.599 1.00 32.74 O +ATOM 13698 N GLY I 79 59.214 32.276 127.848 1.00 19.37 N +ATOM 13699 CA GLY I 79 58.377 31.109 127.615 1.00 15.65 C +ATOM 13700 C GLY I 79 57.763 30.490 128.857 1.00 16.99 C +ATOM 13701 O GLY I 79 56.838 29.692 128.734 1.00 17.49 O +ATOM 13702 N SER I 80 58.258 30.849 130.043 1.00 18.86 N +ATOM 13703 CA SER I 80 57.741 30.326 131.309 1.00 18.61 C +ATOM 13704 C SER I 80 56.731 31.275 131.934 1.00 20.08 C +ATOM 13705 O SER I 80 57.017 32.455 132.167 1.00 28.38 O +ATOM 13706 CB SER I 80 58.887 30.036 132.273 1.00 26.27 C +ATOM 13707 OG SER I 80 59.713 28.976 131.790 1.00 42.23 O +ATOM 13708 N GLU I 81 55.543 30.737 132.194 1.00 18.43 N +ATOM 13709 CA GLU I 81 54.400 31.477 132.739 1.00 16.30 C +ATOM 13710 C GLU I 81 54.291 31.470 134.264 1.00 16.25 C +ATOM 13711 O GLU I 81 54.852 30.605 134.928 1.00 23.47 O +ATOM 13712 CB GLU I 81 53.127 30.893 132.120 1.00 8.50 C +ATOM 13713 CG GLU I 81 51.827 31.524 132.521 1.00 19.81 C +ATOM 13714 CD GLU I 81 50.618 30.697 132.095 1.00 26.57 C +ATOM 13715 OE1 GLU I 81 50.520 29.528 132.517 1.00 42.06 O +ATOM 13716 OE2 GLU I 81 49.757 31.205 131.352 1.00 22.64 O +ATOM 13717 N ILE I 82 53.575 32.452 134.803 1.00 14.71 N +ATOM 13718 CA ILE I 82 53.345 32.587 136.231 1.00 8.50 C +ATOM 13719 C ILE I 82 52.003 33.294 136.348 1.00 8.50 C +ATOM 13720 O ILE I 82 51.630 34.078 135.468 1.00 8.97 O +ATOM 13721 CB ILE I 82 54.484 33.351 136.902 1.00 8.50 C +ATOM 13722 CG1 ILE I 82 54.568 32.970 138.355 1.00 8.50 C +ATOM 13723 CG2 ILE I 82 54.292 34.840 136.810 1.00 13.33 C +ATOM 13724 CD1 ILE I 82 55.864 33.427 138.973 1.00 31.10 C +ATOM 13725 N LEU I 83 51.259 33.019 137.409 1.00 8.50 N +ATOM 13726 CA LEU I 83 49.936 33.613 137.537 1.00 8.66 C +ATOM 13727 C LEU I 83 49.675 34.504 138.725 1.00 12.16 C +ATOM 13728 O LEU I 83 50.144 34.253 139.823 1.00 16.26 O +ATOM 13729 CB LEU I 83 48.879 32.520 137.497 1.00 8.50 C +ATOM 13730 CG LEU I 83 48.182 32.174 136.186 1.00 8.50 C +ATOM 13731 CD1 LEU I 83 49.150 32.050 135.074 1.00 8.58 C +ATOM 13732 CD2 LEU I 83 47.444 30.901 136.335 1.00 14.20 C +ATOM 13733 N PHE I 84 48.894 35.543 138.481 1.00 14.21 N +ATOM 13734 CA PHE I 84 48.494 36.496 139.502 1.00 13.88 C +ATOM 13735 C PHE I 84 46.989 36.494 139.434 1.00 14.90 C +ATOM 13736 O PHE I 84 46.361 37.134 138.581 1.00 17.53 O +ATOM 13737 CB PHE I 84 49.090 37.870 139.240 1.00 8.50 C +ATOM 13738 CG PHE I 84 50.541 37.926 139.514 1.00 8.50 C +ATOM 13739 CD1 PHE I 84 51.001 37.777 140.793 1.00 8.50 C +ATOM 13740 CD2 PHE I 84 51.448 38.090 138.492 1.00 8.50 C +ATOM 13741 CE1 PHE I 84 52.339 37.789 141.062 1.00 8.50 C +ATOM 13742 CE2 PHE I 84 52.805 38.106 138.746 1.00 12.39 C +ATOM 13743 CZ PHE I 84 53.252 37.954 140.039 1.00 9.42 C +ATOM 13744 N GLU I 85 46.428 35.663 140.290 1.00 13.33 N +ATOM 13745 CA GLU I 85 45.001 35.464 140.350 1.00 22.70 C +ATOM 13746 C GLU I 85 44.207 36.695 140.728 1.00 23.36 C +ATOM 13747 O GLU I 85 44.573 37.433 141.636 1.00 28.92 O +ATOM 13748 CB GLU I 85 44.696 34.302 141.292 1.00 35.19 C +ATOM 13749 CG GLU I 85 45.563 33.073 141.015 1.00 55.13 C +ATOM 13750 CD GLU I 85 44.887 31.781 141.386 1.00 66.89 C +ATOM 13751 OE1 GLU I 85 45.009 31.368 142.557 1.00 79.38 O +ATOM 13752 OE2 GLU I 85 44.229 31.183 140.508 1.00 72.21 O +ATOM 13753 N VAL I 86 43.135 36.922 139.987 1.00 24.37 N +ATOM 13754 CA VAL I 86 42.241 38.040 140.217 1.00 35.28 C +ATOM 13755 C VAL I 86 40.826 37.474 140.106 1.00 45.23 C +ATOM 13756 O VAL I 86 40.306 37.312 139.009 1.00 54.25 O +ATOM 13757 CB VAL I 86 42.456 39.157 139.170 1.00 31.90 C +ATOM 13758 CG1 VAL I 86 41.364 40.207 139.285 1.00 35.98 C +ATOM 13759 CG2 VAL I 86 43.822 39.804 139.371 1.00 34.22 C +ATOM 13760 N PRO I 87 40.192 37.161 141.247 1.00 49.66 N +ATOM 13761 CA PRO I 87 38.839 36.603 141.345 1.00 58.28 C +ATOM 13762 C PRO I 87 37.692 37.487 140.846 1.00 70.45 C +ATOM 13763 O PRO I 87 36.971 37.113 139.914 1.00 75.27 O +ATOM 13764 CB PRO I 87 38.710 36.311 142.834 1.00 50.40 C +ATOM 13765 CG PRO I 87 39.509 37.391 143.446 1.00 53.91 C +ATOM 13766 CD PRO I 87 40.744 37.404 142.587 1.00 52.71 C +ATOM 13767 N GLU I 88 37.497 38.632 141.502 1.00 77.80 N +ATOM 13768 CA GLU I 88 36.438 39.583 141.148 1.00 78.07 C +ATOM 13769 C GLU I 88 36.989 40.573 140.113 1.00 71.86 C +ATOM 13770 O GLU I 88 37.843 41.413 140.434 1.00 67.36 O +ATOM 13771 CB GLU I 88 35.971 40.333 142.410 1.00 87.38 C +ATOM 13772 CG GLU I 88 34.650 41.095 142.271 1.00 98.30 C +ATOM 13773 CD GLU I 88 34.352 42.011 143.458 1.00 98.44 C +ATOM 13774 OE1 GLU I 88 34.584 41.609 144.615 1.00 96.28 O +ATOM 13775 OE2 GLU I 88 33.879 43.143 143.230 1.00103.29 O +ATOM 13776 N VAL I 89 36.547 40.433 138.866 1.00 67.83 N +ATOM 13777 CA VAL I 89 37.006 41.323 137.808 1.00 65.49 C +ATOM 13778 C VAL I 89 36.070 42.518 137.721 1.00 63.75 C +ATOM 13779 O VAL I 89 34.841 42.378 137.779 1.00 58.82 O +ATOM 13780 CB VAL I 89 37.102 40.611 136.434 1.00 58.67 C +ATOM 13781 CG1 VAL I 89 35.718 40.289 135.889 1.00 62.32 C +ATOM 13782 CG2 VAL I 89 37.884 41.456 135.467 1.00 55.37 C +ATOM 13783 N THR I 90 36.665 43.700 137.627 1.00 64.69 N +ATOM 13784 CA THR I 90 35.897 44.926 137.534 1.00 62.40 C +ATOM 13785 C THR I 90 36.220 45.649 136.222 1.00 51.84 C +ATOM 13786 O THR I 90 37.336 45.568 135.698 1.00 52.40 O +ATOM 13787 CB THR I 90 36.167 45.839 138.759 1.00 70.30 C +ATOM 13788 OG1 THR I 90 35.211 46.909 138.781 1.00 77.64 O +ATOM 13789 CG2 THR I 90 37.602 46.405 138.717 1.00 73.20 C +ATOM 13790 N VAL I 91 35.224 46.339 135.695 1.00 37.15 N +ATOM 13791 CA VAL I 91 35.383 47.064 134.465 1.00 35.31 C +ATOM 13792 C VAL I 91 35.695 48.539 134.746 1.00 33.84 C +ATOM 13793 O VAL I 91 34.852 49.274 135.264 1.00 42.15 O +ATOM 13794 CB VAL I 91 34.122 46.897 133.597 1.00 38.70 C +ATOM 13795 CG1 VAL I 91 32.876 47.317 134.376 1.00 41.20 C +ATOM 13796 CG2 VAL I 91 34.254 47.686 132.297 1.00 50.05 C +ATOM 13797 N ALA I 92 36.932 48.943 134.458 1.00 21.50 N +ATOM 13798 CA ALA I 92 37.397 50.313 134.665 1.00 10.31 C +ATOM 13799 C ALA I 92 38.804 50.340 134.139 1.00 8.50 C +ATOM 13800 O ALA I 92 39.394 49.280 133.969 1.00 9.82 O +ATOM 13801 CB ALA I 92 37.401 50.646 136.131 1.00 18.59 C +ATOM 13802 N PRO I 93 39.341 51.534 133.799 1.00 8.50 N +ATOM 13803 CA PRO I 93 40.711 51.512 133.295 1.00 8.50 C +ATOM 13804 C PRO I 93 41.568 50.956 134.401 1.00 9.93 C +ATOM 13805 O PRO I 93 41.247 51.131 135.586 1.00 20.82 O +ATOM 13806 CB PRO I 93 41.010 52.985 133.051 1.00 8.50 C +ATOM 13807 CG PRO I 93 39.710 53.530 132.692 1.00 8.50 C +ATOM 13808 CD PRO I 93 38.789 52.895 133.699 1.00 12.79 C +ATOM 13809 N VAL I 94 42.621 50.242 134.027 1.00 8.50 N +ATOM 13810 CA VAL I 94 43.509 49.650 135.006 1.00 8.50 C +ATOM 13811 C VAL I 94 44.938 49.951 134.622 1.00 8.50 C +ATOM 13812 O VAL I 94 45.243 50.102 133.447 1.00 8.50 O +ATOM 13813 CB VAL I 94 43.211 48.140 135.175 1.00 8.50 C +ATOM 13814 CG1 VAL I 94 42.870 47.520 133.861 1.00 19.43 C +ATOM 13815 CG2 VAL I 94 44.356 47.417 135.813 1.00 16.52 C +ATOM 13816 N HIS I 95 45.777 50.184 135.625 1.00 8.50 N +ATOM 13817 CA HIS I 95 47.176 50.523 135.411 1.00 8.50 C +ATOM 13818 C HIS I 95 48.029 49.447 136.030 1.00 12.47 C +ATOM 13819 O HIS I 95 47.858 49.155 137.210 1.00 20.96 O +ATOM 13820 CB HIS I 95 47.496 51.872 136.075 1.00 8.50 C +ATOM 13821 CG HIS I 95 48.951 52.204 136.118 1.00 8.50 C +ATOM 13822 ND1 HIS I 95 49.603 52.867 135.102 1.00 8.50 N +ATOM 13823 CD2 HIS I 95 49.886 51.951 137.059 1.00 8.50 C +ATOM 13824 CE1 HIS I 95 50.878 53.007 135.411 1.00 8.50 C +ATOM 13825 NE2 HIS I 95 51.075 52.458 136.596 1.00 13.66 N +ATOM 13826 N ILE I 96 48.945 48.859 135.259 1.00 11.28 N +ATOM 13827 CA ILE I 96 49.820 47.821 135.790 1.00 9.27 C +ATOM 13828 C ILE I 96 51.292 48.122 135.536 1.00 8.50 C +ATOM 13829 O ILE I 96 51.642 48.807 134.592 1.00 8.50 O +ATOM 13830 CB ILE I 96 49.492 46.420 135.210 1.00 8.50 C +ATOM 13831 CG1 ILE I 96 49.631 46.436 133.706 1.00 13.81 C +ATOM 13832 CG2 ILE I 96 48.092 45.982 135.567 1.00 8.50 C +ATOM 13833 CD1 ILE I 96 49.603 45.076 133.110 1.00 24.30 C +ATOM 13834 N CYS I 97 52.131 47.698 136.463 1.00 9.10 N +ATOM 13835 CA CYS I 97 53.581 47.843 136.357 1.00 10.19 C +ATOM 13836 C CYS I 97 54.043 46.470 136.780 1.00 12.07 C +ATOM 13837 O CYS I 97 53.550 45.927 137.781 1.00 9.72 O +ATOM 13838 CB CYS I 97 54.176 48.841 137.359 1.00 14.03 C +ATOM 13839 SG CYS I 97 54.169 50.611 136.961 1.00 8.50 S +ATOM 13840 N THR I 98 54.967 45.902 136.019 1.00 12.73 N +ATOM 13841 CA THR I 98 55.485 44.581 136.327 1.00 12.87 C +ATOM 13842 C THR I 98 57.000 44.609 136.110 1.00 8.86 C +ATOM 13843 O THR I 98 57.479 45.339 135.242 1.00 8.50 O +ATOM 13844 CB THR I 98 54.775 43.500 135.477 1.00 8.50 C +ATOM 13845 OG1 THR I 98 55.264 42.209 135.844 1.00 24.18 O +ATOM 13846 CG2 THR I 98 55.008 43.730 134.021 1.00 8.50 C +ATOM 13847 N SER I 99 57.745 43.882 136.945 1.00 8.50 N +ATOM 13848 CA SER I 99 59.196 43.853 136.858 1.00 8.50 C +ATOM 13849 C SER I 99 59.799 42.494 137.123 1.00 11.21 C +ATOM 13850 O SER I 99 59.225 41.689 137.839 1.00 19.59 O +ATOM 13851 CB SER I 99 59.828 44.892 137.791 1.00 11.61 C +ATOM 13852 OG SER I 99 59.400 44.801 139.148 1.00 13.07 O +ATOM 13853 N TRP I 100 60.966 42.245 136.537 1.00 13.99 N +ATOM 13854 CA TRP I 100 61.677 40.971 136.675 1.00 11.78 C +ATOM 13855 C TRP I 100 63.170 41.227 136.809 1.00 11.60 C +ATOM 13856 O TRP I 100 63.698 42.150 136.195 1.00 13.20 O +ATOM 13857 CB TRP I 100 61.392 40.072 135.464 1.00 12.41 C +ATOM 13858 CG TRP I 100 62.304 38.887 135.316 1.00 12.15 C +ATOM 13859 CD1 TRP I 100 62.194 37.690 135.943 1.00 11.98 C +ATOM 13860 CD2 TRP I 100 63.462 38.795 134.475 1.00 13.89 C +ATOM 13861 NE1 TRP I 100 63.213 36.860 135.555 1.00 17.53 N +ATOM 13862 CE2 TRP I 100 64.007 37.514 134.653 1.00 11.78 C +ATOM 13863 CE3 TRP I 100 64.092 39.677 133.584 1.00 20.76 C +ATOM 13864 CZ2 TRP I 100 65.157 37.087 133.975 1.00 16.54 C +ATOM 13865 CZ3 TRP I 100 65.241 39.248 132.904 1.00 14.31 C +ATOM 13866 CH2 TRP I 100 65.754 37.968 133.108 1.00 13.11 C +ATOM 13867 N GLU I 101 63.841 40.392 137.598 1.00 12.60 N +ATOM 13868 CA GLU I 101 65.275 40.522 137.847 1.00 16.60 C +ATOM 13869 C GLU I 101 65.951 39.162 137.659 1.00 20.30 C +ATOM 13870 O GLU I 101 65.655 38.228 138.401 1.00 24.12 O +ATOM 13871 CB GLU I 101 65.484 41.011 139.281 1.00 9.27 C +ATOM 13872 CG GLU I 101 66.939 41.111 139.725 1.00 26.70 C +ATOM 13873 CD GLU I 101 67.093 41.526 141.194 1.00 24.06 C +ATOM 13874 OE1 GLU I 101 66.807 40.710 142.095 1.00 11.18 O +ATOM 13875 OE2 GLU I 101 67.512 42.676 141.444 1.00 35.05 O +ATOM 13876 N SER I 102 66.870 39.054 136.697 1.00 18.87 N +ATOM 13877 CA SER I 102 67.557 37.793 136.446 1.00 15.12 C +ATOM 13878 C SER I 102 68.265 37.280 137.692 1.00 16.54 C +ATOM 13879 O SER I 102 68.106 36.129 138.073 1.00 24.77 O +ATOM 13880 CB SER I 102 68.558 37.946 135.305 1.00 12.54 C +ATOM 13881 OG SER I 102 69.429 36.839 135.205 1.00 11.11 O +ATOM 13882 N ALA I 103 68.988 38.156 138.366 1.00 14.24 N +ATOM 13883 CA ALA I 103 69.736 37.790 139.561 1.00 14.38 C +ATOM 13884 C ALA I 103 69.024 36.999 140.662 1.00 13.67 C +ATOM 13885 O ALA I 103 69.670 36.249 141.383 1.00 26.12 O +ATOM 13886 CB ALA I 103 70.392 39.022 140.150 1.00 19.91 C +ATOM 13887 N SER I 104 67.716 37.148 140.798 1.00 8.93 N +ATOM 13888 CA SER I 104 66.990 36.433 141.846 1.00 11.01 C +ATOM 13889 C SER I 104 65.719 35.734 141.341 1.00 13.33 C +ATOM 13890 O SER I 104 65.178 34.829 141.991 1.00 11.63 O +ATOM 13891 CB SER I 104 66.607 37.416 142.937 1.00 8.50 C +ATOM 13892 OG SER I 104 65.653 38.329 142.442 1.00 8.50 O +ATOM 13893 N GLY I 105 65.240 36.177 140.186 1.00 13.25 N +ATOM 13894 CA GLY I 105 64.045 35.619 139.607 1.00 9.07 C +ATOM 13895 C GLY I 105 62.823 36.273 140.198 1.00 11.24 C +ATOM 13896 O GLY I 105 61.710 35.908 139.855 1.00 18.74 O +ATOM 13897 N ILE I 106 63.010 37.249 141.073 1.00 8.50 N +ATOM 13898 CA ILE I 106 61.868 37.905 141.680 1.00 8.50 C +ATOM 13899 C ILE I 106 61.111 38.797 140.713 1.00 8.50 C +ATOM 13900 O ILE I 106 61.674 39.710 140.120 1.00 13.54 O +ATOM 13901 CB ILE I 106 62.258 38.721 142.915 1.00 8.50 C +ATOM 13902 CG1 ILE I 106 62.777 37.800 144.004 1.00 8.50 C +ATOM 13903 CG2 ILE I 106 61.057 39.458 143.446 1.00 8.50 C +ATOM 13904 CD1 ILE I 106 63.140 38.504 145.272 1.00 12.27 C +ATOM 13905 N VAL I 107 59.830 38.519 140.561 1.00 8.50 N +ATOM 13906 CA VAL I 107 58.972 39.292 139.701 1.00 8.50 C +ATOM 13907 C VAL I 107 57.879 39.910 140.576 1.00 8.96 C +ATOM 13908 O VAL I 107 57.349 39.248 141.458 1.00 11.38 O +ATOM 13909 CB VAL I 107 58.384 38.427 138.542 1.00 8.92 C +ATOM 13910 CG1 VAL I 107 58.001 37.043 139.021 1.00 11.84 C +ATOM 13911 CG2 VAL I 107 57.165 39.103 137.965 1.00 17.90 C +ATOM 13912 N GLU I 108 57.637 41.211 140.403 1.00 14.60 N +ATOM 13913 CA GLU I 108 56.617 41.965 141.151 1.00 9.73 C +ATOM 13914 C GLU I 108 55.515 42.325 140.152 1.00 10.64 C +ATOM 13915 O GLU I 108 55.778 42.520 138.966 1.00 8.79 O +ATOM 13916 CB GLU I 108 57.181 43.289 141.689 1.00 8.50 C +ATOM 13917 CG GLU I 108 58.346 43.238 142.670 1.00 8.50 C +ATOM 13918 CD GLU I 108 58.958 44.630 142.927 1.00 18.30 C +ATOM 13919 OE1 GLU I 108 58.583 45.623 142.266 1.00 16.76 O +ATOM 13920 OE2 GLU I 108 59.847 44.744 143.786 1.00 29.52 O +ATOM 13921 N PHE I 109 54.283 42.414 140.625 1.00 12.14 N +ATOM 13922 CA PHE I 109 53.185 42.790 139.756 1.00 9.35 C +ATOM 13923 C PHE I 109 52.398 43.786 140.582 1.00 10.11 C +ATOM 13924 O PHE I 109 51.982 43.456 141.683 1.00 9.65 O +ATOM 13925 CB PHE I 109 52.319 41.581 139.415 1.00 8.50 C +ATOM 13926 CG PHE I 109 51.560 41.724 138.121 1.00 11.79 C +ATOM 13927 CD1 PHE I 109 52.155 41.388 136.908 1.00 9.06 C +ATOM 13928 CD2 PHE I 109 50.249 42.179 138.112 1.00 8.50 C +ATOM 13929 CE1 PHE I 109 51.454 41.502 135.709 1.00 8.50 C +ATOM 13930 CE2 PHE I 109 49.549 42.291 136.917 1.00 8.50 C +ATOM 13931 CZ PHE I 109 50.159 41.949 135.713 1.00 8.50 C +ATOM 13932 N TRP I 110 52.294 45.023 140.097 1.00 10.24 N +ATOM 13933 CA TRP I 110 51.568 46.074 140.788 1.00 8.50 C +ATOM 13934 C TRP I 110 50.344 46.423 140.003 1.00 8.50 C +ATOM 13935 O TRP I 110 50.448 46.830 138.856 1.00 12.12 O +ATOM 13936 CB TRP I 110 52.418 47.324 140.877 1.00 8.50 C +ATOM 13937 CG TRP I 110 53.670 47.173 141.666 1.00 11.38 C +ATOM 13938 CD1 TRP I 110 54.769 46.460 141.323 1.00 9.72 C +ATOM 13939 CD2 TRP I 110 53.947 47.746 142.941 1.00 8.50 C +ATOM 13940 NE1 TRP I 110 55.719 46.548 142.304 1.00 8.50 N +ATOM 13941 CE2 TRP I 110 55.239 47.328 143.313 1.00 8.50 C +ATOM 13942 CE3 TRP I 110 53.223 48.572 143.811 1.00 8.50 C +ATOM 13943 CZ2 TRP I 110 55.829 47.697 144.515 1.00 9.47 C +ATOM 13944 CZ3 TRP I 110 53.813 48.945 145.017 1.00 17.24 C +ATOM 13945 CH2 TRP I 110 55.107 48.503 145.357 1.00 12.31 C +ATOM 13946 N VAL I 111 49.182 46.283 140.612 1.00 8.50 N +ATOM 13947 CA VAL I 111 47.944 46.624 139.932 1.00 8.50 C +ATOM 13948 C VAL I 111 47.352 47.845 140.625 1.00 13.48 C +ATOM 13949 O VAL I 111 47.093 47.813 141.827 1.00 17.29 O +ATOM 13950 CB VAL I 111 46.941 45.480 139.984 1.00 8.50 C +ATOM 13951 CG1 VAL I 111 45.677 45.876 139.244 1.00 10.92 C +ATOM 13952 CG2 VAL I 111 47.540 44.251 139.353 1.00 12.67 C +ATOM 13953 N ASP I 112 47.184 48.926 139.870 1.00 11.82 N +ATOM 13954 CA ASP I 112 46.642 50.177 140.379 1.00 8.50 C +ATOM 13955 C ASP I 112 47.405 50.754 141.571 1.00 8.56 C +ATOM 13956 O ASP I 112 46.810 51.256 142.519 1.00 11.96 O +ATOM 13957 CB ASP I 112 45.149 50.041 140.693 1.00 8.50 C +ATOM 13958 CG ASP I 112 44.276 50.194 139.464 1.00 8.50 C +ATOM 13959 OD1 ASP I 112 44.680 50.903 138.520 1.00 8.50 O +ATOM 13960 OD2 ASP I 112 43.173 49.612 139.444 1.00 16.73 O +ATOM 13961 N GLY I 113 48.729 50.690 141.512 1.00 9.04 N +ATOM 13962 CA GLY I 113 49.542 51.243 142.581 1.00 10.30 C +ATOM 13963 C GLY I 113 49.734 50.376 143.808 1.00 14.82 C +ATOM 13964 O GLY I 113 50.523 50.723 144.695 1.00 18.07 O +ATOM 13965 N LYS I 114 49.011 49.258 143.867 1.00 13.14 N +ATOM 13966 CA LYS I 114 49.090 48.316 144.972 1.00 8.50 C +ATOM 13967 C LYS I 114 49.790 47.048 144.509 1.00 8.50 C +ATOM 13968 O LYS I 114 49.422 46.463 143.492 1.00 9.59 O +ATOM 13969 CB LYS I 114 47.682 47.963 145.435 1.00 8.50 C +ATOM 13970 CG LYS I 114 46.866 49.173 145.854 1.00 28.20 C +ATOM 13971 CD LYS I 114 46.044 48.879 147.093 1.00 38.45 C +ATOM 13972 CE LYS I 114 46.039 50.071 148.046 1.00 45.90 C +ATOM 13973 NZ LYS I 114 45.489 49.704 149.381 1.00 44.35 N +ATOM 13974 N PRO I 115 50.811 46.599 145.257 1.00 11.16 N +ATOM 13975 CA PRO I 115 51.603 45.404 144.964 1.00 8.50 C +ATOM 13976 C PRO I 115 50.987 44.073 145.320 1.00 8.50 C +ATOM 13977 O PRO I 115 50.320 43.936 146.340 1.00 10.35 O +ATOM 13978 CB PRO I 115 52.842 45.613 145.811 1.00 8.50 C +ATOM 13979 CG PRO I 115 52.261 46.160 147.046 1.00 9.34 C +ATOM 13980 CD PRO I 115 51.265 47.198 146.526 1.00 20.72 C +ATOM 13981 N ARG I 116 51.224 43.098 144.452 1.00 10.19 N +ATOM 13982 CA ARG I 116 50.786 41.730 144.657 1.00 9.93 C +ATOM 13983 C ARG I 116 52.059 41.140 145.263 1.00 13.23 C +ATOM 13984 O ARG I 116 53.123 41.772 145.204 1.00 13.72 O +ATOM 13985 CB ARG I 116 50.494 41.054 143.328 1.00 8.50 C +ATOM 13986 CG ARG I 116 49.477 41.758 142.489 1.00 8.78 C +ATOM 13987 CD ARG I 116 48.070 41.558 143.021 1.00 29.36 C +ATOM 13988 NE ARG I 116 47.539 40.243 142.688 1.00 30.47 N +ATOM 13989 CZ ARG I 116 47.535 39.217 143.523 1.00 37.35 C +ATOM 13990 NH1 ARG I 116 48.031 39.351 144.746 1.00 39.40 N +ATOM 13991 NH2 ARG I 116 47.052 38.051 143.128 1.00 43.78 N +ATOM 13992 N VAL I 117 51.975 39.937 145.823 1.00 14.26 N +ATOM 13993 CA VAL I 117 53.152 39.328 146.436 1.00 12.05 C +ATOM 13994 C VAL I 117 54.264 39.090 145.419 1.00 15.66 C +ATOM 13995 O VAL I 117 54.016 39.095 144.213 1.00 18.81 O +ATOM 13996 CB VAL I 117 52.826 37.992 147.115 1.00 8.50 C +ATOM 13997 CG1 VAL I 117 53.859 37.731 148.197 1.00 19.50 C +ATOM 13998 CG2 VAL I 117 51.426 38.005 147.700 1.00 8.50 C +ATOM 13999 N ARG I 118 55.493 38.927 145.906 1.00 14.71 N +ATOM 14000 CA ARG I 118 56.631 38.682 145.029 1.00 10.44 C +ATOM 14001 C ARG I 118 56.740 37.207 144.713 1.00 9.39 C +ATOM 14002 O ARG I 118 56.609 36.379 145.600 1.00 18.88 O +ATOM 14003 CB ARG I 118 57.927 39.130 145.680 1.00 8.50 C +ATOM 14004 CG ARG I 118 57.967 40.584 146.039 1.00 11.57 C +ATOM 14005 CD ARG I 118 59.401 40.993 146.332 1.00 12.03 C +ATOM 14006 NE ARG I 118 59.499 41.966 147.415 1.00 17.57 N +ATOM 14007 CZ ARG I 118 59.835 43.233 147.252 1.00 8.51 C +ATOM 14008 NH1 ARG I 118 60.109 43.697 146.055 1.00 8.50 N +ATOM 14009 NH2 ARG I 118 59.891 44.031 148.292 1.00 15.91 N +ATOM 14010 N LYS I 119 57.009 36.880 143.459 1.00 8.50 N +ATOM 14011 CA LYS I 119 57.137 35.496 143.040 1.00 8.60 C +ATOM 14012 C LYS I 119 58.467 35.268 142.333 1.00 9.56 C +ATOM 14013 O LYS I 119 59.152 36.227 142.005 1.00 16.12 O +ATOM 14014 CB LYS I 119 55.957 35.117 142.159 1.00 8.50 C +ATOM 14015 CG LYS I 119 54.652 35.142 142.912 1.00 8.50 C +ATOM 14016 CD LYS I 119 53.498 34.615 142.093 1.00 11.16 C +ATOM 14017 CE LYS I 119 52.268 34.421 142.968 1.00 17.35 C +ATOM 14018 NZ LYS I 119 51.068 33.943 142.220 1.00 26.37 N +ATOM 14019 N SER I 120 58.865 34.012 142.157 1.00 9.64 N +ATOM 14020 CA SER I 120 60.127 33.699 141.491 1.00 9.31 C +ATOM 14021 C SER I 120 59.846 33.177 140.094 1.00 9.18 C +ATOM 14022 O SER I 120 58.914 32.400 139.897 1.00 14.52 O +ATOM 14023 CB SER I 120 60.908 32.649 142.287 1.00 9.97 C +ATOM 14024 OG SER I 120 62.294 32.608 141.941 1.00 9.31 O +ATOM 14025 N LEU I 121 60.651 33.593 139.124 1.00 8.50 N +ATOM 14026 CA LEU I 121 60.477 33.152 137.745 1.00 11.42 C +ATOM 14027 C LEU I 121 61.706 33.433 136.877 1.00 17.97 C +ATOM 14028 O LEU I 121 62.231 34.539 136.864 1.00 16.63 O +ATOM 14029 CB LEU I 121 59.233 33.788 137.133 1.00 8.50 C +ATOM 14030 CG LEU I 121 59.028 33.721 135.620 1.00 8.50 C +ATOM 14031 CD1 LEU I 121 58.954 32.321 135.176 1.00 8.50 C +ATOM 14032 CD2 LEU I 121 57.761 34.443 135.244 1.00 11.21 C +ATOM 14033 N LYS I 122 62.180 32.390 136.197 1.00 21.62 N +ATOM 14034 CA LYS I 122 63.326 32.456 135.297 1.00 13.74 C +ATOM 14035 C LYS I 122 64.601 33.067 135.846 1.00 14.54 C +ATOM 14036 O LYS I 122 65.220 33.904 135.188 1.00 15.61 O +ATOM 14037 CB LYS I 122 62.934 33.147 133.987 1.00 9.62 C +ATOM 14038 CG LYS I 122 62.226 32.240 133.001 1.00 11.42 C +ATOM 14039 CD LYS I 122 63.184 31.216 132.429 1.00 26.52 C +ATOM 14040 CE LYS I 122 62.502 30.319 131.404 1.00 32.11 C +ATOM 14041 NZ LYS I 122 63.445 29.349 130.765 1.00 46.56 N +ATOM 14042 N LYS I 123 65.029 32.623 137.019 1.00 13.51 N +ATOM 14043 CA LYS I 123 66.264 33.153 137.598 1.00 15.99 C +ATOM 14044 C LYS I 123 67.450 32.810 136.703 1.00 17.38 C +ATOM 14045 O LYS I 123 67.492 31.738 136.115 1.00 29.27 O +ATOM 14046 CB LYS I 123 66.522 32.572 138.988 1.00 17.38 C +ATOM 14047 CG LYS I 123 67.820 33.091 139.600 1.00 19.23 C +ATOM 14048 CD LYS I 123 68.447 32.140 140.603 1.00 17.57 C +ATOM 14049 CE LYS I 123 67.790 32.226 141.937 1.00 11.55 C +ATOM 14050 NZ LYS I 123 68.631 31.527 142.939 1.00 17.00 N +ATOM 14051 N GLY I 124 68.403 33.717 136.594 1.00 16.56 N +ATOM 14052 CA GLY I 124 69.566 33.470 135.766 1.00 19.11 C +ATOM 14053 C GLY I 124 69.344 33.647 134.269 1.00 22.06 C +ATOM 14054 O GLY I 124 70.318 33.733 133.504 1.00 27.57 O +ATOM 14055 N TYR I 125 68.083 33.705 133.838 1.00 16.20 N +ATOM 14056 CA TYR I 125 67.779 33.872 132.422 1.00 18.56 C +ATOM 14057 C TYR I 125 68.256 35.244 131.968 1.00 21.16 C +ATOM 14058 O TYR I 125 68.683 36.068 132.780 1.00 23.55 O +ATOM 14059 CB TYR I 125 66.268 33.735 132.176 1.00 19.41 C +ATOM 14060 CG TYR I 125 65.848 33.706 130.705 1.00 21.57 C +ATOM 14061 CD1 TYR I 125 65.933 32.541 129.951 1.00 31.75 C +ATOM 14062 CD2 TYR I 125 65.348 34.831 130.083 1.00 26.63 C +ATOM 14063 CE1 TYR I 125 65.526 32.501 128.625 1.00 27.37 C +ATOM 14064 CE2 TYR I 125 64.944 34.800 128.758 1.00 28.79 C +ATOM 14065 CZ TYR I 125 65.034 33.630 128.035 1.00 25.54 C +ATOM 14066 OH TYR I 125 64.630 33.582 126.715 1.00 30.90 O +ATOM 14067 N THR I 126 68.209 35.480 130.664 1.00 22.54 N +ATOM 14068 CA THR I 126 68.606 36.766 130.107 1.00 24.23 C +ATOM 14069 C THR I 126 67.760 37.031 128.847 1.00 23.71 C +ATOM 14070 O THR I 126 67.732 36.216 127.931 1.00 24.46 O +ATOM 14071 CB THR I 126 70.141 36.825 129.872 1.00 13.73 C +ATOM 14072 OG1 THR I 126 70.455 37.838 128.925 1.00 10.79 O +ATOM 14073 CG2 THR I 126 70.682 35.486 129.402 1.00 29.25 C +ATOM 14074 N VAL I 127 66.984 38.116 128.877 1.00 21.70 N +ATOM 14075 CA VAL I 127 66.091 38.484 127.787 1.00 16.68 C +ATOM 14076 C VAL I 127 66.821 39.002 126.555 1.00 15.96 C +ATOM 14077 O VAL I 127 67.768 39.775 126.669 1.00 13.41 O +ATOM 14078 CB VAL I 127 65.041 39.503 128.272 1.00 16.20 C +ATOM 14079 CG1 VAL I 127 64.161 39.969 127.125 1.00 21.28 C +ATOM 14080 CG2 VAL I 127 64.182 38.874 129.339 1.00 16.02 C +ATOM 14081 N GLY I 128 66.360 38.567 125.383 1.00 16.62 N +ATOM 14082 CA GLY I 128 66.959 38.963 124.120 1.00 24.42 C +ATOM 14083 C GLY I 128 66.846 40.440 123.816 1.00 27.61 C +ATOM 14084 O GLY I 128 65.813 41.035 124.083 1.00 30.53 O +ATOM 14085 N ALA I 129 67.893 41.006 123.213 1.00 32.19 N +ATOM 14086 CA ALA I 129 67.959 42.432 122.882 1.00 34.13 C +ATOM 14087 C ALA I 129 67.232 42.884 121.608 1.00 41.42 C +ATOM 14088 O ALA I 129 66.707 44.006 121.556 1.00 42.41 O +ATOM 14089 CB ALA I 129 69.405 42.887 122.839 1.00 33.54 C +ATOM 14090 N GLU I 130 67.268 42.065 120.557 1.00 45.74 N +ATOM 14091 CA GLU I 130 66.584 42.429 119.317 1.00 49.53 C +ATOM 14092 C GLU I 130 65.214 41.786 119.353 1.00 44.16 C +ATOM 14093 O GLU I 130 65.088 40.563 119.270 1.00 43.77 O +ATOM 14094 CB GLU I 130 67.378 41.994 118.082 1.00 63.32 C +ATOM 14095 CG GLU I 130 67.754 40.520 118.043 1.00 91.11 C +ATOM 14096 CD GLU I 130 68.532 40.160 116.792 1.00101.49 C +ATOM 14097 OE1 GLU I 130 69.776 40.285 116.811 1.00104.39 O +ATOM 14098 OE2 GLU I 130 67.898 39.761 115.789 1.00108.67 O +ATOM 14099 N ALA I 131 64.185 42.617 119.481 1.00 41.30 N +ATOM 14100 CA ALA I 131 62.832 42.105 119.591 1.00 32.89 C +ATOM 14101 C ALA I 131 61.758 42.896 118.890 1.00 21.59 C +ATOM 14102 O ALA I 131 61.931 44.062 118.580 1.00 26.98 O +ATOM 14103 CB ALA I 131 62.466 41.964 121.066 1.00 38.10 C +ATOM 14104 N SER I 132 60.645 42.222 118.653 1.00 15.02 N +ATOM 14105 CA SER I 132 59.471 42.799 118.034 1.00 19.95 C +ATOM 14106 C SER I 132 58.495 42.974 119.198 1.00 22.88 C +ATOM 14107 O SER I 132 58.100 41.993 119.830 1.00 22.72 O +ATOM 14108 CB SER I 132 58.885 41.844 116.992 1.00 9.63 C +ATOM 14109 OG SER I 132 57.701 42.365 116.420 1.00 15.90 O +ATOM 14110 N ILE I 133 58.173 44.226 119.511 1.00 18.98 N +ATOM 14111 CA ILE I 133 57.261 44.568 120.591 1.00 12.05 C +ATOM 14112 C ILE I 133 55.925 45.006 119.987 1.00 11.35 C +ATOM 14113 O ILE I 133 55.844 46.011 119.307 1.00 16.34 O +ATOM 14114 CB ILE I 133 57.846 45.702 121.431 1.00 8.50 C +ATOM 14115 CG1 ILE I 133 59.254 45.345 121.888 1.00 8.50 C +ATOM 14116 CG2 ILE I 133 56.965 45.981 122.612 1.00 15.62 C +ATOM 14117 CD1 ILE I 133 59.955 46.449 122.626 1.00 8.50 C +ATOM 14118 N ILE I 134 54.869 44.264 120.254 1.00 8.50 N +ATOM 14119 CA ILE I 134 53.589 44.592 119.683 1.00 8.50 C +ATOM 14120 C ILE I 134 52.483 44.796 120.689 1.00 10.42 C +ATOM 14121 O ILE I 134 52.396 44.114 121.697 1.00 12.76 O +ATOM 14122 CB ILE I 134 53.196 43.553 118.604 1.00 8.50 C +ATOM 14123 CG1 ILE I 134 54.023 43.806 117.343 1.00 8.50 C +ATOM 14124 CG2 ILE I 134 51.689 43.543 118.340 1.00 8.50 C +ATOM 14125 CD1 ILE I 134 53.734 42.873 116.225 1.00 23.82 C +ATOM 14126 N LEU I 135 51.634 45.764 120.385 1.00 9.48 N +ATOM 14127 CA LEU I 135 50.512 46.124 121.219 1.00 8.67 C +ATOM 14128 C LEU I 135 49.223 45.715 120.536 1.00 9.44 C +ATOM 14129 O LEU I 135 49.060 45.931 119.351 1.00 8.50 O +ATOM 14130 CB LEU I 135 50.513 47.640 121.439 1.00 8.50 C +ATOM 14131 CG LEU I 135 51.095 48.259 122.706 1.00 8.50 C +ATOM 14132 CD1 LEU I 135 52.309 47.511 123.168 1.00 8.50 C +ATOM 14133 CD2 LEU I 135 51.423 49.714 122.441 1.00 8.50 C +ATOM 14134 N GLY I 136 48.329 45.083 121.277 1.00 14.93 N +ATOM 14135 CA GLY I 136 47.048 44.701 120.713 1.00 19.13 C +ATOM 14136 C GLY I 136 46.881 43.340 120.086 1.00 22.91 C +ATOM 14137 O GLY I 136 45.755 42.933 119.839 1.00 19.10 O +ATOM 14138 N GLN I 137 47.984 42.657 119.781 1.00 26.99 N +ATOM 14139 CA GLN I 137 47.940 41.320 119.173 1.00 16.90 C +ATOM 14140 C GLN I 137 48.856 40.377 119.898 1.00 16.55 C +ATOM 14141 O GLN I 137 49.793 40.813 120.578 1.00 19.64 O +ATOM 14142 CB GLN I 137 48.353 41.360 117.701 1.00 17.76 C +ATOM 14143 CG GLN I 137 47.243 41.803 116.750 1.00 22.96 C +ATOM 14144 CD GLN I 137 45.967 40.988 116.886 1.00 16.17 C +ATOM 14145 OE1 GLN I 137 44.894 41.433 116.486 1.00 12.24 O +ATOM 14146 NE2 GLN I 137 46.081 39.786 117.439 1.00 11.41 N +ATOM 14147 N GLU I 138 48.598 39.083 119.751 1.00 14.64 N +ATOM 14148 CA GLU I 138 49.437 38.089 120.404 1.00 18.77 C +ATOM 14149 C GLU I 138 50.428 37.462 119.429 1.00 20.46 C +ATOM 14150 O GLU I 138 50.044 36.739 118.517 1.00 24.35 O +ATOM 14151 CB GLU I 138 48.579 37.009 121.044 1.00 22.35 C +ATOM 14152 CG GLU I 138 49.241 36.314 122.236 1.00 26.17 C +ATOM 14153 CD GLU I 138 50.415 35.408 121.861 1.00 34.03 C +ATOM 14154 OE1 GLU I 138 50.187 34.237 121.485 1.00 41.77 O +ATOM 14155 OE2 GLU I 138 51.569 35.854 121.975 1.00 26.85 O +ATOM 14156 N GLN I 139 51.706 37.756 119.619 1.00 23.04 N +ATOM 14157 CA GLN I 139 52.753 37.214 118.753 1.00 26.30 C +ATOM 14158 C GLN I 139 53.074 35.730 118.991 1.00 36.69 C +ATOM 14159 O GLN I 139 53.238 35.256 120.141 1.00 37.76 O +ATOM 14160 CB GLN I 139 54.035 38.029 118.901 1.00 22.82 C +ATOM 14161 CG GLN I 139 54.226 39.134 117.892 1.00 12.34 C +ATOM 14162 CD GLN I 139 55.252 40.141 118.357 1.00 12.22 C +ATOM 14163 OE1 GLN I 139 54.909 41.090 119.020 1.00 35.06 O +ATOM 14164 NE2 GLN I 139 56.508 39.924 118.040 1.00 8.50 N +ATOM 14165 N ASP I 140 53.167 34.999 117.888 1.00 38.99 N +ATOM 14166 CA ASP I 140 53.483 33.586 117.931 1.00 42.66 C +ATOM 14167 C ASP I 140 54.618 33.313 116.966 1.00 43.22 C +ATOM 14168 O ASP I 140 54.966 32.169 116.694 1.00 54.35 O +ATOM 14169 CB ASP I 140 52.240 32.745 117.630 1.00 39.97 C +ATOM 14170 CG ASP I 140 51.259 32.740 118.791 1.00 41.74 C +ATOM 14171 OD1 ASP I 140 51.730 32.726 119.955 1.00 31.44 O +ATOM 14172 OD2 ASP I 140 50.036 32.781 118.540 1.00 33.54 O +ATOM 14173 N SER I 141 55.196 34.394 116.462 1.00 40.09 N +ATOM 14174 CA SER I 141 56.335 34.362 115.557 1.00 38.97 C +ATOM 14175 C SER I 141 56.830 35.792 115.526 1.00 34.30 C +ATOM 14176 O SER I 141 56.055 36.714 115.734 1.00 39.67 O +ATOM 14177 CB SER I 141 55.928 33.923 114.153 1.00 40.69 C +ATOM 14178 OG SER I 141 55.362 34.979 113.400 1.00 42.07 O +ATOM 14179 N PHE I 142 58.113 35.986 115.287 1.00 30.22 N +ATOM 14180 CA PHE I 142 58.674 37.330 115.260 1.00 29.70 C +ATOM 14181 C PHE I 142 57.891 38.274 114.366 1.00 32.40 C +ATOM 14182 O PHE I 142 57.991 38.214 113.156 1.00 38.39 O +ATOM 14183 CB PHE I 142 60.111 37.281 114.793 1.00 26.62 C +ATOM 14184 CG PHE I 142 60.873 38.533 115.041 1.00 13.07 C +ATOM 14185 CD1 PHE I 142 61.514 38.740 116.243 1.00 28.91 C +ATOM 14186 CD2 PHE I 142 61.035 39.461 114.040 1.00 36.71 C +ATOM 14187 CE1 PHE I 142 62.321 39.855 116.446 1.00 37.16 C +ATOM 14188 CE2 PHE I 142 61.838 40.583 114.225 1.00 43.54 C +ATOM 14189 CZ PHE I 142 62.484 40.774 115.436 1.00 44.43 C +ATOM 14190 N GLY I 143 57.079 39.120 114.984 1.00 35.77 N +ATOM 14191 CA GLY I 143 56.297 40.095 114.255 1.00 29.27 C +ATOM 14192 C GLY I 143 55.052 39.596 113.569 1.00 31.40 C +ATOM 14193 O GLY I 143 54.474 40.330 112.775 1.00 34.65 O +ATOM 14194 N GLY I 144 54.605 38.386 113.892 1.00 33.06 N +ATOM 14195 CA GLY I 144 53.417 37.854 113.246 1.00 37.73 C +ATOM 14196 C GLY I 144 52.744 36.666 113.902 1.00 38.09 C +ATOM 14197 O GLY I 144 52.985 36.363 115.067 1.00 40.25 O +ATOM 14198 N ASN I 145 51.895 35.993 113.126 1.00 44.17 N +ATOM 14199 CA ASN I 145 51.130 34.829 113.573 1.00 48.51 C +ATOM 14200 C ASN I 145 50.159 35.233 114.667 1.00 43.88 C +ATOM 14201 O ASN I 145 50.174 34.700 115.774 1.00 44.54 O +ATOM 14202 CB ASN I 145 52.050 33.694 114.041 1.00 59.00 C +ATOM 14203 CG ASN I 145 52.600 32.868 112.882 1.00 63.50 C +ATOM 14204 OD1 ASN I 145 53.316 33.378 112.010 1.00 66.12 O +ATOM 14205 ND2 ASN I 145 52.281 31.583 112.880 1.00 63.62 N +ATOM 14206 N PHE I 146 49.280 36.159 114.316 1.00 38.01 N +ATOM 14207 CA PHE I 146 48.304 36.685 115.246 1.00 37.46 C +ATOM 14208 C PHE I 146 47.015 35.874 115.338 1.00 42.42 C +ATOM 14209 O PHE I 146 46.355 35.614 114.334 1.00 45.69 O +ATOM 14210 CB PHE I 146 47.958 38.129 114.870 1.00 22.54 C +ATOM 14211 CG PHE I 146 49.142 39.022 114.743 1.00 8.50 C +ATOM 14212 CD1 PHE I 146 50.187 38.934 115.638 1.00 8.50 C +ATOM 14213 CD2 PHE I 146 49.217 39.948 113.718 1.00 8.50 C +ATOM 14214 CE1 PHE I 146 51.300 39.759 115.520 1.00 12.43 C +ATOM 14215 CE2 PHE I 146 50.323 40.773 113.588 1.00 8.50 C +ATOM 14216 CZ PHE I 146 51.367 40.678 114.493 1.00 12.16 C +ATOM 14217 N GLU I 147 46.657 35.487 116.556 1.00 44.78 N +ATOM 14218 CA GLU I 147 45.427 34.756 116.820 1.00 46.57 C +ATOM 14219 C GLU I 147 44.397 35.798 117.232 1.00 44.81 C +ATOM 14220 O GLU I 147 44.587 36.466 118.244 1.00 44.03 O +ATOM 14221 CB GLU I 147 45.651 33.817 118.000 1.00 51.82 C +ATOM 14222 CG GLU I 147 45.794 32.338 117.661 1.00 57.30 C +ATOM 14223 CD GLU I 147 46.323 31.533 118.841 1.00 59.08 C +ATOM 14224 OE1 GLU I 147 47.522 31.683 119.161 1.00 62.86 O +ATOM 14225 OE2 GLU I 147 45.550 30.766 119.459 1.00 55.33 O +ATOM 14226 N GLY I 148 43.322 35.925 116.452 1.00 47.37 N +ATOM 14227 CA GLY I 148 42.265 36.889 116.726 1.00 44.98 C +ATOM 14228 C GLY I 148 41.521 36.680 118.023 1.00 43.35 C +ATOM 14229 O GLY I 148 40.850 37.587 118.514 1.00 48.87 O +ATOM 14230 N SER I 149 41.661 35.484 118.583 1.00 40.75 N +ATOM 14231 CA SER I 149 41.029 35.116 119.843 1.00 39.71 C +ATOM 14232 C SER I 149 41.813 35.694 121.025 1.00 34.90 C +ATOM 14233 O SER I 149 41.427 35.543 122.174 1.00 43.76 O +ATOM 14234 CB SER I 149 40.968 33.589 119.935 1.00 39.89 C +ATOM 14235 OG SER I 149 40.234 33.144 121.063 1.00 61.11 O +ATOM 14236 N GLN I 150 42.913 36.369 120.731 1.00 26.85 N +ATOM 14237 CA GLN I 150 43.766 36.960 121.751 1.00 18.99 C +ATOM 14238 C GLN I 150 44.077 38.430 121.427 1.00 24.03 C +ATOM 14239 O GLN I 150 45.046 38.999 121.906 1.00 27.39 O +ATOM 14240 CB GLN I 150 45.063 36.153 121.832 1.00 19.72 C +ATOM 14241 CG GLN I 150 44.838 34.643 121.894 1.00 25.97 C +ATOM 14242 CD GLN I 150 46.087 33.843 122.223 1.00 23.09 C +ATOM 14243 OE1 GLN I 150 47.106 33.936 121.541 1.00 13.31 O +ATOM 14244 NE2 GLN I 150 45.996 33.026 123.263 1.00 30.82 N +ATOM 14245 N SER I 151 43.250 39.037 120.594 1.00 26.28 N +ATOM 14246 CA SER I 151 43.440 40.412 120.207 1.00 21.01 C +ATOM 14247 C SER I 151 42.870 41.285 121.297 1.00 19.73 C +ATOM 14248 O SER I 151 42.042 40.835 122.075 1.00 22.76 O +ATOM 14249 CB SER I 151 42.702 40.679 118.888 1.00 24.17 C +ATOM 14250 OG SER I 151 42.938 42.008 118.437 1.00 61.54 O +ATOM 14251 N LEU I 152 43.308 42.538 121.364 1.00 21.46 N +ATOM 14252 CA LEU I 152 42.770 43.447 122.364 1.00 13.91 C +ATOM 14253 C LEU I 152 41.738 44.388 121.754 1.00 8.50 C +ATOM 14254 O LEU I 152 41.955 44.953 120.695 1.00 9.10 O +ATOM 14255 CB LEU I 152 43.886 44.265 123.011 1.00 8.50 C +ATOM 14256 CG LEU I 152 43.422 45.383 123.942 1.00 8.50 C +ATOM 14257 CD1 LEU I 152 43.023 44.851 125.309 1.00 10.85 C +ATOM 14258 CD2 LEU I 152 44.526 46.360 124.091 1.00 8.50 C +ATOM 14259 N VAL I 153 40.607 44.529 122.420 1.00 8.50 N +ATOM 14260 CA VAL I 153 39.570 45.422 121.960 1.00 9.15 C +ATOM 14261 C VAL I 153 39.327 46.416 123.091 1.00 13.86 C +ATOM 14262 O VAL I 153 38.800 46.047 124.148 1.00 8.50 O +ATOM 14263 CB VAL I 153 38.271 44.685 121.645 1.00 8.50 C +ATOM 14264 CG1 VAL I 153 37.320 45.602 120.904 1.00 8.50 C +ATOM 14265 CG2 VAL I 153 38.559 43.455 120.830 1.00 9.98 C +ATOM 14266 N GLY I 154 39.767 47.657 122.866 1.00 13.17 N +ATOM 14267 CA GLY I 154 39.629 48.717 123.843 1.00 9.54 C +ATOM 14268 C GLY I 154 40.760 49.706 123.675 1.00 11.96 C +ATOM 14269 O GLY I 154 41.303 49.834 122.579 1.00 11.51 O +ATOM 14270 N ASP I 155 41.142 50.381 124.754 1.00 9.53 N +ATOM 14271 CA ASP I 155 42.210 51.365 124.698 1.00 8.50 C +ATOM 14272 C ASP I 155 43.428 50.894 125.454 1.00 8.50 C +ATOM 14273 O ASP I 155 43.310 50.172 126.435 1.00 8.50 O +ATOM 14274 CB ASP I 155 41.758 52.670 125.349 1.00 8.50 C +ATOM 14275 CG ASP I 155 40.693 53.380 124.575 1.00 8.50 C +ATOM 14276 OD1 ASP I 155 39.615 52.777 124.327 1.00 8.50 O +ATOM 14277 OD2 ASP I 155 40.937 54.568 124.258 1.00 11.05 O +ATOM 14278 N ILE I 156 44.593 51.340 125.017 1.00 8.50 N +ATOM 14279 CA ILE I 156 45.834 51.020 125.689 1.00 8.50 C +ATOM 14280 C ILE I 156 46.728 52.222 125.511 1.00 8.50 C +ATOM 14281 O ILE I 156 46.747 52.831 124.452 1.00 14.83 O +ATOM 14282 CB ILE I 156 46.506 49.770 125.127 1.00 8.50 C +ATOM 14283 CG1 ILE I 156 47.767 49.470 125.924 1.00 8.50 C +ATOM 14284 CG2 ILE I 156 46.838 49.949 123.682 1.00 8.50 C +ATOM 14285 CD1 ILE I 156 48.433 48.205 125.531 1.00 17.57 C +ATOM 14286 N GLY I 157 47.420 52.608 126.566 1.00 8.50 N +ATOM 14287 CA GLY I 157 48.286 53.761 126.478 1.00 9.43 C +ATOM 14288 C GLY I 157 49.254 53.823 127.636 1.00 9.47 C +ATOM 14289 O GLY I 157 49.310 52.933 128.470 1.00 8.50 O +ATOM 14290 N ASN I 158 50.009 54.904 127.687 1.00 13.40 N +ATOM 14291 CA ASN I 158 51.009 55.124 128.717 1.00 8.50 C +ATOM 14292 C ASN I 158 51.967 53.987 128.935 1.00 8.50 C +ATOM 14293 O ASN I 158 52.299 53.681 130.059 1.00 10.69 O +ATOM 14294 CB ASN I 158 50.369 55.518 130.036 1.00 13.89 C +ATOM 14295 CG ASN I 158 50.096 57.005 130.126 1.00 22.91 C +ATOM 14296 OD1 ASN I 158 48.961 57.424 130.379 1.00 23.94 O +ATOM 14297 ND2 ASN I 158 51.135 57.815 129.920 1.00 23.15 N +ATOM 14298 N VAL I 159 52.425 53.369 127.857 1.00 9.87 N +ATOM 14299 CA VAL I 159 53.369 52.273 127.982 1.00 10.20 C +ATOM 14300 C VAL I 159 54.781 52.840 128.069 1.00 8.50 C +ATOM 14301 O VAL I 159 55.154 53.724 127.307 1.00 10.68 O +ATOM 14302 CB VAL I 159 53.206 51.183 126.855 1.00 8.50 C +ATOM 14303 CG1 VAL I 159 52.216 51.612 125.799 1.00 8.50 C +ATOM 14304 CG2 VAL I 159 54.538 50.828 126.241 1.00 9.02 C +ATOM 14305 N ASN I 160 55.521 52.388 129.071 1.00 8.50 N +ATOM 14306 CA ASN I 160 56.894 52.813 129.298 1.00 11.42 C +ATOM 14307 C ASN I 160 57.662 51.576 129.751 1.00 12.64 C +ATOM 14308 O ASN I 160 57.057 50.654 130.302 1.00 15.37 O +ATOM 14309 CB ASN I 160 56.950 53.883 130.391 1.00 13.38 C +ATOM 14310 CG ASN I 160 56.241 55.156 130.000 1.00 9.70 C +ATOM 14311 OD1 ASN I 160 55.096 55.368 130.366 1.00 18.67 O +ATOM 14312 ND2 ASN I 160 56.924 56.016 129.259 1.00 15.57 N +ATOM 14313 N MET I 161 58.979 51.560 129.553 1.00 8.50 N +ATOM 14314 CA MET I 161 59.784 50.417 129.935 1.00 8.50 C +ATOM 14315 C MET I 161 61.174 50.844 130.341 1.00 8.50 C +ATOM 14316 O MET I 161 61.782 51.687 129.693 1.00 12.03 O +ATOM 14317 CB MET I 161 59.848 49.435 128.776 1.00 8.50 C +ATOM 14318 CG MET I 161 60.627 48.158 129.047 1.00 17.83 C +ATOM 14319 SD MET I 161 60.476 46.963 127.715 1.00 17.68 S +ATOM 14320 CE MET I 161 61.164 45.525 128.411 1.00 8.50 C +ATOM 14321 N TRP I 162 61.655 50.280 131.440 1.00 11.95 N +ATOM 14322 CA TRP I 162 62.984 50.576 131.963 1.00 13.95 C +ATOM 14323 C TRP I 162 63.792 49.279 131.891 1.00 13.50 C +ATOM 14324 O TRP I 162 63.214 48.191 131.882 1.00 12.98 O +ATOM 14325 CB TRP I 162 62.897 51.031 133.430 1.00 12.59 C +ATOM 14326 CG TRP I 162 62.175 52.311 133.673 1.00 8.50 C +ATOM 14327 CD1 TRP I 162 62.734 53.508 133.989 1.00 9.24 C +ATOM 14328 CD2 TRP I 162 60.758 52.507 133.703 1.00 8.50 C +ATOM 14329 NE1 TRP I 162 61.754 54.431 134.227 1.00 8.50 N +ATOM 14330 CE2 TRP I 162 60.530 53.837 134.062 1.00 8.50 C +ATOM 14331 CE3 TRP I 162 59.659 51.681 133.467 1.00 10.56 C +ATOM 14332 CZ2 TRP I 162 59.247 54.362 134.194 1.00 9.55 C +ATOM 14333 CZ3 TRP I 162 58.383 52.207 133.594 1.00 8.50 C +ATOM 14334 CH2 TRP I 162 58.193 53.530 133.955 1.00 8.50 C +ATOM 14335 N ASP I 163 65.118 49.393 131.846 1.00 11.64 N +ATOM 14336 CA ASP I 163 65.971 48.214 131.805 1.00 12.07 C +ATOM 14337 C ASP I 163 66.429 47.778 133.203 1.00 14.02 C +ATOM 14338 O ASP I 163 67.329 46.943 133.347 1.00 15.89 O +ATOM 14339 CB ASP I 163 67.170 48.419 130.860 1.00 17.46 C +ATOM 14340 CG ASP I 163 68.166 49.486 131.346 1.00 28.46 C +ATOM 14341 OD1 ASP I 163 68.272 49.773 132.567 1.00 23.09 O +ATOM 14342 OD2 ASP I 163 68.888 50.020 130.475 1.00 37.11 O +ATOM 14343 N PHE I 164 65.836 48.389 134.225 1.00 10.97 N +ATOM 14344 CA PHE I 164 66.138 48.073 135.609 1.00 11.03 C +ATOM 14345 C PHE I 164 64.840 47.974 136.386 1.00 8.50 C +ATOM 14346 O PHE I 164 63.785 48.297 135.861 1.00 11.59 O +ATOM 14347 CB PHE I 164 67.085 49.104 136.224 1.00 15.96 C +ATOM 14348 CG PHE I 164 66.532 50.493 136.284 1.00 12.58 C +ATOM 14349 CD1 PHE I 164 66.675 51.356 135.208 1.00 14.45 C +ATOM 14350 CD2 PHE I 164 65.887 50.952 137.426 1.00 12.94 C +ATOM 14351 CE1 PHE I 164 66.183 52.656 135.263 1.00 11.21 C +ATOM 14352 CE2 PHE I 164 65.391 52.253 137.486 1.00 8.50 C +ATOM 14353 CZ PHE I 164 65.542 53.102 136.402 1.00 8.50 C +ATOM 14354 N VAL I 165 64.919 47.524 137.634 1.00 13.69 N +ATOM 14355 CA VAL I 165 63.722 47.355 138.472 1.00 13.39 C +ATOM 14356 C VAL I 165 63.349 48.593 139.295 1.00 9.75 C +ATOM 14357 O VAL I 165 64.100 49.030 140.166 1.00 11.65 O +ATOM 14358 CB VAL I 165 63.859 46.118 139.434 1.00 12.52 C +ATOM 14359 CG1 VAL I 165 62.558 45.873 140.170 1.00 22.25 C +ATOM 14360 CG2 VAL I 165 64.240 44.878 138.657 1.00 15.77 C +ATOM 14361 N LEU I 166 62.184 49.151 139.003 1.00 8.50 N +ATOM 14362 CA LEU I 166 61.694 50.315 139.720 1.00 8.81 C +ATOM 14363 C LEU I 166 61.411 49.970 141.175 1.00 9.60 C +ATOM 14364 O LEU I 166 60.976 48.849 141.498 1.00 12.74 O +ATOM 14365 CB LEU I 166 60.409 50.825 139.071 1.00 8.84 C +ATOM 14366 CG LEU I 166 60.494 52.044 138.170 1.00 9.29 C +ATOM 14367 CD1 LEU I 166 61.594 51.847 137.170 1.00 16.08 C +ATOM 14368 CD2 LEU I 166 59.161 52.253 137.477 1.00 14.82 C +ATOM 14369 N SER I 167 61.668 50.926 142.057 1.00 9.35 N +ATOM 14370 CA SER I 167 61.423 50.712 143.476 1.00 15.51 C +ATOM 14371 C SER I 167 59.969 51.024 143.772 1.00 11.77 C +ATOM 14372 O SER I 167 59.280 51.603 142.949 1.00 14.39 O +ATOM 14373 CB SER I 167 62.349 51.593 144.335 1.00 18.69 C +ATOM 14374 OG SER I 167 61.985 52.959 144.297 1.00 15.57 O +ATOM 14375 N PRO I 168 59.484 50.644 144.957 1.00 9.72 N +ATOM 14376 CA PRO I 168 58.097 50.909 145.331 1.00 10.52 C +ATOM 14377 C PRO I 168 57.747 52.394 145.254 1.00 15.43 C +ATOM 14378 O PRO I 168 56.648 52.760 144.843 1.00 21.12 O +ATOM 14379 CB PRO I 168 58.049 50.405 146.766 1.00 12.95 C +ATOM 14380 CG PRO I 168 58.984 49.261 146.742 1.00 13.46 C +ATOM 14381 CD PRO I 168 60.147 49.821 145.982 1.00 12.25 C +ATOM 14382 N ASP I 169 58.691 53.248 145.639 1.00 17.66 N +ATOM 14383 CA ASP I 169 58.471 54.693 145.616 1.00 16.24 C +ATOM 14384 C ASP I 169 58.386 55.213 144.197 1.00 14.02 C +ATOM 14385 O ASP I 169 57.542 56.043 143.891 1.00 16.38 O +ATOM 14386 CB ASP I 169 59.574 55.416 146.384 1.00 25.81 C +ATOM 14387 CG ASP I 169 59.643 54.995 147.854 1.00 37.88 C +ATOM 14388 OD1 ASP I 169 58.657 55.260 148.589 1.00 38.67 O +ATOM 14389 OD2 ASP I 169 60.680 54.402 148.267 1.00 43.90 O +ATOM 14390 N GLU I 170 59.242 54.695 143.324 1.00 11.19 N +ATOM 14391 CA GLU I 170 59.238 55.108 141.927 1.00 8.50 C +ATOM 14392 C GLU I 170 57.942 54.611 141.302 1.00 8.50 C +ATOM 14393 O GLU I 170 57.187 55.380 140.742 1.00 10.99 O +ATOM 14394 CB GLU I 170 60.457 54.543 141.190 1.00 8.50 C +ATOM 14395 CG GLU I 170 61.789 54.890 141.856 1.00 21.85 C +ATOM 14396 CD GLU I 170 63.005 54.385 141.096 1.00 31.25 C +ATOM 14397 OE1 GLU I 170 63.235 54.874 139.974 1.00 42.31 O +ATOM 14398 OE2 GLU I 170 63.740 53.518 141.624 1.00 32.19 O +ATOM 14399 N ILE I 171 57.636 53.334 141.486 1.00 12.51 N +ATOM 14400 CA ILE I 171 56.413 52.744 140.940 1.00 10.71 C +ATOM 14401 C ILE I 171 55.218 53.535 141.400 1.00 8.50 C +ATOM 14402 O ILE I 171 54.213 53.646 140.708 1.00 8.50 O +ATOM 14403 CB ILE I 171 56.254 51.271 141.356 1.00 8.50 C +ATOM 14404 CG1 ILE I 171 57.303 50.434 140.631 1.00 8.50 C +ATOM 14405 CG2 ILE I 171 54.863 50.784 141.035 1.00 8.50 C +ATOM 14406 CD1 ILE I 171 57.233 48.966 140.901 1.00 27.43 C +ATOM 14407 N ASN I 172 55.356 54.125 142.571 1.00 14.65 N +ATOM 14408 CA ASN I 172 54.282 54.912 143.108 1.00 19.36 C +ATOM 14409 C ASN I 172 54.145 56.229 142.381 1.00 15.17 C +ATOM 14410 O ASN I 172 53.055 56.570 141.952 1.00 18.70 O +ATOM 14411 CB ASN I 172 54.443 55.141 144.598 1.00 24.42 C +ATOM 14412 CG ASN I 172 53.235 55.815 145.186 1.00 40.36 C +ATOM 14413 OD1 ASN I 172 53.268 57.006 145.457 1.00 45.99 O +ATOM 14414 ND2 ASN I 172 52.135 55.070 145.336 1.00 41.23 N +ATOM 14415 N THR I 173 55.240 56.959 142.195 1.00 12.13 N +ATOM 14416 CA THR I 173 55.129 58.229 141.484 1.00 8.50 C +ATOM 14417 C THR I 173 54.648 57.988 140.059 1.00 8.50 C +ATOM 14418 O THR I 173 53.820 58.740 139.569 1.00 13.01 O +ATOM 14419 CB THR I 173 56.425 59.089 141.490 1.00 8.50 C +ATOM 14420 OG1 THR I 173 57.237 58.778 140.360 1.00 8.50 O +ATOM 14421 CG2 THR I 173 57.224 58.868 142.761 1.00 23.60 C +ATOM 14422 N ILE I 174 55.113 56.926 139.402 1.00 8.58 N +ATOM 14423 CA ILE I 174 54.653 56.647 138.042 1.00 8.50 C +ATOM 14424 C ILE I 174 53.133 56.577 138.064 1.00 8.50 C +ATOM 14425 O ILE I 174 52.470 57.187 137.244 1.00 8.50 O +ATOM 14426 CB ILE I 174 55.195 55.315 137.475 1.00 8.50 C +ATOM 14427 CG1 ILE I 174 56.607 55.471 136.938 1.00 8.50 C +ATOM 14428 CG2 ILE I 174 54.337 54.854 136.319 1.00 8.50 C +ATOM 14429 CD1 ILE I 174 57.650 55.521 137.969 1.00 9.29 C +ATOM 14430 N TYR I 175 52.587 55.856 139.032 1.00 8.50 N +ATOM 14431 CA TYR I 175 51.147 55.713 139.138 1.00 8.50 C +ATOM 14432 C TYR I 175 50.436 57.027 139.389 1.00 17.53 C +ATOM 14433 O TYR I 175 49.464 57.343 138.711 1.00 23.40 O +ATOM 14434 CB TYR I 175 50.776 54.737 140.245 1.00 8.50 C +ATOM 14435 CG TYR I 175 49.275 54.638 140.499 1.00 8.50 C +ATOM 14436 CD1 TYR I 175 48.395 54.386 139.466 1.00 8.99 C +ATOM 14437 CD2 TYR I 175 48.745 54.788 141.779 1.00 15.92 C +ATOM 14438 CE1 TYR I 175 47.030 54.282 139.686 1.00 8.50 C +ATOM 14439 CE2 TYR I 175 47.377 54.684 142.010 1.00 18.61 C +ATOM 14440 CZ TYR I 175 46.528 54.431 140.956 1.00 16.21 C +ATOM 14441 OH TYR I 175 45.171 54.324 141.169 1.00 30.66 O +ATOM 14442 N LEU I 176 50.911 57.764 140.391 1.00 22.65 N +ATOM 14443 CA LEU I 176 50.348 59.050 140.794 1.00 19.48 C +ATOM 14444 C LEU I 176 50.569 60.201 139.813 1.00 22.67 C +ATOM 14445 O LEU I 176 50.034 61.283 139.998 1.00 24.67 O +ATOM 14446 CB LEU I 176 50.900 59.425 142.162 1.00 16.65 C +ATOM 14447 CG LEU I 176 49.948 59.290 143.344 1.00 14.18 C +ATOM 14448 CD1 LEU I 176 48.818 58.335 143.029 1.00 11.64 C +ATOM 14449 CD2 LEU I 176 50.752 58.861 144.565 1.00 25.53 C +ATOM 14450 N GLY I 177 51.366 59.969 138.785 1.00 24.82 N +ATOM 14451 CA GLY I 177 51.610 61.004 137.811 1.00 31.83 C +ATOM 14452 C GLY I 177 52.718 61.932 138.239 1.00 35.77 C +ATOM 14453 O GLY I 177 52.529 63.120 138.416 1.00 45.09 O +ATOM 14454 N GLY I 178 53.878 61.372 138.500 1.00 38.89 N +ATOM 14455 CA GLY I 178 55.004 62.200 138.862 1.00 35.19 C +ATOM 14456 C GLY I 178 55.909 62.242 137.640 1.00 35.73 C +ATOM 14457 O GLY I 178 55.544 61.760 136.569 1.00 35.87 O +ATOM 14458 N PRO I 179 57.065 62.889 137.739 1.00 32.21 N +ATOM 14459 CA PRO I 179 57.997 62.962 136.618 1.00 32.67 C +ATOM 14460 C PRO I 179 59.031 61.835 136.707 1.00 34.54 C +ATOM 14461 O PRO I 179 59.538 61.521 137.793 1.00 38.77 O +ATOM 14462 CB PRO I 179 58.639 64.319 136.814 1.00 33.48 C +ATOM 14463 CG PRO I 179 58.675 64.457 138.234 1.00 22.68 C +ATOM 14464 CD PRO I 179 57.425 63.855 138.782 1.00 32.37 C +ATOM 14465 N PHE I 180 59.343 61.225 135.568 1.00 32.83 N +ATOM 14466 CA PHE I 180 60.301 60.116 135.499 1.00 28.98 C +ATOM 14467 C PHE I 180 60.846 60.010 134.075 1.00 27.93 C +ATOM 14468 O PHE I 180 60.301 60.604 133.144 1.00 27.12 O +ATOM 14469 CB PHE I 180 59.607 58.808 135.884 1.00 20.92 C +ATOM 14470 CG PHE I 180 58.342 58.568 135.135 1.00 22.79 C +ATOM 14471 CD1 PHE I 180 57.132 59.064 135.618 1.00 31.62 C +ATOM 14472 CD2 PHE I 180 58.353 57.883 133.929 1.00 22.34 C +ATOM 14473 CE1 PHE I 180 55.943 58.881 134.905 1.00 34.64 C +ATOM 14474 CE2 PHE I 180 57.175 57.694 133.206 1.00 32.74 C +ATOM 14475 CZ PHE I 180 55.965 58.194 133.695 1.00 36.96 C +ATOM 14476 N SER I 181 61.913 59.241 133.912 1.00 28.77 N +ATOM 14477 CA SER I 181 62.528 59.053 132.603 1.00 30.99 C +ATOM 14478 C SER I 181 62.833 57.587 132.277 1.00 30.59 C +ATOM 14479 O SER I 181 63.786 56.998 132.820 1.00 38.56 O +ATOM 14480 CB SER I 181 63.813 59.880 132.492 1.00 34.48 C +ATOM 14481 OG SER I 181 63.661 60.918 131.535 1.00 56.71 O +ATOM 14482 N PRO I 182 61.995 56.960 131.429 1.00 22.37 N +ATOM 14483 CA PRO I 182 62.168 55.563 131.021 1.00 20.75 C +ATOM 14484 C PRO I 182 63.442 55.508 130.181 1.00 24.05 C +ATOM 14485 O PRO I 182 63.895 56.548 129.692 1.00 29.97 O +ATOM 14486 CB PRO I 182 60.951 55.316 130.146 1.00 11.73 C +ATOM 14487 CG PRO I 182 59.965 56.300 130.622 1.00 14.84 C +ATOM 14488 CD PRO I 182 60.788 57.527 130.819 1.00 18.17 C +ATOM 14489 N ASN I 183 64.018 54.324 129.997 1.00 20.16 N +ATOM 14490 CA ASN I 183 65.234 54.230 129.202 1.00 14.93 C +ATOM 14491 C ASN I 183 65.244 53.107 128.180 1.00 15.47 C +ATOM 14492 O ASN I 183 66.304 52.635 127.781 1.00 25.27 O +ATOM 14493 CB ASN I 183 66.485 54.177 130.085 1.00 10.11 C +ATOM 14494 CG ASN I 183 66.609 52.892 130.859 1.00 8.50 C +ATOM 14495 OD1 ASN I 183 65.677 52.100 130.944 1.00 8.50 O +ATOM 14496 ND2 ASN I 183 67.766 52.696 131.468 1.00 13.67 N +ATOM 14497 N VAL I 184 64.059 52.667 127.782 1.00 11.21 N +ATOM 14498 CA VAL I 184 63.900 51.625 126.777 1.00 9.67 C +ATOM 14499 C VAL I 184 62.720 52.069 125.922 1.00 11.62 C +ATOM 14500 O VAL I 184 62.896 52.391 124.755 1.00 19.87 O +ATOM 14501 CB VAL I 184 63.604 50.230 127.385 1.00 8.50 C +ATOM 14502 CG1 VAL I 184 63.374 49.216 126.283 1.00 11.49 C +ATOM 14503 CG2 VAL I 184 64.734 49.775 128.254 1.00 8.50 C +ATOM 14504 N LEU I 185 61.531 52.121 126.513 1.00 8.50 N +ATOM 14505 CA LEU I 185 60.341 52.562 125.810 1.00 8.50 C +ATOM 14506 C LEU I 185 59.899 53.808 126.535 1.00 13.72 C +ATOM 14507 O LEU I 185 59.809 53.791 127.755 1.00 17.34 O +ATOM 14508 CB LEU I 185 59.248 51.510 125.873 1.00 8.53 C +ATOM 14509 CG LEU I 185 58.882 50.834 124.553 1.00 8.50 C +ATOM 14510 CD1 LEU I 185 60.134 50.356 123.895 1.00 12.18 C +ATOM 14511 CD2 LEU I 185 57.937 49.671 124.775 1.00 11.39 C +ATOM 14512 N ASN I 186 59.666 54.893 125.798 1.00 18.13 N +ATOM 14513 CA ASN I 186 59.260 56.167 126.390 1.00 13.24 C +ATOM 14514 C ASN I 186 58.016 56.687 125.686 1.00 14.33 C +ATOM 14515 O ASN I 186 58.071 57.015 124.510 1.00 21.59 O +ATOM 14516 CB ASN I 186 60.413 57.169 126.266 1.00 8.50 C +ATOM 14517 CG ASN I 186 60.150 58.456 126.997 1.00 8.50 C +ATOM 14518 OD1 ASN I 186 59.010 58.843 127.192 1.00 8.80 O +ATOM 14519 ND2 ASN I 186 61.212 59.131 127.405 1.00 15.30 N +ATOM 14520 N TRP I 187 56.900 56.769 126.406 1.00 12.63 N +ATOM 14521 CA TRP I 187 55.638 57.239 125.832 1.00 8.50 C +ATOM 14522 C TRP I 187 55.713 58.688 125.362 1.00 11.65 C +ATOM 14523 O TRP I 187 54.896 59.115 124.558 1.00 17.24 O +ATOM 14524 CB TRP I 187 54.502 57.065 126.835 1.00 8.50 C +ATOM 14525 CG TRP I 187 53.132 57.135 126.260 1.00 8.50 C +ATOM 14526 CD1 TRP I 187 52.208 58.076 126.507 1.00 8.50 C +ATOM 14527 CD2 TRP I 187 52.518 56.196 125.389 1.00 8.50 C +ATOM 14528 NE1 TRP I 187 51.046 57.792 125.849 1.00 8.50 N +ATOM 14529 CE2 TRP I 187 51.209 56.634 125.157 1.00 8.50 C +ATOM 14530 CE3 TRP I 187 52.944 55.018 124.787 1.00 8.50 C +ATOM 14531 CZ2 TRP I 187 50.321 55.950 124.342 1.00 8.50 C +ATOM 14532 CZ3 TRP I 187 52.057 54.336 123.973 1.00 8.80 C +ATOM 14533 CH2 TRP I 187 50.759 54.803 123.763 1.00 8.50 C +ATOM 14534 N ARG I 188 56.697 59.441 125.847 1.00 11.23 N +ATOM 14535 CA ARG I 188 56.858 60.839 125.460 1.00 18.09 C +ATOM 14536 C ARG I 188 57.679 60.995 124.191 1.00 24.47 C +ATOM 14537 O ARG I 188 57.655 62.045 123.552 1.00 30.38 O +ATOM 14538 CB ARG I 188 57.490 61.633 126.588 1.00 20.33 C +ATOM 14539 CG ARG I 188 56.610 61.717 127.810 1.00 20.47 C +ATOM 14540 CD ARG I 188 55.656 62.861 127.682 1.00 15.94 C +ATOM 14541 NE ARG I 188 55.980 63.905 128.647 1.00 24.63 N +ATOM 14542 CZ ARG I 188 55.647 65.184 128.532 1.00 20.02 C +ATOM 14543 NH1 ARG I 188 54.966 65.645 127.485 1.00 19.10 N +ATOM 14544 NH2 ARG I 188 56.002 66.005 129.490 1.00 11.29 N +ATOM 14545 N ALA I 189 58.403 59.941 123.832 1.00 25.10 N +ATOM 14546 CA ALA I 189 59.240 59.916 122.636 1.00 19.94 C +ATOM 14547 C ALA I 189 59.073 58.530 122.045 1.00 18.52 C +ATOM 14548 O ALA I 189 60.044 57.802 121.876 1.00 23.43 O +ATOM 14549 CB ALA I 189 60.707 60.160 123.011 1.00 11.67 C +ATOM 14550 N LEU I 190 57.826 58.163 121.770 1.00 16.64 N +ATOM 14551 CA LEU I 190 57.502 56.847 121.232 1.00 20.42 C +ATOM 14552 C LEU I 190 57.759 56.790 119.729 1.00 25.97 C +ATOM 14553 O LEU I 190 57.525 57.769 119.006 1.00 30.15 O +ATOM 14554 CB LEU I 190 56.043 56.484 121.527 1.00 8.52 C +ATOM 14555 CG LEU I 190 55.687 55.005 121.429 1.00 8.50 C +ATOM 14556 CD1 LEU I 190 56.149 54.306 122.685 1.00 8.50 C +ATOM 14557 CD2 LEU I 190 54.197 54.827 121.261 1.00 13.61 C +ATOM 14558 N LYS I 191 58.316 55.671 119.274 1.00 30.34 N +ATOM 14559 CA LYS I 191 58.607 55.454 117.862 1.00 28.35 C +ATOM 14560 C LYS I 191 57.820 54.200 117.525 1.00 24.21 C +ATOM 14561 O LYS I 191 58.209 53.100 117.886 1.00 25.06 O +ATOM 14562 CB LYS I 191 60.108 55.245 117.665 1.00 36.59 C +ATOM 14563 CG LYS I 191 60.611 55.648 116.282 1.00 60.17 C +ATOM 14564 CD LYS I 191 62.118 55.899 116.293 1.00 78.12 C +ATOM 14565 CE LYS I 191 62.627 56.365 114.932 1.00 90.76 C +ATOM 14566 NZ LYS I 191 64.070 56.775 114.965 1.00 95.08 N +ATOM 14567 N TYR I 192 56.686 54.372 116.867 1.00 22.19 N +ATOM 14568 CA TYR I 192 55.827 53.241 116.573 1.00 26.03 C +ATOM 14569 C TYR I 192 55.383 53.185 115.126 1.00 31.56 C +ATOM 14570 O TYR I 192 55.676 54.089 114.340 1.00 39.81 O +ATOM 14571 CB TYR I 192 54.585 53.314 117.475 1.00 24.71 C +ATOM 14572 CG TYR I 192 53.749 54.557 117.245 1.00 15.62 C +ATOM 14573 CD1 TYR I 192 54.181 55.806 117.686 1.00 13.92 C +ATOM 14574 CD2 TYR I 192 52.556 54.491 116.544 1.00 8.50 C +ATOM 14575 CE1 TYR I 192 53.440 56.955 117.424 1.00 12.90 C +ATOM 14576 CE2 TYR I 192 51.812 55.628 116.279 1.00 8.50 C +ATOM 14577 CZ TYR I 192 52.254 56.860 116.716 1.00 13.79 C +ATOM 14578 OH TYR I 192 51.513 57.999 116.432 1.00 17.81 O +ATOM 14579 N GLU I 193 54.606 52.154 114.810 1.00 32.09 N +ATOM 14580 CA GLU I 193 54.074 51.942 113.476 1.00 34.59 C +ATOM 14581 C GLU I 193 52.719 51.271 113.664 1.00 35.09 C +ATOM 14582 O GLU I 193 52.611 50.231 114.314 1.00 37.82 O +ATOM 14583 CB GLU I 193 55.018 51.041 112.692 1.00 51.76 C +ATOM 14584 CG GLU I 193 54.818 51.028 111.186 1.00 69.01 C +ATOM 14585 CD GLU I 193 55.833 50.138 110.488 1.00 80.54 C +ATOM 14586 OE1 GLU I 193 55.578 48.912 110.391 1.00 85.54 O +ATOM 14587 OE2 GLU I 193 56.889 50.663 110.057 1.00 85.63 O +ATOM 14588 N VAL I 194 51.678 51.911 113.154 1.00 32.79 N +ATOM 14589 CA VAL I 194 50.319 51.412 113.268 1.00 32.12 C +ATOM 14590 C VAL I 194 49.977 50.514 112.079 1.00 34.16 C +ATOM 14591 O VAL I 194 50.485 50.715 110.979 1.00 38.76 O +ATOM 14592 CB VAL I 194 49.323 52.594 113.344 1.00 26.13 C +ATOM 14593 CG1 VAL I 194 47.887 52.103 113.307 1.00 37.84 C +ATOM 14594 CG2 VAL I 194 49.555 53.375 114.600 1.00 31.47 C +ATOM 14595 N GLN I 195 49.116 49.528 112.303 1.00 34.51 N +ATOM 14596 CA GLN I 195 48.717 48.619 111.249 1.00 31.91 C +ATOM 14597 C GLN I 195 47.293 48.174 111.490 1.00 27.18 C +ATOM 14598 O GLN I 195 46.979 47.608 112.538 1.00 30.96 O +ATOM 14599 CB GLN I 195 49.625 47.390 111.246 1.00 47.40 C +ATOM 14600 CG GLN I 195 49.814 46.756 109.887 1.00 62.92 C +ATOM 14601 CD GLN I 195 50.573 47.668 108.953 1.00 74.28 C +ATOM 14602 OE1 GLN I 195 50.041 48.106 107.938 1.00 86.28 O +ATOM 14603 NE2 GLN I 195 51.824 47.970 109.297 1.00 74.98 N +ATOM 14604 N GLY I 196 46.422 48.453 110.534 1.00 21.81 N +ATOM 14605 CA GLY I 196 45.042 48.030 110.668 1.00 25.96 C +ATOM 14606 C GLY I 196 44.088 49.060 111.231 1.00 30.03 C +ATOM 14607 O GLY I 196 44.307 50.266 111.111 1.00 35.57 O +ATOM 14608 N GLU I 197 43.031 48.569 111.869 1.00 30.49 N +ATOM 14609 CA GLU I 197 41.987 49.409 112.451 1.00 21.27 C +ATOM 14610 C GLU I 197 42.325 49.920 113.844 1.00 19.19 C +ATOM 14611 O GLU I 197 41.723 49.486 114.829 1.00 26.83 O +ATOM 14612 CB GLU I 197 40.685 48.609 112.510 1.00 21.51 C +ATOM 14613 CG GLU I 197 39.449 49.449 112.741 1.00 37.38 C +ATOM 14614 CD GLU I 197 38.802 49.976 111.453 1.00 37.58 C +ATOM 14615 OE1 GLU I 197 39.504 50.109 110.419 1.00 31.11 O +ATOM 14616 OE2 GLU I 197 37.577 50.253 111.494 1.00 31.99 O +ATOM 14617 N VAL I 198 43.313 50.800 113.936 1.00 14.77 N +ATOM 14618 CA VAL I 198 43.702 51.380 115.224 1.00 15.04 C +ATOM 14619 C VAL I 198 43.840 52.896 115.074 1.00 16.73 C +ATOM 14620 O VAL I 198 44.430 53.388 114.109 1.00 22.36 O +ATOM 14621 CB VAL I 198 44.987 50.722 115.833 1.00 10.21 C +ATOM 14622 CG1 VAL I 198 45.684 49.884 114.812 1.00 9.36 C +ATOM 14623 CG2 VAL I 198 45.923 51.761 116.405 1.00 8.50 C +ATOM 14624 N PHE I 199 43.231 53.625 116.002 1.00 14.12 N +ATOM 14625 CA PHE I 199 43.232 55.083 115.984 1.00 14.79 C +ATOM 14626 C PHE I 199 43.897 55.656 117.221 1.00 14.93 C +ATOM 14627 O PHE I 199 44.033 54.973 118.233 1.00 19.71 O +ATOM 14628 CB PHE I 199 41.788 55.609 115.939 1.00 12.33 C +ATOM 14629 CG PHE I 199 40.927 54.949 114.894 1.00 20.40 C +ATOM 14630 CD1 PHE I 199 40.248 53.776 115.182 1.00 17.52 C +ATOM 14631 CD2 PHE I 199 40.804 55.494 113.621 1.00 27.65 C +ATOM 14632 CE1 PHE I 199 39.465 53.154 114.226 1.00 19.64 C +ATOM 14633 CE2 PHE I 199 40.018 54.873 112.656 1.00 24.53 C +ATOM 14634 CZ PHE I 199 39.349 53.703 112.960 1.00 20.27 C +ATOM 14635 N THR I 200 44.268 56.928 117.143 1.00 14.18 N +ATOM 14636 CA THR I 200 44.888 57.629 118.256 1.00 11.35 C +ATOM 14637 C THR I 200 43.880 58.665 118.748 1.00 11.68 C +ATOM 14638 O THR I 200 43.527 59.571 118.010 1.00 23.54 O +ATOM 14639 CB THR I 200 46.167 58.340 117.811 1.00 9.75 C +ATOM 14640 OG1 THR I 200 47.072 57.391 117.233 1.00 19.82 O +ATOM 14641 CG2 THR I 200 46.836 59.003 118.988 1.00 15.44 C +ATOM 14642 N LYS I 201 43.368 58.489 119.962 1.00 13.14 N +ATOM 14643 CA LYS I 201 42.387 59.404 120.551 1.00 8.50 C +ATOM 14644 C LYS I 201 42.833 59.823 121.963 1.00 9.42 C +ATOM 14645 O LYS I 201 43.793 59.277 122.506 1.00 12.33 O +ATOM 14646 CB LYS I 201 41.002 58.754 120.601 1.00 8.50 C +ATOM 14647 CG LYS I 201 40.346 58.494 119.261 1.00 8.50 C +ATOM 14648 CD LYS I 201 40.305 59.725 118.401 1.00 10.43 C +ATOM 14649 CE LYS I 201 39.188 59.669 117.370 1.00 18.39 C +ATOM 14650 NZ LYS I 201 37.849 59.751 118.040 1.00 22.41 N +ATOM 14651 N PRO I 202 42.188 60.842 122.547 1.00 8.50 N +ATOM 14652 CA PRO I 202 42.526 61.323 123.883 1.00 8.50 C +ATOM 14653 C PRO I 202 42.234 60.239 124.909 1.00 12.01 C +ATOM 14654 O PRO I 202 41.192 59.628 124.856 1.00 14.58 O +ATOM 14655 CB PRO I 202 41.551 62.475 124.070 1.00 8.50 C +ATOM 14656 CG PRO I 202 41.281 62.928 122.718 1.00 11.45 C +ATOM 14657 CD PRO I 202 41.116 61.665 121.975 1.00 13.21 C +ATOM 14658 N GLN I 203 43.118 60.046 125.879 1.00 8.50 N +ATOM 14659 CA GLN I 203 42.912 59.020 126.883 1.00 8.50 C +ATOM 14660 C GLN I 203 41.717 59.264 127.793 1.00 8.50 C +ATOM 14661 O GLN I 203 41.461 60.395 128.192 1.00 8.50 O +ATOM 14662 CB GLN I 203 44.164 58.858 127.720 1.00 8.62 C +ATOM 14663 CG GLN I 203 44.574 60.082 128.474 1.00 8.50 C +ATOM 14664 CD GLN I 203 45.782 59.833 129.338 1.00 10.36 C +ATOM 14665 OE1 GLN I 203 45.807 60.206 130.496 1.00 27.85 O +ATOM 14666 NE2 GLN I 203 46.795 59.192 128.776 1.00 25.78 N +ATOM 14667 N LEU I 204 41.026 58.179 128.152 1.00 11.80 N +ATOM 14668 CA LEU I 204 39.847 58.241 129.014 1.00 8.50 C +ATOM 14669 C LEU I 204 40.182 58.237 130.479 1.00 8.50 C +ATOM 14670 O LEU I 204 39.390 58.703 131.292 1.00 10.41 O +ATOM 14671 CB LEU I 204 38.892 57.095 128.723 1.00 8.50 C +ATOM 14672 CG LEU I 204 38.546 56.981 127.256 1.00 8.50 C +ATOM 14673 CD1 LEU I 204 39.473 55.962 126.649 1.00 21.19 C +ATOM 14674 CD2 LEU I 204 37.106 56.576 127.094 1.00 8.50 C +ATOM 14675 N TRP I 205 41.295 57.604 130.826 1.00 11.93 N +ATOM 14676 CA TRP I 205 41.738 57.576 132.213 1.00 20.34 C +ATOM 14677 C TRP I 205 42.418 58.916 132.458 1.00 26.26 C +ATOM 14678 O TRP I 205 42.934 59.526 131.525 1.00 34.08 O +ATOM 14679 CB TRP I 205 42.711 56.423 132.482 1.00 18.80 C +ATOM 14680 CG TRP I 205 43.753 56.233 131.445 1.00 8.50 C +ATOM 14681 CD1 TRP I 205 44.956 56.853 131.361 1.00 8.50 C +ATOM 14682 CD2 TRP I 205 43.676 55.344 130.340 1.00 10.92 C +ATOM 14683 NE1 TRP I 205 45.640 56.406 130.267 1.00 8.50 N +ATOM 14684 CE2 TRP I 205 44.876 55.477 129.617 1.00 8.50 C +ATOM 14685 CE3 TRP I 205 42.701 54.445 129.884 1.00 10.17 C +ATOM 14686 CZ2 TRP I 205 45.132 54.747 128.458 1.00 11.05 C +ATOM 14687 CZ3 TRP I 205 42.954 53.723 128.736 1.00 12.07 C +ATOM 14688 CH2 TRP I 205 44.162 53.878 128.035 1.00 13.68 C +ATOM 14689 N PRO I 206 42.350 59.422 133.696 1.00 28.25 N +ATOM 14690 CA PRO I 206 42.960 60.698 134.052 1.00 29.76 C +ATOM 14691 C PRO I 206 44.476 60.605 134.258 1.00 35.37 C +ATOM 14692 O PRO I 206 45.159 61.615 133.986 1.00 39.46 O +ATOM 14693 CB PRO I 206 42.225 61.057 135.340 1.00 27.01 C +ATOM 14694 CG PRO I 206 42.043 59.739 135.988 1.00 27.94 C +ATOM 14695 CD PRO I 206 41.582 58.877 134.832 1.00 35.72 C +ATOM 14696 OXT PRO I 206 44.965 59.534 134.686 1.00 37.70 O +TER 14697 PRO I 206 +ATOM 14698 N GLN J 1 12.736 79.474 122.373 1.00 63.74 N +ATOM 14699 CA GLN J 1 13.706 80.460 122.916 1.00 53.67 C +ATOM 14700 C GLN J 1 13.400 80.589 124.396 1.00 50.65 C +ATOM 14701 O GLN J 1 13.082 81.673 124.856 1.00 59.74 O +ATOM 14702 CB GLN J 1 13.448 81.813 122.256 1.00 56.75 C +ATOM 14703 CG GLN J 1 12.896 81.711 120.844 1.00 76.50 C +ATOM 14704 CD GLN J 1 13.905 81.130 119.858 1.00 88.50 C +ATOM 14705 OE1 GLN J 1 14.803 80.367 120.239 1.00 89.56 O +ATOM 14706 NE2 GLN J 1 13.757 81.483 118.584 1.00 93.92 N +ATOM 14707 N THR J 2 13.453 79.490 125.135 1.00 40.42 N +ATOM 14708 CA THR J 2 13.141 79.540 126.550 1.00 30.47 C +ATOM 14709 C THR J 2 14.339 79.075 127.337 1.00 27.49 C +ATOM 14710 O THR J 2 15.050 78.181 126.905 1.00 35.25 O +ATOM 14711 CB THR J 2 11.959 78.642 126.864 1.00 18.95 C +ATOM 14712 OG1 THR J 2 10.916 78.902 125.919 1.00 36.67 O +ATOM 14713 CG2 THR J 2 11.450 78.883 128.248 1.00 25.39 C +ATOM 14714 N ASP J 3 14.612 79.736 128.449 1.00 22.76 N +ATOM 14715 CA ASP J 3 15.728 79.350 129.279 1.00 19.54 C +ATOM 14716 C ASP J 3 15.196 78.270 130.185 1.00 26.36 C +ATOM 14717 O ASP J 3 14.539 78.551 131.196 1.00 28.17 O +ATOM 14718 CB ASP J 3 16.242 80.522 130.115 1.00 22.63 C +ATOM 14719 CG ASP J 3 17.647 80.278 130.662 1.00 22.99 C +ATOM 14720 OD1 ASP J 3 18.106 79.116 130.650 1.00 16.41 O +ATOM 14721 OD2 ASP J 3 18.299 81.250 131.094 1.00 30.57 O +ATOM 14722 N MET J 4 15.458 77.025 129.804 1.00 26.31 N +ATOM 14723 CA MET J 4 14.991 75.878 130.570 1.00 17.24 C +ATOM 14724 C MET J 4 15.865 75.553 131.772 1.00 15.83 C +ATOM 14725 O MET J 4 15.715 74.491 132.368 1.00 20.28 O +ATOM 14726 CB MET J 4 14.860 74.657 129.669 1.00 8.50 C +ATOM 14727 CG MET J 4 13.711 74.721 128.712 1.00 8.50 C +ATOM 14728 SD MET J 4 12.188 74.863 129.611 1.00 8.50 S +ATOM 14729 CE MET J 4 11.911 73.314 130.102 1.00 8.50 C +ATOM 14730 N SER J 5 16.743 76.481 132.152 1.00 10.27 N +ATOM 14731 CA SER J 5 17.641 76.278 133.282 1.00 11.74 C +ATOM 14732 C SER J 5 16.922 75.933 134.567 1.00 13.64 C +ATOM 14733 O SER J 5 15.925 76.556 134.917 1.00 23.14 O +ATOM 14734 CB SER J 5 18.502 77.515 133.524 1.00 19.59 C +ATOM 14735 OG SER J 5 19.512 77.652 132.551 1.00 22.29 O +ATOM 14736 N ARG J 6 17.461 74.948 135.269 1.00 12.11 N +ATOM 14737 CA ARG J 6 16.904 74.509 136.536 1.00 15.54 C +ATOM 14738 C ARG J 6 15.509 73.853 136.423 1.00 16.63 C +ATOM 14739 O ARG J 6 14.832 73.594 137.426 1.00 15.20 O +ATOM 14740 CB ARG J 6 16.936 75.690 137.511 1.00 9.75 C +ATOM 14741 CG ARG J 6 18.328 75.964 138.023 1.00 8.50 C +ATOM 14742 CD ARG J 6 18.603 74.949 139.094 1.00 8.50 C +ATOM 14743 NE ARG J 6 19.992 74.865 139.539 1.00 43.40 N +ATOM 14744 CZ ARG J 6 20.354 74.558 140.786 1.00 49.05 C +ATOM 14745 NH1 ARG J 6 19.424 74.315 141.711 1.00 47.23 N +ATOM 14746 NH2 ARG J 6 21.644 74.467 141.107 1.00 52.08 N +ATOM 14747 N LYS J 7 15.122 73.528 135.194 1.00 16.13 N +ATOM 14748 CA LYS J 7 13.842 72.888 134.936 1.00 12.28 C +ATOM 14749 C LYS J 7 13.983 71.513 134.251 1.00 10.75 C +ATOM 14750 O LYS J 7 15.053 71.159 133.729 1.00 8.50 O +ATOM 14751 CB LYS J 7 12.958 73.832 134.128 1.00 8.50 C +ATOM 14752 CG LYS J 7 12.489 75.008 134.932 1.00 8.50 C +ATOM 14753 CD LYS J 7 12.019 76.121 134.015 1.00 41.24 C +ATOM 14754 CE LYS J 7 11.631 77.373 134.796 1.00 48.34 C +ATOM 14755 NZ LYS J 7 11.398 78.519 133.875 1.00 58.12 N +ATOM 14756 N ALA J 8 12.913 70.733 134.315 1.00 8.50 N +ATOM 14757 CA ALA J 8 12.885 69.416 133.743 1.00 8.50 C +ATOM 14758 C ALA J 8 11.491 69.145 133.255 1.00 8.50 C +ATOM 14759 O ALA J 8 10.552 69.699 133.789 1.00 10.13 O +ATOM 14760 CB ALA J 8 13.254 68.391 134.800 1.00 8.50 C +ATOM 14761 N PHE J 9 11.359 68.347 132.199 1.00 11.22 N +ATOM 14762 CA PHE J 9 10.053 67.976 131.674 1.00 8.50 C +ATOM 14763 C PHE J 9 9.719 66.736 132.463 1.00 8.50 C +ATOM 14764 O PHE J 9 10.582 65.889 132.662 1.00 8.50 O +ATOM 14765 CB PHE J 9 10.137 67.607 130.191 1.00 10.87 C +ATOM 14766 CG PHE J 9 10.426 68.769 129.280 1.00 8.50 C +ATOM 14767 CD1 PHE J 9 9.519 69.810 129.155 1.00 8.50 C +ATOM 14768 CD2 PHE J 9 11.570 68.783 128.490 1.00 8.50 C +ATOM 14769 CE1 PHE J 9 9.738 70.824 128.263 1.00 8.50 C +ATOM 14770 CE2 PHE J 9 11.791 69.803 127.594 1.00 8.50 C +ATOM 14771 CZ PHE J 9 10.876 70.819 127.478 1.00 8.50 C +ATOM 14772 N VAL J 10 8.490 66.629 132.931 1.00 8.50 N +ATOM 14773 CA VAL J 10 8.100 65.463 133.698 1.00 8.70 C +ATOM 14774 C VAL J 10 6.840 64.772 133.155 1.00 12.69 C +ATOM 14775 O VAL J 10 5.780 65.398 133.036 1.00 12.24 O +ATOM 14776 CB VAL J 10 8.001 65.784 135.223 1.00 8.50 C +ATOM 14777 CG1 VAL J 10 7.619 67.215 135.445 1.00 8.50 C +ATOM 14778 CG2 VAL J 10 6.988 64.872 135.911 1.00 8.50 C +ATOM 14779 N PHE J 11 7.006 63.499 132.770 1.00 10.05 N +ATOM 14780 CA PHE J 11 5.945 62.646 132.240 1.00 9.69 C +ATOM 14781 C PHE J 11 5.492 61.753 133.405 1.00 11.61 C +ATOM 14782 O PHE J 11 6.074 60.699 133.649 1.00 8.50 O +ATOM 14783 CB PHE J 11 6.505 61.778 131.124 1.00 8.50 C +ATOM 14784 CG PHE J 11 7.219 62.542 130.046 1.00 8.50 C +ATOM 14785 CD1 PHE J 11 6.536 63.024 128.935 1.00 14.31 C +ATOM 14786 CD2 PHE J 11 8.573 62.758 130.129 1.00 8.50 C +ATOM 14787 CE1 PHE J 11 7.192 63.710 127.929 1.00 9.35 C +ATOM 14788 CE2 PHE J 11 9.237 63.444 129.120 1.00 13.65 C +ATOM 14789 CZ PHE J 11 8.540 63.919 128.023 1.00 10.07 C +ATOM 14790 N PRO J 12 4.444 62.174 134.140 1.00 14.71 N +ATOM 14791 CA PRO J 12 3.888 61.458 135.296 1.00 14.40 C +ATOM 14792 C PRO J 12 3.277 60.083 135.072 1.00 21.13 C +ATOM 14793 O PRO J 12 3.271 59.266 135.991 1.00 32.18 O +ATOM 14794 CB PRO J 12 2.833 62.435 135.841 1.00 15.33 C +ATOM 14795 CG PRO J 12 3.257 63.769 135.300 1.00 11.36 C +ATOM 14796 CD PRO J 12 3.688 63.418 133.908 1.00 14.89 C +ATOM 14797 N LYS J 13 2.689 59.834 133.909 1.00 26.81 N +ATOM 14798 CA LYS J 13 2.102 58.521 133.668 1.00 33.72 C +ATOM 14799 C LYS J 13 2.325 57.946 132.284 1.00 37.14 C +ATOM 14800 O LYS J 13 2.624 58.680 131.327 1.00 36.01 O +ATOM 14801 CB LYS J 13 0.612 58.482 134.040 1.00 42.48 C +ATOM 14802 CG LYS J 13 -0.250 59.652 133.556 1.00 46.05 C +ATOM 14803 CD LYS J 13 -1.644 59.549 134.184 1.00 53.55 C +ATOM 14804 CE LYS J 13 -2.502 60.775 133.928 1.00 60.09 C +ATOM 14805 NZ LYS J 13 -2.840 60.957 132.487 1.00 71.92 N +ATOM 14806 N GLU J 14 2.205 56.621 132.209 1.00 38.66 N +ATOM 14807 CA GLU J 14 2.390 55.873 130.969 1.00 45.63 C +ATOM 14808 C GLU J 14 1.405 56.336 129.922 1.00 42.04 C +ATOM 14809 O GLU J 14 0.202 56.288 130.136 1.00 42.56 O +ATOM 14810 CB GLU J 14 2.227 54.378 131.216 1.00 59.40 C +ATOM 14811 CG GLU J 14 1.129 54.034 132.192 1.00 72.59 C +ATOM 14812 CD GLU J 14 1.598 53.021 133.213 1.00 87.00 C +ATOM 14813 OE1 GLU J 14 2.315 53.433 134.158 1.00 86.12 O +ATOM 14814 OE2 GLU J 14 1.266 51.818 133.056 1.00 92.35 O +ATOM 14815 N SER J 15 1.930 56.812 128.802 1.00 43.69 N +ATOM 14816 CA SER J 15 1.092 57.311 127.741 1.00 42.95 C +ATOM 14817 C SER J 15 1.478 56.817 126.364 1.00 42.56 C +ATOM 14818 O SER J 15 2.492 56.144 126.165 1.00 36.61 O +ATOM 14819 CB SER J 15 1.035 58.849 127.780 1.00 53.96 C +ATOM 14820 OG SER J 15 2.329 59.447 127.789 1.00 64.99 O +ATOM 14821 N ASP J 16 0.608 57.151 125.431 1.00 44.44 N +ATOM 14822 CA ASP J 16 0.722 56.790 124.047 1.00 44.08 C +ATOM 14823 C ASP J 16 0.788 58.134 123.318 1.00 43.39 C +ATOM 14824 O ASP J 16 1.268 58.224 122.196 1.00 44.59 O +ATOM 14825 CB ASP J 16 -0.583 56.067 123.701 1.00 54.30 C +ATOM 14826 CG ASP J 16 -0.459 55.142 122.521 1.00 71.34 C +ATOM 14827 OD1 ASP J 16 0.669 54.680 122.250 1.00 81.76 O +ATOM 14828 OD2 ASP J 16 -1.506 54.858 121.884 1.00 73.72 O +ATOM 14829 N THR J 17 0.385 59.186 124.028 1.00 41.28 N +ATOM 14830 CA THR J 17 0.281 60.538 123.497 1.00 40.37 C +ATOM 14831 C THR J 17 1.246 61.624 123.973 1.00 40.42 C +ATOM 14832 O THR J 17 1.386 62.656 123.312 1.00 45.53 O +ATOM 14833 CB THR J 17 -1.154 61.052 123.764 1.00 39.24 C +ATOM 14834 OG1 THR J 17 -1.493 60.831 125.140 1.00 29.19 O +ATOM 14835 CG2 THR J 17 -2.154 60.309 122.893 1.00 48.63 C +ATOM 14836 N SER J 18 1.867 61.428 125.129 1.00 34.16 N +ATOM 14837 CA SER J 18 2.766 62.436 125.675 1.00 26.04 C +ATOM 14838 C SER J 18 4.185 62.421 125.105 1.00 20.82 C +ATOM 14839 O SER J 18 4.809 61.368 124.992 1.00 9.80 O +ATOM 14840 CB SER J 18 2.814 62.318 127.202 1.00 29.82 C +ATOM 14841 OG SER J 18 1.507 62.397 127.769 1.00 36.89 O +ATOM 14842 N TYR J 19 4.677 63.612 124.754 1.00 20.99 N +ATOM 14843 CA TYR J 19 6.024 63.796 124.214 1.00 15.25 C +ATOM 14844 C TYR J 19 6.343 65.288 124.049 1.00 10.84 C +ATOM 14845 O TYR J 19 5.446 66.132 124.110 1.00 15.25 O +ATOM 14846 CB TYR J 19 6.180 63.051 122.879 1.00 14.97 C +ATOM 14847 CG TYR J 19 5.410 63.639 121.705 1.00 17.53 C +ATOM 14848 CD1 TYR J 19 5.959 64.648 120.927 1.00 26.40 C +ATOM 14849 CD2 TYR J 19 4.150 63.177 121.370 1.00 12.58 C +ATOM 14850 CE1 TYR J 19 5.271 65.183 119.846 1.00 32.88 C +ATOM 14851 CE2 TYR J 19 3.456 63.703 120.292 1.00 28.97 C +ATOM 14852 CZ TYR J 19 4.020 64.708 119.534 1.00 32.87 C +ATOM 14853 OH TYR J 19 3.332 65.255 118.466 1.00 49.34 O +ATOM 14854 N VAL J 20 7.620 65.598 123.863 1.00 8.50 N +ATOM 14855 CA VAL J 20 8.088 66.959 123.675 1.00 8.87 C +ATOM 14856 C VAL J 20 8.938 66.969 122.423 1.00 14.33 C +ATOM 14857 O VAL J 20 9.869 66.192 122.307 1.00 14.88 O +ATOM 14858 CB VAL J 20 8.957 67.437 124.838 1.00 8.50 C +ATOM 14859 CG1 VAL J 20 9.468 68.806 124.567 1.00 8.50 C +ATOM 14860 CG2 VAL J 20 8.144 67.471 126.093 1.00 19.45 C +ATOM 14861 N SER J 21 8.594 67.831 121.477 1.00 17.58 N +ATOM 14862 CA SER J 21 9.320 67.949 120.235 1.00 12.99 C +ATOM 14863 C SER J 21 10.328 69.069 120.344 1.00 12.76 C +ATOM 14864 O SER J 21 9.991 70.167 120.769 1.00 17.54 O +ATOM 14865 CB SER J 21 8.356 68.263 119.113 1.00 15.24 C +ATOM 14866 OG SER J 21 9.049 68.339 117.880 1.00 43.00 O +ATOM 14867 N LEU J 22 11.564 68.780 119.976 1.00 8.50 N +ATOM 14868 CA LEU J 22 12.639 69.742 120.019 1.00 8.50 C +ATOM 14869 C LEU J 22 12.945 70.177 118.593 1.00 19.75 C +ATOM 14870 O LEU J 22 13.087 69.343 117.689 1.00 22.84 O +ATOM 14871 CB LEU J 22 13.873 69.132 120.681 1.00 8.50 C +ATOM 14872 CG LEU J 22 14.126 69.382 122.170 1.00 8.50 C +ATOM 14873 CD1 LEU J 22 12.874 69.360 122.994 1.00 8.50 C +ATOM 14874 CD2 LEU J 22 15.111 68.359 122.671 1.00 12.30 C +ATOM 14875 N LYS J 23 13.026 71.494 118.398 1.00 27.47 N +ATOM 14876 CA LYS J 23 13.297 72.112 117.101 1.00 28.87 C +ATOM 14877 C LYS J 23 14.737 72.568 116.995 1.00 30.75 C +ATOM 14878 O LYS J 23 15.161 73.465 117.705 1.00 26.95 O +ATOM 14879 CB LYS J 23 12.358 73.314 116.897 1.00 20.47 C +ATOM 14880 CG LYS J 23 10.858 72.986 117.228 1.00 24.09 C +ATOM 14881 CD LYS J 23 9.856 74.144 117.021 1.00 19.78 C +ATOM 14882 CE LYS J 23 8.480 73.932 117.757 1.00 16.97 C +ATOM 14883 NZ LYS J 23 7.565 72.845 117.223 1.00 14.71 N +ATOM 14884 N ALA J 24 15.487 71.916 116.115 1.00 46.19 N +ATOM 14885 CA ALA J 24 16.888 72.246 115.892 1.00 56.73 C +ATOM 14886 C ALA J 24 17.018 72.883 114.515 1.00 67.74 C +ATOM 14887 O ALA J 24 16.477 72.374 113.529 1.00 72.78 O +ATOM 14888 CB ALA J 24 17.749 70.992 115.962 1.00 64.28 C +ATOM 14889 N PRO J 25 17.675 74.046 114.439 1.00 76.41 N +ATOM 14890 CA PRO J 25 17.874 74.759 113.167 1.00 78.14 C +ATOM 14891 C PRO J 25 19.107 74.214 112.422 1.00 80.53 C +ATOM 14892 O PRO J 25 20.121 74.899 112.242 1.00 81.70 O +ATOM 14893 CB PRO J 25 18.039 76.206 113.623 1.00 81.74 C +ATOM 14894 CG PRO J 25 18.711 76.073 114.939 1.00 86.13 C +ATOM 14895 CD PRO J 25 18.079 74.871 115.597 1.00 83.38 C +ATOM 14896 N LEU J 26 19.006 72.962 111.997 1.00 80.83 N +ATOM 14897 CA LEU J 26 20.098 72.296 111.315 1.00 81.55 C +ATOM 14898 C LEU J 26 20.057 72.534 109.818 1.00 84.02 C +ATOM 14899 O LEU J 26 18.989 72.518 109.205 1.00 83.58 O +ATOM 14900 CB LEU J 26 20.060 70.804 111.638 1.00 75.88 C +ATOM 14901 CG LEU J 26 21.378 70.147 112.048 1.00 70.86 C +ATOM 14902 CD1 LEU J 26 22.235 71.071 112.904 1.00 65.35 C +ATOM 14903 CD2 LEU J 26 21.055 68.869 112.788 1.00 69.70 C +ATOM 14904 N THR J 27 21.231 72.791 109.251 1.00 87.82 N +ATOM 14905 CA THR J 27 21.387 73.053 107.820 1.00 88.74 C +ATOM 14906 C THR J 27 22.317 72.025 107.171 1.00 81.65 C +ATOM 14907 O THR J 27 22.018 71.491 106.100 1.00 80.85 O +ATOM 14908 CB THR J 27 21.967 74.472 107.574 1.00 96.40 C +ATOM 14909 OG1 THR J 27 23.125 74.667 108.406 1.00 99.88 O +ATOM 14910 CG2 THR J 27 20.917 75.551 107.875 1.00 97.25 C +ATOM 14911 N LYS J 28 23.464 71.797 107.807 1.00 75.34 N +ATOM 14912 CA LYS J 28 24.459 70.836 107.334 1.00 70.23 C +ATOM 14913 C LYS J 28 24.197 69.477 107.977 1.00 61.02 C +ATOM 14914 O LYS J 28 23.757 69.408 109.125 1.00 65.56 O +ATOM 14915 CB LYS J 28 25.873 71.292 107.723 1.00 75.28 C +ATOM 14916 CG LYS J 28 26.478 72.380 106.857 1.00 84.46 C +ATOM 14917 CD LYS J 28 26.959 71.819 105.520 1.00 96.60 C +ATOM 14918 CE LYS J 28 27.625 72.892 104.663 1.00102.70 C +ATOM 14919 NZ LYS J 28 28.148 72.348 103.375 1.00100.30 N +ATOM 14920 N PRO J 29 24.390 68.383 107.221 1.00 48.88 N +ATOM 14921 CA PRO J 29 24.173 67.042 107.763 1.00 44.12 C +ATOM 14922 C PRO J 29 25.315 66.699 108.725 1.00 38.56 C +ATOM 14923 O PRO J 29 26.452 67.124 108.513 1.00 36.15 O +ATOM 14924 CB PRO J 29 24.170 66.172 106.509 1.00 48.31 C +ATOM 14925 CG PRO J 29 25.082 66.902 105.592 1.00 47.92 C +ATOM 14926 CD PRO J 29 24.634 68.323 105.771 1.00 49.47 C +ATOM 14927 N LEU J 30 25.007 65.936 109.774 1.00 31.35 N +ATOM 14928 CA LEU J 30 25.989 65.583 110.791 1.00 23.04 C +ATOM 14929 C LEU J 30 27.013 64.507 110.427 1.00 17.83 C +ATOM 14930 O LEU J 30 26.655 63.421 109.985 1.00 8.50 O +ATOM 14931 CB LEU J 30 25.287 65.204 112.105 1.00 23.06 C +ATOM 14932 CG LEU J 30 24.491 66.210 112.960 1.00 13.29 C +ATOM 14933 CD1 LEU J 30 24.845 67.635 112.621 1.00 8.50 C +ATOM 14934 CD2 LEU J 30 23.014 65.961 112.774 1.00 8.50 C +ATOM 14935 N LYS J 31 28.282 64.823 110.681 1.00 14.69 N +ATOM 14936 CA LYS J 31 29.408 63.936 110.435 1.00 10.83 C +ATOM 14937 C LYS J 31 29.996 63.478 111.770 1.00 14.29 C +ATOM 14938 O LYS J 31 30.971 62.726 111.803 1.00 11.17 O +ATOM 14939 CB LYS J 31 30.479 64.670 109.632 1.00 26.46 C +ATOM 14940 CG LYS J 31 30.205 64.767 108.133 1.00 48.52 C +ATOM 14941 CD LYS J 31 30.289 63.393 107.478 1.00 57.64 C +ATOM 14942 CE LYS J 31 29.923 63.428 106.010 1.00 65.20 C +ATOM 14943 NZ LYS J 31 29.976 62.063 105.408 1.00 72.99 N +ATOM 14944 N ALA J 32 29.416 63.986 112.860 1.00 17.36 N +ATOM 14945 CA ALA J 32 29.797 63.692 114.245 1.00 8.50 C +ATOM 14946 C ALA J 32 28.795 64.413 115.127 1.00 8.50 C +ATOM 14947 O ALA J 32 28.043 65.244 114.642 1.00 11.80 O +ATOM 14948 CB ALA J 32 31.185 64.194 114.533 1.00 8.50 C +ATOM 14949 N PHE J 33 28.749 64.075 116.404 1.00 8.50 N +ATOM 14950 CA PHE J 33 27.822 64.725 117.327 1.00 11.14 C +ATOM 14951 C PHE J 33 28.035 64.252 118.765 1.00 13.85 C +ATOM 14952 O PHE J 33 28.654 63.220 118.987 1.00 16.91 O +ATOM 14953 CB PHE J 33 26.355 64.491 116.909 1.00 8.50 C +ATOM 14954 CG PHE J 33 25.911 63.055 116.984 1.00 11.27 C +ATOM 14955 CD1 PHE J 33 25.372 62.538 118.150 1.00 16.73 C +ATOM 14956 CD2 PHE J 33 25.979 62.231 115.874 1.00 12.56 C +ATOM 14957 CE1 PHE J 33 24.907 61.221 118.201 1.00 13.42 C +ATOM 14958 CE2 PHE J 33 25.513 60.919 115.929 1.00 8.50 C +ATOM 14959 CZ PHE J 33 24.980 60.420 117.086 1.00 8.50 C +ATOM 14960 N THR J 34 27.557 65.031 119.729 1.00 10.21 N +ATOM 14961 CA THR J 34 27.648 64.687 121.133 1.00 8.50 C +ATOM 14962 C THR J 34 26.327 65.143 121.691 1.00 8.50 C +ATOM 14963 O THR J 34 25.889 66.239 121.406 1.00 10.52 O +ATOM 14964 CB THR J 34 28.735 65.475 121.864 1.00 8.50 C +ATOM 14965 OG1 THR J 34 30.005 65.299 121.219 1.00 8.50 O +ATOM 14966 CG2 THR J 34 28.825 65.028 123.309 1.00 8.50 C +ATOM 14967 N VAL J 35 25.642 64.277 122.408 1.00 8.50 N +ATOM 14968 CA VAL J 35 24.372 64.646 123.019 1.00 8.50 C +ATOM 14969 C VAL J 35 24.417 64.199 124.472 1.00 8.50 C +ATOM 14970 O VAL J 35 24.789 63.076 124.763 1.00 8.50 O +ATOM 14971 CB VAL J 35 23.126 64.082 122.258 1.00 8.50 C +ATOM 14972 CG1 VAL J 35 23.514 62.934 121.361 1.00 17.21 C +ATOM 14973 CG2 VAL J 35 22.040 63.646 123.223 1.00 8.50 C +ATOM 14974 N CYS J 36 24.163 65.133 125.377 1.00 8.71 N +ATOM 14975 CA CYS J 36 24.176 64.866 126.797 1.00 8.50 C +ATOM 14976 C CYS J 36 22.807 65.196 127.336 1.00 8.50 C +ATOM 14977 O CYS J 36 22.105 66.022 126.778 1.00 8.50 O +ATOM 14978 CB CYS J 36 25.198 65.744 127.489 1.00 8.50 C +ATOM 14979 SG CYS J 36 26.898 65.578 126.904 1.00 8.50 S +ATOM 14980 N LEU J 37 22.407 64.515 128.399 1.00 8.50 N +ATOM 14981 CA LEU J 37 21.111 64.738 129.023 1.00 8.50 C +ATOM 14982 C LEU J 37 21.049 64.118 130.413 1.00 8.50 C +ATOM 14983 O LEU J 37 21.912 63.321 130.790 1.00 8.59 O +ATOM 14984 CB LEU J 37 19.988 64.204 128.132 1.00 8.50 C +ATOM 14985 CG LEU J 37 19.924 62.737 127.741 1.00 8.50 C +ATOM 14986 CD1 LEU J 37 19.167 61.952 128.760 1.00 8.50 C +ATOM 14987 CD2 LEU J 37 19.231 62.635 126.431 1.00 8.50 C +ATOM 14988 N HIS J 38 20.045 64.512 131.183 1.00 8.50 N +ATOM 14989 CA HIS J 38 19.842 64.023 132.534 1.00 8.50 C +ATOM 14990 C HIS J 38 18.457 63.399 132.535 1.00 8.90 C +ATOM 14991 O HIS J 38 17.516 64.007 132.027 1.00 13.99 O +ATOM 14992 CB HIS J 38 19.806 65.220 133.469 1.00 8.91 C +ATOM 14993 CG HIS J 38 20.854 65.223 134.541 1.00 14.07 C +ATOM 14994 ND1 HIS J 38 21.806 66.215 134.643 1.00 8.50 N +ATOM 14995 CD2 HIS J 38 21.051 64.403 135.600 1.00 9.77 C +ATOM 14996 CE1 HIS J 38 22.545 66.002 135.716 1.00 14.50 C +ATOM 14997 NE2 HIS J 38 22.107 64.909 136.315 1.00 9.83 N +ATOM 14998 N PHE J 39 18.311 62.192 133.066 1.00 8.50 N +ATOM 14999 CA PHE J 39 16.984 61.578 133.126 1.00 8.50 C +ATOM 15000 C PHE J 39 16.835 60.863 134.456 1.00 8.50 C +ATOM 15001 O PHE J 39 17.820 60.584 135.124 1.00 8.50 O +ATOM 15002 CB PHE J 39 16.705 60.649 131.921 1.00 10.02 C +ATOM 15003 CG PHE J 39 17.456 59.334 131.940 1.00 8.50 C +ATOM 15004 CD1 PHE J 39 18.764 59.249 131.487 1.00 8.50 C +ATOM 15005 CD2 PHE J 39 16.846 58.184 132.416 1.00 8.50 C +ATOM 15006 CE1 PHE J 39 19.452 58.040 131.512 1.00 8.50 C +ATOM 15007 CE2 PHE J 39 17.523 56.973 132.446 1.00 8.50 C +ATOM 15008 CZ PHE J 39 18.829 56.902 131.994 1.00 10.04 C +ATOM 15009 N TYR J 40 15.609 60.617 134.868 1.00 8.50 N +ATOM 15010 CA TYR J 40 15.377 59.960 136.128 1.00 8.50 C +ATOM 15011 C TYR J 40 14.083 59.204 136.041 1.00 8.50 C +ATOM 15012 O TYR J 40 13.017 59.812 136.062 1.00 11.40 O +ATOM 15013 CB TYR J 40 15.272 61.003 137.227 1.00 8.50 C +ATOM 15014 CG TYR J 40 15.055 60.457 138.611 1.00 8.50 C +ATOM 15015 CD1 TYR J 40 15.473 59.175 138.950 1.00 8.50 C +ATOM 15016 CD2 TYR J 40 14.446 61.232 139.589 1.00 16.19 C +ATOM 15017 CE1 TYR J 40 15.296 58.671 140.210 1.00 8.50 C +ATOM 15018 CE2 TYR J 40 14.259 60.735 140.877 1.00 25.71 C +ATOM 15019 CZ TYR J 40 14.691 59.444 141.179 1.00 19.80 C +ATOM 15020 OH TYR J 40 14.536 58.929 142.450 1.00 17.65 O +ATOM 15021 N THR J 41 14.169 57.875 135.976 1.00 14.07 N +ATOM 15022 CA THR J 41 12.983 57.023 135.878 1.00 13.48 C +ATOM 15023 C THR J 41 13.058 55.768 136.748 1.00 18.18 C +ATOM 15024 O THR J 41 14.139 55.379 137.217 1.00 17.11 O +ATOM 15025 CB THR J 41 12.730 56.599 134.444 1.00 8.50 C +ATOM 15026 OG1 THR J 41 11.498 55.869 134.388 1.00 14.02 O +ATOM 15027 CG2 THR J 41 13.885 55.751 133.937 1.00 8.50 C +ATOM 15028 N GLU J 42 11.909 55.117 136.914 1.00 21.49 N +ATOM 15029 CA GLU J 42 11.840 53.931 137.734 1.00 29.39 C +ATOM 15030 C GLU J 42 11.839 52.572 137.039 1.00 34.38 C +ATOM 15031 O GLU J 42 11.058 51.697 137.335 1.00 42.57 O +ATOM 15032 CB GLU J 42 10.722 54.053 138.780 1.00 39.74 C +ATOM 15033 CG GLU J 42 11.076 53.501 140.182 1.00 44.52 C +ATOM 15034 CD GLU J 42 10.151 54.050 141.272 1.00 52.32 C +ATOM 15035 OE1 GLU J 42 9.037 53.510 141.469 1.00 45.80 O +ATOM 15036 OE2 GLU J 42 10.536 55.044 141.926 1.00 62.62 O +ATOM 15037 N LEU J 43 13.086 52.276 136.655 1.00 45.72 N +ATOM 15038 CA LEU J 43 13.494 50.994 136.051 1.00 58.97 C +ATOM 15039 C LEU J 43 12.568 49.810 136.446 1.00 63.27 C +ATOM 15040 O LEU J 43 12.817 49.094 137.429 1.00 55.78 O +ATOM 15041 CB LEU J 43 14.945 50.700 136.497 1.00 64.81 C +ATOM 15042 CG LEU J 43 15.363 51.060 137.935 1.00 62.90 C +ATOM 15043 CD1 LEU J 43 15.525 49.784 138.748 1.00 66.38 C +ATOM 15044 CD2 LEU J 43 16.665 51.879 137.938 1.00 60.54 C +ATOM 15045 N SER J 44 11.496 49.634 135.679 1.00 71.81 N +ATOM 15046 CA SER J 44 10.500 48.603 135.963 1.00 76.77 C +ATOM 15047 C SER J 44 10.642 47.350 135.110 1.00 79.09 C +ATOM 15048 O SER J 44 11.754 46.867 134.873 1.00 74.46 O +ATOM 15049 CB SER J 44 9.083 49.195 135.817 1.00 79.50 C +ATOM 15050 OG SER J 44 8.788 49.518 134.460 1.00 83.98 O +ATOM 15051 N SER J 45 9.498 46.847 134.648 1.00 84.42 N +ATOM 15052 CA SER J 45 9.405 45.651 133.825 1.00 88.50 C +ATOM 15053 C SER J 45 10.377 45.676 132.646 1.00 94.10 C +ATOM 15054 O SER J 45 11.054 46.688 132.382 1.00 99.07 O +ATOM 15055 CB SER J 45 7.969 45.503 133.298 1.00 83.99 C +ATOM 15056 OG SER J 45 7.011 45.835 134.297 1.00 79.59 O +ATOM 15057 N THR J 46 10.421 44.555 131.930 1.00 95.56 N +ATOM 15058 CA THR J 46 11.281 44.409 130.755 1.00 95.64 C +ATOM 15059 C THR J 46 11.060 45.581 129.755 1.00 95.51 C +ATOM 15060 O THR J 46 11.961 45.936 128.975 1.00 96.93 O +ATOM 15061 CB THR J 46 11.062 42.996 130.106 1.00 94.75 C +ATOM 15062 OG1 THR J 46 11.861 42.011 130.791 1.00 78.17 O +ATOM 15063 CG2 THR J 46 11.375 43.005 128.627 1.00 89.83 C +ATOM 15064 N ARG J 47 9.873 46.193 129.820 1.00 89.07 N +ATOM 15065 CA ARG J 47 9.526 47.330 128.972 1.00 72.29 C +ATOM 15066 C ARG J 47 10.367 48.562 129.323 1.00 56.00 C +ATOM 15067 O ARG J 47 10.183 49.212 130.371 1.00 25.74 O +ATOM 15068 CB ARG J 47 8.014 47.633 129.030 1.00 78.84 C +ATOM 15069 CG ARG J 47 7.342 47.361 130.382 1.00 94.55 C +ATOM 15070 CD ARG J 47 6.920 48.640 131.121 1.00107.85 C +ATOM 15071 NE ARG J 47 5.464 48.832 131.123 1.00114.64 N +ATOM 15072 CZ ARG J 47 4.719 49.004 132.217 1.00113.18 C +ATOM 15073 NH1 ARG J 47 5.278 49.013 133.424 1.00113.48 N +ATOM 15074 NH2 ARG J 47 3.404 49.171 132.104 1.00112.81 N +ATOM 15075 N GLY J 48 11.370 48.778 128.472 1.00 48.29 N +ATOM 15076 CA GLY J 48 12.270 49.906 128.604 1.00 31.22 C +ATOM 15077 C GLY J 48 11.643 51.137 127.970 1.00 24.84 C +ATOM 15078 O GLY J 48 10.546 51.109 127.394 1.00 20.81 O +ATOM 15079 N TYR J 49 12.364 52.233 128.047 1.00 18.65 N +ATOM 15080 CA TYR J 49 11.862 53.466 127.523 1.00 9.09 C +ATOM 15081 C TYR J 49 12.868 54.060 126.597 1.00 12.23 C +ATOM 15082 O TYR J 49 14.077 53.775 126.669 1.00 10.56 O +ATOM 15083 CB TYR J 49 11.668 54.470 128.658 1.00 8.50 C +ATOM 15084 CG TYR J 49 10.674 54.058 129.699 1.00 8.50 C +ATOM 15085 CD1 TYR J 49 9.328 53.865 129.363 1.00 8.50 C +ATOM 15086 CD2 TYR J 49 11.069 53.855 131.019 1.00 8.50 C +ATOM 15087 CE1 TYR J 49 8.393 53.480 130.314 1.00 8.50 C +ATOM 15088 CE2 TYR J 49 10.143 53.463 131.987 1.00 8.50 C +ATOM 15089 CZ TYR J 49 8.804 53.276 131.626 1.00 8.53 C +ATOM 15090 OH TYR J 49 7.891 52.835 132.560 1.00 8.50 O +ATOM 15091 N SER J 50 12.337 54.878 125.707 1.00 15.02 N +ATOM 15092 CA SER J 50 13.136 55.638 124.781 1.00 22.67 C +ATOM 15093 C SER J 50 13.584 56.917 125.515 1.00 27.84 C +ATOM 15094 O SER J 50 12.771 57.624 126.122 1.00 34.83 O +ATOM 15095 CB SER J 50 12.298 56.001 123.572 1.00 22.69 C +ATOM 15096 OG SER J 50 12.992 56.935 122.775 1.00 49.07 O +ATOM 15097 N ILE J 51 14.877 57.204 125.466 1.00 25.43 N +ATOM 15098 CA ILE J 51 15.408 58.391 126.124 1.00 14.97 C +ATOM 15099 C ILE J 51 15.495 59.565 125.132 1.00 18.66 C +ATOM 15100 O ILE J 51 14.941 60.623 125.374 1.00 18.46 O +ATOM 15101 CB ILE J 51 16.779 58.087 126.722 1.00 10.76 C +ATOM 15102 CG1 ILE J 51 16.650 57.012 127.794 1.00 15.58 C +ATOM 15103 CG2 ILE J 51 17.367 59.304 127.307 1.00 8.50 C +ATOM 15104 CD1 ILE J 51 17.998 56.493 128.299 1.00 28.03 C +ATOM 15105 N PHE J 52 16.127 59.344 123.980 1.00 19.35 N +ATOM 15106 CA PHE J 52 16.304 60.379 122.960 1.00 8.50 C +ATOM 15107 C PHE J 52 16.061 59.763 121.585 1.00 12.48 C +ATOM 15108 O PHE J 52 16.721 58.789 121.221 1.00 17.64 O +ATOM 15109 CB PHE J 52 17.747 60.875 123.038 1.00 11.22 C +ATOM 15110 CG PHE J 52 18.039 62.070 122.177 1.00 14.36 C +ATOM 15111 CD1 PHE J 52 17.586 63.333 122.544 1.00 20.90 C +ATOM 15112 CD2 PHE J 52 18.804 61.950 121.032 1.00 8.50 C +ATOM 15113 CE1 PHE J 52 17.892 64.451 121.785 1.00 8.50 C +ATOM 15114 CE2 PHE J 52 19.113 63.058 120.276 1.00 8.50 C +ATOM 15115 CZ PHE J 52 18.657 64.312 120.649 1.00 8.50 C +ATOM 15116 N SER J 53 15.137 60.335 120.818 1.00 15.04 N +ATOM 15117 CA SER J 53 14.799 59.835 119.476 1.00 14.00 C +ATOM 15118 C SER J 53 14.946 60.876 118.375 1.00 8.50 C +ATOM 15119 O SER J 53 14.140 61.756 118.266 1.00 8.50 O +ATOM 15120 CB SER J 53 13.362 59.297 119.460 1.00 17.78 C +ATOM 15121 OG SER J 53 13.077 58.604 118.249 1.00 31.51 O +ATOM 15122 N TYR J 54 15.971 60.740 117.551 1.00 8.64 N +ATOM 15123 CA TYR J 54 16.257 61.647 116.439 1.00 10.77 C +ATOM 15124 C TYR J 54 15.912 60.903 115.151 1.00 24.36 C +ATOM 15125 O TYR J 54 16.637 59.986 114.743 1.00 29.33 O +ATOM 15126 CB TYR J 54 17.742 61.968 116.442 1.00 10.32 C +ATOM 15127 CG TYR J 54 18.212 63.002 115.435 1.00 19.11 C +ATOM 15128 CD1 TYR J 54 18.542 62.642 114.135 1.00 18.60 C +ATOM 15129 CD2 TYR J 54 18.419 64.328 115.811 1.00 17.69 C +ATOM 15130 CE1 TYR J 54 19.077 63.571 113.249 1.00 8.50 C +ATOM 15131 CE2 TYR J 54 18.942 65.254 114.934 1.00 8.50 C +ATOM 15132 CZ TYR J 54 19.271 64.868 113.658 1.00 8.50 C +ATOM 15133 OH TYR J 54 19.806 65.775 112.781 1.00 8.50 O +ATOM 15134 N ALA J 55 14.834 61.317 114.494 1.00 29.14 N +ATOM 15135 CA ALA J 55 14.373 60.648 113.285 1.00 32.66 C +ATOM 15136 C ALA J 55 14.369 61.497 112.018 1.00 34.57 C +ATOM 15137 O ALA J 55 14.158 62.700 112.075 1.00 32.16 O +ATOM 15138 CB ALA J 55 12.966 60.068 113.527 1.00 31.89 C +ATOM 15139 N THR J 56 14.566 60.831 110.878 1.00 41.16 N +ATOM 15140 CA THR J 56 14.565 61.443 109.548 1.00 37.98 C +ATOM 15141 C THR J 56 13.428 60.791 108.752 1.00 45.53 C +ATOM 15142 O THR J 56 12.898 59.736 109.132 1.00 48.14 O +ATOM 15143 CB THR J 56 15.850 61.131 108.768 1.00 31.36 C +ATOM 15144 OG1 THR J 56 16.987 61.219 109.629 1.00 31.17 O +ATOM 15145 CG2 THR J 56 16.022 62.096 107.628 1.00 30.32 C +ATOM 15146 N LYS J 57 13.073 61.409 107.632 1.00 50.91 N +ATOM 15147 CA LYS J 57 12.027 60.892 106.745 1.00 51.64 C +ATOM 15148 C LYS J 57 12.449 59.524 106.235 1.00 50.05 C +ATOM 15149 O LYS J 57 11.670 58.572 106.238 1.00 55.30 O +ATOM 15150 CB LYS J 57 11.852 61.831 105.540 1.00 55.03 C +ATOM 15151 CG LYS J 57 10.943 63.039 105.771 1.00 62.97 C +ATOM 15152 CD LYS J 57 11.224 63.756 107.103 1.00 78.39 C +ATOM 15153 CE LYS J 57 12.376 64.734 107.015 1.00 85.85 C +ATOM 15154 NZ LYS J 57 13.588 64.125 106.391 1.00 96.35 N +ATOM 15155 N ARG J 58 13.712 59.443 105.829 1.00 47.03 N +ATOM 15156 CA ARG J 58 14.290 58.214 105.310 1.00 47.21 C +ATOM 15157 C ARG J 58 14.617 57.145 106.370 1.00 44.30 C +ATOM 15158 O ARG J 58 14.457 55.957 106.118 1.00 46.64 O +ATOM 15159 CB ARG J 58 15.519 58.556 104.465 1.00 63.93 C +ATOM 15160 CG ARG J 58 16.265 57.356 103.853 1.00 90.41 C +ATOM 15161 CD ARG J 58 17.297 56.729 104.819 1.00104.95 C +ATOM 15162 NE ARG J 58 18.250 57.721 105.323 1.00115.09 N +ATOM 15163 CZ ARG J 58 19.160 57.497 106.268 1.00113.66 C +ATOM 15164 NH1 ARG J 58 19.267 56.296 106.834 1.00111.28 N +ATOM 15165 NH2 ARG J 58 19.943 58.497 106.663 1.00107.58 N +ATOM 15166 N GLN J 59 15.063 57.567 107.549 1.00 39.65 N +ATOM 15167 CA GLN J 59 15.428 56.646 108.616 1.00 30.96 C +ATOM 15168 C GLN J 59 14.796 57.113 109.913 1.00 27.64 C +ATOM 15169 O GLN J 59 15.179 58.131 110.455 1.00 33.99 O +ATOM 15170 CB GLN J 59 16.946 56.601 108.738 1.00 21.35 C +ATOM 15171 CG GLN J 59 17.495 55.879 109.939 1.00 22.55 C +ATOM 15172 CD GLN J 59 17.077 54.441 110.011 1.00 24.67 C +ATOM 15173 OE1 GLN J 59 15.998 54.123 110.519 1.00 34.56 O +ATOM 15174 NE2 GLN J 59 17.930 53.553 109.525 1.00 28.48 N +ATOM 15175 N ASP J 60 13.865 56.333 110.437 1.00 28.61 N +ATOM 15176 CA ASP J 60 13.160 56.684 111.669 1.00 30.09 C +ATOM 15177 C ASP J 60 14.061 56.637 112.920 1.00 25.00 C +ATOM 15178 O ASP J 60 13.803 57.315 113.918 1.00 28.83 O +ATOM 15179 CB ASP J 60 11.912 55.781 111.833 1.00 44.35 C +ATOM 15180 CG ASP J 60 12.268 54.255 111.948 1.00 62.25 C +ATOM 15181 OD1 ASP J 60 13.014 53.720 111.075 1.00 69.82 O +ATOM 15182 OD2 ASP J 60 11.830 53.600 112.939 1.00 57.12 O +ATOM 15183 N ASN J 61 15.107 55.825 112.877 1.00 14.64 N +ATOM 15184 CA ASN J 61 16.007 55.727 114.007 1.00 9.74 C +ATOM 15185 C ASN J 61 17.395 56.166 113.598 1.00 8.50 C +ATOM 15186 O ASN J 61 18.334 55.376 113.599 1.00 9.12 O +ATOM 15187 CB ASN J 61 16.041 54.302 114.547 1.00 18.35 C +ATOM 15188 CG ASN J 61 14.711 53.866 115.181 1.00 36.73 C +ATOM 15189 OD1 ASN J 61 14.441 52.673 115.268 1.00 52.71 O +ATOM 15190 ND2 ASN J 61 13.904 54.817 115.658 1.00 23.30 N +ATOM 15191 N GLU J 62 17.513 57.440 113.241 1.00 10.50 N +ATOM 15192 CA GLU J 62 18.779 58.022 112.812 1.00 8.50 C +ATOM 15193 C GLU J 62 19.791 58.021 113.946 1.00 8.50 C +ATOM 15194 O GLU J 62 20.952 57.726 113.741 1.00 14.73 O +ATOM 15195 CB GLU J 62 18.551 59.430 112.271 1.00 8.50 C +ATOM 15196 CG GLU J 62 19.710 59.987 111.463 1.00 18.44 C +ATOM 15197 CD GLU J 62 19.941 59.255 110.151 1.00 19.49 C +ATOM 15198 OE1 GLU J 62 20.169 58.041 110.173 1.00 19.79 O +ATOM 15199 OE2 GLU J 62 19.908 59.891 109.086 1.00 27.73 O +ATOM 15200 N ILE J 63 19.363 58.446 115.122 1.00 11.22 N +ATOM 15201 CA ILE J 63 20.191 58.414 116.318 1.00 9.63 C +ATOM 15202 C ILE J 63 19.167 58.210 117.433 1.00 8.50 C +ATOM 15203 O ILE J 63 18.184 58.916 117.496 1.00 8.50 O +ATOM 15204 CB ILE J 63 21.129 59.662 116.501 1.00 8.50 C +ATOM 15205 CG1 ILE J 63 21.077 60.190 117.919 1.00 8.50 C +ATOM 15206 CG2 ILE J 63 20.862 60.734 115.519 1.00 14.21 C +ATOM 15207 CD1 ILE J 63 21.810 59.332 118.891 1.00 16.09 C +ATOM 15208 N LEU J 64 19.322 57.137 118.199 1.00 8.83 N +ATOM 15209 CA LEU J 64 18.405 56.807 119.280 1.00 8.53 C +ATOM 15210 C LEU J 64 19.094 56.202 120.518 1.00 12.77 C +ATOM 15211 O LEU J 64 19.941 55.304 120.400 1.00 17.47 O +ATOM 15212 CB LEU J 64 17.338 55.861 118.752 1.00 8.50 C +ATOM 15213 CG LEU J 64 16.438 55.162 119.764 1.00 8.50 C +ATOM 15214 CD1 LEU J 64 15.010 55.588 119.636 1.00 8.50 C +ATOM 15215 CD2 LEU J 64 16.527 53.690 119.520 1.00 19.12 C +ATOM 15216 N ILE J 65 18.771 56.753 121.690 1.00 9.07 N +ATOM 15217 CA ILE J 65 19.304 56.302 122.971 1.00 11.51 C +ATOM 15218 C ILE J 65 18.140 55.603 123.665 1.00 16.16 C +ATOM 15219 O ILE J 65 17.095 56.213 123.930 1.00 8.50 O +ATOM 15220 CB ILE J 65 19.785 57.468 123.833 1.00 8.50 C +ATOM 15221 CG1 ILE J 65 20.888 58.213 123.083 1.00 8.89 C +ATOM 15222 CG2 ILE J 65 20.294 56.928 125.166 1.00 8.50 C +ATOM 15223 CD1 ILE J 65 21.308 59.487 123.703 1.00 8.50 C +ATOM 15224 N PHE J 66 18.341 54.332 124.000 1.00 18.61 N +ATOM 15225 CA PHE J 66 17.286 53.535 124.594 1.00 15.27 C +ATOM 15226 C PHE J 66 17.815 52.746 125.759 1.00 12.53 C +ATOM 15227 O PHE J 66 18.920 52.197 125.709 1.00 11.71 O +ATOM 15228 CB PHE J 66 16.764 52.593 123.524 1.00 29.73 C +ATOM 15229 CG PHE J 66 15.469 51.912 123.874 1.00 38.96 C +ATOM 15230 CD1 PHE J 66 14.243 52.486 123.520 1.00 46.59 C +ATOM 15231 CD2 PHE J 66 15.474 50.664 124.491 1.00 32.76 C +ATOM 15232 CE1 PHE J 66 13.045 51.820 123.771 1.00 46.03 C +ATOM 15233 CE2 PHE J 66 14.290 49.994 124.745 1.00 34.08 C +ATOM 15234 CZ PHE J 66 13.071 50.570 124.384 1.00 42.69 C +ATOM 15235 N TRP J 67 17.066 52.816 126.848 1.00 8.50 N +ATOM 15236 CA TRP J 67 17.457 52.143 128.061 1.00 11.59 C +ATOM 15237 C TRP J 67 16.346 51.271 128.631 1.00 20.13 C +ATOM 15238 O TRP J 67 15.189 51.699 128.785 1.00 15.62 O +ATOM 15239 CB TRP J 67 17.928 53.186 129.096 1.00 17.75 C +ATOM 15240 CG TRP J 67 18.105 52.670 130.504 1.00 16.83 C +ATOM 15241 CD1 TRP J 67 19.262 52.204 131.089 1.00 16.87 C +ATOM 15242 CD2 TRP J 67 17.073 52.487 131.468 1.00 17.79 C +ATOM 15243 NE1 TRP J 67 19.003 51.728 132.352 1.00 8.50 N +ATOM 15244 CE2 TRP J 67 17.668 51.887 132.613 1.00 14.30 C +ATOM 15245 CE3 TRP J 67 15.697 52.758 131.474 1.00 9.87 C +ATOM 15246 CZ2 TRP J 67 16.931 51.554 133.746 1.00 8.50 C +ATOM 15247 CZ3 TRP J 67 14.966 52.426 132.601 1.00 25.10 C +ATOM 15248 CH2 TRP J 67 15.589 51.829 133.723 1.00 20.87 C +ATOM 15249 N SER J 68 16.715 50.030 128.919 1.00 21.37 N +ATOM 15250 CA SER J 68 15.812 49.068 129.516 1.00 26.96 C +ATOM 15251 C SER J 68 16.597 48.539 130.708 1.00 27.21 C +ATOM 15252 O SER J 68 17.823 48.380 130.623 1.00 18.35 O +ATOM 15253 CB SER J 68 15.504 47.928 128.541 1.00 43.95 C +ATOM 15254 OG SER J 68 14.715 46.912 129.156 1.00 49.13 O +ATOM 15255 N LYS J 69 15.891 48.292 131.812 1.00 30.10 N +ATOM 15256 CA LYS J 69 16.484 47.782 133.050 1.00 29.03 C +ATOM 15257 C LYS J 69 17.417 46.596 132.825 1.00 32.58 C +ATOM 15258 O LYS J 69 18.617 46.676 133.109 1.00 24.51 O +ATOM 15259 CB LYS J 69 15.384 47.338 134.021 1.00 34.02 C +ATOM 15260 CG LYS J 69 15.919 46.691 135.297 1.00 33.75 C +ATOM 15261 CD LYS J 69 14.826 45.995 136.118 1.00 53.10 C +ATOM 15262 CE LYS J 69 14.402 44.633 135.530 1.00 55.49 C +ATOM 15263 NZ LYS J 69 13.624 43.796 136.510 1.00 33.59 N +ATOM 15264 N ASP J 70 16.836 45.498 132.332 1.00 39.00 N +ATOM 15265 CA ASP J 70 17.543 44.241 132.063 1.00 34.88 C +ATOM 15266 C ASP J 70 18.207 44.141 130.689 1.00 31.42 C +ATOM 15267 O ASP J 70 18.259 43.065 130.097 1.00 36.96 O +ATOM 15268 CB ASP J 70 16.616 43.033 132.323 1.00 35.38 C +ATOM 15269 CG ASP J 70 15.195 43.230 131.784 1.00 47.07 C +ATOM 15270 OD1 ASP J 70 15.028 43.864 130.714 1.00 53.99 O +ATOM 15271 OD2 ASP J 70 14.241 42.737 132.435 1.00 42.85 O +ATOM 15272 N ILE J 71 18.746 45.264 130.213 1.00 35.34 N +ATOM 15273 CA ILE J 71 19.427 45.347 128.920 1.00 27.22 C +ATOM 15274 C ILE J 71 20.629 46.248 129.051 1.00 22.14 C +ATOM 15275 O ILE J 71 21.752 45.835 128.744 1.00 15.11 O +ATOM 15276 CB ILE J 71 18.499 45.916 127.813 1.00 21.19 C +ATOM 15277 CG1 ILE J 71 17.422 44.883 127.472 1.00 26.07 C +ATOM 15278 CG2 ILE J 71 19.300 46.283 126.570 1.00 11.82 C +ATOM 15279 CD1 ILE J 71 16.556 45.246 126.327 1.00 23.52 C +ATOM 15280 N GLY J 72 20.369 47.460 129.550 1.00 21.28 N +ATOM 15281 CA GLY J 72 21.395 48.473 129.728 1.00 8.89 C +ATOM 15282 C GLY J 72 21.140 49.564 128.713 1.00 8.50 C +ATOM 15283 O GLY J 72 19.986 49.845 128.373 1.00 8.50 O +ATOM 15284 N TYR J 73 22.200 50.162 128.195 1.00 8.50 N +ATOM 15285 CA TYR J 73 22.029 51.211 127.221 1.00 8.50 C +ATOM 15286 C TYR J 73 22.203 50.737 125.809 1.00 8.50 C +ATOM 15287 O TYR J 73 23.197 50.106 125.477 1.00 11.41 O +ATOM 15288 CB TYR J 73 22.983 52.350 127.510 1.00 8.50 C +ATOM 15289 CG TYR J 73 22.676 53.043 128.803 1.00 8.50 C +ATOM 15290 CD1 TYR J 73 21.573 53.905 128.919 1.00 8.50 C +ATOM 15291 CD2 TYR J 73 23.447 52.797 129.930 1.00 8.50 C +ATOM 15292 CE1 TYR J 73 21.247 54.498 130.141 1.00 15.28 C +ATOM 15293 CE2 TYR J 73 23.134 53.375 131.153 1.00 14.87 C +ATOM 15294 CZ TYR J 73 22.033 54.223 131.259 1.00 22.28 C +ATOM 15295 OH TYR J 73 21.725 54.782 132.485 1.00 28.44 O +ATOM 15296 N SER J 74 21.233 51.087 124.978 1.00 8.50 N +ATOM 15297 CA SER J 74 21.207 50.714 123.580 1.00 9.28 C +ATOM 15298 C SER J 74 21.367 51.968 122.756 1.00 9.15 C +ATOM 15299 O SER J 74 20.435 52.752 122.630 1.00 12.38 O +ATOM 15300 CB SER J 74 19.866 50.060 123.267 1.00 8.50 C +ATOM 15301 OG SER J 74 19.702 49.852 121.887 1.00 22.39 O +ATOM 15302 N PHE J 75 22.559 52.174 122.224 1.00 8.50 N +ATOM 15303 CA PHE J 75 22.829 53.351 121.419 1.00 8.50 C +ATOM 15304 C PHE J 75 22.801 52.968 119.955 1.00 9.91 C +ATOM 15305 O PHE J 75 23.643 52.194 119.506 1.00 15.14 O +ATOM 15306 CB PHE J 75 24.204 53.928 121.776 1.00 14.82 C +ATOM 15307 CG PHE J 75 24.588 55.127 120.960 1.00 9.80 C +ATOM 15308 CD1 PHE J 75 23.845 56.278 121.025 1.00 8.50 C +ATOM 15309 CD2 PHE J 75 25.668 55.088 120.107 1.00 8.50 C +ATOM 15310 CE1 PHE J 75 24.172 57.356 120.254 1.00 8.91 C +ATOM 15311 CE2 PHE J 75 25.993 56.175 119.334 1.00 8.50 C +ATOM 15312 CZ PHE J 75 25.248 57.308 119.406 1.00 8.50 C +ATOM 15313 N THR J 76 21.870 53.541 119.202 1.00 9.19 N +ATOM 15314 CA THR J 76 21.741 53.234 117.783 1.00 10.32 C +ATOM 15315 C THR J 76 21.806 54.454 116.872 1.00 8.50 C +ATOM 15316 O THR J 76 21.144 55.434 117.111 1.00 11.90 O +ATOM 15317 CB THR J 76 20.456 52.389 117.518 1.00 9.99 C +ATOM 15318 OG1 THR J 76 19.813 52.804 116.314 1.00 8.50 O +ATOM 15319 CG2 THR J 76 19.487 52.484 118.672 1.00 8.50 C +ATOM 15320 N VAL J 77 22.668 54.416 115.869 1.00 8.50 N +ATOM 15321 CA VAL J 77 22.797 55.509 114.927 1.00 12.05 C +ATOM 15322 C VAL J 77 22.724 54.947 113.513 1.00 19.71 C +ATOM 15323 O VAL J 77 23.440 54.020 113.173 1.00 26.94 O +ATOM 15324 CB VAL J 77 24.103 56.341 115.138 1.00 8.50 C +ATOM 15325 CG1 VAL J 77 25.228 55.498 115.596 1.00 8.50 C +ATOM 15326 CG2 VAL J 77 24.511 57.029 113.851 1.00 8.50 C +ATOM 15327 N GLY J 78 21.794 55.459 112.719 1.00 20.24 N +ATOM 15328 CA GLY J 78 21.641 55.008 111.355 1.00 16.26 C +ATOM 15329 C GLY J 78 21.010 53.640 111.278 1.00 20.79 C +ATOM 15330 O GLY J 78 21.356 52.840 110.404 1.00 32.63 O +ATOM 15331 N GLY J 79 20.085 53.360 112.185 1.00 17.72 N +ATOM 15332 CA GLY J 79 19.431 52.062 112.181 1.00 18.69 C +ATOM 15333 C GLY J 79 20.245 50.908 112.754 1.00 18.89 C +ATOM 15334 O GLY J 79 19.692 49.833 113.006 1.00 18.38 O +ATOM 15335 N SER J 80 21.549 51.115 112.941 1.00 19.26 N +ATOM 15336 CA SER J 80 22.433 50.094 113.500 1.00 22.86 C +ATOM 15337 C SER J 80 22.651 50.304 115.014 1.00 23.44 C +ATOM 15338 O SER J 80 23.095 51.364 115.449 1.00 31.84 O +ATOM 15339 CB SER J 80 23.763 50.054 112.740 1.00 20.26 C +ATOM 15340 OG SER J 80 23.569 49.617 111.401 1.00 27.55 O +ATOM 15341 N GLU J 81 22.341 49.270 115.794 1.00 17.55 N +ATOM 15342 CA GLU J 81 22.434 49.272 117.246 1.00 8.50 C +ATOM 15343 C GLU J 81 23.768 48.770 117.802 1.00 9.39 C +ATOM 15344 O GLU J 81 24.529 48.083 117.121 1.00 16.44 O +ATOM 15345 CB GLU J 81 21.285 48.431 117.771 1.00 8.50 C +ATOM 15346 CG GLU J 81 21.187 48.255 119.253 1.00 22.42 C +ATOM 15347 CD GLU J 81 20.205 47.141 119.645 1.00 35.05 C +ATOM 15348 OE1 GLU J 81 20.477 45.968 119.317 1.00 47.02 O +ATOM 15349 OE2 GLU J 81 19.172 47.423 120.293 1.00 38.07 O +ATOM 15350 N ILE J 82 24.047 49.156 119.040 1.00 8.50 N +ATOM 15351 CA ILE J 82 25.262 48.788 119.751 1.00 8.50 C +ATOM 15352 C ILE J 82 24.876 48.798 121.225 1.00 8.60 C +ATOM 15353 O ILE J 82 23.987 49.546 121.629 1.00 8.50 O +ATOM 15354 CB ILE J 82 26.422 49.746 119.454 1.00 8.50 C +ATOM 15355 CG1 ILE J 82 27.748 49.037 119.648 1.00 8.50 C +ATOM 15356 CG2 ILE J 82 26.378 50.952 120.338 1.00 8.50 C +ATOM 15357 CD1 ILE J 82 28.899 49.784 119.046 1.00 25.27 C +ATOM 15358 N LEU J 83 25.505 47.949 122.030 1.00 8.84 N +ATOM 15359 CA LEU J 83 25.115 47.870 123.420 1.00 8.50 C +ATOM 15360 C LEU J 83 26.164 48.203 124.439 1.00 12.58 C +ATOM 15361 O LEU J 83 27.340 47.856 124.284 1.00 14.85 O +ATOM 15362 CB LEU J 83 24.536 46.496 123.723 1.00 10.73 C +ATOM 15363 CG LEU J 83 23.024 46.265 123.740 1.00 8.50 C +ATOM 15364 CD1 LEU J 83 22.368 46.875 122.550 1.00 14.72 C +ATOM 15365 CD2 LEU J 83 22.760 44.779 123.750 1.00 26.34 C +ATOM 15366 N PHE J 84 25.710 48.917 125.470 1.00 17.04 N +ATOM 15367 CA PHE J 84 26.517 49.351 126.607 1.00 12.72 C +ATOM 15368 C PHE J 84 25.662 48.995 127.758 1.00 8.50 C +ATOM 15369 O PHE J 84 24.626 49.611 127.930 1.00 8.50 O +ATOM 15370 CB PHE J 84 26.659 50.864 126.655 1.00 8.50 C +ATOM 15371 CG PHE J 84 27.474 51.421 125.569 1.00 8.50 C +ATOM 15372 CD1 PHE J 84 28.838 51.359 125.628 1.00 8.50 C +ATOM 15373 CD2 PHE J 84 26.873 52.016 124.495 1.00 8.50 C +ATOM 15374 CE1 PHE J 84 29.590 51.883 124.634 1.00 8.50 C +ATOM 15375 CE2 PHE J 84 27.609 52.538 123.504 1.00 8.50 C +ATOM 15376 CZ PHE J 84 28.978 52.477 123.562 1.00 8.50 C +ATOM 15377 N GLU J 85 26.047 47.982 128.512 1.00 8.50 N +ATOM 15378 CA GLU J 85 25.257 47.600 129.663 1.00 20.62 C +ATOM 15379 C GLU J 85 25.963 48.094 130.902 1.00 17.44 C +ATOM 15380 O GLU J 85 27.182 48.073 130.970 1.00 8.50 O +ATOM 15381 CB GLU J 85 25.054 46.079 129.728 1.00 37.91 C +ATOM 15382 CG GLU J 85 26.302 45.253 130.023 1.00 50.77 C +ATOM 15383 CD GLU J 85 26.761 44.405 128.845 1.00 62.19 C +ATOM 15384 OE1 GLU J 85 25.906 43.960 128.046 1.00 60.09 O +ATOM 15385 OE2 GLU J 85 27.985 44.168 128.734 1.00 71.90 O +ATOM 15386 N VAL J 86 25.203 48.624 131.843 1.00 25.86 N +ATOM 15387 CA VAL J 86 25.794 49.091 133.088 1.00 47.75 C +ATOM 15388 C VAL J 86 25.372 48.136 134.220 1.00 57.75 C +ATOM 15389 O VAL J 86 24.172 47.894 134.439 1.00 60.78 O +ATOM 15390 CB VAL J 86 25.439 50.559 133.392 1.00 52.18 C +ATOM 15391 CG1 VAL J 86 26.143 51.481 132.376 1.00 34.44 C +ATOM 15392 CG2 VAL J 86 23.906 50.750 133.404 1.00 58.93 C +ATOM 15393 N PRO J 87 26.367 47.560 134.924 1.00 57.57 N +ATOM 15394 CA PRO J 87 26.224 46.613 136.025 1.00 64.03 C +ATOM 15395 C PRO J 87 25.335 47.013 137.208 1.00 78.52 C +ATOM 15396 O PRO J 87 24.159 46.638 137.261 1.00 87.55 O +ATOM 15397 CB PRO J 87 27.674 46.364 136.433 1.00 62.69 C +ATOM 15398 CG PRO J 87 28.348 47.653 136.094 1.00 56.28 C +ATOM 15399 CD PRO J 87 27.787 47.926 134.749 1.00 54.87 C +ATOM 15400 N GLU J 88 25.907 47.728 138.177 1.00 84.57 N +ATOM 15401 CA GLU J 88 25.161 48.136 139.365 1.00 89.31 C +ATOM 15402 C GLU J 88 24.032 49.100 139.048 1.00 86.10 C +ATOM 15403 O GLU J 88 24.262 50.190 138.510 1.00 84.28 O +ATOM 15404 CB GLU J 88 26.091 48.774 140.400 1.00 97.24 C +ATOM 15405 CG GLU J 88 25.375 49.207 141.679 1.00102.16 C +ATOM 15406 CD GLU J 88 26.028 50.411 142.345 1.00108.74 C +ATOM 15407 OE1 GLU J 88 27.179 50.278 142.814 1.00112.56 O +ATOM 15408 OE2 GLU J 88 25.392 51.492 142.403 1.00108.40 O +ATOM 15409 N VAL J 89 22.818 48.700 139.407 1.00 83.75 N +ATOM 15410 CA VAL J 89 21.657 49.540 139.172 1.00 89.07 C +ATOM 15411 C VAL J 89 21.423 50.496 140.356 1.00 88.30 C +ATOM 15412 O VAL J 89 20.987 50.091 141.441 1.00 86.57 O +ATOM 15413 CB VAL J 89 20.384 48.694 138.826 1.00 95.26 C +ATOM 15414 CG1 VAL J 89 19.856 47.938 140.048 1.00 99.37 C +ATOM 15415 CG2 VAL J 89 19.307 49.578 138.202 1.00 92.51 C +ATOM 15416 N THR J 90 21.812 51.754 140.156 1.00 86.05 N +ATOM 15417 CA THR J 90 21.648 52.794 141.165 1.00 75.90 C +ATOM 15418 C THR J 90 20.298 53.465 140.901 1.00 73.30 C +ATOM 15419 O THR J 90 19.983 53.832 139.748 1.00 71.79 O +ATOM 15420 CB THR J 90 22.810 53.831 141.099 1.00 73.09 C +ATOM 15421 OG1 THR J 90 22.773 54.682 142.254 1.00 73.90 O +ATOM 15422 CG2 THR J 90 22.713 54.685 139.835 1.00 73.55 C +ATOM 15423 N VAL J 91 19.466 53.522 141.941 1.00 65.67 N +ATOM 15424 CA VAL J 91 18.146 54.147 141.825 1.00 58.59 C +ATOM 15425 C VAL J 91 18.297 55.619 142.200 1.00 43.60 C +ATOM 15426 O VAL J 91 18.211 56.000 143.368 1.00 39.37 O +ATOM 15427 CB VAL J 91 17.074 53.414 142.686 1.00 65.57 C +ATOM 15428 CG1 VAL J 91 17.480 53.378 144.171 1.00 68.82 C +ATOM 15429 CG2 VAL J 91 15.700 54.054 142.475 1.00 58.35 C +ATOM 15430 N ALA J 92 18.578 56.416 141.175 1.00 33.48 N +ATOM 15431 CA ALA J 92 18.819 57.844 141.291 1.00 25.29 C +ATOM 15432 C ALA J 92 18.865 58.444 139.884 1.00 24.25 C +ATOM 15433 O ALA J 92 18.790 57.714 138.888 1.00 42.00 O +ATOM 15434 CB ALA J 92 20.181 58.063 141.971 1.00 16.81 C +ATOM 15435 N PRO J 93 18.879 59.782 139.780 1.00 8.54 N +ATOM 15436 CA PRO J 93 18.946 60.450 138.491 1.00 8.50 C +ATOM 15437 C PRO J 93 20.274 60.041 137.872 1.00 9.42 C +ATOM 15438 O PRO J 93 21.239 59.762 138.585 1.00 20.42 O +ATOM 15439 CB PRO J 93 18.961 61.906 138.899 1.00 8.50 C +ATOM 15440 CG PRO J 93 18.137 61.916 140.081 1.00 8.50 C +ATOM 15441 CD PRO J 93 18.645 60.766 140.840 1.00 8.50 C +ATOM 15442 N VAL J 94 20.324 59.977 136.554 1.00 9.74 N +ATOM 15443 CA VAL J 94 21.547 59.590 135.861 1.00 8.68 C +ATOM 15444 C VAL J 94 21.816 60.584 134.732 1.00 8.50 C +ATOM 15445 O VAL J 94 20.892 61.194 134.175 1.00 8.50 O +ATOM 15446 CB VAL J 94 21.456 58.111 135.390 1.00 8.50 C +ATOM 15447 CG1 VAL J 94 20.057 57.782 134.928 1.00 23.74 C +ATOM 15448 CG2 VAL J 94 22.428 57.821 134.307 1.00 14.59 C +ATOM 15449 N HIS J 95 23.085 60.848 134.490 1.00 8.50 N +ATOM 15450 CA HIS J 95 23.482 61.795 133.462 1.00 8.50 C +ATOM 15451 C HIS J 95 24.311 61.056 132.424 1.00 13.61 C +ATOM 15452 O HIS J 95 25.297 60.410 132.790 1.00 18.94 O +ATOM 15453 CB HIS J 95 24.321 62.924 134.108 1.00 15.58 C +ATOM 15454 CG HIS J 95 25.013 63.831 133.131 1.00 8.50 C +ATOM 15455 ND1 HIS J 95 24.424 64.962 132.615 1.00 8.50 N +ATOM 15456 CD2 HIS J 95 26.246 63.766 132.581 1.00 8.50 C +ATOM 15457 CE1 HIS J 95 25.259 65.554 131.786 1.00 8.50 C +ATOM 15458 NE2 HIS J 95 26.373 64.844 131.749 1.00 8.50 N +ATOM 15459 N ILE J 96 23.947 61.163 131.145 1.00 8.90 N +ATOM 15460 CA ILE J 96 24.702 60.493 130.106 1.00 8.50 C +ATOM 15461 C ILE J 96 25.117 61.438 129.008 1.00 8.50 C +ATOM 15462 O ILE J 96 24.466 62.437 128.775 1.00 9.81 O +ATOM 15463 CB ILE J 96 23.909 59.342 129.482 1.00 8.50 C +ATOM 15464 CG1 ILE J 96 22.613 59.859 128.881 1.00 8.50 C +ATOM 15465 CG2 ILE J 96 23.632 58.245 130.515 1.00 8.50 C +ATOM 15466 CD1 ILE J 96 21.923 58.864 128.022 1.00 15.56 C +ATOM 15467 N CYS J 97 26.272 61.175 128.422 1.00 8.50 N +ATOM 15468 CA CYS J 97 26.790 61.947 127.298 1.00 9.97 C +ATOM 15469 C CYS J 97 27.236 60.863 126.354 1.00 8.50 C +ATOM 15470 O CYS J 97 27.897 59.940 126.785 1.00 8.50 O +ATOM 15471 CB CYS J 97 28.034 62.792 127.643 1.00 12.63 C +ATOM 15472 SG CYS J 97 27.804 64.473 128.331 1.00 8.50 S +ATOM 15473 N THR J 98 26.875 60.968 125.083 1.00 8.50 N +ATOM 15474 CA THR J 98 27.257 59.980 124.104 1.00 8.50 C +ATOM 15475 C THR J 98 27.692 60.691 122.836 1.00 8.50 C +ATOM 15476 O THR J 98 27.157 61.752 122.526 1.00 16.05 O +ATOM 15477 CB THR J 98 26.103 59.017 123.849 1.00 8.50 C +ATOM 15478 OG1 THR J 98 26.524 58.013 122.921 1.00 34.06 O +ATOM 15479 CG2 THR J 98 24.885 59.729 123.337 1.00 8.50 C +ATOM 15480 N SER J 99 28.701 60.159 122.146 1.00 8.50 N +ATOM 15481 CA SER J 99 29.214 60.786 120.932 1.00 8.50 C +ATOM 15482 C SER J 99 29.596 59.825 119.834 1.00 8.54 C +ATOM 15483 O SER J 99 29.971 58.715 120.106 1.00 20.47 O +ATOM 15484 CB SER J 99 30.401 61.689 121.252 1.00 9.73 C +ATOM 15485 OG SER J 99 31.400 61.050 122.022 1.00 8.50 O +ATOM 15486 N TRP J 100 29.518 60.270 118.589 1.00 10.94 N +ATOM 15487 CA TRP J 100 29.840 59.446 117.429 1.00 10.81 C +ATOM 15488 C TRP J 100 30.620 60.269 116.404 1.00 10.85 C +ATOM 15489 O TRP J 100 30.390 61.468 116.259 1.00 15.77 O +ATOM 15490 CB TRP J 100 28.547 58.893 116.816 1.00 15.00 C +ATOM 15491 CG TRP J 100 28.689 58.298 115.445 1.00 18.06 C +ATOM 15492 CD1 TRP J 100 29.134 57.049 115.131 1.00 18.58 C +ATOM 15493 CD2 TRP J 100 28.393 58.944 114.201 1.00 20.47 C +ATOM 15494 NE1 TRP J 100 29.138 56.879 113.766 1.00 20.18 N +ATOM 15495 CE2 TRP J 100 28.688 58.024 113.169 1.00 18.77 C +ATOM 15496 CE3 TRP J 100 27.905 60.212 113.858 1.00 18.63 C +ATOM 15497 CZ2 TRP J 100 28.511 58.330 111.816 1.00 16.99 C +ATOM 15498 CZ3 TRP J 100 27.726 60.515 112.510 1.00 21.66 C +ATOM 15499 CH2 TRP J 100 28.029 59.574 111.506 1.00 17.94 C +ATOM 15500 N GLU J 101 31.526 59.615 115.687 1.00 10.40 N +ATOM 15501 CA GLU J 101 32.368 60.254 114.684 1.00 13.70 C +ATOM 15502 C GLU J 101 32.354 59.427 113.394 1.00 17.46 C +ATOM 15503 O GLU J 101 32.823 58.304 113.386 1.00 20.29 O +ATOM 15504 CB GLU J 101 33.800 60.355 115.219 1.00 8.50 C +ATOM 15505 CG GLU J 101 34.785 60.952 114.265 1.00 8.50 C +ATOM 15506 CD GLU J 101 36.186 61.001 114.817 1.00 8.59 C +ATOM 15507 OE1 GLU J 101 36.809 59.935 114.902 1.00 21.44 O +ATOM 15508 OE2 GLU J 101 36.688 62.097 115.151 1.00 17.09 O +ATOM 15509 N SER J 102 31.841 59.983 112.300 1.00 18.78 N +ATOM 15510 CA SER J 102 31.796 59.259 111.040 1.00 14.69 C +ATOM 15511 C SER J 102 33.181 58.799 110.601 1.00 12.41 C +ATOM 15512 O SER J 102 33.371 57.666 110.234 1.00 19.73 O +ATOM 15513 CB SER J 102 31.159 60.112 109.940 1.00 11.93 C +ATOM 15514 OG SER J 102 31.359 59.551 108.646 1.00 8.50 O +ATOM 15515 N ALA J 103 34.162 59.669 110.696 1.00 10.46 N +ATOM 15516 CA ALA J 103 35.519 59.342 110.273 1.00 14.63 C +ATOM 15517 C ALA J 103 36.156 58.063 110.800 1.00 12.01 C +ATOM 15518 O ALA J 103 37.042 57.524 110.154 1.00 22.52 O +ATOM 15519 CB ALA J 103 36.452 60.532 110.541 1.00 28.18 C +ATOM 15520 N SER J 104 35.742 57.586 111.970 1.00 10.69 N +ATOM 15521 CA SER J 104 36.333 56.373 112.534 1.00 8.50 C +ATOM 15522 C SER J 104 35.291 55.383 113.023 1.00 8.50 C +ATOM 15523 O SER J 104 35.557 54.198 113.174 1.00 8.50 O +ATOM 15524 CB SER J 104 37.230 56.738 113.699 1.00 8.50 C +ATOM 15525 OG SER J 104 36.443 57.242 114.753 1.00 8.50 O +ATOM 15526 N GLY J 105 34.102 55.889 113.275 1.00 8.50 N +ATOM 15527 CA GLY J 105 33.032 55.058 113.761 1.00 9.54 C +ATOM 15528 C GLY J 105 33.106 54.935 115.266 1.00 14.56 C +ATOM 15529 O GLY J 105 32.275 54.260 115.873 1.00 23.38 O +ATOM 15530 N ILE J 106 34.080 55.588 115.886 1.00 8.50 N +ATOM 15531 CA ILE J 106 34.198 55.481 117.322 1.00 8.50 C +ATOM 15532 C ILE J 106 33.081 56.200 118.072 1.00 11.00 C +ATOM 15533 O ILE J 106 32.874 57.412 117.906 1.00 17.55 O +ATOM 15534 CB ILE J 106 35.546 55.988 117.821 1.00 8.50 C +ATOM 15535 CG1 ILE J 106 36.668 55.126 117.280 1.00 8.50 C +ATOM 15536 CG2 ILE J 106 35.586 55.951 119.334 1.00 8.50 C +ATOM 15537 CD1 ILE J 106 38.003 55.550 117.744 1.00 8.50 C +ATOM 15538 N VAL J 107 32.376 55.445 118.909 1.00 8.50 N +ATOM 15539 CA VAL J 107 31.298 55.973 119.730 1.00 8.75 C +ATOM 15540 C VAL J 107 31.678 55.809 121.203 1.00 8.50 C +ATOM 15541 O VAL J 107 32.191 54.773 121.580 1.00 9.98 O +ATOM 15542 CB VAL J 107 29.934 55.300 119.404 1.00 8.50 C +ATOM 15543 CG1 VAL J 107 30.096 53.855 119.154 1.00 13.31 C +ATOM 15544 CG2 VAL J 107 28.985 55.482 120.529 1.00 8.50 C +ATOM 15545 N GLU J 108 31.541 56.879 121.992 1.00 12.93 N +ATOM 15546 CA GLU J 108 31.864 56.888 123.425 1.00 8.50 C +ATOM 15547 C GLU J 108 30.540 57.000 124.157 1.00 9.76 C +ATOM 15548 O GLU J 108 29.604 57.616 123.655 1.00 8.50 O +ATOM 15549 CB GLU J 108 32.689 58.126 123.808 1.00 8.50 C +ATOM 15550 CG GLU J 108 34.075 58.280 123.195 1.00 8.50 C +ATOM 15551 CD GLU J 108 34.688 59.663 123.437 1.00 19.46 C +ATOM 15552 OE1 GLU J 108 34.033 60.567 124.019 1.00 28.48 O +ATOM 15553 OE2 GLU J 108 35.837 59.868 123.022 1.00 22.20 O +ATOM 15554 N PHE J 109 30.453 56.413 125.342 1.00 9.54 N +ATOM 15555 CA PHE J 109 29.241 56.519 126.140 1.00 8.50 C +ATOM 15556 C PHE J 109 29.757 56.794 127.530 1.00 8.86 C +ATOM 15557 O PHE J 109 30.580 56.040 128.033 1.00 9.81 O +ATOM 15558 CB PHE J 109 28.464 55.228 126.133 1.00 8.50 C +ATOM 15559 CG PHE J 109 27.013 55.398 126.404 1.00 8.50 C +ATOM 15560 CD1 PHE J 109 26.132 55.676 125.377 1.00 8.50 C +ATOM 15561 CD2 PHE J 109 26.512 55.259 127.668 1.00 8.50 C +ATOM 15562 CE1 PHE J 109 24.771 55.815 125.612 1.00 8.50 C +ATOM 15563 CE2 PHE J 109 25.156 55.395 127.900 1.00 8.50 C +ATOM 15564 CZ PHE J 109 24.292 55.674 126.868 1.00 8.50 C +ATOM 15565 N TRP J 110 29.384 57.941 128.088 1.00 11.23 N +ATOM 15566 CA TRP J 110 29.813 58.339 129.421 1.00 8.50 C +ATOM 15567 C TRP J 110 28.610 58.340 130.326 1.00 8.50 C +ATOM 15568 O TRP J 110 27.640 59.058 130.070 1.00 12.96 O +ATOM 15569 CB TRP J 110 30.379 59.750 129.408 1.00 8.50 C +ATOM 15570 CG TRP J 110 31.585 59.938 128.587 1.00 8.50 C +ATOM 15571 CD1 TRP J 110 31.661 59.888 127.244 1.00 8.50 C +ATOM 15572 CD2 TRP J 110 32.891 60.218 129.049 1.00 8.50 C +ATOM 15573 NE1 TRP J 110 32.938 60.113 126.836 1.00 8.50 N +ATOM 15574 CE2 TRP J 110 33.718 60.320 127.926 1.00 8.50 C +ATOM 15575 CE3 TRP J 110 33.449 60.403 130.315 1.00 8.50 C +ATOM 15576 CZ2 TRP J 110 35.070 60.591 128.021 1.00 8.50 C +ATOM 15577 CZ3 TRP J 110 34.797 60.676 130.409 1.00 8.50 C +ATOM 15578 CH2 TRP J 110 35.595 60.767 129.274 1.00 8.50 C +ATOM 15579 N VAL J 111 28.663 57.557 131.392 1.00 8.50 N +ATOM 15580 CA VAL J 111 27.555 57.528 132.332 1.00 8.50 C +ATOM 15581 C VAL J 111 28.054 58.122 133.645 1.00 15.18 C +ATOM 15582 O VAL J 111 29.057 57.652 134.198 1.00 19.74 O +ATOM 15583 CB VAL J 111 27.051 56.127 132.570 1.00 8.50 C +ATOM 15584 CG1 VAL J 111 25.905 56.151 133.524 1.00 8.50 C +ATOM 15585 CG2 VAL J 111 26.628 55.514 131.276 1.00 14.61 C +ATOM 15586 N ASP J 112 27.393 59.194 134.095 1.00 10.91 N +ATOM 15587 CA ASP J 112 27.736 59.902 135.321 1.00 8.50 C +ATOM 15588 C ASP J 112 29.176 60.377 135.389 1.00 8.50 C +ATOM 15589 O ASP J 112 29.825 60.286 136.421 1.00 8.50 O +ATOM 15590 CB ASP J 112 27.401 59.075 136.553 1.00 8.50 C +ATOM 15591 CG ASP J 112 25.940 59.173 136.949 1.00 9.50 C +ATOM 15592 OD1 ASP J 112 25.316 60.225 136.711 1.00 15.46 O +ATOM 15593 OD2 ASP J 112 25.408 58.199 137.528 1.00 12.20 O +ATOM 15594 N GLY J 113 29.665 60.906 134.280 1.00 8.50 N +ATOM 15595 CA GLY J 113 31.013 61.434 134.237 1.00 8.93 C +ATOM 15596 C GLY J 113 32.133 60.439 134.041 1.00 14.47 C +ATOM 15597 O GLY J 113 33.301 60.843 133.868 1.00 16.88 O +ATOM 15598 N LYS J 114 31.781 59.151 134.070 1.00 11.88 N +ATOM 15599 CA LYS J 114 32.725 58.052 133.907 1.00 9.03 C +ATOM 15600 C LYS J 114 32.504 57.388 132.544 1.00 9.31 C +ATOM 15601 O LYS J 114 31.370 57.004 132.219 1.00 8.50 O +ATOM 15602 CB LYS J 114 32.468 57.049 135.033 1.00 11.18 C +ATOM 15603 CG LYS J 114 32.125 57.705 136.389 1.00 23.22 C +ATOM 15604 CD LYS J 114 32.967 57.206 137.573 1.00 24.39 C +ATOM 15605 CE LYS J 114 34.411 57.721 137.511 1.00 29.31 C +ATOM 15606 NZ LYS J 114 35.201 57.422 138.751 1.00 25.35 N +ATOM 15607 N PRO J 115 33.583 57.233 131.743 1.00 8.50 N +ATOM 15608 CA PRO J 115 33.539 56.636 130.414 1.00 8.94 C +ATOM 15609 C PRO J 115 33.473 55.119 130.342 1.00 9.99 C +ATOM 15610 O PRO J 115 34.107 54.416 131.122 1.00 9.38 O +ATOM 15611 CB PRO J 115 34.842 57.126 129.797 1.00 8.50 C +ATOM 15612 CG PRO J 115 35.769 57.027 130.930 1.00 8.50 C +ATOM 15613 CD PRO J 115 34.975 57.574 132.090 1.00 8.50 C +ATOM 15614 N ARG J 116 32.705 54.636 129.377 1.00 8.50 N +ATOM 15615 CA ARG J 116 32.597 53.233 129.102 1.00 8.50 C +ATOM 15616 C ARG J 116 33.625 53.093 127.979 1.00 9.97 C +ATOM 15617 O ARG J 116 34.057 54.102 127.426 1.00 10.38 O +ATOM 15618 CB ARG J 116 31.210 52.924 128.578 1.00 8.50 C +ATOM 15619 CG ARG J 116 30.112 53.304 129.512 1.00 8.50 C +ATOM 15620 CD ARG J 116 30.027 52.379 130.707 1.00 24.96 C +ATOM 15621 NE ARG J 116 29.384 51.113 130.346 1.00 45.64 N +ATOM 15622 CZ ARG J 116 30.038 49.980 130.111 1.00 45.74 C +ATOM 15623 NH1 ARG J 116 31.363 49.953 130.204 1.00 42.70 N +ATOM 15624 NH2 ARG J 116 29.373 48.885 129.755 1.00 43.75 N +ATOM 15625 N VAL J 117 33.997 51.868 127.615 1.00 12.39 N +ATOM 15626 CA VAL J 117 35.000 51.675 126.574 1.00 11.02 C +ATOM 15627 C VAL J 117 34.517 52.215 125.240 1.00 16.97 C +ATOM 15628 O VAL J 117 33.312 52.423 125.065 1.00 20.28 O +ATOM 15629 CB VAL J 117 35.398 50.207 126.400 1.00 8.50 C +ATOM 15630 CG1 VAL J 117 36.796 50.140 125.807 1.00 15.71 C +ATOM 15631 CG2 VAL J 117 35.366 49.475 127.705 1.00 8.50 C +ATOM 15632 N ARG J 118 35.459 52.479 124.324 1.00 17.24 N +ATOM 15633 CA ARG J 118 35.125 52.993 123.000 1.00 11.40 C +ATOM 15634 C ARG J 118 34.748 51.843 122.060 1.00 10.62 C +ATOM 15635 O ARG J 118 35.420 50.812 122.032 1.00 13.72 O +ATOM 15636 CB ARG J 118 36.297 53.772 122.416 1.00 8.50 C +ATOM 15637 CG ARG J 118 36.752 54.930 123.239 1.00 8.50 C +ATOM 15638 CD ARG J 118 37.647 55.787 122.403 1.00 13.21 C +ATOM 15639 NE ARG J 118 38.736 56.362 123.165 1.00 8.50 N +ATOM 15640 CZ ARG J 118 38.816 57.636 123.479 1.00 8.50 C +ATOM 15641 NH1 ARG J 118 37.874 58.475 123.105 1.00 8.50 N +ATOM 15642 NH2 ARG J 118 39.852 58.064 124.145 1.00 8.50 N +ATOM 15643 N LYS J 119 33.684 52.034 121.289 1.00 8.50 N +ATOM 15644 CA LYS J 119 33.226 51.039 120.354 1.00 8.50 C +ATOM 15645 C LYS J 119 33.122 51.613 118.944 1.00 9.24 C +ATOM 15646 O LYS J 119 33.185 52.818 118.763 1.00 12.45 O +ATOM 15647 CB LYS J 119 31.898 50.489 120.831 1.00 8.50 C +ATOM 15648 CG LYS J 119 32.045 49.726 122.131 1.00 11.07 C +ATOM 15649 CD LYS J 119 30.772 48.998 122.537 1.00 9.64 C +ATOM 15650 CE LYS J 119 31.042 48.063 123.704 1.00 13.36 C +ATOM 15651 NZ LYS J 119 29.834 47.341 124.179 1.00 18.19 N +ATOM 15652 N SER J 120 33.020 50.750 117.939 1.00 16.31 N +ATOM 15653 CA SER J 120 32.922 51.188 116.544 1.00 11.34 C +ATOM 15654 C SER J 120 31.496 51.000 116.060 1.00 8.50 C +ATOM 15655 O SER J 120 30.862 49.995 116.361 1.00 11.78 O +ATOM 15656 CB SER J 120 33.875 50.380 115.663 1.00 8.50 C +ATOM 15657 OG SER J 120 34.186 51.069 114.467 1.00 12.83 O +ATOM 15658 N LEU J 121 30.990 51.969 115.316 1.00 8.50 N +ATOM 15659 CA LEU J 121 29.635 51.893 114.805 1.00 10.46 C +ATOM 15660 C LEU J 121 29.387 52.904 113.675 1.00 19.82 C +ATOM 15661 O LEU J 121 29.709 54.085 113.812 1.00 22.67 O +ATOM 15662 CB LEU J 121 28.638 52.088 115.946 1.00 8.50 C +ATOM 15663 CG LEU J 121 27.181 52.352 115.601 1.00 8.50 C +ATOM 15664 CD1 LEU J 121 26.593 51.244 114.810 1.00 8.50 C +ATOM 15665 CD2 LEU J 121 26.422 52.515 116.868 1.00 10.55 C +ATOM 15666 N LYS J 122 28.876 52.406 112.545 1.00 20.11 N +ATOM 15667 CA LYS J 122 28.547 53.208 111.365 1.00 13.33 C +ATOM 15668 C LYS J 122 29.630 54.127 110.805 1.00 12.70 C +ATOM 15669 O LYS J 122 29.361 55.278 110.501 1.00 12.94 O +ATOM 15670 CB LYS J 122 27.261 53.998 111.607 1.00 8.50 C +ATOM 15671 CG LYS J 122 26.002 53.199 111.393 1.00 8.50 C +ATOM 15672 CD LYS J 122 25.779 52.892 109.931 1.00 15.38 C +ATOM 15673 CE LYS J 122 24.497 52.118 109.709 1.00 23.39 C +ATOM 15674 NZ LYS J 122 24.226 51.864 108.266 1.00 46.69 N +ATOM 15675 N LYS J 123 30.834 53.607 110.622 1.00 9.49 N +ATOM 15676 CA LYS J 123 31.911 54.420 110.092 1.00 10.51 C +ATOM 15677 C LYS J 123 31.555 54.883 108.697 1.00 14.79 C +ATOM 15678 O LYS J 123 30.924 54.156 107.952 1.00 26.74 O +ATOM 15679 CB LYS J 123 33.217 53.639 110.043 1.00 8.50 C +ATOM 15680 CG LYS J 123 34.330 54.455 109.462 1.00 13.07 C +ATOM 15681 CD LYS J 123 35.409 53.634 108.804 1.00 15.47 C +ATOM 15682 CE LYS J 123 36.364 53.058 109.796 1.00 20.08 C +ATOM 15683 NZ LYS J 123 37.589 52.556 109.103 1.00 25.96 N +ATOM 15684 N GLY J 124 31.941 56.102 108.350 1.00 18.18 N +ATOM 15685 CA GLY J 124 31.644 56.628 107.035 1.00 19.28 C +ATOM 15686 C GLY J 124 30.212 57.090 106.827 1.00 17.04 C +ATOM 15687 O GLY J 124 29.928 57.784 105.859 1.00 28.11 O +ATOM 15688 N TYR J 125 29.302 56.706 107.709 1.00 10.80 N +ATOM 15689 CA TYR J 125 27.911 57.116 107.575 1.00 15.95 C +ATOM 15690 C TYR J 125 27.825 58.634 107.742 1.00 19.61 C +ATOM 15691 O TYR J 125 28.808 59.284 108.074 1.00 19.93 O +ATOM 15692 CB TYR J 125 27.040 56.414 108.638 1.00 16.58 C +ATOM 15693 CG TYR J 125 25.536 56.626 108.492 1.00 8.85 C +ATOM 15694 CD1 TYR J 125 24.793 55.876 107.614 1.00 19.84 C +ATOM 15695 CD2 TYR J 125 24.872 57.565 109.245 1.00 17.49 C +ATOM 15696 CE1 TYR J 125 23.427 56.054 107.494 1.00 25.82 C +ATOM 15697 CE2 TYR J 125 23.502 57.751 109.124 1.00 18.73 C +ATOM 15698 CZ TYR J 125 22.789 56.995 108.255 1.00 17.78 C +ATOM 15699 OH TYR J 125 21.429 57.163 108.164 1.00 16.50 O +ATOM 15700 N THR J 126 26.645 59.192 107.497 1.00 25.17 N +ATOM 15701 CA THR J 126 26.411 60.626 107.645 1.00 23.30 C +ATOM 15702 C THR J 126 24.940 60.844 108.047 1.00 21.45 C +ATOM 15703 O THR J 126 24.023 60.398 107.357 1.00 22.55 O +ATOM 15704 CB THR J 126 26.839 61.398 106.361 1.00 15.70 C +ATOM 15705 OG1 THR J 126 26.172 62.656 106.298 1.00 25.71 O +ATOM 15706 CG2 THR J 126 26.534 60.611 105.116 1.00 31.62 C +ATOM 15707 N VAL J 127 24.739 61.434 109.225 1.00 20.39 N +ATOM 15708 CA VAL J 127 23.398 61.662 109.766 1.00 17.22 C +ATOM 15709 C VAL J 127 22.630 62.759 109.031 1.00 16.39 C +ATOM 15710 O VAL J 127 23.179 63.793 108.680 1.00 12.15 O +ATOM 15711 CB VAL J 127 23.456 61.946 111.289 1.00 9.39 C +ATOM 15712 CG1 VAL J 127 22.095 62.233 111.845 1.00 8.50 C +ATOM 15713 CG2 VAL J 127 24.043 60.768 112.008 1.00 16.57 C +ATOM 15714 N GLY J 128 21.349 62.513 108.801 1.00 17.52 N +ATOM 15715 CA GLY J 128 20.499 63.468 108.117 1.00 22.79 C +ATOM 15716 C GLY J 128 20.298 64.771 108.868 1.00 27.60 C +ATOM 15717 O GLY J 128 20.161 64.776 110.087 1.00 30.21 O +ATOM 15718 N ALA J 129 20.223 65.869 108.116 1.00 31.12 N +ATOM 15719 CA ALA J 129 20.063 67.212 108.661 1.00 32.37 C +ATOM 15720 C ALA J 129 18.647 67.642 109.068 1.00 42.07 C +ATOM 15721 O ALA J 129 18.470 68.381 110.053 1.00 47.36 O +ATOM 15722 CB ALA J 129 20.636 68.197 107.717 1.00 18.07 C +ATOM 15723 N GLU J 130 17.642 67.252 108.293 1.00 43.36 N +ATOM 15724 CA GLU J 130 16.272 67.616 108.652 1.00 48.69 C +ATOM 15725 C GLU J 130 15.682 66.478 109.447 1.00 43.92 C +ATOM 15726 O GLU J 130 15.447 65.401 108.903 1.00 47.59 O +ATOM 15727 CB GLU J 130 15.429 67.906 107.419 1.00 64.81 C +ATOM 15728 CG GLU J 130 15.429 66.821 106.356 1.00 93.14 C +ATOM 15729 CD GLU J 130 14.573 67.194 105.146 1.00105.51 C +ATOM 15730 OE1 GLU J 130 15.109 67.834 104.215 1.00111.61 O +ATOM 15731 OE2 GLU J 130 13.364 66.861 105.127 1.00109.40 O +ATOM 15732 N ALA J 131 15.449 66.711 110.734 1.00 37.25 N +ATOM 15733 CA ALA J 131 14.942 65.651 111.593 1.00 29.91 C +ATOM 15734 C ALA J 131 13.920 66.053 112.629 1.00 21.45 C +ATOM 15735 O ALA J 131 13.789 67.219 112.970 1.00 27.64 O +ATOM 15736 CB ALA J 131 16.102 64.962 112.282 1.00 33.21 C +ATOM 15737 N SER J 132 13.188 65.063 113.110 1.00 13.97 N +ATOM 15738 CA SER J 132 12.197 65.263 114.136 1.00 17.44 C +ATOM 15739 C SER J 132 12.866 64.675 115.368 1.00 21.48 C +ATOM 15740 O SER J 132 13.234 63.493 115.374 1.00 25.98 O +ATOM 15741 CB SER J 132 10.914 64.509 113.789 1.00 13.42 C +ATOM 15742 OG SER J 132 9.919 64.664 114.789 1.00 19.68 O +ATOM 15743 N ILE J 133 13.106 65.523 116.361 1.00 14.08 N +ATOM 15744 CA ILE J 133 13.735 65.128 117.607 1.00 10.61 C +ATOM 15745 C ILE J 133 12.672 65.074 118.695 1.00 11.47 C +ATOM 15746 O ILE J 133 12.074 66.080 119.008 1.00 23.07 O +ATOM 15747 CB ILE J 133 14.815 66.137 117.985 1.00 8.50 C +ATOM 15748 CG1 ILE J 133 15.787 66.284 116.817 1.00 9.66 C +ATOM 15749 CG2 ILE J 133 15.554 65.697 119.246 1.00 8.50 C +ATOM 15750 CD1 ILE J 133 16.881 67.292 117.051 1.00 9.96 C +ATOM 15751 N ILE J 134 12.419 63.906 119.268 1.00 11.13 N +ATOM 15752 CA ILE J 134 11.396 63.793 120.294 1.00 10.97 C +ATOM 15753 C ILE J 134 11.881 63.228 121.609 1.00 12.28 C +ATOM 15754 O ILE J 134 12.733 62.346 121.662 1.00 19.41 O +ATOM 15755 CB ILE J 134 10.176 63.019 119.769 1.00 12.86 C +ATOM 15756 CG1 ILE J 134 9.381 63.946 118.851 1.00 23.59 C +ATOM 15757 CG2 ILE J 134 9.318 62.473 120.905 1.00 8.50 C +ATOM 15758 CD1 ILE J 134 8.152 63.313 118.217 1.00 43.42 C +ATOM 15759 N LEU J 135 11.337 63.777 122.677 1.00 9.57 N +ATOM 15760 CA LEU J 135 11.679 63.368 124.016 1.00 9.31 C +ATOM 15761 C LEU J 135 10.487 62.631 124.611 1.00 11.75 C +ATOM 15762 O LEU J 135 9.337 63.059 124.443 1.00 15.33 O +ATOM 15763 CB LEU J 135 11.997 64.629 124.842 1.00 8.89 C +ATOM 15764 CG LEU J 135 13.434 65.072 125.092 1.00 8.50 C +ATOM 15765 CD1 LEU J 135 14.287 64.820 123.928 1.00 8.50 C +ATOM 15766 CD2 LEU J 135 13.458 66.514 125.437 1.00 8.50 C +ATOM 15767 N GLY J 136 10.753 61.503 125.259 1.00 12.62 N +ATOM 15768 CA GLY J 136 9.688 60.763 125.918 1.00 25.97 C +ATOM 15769 C GLY J 136 9.006 59.666 125.134 1.00 28.66 C +ATOM 15770 O GLY J 136 8.180 58.926 125.708 1.00 28.05 O +ATOM 15771 N GLN J 137 9.524 59.415 123.926 1.00 20.04 N +ATOM 15772 CA GLN J 137 8.948 58.424 123.034 1.00 12.01 C +ATOM 15773 C GLN J 137 9.777 58.162 121.786 1.00 14.09 C +ATOM 15774 O GLN J 137 10.451 59.045 121.272 1.00 8.50 O +ATOM 15775 CB GLN J 137 7.551 58.892 122.621 1.00 8.66 C +ATOM 15776 CG GLN J 137 6.788 57.908 121.801 1.00 10.85 C +ATOM 15777 CD GLN J 137 5.377 58.367 121.510 1.00 30.31 C +ATOM 15778 OE1 GLN J 137 5.119 59.016 120.489 1.00 32.45 O +ATOM 15779 NE2 GLN J 137 4.444 58.020 122.399 1.00 40.28 N +ATOM 15780 N GLU J 138 9.720 56.916 121.322 1.00 34.07 N +ATOM 15781 CA GLU J 138 10.423 56.452 120.116 1.00 36.55 C +ATOM 15782 C GLU J 138 9.735 57.099 118.927 1.00 35.88 C +ATOM 15783 O GLU J 138 8.578 57.510 119.019 1.00 37.29 O +ATOM 15784 CB GLU J 138 10.341 54.916 120.010 1.00 40.24 C +ATOM 15785 CG GLU J 138 10.970 54.341 118.747 1.00 50.53 C +ATOM 15786 CD GLU J 138 11.115 52.827 118.772 1.00 61.15 C +ATOM 15787 OE1 GLU J 138 10.395 52.163 119.560 1.00 64.21 O +ATOM 15788 OE2 GLU J 138 11.955 52.305 117.995 1.00 47.73 O +ATOM 15789 N GLN J 139 10.400 57.141 117.787 1.00 35.35 N +ATOM 15790 CA GLN J 139 9.778 57.796 116.657 1.00 33.05 C +ATOM 15791 C GLN J 139 9.855 57.023 115.375 1.00 32.67 C +ATOM 15792 O GLN J 139 10.920 56.899 114.791 1.00 34.64 O +ATOM 15793 CB GLN J 139 10.439 59.126 116.473 1.00 36.97 C +ATOM 15794 CG GLN J 139 9.548 60.144 115.932 1.00 30.06 C +ATOM 15795 CD GLN J 139 10.346 61.218 115.342 1.00 15.33 C +ATOM 15796 OE1 GLN J 139 10.103 61.590 114.211 1.00 37.58 O +ATOM 15797 NE2 GLN J 139 11.360 61.680 116.055 1.00 8.50 N +ATOM 15798 N ASP J 140 8.707 56.557 114.912 1.00 39.62 N +ATOM 15799 CA ASP J 140 8.635 55.766 113.693 1.00 62.24 C +ATOM 15800 C ASP J 140 7.586 56.403 112.787 1.00 70.54 C +ATOM 15801 O ASP J 140 6.429 55.967 112.689 1.00 60.76 O +ATOM 15802 CB ASP J 140 8.297 54.317 114.056 1.00 81.22 C +ATOM 15803 CG ASP J 140 9.073 53.823 115.299 1.00 91.24 C +ATOM 15804 OD1 ASP J 140 10.273 53.465 115.182 1.00 85.14 O +ATOM 15805 OD2 ASP J 140 8.480 53.819 116.406 1.00 97.59 O +ATOM 15806 N SER J 141 8.049 57.496 112.191 1.00 87.08 N +ATOM 15807 CA SER J 141 7.336 58.404 111.294 1.00 99.07 C +ATOM 15808 C SER J 141 6.057 58.046 110.539 1.00100.20 C +ATOM 15809 O SER J 141 4.951 58.372 110.994 1.00103.10 O +ATOM 15810 CB SER J 141 8.357 59.049 110.330 1.00104.24 C +ATOM 15811 OG SER J 141 9.214 60.010 110.990 1.00109.21 O +ATOM 15812 N PHE J 142 6.205 57.417 109.378 1.00 99.93 N +ATOM 15813 CA PHE J 142 5.050 57.078 108.549 1.00102.62 C +ATOM 15814 C PHE J 142 4.022 56.068 109.070 1.00102.74 C +ATOM 15815 O PHE J 142 3.288 55.467 108.269 1.00 96.44 O +ATOM 15816 CB PHE J 142 5.487 56.726 107.120 1.00102.26 C +ATOM 15817 CG PHE J 142 6.691 55.823 107.044 1.00105.73 C +ATOM 15818 CD1 PHE J 142 6.543 54.437 107.102 1.00112.07 C +ATOM 15819 CD2 PHE J 142 7.963 56.350 106.846 1.00102.33 C +ATOM 15820 CE1 PHE J 142 7.645 53.582 106.957 1.00109.96 C +ATOM 15821 CE2 PHE J 142 9.070 55.511 106.700 1.00108.21 C +ATOM 15822 CZ PHE J 142 8.911 54.120 106.755 1.00110.28 C +ATOM 15823 N GLY J 143 3.935 55.940 110.402 1.00105.23 N +ATOM 15824 CA GLY J 143 2.993 55.028 111.031 1.00102.58 C +ATOM 15825 C GLY J 143 3.211 53.624 110.520 1.00 99.70 C +ATOM 15826 O GLY J 143 3.916 53.423 109.549 1.00102.98 O +ATOM 15827 N GLY J 144 2.673 52.624 111.194 1.00 98.46 N +ATOM 15828 CA GLY J 144 2.877 51.282 110.690 1.00 94.96 C +ATOM 15829 C GLY J 144 3.199 50.273 111.770 1.00 90.29 C +ATOM 15830 O GLY J 144 3.348 49.091 111.484 1.00 98.68 O +ATOM 15831 N ASN J 145 3.399 50.732 112.998 1.00 79.90 N +ATOM 15832 CA ASN J 145 3.659 49.802 114.093 1.00 61.70 C +ATOM 15833 C ASN J 145 2.271 49.291 114.457 1.00 43.50 C +ATOM 15834 O ASN J 145 1.270 50.012 114.277 1.00 34.07 O +ATOM 15835 CB ASN J 145 4.338 50.506 115.288 1.00 79.08 C +ATOM 15836 CG ASN J 145 5.688 51.170 114.917 1.00 79.12 C +ATOM 15837 OD1 ASN J 145 6.006 52.250 115.412 1.00 87.37 O +ATOM 15838 ND2 ASN J 145 6.480 50.515 114.068 1.00 71.53 N +ATOM 15839 N PHE J 146 2.190 48.050 114.914 1.00 26.91 N +ATOM 15840 CA PHE J 146 0.888 47.506 115.238 1.00 35.72 C +ATOM 15841 C PHE J 146 0.305 48.208 116.474 1.00 42.71 C +ATOM 15842 O PHE J 146 -0.891 48.559 116.514 1.00 41.86 O +ATOM 15843 CB PHE J 146 0.969 45.971 115.405 1.00 35.80 C +ATOM 15844 CG PHE J 146 -0.302 45.334 115.939 1.00 35.82 C +ATOM 15845 CD1 PHE J 146 -1.554 45.913 115.712 1.00 41.32 C +ATOM 15846 CD2 PHE J 146 -0.233 44.213 116.749 1.00 27.27 C +ATOM 15847 CE1 PHE J 146 -2.710 45.393 116.292 1.00 41.20 C +ATOM 15848 CE2 PHE J 146 -1.379 43.682 117.332 1.00 37.38 C +ATOM 15849 CZ PHE J 146 -2.623 44.275 117.104 1.00 40.86 C +ATOM 15850 N GLU J 147 1.143 48.416 117.480 1.00 41.31 N +ATOM 15851 CA GLU J 147 0.691 49.059 118.694 1.00 46.26 C +ATOM 15852 C GLU J 147 1.548 50.278 119.006 1.00 52.43 C +ATOM 15853 O GLU J 147 2.619 50.458 118.413 1.00 38.88 O +ATOM 15854 CB GLU J 147 0.716 48.047 119.853 1.00 44.52 C +ATOM 15855 CG GLU J 147 -0.552 47.176 119.998 1.00 39.97 C +ATOM 15856 CD GLU J 147 -0.302 45.953 120.874 1.00 49.48 C +ATOM 15857 OE1 GLU J 147 0.648 45.178 120.569 1.00 40.43 O +ATOM 15858 OE2 GLU J 147 -1.043 45.767 121.867 1.00 52.91 O +ATOM 15859 N GLY J 148 1.051 51.117 119.916 1.00 56.63 N +ATOM 15860 CA GLY J 148 1.776 52.306 120.334 1.00 57.66 C +ATOM 15861 C GLY J 148 3.256 52.170 120.668 1.00 60.78 C +ATOM 15862 O GLY J 148 3.802 51.078 120.770 1.00 67.99 O +ATOM 15863 N SER J 149 3.876 53.310 120.941 1.00 61.99 N +ATOM 15864 CA SER J 149 5.293 53.380 121.248 1.00 59.56 C +ATOM 15865 C SER J 149 5.564 53.295 122.748 1.00 56.11 C +ATOM 15866 O SER J 149 6.592 52.766 123.161 1.00 64.36 O +ATOM 15867 CB SER J 149 5.844 54.672 120.661 1.00 67.57 C +ATOM 15868 OG SER J 149 5.039 55.091 119.560 1.00 71.38 O +ATOM 15869 N GLN J 150 4.625 53.795 123.553 1.00 49.43 N +ATOM 15870 CA GLN J 150 4.734 53.779 125.015 1.00 48.15 C +ATOM 15871 C GLN J 150 5.905 54.679 125.488 1.00 46.57 C +ATOM 15872 O GLN J 150 7.098 54.359 125.301 1.00 48.94 O +ATOM 15873 CB GLN J 150 4.821 52.318 125.546 1.00 44.63 C +ATOM 15874 CG GLN J 150 4.741 52.134 127.088 1.00 60.67 C +ATOM 15875 CD GLN J 150 3.347 52.373 127.675 1.00 71.99 C +ATOM 15876 OE1 GLN J 150 2.485 51.490 127.632 1.00 71.90 O +ATOM 15877 NE2 GLN J 150 3.130 53.565 128.244 1.00 79.36 N +ATOM 15878 N SER J 151 5.529 55.797 126.110 1.00 33.57 N +ATOM 15879 CA SER J 151 6.459 56.816 126.600 1.00 23.93 C +ATOM 15880 C SER J 151 7.222 56.606 127.918 1.00 22.82 C +ATOM 15881 O SER J 151 6.803 55.819 128.765 1.00 29.63 O +ATOM 15882 CB SER J 151 5.692 58.118 126.717 1.00 8.50 C +ATOM 15883 OG SER J 151 5.054 58.410 125.496 1.00 22.40 O +ATOM 15884 N LEU J 152 8.343 57.321 128.055 1.00 20.16 N +ATOM 15885 CA LEU J 152 9.202 57.386 129.253 1.00 16.51 C +ATOM 15886 C LEU J 152 8.321 57.931 130.360 1.00 10.28 C +ATOM 15887 O LEU J 152 7.482 58.789 130.110 1.00 9.03 O +ATOM 15888 CB LEU J 152 10.340 58.396 129.045 1.00 16.42 C +ATOM 15889 CG LEU J 152 11.078 58.916 130.275 1.00 8.50 C +ATOM 15890 CD1 LEU J 152 12.101 57.918 130.740 1.00 8.50 C +ATOM 15891 CD2 LEU J 152 11.764 60.204 129.907 1.00 8.50 C +ATOM 15892 N VAL J 153 8.493 57.406 131.564 1.00 8.50 N +ATOM 15893 CA VAL J 153 7.712 57.852 132.703 1.00 8.50 C +ATOM 15894 C VAL J 153 8.711 58.287 133.743 1.00 13.52 C +ATOM 15895 O VAL J 153 9.410 57.451 134.312 1.00 9.42 O +ATOM 15896 CB VAL J 153 6.841 56.739 133.286 1.00 8.50 C +ATOM 15897 CG1 VAL J 153 5.883 57.308 134.292 1.00 19.93 C +ATOM 15898 CG2 VAL J 153 6.055 56.051 132.197 1.00 11.99 C +ATOM 15899 N GLY J 154 8.799 59.605 133.943 1.00 17.09 N +ATOM 15900 CA GLY J 154 9.738 60.196 134.883 1.00 11.50 C +ATOM 15901 C GLY J 154 10.139 61.587 134.405 1.00 13.53 C +ATOM 15902 O GLY J 154 9.392 62.245 133.667 1.00 14.16 O +ATOM 15903 N ASP J 155 11.327 62.028 134.792 1.00 9.73 N +ATOM 15904 CA ASP J 155 11.804 63.347 134.433 1.00 8.50 C +ATOM 15905 C ASP J 155 12.941 63.255 133.463 1.00 8.50 C +ATOM 15906 O ASP J 155 13.725 62.316 133.507 1.00 8.50 O +ATOM 15907 CB ASP J 155 12.335 64.083 135.677 1.00 13.29 C +ATOM 15908 CG ASP J 155 11.251 64.486 136.641 1.00 8.94 C +ATOM 15909 OD1 ASP J 155 10.518 63.598 137.122 1.00 10.89 O +ATOM 15910 OD2 ASP J 155 11.166 65.697 136.934 1.00 10.87 O +ATOM 15911 N ILE J 156 13.069 64.268 132.622 1.00 8.59 N +ATOM 15912 CA ILE J 156 14.167 64.330 131.677 1.00 10.30 C +ATOM 15913 C ILE J 156 14.464 65.798 131.515 1.00 9.55 C +ATOM 15914 O ILE J 156 13.546 66.608 131.469 1.00 10.78 O +ATOM 15915 CB ILE J 156 13.823 63.694 130.326 1.00 8.50 C +ATOM 15916 CG1 ILE J 156 15.037 63.743 129.417 1.00 8.50 C +ATOM 15917 CG2 ILE J 156 12.675 64.406 129.677 1.00 8.50 C +ATOM 15918 CD1 ILE J 156 14.825 63.045 128.121 1.00 8.50 C +ATOM 15919 N GLY J 157 15.746 66.137 131.484 1.00 9.56 N +ATOM 15920 CA GLY J 157 16.136 67.523 131.353 1.00 8.50 C +ATOM 15921 C GLY J 157 17.580 67.673 130.964 1.00 8.50 C +ATOM 15922 O GLY J 157 18.267 66.697 130.712 1.00 8.50 O +ATOM 15923 N ASN J 158 18.038 68.909 130.946 1.00 8.50 N +ATOM 15924 CA ASN J 158 19.394 69.240 130.573 1.00 8.50 C +ATOM 15925 C ASN J 158 19.892 68.604 129.287 1.00 8.50 C +ATOM 15926 O ASN J 158 21.031 68.168 129.225 1.00 10.86 O +ATOM 15927 CB ASN J 158 20.359 68.949 131.705 1.00 8.50 C +ATOM 15928 CG ASN J 158 20.448 70.071 132.684 1.00 8.50 C +ATOM 15929 OD1 ASN J 158 20.257 69.877 133.879 1.00 15.66 O +ATOM 15930 ND2 ASN J 158 20.763 71.257 132.196 1.00 23.63 N +ATOM 15931 N VAL J 159 19.054 68.567 128.254 1.00 8.50 N +ATOM 15932 CA VAL J 159 19.468 67.996 126.981 1.00 8.50 C +ATOM 15933 C VAL J 159 20.181 69.063 126.164 1.00 8.50 C +ATOM 15934 O VAL J 159 19.732 70.204 126.083 1.00 9.84 O +ATOM 15935 CB VAL J 159 18.295 67.320 126.198 1.00 8.50 C +ATOM 15936 CG1 VAL J 159 16.964 67.577 126.841 1.00 8.50 C +ATOM 15937 CG2 VAL J 159 18.285 67.737 124.766 1.00 8.50 C +ATOM 15938 N ASN J 160 21.347 68.712 125.648 1.00 8.50 N +ATOM 15939 CA ASN J 160 22.166 69.617 124.845 1.00 10.31 C +ATOM 15940 C ASN J 160 22.797 68.760 123.765 1.00 11.11 C +ATOM 15941 O ASN J 160 22.956 67.561 123.967 1.00 14.67 O +ATOM 15942 CB ASN J 160 23.270 70.269 125.687 1.00 8.50 C +ATOM 15943 CG ASN J 160 22.723 71.164 126.765 1.00 8.50 C +ATOM 15944 OD1 ASN J 160 22.604 70.757 127.916 1.00 29.08 O +ATOM 15945 ND2 ASN J 160 22.405 72.400 126.413 1.00 21.01 N +ATOM 15946 N MET J 161 23.178 69.368 122.641 1.00 8.50 N +ATOM 15947 CA MET J 161 23.764 68.632 121.530 1.00 8.69 C +ATOM 15948 C MET J 161 24.742 69.482 120.756 1.00 8.50 C +ATOM 15949 O MET J 161 24.471 70.622 120.473 1.00 11.32 O +ATOM 15950 CB MET J 161 22.656 68.130 120.601 1.00 11.87 C +ATOM 15951 CG MET J 161 23.105 67.286 119.444 1.00 8.50 C +ATOM 15952 SD MET J 161 21.670 66.607 118.616 1.00 8.50 S +ATOM 15953 CE MET J 161 22.499 65.451 117.476 1.00 13.11 C +ATOM 15954 N TRP J 162 25.888 68.911 120.436 1.00 10.06 N +ATOM 15955 CA TRP J 162 26.933 69.584 119.693 1.00 8.50 C +ATOM 15956 C TRP J 162 27.092 68.829 118.381 1.00 8.65 C +ATOM 15957 O TRP J 162 26.735 67.667 118.296 1.00 14.05 O +ATOM 15958 CB TRP J 162 28.261 69.524 120.455 1.00 8.50 C +ATOM 15959 CG TRP J 162 28.305 70.234 121.778 1.00 8.50 C +ATOM 15960 CD1 TRP J 162 28.949 71.393 122.049 1.00 15.96 C +ATOM 15961 CD2 TRP J 162 27.747 69.798 123.021 1.00 9.08 C +ATOM 15962 NE1 TRP J 162 28.836 71.713 123.375 1.00 8.50 N +ATOM 15963 CE2 TRP J 162 28.099 70.749 123.995 1.00 8.50 C +ATOM 15964 CE3 TRP J 162 26.985 68.691 123.409 1.00 18.86 C +ATOM 15965 CZ2 TRP J 162 27.714 70.633 125.330 1.00 8.50 C +ATOM 15966 CZ3 TRP J 162 26.602 68.572 124.741 1.00 14.43 C +ATOM 15967 CH2 TRP J 162 26.969 69.543 125.685 1.00 10.01 C +ATOM 15968 N ASP J 163 27.618 69.489 117.359 1.00 9.95 N +ATOM 15969 CA ASP J 163 27.824 68.857 116.068 1.00 8.50 C +ATOM 15970 C ASP J 163 29.227 68.296 115.922 1.00 10.41 C +ATOM 15971 O ASP J 163 29.648 67.948 114.819 1.00 13.40 O +ATOM 15972 CB ASP J 163 27.467 69.800 114.906 1.00 8.50 C +ATOM 15973 CG ASP J 163 28.376 71.021 114.799 1.00 14.22 C +ATOM 15974 OD1 ASP J 163 29.539 70.985 115.233 1.00 27.06 O +ATOM 15975 OD2 ASP J 163 27.926 72.031 114.227 1.00 19.88 O +ATOM 15976 N PHE J 164 29.962 68.265 117.033 1.00 8.50 N +ATOM 15977 CA PHE J 164 31.323 67.739 117.070 1.00 8.50 C +ATOM 15978 C PHE J 164 31.492 66.876 118.298 1.00 9.04 C +ATOM 15979 O PHE J 164 30.598 66.815 119.131 1.00 17.77 O +ATOM 15980 CB PHE J 164 32.367 68.848 117.037 1.00 8.50 C +ATOM 15981 CG PHE J 164 32.306 69.809 118.201 1.00 11.94 C +ATOM 15982 CD1 PHE J 164 31.443 70.898 118.183 1.00 16.80 C +ATOM 15983 CD2 PHE J 164 33.126 69.631 119.308 1.00 9.62 C +ATOM 15984 CE1 PHE J 164 31.394 71.784 119.244 1.00 18.80 C +ATOM 15985 CE2 PHE J 164 33.081 70.509 120.367 1.00 8.50 C +ATOM 15986 CZ PHE J 164 32.210 71.587 120.334 1.00 12.54 C +ATOM 15987 N VAL J 165 32.625 66.201 118.425 1.00 10.43 N +ATOM 15988 CA VAL J 165 32.844 65.309 119.562 1.00 8.50 C +ATOM 15989 C VAL J 165 33.544 65.965 120.741 1.00 8.50 C +ATOM 15990 O VAL J 165 34.699 66.383 120.631 1.00 12.10 O +ATOM 15991 CB VAL J 165 33.654 64.050 119.125 1.00 13.59 C +ATOM 15992 CG1 VAL J 165 33.769 63.061 120.258 1.00 24.48 C +ATOM 15993 CG2 VAL J 165 32.999 63.372 117.944 1.00 10.76 C +ATOM 15994 N LEU J 166 32.843 66.036 121.871 1.00 8.50 N +ATOM 15995 CA LEU J 166 33.385 66.620 123.094 1.00 8.50 C +ATOM 15996 C LEU J 166 34.570 65.808 123.619 1.00 8.50 C +ATOM 15997 O LEU J 166 34.586 64.591 123.541 1.00 9.95 O +ATOM 15998 CB LEU J 166 32.296 66.669 124.160 1.00 8.50 C +ATOM 15999 CG LEU J 166 31.618 68.001 124.417 1.00 8.50 C +ATOM 16000 CD1 LEU J 166 31.150 68.600 123.118 1.00 15.58 C +ATOM 16001 CD2 LEU J 166 30.475 67.811 125.375 1.00 8.50 C +ATOM 16002 N SER J 167 35.569 66.487 124.145 1.00 8.50 N +ATOM 16003 CA SER J 167 36.717 65.809 124.684 1.00 8.50 C +ATOM 16004 C SER J 167 36.404 65.385 126.111 1.00 9.61 C +ATOM 16005 O SER J 167 35.400 65.791 126.699 1.00 11.81 O +ATOM 16006 CB SER J 167 37.945 66.719 124.635 1.00 8.50 C +ATOM 16007 OG SER J 167 37.870 67.786 125.563 1.00 24.76 O +ATOM 16008 N PRO J 168 37.254 64.546 126.695 1.00 9.06 N +ATOM 16009 CA PRO J 168 37.037 64.081 128.062 1.00 10.38 C +ATOM 16010 C PRO J 168 36.942 65.222 129.063 1.00 12.97 C +ATOM 16011 O PRO J 168 36.127 65.198 129.985 1.00 18.62 O +ATOM 16012 CB PRO J 168 38.264 63.214 128.307 1.00 14.97 C +ATOM 16013 CG PRO J 168 38.509 62.615 126.970 1.00 12.68 C +ATOM 16014 CD PRO J 168 38.375 63.821 126.076 1.00 16.57 C +ATOM 16015 N ASP J 169 37.773 66.234 128.870 1.00 15.31 N +ATOM 16016 CA ASP J 169 37.779 67.384 129.763 1.00 14.92 C +ATOM 16017 C ASP J 169 36.487 68.194 129.626 1.00 15.00 C +ATOM 16018 O ASP J 169 35.924 68.639 130.622 1.00 22.18 O +ATOM 16019 CB ASP J 169 38.997 68.259 129.492 1.00 11.87 C +ATOM 16020 CG ASP J 169 40.306 67.518 129.682 1.00 14.10 C +ATOM 16021 OD1 ASP J 169 40.600 67.112 130.821 1.00 25.72 O +ATOM 16022 OD2 ASP J 169 41.044 67.346 128.690 1.00 22.77 O +ATOM 16023 N GLU J 170 36.008 68.362 128.400 1.00 8.50 N +ATOM 16024 CA GLU J 170 34.788 69.095 128.177 1.00 8.50 C +ATOM 16025 C GLU J 170 33.659 68.273 128.768 1.00 8.50 C +ATOM 16026 O GLU J 170 32.913 68.764 129.600 1.00 12.60 O +ATOM 16027 CB GLU J 170 34.562 69.350 126.685 1.00 8.50 C +ATOM 16028 CG GLU J 170 35.753 70.006 125.984 1.00 16.65 C +ATOM 16029 CD GLU J 170 35.526 70.311 124.497 1.00 28.68 C +ATOM 16030 OE1 GLU J 170 34.647 71.133 124.173 1.00 36.88 O +ATOM 16031 OE2 GLU J 170 36.253 69.752 123.648 1.00 30.66 O +ATOM 16032 N ILE J 171 33.597 66.990 128.427 1.00 11.17 N +ATOM 16033 CA ILE J 171 32.544 66.116 128.928 1.00 11.64 C +ATOM 16034 C ILE J 171 32.508 66.155 130.429 1.00 10.63 C +ATOM 16035 O ILE J 171 31.461 65.998 131.059 1.00 8.50 O +ATOM 16036 CB ILE J 171 32.724 64.693 128.448 1.00 8.50 C +ATOM 16037 CG1 ILE J 171 32.434 64.650 126.963 1.00 8.50 C +ATOM 16038 CG2 ILE J 171 31.772 63.783 129.177 1.00 8.50 C +ATOM 16039 CD1 ILE J 171 32.500 63.306 126.363 1.00 35.26 C +ATOM 16040 N ASN J 172 33.672 66.403 131.000 1.00 17.16 N +ATOM 16041 CA ASN J 172 33.774 66.468 132.435 1.00 19.29 C +ATOM 16042 C ASN J 172 33.158 67.757 132.966 1.00 15.28 C +ATOM 16043 O ASN J 172 32.316 67.710 133.862 1.00 17.78 O +ATOM 16044 CB ASN J 172 35.219 66.317 132.888 1.00 22.70 C +ATOM 16045 CG ASN J 172 35.322 66.242 134.373 1.00 43.61 C +ATOM 16046 OD1 ASN J 172 35.664 67.229 135.038 1.00 48.04 O +ATOM 16047 ND2 ASN J 172 34.944 65.091 134.930 1.00 53.13 N +ATOM 16048 N THR J 173 33.515 68.903 132.391 1.00 9.64 N +ATOM 16049 CA THR J 173 32.945 70.137 132.880 1.00 8.50 C +ATOM 16050 C THR J 173 31.437 70.117 132.693 1.00 8.50 C +ATOM 16051 O THR J 173 30.719 70.523 133.587 1.00 16.68 O +ATOM 16052 CB THR J 173 33.575 71.435 132.267 1.00 8.66 C +ATOM 16053 OG1 THR J 173 32.869 71.821 131.091 1.00 8.50 O +ATOM 16054 CG2 THR J 173 35.048 71.262 131.942 1.00 8.50 C +ATOM 16055 N ILE J 174 30.938 69.616 131.573 1.00 8.50 N +ATOM 16056 CA ILE J 174 29.489 69.565 131.380 1.00 8.50 C +ATOM 16057 C ILE J 174 28.866 68.833 132.566 1.00 9.48 C +ATOM 16058 O ILE J 174 27.854 69.280 133.111 1.00 11.25 O +ATOM 16059 CB ILE J 174 29.061 68.821 130.097 1.00 8.50 C +ATOM 16060 CG1 ILE J 174 29.159 69.711 128.874 1.00 8.50 C +ATOM 16061 CG2 ILE J 174 27.620 68.391 130.199 1.00 8.50 C +ATOM 16062 CD1 ILE J 174 30.537 69.908 128.372 1.00 20.88 C +ATOM 16063 N TYR J 175 29.484 67.720 132.972 1.00 11.00 N +ATOM 16064 CA TYR J 175 28.985 66.928 134.092 1.00 11.94 C +ATOM 16065 C TYR J 175 29.010 67.688 135.399 1.00 18.15 C +ATOM 16066 O TYR J 175 28.004 67.735 136.128 1.00 22.97 O +ATOM 16067 CB TYR J 175 29.792 65.645 134.279 1.00 8.50 C +ATOM 16068 CG TYR J 175 29.363 64.859 135.503 1.00 8.50 C +ATOM 16069 CD1 TYR J 175 28.010 64.529 135.719 1.00 8.50 C +ATOM 16070 CD2 TYR J 175 30.301 64.435 136.431 1.00 8.50 C +ATOM 16071 CE1 TYR J 175 27.612 63.791 136.823 1.00 8.50 C +ATOM 16072 CE2 TYR J 175 29.919 63.700 137.538 1.00 16.94 C +ATOM 16073 CZ TYR J 175 28.572 63.372 137.732 1.00 22.33 C +ATOM 16074 OH TYR J 175 28.190 62.594 138.810 1.00 29.07 O +ATOM 16075 N LEU J 176 30.182 68.247 135.696 1.00 19.48 N +ATOM 16076 CA LEU J 176 30.431 69.012 136.917 1.00 19.81 C +ATOM 16077 C LEU J 176 29.717 70.362 137.024 1.00 25.08 C +ATOM 16078 O LEU J 176 29.754 71.007 138.075 1.00 26.36 O +ATOM 16079 CB LEU J 176 31.930 69.222 137.083 1.00 8.50 C +ATOM 16080 CG LEU J 176 32.600 68.368 138.146 1.00 15.24 C +ATOM 16081 CD1 LEU J 176 31.776 67.109 138.498 1.00 31.52 C +ATOM 16082 CD2 LEU J 176 33.977 68.006 137.646 1.00 13.46 C +ATOM 16083 N GLY J 177 29.081 70.789 135.941 1.00 25.63 N +ATOM 16084 CA GLY J 177 28.379 72.050 135.950 1.00 30.15 C +ATOM 16085 C GLY J 177 29.309 73.204 135.653 1.00 34.25 C +ATOM 16086 O GLY J 177 29.477 74.113 136.455 1.00 45.18 O +ATOM 16087 N GLY J 178 29.977 73.139 134.520 1.00 35.23 N +ATOM 16088 CA GLY J 178 30.857 74.220 134.146 1.00 32.94 C +ATOM 16089 C GLY J 178 30.130 74.979 133.063 1.00 35.01 C +ATOM 16090 O GLY J 178 28.949 74.709 132.801 1.00 35.83 O +ATOM 16091 N PRO J 179 30.770 76.000 132.480 1.00 32.71 N +ATOM 16092 CA PRO J 179 30.136 76.779 131.416 1.00 33.08 C +ATOM 16093 C PRO J 179 30.541 76.231 130.043 1.00 29.80 C +ATOM 16094 O PRO J 179 31.700 75.878 129.829 1.00 32.28 O +ATOM 16095 CB PRO J 179 30.685 78.174 131.669 1.00 35.98 C +ATOM 16096 CG PRO J 179 32.073 77.893 132.113 1.00 24.21 C +ATOM 16097 CD PRO J 179 31.946 76.702 133.020 1.00 23.50 C +ATOM 16098 N PHE J 180 29.587 76.163 129.121 1.00 24.86 N +ATOM 16099 CA PHE J 180 29.835 75.645 127.783 1.00 21.14 C +ATOM 16100 C PHE J 180 28.763 76.188 126.850 1.00 25.50 C +ATOM 16101 O PHE J 180 27.748 76.724 127.314 1.00 25.03 O +ATOM 16102 CB PHE J 180 29.774 74.117 127.789 1.00 11.82 C +ATOM 16103 CG PHE J 180 28.539 73.563 128.449 1.00 11.42 C +ATOM 16104 CD1 PHE J 180 28.510 73.343 129.819 1.00 26.50 C +ATOM 16105 CD2 PHE J 180 27.391 73.323 127.722 1.00 11.49 C +ATOM 16106 CE1 PHE J 180 27.355 72.901 130.448 1.00 22.83 C +ATOM 16107 CE2 PHE J 180 26.244 72.888 128.338 1.00 8.50 C +ATOM 16108 CZ PHE J 180 26.224 72.677 129.700 1.00 16.78 C +ATOM 16109 N SER J 181 28.979 76.024 125.545 1.00 28.51 N +ATOM 16110 CA SER J 181 28.035 76.484 124.530 1.00 26.37 C +ATOM 16111 C SER J 181 27.744 75.459 123.443 1.00 22.18 C +ATOM 16112 O SER J 181 28.569 75.226 122.556 1.00 29.20 O +ATOM 16113 CB SER J 181 28.536 77.775 123.894 1.00 28.65 C +ATOM 16114 OG SER J 181 27.685 78.865 124.218 1.00 49.22 O +ATOM 16115 N PRO J 182 26.583 74.792 123.531 1.00 16.20 N +ATOM 16116 CA PRO J 182 26.151 73.782 122.560 1.00 19.00 C +ATOM 16117 C PRO J 182 25.938 74.486 121.233 1.00 20.07 C +ATOM 16118 O PRO J 182 25.827 75.675 121.218 1.00 30.40 O +ATOM 16119 CB PRO J 182 24.813 73.338 123.127 1.00 13.61 C +ATOM 16120 CG PRO J 182 24.949 73.606 124.579 1.00 11.02 C +ATOM 16121 CD PRO J 182 25.583 74.936 124.593 1.00 8.50 C +ATOM 16122 N ASN J 183 25.896 73.773 120.121 1.00 16.09 N +ATOM 16123 CA ASN J 183 25.677 74.433 118.856 1.00 9.34 C +ATOM 16124 C ASN J 183 24.671 73.747 117.951 1.00 11.21 C +ATOM 16125 O ASN J 183 24.732 73.886 116.737 1.00 23.29 O +ATOM 16126 CB ASN J 183 26.999 74.676 118.134 1.00 11.36 C +ATOM 16127 CG ASN J 183 27.635 73.420 117.631 1.00 8.50 C +ATOM 16128 OD1 ASN J 183 27.232 72.349 117.980 1.00 12.24 O +ATOM 16129 ND2 ASN J 183 28.648 73.556 116.801 1.00 8.68 N +ATOM 16130 N VAL J 184 23.765 72.982 118.548 1.00 8.50 N +ATOM 16131 CA VAL J 184 22.701 72.294 117.828 1.00 8.50 C +ATOM 16132 C VAL J 184 21.466 72.402 118.715 1.00 11.35 C +ATOM 16133 O VAL J 184 20.482 73.051 118.340 1.00 19.38 O +ATOM 16134 CB VAL J 184 23.002 70.812 117.558 1.00 8.50 C +ATOM 16135 CG1 VAL J 184 21.821 70.187 116.843 1.00 8.50 C +ATOM 16136 CG2 VAL J 184 24.241 70.656 116.722 1.00 8.50 C +ATOM 16137 N LEU J 185 21.525 71.795 119.900 1.00 8.50 N +ATOM 16138 CA LEU J 185 20.420 71.854 120.860 1.00 9.34 C +ATOM 16139 C LEU J 185 21.000 72.537 122.071 1.00 8.50 C +ATOM 16140 O LEU J 185 22.067 72.170 122.506 1.00 8.67 O +ATOM 16141 CB LEU J 185 19.902 70.459 121.233 1.00 8.50 C +ATOM 16142 CG LEU J 185 18.493 70.091 120.773 1.00 8.50 C +ATOM 16143 CD1 LEU J 185 18.345 70.377 119.319 1.00 8.50 C +ATOM 16144 CD2 LEU J 185 18.245 68.663 121.019 1.00 8.50 C +ATOM 16145 N ASN J 186 20.322 73.562 122.574 1.00 10.86 N +ATOM 16146 CA ASN J 186 20.801 74.320 123.720 1.00 8.55 C +ATOM 16147 C ASN J 186 19.699 74.435 124.746 1.00 11.63 C +ATOM 16148 O ASN J 186 18.678 75.058 124.480 1.00 18.12 O +ATOM 16149 CB ASN J 186 21.224 75.719 123.271 1.00 8.50 C +ATOM 16150 CG ASN J 186 21.896 76.505 124.365 1.00 8.50 C +ATOM 16151 OD1 ASN J 186 21.664 76.270 125.541 1.00 13.01 O +ATOM 16152 ND2 ASN J 186 22.746 77.433 123.985 1.00 16.82 N +ATOM 16153 N TRP J 187 19.914 73.856 125.922 1.00 10.19 N +ATOM 16154 CA TRP J 187 18.918 73.875 126.994 1.00 10.79 C +ATOM 16155 C TRP J 187 18.619 75.279 127.506 1.00 8.50 C +ATOM 16156 O TRP J 187 17.584 75.530 128.111 1.00 8.50 O +ATOM 16157 CB TRP J 187 19.365 72.967 128.150 1.00 11.88 C +ATOM 16158 CG TRP J 187 18.263 72.559 129.123 1.00 9.45 C +ATOM 16159 CD1 TRP J 187 18.173 72.905 130.432 1.00 8.50 C +ATOM 16160 CD2 TRP J 187 17.109 71.729 128.846 1.00 8.50 C +ATOM 16161 NE1 TRP J 187 17.043 72.357 130.991 1.00 8.50 N +ATOM 16162 CE2 TRP J 187 16.370 71.632 130.048 1.00 8.50 C +ATOM 16163 CE3 TRP J 187 16.635 71.068 127.707 1.00 8.50 C +ATOM 16164 CZ2 TRP J 187 15.187 70.908 130.146 1.00 8.50 C +ATOM 16165 CZ3 TRP J 187 15.453 70.346 127.809 1.00 8.50 C +ATOM 16166 CH2 TRP J 187 14.744 70.273 129.021 1.00 8.50 C +ATOM 16167 N ARG J 188 19.530 76.202 127.252 1.00 11.49 N +ATOM 16168 CA ARG J 188 19.344 77.590 127.690 1.00 18.06 C +ATOM 16169 C ARG J 188 18.547 78.419 126.689 1.00 22.07 C +ATOM 16170 O ARG J 188 18.054 79.488 127.000 1.00 26.69 O +ATOM 16171 CB ARG J 188 20.671 78.287 127.939 1.00 8.50 C +ATOM 16172 CG ARG J 188 20.596 79.371 128.977 1.00 8.50 C +ATOM 16173 CD ARG J 188 21.613 79.087 130.006 1.00 8.50 C +ATOM 16174 NE ARG J 188 22.842 78.718 129.330 1.00 8.50 N +ATOM 16175 CZ ARG J 188 23.857 79.547 129.123 1.00 21.67 C +ATOM 16176 NH1 ARG J 188 23.793 80.810 129.570 1.00 8.50 N +ATOM 16177 NH2 ARG J 188 24.914 79.118 128.423 1.00 23.28 N +ATOM 16178 N ALA J 189 18.435 77.921 125.474 1.00 25.90 N +ATOM 16179 CA ALA J 189 17.697 78.590 124.420 1.00 18.83 C +ATOM 16180 C ALA J 189 16.973 77.476 123.662 1.00 19.11 C +ATOM 16181 O ALA J 189 17.152 77.293 122.460 1.00 23.57 O +ATOM 16182 CB ALA J 189 18.667 79.315 123.500 1.00 15.24 C +ATOM 16183 N LEU J 190 16.180 76.709 124.393 1.00 17.90 N +ATOM 16184 CA LEU J 190 15.449 75.588 123.817 1.00 22.92 C +ATOM 16185 C LEU J 190 14.193 76.063 123.097 1.00 22.64 C +ATOM 16186 O LEU J 190 13.510 76.973 123.554 1.00 19.57 O +ATOM 16187 CB LEU J 190 15.066 74.569 124.911 1.00 9.75 C +ATOM 16188 CG LEU J 190 14.709 73.177 124.410 1.00 8.50 C +ATOM 16189 CD1 LEU J 190 15.976 72.416 124.102 1.00 8.50 C +ATOM 16190 CD2 LEU J 190 13.921 72.470 125.447 1.00 8.50 C +ATOM 16191 N LYS J 191 13.917 75.467 121.945 1.00 28.47 N +ATOM 16192 CA LYS J 191 12.732 75.804 121.161 1.00 26.83 C +ATOM 16193 C LYS J 191 12.004 74.486 121.046 1.00 23.55 C +ATOM 16194 O LYS J 191 12.420 73.607 120.302 1.00 27.93 O +ATOM 16195 CB LYS J 191 13.149 76.324 119.787 1.00 42.86 C +ATOM 16196 CG LYS J 191 12.139 77.268 119.137 1.00 61.93 C +ATOM 16197 CD LYS J 191 12.796 78.117 118.046 1.00 77.87 C +ATOM 16198 CE LYS J 191 11.810 79.114 117.442 1.00 87.23 C +ATOM 16199 NZ LYS J 191 12.474 80.069 116.496 1.00 91.50 N +ATOM 16200 N TYR J 192 10.941 74.328 121.816 1.00 22.00 N +ATOM 16201 CA TYR J 192 10.219 73.062 121.851 1.00 24.72 C +ATOM 16202 C TYR J 192 8.726 73.211 121.739 1.00 27.87 C +ATOM 16203 O TYR J 192 8.205 74.320 121.724 1.00 35.66 O +ATOM 16204 CB TYR J 192 10.528 72.340 123.165 1.00 25.87 C +ATOM 16205 CG TYR J 192 10.068 73.114 124.388 1.00 22.45 C +ATOM 16206 CD1 TYR J 192 10.794 74.223 124.853 1.00 16.98 C +ATOM 16207 CD2 TYR J 192 8.894 72.756 125.065 1.00 16.03 C +ATOM 16208 CE1 TYR J 192 10.359 74.954 125.959 1.00 9.61 C +ATOM 16209 CE2 TYR J 192 8.451 73.481 126.172 1.00 14.47 C +ATOM 16210 CZ TYR J 192 9.190 74.581 126.615 1.00 13.38 C +ATOM 16211 OH TYR J 192 8.744 75.300 127.706 1.00 17.43 O +ATOM 16212 N GLU J 193 8.044 72.074 121.736 1.00 28.84 N +ATOM 16213 CA GLU J 193 6.600 72.028 121.626 1.00 37.02 C +ATOM 16214 C GLU J 193 6.159 70.810 122.433 1.00 35.49 C +ATOM 16215 O GLU J 193 6.606 69.699 122.190 1.00 35.54 O +ATOM 16216 CB GLU J 193 6.201 71.873 120.154 1.00 53.74 C +ATOM 16217 CG GLU J 193 4.752 72.202 119.820 1.00 68.01 C +ATOM 16218 CD GLU J 193 4.464 72.055 118.336 1.00 77.91 C +ATOM 16219 OE1 GLU J 193 4.164 70.922 117.899 1.00 80.24 O +ATOM 16220 OE2 GLU J 193 4.554 73.070 117.607 1.00 86.06 O +ATOM 16221 N VAL J 194 5.318 71.035 123.429 1.00 35.00 N +ATOM 16222 CA VAL J 194 4.835 69.972 124.300 1.00 26.21 C +ATOM 16223 C VAL J 194 3.549 69.418 123.743 1.00 32.14 C +ATOM 16224 O VAL J 194 2.780 70.138 123.102 1.00 40.45 O +ATOM 16225 CB VAL J 194 4.589 70.522 125.717 1.00 28.09 C +ATOM 16226 CG1 VAL J 194 3.879 69.535 126.587 1.00 17.75 C +ATOM 16227 CG2 VAL J 194 5.905 70.922 126.343 1.00 34.62 C +ATOM 16228 N GLN J 195 3.313 68.137 123.997 1.00 32.97 N +ATOM 16229 CA GLN J 195 2.112 67.466 123.524 1.00 33.12 C +ATOM 16230 C GLN J 195 1.684 66.404 124.525 1.00 24.26 C +ATOM 16231 O GLN J 195 2.442 65.509 124.845 1.00 18.77 O +ATOM 16232 CB GLN J 195 2.374 66.811 122.168 1.00 34.58 C +ATOM 16233 CG GLN J 195 1.155 66.730 121.277 1.00 57.01 C +ATOM 16234 CD GLN J 195 0.687 68.103 120.825 1.00 75.64 C +ATOM 16235 OE1 GLN J 195 -0.427 68.536 121.148 1.00 86.48 O +ATOM 16236 NE2 GLN J 195 1.540 68.803 120.081 1.00 76.24 N +ATOM 16237 N GLY J 196 0.477 66.530 125.051 1.00 23.16 N +ATOM 16238 CA GLY J 196 0.007 65.533 125.985 1.00 23.47 C +ATOM 16239 C GLY J 196 0.205 65.866 127.447 1.00 30.02 C +ATOM 16240 O GLY J 196 0.283 67.035 127.835 1.00 41.75 O +ATOM 16241 N GLU J 197 0.292 64.823 128.262 1.00 24.87 N +ATOM 16242 CA GLU J 197 0.449 64.960 129.699 1.00 16.94 C +ATOM 16243 C GLU J 197 1.896 65.152 130.116 1.00 19.03 C +ATOM 16244 O GLU J 197 2.499 64.245 130.689 1.00 28.19 O +ATOM 16245 CB GLU J 197 -0.112 63.727 130.400 1.00 8.50 C +ATOM 16246 CG GLU J 197 -0.326 63.870 131.882 1.00 10.82 C +ATOM 16247 CD GLU J 197 -1.712 64.377 132.241 1.00 22.76 C +ATOM 16248 OE1 GLU J 197 -2.363 65.023 131.397 1.00 23.28 O +ATOM 16249 OE2 GLU J 197 -2.157 64.124 133.380 1.00 27.67 O +ATOM 16250 N VAL J 198 2.465 66.307 129.805 1.00 9.40 N +ATOM 16251 CA VAL J 198 3.824 66.603 130.216 1.00 11.21 C +ATOM 16252 C VAL J 198 3.860 68.019 130.808 1.00 18.18 C +ATOM 16253 O VAL J 198 3.245 68.951 130.268 1.00 19.88 O +ATOM 16254 CB VAL J 198 4.866 66.381 129.086 1.00 8.53 C +ATOM 16255 CG1 VAL J 198 4.171 66.226 127.770 1.00 17.35 C +ATOM 16256 CG2 VAL J 198 5.907 67.514 129.048 1.00 12.72 C +ATOM 16257 N PHE J 199 4.520 68.142 131.961 1.00 17.96 N +ATOM 16258 CA PHE J 199 4.631 69.405 132.685 1.00 15.03 C +ATOM 16259 C PHE J 199 6.083 69.838 132.828 1.00 14.39 C +ATOM 16260 O PHE J 199 7.003 69.034 132.671 1.00 20.91 O +ATOM 16261 CB PHE J 199 4.029 69.251 134.099 1.00 16.42 C +ATOM 16262 CG PHE J 199 2.671 68.596 134.123 1.00 15.65 C +ATOM 16263 CD1 PHE J 199 2.554 67.215 134.155 1.00 11.61 C +ATOM 16264 CD2 PHE J 199 1.513 69.363 134.100 1.00 24.24 C +ATOM 16265 CE1 PHE J 199 1.308 66.605 134.166 1.00 12.72 C +ATOM 16266 CE2 PHE J 199 0.266 68.766 134.108 1.00 23.77 C +ATOM 16267 CZ PHE J 199 0.165 67.378 134.142 1.00 21.00 C +ATOM 16268 N THR J 200 6.280 71.101 133.172 1.00 12.67 N +ATOM 16269 CA THR J 200 7.612 71.646 133.380 1.00 10.77 C +ATOM 16270 C THR J 200 7.713 71.980 134.863 1.00 11.79 C +ATOM 16271 O THR J 200 6.971 72.822 135.362 1.00 22.64 O +ATOM 16272 CB THR J 200 7.809 72.919 132.569 1.00 19.51 C +ATOM 16273 OG1 THR J 200 7.564 72.649 131.176 1.00 28.09 O +ATOM 16274 CG2 THR J 200 9.220 73.451 132.756 1.00 19.94 C +ATOM 16275 N LYS J 201 8.584 71.277 135.574 1.00 12.53 N +ATOM 16276 CA LYS J 201 8.779 71.486 137.008 1.00 8.50 C +ATOM 16277 C LYS J 201 10.265 71.634 137.318 1.00 8.50 C +ATOM 16278 O LYS J 201 11.110 71.398 136.449 1.00 9.93 O +ATOM 16279 CB LYS J 201 8.194 70.321 137.801 1.00 9.05 C +ATOM 16280 CG LYS J 201 6.686 70.199 137.757 1.00 8.70 C +ATOM 16281 CD LYS J 201 6.006 71.483 138.154 1.00 16.42 C +ATOM 16282 CE LYS J 201 4.607 71.245 138.714 1.00 21.49 C +ATOM 16283 NZ LYS J 201 4.665 70.552 140.049 1.00 27.04 N +ATOM 16284 N PRO J 202 10.607 72.066 138.546 1.00 8.50 N +ATOM 16285 CA PRO J 202 12.010 72.245 138.953 1.00 10.98 C +ATOM 16286 C PRO J 202 12.739 70.911 138.973 1.00 11.20 C +ATOM 16287 O PRO J 202 12.205 69.947 139.510 1.00 12.40 O +ATOM 16288 CB PRO J 202 11.884 72.797 140.372 1.00 8.93 C +ATOM 16289 CG PRO J 202 10.564 73.490 140.343 1.00 13.82 C +ATOM 16290 CD PRO J 202 9.700 72.516 139.610 1.00 8.50 C +ATOM 16291 N GLN J 203 13.966 70.864 138.454 1.00 8.50 N +ATOM 16292 CA GLN J 203 14.721 69.619 138.424 1.00 8.50 C +ATOM 16293 C GLN J 203 15.072 69.062 139.785 1.00 8.50 C +ATOM 16294 O GLN J 203 15.449 69.815 140.678 1.00 8.50 O +ATOM 16295 CB GLN J 203 15.991 69.796 137.621 1.00 11.99 C +ATOM 16296 CG GLN J 203 16.933 70.836 138.136 1.00 8.50 C +ATOM 16297 CD GLN J 203 18.196 70.903 137.302 1.00 15.47 C +ATOM 16298 OE1 GLN J 203 19.310 70.914 137.824 1.00 25.11 O +ATOM 16299 NE2 GLN J 203 18.029 70.935 135.989 1.00 24.30 N +ATOM 16300 N LEU J 204 15.006 67.734 139.910 1.00 9.66 N +ATOM 16301 CA LEU J 204 15.308 67.044 141.165 1.00 8.50 C +ATOM 16302 C LEU J 204 16.778 66.769 141.361 1.00 8.50 C +ATOM 16303 O LEU J 204 17.241 66.601 142.487 1.00 13.69 O +ATOM 16304 CB LEU J 204 14.546 65.746 141.281 1.00 8.50 C +ATOM 16305 CG LEU J 204 13.063 65.927 141.054 1.00 8.50 C +ATOM 16306 CD1 LEU J 204 12.821 65.585 139.593 1.00 29.75 C +ATOM 16307 CD2 LEU J 204 12.266 65.032 141.950 1.00 8.50 C +ATOM 16308 N TRP J 205 17.502 66.633 140.265 1.00 8.50 N +ATOM 16309 CA TRP J 205 18.938 66.421 140.349 1.00 16.18 C +ATOM 16310 C TRP J 205 19.542 67.784 140.571 1.00 23.76 C +ATOM 16311 O TRP J 205 18.951 68.788 140.189 1.00 32.82 O +ATOM 16312 CB TRP J 205 19.515 65.794 139.066 1.00 17.64 C +ATOM 16313 CG TRP J 205 18.978 66.337 137.791 1.00 10.15 C +ATOM 16314 CD1 TRP J 205 19.443 67.412 137.103 1.00 8.50 C +ATOM 16315 CD2 TRP J 205 17.845 65.852 137.064 1.00 13.19 C +ATOM 16316 NE1 TRP J 205 18.670 67.641 136.000 1.00 8.50 N +ATOM 16317 CE2 TRP J 205 17.680 66.697 135.945 1.00 12.55 C +ATOM 16318 CE3 TRP J 205 16.947 64.795 137.255 1.00 8.50 C +ATOM 16319 CZ2 TRP J 205 16.655 66.518 135.018 1.00 8.50 C +ATOM 16320 CZ3 TRP J 205 15.937 64.626 136.345 1.00 8.50 C +ATOM 16321 CH2 TRP J 205 15.796 65.482 135.235 1.00 8.50 C +ATOM 16322 N PRO J 206 20.691 67.842 141.253 1.00 29.20 N +ATOM 16323 CA PRO J 206 21.370 69.115 141.528 1.00 31.73 C +ATOM 16324 C PRO J 206 22.198 69.628 140.349 1.00 37.16 C +ATOM 16325 O PRO J 206 22.322 70.871 140.222 1.00 39.35 O +ATOM 16326 CB PRO J 206 22.274 68.758 142.703 1.00 40.89 C +ATOM 16327 CG PRO J 206 22.688 67.339 142.361 1.00 35.62 C +ATOM 16328 CD PRO J 206 21.365 66.724 141.941 1.00 36.55 C +ATOM 16329 OXT PRO J 206 22.746 68.779 139.597 1.00 47.32 O +TER 16330 PRO J 206 +HETATM16331 CA CA A 501 10.142 61.494 60.737 1.00 81.04 CA +HETATM16332 CA CA A 502 12.344 57.906 60.589 1.00 79.94 CA +HETATM16333 CA CA B 501 48.318 40.391 48.186 1.00 84.72 CA +HETATM16334 CA CA B 502 48.931 37.619 45.881 1.00 76.54 CA +HETATM16335 CA CA C 501 49.138 33.991 3.364 1.00 77.85 CA +HETATM16336 CA CA C 502 45.708 33.177 1.832 1.00 76.49 CA +HETATM16337 CA CA E 501 -14.578 67.055 22.550 1.00 78.52 CA +HETATM16338 CA CA E 502 -13.529 64.930 25.945 1.00 74.51 CA +HETATM16339 CA CA F 501 -8.413 52.854 156.014 1.00 77.96 CA +HETATM16340 CA CA F 502 -8.159 50.820 158.996 1.00 33.94 CA +HETATM16341 CA CA G 501 18.706 34.076 186.763 1.00 74.61 CA +HETATM16342 CA CA G 502 20.016 31.400 184.868 1.00 77.56 CA +HETATM16343 CA CA H 501 57.393 22.208 165.568 1.00 99.25 CA +HETATM16344 CA CA H 502 57.228 21.208 162.005 1.00 52.95 CA +HETATM16345 CA CA I 501 53.085 33.400 121.389 1.00 75.60 CA +HETATM16346 CA CA I 502 48.895 32.991 120.039 1.00 36.69 CA +CONECT 282 775 +CONECT 48516331 +CONECT 49216331 +CONECT 49316331 +CONECT 775 282 +CONECT 10901633116332 +CONECT 109116331 +CONECT 109516331 +CONECT 11071633116332 +CONECT 110816332 +CONECT 117916332 +CONECT 1915 2408 +CONECT 212516333 +CONECT 212616333 +CONECT 2408 1915 +CONECT 272216333 +CONECT 27231633316334 +CONECT 272416333 +CONECT 272816333 +CONECT 27401633316334 +CONECT 274116334 +CONECT 281216334 +CONECT 3548 4041 +CONECT 375116335 +CONECT 375816335 +CONECT 375916335 +CONECT 4041 3548 +CONECT 43561633516336 +CONECT 435716335 +CONECT 436116335 +CONECT 43731633516336 +CONECT 437416336 +CONECT 442616336 +CONECT 444516336 +CONECT 5181 5674 +CONECT 5674 5181 +CONECT 6814 7307 +CONECT 701716337 +CONECT 702416337 +CONECT 702516337 +CONECT 7307 6814 +CONECT 76221633716338 +CONECT 762316337 +CONECT 762716337 +CONECT 76391633716338 +CONECT 764016338 +CONECT 771116338 +CONECT 8447 8940 +CONECT 865716339 +CONECT 8940 8447 +CONECT 92551633916340 +CONECT 925616339 +CONECT 92721633916340 +CONECT 927316340 +CONECT 932516340 +CONECT 932616340 +CONECT 934416340 +CONECT1008010573 +CONECT1028316341 +CONECT1029016341 +CONECT1029116341 +CONECT1057310080 +CONECT108881634116342 +CONECT1088916341 +CONECT1089316341 +CONECT109051634116342 +CONECT1090616342 +CONECT1097716342 +CONECT1171312206 +CONECT1191616343 +CONECT1192316343 +CONECT1192416343 +CONECT1220611713 +CONECT125211634316344 +CONECT1252216343 +CONECT1252616343 +CONECT125381634316344 +CONECT1253916344 +CONECT1259216344 +CONECT1261016344 +CONECT1334613839 +CONECT1354916345 +CONECT1355616345 +CONECT1355716345 +CONECT1383913346 +CONECT141541634516346 +CONECT1415516345 +CONECT1415916345 +CONECT141711634516346 +CONECT1417216346 +CONECT1422416346 +CONECT1424316346 +CONECT1497915472 +CONECT1547214979 +CONECT16331 485 492 493 1090 +CONECT16331 1091 1095 1107 +CONECT16332 1090 1107 1108 1179 +CONECT16333 2125 2126 2722 2723 +CONECT16333 2724 2728 2740 +CONECT16334 2723 2740 2741 2812 +CONECT16335 3751 3758 3759 4356 +CONECT16335 4357 4361 4373 +CONECT16336 4356 4373 4374 4426 +CONECT16336 4445 +CONECT16337 7017 7024 7025 7622 +CONECT16337 7623 7627 7639 +CONECT16338 7622 7639 7640 7711 +CONECT16339 8657 9255 9256 9272 +CONECT16340 9255 9272 9273 9325 +CONECT16340 9326 9344 +CONECT1634110283102901029110888 +CONECT16341108891089310905 +CONECT1634210888109051090610977 +CONECT1634311916119231192412521 +CONECT16343125221252612538 +CONECT1634412521125381253912592 +CONECT1634412610 +CONECT1634513549135561355714154 +CONECT16345141551415914171 +CONECT1634614154141711417214224 +CONECT1634614243 +MASTER 600 0 16 36 150 0 26 616336 10 121 160 +END diff --git a/pyaptamer/datasets/data/3eiy.pdb b/pyaptamer/datasets/data/3eiy.pdb deleted file mode 100644 index bdb9625a..00000000 --- a/pyaptamer/datasets/data/3eiy.pdb +++ /dev/null @@ -1,2149 +0,0 @@ -HEADER HYDROLASE 17-SEP-08 3EIY -TITLE CRYSTAL STRUCTURE OF INORGANIC PYROPHOSPHATASE FROM BURKHOLDERIA -TITLE 2 PSEUDOMALLEI WITH BOUND PYROPHOSPHATE -COMPND MOL_ID: 1; -COMPND 2 MOLECULE: INORGANIC PYROPHOSPHATASE; -COMPND 3 CHAIN: A; -COMPND 4 EC: 3.6.1.1; -COMPND 5 ENGINEERED: YES -SOURCE MOL_ID: 1; -SOURCE 2 ORGANISM_SCIENTIFIC: BURKHOLDERIA PSEUDOMALLEI 1710B; -SOURCE 3 ORGANISM_TAXID: 320372; -SOURCE 4 GENE: PPA, BURPS1710B_1237; -SOURCE 5 EXPRESSION_SYSTEM: ESCHERICHIA COLI; -SOURCE 6 EXPRESSION_SYSTEM_TAXID: 562; -SOURCE 7 EXPRESSION_SYSTEM_STRAIN: BL21(DE3); -SOURCE 8 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; -SOURCE 9 EXPRESSION_SYSTEM_PLASMID: AVA0421 -KEYWDS STRUCTURAL GENOMICS, SSGCID, PYROPHOSPHATASE, HYDROLASE, -KEYWDS 2 BUPSA.00023.A, SEATTLE STRUCTURAL GENOMICS CENTER FOR INFECTIOUS -KEYWDS 3 DISEASE' -EXPDTA X-RAY DIFFRACTION -AUTHOR SEATTLE STRUCTURAL GENOMICS CENTER FOR INFECTIOUS DISEASE (SSGCID) -REVDAT 5 21-FEB-24 3EIY 1 REMARK LINK -REVDAT 4 23-OCT-13 3EIY 1 REMARK -REVDAT 3 05-OCT-11 3EIY 1 JRNL VERSN -REVDAT 2 24-FEB-09 3EIY 1 VERSN -REVDAT 1 30-SEP-08 3EIY 0 -JRNL AUTH W.C.VAN VOORHIS,W.G.HOL,P.J.MYLER,L.J.STEWART -JRNL TITL THE ROLE OF MEDICAL STRUCTURAL GENOMICS IN DISCOVERING NEW -JRNL TITL 2 DRUGS FOR INFECTIOUS DISEASES. -JRNL REF PLOS COMPUT BIOL V. 5 00530 2009 -JRNL REFN ISSN 1553-734X -JRNL PMID 19855826 -JRNL DOI 10.1371/JOURNAL.PCBI.1000530 -REMARK 1 -REMARK 1 REFERENCE 1 -REMARK 1 AUTH L.BAUGH,L.A.GALLAGHER,R.PATRAPUVICH,M.C.CLIFTON, -REMARK 1 AUTH 2 A.S.GARDBERG,T.E.EDWARDS,B.ARMOUR,D.W.BEGLEY,S.H.DIETERICH, -REMARK 1 AUTH 3 D.M.DRANOW,J.ABENDROTH,J.W.FAIRMAN,D.FOX,B.L.STAKER,I.PHAN, -REMARK 1 AUTH 4 A.GILLESPIE,R.CHOI,S.NAKAZAWA-HEWITT,M.T.NGUYEN,A.NAPULI, -REMARK 1 AUTH 5 L.BARRETT,G.W.BUCHKO,R.STACY,P.J.MYLER,L.J.STEWART,C.MANOIL, -REMARK 1 AUTH 6 W.C.VAN VOORHIS -REMARK 1 TITL COMBINING FUNCTIONAL AND STRUCTURAL GENOMICS TO SAMPLE THE -REMARK 1 TITL 2 ESSENTIAL BURKHOLDERIA STRUCTOME. -REMARK 1 REF PLOS ONE V. 8 53851 2013 -REMARK 1 REFN ESSN 1932-6203 -REMARK 1 PMID 23382856 -REMARK 1 DOI 10.1371/JOURNAL.PONE.0053851 -REMARK 2 -REMARK 2 RESOLUTION. 2.10 ANGSTROMS. -REMARK 3 -REMARK 3 REFINEMENT. -REMARK 3 PROGRAM : REFMAC 5.4.0067 -REMARK 3 AUTHORS : MURSHUDOV,SKUBAK,LEBEDEV,PANNU,STEINER, -REMARK 3 : NICHOLLS,WINN,LONG,VAGIN -REMARK 3 -REMARK 3 REFINEMENT TARGET : MAXIMUM LIKELIHOOD -REMARK 3 -REMARK 3 DATA USED IN REFINEMENT. -REMARK 3 RESOLUTION RANGE HIGH (ANGSTROMS) : 2.10 -REMARK 3 RESOLUTION RANGE LOW (ANGSTROMS) : 50.00 -REMARK 3 DATA CUTOFF (SIGMA(F)) : 0.000 -REMARK 3 COMPLETENESS FOR RANGE (%) : NULL -REMARK 3 NUMBER OF REFLECTIONS : 19547 -REMARK 3 -REMARK 3 FIT TO DATA USED IN REFINEMENT. -REMARK 3 CROSS-VALIDATION METHOD : THROUGHOUT -REMARK 3 FREE R VALUE TEST SET SELECTION : RANDOM -REMARK 3 R VALUE (WORKING + TEST SET) : 0.213 -REMARK 3 R VALUE (WORKING SET) : 0.211 -REMARK 3 FREE R VALUE : 0.249 -REMARK 3 FREE R VALUE TEST SET SIZE (%) : 5.100 -REMARK 3 FREE R VALUE TEST SET COUNT : 991 -REMARK 3 -REMARK 3 FIT IN THE HIGHEST RESOLUTION BIN. -REMARK 3 TOTAL NUMBER OF BINS USED : 20 -REMARK 3 BIN RESOLUTION RANGE HIGH (A) : 2.10 -REMARK 3 BIN RESOLUTION RANGE LOW (A) : 2.15 -REMARK 3 REFLECTION IN BIN (WORKING SET) : 1250 -REMARK 3 BIN COMPLETENESS (WORKING+TEST) (%) : 90.60 -REMARK 3 BIN R VALUE (WORKING SET) : 0.3090 -REMARK 3 BIN FREE R VALUE SET COUNT : 71 -REMARK 3 BIN FREE R VALUE : 0.4070 -REMARK 3 -REMARK 3 NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT. -REMARK 3 PROTEIN ATOMS : 1330 -REMARK 3 NUCLEIC ACID ATOMS : 0 -REMARK 3 HETEROGEN ATOMS : 39 -REMARK 3 SOLVENT ATOMS : 112 -REMARK 3 -REMARK 3 B VALUES. -REMARK 3 FROM WILSON PLOT (A**2) : NULL -REMARK 3 MEAN B VALUE (OVERALL, A**2) : 30.12 -REMARK 3 OVERALL ANISOTROPIC B VALUE. -REMARK 3 B11 (A**2) : 0.80000 -REMARK 3 B22 (A**2) : 0.80000 -REMARK 3 B33 (A**2) : -1.21000 -REMARK 3 B12 (A**2) : 0.40000 -REMARK 3 B13 (A**2) : 0.00000 -REMARK 3 B23 (A**2) : 0.00000 -REMARK 3 -REMARK 3 ESTIMATED OVERALL COORDINATE ERROR. -REMARK 3 ESU BASED ON R VALUE (A): 0.156 -REMARK 3 ESU BASED ON FREE R VALUE (A): 0.152 -REMARK 3 ESU BASED ON MAXIMUM LIKELIHOOD (A): 0.110 -REMARK 3 ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 4.164 -REMARK 3 -REMARK 3 CORRELATION COEFFICIENTS. -REMARK 3 CORRELATION COEFFICIENT FO-FC : 0.948 -REMARK 3 CORRELATION COEFFICIENT FO-FC FREE : 0.929 -REMARK 3 -REMARK 3 RMS DEVIATIONS FROM IDEAL VALUES COUNT RMS WEIGHT -REMARK 3 BOND LENGTHS REFINED ATOMS (A): 1393 ; 0.015 ; 0.022 -REMARK 3 BOND LENGTHS OTHERS (A): NULL ; NULL ; NULL -REMARK 3 BOND ANGLES REFINED ATOMS (DEGREES): 1886 ; 1.460 ; 1.994 -REMARK 3 BOND ANGLES OTHERS (DEGREES): NULL ; NULL ; NULL -REMARK 3 TORSION ANGLES, PERIOD 1 (DEGREES): 173 ; 5.857 ; 5.000 -REMARK 3 TORSION ANGLES, PERIOD 2 (DEGREES): 56 ;32.570 ;25.357 -REMARK 3 TORSION ANGLES, PERIOD 3 (DEGREES): 222 ;15.203 ;15.000 -REMARK 3 TORSION ANGLES, PERIOD 4 (DEGREES): 4 ;18.890 ;15.000 -REMARK 3 CHIRAL-CENTER RESTRAINTS (A**3): 209 ; 0.092 ; 0.200 -REMARK 3 GENERAL PLANES REFINED ATOMS (A): 1034 ; 0.007 ; 0.021 -REMARK 3 GENERAL PLANES OTHERS (A): NULL ; NULL ; NULL -REMARK 3 NON-BONDED CONTACTS REFINED ATOMS (A): NULL ; NULL ; NULL -REMARK 3 NON-BONDED CONTACTS OTHERS (A): NULL ; NULL ; NULL -REMARK 3 NON-BONDED TORSION REFINED ATOMS (A): NULL ; NULL ; NULL -REMARK 3 NON-BONDED TORSION OTHERS (A): NULL ; NULL ; NULL -REMARK 3 H-BOND (X...Y) REFINED ATOMS (A): NULL ; NULL ; NULL -REMARK 3 H-BOND (X...Y) OTHERS (A): NULL ; NULL ; NULL -REMARK 3 POTENTIAL METAL-ION REFINED ATOMS (A): NULL ; NULL ; NULL -REMARK 3 POTENTIAL METAL-ION OTHERS (A): NULL ; NULL ; NULL -REMARK 3 SYMMETRY VDW REFINED ATOMS (A): NULL ; NULL ; NULL -REMARK 3 SYMMETRY VDW OTHERS (A): NULL ; NULL ; NULL -REMARK 3 SYMMETRY H-BOND REFINED ATOMS (A): NULL ; NULL ; NULL -REMARK 3 SYMMETRY H-BOND OTHERS (A): NULL ; NULL ; NULL -REMARK 3 SYMMETRY METAL-ION REFINED ATOMS (A): NULL ; NULL ; NULL -REMARK 3 SYMMETRY METAL-ION OTHERS (A): NULL ; NULL ; NULL -REMARK 3 -REMARK 3 ISOTROPIC THERMAL FACTOR RESTRAINTS. COUNT RMS WEIGHT -REMARK 3 MAIN-CHAIN BOND REFINED ATOMS (A**2): 870 ; 0.890 ; 1.500 -REMARK 3 MAIN-CHAIN BOND OTHER ATOMS (A**2): NULL ; NULL ; NULL -REMARK 3 MAIN-CHAIN ANGLE REFINED ATOMS (A**2): 1408 ; 1.604 ; 2.000 -REMARK 3 MAIN-CHAIN ANGLE OTHER ATOMS (A**2): NULL ; NULL ; NULL -REMARK 3 SIDE-CHAIN BOND REFINED ATOMS (A**2): 523 ; 2.198 ; 3.000 -REMARK 3 SIDE-CHAIN BOND OTHER ATOMS (A**2): NULL ; NULL ; NULL -REMARK 3 SIDE-CHAIN ANGLE REFINED ATOMS (A**2): 478 ; 3.551 ; 4.500 -REMARK 3 SIDE-CHAIN ANGLE OTHER ATOMS (A**2): NULL ; NULL ; NULL -REMARK 3 LONG RANGE B REFINED ATOMS (A**2): NULL ; NULL ; NULL -REMARK 3 LONG RANGE B OTHER ATOMS (A**2): NULL ; NULL ; NULL -REMARK 3 -REMARK 3 ANISOTROPIC THERMAL FACTOR RESTRAINTS. COUNT RMS WEIGHT -REMARK 3 RIGID-BOND RESTRAINTS (A**2): NULL ; NULL ; NULL -REMARK 3 SPHERICITY; FREE ATOMS (A**2): NULL ; NULL ; NULL -REMARK 3 SPHERICITY; BONDED ATOMS (A**2): NULL ; NULL ; NULL -REMARK 3 -REMARK 3 NCS RESTRAINTS STATISTICS -REMARK 3 NUMBER OF DIFFERENT NCS GROUPS : NULL -REMARK 3 -REMARK 3 TLS DETAILS -REMARK 3 NUMBER OF TLS GROUPS : NULL -REMARK 3 -REMARK 3 BULK SOLVENT MODELLING. -REMARK 3 METHOD USED : MASK -REMARK 3 PARAMETERS FOR MASK CALCULATION -REMARK 3 VDW PROBE RADIUS : 1.20 -REMARK 3 ION PROBE RADIUS : 0.80 -REMARK 3 SHRINKAGE RADIUS : 0.80 -REMARK 3 -REMARK 3 OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN ADDED IN THE RIDING -REMARK 3 POSITIONS -REMARK 4 -REMARK 4 3EIY COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 -REMARK 100 -REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 18-SEP-08. -REMARK 100 THE DEPOSITION ID IS D_1000049380. -REMARK 200 -REMARK 200 EXPERIMENTAL DETAILS -REMARK 200 EXPERIMENT TYPE : X-RAY DIFFRACTION -REMARK 200 DATE OF DATA COLLECTION : 04-SEP-08 -REMARK 200 TEMPERATURE (KELVIN) : 100.0 -REMARK 200 PH : 6.30 -REMARK 200 NUMBER OF CRYSTALS USED : 1 -REMARK 200 -REMARK 200 SYNCHROTRON (Y/N) : N -REMARK 200 RADIATION SOURCE : ROTATING ANODE -REMARK 200 BEAMLINE : NULL -REMARK 200 X-RAY GENERATOR MODEL : RIGAKU MICROMAX-007 HF -REMARK 200 MONOCHROMATIC OR LAUE (M/L) : M -REMARK 200 WAVELENGTH OR RANGE (A) : 1.5418 -REMARK 200 MONOCHROMATOR : NULL -REMARK 200 OPTICS : NULL -REMARK 200 -REMARK 200 DETECTOR TYPE : CCD -REMARK 200 DETECTOR MANUFACTURER : RIGAKU SATURN 944 -REMARK 200 INTENSITY-INTEGRATION SOFTWARE : HKL-2000 -REMARK 200 DATA SCALING SOFTWARE : HKL-2000 -REMARK 200 -REMARK 200 NUMBER OF UNIQUE REFLECTIONS : 19792 -REMARK 200 RESOLUTION RANGE HIGH (A) : 2.100 -REMARK 200 RESOLUTION RANGE LOW (A) : 50.000 -REMARK 200 REJECTION CRITERIA (SIGMA(I)) : NULL -REMARK 200 -REMARK 200 OVERALL. -REMARK 200 COMPLETENESS FOR RANGE (%) : 98.7 -REMARK 200 DATA REDUNDANCY : 3.600 -REMARK 200 R MERGE (I) : 0.10300 -REMARK 200 R SYM (I) : NULL -REMARK 200 FOR THE DATA SET : 8.9000 -REMARK 200 -REMARK 200 IN THE HIGHEST RESOLUTION SHELL. -REMARK 200 HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.10 -REMARK 200 HIGHEST RESOLUTION SHELL, RANGE LOW (A) : 2.18 -REMARK 200 COMPLETENESS FOR SHELL (%) : 98.5 -REMARK 200 DATA REDUNDANCY IN SHELL : 2.70 -REMARK 200 R MERGE FOR SHELL (I) : 0.66900 -REMARK 200 R SYM FOR SHELL (I) : NULL -REMARK 200 FOR SHELL : NULL -REMARK 200 -REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH -REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT -REMARK 200 SOFTWARE USED: MOLREP -REMARK 200 STARTING MODEL: NULL -REMARK 200 -REMARK 200 REMARK: NULL -REMARK 280 -REMARK 280 CRYSTAL -REMARK 280 SOLVENT CONTENT, VS (%): 67.71 -REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 3.81 -REMARK 280 -REMARK 280 CRYSTALLIZATION CONDITIONS: 100 MM NA/K PHOSPHATE, PH 6.3, 49.5% -REMARK 280 PEG 200. CRYSTAL 3 MONTHS OLD., PH 6.30, VAPOR DIFFUSION, -REMARK 280 SITTING DROP, TEMPERATURE 289K -REMARK 290 -REMARK 290 CRYSTALLOGRAPHIC SYMMETRY -REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 63 2 2 -REMARK 290 -REMARK 290 SYMOP SYMMETRY -REMARK 290 NNNMMM OPERATOR -REMARK 290 1555 X,Y,Z -REMARK 290 2555 -Y,X-Y,Z -REMARK 290 3555 -X+Y,-X,Z -REMARK 290 4555 -X,-Y,Z+1/2 -REMARK 290 5555 Y,-X+Y,Z+1/2 -REMARK 290 6555 X-Y,X,Z+1/2 -REMARK 290 7555 Y,X,-Z -REMARK 290 8555 X-Y,-Y,-Z -REMARK 290 9555 -X,-X+Y,-Z -REMARK 290 10555 -Y,-X,-Z+1/2 -REMARK 290 11555 -X+Y,Y,-Z+1/2 -REMARK 290 12555 X,X-Y,-Z+1/2 -REMARK 290 -REMARK 290 WHERE NNN -> OPERATOR NUMBER -REMARK 290 MMM -> TRANSLATION VECTOR -REMARK 290 -REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS -REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM -REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY -REMARK 290 RELATED MOLECULES. -REMARK 290 SMTRY1 1 1.000000 0.000000 0.000000 0.00000 -REMARK 290 SMTRY2 1 0.000000 1.000000 0.000000 0.00000 -REMARK 290 SMTRY3 1 0.000000 0.000000 1.000000 0.00000 -REMARK 290 SMTRY1 2 -0.500000 -0.866025 0.000000 0.00000 -REMARK 290 SMTRY2 2 0.866025 -0.500000 0.000000 0.00000 -REMARK 290 SMTRY3 2 0.000000 0.000000 1.000000 0.00000 -REMARK 290 SMTRY1 3 -0.500000 0.866025 0.000000 0.00000 -REMARK 290 SMTRY2 3 -0.866025 -0.500000 0.000000 0.00000 -REMARK 290 SMTRY3 3 0.000000 0.000000 1.000000 0.00000 -REMARK 290 SMTRY1 4 -1.000000 0.000000 0.000000 0.00000 -REMARK 290 SMTRY2 4 0.000000 -1.000000 0.000000 0.00000 -REMARK 290 SMTRY3 4 0.000000 0.000000 1.000000 55.61650 -REMARK 290 SMTRY1 5 0.500000 0.866025 0.000000 0.00000 -REMARK 290 SMTRY2 5 -0.866025 0.500000 0.000000 0.00000 -REMARK 290 SMTRY3 5 0.000000 0.000000 1.000000 55.61650 -REMARK 290 SMTRY1 6 0.500000 -0.866025 0.000000 0.00000 -REMARK 290 SMTRY2 6 0.866025 0.500000 0.000000 0.00000 -REMARK 290 SMTRY3 6 0.000000 0.000000 1.000000 55.61650 -REMARK 290 SMTRY1 7 -0.500000 0.866025 0.000000 0.00000 -REMARK 290 SMTRY2 7 0.866025 0.500000 0.000000 0.00000 -REMARK 290 SMTRY3 7 0.000000 0.000000 -1.000000 0.00000 -REMARK 290 SMTRY1 8 1.000000 0.000000 0.000000 0.00000 -REMARK 290 SMTRY2 8 0.000000 -1.000000 0.000000 0.00000 -REMARK 290 SMTRY3 8 0.000000 0.000000 -1.000000 0.00000 -REMARK 290 SMTRY1 9 -0.500000 -0.866025 0.000000 0.00000 -REMARK 290 SMTRY2 9 -0.866025 0.500000 0.000000 0.00000 -REMARK 290 SMTRY3 9 0.000000 0.000000 -1.000000 0.00000 -REMARK 290 SMTRY1 10 0.500000 -0.866025 0.000000 0.00000 -REMARK 290 SMTRY2 10 -0.866025 -0.500000 0.000000 0.00000 -REMARK 290 SMTRY3 10 0.000000 0.000000 -1.000000 55.61650 -REMARK 290 SMTRY1 11 -1.000000 0.000000 0.000000 0.00000 -REMARK 290 SMTRY2 11 0.000000 1.000000 0.000000 0.00000 -REMARK 290 SMTRY3 11 0.000000 0.000000 -1.000000 55.61650 -REMARK 290 SMTRY1 12 0.500000 0.866025 0.000000 0.00000 -REMARK 290 SMTRY2 12 0.866025 -0.500000 0.000000 0.00000 -REMARK 290 SMTRY3 12 0.000000 0.000000 -1.000000 55.61650 -REMARK 290 -REMARK 290 REMARK: NULL -REMARK 300 -REMARK 300 BIOMOLECULE: 1, 2, 3 -REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM -REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN -REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON -REMARK 300 BURIED SURFACE AREA. -REMARK 350 -REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN -REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE -REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS -REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND -REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. -REMARK 350 -REMARK 350 BIOMOLECULE: 1 -REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: HEXAMERIC -REMARK 350 SOFTWARE USED: PISA -REMARK 350 TOTAL BURIED SURFACE AREA: 20130 ANGSTROM**2 -REMARK 350 SURFACE AREA OF THE COMPLEX: 37680 ANGSTROM**2 -REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -208.0 KCAL/MOL -REMARK 350 APPLY THE FOLLOWING TO CHAINS: A -REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 -REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 -REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 -REMARK 350 BIOMT1 2 -0.500000 -0.866025 0.000000 50.47600 -REMARK 350 BIOMT2 2 0.866025 -0.500000 0.000000 87.42700 -REMARK 350 BIOMT3 2 0.000000 0.000000 1.000000 0.00000 -REMARK 350 BIOMT1 3 -0.500000 0.866025 0.000000 -50.47600 -REMARK 350 BIOMT2 3 -0.866025 -0.500000 0.000000 87.42700 -REMARK 350 BIOMT3 3 0.000000 0.000000 1.000000 0.00000 -REMARK 350 BIOMT1 4 0.500000 -0.866025 0.000000 50.47600 -REMARK 350 BIOMT2 4 -0.866025 -0.500000 0.000000 87.42700 -REMARK 350 BIOMT3 4 0.000000 0.000000 -1.000000 55.61650 -REMARK 350 BIOMT1 5 -1.000000 0.000000 0.000000 0.00000 -REMARK 350 BIOMT2 5 0.000000 1.000000 0.000000 0.00000 -REMARK 350 BIOMT3 5 0.000000 0.000000 -1.000000 55.61650 -REMARK 350 BIOMT1 6 0.500000 0.866025 0.000000 -50.47600 -REMARK 350 BIOMT2 6 0.866025 -0.500000 0.000000 87.42700 -REMARK 350 BIOMT3 6 0.000000 0.000000 -1.000000 55.61650 -REMARK 350 -REMARK 350 BIOMOLECULE: 2 -REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: TRIMERIC -REMARK 350 SOFTWARE USED: PISA -REMARK 350 TOTAL BURIED SURFACE AREA: 7740 ANGSTROM**2 -REMARK 350 SURFACE AREA OF THE COMPLEX: 21160 ANGSTROM**2 -REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -92.0 KCAL/MOL -REMARK 350 APPLY THE FOLLOWING TO CHAINS: A -REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 -REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 -REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 -REMARK 350 BIOMT1 2 -0.500000 -0.866025 0.000000 50.47600 -REMARK 350 BIOMT2 2 0.866025 -0.500000 0.000000 87.42700 -REMARK 350 BIOMT3 2 0.000000 0.000000 1.000000 0.00000 -REMARK 350 BIOMT1 3 -0.500000 0.866025 0.000000 -50.47600 -REMARK 350 BIOMT2 3 -0.866025 -0.500000 0.000000 87.42700 -REMARK 350 BIOMT3 3 0.000000 0.000000 1.000000 0.00000 -REMARK 350 -REMARK 350 BIOMOLECULE: 3 -REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC -REMARK 350 APPLY THE FOLLOWING TO CHAINS: A -REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 -REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 -REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 -REMARK 375 -REMARK 375 SPECIAL POSITION -REMARK 375 THE FOLLOWING ATOMS ARE FOUND TO BE WITHIN 0.15 ANGSTROMS -REMARK 375 OF A SYMMETRY RELATED ATOM AND ARE ASSUMED TO BE ON SPECIAL -REMARK 375 POSITIONS. -REMARK 375 -REMARK 375 ATOM RES CSSEQI -REMARK 375 K K A 176 LIES ON A SPECIAL POSITION. -REMARK 465 -REMARK 465 MISSING RESIDUES -REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE -REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN -REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) -REMARK 465 -REMARK 465 M RES C SSSEQI -REMARK 465 MET A -20 -REMARK 465 ALA A -19 -REMARK 465 HIS A -18 -REMARK 465 HIS A -17 -REMARK 465 HIS A -16 -REMARK 465 HIS A -15 -REMARK 465 HIS A -14 -REMARK 465 HIS A -13 -REMARK 465 MET A -12 -REMARK 465 GLY A -11 -REMARK 465 THR A -10 -REMARK 465 LEU A -9 -REMARK 465 GLU A -8 -REMARK 465 ALA A -7 -REMARK 465 GLN A -6 -REMARK 465 THR A -5 -REMARK 465 GLN A -4 -REMARK 465 GLY A -3 -REMARK 465 PRO A -2 -REMARK 465 GLY A -1 -REMARK 465 SER A 0 -REMARK 465 MET A 1 -REMARK 470 -REMARK 470 MISSING ATOM -REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER; -REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; -REMARK 470 I=INSERTION CODE): -REMARK 470 M RES CSSEQI ATOMS -REMARK 470 LYS A 113 CG CD CE NZ -REMARK 470 LYS A 147 CG CD CE NZ -REMARK 470 LYS A 152 CG CD CE NZ -REMARK 500 -REMARK 500 GEOMETRY AND STEREOCHEMISTRY -REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT -REMARK 500 -REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT. -REMARK 500 -REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE -REMARK 500 O HOH A 238 O HOH A 281 2.06 -REMARK 500 -REMARK 500 REMARK: NULL -REMARK 500 -REMARK 500 GEOMETRY AND STEREOCHEMISTRY -REMARK 500 SUBTOPIC: TORSION ANGLES -REMARK 500 -REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: -REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; -REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). -REMARK 500 -REMARK 500 STANDARD TABLE: -REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) -REMARK 500 -REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- -REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 -REMARK 500 -REMARK 500 M RES CSSEQI PSI PHI -REMARK 500 ASP A 11 81.33 -159.79 -REMARK 500 ASP A 98 -168.63 -122.40 -REMARK 500 -REMARK 500 REMARK: NULL -REMARK 620 -REMARK 620 METAL COORDINATION -REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; -REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE): -REMARK 620 -REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL -REMARK 620 K A 176 K -REMARK 620 N RES CSSEQI ATOM -REMARK 620 1 ASP A 11 OD1 -REMARK 620 2 LEU A 12 O 92.8 -REMARK 620 3 GLN A 14 OE1 100.9 87.2 -REMARK 620 N 1 2 -REMARK 620 -REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL -REMARK 620 NA A 178 NA -REMARK 620 N RES CSSEQI ATOM -REMARK 620 1 ASP A 71 OD2 -REMARK 620 2 ASP A 103 OD1 94.9 -REMARK 620 3 ALA A 104 O 102.5 85.4 -REMARK 620 4 HOH A 245 O 72.2 146.6 127.0 -REMARK 620 5 HOH A 247 O 169.6 95.4 79.9 98.2 -REMARK 620 6 HOH A 263 O 85.2 155.0 70.3 56.8 86.0 -REMARK 620 N 1 2 3 4 5 -REMARK 620 -REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL -REMARK 620 NA A 177 NA -REMARK 620 N RES CSSEQI ATOM -REMARK 620 1 ASP A 98 OD2 -REMARK 620 2 ASP A 103 OD2 91.4 -REMARK 620 3 POP A 179 O6 93.1 172.2 -REMARK 620 4 POP A 179 O3 165.9 100.0 76.6 -REMARK 620 5 HOH A 201 O 89.4 88.0 85.7 99.2 -REMARK 620 6 HOH A 257 O 78.3 74.9 112.2 96.5 158.6 -REMARK 620 N 1 2 3 4 5 -REMARK 800 -REMARK 800 SITE -REMARK 800 SITE_IDENTIFIER: AC1 -REMARK 800 EVIDENCE_CODE: SOFTWARE -REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE K A 176 -REMARK 800 -REMARK 800 SITE_IDENTIFIER: AC2 -REMARK 800 EVIDENCE_CODE: SOFTWARE -REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NA A 177 -REMARK 800 -REMARK 800 SITE_IDENTIFIER: AC3 -REMARK 800 EVIDENCE_CODE: SOFTWARE -REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NA A 178 -REMARK 800 -REMARK 800 SITE_IDENTIFIER: AC4 -REMARK 800 EVIDENCE_CODE: SOFTWARE -REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE POP A 179 -REMARK 800 -REMARK 800 SITE_IDENTIFIER: AC5 -REMARK 800 EVIDENCE_CODE: SOFTWARE -REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE PG4 A 180 -REMARK 800 -REMARK 800 SITE_IDENTIFIER: AC6 -REMARK 800 EVIDENCE_CODE: SOFTWARE -REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE PEG A 181 -REMARK 800 -REMARK 800 SITE_IDENTIFIER: AC7 -REMARK 800 EVIDENCE_CODE: SOFTWARE -REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE PEG A 182 -REMARK 900 -REMARK 900 RELATED ENTRIES -REMARK 900 RELATED ID: BUPSA.00023.A RELATED DB: TARGETDB -REMARK 900 RELATED ID: 3D63 RELATED DB: PDB -REMARK 900 THE SAME PROTEIN, "OPEN" CONFORMATION, APO FORM, IN SPACE GROUP -REMARK 900 P21212 -REMARK 900 RELATED ID: 3EIZ RELATED DB: PDB -REMARK 900 RELATED ID: 3EJ0 RELATED DB: PDB -REMARK 900 RELATED ID: 3EJ2 RELATED DB: PDB -DBREF 3EIY A 1 175 UNP Q3JUV5 Q3JUV5_BURP1 1 175 -SEQADV 3EIY MET A -20 UNP Q3JUV5 EXPRESSION TAG -SEQADV 3EIY ALA A -19 UNP Q3JUV5 EXPRESSION TAG -SEQADV 3EIY HIS A -18 UNP Q3JUV5 EXPRESSION TAG -SEQADV 3EIY HIS A -17 UNP Q3JUV5 EXPRESSION TAG -SEQADV 3EIY HIS A -16 UNP Q3JUV5 EXPRESSION TAG -SEQADV 3EIY HIS A -15 UNP Q3JUV5 EXPRESSION TAG -SEQADV 3EIY HIS A -14 UNP Q3JUV5 EXPRESSION TAG -SEQADV 3EIY HIS A -13 UNP Q3JUV5 EXPRESSION TAG -SEQADV 3EIY MET A -12 UNP Q3JUV5 EXPRESSION TAG -SEQADV 3EIY GLY A -11 UNP Q3JUV5 EXPRESSION TAG -SEQADV 3EIY THR A -10 UNP Q3JUV5 EXPRESSION TAG -SEQADV 3EIY LEU A -9 UNP Q3JUV5 EXPRESSION TAG -SEQADV 3EIY GLU A -8 UNP Q3JUV5 EXPRESSION TAG -SEQADV 3EIY ALA A -7 UNP Q3JUV5 EXPRESSION TAG -SEQADV 3EIY GLN A -6 UNP Q3JUV5 EXPRESSION TAG -SEQADV 3EIY THR A -5 UNP Q3JUV5 EXPRESSION TAG -SEQADV 3EIY GLN A -4 UNP Q3JUV5 EXPRESSION TAG -SEQADV 3EIY GLY A -3 UNP Q3JUV5 EXPRESSION TAG -SEQADV 3EIY PRO A -2 UNP Q3JUV5 EXPRESSION TAG -SEQADV 3EIY GLY A -1 UNP Q3JUV5 EXPRESSION TAG -SEQADV 3EIY SER A 0 UNP Q3JUV5 EXPRESSION TAG -SEQRES 1 A 196 MET ALA HIS HIS HIS HIS HIS HIS MET GLY THR LEU GLU -SEQRES 2 A 196 ALA GLN THR GLN GLY PRO GLY SER MET SER PHE SER ASN -SEQRES 3 A 196 VAL PRO ALA GLY LYS ASP LEU PRO GLN ASP PHE ASN VAL -SEQRES 4 A 196 ILE ILE GLU ILE PRO ALA GLN SER GLU PRO VAL LYS TYR -SEQRES 5 A 196 GLU ALA ASP LYS ALA LEU GLY LEU LEU VAL VAL ASP ARG -SEQRES 6 A 196 PHE ILE GLY THR GLY MET ARG TYR PRO VAL ASN TYR GLY -SEQRES 7 A 196 PHE ILE PRO GLN THR LEU SER GLY ASP GLY ASP PRO VAL -SEQRES 8 A 196 ASP VAL LEU VAL ILE THR PRO PHE PRO LEU LEU ALA GLY -SEQRES 9 A 196 SER VAL VAL ARG ALA ARG ALA LEU GLY MET LEU LYS MET -SEQRES 10 A 196 THR ASP GLU SER GLY VAL ASP ALA LYS LEU VAL ALA VAL -SEQRES 11 A 196 PRO HIS ASP LYS VAL CYS PRO MET THR ALA ASN LEU LYS -SEQRES 12 A 196 SER ILE ASP ASP VAL PRO ALA TYR LEU LYS ASP GLN ILE -SEQRES 13 A 196 LYS HIS PHE PHE GLU GLN TYR LYS ALA LEU GLU LYS GLY -SEQRES 14 A 196 LYS TRP VAL LYS VAL GLU GLY TRP ASP GLY ILE ASP ALA -SEQRES 15 A 196 ALA HIS LYS GLU ILE THR ASP GLY VAL ALA ASN PHE LYS -SEQRES 16 A 196 LYS -HET K A 176 1 -HET NA A 177 1 -HET NA A 178 1 -HET POP A 179 9 -HET PG4 A 180 13 -HET PEG A 181 7 -HET PEG A 182 7 -HETNAM K POTASSIUM ION -HETNAM NA SODIUM ION -HETNAM POP PYROPHOSPHATE 2- -HETNAM PG4 TETRAETHYLENE GLYCOL -HETNAM PEG DI(HYDROXYETHYL)ETHER -FORMUL 2 K K 1+ -FORMUL 3 NA 2(NA 1+) -FORMUL 5 POP H2 O7 P2 2- -FORMUL 6 PG4 C8 H18 O5 -FORMUL 7 PEG 2(C4 H10 O3) -FORMUL 9 HOH *112(H2 O) -HELIX 1 1 SER A 2 VAL A 6 5 5 -HELIX 2 2 CYS A 115 ALA A 119 5 5 -HELIX 3 3 SER A 123 VAL A 127 5 5 -HELIX 4 4 PRO A 128 TYR A 142 1 15 -HELIX 5 5 GLY A 158 LYS A 175 1 18 -SHEET 1 A 7 VAL A 151 ASP A 157 0 -SHEET 2 A 7 VAL A 85 ASP A 98 -1 N LYS A 95 O GLY A 155 -SHEET 3 A 7 GLY A 101 PRO A 110 -1 O LYS A 105 N LEU A 94 -SHEET 4 A 7 VAL A 70 VAL A 74 1 N LEU A 73 O ALA A 108 -SHEET 5 A 7 ASN A 55 ILE A 59 -1 N GLY A 57 O VAL A 72 -SHEET 6 A 7 PHE A 16 ILE A 22 -1 N ILE A 19 O PHE A 58 -SHEET 7 A 7 VAL A 85 ASP A 98 -1 O ALA A 88 N PHE A 16 -SHEET 1 B 2 VAL A 29 ASP A 34 0 -SHEET 2 B 2 LEU A 39 PHE A 45 -1 O LEU A 39 N ASP A 34 -LINK OD1 ASP A 11 K K A 176 1555 1555 2.73 -LINK O LEU A 12 K K A 176 1555 1555 2.65 -LINK OE1 GLN A 14 K K A 176 1555 1555 2.92 -LINK OD2 ASP A 71 NA NA A 178 1555 1555 2.81 -LINK OD2 ASP A 98 NA NA A 177 1555 1555 2.65 -LINK OD2 ASP A 103 NA NA A 177 1555 1555 2.58 -LINK OD1 ASP A 103 NA NA A 178 1555 1555 2.53 -LINK O ALA A 104 NA NA A 178 1555 1555 2.92 -LINK NA NA A 177 O6 POP A 179 1555 1555 2.56 -LINK NA NA A 177 O3 POP A 179 1555 1555 2.20 -LINK NA NA A 177 O HOH A 201 1555 1555 2.50 -LINK NA NA A 177 O HOH A 257 1555 1555 2.65 -LINK NA NA A 178 O HOH A 245 1555 1555 2.66 -LINK NA NA A 178 O HOH A 247 1555 1555 2.86 -LINK NA NA A 178 O HOH A 263 1555 1555 2.50 -CISPEP 1 LEU A 12 PRO A 13 0 -0.44 -SITE 1 AC1 3 ASP A 11 LEU A 12 GLN A 14 -SITE 1 AC2 6 ASP A 98 ASP A 103 LYS A 143 POP A 179 -SITE 2 AC2 6 HOH A 201 HOH A 257 -SITE 1 AC3 7 ASP A 66 ASP A 71 ASP A 103 ALA A 104 -SITE 2 AC3 7 HOH A 245 HOH A 247 HOH A 263 -SITE 1 AC4 14 LYS A 30 ARG A 44 TYR A 56 ASP A 103 -SITE 2 AC4 14 LYS A 105 TYR A 142 LYS A 143 NA A 177 -SITE 3 AC4 14 HOH A 200 HOH A 221 HOH A 238 HOH A 239 -SITE 4 AC4 14 HOH A 260 HOH A 267 -SITE 1 AC5 7 GLY A 9 LYS A 10 ASP A 11 LEU A 12 -SITE 2 AC5 7 GLN A 14 ASP A 160 HIS A 163 -SITE 1 AC6 4 LYS A 136 VAL A 153 GLU A 154 TRP A 156 -SITE 1 AC7 3 ARG A 87 LYS A 113 VAL A 114 -CRYST1 100.952 100.952 111.233 90.00 90.00 120.00 P 63 2 2 12 -ORIGX1 1.000000 0.000000 0.000000 0.00000 -ORIGX2 0.000000 1.000000 0.000000 0.00000 -ORIGX3 0.000000 0.000000 1.000000 0.00000 -SCALE1 0.009906 0.005719 0.000000 0.00000 -SCALE2 0.000000 0.011438 0.000000 0.00000 -SCALE3 0.000000 0.000000 0.008990 0.00000 -ATOM 1 N SER A 2 2.527 54.656 -1.667 1.00 52.73 N -ATOM 2 CA SER A 2 3.259 54.783 -0.368 1.00 52.54 C -ATOM 3 C SER A 2 4.127 53.553 -0.105 1.00 52.03 C -ATOM 4 O SER A 2 5.274 53.451 -0.594 1.00 52.45 O -ATOM 5 CB SER A 2 2.273 54.944 0.792 1.00 52.69 C -ATOM 6 OG SER A 2 2.066 56.306 1.121 1.00 54.37 O -ATOM 7 N PHE A 3 3.563 52.626 0.674 1.00 50.61 N -ATOM 8 CA PHE A 3 4.261 51.413 1.102 1.00 48.73 C -ATOM 9 C PHE A 3 4.881 50.670 -0.064 1.00 48.17 C -ATOM 10 O PHE A 3 6.035 50.257 0.019 1.00 47.56 O -ATOM 11 CB PHE A 3 3.342 50.479 1.896 1.00 47.95 C -ATOM 12 CG PHE A 3 2.747 51.112 3.120 1.00 46.23 C -ATOM 13 CD1 PHE A 3 3.425 52.100 3.804 1.00 43.75 C -ATOM 14 CD2 PHE A 3 1.509 50.701 3.594 1.00 45.77 C -ATOM 15 CE1 PHE A 3 2.893 52.679 4.942 1.00 44.62 C -ATOM 16 CE2 PHE A 3 0.955 51.280 4.728 1.00 45.65 C -ATOM 17 CZ PHE A 3 1.655 52.273 5.409 1.00 45.91 C -ATOM 18 N SER A 4 4.122 50.518 -1.151 1.00 47.69 N -ATOM 19 CA SER A 4 4.593 49.745 -2.323 1.00 47.00 C -ATOM 20 C SER A 4 5.896 50.254 -2.977 1.00 45.29 C -ATOM 21 O SER A 4 6.627 49.479 -3.592 1.00 45.34 O -ATOM 22 CB SER A 4 3.489 49.633 -3.387 1.00 47.47 C -ATOM 23 OG SER A 4 3.169 50.916 -3.908 1.00 49.92 O -ATOM 24 N ASN A 5 6.184 51.544 -2.832 1.00 43.32 N -ATOM 25 CA ASN A 5 7.351 52.145 -3.480 1.00 41.42 C -ATOM 26 C ASN A 5 8.584 52.307 -2.574 1.00 39.00 C -ATOM 27 O ASN A 5 9.629 52.802 -3.000 1.00 38.69 O -ATOM 28 CB ASN A 5 6.958 53.491 -4.094 1.00 42.02 C -ATOM 29 CG ASN A 5 6.108 53.321 -5.366 1.00 45.67 C -ATOM 30 OD1 ASN A 5 4.862 53.286 -5.312 1.00 48.48 O -ATOM 31 ND2 ASN A 5 6.784 53.176 -6.513 1.00 47.35 N -ATOM 32 N VAL A 6 8.466 51.922 -1.312 1.00 35.70 N -ATOM 33 CA VAL A 6 9.636 51.959 -0.457 1.00 32.41 C -ATOM 34 C VAL A 6 10.595 50.807 -0.862 1.00 30.30 C -ATOM 35 O VAL A 6 10.176 49.658 -0.964 1.00 29.28 O -ATOM 36 CB VAL A 6 9.242 51.846 1.038 1.00 32.26 C -ATOM 37 CG1 VAL A 6 10.476 51.902 1.905 1.00 30.72 C -ATOM 38 CG2 VAL A 6 8.257 52.934 1.415 1.00 30.80 C -ATOM 39 N PRO A 7 11.890 51.109 -1.064 1.00 28.73 N -ATOM 40 CA PRO A 7 12.827 50.031 -1.447 1.00 27.85 C -ATOM 41 C PRO A 7 12.952 49.030 -0.321 1.00 26.92 C -ATOM 42 O PRO A 7 12.827 49.397 0.859 1.00 26.32 O -ATOM 43 CB PRO A 7 14.159 50.763 -1.644 1.00 27.56 C -ATOM 44 CG PRO A 7 13.784 52.193 -1.869 1.00 28.99 C -ATOM 45 CD PRO A 7 12.550 52.421 -1.016 1.00 28.59 C -ATOM 46 N ALA A 8 13.208 47.777 -0.660 1.00 26.04 N -ATOM 47 CA ALA A 8 13.463 46.785 0.378 1.00 25.67 C -ATOM 48 C ALA A 8 14.702 47.145 1.205 1.00 25.55 C -ATOM 49 O ALA A 8 14.786 46.804 2.395 1.00 25.75 O -ATOM 50 CB ALA A 8 13.588 45.395 -0.224 1.00 25.25 C -ATOM 51 N GLY A 9 15.668 47.834 0.598 1.00 25.34 N -ATOM 52 CA GLY A 9 16.864 48.237 1.344 1.00 25.46 C -ATOM 53 C GLY A 9 17.905 48.951 0.506 1.00 26.30 C -ATOM 54 O GLY A 9 17.865 48.854 -0.717 1.00 26.99 O -ATOM 55 N LYS A 10 18.834 49.654 1.159 1.00 26.15 N -ATOM 56 CA LYS A 10 19.941 50.322 0.477 1.00 27.63 C -ATOM 57 C LYS A 10 21.104 49.348 0.102 1.00 27.17 C -ATOM 58 O LYS A 10 21.920 49.640 -0.769 1.00 28.04 O -ATOM 59 CB LYS A 10 20.522 51.442 1.352 1.00 27.27 C -ATOM 60 CG LYS A 10 19.619 52.654 1.569 1.00 32.65 C -ATOM 61 CD LYS A 10 20.334 53.690 2.451 1.00 38.46 C -ATOM 62 CE LYS A 10 19.720 55.094 2.319 1.00 42.10 C -ATOM 63 NZ LYS A 10 18.235 55.016 2.421 1.00 42.82 N -ATOM 64 N ASP A 11 21.204 48.221 0.782 1.00 26.40 N -ATOM 65 CA ASP A 11 22.265 47.261 0.452 1.00 25.76 C -ATOM 66 C ASP A 11 21.901 45.893 0.979 1.00 24.71 C -ATOM 67 O ASP A 11 22.369 45.488 2.037 1.00 25.14 O -ATOM 68 CB ASP A 11 23.639 47.723 0.995 1.00 25.24 C -ATOM 69 CG ASP A 11 24.809 47.007 0.321 1.00 26.43 C -ATOM 70 OD1 ASP A 11 24.583 45.956 -0.326 1.00 25.79 O -ATOM 71 OD2 ASP A 11 25.973 47.447 0.460 1.00 27.48 O -ATOM 72 N LEU A 12 21.065 45.188 0.225 1.00 24.00 N -ATOM 73 CA LEU A 12 20.522 43.892 0.629 1.00 24.17 C -ATOM 74 C LEU A 12 21.527 42.731 0.574 1.00 24.26 C -ATOM 75 O LEU A 12 22.415 42.717 -0.279 1.00 23.90 O -ATOM 76 CB LEU A 12 19.327 43.549 -0.255 1.00 23.47 C -ATOM 77 CG LEU A 12 18.183 44.559 -0.124 1.00 24.51 C -ATOM 78 CD1 LEU A 12 17.245 44.405 -1.303 1.00 24.49 C -ATOM 79 CD2 LEU A 12 17.457 44.315 1.204 1.00 21.79 C -ATOM 80 N PRO A 13 21.386 41.743 1.476 1.00 24.36 N -ATOM 81 CA PRO A 13 20.351 41.670 2.533 1.00 24.17 C -ATOM 82 C PRO A 13 20.685 42.375 3.838 1.00 24.39 C -ATOM 83 O PRO A 13 19.834 42.426 4.711 1.00 25.43 O -ATOM 84 CB PRO A 13 20.288 40.158 2.827 1.00 23.15 C -ATOM 85 CG PRO A 13 21.729 39.721 2.577 1.00 24.50 C -ATOM 86 CD PRO A 13 22.089 40.451 1.320 1.00 23.40 C -ATOM 87 N GLN A 14 21.914 42.858 4.024 1.00 24.55 N -ATOM 88 CA GLN A 14 22.326 43.248 5.367 1.00 24.52 C -ATOM 89 C GLN A 14 21.819 44.648 5.828 1.00 24.75 C -ATOM 90 O GLN A 14 21.677 44.894 7.030 1.00 24.93 O -ATOM 91 CB GLN A 14 23.855 43.075 5.569 1.00 24.43 C -ATOM 92 CG GLN A 14 24.713 44.188 5.026 1.00 23.98 C -ATOM 93 CD GLN A 14 25.043 43.985 3.535 1.00 28.20 C -ATOM 94 OE1 GLN A 14 24.581 43.009 2.886 1.00 24.90 O -ATOM 95 NE2 GLN A 14 25.852 44.905 2.978 1.00 26.11 N -ATOM 96 N ASP A 15 21.564 45.534 4.870 1.00 23.84 N -ATOM 97 CA ASP A 15 21.118 46.909 5.116 1.00 24.38 C -ATOM 98 C ASP A 15 19.713 47.043 4.478 1.00 23.69 C -ATOM 99 O ASP A 15 19.595 47.207 3.252 1.00 24.21 O -ATOM 100 CB ASP A 15 22.139 47.858 4.480 1.00 23.38 C -ATOM 101 CG ASP A 15 21.822 49.319 4.698 1.00 26.33 C -ATOM 102 OD1 ASP A 15 20.881 49.684 5.451 1.00 27.50 O -ATOM 103 OD2 ASP A 15 22.525 50.140 4.100 1.00 26.80 O -ATOM 104 N PHE A 16 18.663 46.860 5.294 1.00 23.31 N -ATOM 105 CA PHE A 16 17.273 46.837 4.816 1.00 23.19 C -ATOM 106 C PHE A 16 16.304 47.845 5.526 1.00 23.35 C -ATOM 107 O PHE A 16 16.611 48.396 6.589 1.00 23.52 O -ATOM 108 CB PHE A 16 16.708 45.420 4.913 1.00 22.15 C -ATOM 109 CG PHE A 16 16.755 44.850 6.304 1.00 23.52 C -ATOM 110 CD1 PHE A 16 15.651 44.981 7.178 1.00 21.74 C -ATOM 111 CD2 PHE A 16 17.894 44.177 6.749 1.00 21.69 C -ATOM 112 CE1 PHE A 16 15.692 44.448 8.458 1.00 23.07 C -ATOM 113 CE2 PHE A 16 17.962 43.648 8.041 1.00 21.56 C -ATOM 114 CZ PHE A 16 16.870 43.770 8.903 1.00 22.24 C -ATOM 115 N ASN A 17 15.127 48.049 4.936 1.00 23.34 N -ATOM 116 CA ASN A 17 14.124 48.961 5.479 1.00 22.99 C -ATOM 117 C ASN A 17 12.974 48.168 6.088 1.00 22.52 C -ATOM 118 O ASN A 17 12.615 47.109 5.587 1.00 21.94 O -ATOM 119 CB ASN A 17 13.567 49.872 4.354 1.00 24.37 C -ATOM 120 CG ASN A 17 14.635 50.818 3.792 1.00 24.52 C -ATOM 121 OD1 ASN A 17 15.483 51.296 4.541 1.00 26.24 O -ATOM 122 ND2 ASN A 17 14.609 51.063 2.469 1.00 22.96 N -ATOM 123 N VAL A 18 12.406 48.688 7.175 1.00 22.23 N -ATOM 124 CA VAL A 18 11.233 48.079 7.822 1.00 20.84 C -ATOM 125 C VAL A 18 10.145 49.150 7.953 1.00 20.77 C -ATOM 126 O VAL A 18 10.375 50.259 8.466 1.00 20.23 O -ATOM 127 CB VAL A 18 11.556 47.505 9.264 1.00 21.36 C -ATOM 128 CG1 VAL A 18 10.350 46.768 9.827 1.00 19.07 C -ATOM 129 CG2 VAL A 18 12.803 46.559 9.236 1.00 19.34 C -ATOM 130 N ILE A 19 8.968 48.830 7.446 1.00 20.63 N -ATOM 131 CA ILE A 19 7.808 49.672 7.712 1.00 21.06 C -ATOM 132 C ILE A 19 7.109 49.163 8.967 1.00 20.14 C -ATOM 133 O ILE A 19 6.763 47.954 9.057 1.00 19.42 O -ATOM 134 CB ILE A 19 6.841 49.673 6.498 1.00 22.11 C -ATOM 135 CG1 ILE A 19 7.500 50.469 5.349 1.00 22.28 C -ATOM 136 CG2 ILE A 19 5.467 50.272 6.876 1.00 19.98 C -ATOM 137 CD1 ILE A 19 6.887 50.180 3.973 1.00 24.13 C -ATOM 138 N ILE A 20 6.914 50.062 9.937 1.00 19.07 N -ATOM 139 CA ILE A 20 6.335 49.641 11.228 1.00 18.73 C -ATOM 140 C ILE A 20 4.808 49.541 11.151 1.00 19.01 C -ATOM 141 O ILE A 20 4.148 50.500 10.726 1.00 20.15 O -ATOM 142 CB ILE A 20 6.767 50.609 12.367 1.00 18.68 C -ATOM 143 CG1 ILE A 20 8.310 50.664 12.407 1.00 18.52 C -ATOM 144 CG2 ILE A 20 6.131 50.202 13.761 1.00 17.94 C -ATOM 145 CD1 ILE A 20 8.972 49.240 12.614 1.00 16.95 C -ATOM 146 N GLU A 21 4.251 48.404 11.563 1.00 18.77 N -ATOM 147 CA GLU A 21 2.788 48.243 11.677 1.00 19.87 C -ATOM 148 C GLU A 21 2.290 48.373 13.130 1.00 19.89 C -ATOM 149 O GLU A 21 1.226 48.954 13.377 1.00 20.64 O -ATOM 150 CB GLU A 21 2.343 46.896 11.092 1.00 19.24 C -ATOM 151 CG GLU A 21 2.620 46.756 9.582 1.00 21.01 C -ATOM 152 CD GLU A 21 2.500 45.327 9.118 1.00 22.65 C -ATOM 153 OE1 GLU A 21 3.120 44.447 9.729 1.00 26.58 O -ATOM 154 OE2 GLU A 21 1.771 45.072 8.153 1.00 23.20 O -ATOM 155 N ILE A 22 3.076 47.870 14.079 1.00 19.73 N -ATOM 156 CA ILE A 22 2.667 47.809 15.505 1.00 19.94 C -ATOM 157 C ILE A 22 3.788 48.237 16.456 1.00 19.81 C -ATOM 158 O ILE A 22 4.767 47.517 16.605 1.00 21.37 O -ATOM 159 CB ILE A 22 2.182 46.370 15.899 1.00 20.44 C -ATOM 160 CG1 ILE A 22 1.021 45.935 15.009 1.00 19.03 C -ATOM 161 CG2 ILE A 22 1.789 46.307 17.367 1.00 19.40 C -ATOM 162 CD1 ILE A 22 0.659 44.455 15.118 1.00 19.72 C -ATOM 163 N PRO A 23 3.672 49.434 17.073 1.00 19.24 N -ATOM 164 CA PRO A 23 4.714 49.919 18.016 1.00 18.94 C -ATOM 165 C PRO A 23 4.816 48.987 19.246 1.00 19.28 C -ATOM 166 O PRO A 23 3.819 48.398 19.666 1.00 19.56 O -ATOM 167 CB PRO A 23 4.201 51.308 18.436 1.00 18.92 C -ATOM 168 CG PRO A 23 3.286 51.728 17.295 1.00 17.76 C -ATOM 169 CD PRO A 23 2.608 50.421 16.861 1.00 17.40 C -ATOM 170 N ALA A 24 6.026 48.803 19.761 1.00 18.68 N -ATOM 171 CA ALA A 24 6.227 48.079 21.006 1.00 18.54 C -ATOM 172 C ALA A 24 5.270 48.569 22.090 1.00 18.10 C -ATOM 173 O ALA A 24 5.137 49.785 22.277 1.00 18.29 O -ATOM 174 CB ALA A 24 7.660 48.250 21.486 1.00 17.41 C -ATOM 175 N GLN A 25 4.623 47.639 22.805 1.00 17.44 N -ATOM 176 CA GLN A 25 3.743 48.001 23.972 1.00 18.87 C -ATOM 177 C GLN A 25 2.476 48.811 23.642 1.00 18.88 C -ATOM 178 O GLN A 25 1.787 49.325 24.541 1.00 19.08 O -ATOM 179 CB GLN A 25 4.570 48.733 25.062 1.00 18.70 C -ATOM 180 CG GLN A 25 5.715 47.839 25.644 1.00 19.85 C -ATOM 181 CD GLN A 25 5.192 46.588 26.346 1.00 22.15 C -ATOM 182 OE1 GLN A 25 4.040 46.540 26.806 1.00 25.01 O -ATOM 183 NE2 GLN A 25 6.035 45.573 26.446 1.00 22.42 N -ATOM 184 N SER A 26 2.145 48.938 22.364 1.00 19.33 N -ATOM 185 CA SER A 26 0.912 49.648 21.988 1.00 19.59 C -ATOM 186 C SER A 26 -0.320 48.844 22.464 1.00 20.50 C -ATOM 187 O SER A 26 -0.237 47.623 22.727 1.00 20.29 O -ATOM 188 CB SER A 26 0.884 49.925 20.458 1.00 19.67 C -ATOM 189 OG SER A 26 1.003 48.706 19.704 1.00 19.08 O -ATOM 190 N GLU A 27 -1.464 49.514 22.603 1.00 20.38 N -ATOM 191 CA GLU A 27 -2.696 48.815 22.968 1.00 21.73 C -ATOM 192 C GLU A 27 -2.899 47.630 22.013 1.00 21.32 C -ATOM 193 O GLU A 27 -2.468 47.677 20.875 1.00 21.54 O -ATOM 194 CB GLU A 27 -3.896 49.808 23.027 1.00 21.74 C -ATOM 195 CG GLU A 27 -3.758 50.649 24.300 1.00 23.24 C -ATOM 196 CD GLU A 27 -4.826 51.710 24.535 1.00 25.87 C -ATOM 197 OE1 GLU A 27 -5.477 52.149 23.596 1.00 25.51 O -ATOM 198 OE2 GLU A 27 -5.000 52.130 25.698 1.00 25.72 O -ATOM 199 N PRO A 28 -3.555 46.560 22.480 1.00 21.62 N -ATOM 200 CA PRO A 28 -3.561 45.259 21.771 1.00 21.72 C -ATOM 201 C PRO A 28 -4.457 45.171 20.496 1.00 22.43 C -ATOM 202 O PRO A 28 -5.421 44.391 20.437 1.00 22.00 O -ATOM 203 CB PRO A 28 -4.038 44.271 22.855 1.00 21.26 C -ATOM 204 CG PRO A 28 -4.768 45.110 23.839 1.00 21.70 C -ATOM 205 CD PRO A 28 -4.153 46.479 23.829 1.00 21.25 C -ATOM 206 N VAL A 29 -4.098 45.952 19.485 1.00 23.11 N -ATOM 207 CA VAL A 29 -4.811 46.024 18.207 1.00 23.26 C -ATOM 208 C VAL A 29 -3.804 45.704 17.111 1.00 23.88 C -ATOM 209 O VAL A 29 -2.754 46.345 17.004 1.00 23.18 O -ATOM 210 CB VAL A 29 -5.430 47.448 17.974 1.00 23.27 C -ATOM 211 CG1 VAL A 29 -6.368 47.470 16.769 1.00 21.69 C -ATOM 212 CG2 VAL A 29 -6.114 47.970 19.256 1.00 22.25 C -ATOM 213 N LYS A 30 -4.115 44.681 16.315 1.00 24.89 N -ATOM 214 CA LYS A 30 -3.209 44.200 15.259 1.00 26.06 C -ATOM 215 C LYS A 30 -3.450 44.954 13.937 1.00 26.00 C -ATOM 216 O LYS A 30 -4.425 44.686 13.244 1.00 26.59 O -ATOM 217 CB LYS A 30 -3.467 42.692 15.077 1.00 26.61 C -ATOM 218 CG LYS A 30 -2.248 41.822 14.884 1.00 28.45 C -ATOM 219 CD LYS A 30 -1.999 41.562 13.421 1.00 28.74 C -ATOM 220 CE LYS A 30 -0.999 40.442 13.240 1.00 30.16 C -ATOM 221 NZ LYS A 30 -0.274 40.696 11.977 1.00 28.79 N -ATOM 222 N TYR A 31 -2.613 45.936 13.595 1.00 25.80 N -ATOM 223 CA TYR A 31 -2.729 46.580 12.294 1.00 25.22 C -ATOM 224 C TYR A 31 -1.864 45.867 11.261 1.00 27.00 C -ATOM 225 O TYR A 31 -0.798 45.336 11.598 1.00 26.61 O -ATOM 226 CB TYR A 31 -2.308 48.046 12.361 1.00 25.12 C -ATOM 227 CG TYR A 31 -3.212 48.892 13.226 1.00 23.08 C -ATOM 228 CD1 TYR A 31 -4.287 49.571 12.673 1.00 19.20 C -ATOM 229 CD2 TYR A 31 -3.015 48.958 14.603 1.00 18.39 C -ATOM 230 CE1 TYR A 31 -5.114 50.341 13.448 1.00 19.06 C -ATOM 231 CE2 TYR A 31 -3.845 49.730 15.405 1.00 20.45 C -ATOM 232 CZ TYR A 31 -4.898 50.419 14.815 1.00 18.45 C -ATOM 233 OH TYR A 31 -5.738 51.188 15.591 1.00 21.38 O -ATOM 234 N GLU A 32 -2.333 45.871 10.016 1.00 27.55 N -ATOM 235 CA GLU A 32 -1.576 45.372 8.868 1.00 30.56 C -ATOM 236 C GLU A 32 -1.594 46.427 7.779 1.00 30.42 C -ATOM 237 O GLU A 32 -2.638 46.991 7.484 1.00 30.34 O -ATOM 238 CB GLU A 32 -2.173 44.050 8.322 1.00 31.34 C -ATOM 239 CG GLU A 32 -2.005 42.866 9.281 1.00 36.06 C -ATOM 240 CD GLU A 32 -2.344 41.526 8.649 1.00 43.47 C -ATOM 241 OE1 GLU A 32 -2.926 41.513 7.531 1.00 44.52 O -ATOM 242 OE2 GLU A 32 -2.042 40.483 9.294 1.00 47.61 O -ATOM 243 N ALA A 33 -0.434 46.703 7.200 1.00 31.88 N -ATOM 244 CA ALA A 33 -0.345 47.623 6.073 1.00 33.76 C -ATOM 245 C ALA A 33 -1.055 47.022 4.860 1.00 35.50 C -ATOM 246 O ALA A 33 -0.894 45.835 4.550 1.00 36.09 O -ATOM 247 CB ALA A 33 1.091 47.937 5.747 1.00 33.39 C -ATOM 248 N ASP A 34 -1.890 47.820 4.207 1.00 36.96 N -ATOM 249 CA ASP A 34 -2.438 47.426 2.914 1.00 38.49 C -ATOM 250 C ASP A 34 -1.577 48.087 1.835 1.00 39.63 C -ATOM 251 O ASP A 34 -1.554 49.309 1.686 1.00 38.98 O -ATOM 252 CB ASP A 34 -3.896 47.845 2.800 1.00 38.53 C -ATOM 253 CG ASP A 34 -4.540 47.355 1.528 1.00 39.38 C -ATOM 254 OD1 ASP A 34 -4.180 47.841 0.442 1.00 37.36 O -ATOM 255 OD2 ASP A 34 -5.405 46.469 1.619 1.00 42.57 O -ATOM 256 N LYS A 35 -0.810 47.282 1.120 1.00 41.54 N -ATOM 257 CA LYS A 35 0.108 47.856 0.134 1.00 44.05 C -ATOM 258 C LYS A 35 -0.633 48.369 -1.124 1.00 44.94 C -ATOM 259 O LYS A 35 -0.100 49.187 -1.886 1.00 45.87 O -ATOM 260 CB LYS A 35 1.242 46.868 -0.197 1.00 44.78 C -ATOM 261 CG LYS A 35 2.517 47.072 0.672 1.00 44.98 C -ATOM 262 CD LYS A 35 2.936 45.792 1.403 1.00 45.99 C -ATOM 263 CE LYS A 35 1.747 45.213 2.158 1.00 47.71 C -ATOM 264 NZ LYS A 35 2.070 44.230 3.257 1.00 48.24 N -ATOM 265 N ALA A 36 -1.873 47.914 -1.313 1.00 44.65 N -ATOM 266 CA ALA A 36 -2.707 48.405 -2.391 1.00 44.81 C -ATOM 267 C ALA A 36 -3.519 49.652 -2.006 1.00 44.91 C -ATOM 268 O ALA A 36 -4.046 50.317 -2.886 1.00 45.28 O -ATOM 269 CB ALA A 36 -3.656 47.309 -2.864 1.00 44.78 C -ATOM 270 N LEU A 37 -3.680 49.937 -0.708 1.00 43.77 N -ATOM 271 CA LEU A 37 -4.397 51.142 -0.298 1.00 42.57 C -ATOM 272 C LEU A 37 -3.404 52.197 0.145 1.00 41.06 C -ATOM 273 O LEU A 37 -3.735 53.383 0.193 1.00 41.20 O -ATOM 274 CB LEU A 37 -5.379 50.861 0.844 1.00 42.92 C -ATOM 275 CG LEU A 37 -6.450 49.797 0.612 1.00 43.81 C -ATOM 276 CD1 LEU A 37 -7.367 49.636 1.818 1.00 44.72 C -ATOM 277 CD2 LEU A 37 -7.258 50.154 -0.608 1.00 45.97 C -ATOM 278 N GLY A 38 -2.183 51.759 0.469 1.00 39.85 N -ATOM 279 CA GLY A 38 -1.176 52.617 1.131 1.00 37.63 C -ATOM 280 C GLY A 38 -1.501 53.016 2.583 1.00 36.28 C -ATOM 281 O GLY A 38 -1.003 54.034 3.081 1.00 36.55 O -ATOM 282 N LEU A 39 -2.339 52.234 3.265 1.00 33.68 N -ATOM 283 CA LEU A 39 -2.850 52.621 4.595 1.00 31.37 C -ATOM 284 C LEU A 39 -2.765 51.448 5.548 1.00 29.37 C -ATOM 285 O LEU A 39 -2.761 50.301 5.099 1.00 28.58 O -ATOM 286 CB LEU A 39 -4.311 53.094 4.516 1.00 30.92 C -ATOM 287 CG LEU A 39 -4.593 54.380 3.727 1.00 31.84 C -ATOM 288 CD1 LEU A 39 -6.088 54.592 3.563 1.00 31.37 C -ATOM 289 CD2 LEU A 39 -3.950 55.577 4.413 1.00 30.83 C -ATOM 290 N LEU A 40 -2.685 51.738 6.854 1.00 27.18 N -ATOM 291 CA LEU A 40 -2.802 50.690 7.873 1.00 26.07 C -ATOM 292 C LEU A 40 -4.260 50.295 8.039 1.00 24.63 C -ATOM 293 O LEU A 40 -5.140 51.150 8.125 1.00 23.26 O -ATOM 294 CB LEU A 40 -2.218 51.115 9.238 1.00 25.71 C -ATOM 295 CG LEU A 40 -0.687 51.351 9.263 1.00 25.93 C -ATOM 296 CD1 LEU A 40 -0.250 52.020 10.547 1.00 24.92 C -ATOM 297 CD2 LEU A 40 0.064 50.039 9.032 1.00 24.73 C -ATOM 298 N VAL A 41 -4.486 48.988 8.093 1.00 24.43 N -ATOM 299 CA VAL A 41 -5.822 48.433 8.262 1.00 25.12 C -ATOM 300 C VAL A 41 -5.926 47.622 9.556 1.00 25.36 C -ATOM 301 O VAL A 41 -4.999 46.846 9.885 1.00 24.93 O -ATOM 302 CB VAL A 41 -6.155 47.533 7.039 1.00 25.41 C -ATOM 303 CG1 VAL A 41 -7.438 46.711 7.244 1.00 26.79 C -ATOM 304 CG2 VAL A 41 -6.270 48.406 5.797 1.00 24.02 C -ATOM 305 N VAL A 42 -7.038 47.774 10.285 1.00 24.79 N -ATOM 306 CA VAL A 42 -7.232 46.981 11.515 1.00 25.06 C -ATOM 307 C VAL A 42 -7.535 45.513 11.174 1.00 25.94 C -ATOM 308 O VAL A 42 -8.638 45.197 10.731 1.00 26.93 O -ATOM 309 CB VAL A 42 -8.420 47.451 12.370 1.00 24.99 C -ATOM 310 CG1 VAL A 42 -8.436 46.718 13.688 1.00 24.48 C -ATOM 311 CG2 VAL A 42 -8.400 48.939 12.607 1.00 24.84 C -ATOM 312 N ASP A 43 -6.578 44.619 11.376 1.00 25.33 N -ATOM 313 CA ASP A 43 -6.825 43.221 11.140 1.00 26.20 C -ATOM 314 C ASP A 43 -7.737 42.626 12.210 1.00 25.70 C -ATOM 315 O ASP A 43 -8.787 42.081 11.879 1.00 25.64 O -ATOM 316 CB ASP A 43 -5.524 42.401 11.040 1.00 27.86 C -ATOM 317 CG ASP A 43 -5.814 40.952 10.725 1.00 30.64 C -ATOM 318 OD1 ASP A 43 -6.372 40.686 9.642 1.00 37.20 O -ATOM 319 OD2 ASP A 43 -5.576 40.084 11.564 1.00 33.64 O -ATOM 320 N ARG A 44 -7.345 42.729 13.482 1.00 23.76 N -ATOM 321 CA ARG A 44 -8.190 42.297 14.561 1.00 24.05 C -ATOM 322 C ARG A 44 -7.761 42.917 15.906 1.00 24.08 C -ATOM 323 O ARG A 44 -6.608 43.338 16.065 1.00 24.67 O -ATOM 324 CB ARG A 44 -8.171 40.764 14.678 1.00 24.30 C -ATOM 325 CG ARG A 44 -6.835 40.203 15.246 1.00 24.56 C -ATOM 326 CD ARG A 44 -6.770 38.712 15.056 1.00 28.25 C -ATOM 327 NE ARG A 44 -5.527 38.105 15.527 1.00 30.15 N -ATOM 328 CZ ARG A 44 -4.436 37.938 14.774 1.00 30.95 C -ATOM 329 NH1 ARG A 44 -4.413 38.364 13.500 1.00 29.56 N -ATOM 330 NH2 ARG A 44 -3.363 37.358 15.299 1.00 27.85 N -ATOM 331 N PHE A 45 -8.708 42.999 16.839 1.00 23.14 N -ATOM 332 CA PHE A 45 -8.408 43.175 18.265 1.00 23.01 C -ATOM 333 C PHE A 45 -7.891 41.854 18.809 1.00 23.22 C -ATOM 334 O PHE A 45 -8.571 40.821 18.730 1.00 22.43 O -ATOM 335 CB PHE A 45 -9.621 43.696 19.024 1.00 23.17 C -ATOM 336 CG PHE A 45 -9.904 45.174 18.756 1.00 23.12 C -ATOM 337 CD1 PHE A 45 -9.587 46.141 19.696 1.00 22.31 C -ATOM 338 CD2 PHE A 45 -10.456 45.591 17.546 1.00 22.00 C -ATOM 339 CE1 PHE A 45 -9.815 47.525 19.445 1.00 19.37 C -ATOM 340 CE2 PHE A 45 -10.689 46.946 17.299 1.00 24.14 C -ATOM 341 CZ PHE A 45 -10.363 47.920 18.257 1.00 20.26 C -ATOM 342 N ILE A 46 -6.653 41.870 19.303 1.00 22.58 N -ATOM 343 CA ILE A 46 -6.049 40.660 19.811 1.00 22.68 C -ATOM 344 C ILE A 46 -6.900 40.042 20.937 1.00 22.39 C -ATOM 345 O ILE A 46 -7.174 40.697 21.955 1.00 22.85 O -ATOM 346 CB ILE A 46 -4.573 40.901 20.294 1.00 22.60 C -ATOM 347 CG1 ILE A 46 -3.715 41.434 19.130 1.00 21.33 C -ATOM 348 CG2 ILE A 46 -4.021 39.618 20.954 1.00 19.70 C -ATOM 349 CD1 ILE A 46 -2.327 41.989 19.546 1.00 21.68 C -ATOM 350 N GLY A 47 -7.299 38.783 20.761 1.00 21.82 N -ATOM 351 CA GLY A 47 -8.248 38.135 21.701 1.00 20.72 C -ATOM 352 C GLY A 47 -7.794 38.069 23.156 1.00 20.43 C -ATOM 353 O GLY A 47 -8.593 38.229 24.093 1.00 19.67 O -ATOM 354 N THR A 48 -6.499 37.840 23.355 1.00 19.77 N -ATOM 355 CA THR A 48 -5.932 37.739 24.683 1.00 19.66 C -ATOM 356 C THR A 48 -5.613 39.106 25.314 1.00 20.30 C -ATOM 357 O THR A 48 -5.329 39.200 26.512 1.00 20.72 O -ATOM 358 CB THR A 48 -4.619 36.917 24.634 1.00 20.30 C -ATOM 359 OG1 THR A 48 -3.768 37.491 23.644 1.00 20.44 O -ATOM 360 CG2 THR A 48 -4.860 35.453 24.277 1.00 17.40 C -ATOM 361 N GLY A 49 -5.651 40.181 24.535 1.00 20.99 N -ATOM 362 CA GLY A 49 -5.269 41.493 25.078 1.00 20.69 C -ATOM 363 C GLY A 49 -3.758 41.638 25.240 1.00 20.94 C -ATOM 364 O GLY A 49 -3.299 42.624 25.806 1.00 21.56 O -ATOM 365 N MET A 50 -2.983 40.667 24.749 1.00 19.51 N -ATOM 366 CA MET A 50 -1.499 40.721 24.822 1.00 18.69 C -ATOM 367 C MET A 50 -0.883 41.715 23.837 1.00 18.94 C -ATOM 368 O MET A 50 -1.429 41.916 22.738 1.00 19.06 O -ATOM 369 CB MET A 50 -0.898 39.311 24.595 1.00 18.46 C -ATOM 370 CG MET A 50 -1.205 38.359 25.743 1.00 16.28 C -ATOM 371 SD MET A 50 -0.534 36.732 25.499 1.00 20.35 S -ATOM 372 CE MET A 50 1.161 36.996 26.020 1.00 15.70 C -ATOM 373 N ARG A 51 0.266 42.306 24.221 1.00 18.83 N -ATOM 374 CA ARG A 51 0.901 43.405 23.476 1.00 18.83 C -ATOM 375 C ARG A 51 2.255 42.953 22.927 1.00 19.23 C -ATOM 376 O ARG A 51 3.000 42.203 23.600 1.00 18.63 O -ATOM 377 CB ARG A 51 1.111 44.671 24.362 1.00 18.43 C -ATOM 378 CG ARG A 51 -0.162 45.289 24.984 1.00 17.94 C -ATOM 379 CD ARG A 51 0.141 46.584 25.739 1.00 17.07 C -ATOM 380 NE ARG A 51 -1.057 47.096 26.434 1.00 17.53 N -ATOM 381 CZ ARG A 51 -1.381 48.382 26.591 1.00 17.75 C -ATOM 382 NH1 ARG A 51 -0.616 49.350 26.093 1.00 15.93 N -ATOM 383 NH2 ARG A 51 -2.498 48.705 27.248 1.00 17.88 N -ATOM 384 N TYR A 52 2.587 43.425 21.724 1.00 18.81 N -ATOM 385 CA TYR A 52 3.925 43.167 21.179 1.00 20.17 C -ATOM 386 C TYR A 52 4.969 43.754 22.104 1.00 19.88 C -ATOM 387 O TYR A 52 4.909 44.924 22.419 1.00 19.46 O -ATOM 388 CB TYR A 52 4.063 43.715 19.744 1.00 19.61 C -ATOM 389 CG TYR A 52 3.327 42.878 18.720 1.00 21.97 C -ATOM 390 CD1 TYR A 52 4.031 42.070 17.818 1.00 22.85 C -ATOM 391 CD2 TYR A 52 1.918 42.863 18.667 1.00 21.92 C -ATOM 392 CE1 TYR A 52 3.370 41.301 16.883 1.00 21.48 C -ATOM 393 CE2 TYR A 52 1.241 42.079 17.734 1.00 22.65 C -ATOM 394 CZ TYR A 52 1.964 41.293 16.853 1.00 23.39 C -ATOM 395 OH TYR A 52 1.315 40.519 15.914 1.00 21.36 O -ATOM 396 N PRO A 53 5.919 42.920 22.572 1.00 21.29 N -ATOM 397 CA PRO A 53 7.017 43.398 23.428 1.00 21.87 C -ATOM 398 C PRO A 53 8.071 44.269 22.717 1.00 21.70 C -ATOM 399 O PRO A 53 8.819 44.986 23.394 1.00 21.93 O -ATOM 400 CB PRO A 53 7.642 42.106 23.998 1.00 21.72 C -ATOM 401 CG PRO A 53 7.174 40.998 23.100 1.00 22.80 C -ATOM 402 CD PRO A 53 5.885 41.443 22.446 1.00 22.07 C -ATOM 403 N VAL A 54 8.100 44.236 21.382 1.00 20.85 N -ATOM 404 CA VAL A 54 9.007 45.057 20.582 1.00 21.55 C -ATOM 405 C VAL A 54 8.232 45.490 19.356 1.00 20.83 C -ATOM 406 O VAL A 54 7.140 44.972 19.117 1.00 20.05 O -ATOM 407 CB VAL A 54 10.281 44.275 20.107 1.00 22.98 C -ATOM 408 CG1 VAL A 54 11.079 43.719 21.297 1.00 23.11 C -ATOM 409 CG2 VAL A 54 9.884 43.163 19.151 1.00 24.55 C -ATOM 410 N ASN A 55 8.770 46.452 18.602 1.00 19.90 N -ATOM 411 CA ASN A 55 8.127 46.907 17.367 1.00 21.21 C -ATOM 412 C ASN A 55 7.999 45.819 16.329 1.00 20.69 C -ATOM 413 O ASN A 55 8.869 44.984 16.187 1.00 21.68 O -ATOM 414 CB ASN A 55 8.838 48.129 16.748 1.00 20.69 C -ATOM 415 CG ASN A 55 9.109 49.224 17.771 1.00 20.45 C -ATOM 416 OD1 ASN A 55 8.221 50.008 18.123 1.00 17.26 O -ATOM 417 ND2 ASN A 55 10.351 49.292 18.238 1.00 18.77 N -ATOM 418 N TYR A 56 6.903 45.849 15.596 1.00 20.79 N -ATOM 419 CA TYR A 56 6.622 44.831 14.583 1.00 20.61 C -ATOM 420 C TYR A 56 6.243 45.465 13.238 1.00 20.45 C -ATOM 421 O TYR A 56 5.457 46.410 13.177 1.00 19.77 O -ATOM 422 CB TYR A 56 5.479 43.957 15.068 1.00 20.53 C -ATOM 423 CG TYR A 56 5.162 42.754 14.189 1.00 22.99 C -ATOM 424 CD1 TYR A 56 6.112 41.762 13.982 1.00 23.35 C -ATOM 425 CD2 TYR A 56 3.898 42.608 13.593 1.00 22.26 C -ATOM 426 CE1 TYR A 56 5.834 40.653 13.201 1.00 24.86 C -ATOM 427 CE2 TYR A 56 3.606 41.493 12.825 1.00 25.04 C -ATOM 428 CZ TYR A 56 4.585 40.513 12.637 1.00 26.22 C -ATOM 429 OH TYR A 56 4.338 39.402 11.853 1.00 26.67 O -ATOM 430 N GLY A 57 6.814 44.934 12.167 1.00 20.57 N -ATOM 431 CA GLY A 57 6.543 45.425 10.820 1.00 20.64 C -ATOM 432 C GLY A 57 7.020 44.440 9.773 1.00 20.42 C -ATOM 433 O GLY A 57 7.108 43.230 10.030 1.00 20.25 O -ATOM 434 N PHE A 58 7.317 44.956 8.590 1.00 21.49 N -ATOM 435 CA PHE A 58 7.723 44.098 7.462 1.00 22.42 C -ATOM 436 C PHE A 58 8.739 44.803 6.557 1.00 21.95 C -ATOM 437 O PHE A 58 8.846 46.035 6.548 1.00 21.27 O -ATOM 438 CB PHE A 58 6.473 43.668 6.628 1.00 22.41 C -ATOM 439 CG PHE A 58 5.792 44.818 5.923 1.00 25.13 C -ATOM 440 CD1 PHE A 58 6.084 45.105 4.587 1.00 25.77 C -ATOM 441 CD2 PHE A 58 4.881 45.626 6.598 1.00 22.93 C -ATOM 442 CE1 PHE A 58 5.476 46.166 3.936 1.00 24.40 C -ATOM 443 CE2 PHE A 58 4.289 46.717 5.972 1.00 23.86 C -ATOM 444 CZ PHE A 58 4.575 46.987 4.632 1.00 26.77 C -ATOM 445 N ILE A 59 9.456 44.013 5.766 1.00 22.61 N -ATOM 446 CA ILE A 59 10.300 44.571 4.683 1.00 23.33 C -ATOM 447 C ILE A 59 9.523 44.749 3.371 1.00 23.32 C -ATOM 448 O ILE A 59 9.003 43.779 2.827 1.00 24.29 O -ATOM 449 CB ILE A 59 11.557 43.690 4.429 1.00 22.84 C -ATOM 450 CG1 ILE A 59 12.281 43.398 5.748 1.00 22.43 C -ATOM 451 CG2 ILE A 59 12.476 44.360 3.354 1.00 22.00 C -ATOM 452 CD1 ILE A 59 13.474 42.443 5.622 1.00 19.09 C -ATOM 453 N PRO A 60 9.420 45.985 2.872 1.00 24.84 N -ATOM 454 CA PRO A 60 8.675 46.182 1.622 1.00 26.36 C -ATOM 455 C PRO A 60 9.384 45.522 0.421 1.00 27.39 C -ATOM 456 O PRO A 60 10.605 45.317 0.441 1.00 27.93 O -ATOM 457 CB PRO A 60 8.639 47.712 1.456 1.00 25.61 C -ATOM 458 CG PRO A 60 9.839 48.222 2.254 1.00 25.88 C -ATOM 459 CD PRO A 60 9.955 47.257 3.418 1.00 25.38 C -ATOM 460 N GLN A 61 8.609 45.181 -0.600 1.00 28.29 N -ATOM 461 CA GLN A 61 9.159 44.570 -1.809 1.00 29.22 C -ATOM 462 C GLN A 61 9.810 43.208 -1.540 1.00 29.01 C -ATOM 463 O GLN A 61 10.828 42.854 -2.136 1.00 28.95 O -ATOM 464 CB GLN A 61 10.069 45.568 -2.526 1.00 29.21 C -ATOM 465 CG GLN A 61 9.202 46.671 -3.102 1.00 34.78 C -ATOM 466 CD GLN A 61 9.957 47.810 -3.699 1.00 43.57 C -ATOM 467 OE1 GLN A 61 9.386 48.866 -3.940 1.00 47.87 O -ATOM 468 NE2 GLN A 61 11.245 47.619 -3.948 1.00 46.49 N -ATOM 469 N THR A 62 9.218 42.458 -0.616 1.00 28.00 N -ATOM 470 CA THR A 62 9.631 41.093 -0.365 1.00 28.25 C -ATOM 471 C THR A 62 8.383 40.230 -0.370 1.00 29.87 C -ATOM 472 O THR A 62 7.269 40.730 -0.203 1.00 29.15 O -ATOM 473 CB THR A 62 10.397 40.905 0.989 1.00 28.15 C -ATOM 474 OG1 THR A 62 9.545 41.234 2.104 1.00 27.37 O -ATOM 475 CG2 THR A 62 11.679 41.753 1.027 1.00 26.31 C -ATOM 476 N LEU A 63 8.566 38.932 -0.548 1.00 31.16 N -ATOM 477 CA LEU A 63 7.455 38.007 -0.575 1.00 33.88 C -ATOM 478 C LEU A 63 7.944 36.718 0.039 1.00 35.46 C -ATOM 479 O LEU A 63 8.786 36.019 -0.523 1.00 35.30 O -ATOM 480 CB LEU A 63 6.945 37.808 -2.016 1.00 33.87 C -ATOM 481 CG LEU A 63 5.795 36.841 -2.280 1.00 34.60 C -ATOM 482 CD1 LEU A 63 4.662 37.180 -1.363 1.00 36.93 C -ATOM 483 CD2 LEU A 63 5.340 36.969 -3.724 1.00 36.15 C -ATOM 484 N SER A 64 7.437 36.436 1.230 1.00 38.38 N -ATOM 485 CA SER A 64 7.886 35.307 2.023 1.00 41.11 C -ATOM 486 C SER A 64 7.191 34.036 1.577 1.00 43.10 C -ATOM 487 O SER A 64 6.349 34.064 0.671 1.00 42.92 O -ATOM 488 CB SER A 64 7.564 35.543 3.500 1.00 41.35 C -ATOM 489 OG SER A 64 8.363 34.696 4.315 1.00 42.71 O -ATOM 490 N GLY A 65 7.537 32.927 2.229 1.00 45.14 N -ATOM 491 CA GLY A 65 6.892 31.638 1.968 1.00 47.76 C -ATOM 492 C GLY A 65 5.362 31.636 2.005 1.00 49.24 C -ATOM 493 O GLY A 65 4.723 30.859 1.293 1.00 50.21 O -ATOM 494 N ASP A 66 4.753 32.482 2.832 1.00 50.27 N -ATOM 495 CA ASP A 66 3.284 32.510 2.911 1.00 50.78 C -ATOM 496 C ASP A 66 2.609 33.496 1.940 1.00 50.21 C -ATOM 497 O ASP A 66 1.385 33.600 1.897 1.00 50.77 O -ATOM 498 CB ASP A 66 2.820 32.798 4.342 1.00 51.29 C -ATOM 499 CG ASP A 66 3.509 34.005 4.947 1.00 54.17 C -ATOM 500 OD1 ASP A 66 3.722 35.014 4.219 1.00 55.27 O -ATOM 501 OD2 ASP A 66 3.843 33.936 6.161 1.00 57.76 O -ATOM 502 N GLY A 67 3.379 34.233 1.160 1.00 48.96 N -ATOM 503 CA GLY A 67 2.739 35.181 0.272 1.00 47.16 C -ATOM 504 C GLY A 67 2.604 36.550 0.903 1.00 45.61 C -ATOM 505 O GLY A 67 2.093 37.467 0.266 1.00 46.42 O -ATOM 506 N ASP A 68 3.068 36.690 2.147 1.00 44.01 N -ATOM 507 CA ASP A 68 3.176 37.990 2.828 1.00 41.68 C -ATOM 508 C ASP A 68 4.634 38.442 2.804 1.00 38.69 C -ATOM 509 O ASP A 68 5.530 37.609 2.702 1.00 38.18 O -ATOM 510 CB ASP A 68 2.772 37.862 4.299 1.00 43.06 C -ATOM 511 CG ASP A 68 1.260 37.693 4.501 1.00 47.11 C -ATOM 512 OD1 ASP A 68 0.458 38.106 3.618 1.00 50.50 O -ATOM 513 OD2 ASP A 68 0.885 37.144 5.569 1.00 51.66 O -ATOM 514 N PRO A 69 4.880 39.755 2.945 1.00 35.51 N -ATOM 515 CA PRO A 69 6.253 40.252 3.039 1.00 33.20 C -ATOM 516 C PRO A 69 7.007 39.648 4.217 1.00 31.00 C -ATOM 517 O PRO A 69 6.388 39.081 5.103 1.00 30.18 O -ATOM 518 CB PRO A 69 6.082 41.767 3.260 1.00 33.04 C -ATOM 519 CG PRO A 69 4.739 42.103 2.734 1.00 35.64 C -ATOM 520 CD PRO A 69 3.880 40.839 2.971 1.00 35.76 C -ATOM 521 N VAL A 70 8.336 39.778 4.232 1.00 29.44 N -ATOM 522 CA VAL A 70 9.151 39.250 5.348 1.00 27.95 C -ATOM 523 C VAL A 70 8.837 40.047 6.625 1.00 26.77 C -ATOM 524 O VAL A 70 8.915 41.270 6.619 1.00 26.46 O -ATOM 525 CB VAL A 70 10.703 39.275 5.026 1.00 27.88 C -ATOM 526 CG1 VAL A 70 11.514 38.958 6.258 1.00 27.39 C -ATOM 527 CG2 VAL A 70 11.056 38.280 3.898 1.00 27.44 C -ATOM 528 N ASP A 71 8.452 39.351 7.693 1.00 26.51 N -ATOM 529 CA ASP A 71 8.153 39.968 9.014 1.00 26.25 C -ATOM 530 C ASP A 71 9.381 40.260 9.866 1.00 25.56 C -ATOM 531 O ASP A 71 10.322 39.450 9.926 1.00 25.69 O -ATOM 532 CB ASP A 71 7.284 39.034 9.838 1.00 26.37 C -ATOM 533 CG ASP A 71 5.942 38.790 9.227 1.00 28.24 C -ATOM 534 OD1 ASP A 71 5.331 39.745 8.677 1.00 30.97 O -ATOM 535 OD2 ASP A 71 5.496 37.624 9.306 1.00 28.38 O -ATOM 536 N VAL A 72 9.362 41.410 10.542 1.00 24.69 N -ATOM 537 CA VAL A 72 10.480 41.870 11.382 1.00 22.19 C -ATOM 538 C VAL A 72 10.034 42.475 12.735 1.00 22.12 C -ATOM 539 O VAL A 72 9.148 43.330 12.811 1.00 21.39 O -ATOM 540 CB VAL A 72 11.395 42.879 10.629 1.00 22.97 C -ATOM 541 CG1 VAL A 72 12.704 43.137 11.390 1.00 20.10 C -ATOM 542 CG2 VAL A 72 11.667 42.402 9.171 1.00 21.68 C -ATOM 543 N LEU A 73 10.666 41.984 13.798 1.00 21.86 N -ATOM 544 CA LEU A 73 10.673 42.593 15.127 1.00 21.24 C -ATOM 545 C LEU A 73 11.900 43.511 15.274 1.00 21.59 C -ATOM 546 O LEU A 73 13.030 43.037 15.180 1.00 22.50 O -ATOM 547 CB LEU A 73 10.739 41.468 16.172 1.00 21.37 C -ATOM 548 CG LEU A 73 9.561 40.490 16.014 1.00 21.82 C -ATOM 549 CD1 LEU A 73 9.902 39.045 16.446 1.00 23.52 C -ATOM 550 CD2 LEU A 73 8.331 41.011 16.770 1.00 20.84 C -ATOM 551 N VAL A 74 11.681 44.815 15.494 1.00 20.95 N -ATOM 552 CA VAL A 74 12.752 45.796 15.684 1.00 19.54 C -ATOM 553 C VAL A 74 12.771 46.277 17.140 1.00 20.67 C -ATOM 554 O VAL A 74 11.768 46.843 17.646 1.00 19.81 O -ATOM 555 CB VAL A 74 12.558 47.027 14.796 1.00 19.11 C -ATOM 556 CG1 VAL A 74 13.790 47.916 14.808 1.00 16.39 C -ATOM 557 CG2 VAL A 74 12.228 46.592 13.359 1.00 19.06 C -ATOM 558 N ILE A 75 13.897 46.030 17.812 1.00 20.76 N -ATOM 559 CA ILE A 75 14.131 46.466 19.213 1.00 21.77 C -ATOM 560 C ILE A 75 14.639 47.928 19.210 1.00 22.17 C -ATOM 561 O ILE A 75 15.604 48.245 18.487 1.00 22.78 O -ATOM 562 CB ILE A 75 15.171 45.535 19.898 1.00 21.89 C -ATOM 563 CG1 ILE A 75 14.703 44.087 19.786 1.00 21.31 C -ATOM 564 CG2 ILE A 75 15.461 45.946 21.348 1.00 21.98 C -ATOM 565 CD1 ILE A 75 15.763 43.077 20.206 1.00 21.97 C -ATOM 566 N THR A 76 13.967 48.806 19.964 1.00 21.05 N -ATOM 567 CA THR A 76 14.385 50.220 20.093 1.00 20.95 C -ATOM 568 C THR A 76 14.241 50.718 21.543 1.00 20.55 C -ATOM 569 O THR A 76 13.450 50.161 22.299 1.00 19.88 O -ATOM 570 CB THR A 76 13.551 51.151 19.153 1.00 20.86 C -ATOM 571 OG1 THR A 76 12.167 51.040 19.496 1.00 19.99 O -ATOM 572 CG2 THR A 76 13.745 50.762 17.658 1.00 18.48 C -ATOM 573 N PRO A 77 14.992 51.770 21.934 1.00 20.91 N -ATOM 574 CA PRO A 77 14.763 52.260 23.309 1.00 21.70 C -ATOM 575 C PRO A 77 13.382 52.961 23.583 1.00 21.66 C -ATOM 576 O PRO A 77 12.953 53.016 24.743 1.00 21.57 O -ATOM 577 CB PRO A 77 15.953 53.209 23.563 1.00 21.31 C -ATOM 578 CG PRO A 77 16.481 53.561 22.213 1.00 21.76 C -ATOM 579 CD PRO A 77 16.165 52.408 21.295 1.00 20.66 C -ATOM 580 N PHE A 78 12.709 53.456 22.545 1.00 20.64 N -ATOM 581 CA PHE A 78 11.360 54.051 22.662 1.00 21.02 C -ATOM 582 C PHE A 78 10.529 53.502 21.508 1.00 20.26 C -ATOM 583 O PHE A 78 11.074 53.303 20.404 1.00 20.09 O -ATOM 584 CB PHE A 78 11.409 55.603 22.539 1.00 20.99 C -ATOM 585 CG PHE A 78 12.129 56.296 23.695 1.00 22.97 C -ATOM 586 CD1 PHE A 78 11.482 56.496 24.931 1.00 22.93 C -ATOM 587 CD2 PHE A 78 13.446 56.731 23.549 1.00 20.66 C -ATOM 588 CE1 PHE A 78 12.148 57.089 25.992 1.00 23.48 C -ATOM 589 CE2 PHE A 78 14.113 57.329 24.597 1.00 21.65 C -ATOM 590 CZ PHE A 78 13.472 57.507 25.823 1.00 23.50 C -ATOM 591 N PRO A 79 9.201 53.295 21.718 1.00 20.67 N -ATOM 592 CA PRO A 79 8.431 52.730 20.586 1.00 19.72 C -ATOM 593 C PRO A 79 8.502 53.606 19.329 1.00 19.61 C -ATOM 594 O PRO A 79 8.687 54.817 19.437 1.00 18.61 O -ATOM 595 CB PRO A 79 6.993 52.618 21.137 1.00 20.21 C -ATOM 596 CG PRO A 79 7.184 52.577 22.674 1.00 21.91 C -ATOM 597 CD PRO A 79 8.355 53.522 22.918 1.00 19.80 C -ATOM 598 N LEU A 80 8.406 52.986 18.147 1.00 19.41 N -ATOM 599 CA LEU A 80 8.376 53.710 16.869 1.00 19.62 C -ATOM 600 C LEU A 80 6.920 53.965 16.446 1.00 20.50 C -ATOM 601 O LEU A 80 5.997 53.210 16.777 1.00 19.42 O -ATOM 602 CB LEU A 80 9.054 52.878 15.740 1.00 19.52 C -ATOM 603 CG LEU A 80 10.550 52.569 15.948 1.00 19.77 C -ATOM 604 CD1 LEU A 80 11.033 51.619 14.875 1.00 18.38 C -ATOM 605 CD2 LEU A 80 11.365 53.875 15.950 1.00 18.69 C -ATOM 606 N LEU A 81 6.753 55.018 15.663 1.00 21.45 N -ATOM 607 CA LEU A 81 5.481 55.415 15.076 1.00 21.99 C -ATOM 608 C LEU A 81 4.960 54.399 14.062 1.00 21.60 C -ATOM 609 O LEU A 81 5.681 54.045 13.128 1.00 21.18 O -ATOM 610 CB LEU A 81 5.765 56.717 14.338 1.00 22.29 C -ATOM 611 CG LEU A 81 4.838 57.896 14.175 1.00 28.01 C -ATOM 612 CD1 LEU A 81 3.889 58.076 15.398 1.00 30.54 C -ATOM 613 CD2 LEU A 81 5.729 59.117 13.976 1.00 30.14 C -ATOM 614 N ALA A 82 3.701 53.961 14.200 1.00 20.50 N -ATOM 615 CA ALA A 82 3.095 53.083 13.205 1.00 20.23 C -ATOM 616 C ALA A 82 3.032 53.805 11.851 1.00 20.71 C -ATOM 617 O ALA A 82 2.606 54.969 11.775 1.00 19.92 O -ATOM 618 CB ALA A 82 1.685 52.621 13.648 1.00 19.13 C -ATOM 619 N GLY A 83 3.473 53.115 10.797 1.00 21.09 N -ATOM 620 CA GLY A 83 3.454 53.652 9.450 1.00 21.60 C -ATOM 621 C GLY A 83 4.756 54.354 9.070 1.00 22.41 C -ATOM 622 O GLY A 83 4.908 54.785 7.922 1.00 22.78 O -ATOM 623 N SER A 84 5.675 54.500 10.026 1.00 21.49 N -ATOM 624 CA SER A 84 7.003 55.049 9.743 1.00 22.62 C -ATOM 625 C SER A 84 7.955 53.963 9.176 1.00 23.06 C -ATOM 626 O SER A 84 7.665 52.766 9.271 1.00 23.25 O -ATOM 627 CB SER A 84 7.612 55.745 10.986 1.00 21.55 C -ATOM 628 OG SER A 84 7.949 54.826 12.039 1.00 21.85 O -ATOM 629 N VAL A 85 9.091 54.414 8.626 1.00 23.53 N -ATOM 630 CA VAL A 85 10.136 53.570 8.060 1.00 22.93 C -ATOM 631 C VAL A 85 11.427 53.725 8.856 1.00 22.89 C -ATOM 632 O VAL A 85 11.826 54.860 9.204 1.00 23.40 O -ATOM 633 CB VAL A 85 10.436 53.956 6.572 1.00 23.72 C -ATOM 634 CG1 VAL A 85 11.236 52.843 5.886 1.00 23.82 C -ATOM 635 CG2 VAL A 85 9.154 54.114 5.810 1.00 23.40 C -ATOM 636 N VAL A 86 12.073 52.594 9.143 1.00 21.59 N -ATOM 637 CA VAL A 86 13.346 52.564 9.868 1.00 21.61 C -ATOM 638 C VAL A 86 14.397 51.698 9.102 1.00 22.02 C -ATOM 639 O VAL A 86 14.128 50.570 8.703 1.00 21.87 O -ATOM 640 CB VAL A 86 13.192 52.095 11.360 1.00 21.44 C -ATOM 641 CG1 VAL A 86 12.660 50.635 11.465 1.00 20.11 C -ATOM 642 CG2 VAL A 86 14.521 52.237 12.127 1.00 19.16 C -ATOM 643 N ARG A 87 15.561 52.278 8.859 1.00 21.94 N -ATOM 644 CA ARG A 87 16.701 51.555 8.303 1.00 22.74 C -ATOM 645 C ARG A 87 17.227 50.629 9.390 1.00 22.19 C -ATOM 646 O ARG A 87 17.477 51.113 10.489 1.00 22.02 O -ATOM 647 CB ARG A 87 17.783 52.582 7.935 1.00 23.60 C -ATOM 648 CG ARG A 87 18.974 51.991 7.197 1.00 23.36 C -ATOM 649 CD ARG A 87 19.981 53.075 6.916 1.00 25.35 C -ATOM 650 NE ARG A 87 21.014 52.623 5.994 1.00 26.55 N -ATOM 651 CZ ARG A 87 22.042 53.356 5.581 1.00 30.00 C -ATOM 652 NH1 ARG A 87 22.199 54.589 6.009 1.00 30.00 N -ATOM 653 NH2 ARG A 87 22.922 52.846 4.730 1.00 29.59 N -ATOM 654 N ALA A 88 17.362 49.318 9.097 1.00 21.61 N -ATOM 655 CA ALA A 88 17.679 48.293 10.097 1.00 20.95 C -ATOM 656 C ALA A 88 18.751 47.274 9.647 1.00 21.61 C -ATOM 657 O ALA A 88 19.144 47.220 8.463 1.00 21.00 O -ATOM 658 CB ALA A 88 16.418 47.553 10.513 1.00 21.45 C -ATOM 659 N ARG A 89 19.239 46.501 10.616 1.00 21.20 N -ATOM 660 CA ARG A 89 20.154 45.376 10.373 1.00 21.57 C -ATOM 661 C ARG A 89 19.695 44.194 11.214 1.00 21.96 C -ATOM 662 O ARG A 89 19.012 44.373 12.257 1.00 21.50 O -ATOM 663 CB ARG A 89 21.613 45.764 10.731 1.00 20.98 C -ATOM 664 CG ARG A 89 21.869 45.980 12.223 1.00 19.77 C -ATOM 665 CD ARG A 89 23.319 46.440 12.496 1.00 21.57 C -ATOM 666 NE ARG A 89 23.500 46.936 13.863 1.00 20.57 N -ATOM 667 CZ ARG A 89 23.630 46.151 14.929 1.00 21.84 C -ATOM 668 NH1 ARG A 89 23.633 44.840 14.798 1.00 19.04 N -ATOM 669 NH2 ARG A 89 23.774 46.671 16.132 1.00 24.53 N -ATOM 670 N ALA A 90 20.093 42.985 10.816 1.00 22.44 N -ATOM 671 CA ALA A 90 19.509 41.774 11.382 1.00 23.02 C -ATOM 672 C ALA A 90 20.309 41.265 12.545 1.00 23.69 C -ATOM 673 O ALA A 90 21.524 41.444 12.591 1.00 24.80 O -ATOM 674 CB ALA A 90 19.382 40.685 10.333 1.00 23.51 C -ATOM 675 N LEU A 91 19.625 40.629 13.495 1.00 24.22 N -ATOM 676 CA LEU A 91 20.296 39.970 14.629 1.00 24.39 C -ATOM 677 C LEU A 91 20.118 38.460 14.517 1.00 24.55 C -ATOM 678 O LEU A 91 20.957 37.687 15.007 1.00 25.20 O -ATOM 679 CB LEU A 91 19.727 40.438 15.986 1.00 23.48 C -ATOM 680 CG LEU A 91 19.877 41.904 16.414 1.00 22.92 C -ATOM 681 CD1 LEU A 91 19.353 42.033 17.849 1.00 22.77 C -ATOM 682 CD2 LEU A 91 21.316 42.376 16.328 1.00 23.57 C -ATOM 683 N GLY A 92 19.021 38.032 13.890 1.00 25.11 N -ATOM 684 CA GLY A 92 18.676 36.607 13.886 1.00 24.76 C -ATOM 685 C GLY A 92 17.206 36.405 13.589 1.00 25.72 C -ATOM 686 O GLY A 92 16.566 37.253 12.962 1.00 24.40 O -ATOM 687 N MET A 93 16.646 35.283 14.026 1.00 26.58 N -ATOM 688 CA MET A 93 15.233 35.027 13.722 1.00 28.72 C -ATOM 689 C MET A 93 14.593 34.024 14.653 1.00 28.92 C -ATOM 690 O MET A 93 15.277 33.173 15.231 1.00 29.48 O -ATOM 691 CB MET A 93 15.019 34.623 12.238 1.00 29.18 C -ATOM 692 CG MET A 93 15.660 33.304 11.809 1.00 33.11 C -ATOM 693 SD MET A 93 15.636 33.076 9.990 1.00 40.50 S -ATOM 694 CE MET A 93 13.962 32.560 9.708 1.00 37.67 C -ATOM 695 N LEU A 94 13.278 34.144 14.810 1.00 29.01 N -ATOM 696 CA LEU A 94 12.506 33.156 15.553 1.00 30.00 C -ATOM 697 C LEU A 94 11.801 32.247 14.556 1.00 30.90 C -ATOM 698 O LEU A 94 11.070 32.735 13.699 1.00 30.26 O -ATOM 699 CB LEU A 94 11.484 33.838 16.460 1.00 29.19 C -ATOM 700 CG LEU A 94 10.751 32.998 17.514 1.00 30.25 C -ATOM 701 CD1 LEU A 94 11.717 32.305 18.452 1.00 29.45 C -ATOM 702 CD2 LEU A 94 9.800 33.894 18.320 1.00 28.35 C -ATOM 703 N LYS A 95 12.034 30.934 14.648 1.00 32.44 N -ATOM 704 CA LYS A 95 11.368 29.980 13.755 1.00 34.21 C -ATOM 705 C LYS A 95 10.137 29.384 14.420 1.00 34.50 C -ATOM 706 O LYS A 95 10.183 28.971 15.569 1.00 33.94 O -ATOM 707 CB LYS A 95 12.338 28.865 13.332 1.00 35.22 C -ATOM 708 CG LYS A 95 13.401 29.320 12.297 1.00 38.73 C -ATOM 709 CD LYS A 95 14.737 28.595 12.495 1.00 44.84 C -ATOM 710 CE LYS A 95 14.583 27.069 12.322 1.00 48.49 C -ATOM 711 NZ LYS A 95 15.502 26.237 13.209 1.00 50.26 N -ATOM 712 N MET A 96 9.029 29.351 13.698 1.00 35.87 N -ATOM 713 CA MET A 96 7.770 28.871 14.259 1.00 37.62 C -ATOM 714 C MET A 96 6.990 28.206 13.144 1.00 38.88 C -ATOM 715 O MET A 96 7.303 28.406 11.969 1.00 38.99 O -ATOM 716 CB MET A 96 6.915 30.046 14.783 1.00 36.87 C -ATOM 717 CG MET A 96 7.445 30.766 16.014 1.00 36.05 C -ATOM 718 SD MET A 96 6.661 32.397 16.227 1.00 32.47 S -ATOM 719 CE MET A 96 7.289 33.359 14.839 1.00 33.43 C -ATOM 720 N THR A 97 5.953 27.458 13.519 1.00 40.89 N -ATOM 721 CA THR A 97 4.894 27.078 12.584 1.00 43.05 C -ATOM 722 C THR A 97 3.560 27.461 13.229 1.00 43.77 C -ATOM 723 O THR A 97 3.380 27.280 14.438 1.00 44.35 O -ATOM 724 CB THR A 97 4.920 25.547 12.208 1.00 43.28 C -ATOM 725 OG1 THR A 97 5.127 24.765 13.384 1.00 45.70 O -ATOM 726 CG2 THR A 97 6.061 25.231 11.257 1.00 43.69 C -ATOM 727 N ASP A 98 2.644 28.028 12.446 1.00 44.41 N -ATOM 728 CA ASP A 98 1.321 28.342 12.967 1.00 45.30 C -ATOM 729 C ASP A 98 0.228 27.653 12.151 1.00 46.22 C -ATOM 730 O ASP A 98 0.517 26.775 11.331 1.00 46.61 O -ATOM 731 CB ASP A 98 1.088 29.858 13.021 1.00 45.20 C -ATOM 732 CG ASP A 98 0.949 30.472 11.652 1.00 45.80 C -ATOM 733 OD1 ASP A 98 1.027 29.722 10.662 1.00 45.37 O -ATOM 734 OD2 ASP A 98 0.764 31.704 11.562 1.00 44.84 O -ATOM 735 N GLU A 99 -1.028 28.042 12.377 1.00 46.47 N -ATOM 736 CA GLU A 99 -2.141 27.402 11.687 1.00 46.80 C -ATOM 737 C GLU A 99 -2.006 27.467 10.147 1.00 47.27 C -ATOM 738 O GLU A 99 -2.538 26.623 9.442 1.00 47.92 O -ATOM 739 CB GLU A 99 -3.483 27.973 12.161 1.00 45.98 C -ATOM 740 CG GLU A 99 -3.807 29.333 11.593 1.00 44.99 C -ATOM 741 CD GLU A 99 -3.196 30.497 12.389 1.00 42.89 C -ATOM 742 OE1 GLU A 99 -3.428 31.661 11.987 1.00 42.58 O -ATOM 743 OE2 GLU A 99 -2.503 30.248 13.405 1.00 41.44 O -ATOM 744 N SER A 100 -1.279 28.448 9.624 1.00 47.51 N -ATOM 745 CA SER A 100 -1.091 28.565 8.177 1.00 47.27 C -ATOM 746 C SER A 100 0.262 28.046 7.694 1.00 47.08 C -ATOM 747 O SER A 100 0.694 28.388 6.592 1.00 47.42 O -ATOM 748 CB SER A 100 -1.245 30.025 7.730 1.00 47.15 C -ATOM 749 OG SER A 100 -2.525 30.535 8.068 1.00 48.79 O -ATOM 750 N GLY A 101 0.939 27.237 8.507 1.00 46.73 N -ATOM 751 CA GLY A 101 2.222 26.653 8.110 1.00 45.72 C -ATOM 752 C GLY A 101 3.430 27.411 8.650 1.00 45.34 C -ATOM 753 O GLY A 101 3.320 28.159 9.633 1.00 45.08 O -ATOM 754 N VAL A 102 4.585 27.222 8.008 1.00 44.18 N -ATOM 755 CA VAL A 102 5.851 27.802 8.476 1.00 43.13 C -ATOM 756 C VAL A 102 5.795 29.319 8.668 1.00 42.11 C -ATOM 757 O VAL A 102 5.204 30.039 7.858 1.00 41.60 O -ATOM 758 CB VAL A 102 7.015 27.444 7.524 1.00 43.66 C -ATOM 759 CG1 VAL A 102 8.164 28.428 7.684 1.00 43.30 C -ATOM 760 CG2 VAL A 102 7.488 25.988 7.764 1.00 43.78 C -ATOM 761 N ASP A 103 6.415 29.804 9.744 1.00 41.05 N -ATOM 762 CA ASP A 103 6.375 31.242 10.062 1.00 39.44 C -ATOM 763 C ASP A 103 7.649 31.697 10.761 1.00 37.83 C -ATOM 764 O ASP A 103 7.784 31.562 11.973 1.00 38.58 O -ATOM 765 CB ASP A 103 5.182 31.541 10.962 1.00 39.54 C -ATOM 766 CG ASP A 103 4.926 33.029 11.126 1.00 40.16 C -ATOM 767 OD1 ASP A 103 5.544 33.843 10.396 1.00 42.27 O -ATOM 768 OD2 ASP A 103 4.081 33.379 11.977 1.00 38.14 O -ATOM 769 N ALA A 104 8.591 32.226 9.995 1.00 35.52 N -ATOM 770 CA ALA A 104 9.799 32.789 10.562 1.00 32.80 C -ATOM 771 C ALA A 104 9.611 34.300 10.727 1.00 30.91 C -ATOM 772 O ALA A 104 9.037 34.959 9.857 1.00 30.17 O -ATOM 773 CB ALA A 104 10.955 32.514 9.651 1.00 33.11 C -ATOM 774 N LYS A 105 10.079 34.838 11.847 1.00 29.57 N -ATOM 775 CA LYS A 105 10.147 36.293 12.036 1.00 28.05 C -ATOM 776 C LYS A 105 11.562 36.720 12.391 1.00 27.06 C -ATOM 777 O LYS A 105 12.174 36.150 13.289 1.00 27.14 O -ATOM 778 CB LYS A 105 9.142 36.750 13.090 1.00 27.30 C -ATOM 779 CG LYS A 105 7.712 36.235 12.749 1.00 27.03 C -ATOM 780 CD LYS A 105 6.645 37.016 13.447 1.00 26.83 C -ATOM 781 CE LYS A 105 5.287 36.300 13.367 1.00 24.94 C -ATOM 782 NZ LYS A 105 4.698 36.387 11.996 1.00 23.03 N -ATOM 783 N LEU A 106 12.058 37.734 11.691 1.00 25.68 N -ATOM 784 CA LEU A 106 13.374 38.275 11.962 1.00 25.87 C -ATOM 785 C LEU A 106 13.354 39.143 13.222 1.00 25.22 C -ATOM 786 O LEU A 106 12.314 39.719 13.598 1.00 24.89 O -ATOM 787 CB LEU A 106 13.857 39.118 10.784 1.00 25.38 C -ATOM 788 CG LEU A 106 14.443 38.394 9.564 1.00 27.94 C -ATOM 789 CD1 LEU A 106 13.727 37.094 9.184 1.00 27.95 C -ATOM 790 CD2 LEU A 106 14.567 39.332 8.388 1.00 26.61 C -ATOM 791 N VAL A 107 14.523 39.257 13.838 1.00 23.51 N -ATOM 792 CA VAL A 107 14.716 40.131 14.964 1.00 22.73 C -ATOM 793 C VAL A 107 15.811 41.090 14.512 1.00 22.68 C -ATOM 794 O VAL A 107 16.854 40.661 14.003 1.00 22.46 O -ATOM 795 CB VAL A 107 15.080 39.338 16.238 1.00 22.27 C -ATOM 796 CG1 VAL A 107 15.343 40.270 17.373 1.00 22.46 C -ATOM 797 CG2 VAL A 107 13.939 38.318 16.594 1.00 23.92 C -ATOM 798 N ALA A 108 15.553 42.392 14.645 1.00 21.45 N -ATOM 799 CA ALA A 108 16.439 43.391 14.095 1.00 20.74 C -ATOM 800 C ALA A 108 16.607 44.559 15.068 1.00 21.23 C -ATOM 801 O ALA A 108 15.871 44.634 16.070 1.00 21.11 O -ATOM 802 CB ALA A 108 15.903 43.883 12.721 1.00 19.22 C -ATOM 803 N VAL A 109 17.600 45.423 14.790 1.00 20.09 N -ATOM 804 CA VAL A 109 17.739 46.729 15.426 1.00 21.46 C -ATOM 805 C VAL A 109 17.973 47.762 14.319 1.00 21.87 C -ATOM 806 O VAL A 109 18.314 47.381 13.202 1.00 21.72 O -ATOM 807 CB VAL A 109 18.928 46.784 16.409 1.00 20.91 C -ATOM 808 CG1 VAL A 109 18.614 46.011 17.652 1.00 20.05 C -ATOM 809 CG2 VAL A 109 20.208 46.218 15.733 1.00 22.26 C -ATOM 810 N PRO A 110 17.804 49.068 14.626 1.00 22.19 N -ATOM 811 CA PRO A 110 18.094 50.056 13.594 1.00 22.34 C -ATOM 812 C PRO A 110 19.597 50.067 13.216 1.00 23.74 C -ATOM 813 O PRO A 110 20.435 49.546 13.963 1.00 23.41 O -ATOM 814 CB PRO A 110 17.717 51.405 14.280 1.00 22.83 C -ATOM 815 CG PRO A 110 16.791 51.058 15.399 1.00 21.11 C -ATOM 816 CD PRO A 110 17.289 49.695 15.870 1.00 21.07 C -ATOM 817 N HIS A 111 19.905 50.663 12.062 1.00 24.43 N -ATOM 818 CA HIS A 111 21.269 51.039 11.680 1.00 25.10 C -ATOM 819 C HIS A 111 21.948 51.765 12.839 1.00 25.61 C -ATOM 820 O HIS A 111 21.322 52.588 13.518 1.00 26.10 O -ATOM 821 CB HIS A 111 21.182 51.975 10.450 1.00 24.91 C -ATOM 822 CG HIS A 111 22.509 52.407 9.893 1.00 26.79 C -ATOM 823 ND1 HIS A 111 23.070 51.820 8.770 1.00 29.91 N -ATOM 824 CD2 HIS A 111 23.393 53.348 10.305 1.00 23.68 C -ATOM 825 CE1 HIS A 111 24.235 52.393 8.514 1.00 26.42 C -ATOM 826 NE2 HIS A 111 24.442 53.336 9.416 1.00 26.73 N -ATOM 827 N ASP A 112 23.234 51.504 13.051 1.00 25.54 N -ATOM 828 CA ASP A 112 23.979 52.129 14.147 1.00 25.57 C -ATOM 829 C ASP A 112 23.942 53.667 14.222 1.00 25.64 C -ATOM 830 O ASP A 112 24.009 54.219 15.303 1.00 25.60 O -ATOM 831 CB ASP A 112 25.433 51.655 14.148 1.00 26.15 C -ATOM 832 CG ASP A 112 25.577 50.191 14.586 1.00 25.67 C -ATOM 833 OD1 ASP A 112 24.592 49.558 15.018 1.00 29.82 O -ATOM 834 OD2 ASP A 112 26.687 49.675 14.528 1.00 26.95 O -ATOM 835 N LYS A 113 23.866 54.355 13.095 1.00 25.60 N -ATOM 836 CA LYS A 113 23.786 55.819 13.100 1.00 26.31 C -ATOM 837 C LYS A 113 22.358 56.299 13.405 1.00 26.01 C -ATOM 838 O LYS A 113 22.150 57.398 13.891 1.00 27.30 O -ATOM 839 CB LYS A 113 24.288 56.390 11.768 1.00 26.96 C -ATOM 840 N VAL A 114 21.370 55.453 13.158 1.00 25.69 N -ATOM 841 CA VAL A 114 19.998 55.764 13.562 1.00 24.61 C -ATOM 842 C VAL A 114 19.806 55.525 15.065 1.00 25.10 C -ATOM 843 O VAL A 114 19.249 56.379 15.773 1.00 24.38 O -ATOM 844 CB VAL A 114 19.001 54.950 12.751 1.00 25.32 C -ATOM 845 CG1 VAL A 114 17.528 55.198 13.246 1.00 23.89 C -ATOM 846 CG2 VAL A 114 19.202 55.234 11.260 1.00 22.62 C -ATOM 847 N CYS A 115 20.318 54.395 15.563 1.00 24.30 N -ATOM 848 CA CYS A 115 20.191 54.054 16.978 1.00 24.45 C -ATOM 849 C CYS A 115 21.523 53.611 17.614 1.00 25.28 C -ATOM 850 O CYS A 115 21.821 52.409 17.705 1.00 25.35 O -ATOM 851 CB CYS A 115 19.111 52.977 17.168 1.00 24.20 C -ATOM 852 SG CYS A 115 18.644 52.733 18.908 1.00 23.28 S -ATOM 853 N PRO A 116 22.343 54.583 18.036 1.00 25.64 N -ATOM 854 CA PRO A 116 23.601 54.246 18.715 1.00 25.83 C -ATOM 855 C PRO A 116 23.382 53.386 19.946 1.00 26.76 C -ATOM 856 O PRO A 116 24.274 52.606 20.303 1.00 27.28 O -ATOM 857 CB PRO A 116 24.150 55.613 19.142 1.00 25.73 C -ATOM 858 CG PRO A 116 23.576 56.573 18.005 1.00 26.37 C -ATOM 859 CD PRO A 116 22.177 56.038 17.826 1.00 24.59 C -ATOM 860 N MET A 117 22.213 53.510 20.569 1.00 25.92 N -ATOM 861 CA MET A 117 21.880 52.798 21.806 1.00 25.99 C -ATOM 862 C MET A 117 21.872 51.286 21.630 1.00 26.46 C -ATOM 863 O MET A 117 22.001 50.553 22.613 1.00 25.60 O -ATOM 864 CB MET A 117 20.492 53.211 22.307 1.00 25.61 C -ATOM 865 CG MET A 117 20.329 54.735 22.551 1.00 25.77 C -ATOM 866 SD MET A 117 19.862 55.666 21.073 1.00 23.51 S -ATOM 867 CE MET A 117 20.351 57.314 21.549 1.00 23.67 C -ATOM 868 N THR A 118 21.643 50.816 20.396 1.00 26.44 N -ATOM 869 CA THR A 118 21.572 49.368 20.159 1.00 26.45 C -ATOM 870 C THR A 118 22.833 48.825 19.435 1.00 26.58 C -ATOM 871 O THR A 118 22.882 47.643 19.071 1.00 25.87 O -ATOM 872 CB THR A 118 20.255 48.931 19.388 1.00 26.23 C -ATOM 873 OG1 THR A 118 20.061 49.752 18.255 1.00 25.67 O -ATOM 874 CG2 THR A 118 18.975 49.004 20.277 1.00 24.93 C -ATOM 875 N ALA A 119 23.848 49.673 19.264 1.00 26.81 N -ATOM 876 CA ALA A 119 25.069 49.285 18.509 1.00 27.89 C -ATOM 877 C ALA A 119 25.785 48.057 19.057 1.00 28.60 C -ATOM 878 O ALA A 119 26.365 47.295 18.299 1.00 28.79 O -ATOM 879 CB ALA A 119 26.024 50.442 18.375 1.00 27.47 C -ATOM 880 N ASN A 120 25.712 47.837 20.364 1.00 30.19 N -ATOM 881 CA ASN A 120 26.394 46.697 20.978 1.00 31.83 C -ATOM 882 C ASN A 120 25.633 45.400 20.871 1.00 31.62 C -ATOM 883 O ASN A 120 26.124 44.389 21.335 1.00 30.93 O -ATOM 884 CB ASN A 120 26.733 46.965 22.447 1.00 33.05 C -ATOM 885 CG ASN A 120 27.805 48.055 22.605 1.00 38.99 C -ATOM 886 OD1 ASN A 120 28.787 48.097 21.842 1.00 44.64 O -ATOM 887 ND2 ASN A 120 27.610 48.953 23.578 1.00 43.69 N -ATOM 888 N LEU A 121 24.427 45.424 20.298 1.00 30.32 N -ATOM 889 CA LEU A 121 23.756 44.177 19.945 1.00 30.28 C -ATOM 890 C LEU A 121 24.232 43.750 18.545 1.00 30.14 C -ATOM 891 O LEU A 121 23.838 44.354 17.529 1.00 29.66 O -ATOM 892 CB LEU A 121 22.221 44.314 19.994 1.00 29.43 C -ATOM 893 CG LEU A 121 21.655 44.833 21.312 1.00 29.47 C -ATOM 894 CD1 LEU A 121 20.133 45.148 21.240 1.00 28.60 C -ATOM 895 CD2 LEU A 121 21.981 43.867 22.439 1.00 30.01 C -ATOM 896 N LYS A 122 25.104 42.739 18.514 1.00 30.23 N -ATOM 897 CA LYS A 122 25.692 42.242 17.272 1.00 30.77 C -ATOM 898 C LYS A 122 24.963 41.015 16.720 1.00 30.31 C -ATOM 899 O LYS A 122 24.994 40.748 15.520 1.00 30.97 O -ATOM 900 CB LYS A 122 27.150 41.856 17.492 1.00 31.10 C -ATOM 901 CG LYS A 122 27.932 42.857 18.270 1.00 34.55 C -ATOM 902 CD LYS A 122 28.254 44.068 17.435 1.00 37.21 C -ATOM 903 CE LYS A 122 29.578 44.637 17.921 1.00 41.85 C -ATOM 904 NZ LYS A 122 29.647 46.122 17.779 1.00 45.04 N -ATOM 905 N SER A 123 24.353 40.234 17.590 1.00 28.89 N -ATOM 906 CA SER A 123 23.593 39.080 17.119 1.00 29.25 C -ATOM 907 C SER A 123 22.504 38.756 18.130 1.00 29.01 C -ATOM 908 O SER A 123 22.439 39.361 19.199 1.00 29.07 O -ATOM 909 CB SER A 123 24.514 37.847 16.919 1.00 28.38 C -ATOM 910 OG SER A 123 24.909 37.328 18.187 1.00 30.05 O -ATOM 911 N ILE A 124 21.657 37.797 17.779 1.00 30.11 N -ATOM 912 CA ILE A 124 20.560 37.354 18.616 1.00 30.40 C -ATOM 913 C ILE A 124 21.044 36.980 20.043 1.00 31.66 C -ATOM 914 O ILE A 124 20.308 37.162 21.020 1.00 30.63 O -ATOM 915 CB ILE A 124 19.830 36.168 17.921 1.00 30.97 C -ATOM 916 CG1 ILE A 124 18.526 35.811 18.648 1.00 31.32 C -ATOM 917 CG2 ILE A 124 20.760 34.954 17.775 1.00 29.74 C -ATOM 918 CD1 ILE A 124 17.435 36.836 18.440 1.00 33.00 C -ATOM 919 N ASP A 125 22.286 36.472 20.155 1.00 32.15 N -ATOM 920 CA ASP A 125 22.858 36.041 21.449 1.00 32.32 C -ATOM 921 C ASP A 125 23.117 37.191 22.390 1.00 31.43 C -ATOM 922 O ASP A 125 23.291 36.996 23.591 1.00 30.73 O -ATOM 923 CB ASP A 125 24.180 35.287 21.239 1.00 33.54 C -ATOM 924 CG ASP A 125 24.027 34.128 20.295 1.00 36.42 C -ATOM 925 OD1 ASP A 125 23.000 33.427 20.372 1.00 38.93 O -ATOM 926 OD2 ASP A 125 24.912 33.948 19.440 1.00 41.72 O -ATOM 927 N ASP A 126 23.151 38.402 21.849 1.00 30.57 N -ATOM 928 CA ASP A 126 23.341 39.566 22.696 1.00 29.73 C -ATOM 929 C ASP A 126 22.028 40.092 23.290 1.00 29.14 C -ATOM 930 O ASP A 126 22.059 40.903 24.202 1.00 28.18 O -ATOM 931 CB ASP A 126 24.023 40.693 21.927 1.00 29.86 C -ATOM 932 CG ASP A 126 25.409 40.308 21.440 1.00 31.45 C -ATOM 933 OD1 ASP A 126 26.168 39.758 22.245 1.00 32.98 O -ATOM 934 OD2 ASP A 126 25.732 40.556 20.265 1.00 29.33 O -ATOM 935 N VAL A 127 20.891 39.663 22.750 1.00 28.12 N -ATOM 936 CA VAL A 127 19.600 40.132 23.270 1.00 27.54 C -ATOM 937 C VAL A 127 19.398 39.543 24.680 1.00 27.24 C -ATOM 938 O VAL A 127 19.603 38.361 24.881 1.00 26.18 O -ATOM 939 CB VAL A 127 18.442 39.723 22.332 1.00 27.46 C -ATOM 940 CG1 VAL A 127 17.094 40.157 22.913 1.00 26.88 C -ATOM 941 CG2 VAL A 127 18.645 40.294 20.923 1.00 27.36 C -ATOM 942 N PRO A 128 19.011 40.375 25.658 1.00 27.18 N -ATOM 943 CA PRO A 128 18.809 39.845 26.999 1.00 27.22 C -ATOM 944 C PRO A 128 17.902 38.614 26.998 1.00 27.86 C -ATOM 945 O PRO A 128 16.919 38.562 26.249 1.00 27.80 O -ATOM 946 CB PRO A 128 18.130 41.002 27.724 1.00 26.62 C -ATOM 947 CG PRO A 128 18.769 42.235 27.104 1.00 28.03 C -ATOM 948 CD PRO A 128 18.898 41.850 25.616 1.00 27.41 C -ATOM 949 N ALA A 129 18.221 37.627 27.834 1.00 27.80 N -ATOM 950 CA ALA A 129 17.410 36.415 27.870 1.00 28.35 C -ATOM 951 C ALA A 129 15.934 36.714 28.217 1.00 28.08 C -ATOM 952 O ALA A 129 15.010 36.049 27.696 1.00 27.99 O -ATOM 953 CB ALA A 129 18.005 35.402 28.850 1.00 28.21 C -ATOM 954 N TYR A 130 15.720 37.696 29.098 1.00 27.53 N -ATOM 955 CA TYR A 130 14.362 38.016 29.546 1.00 27.52 C -ATOM 956 C TYR A 130 13.523 38.512 28.358 1.00 27.66 C -ATOM 957 O TYR A 130 12.357 38.146 28.241 1.00 27.90 O -ATOM 958 CB TYR A 130 14.350 39.024 30.720 1.00 27.57 C -ATOM 959 CG TYR A 130 14.359 40.464 30.262 1.00 27.15 C -ATOM 960 CD1 TYR A 130 13.183 41.099 29.871 1.00 29.10 C -ATOM 961 CD2 TYR A 130 15.554 41.175 30.181 1.00 27.46 C -ATOM 962 CE1 TYR A 130 13.203 42.410 29.409 1.00 28.74 C -ATOM 963 CE2 TYR A 130 15.584 42.465 29.730 1.00 28.56 C -ATOM 964 CZ TYR A 130 14.398 43.072 29.348 1.00 29.54 C -ATOM 965 OH TYR A 130 14.443 44.369 28.916 1.00 34.94 O -ATOM 966 N LEU A 131 14.121 39.315 27.477 1.00 27.44 N -ATOM 967 CA LEU A 131 13.440 39.796 26.273 1.00 27.71 C -ATOM 968 C LEU A 131 13.166 38.664 25.271 1.00 27.69 C -ATOM 969 O LEU A 131 12.027 38.483 24.788 1.00 27.08 O -ATOM 970 CB LEU A 131 14.240 40.910 25.608 1.00 27.68 C -ATOM 971 CG LEU A 131 13.453 41.705 24.555 1.00 29.36 C -ATOM 972 CD1 LEU A 131 12.160 42.314 25.137 1.00 28.92 C -ATOM 973 CD2 LEU A 131 14.328 42.790 23.943 1.00 29.57 C -ATOM 974 N LYS A 132 14.211 37.901 24.953 1.00 27.29 N -ATOM 975 CA LYS A 132 14.038 36.681 24.180 1.00 27.37 C -ATOM 976 C LYS A 132 12.846 35.869 24.734 1.00 26.26 C -ATOM 977 O LYS A 132 11.948 35.517 23.986 1.00 26.14 O -ATOM 978 CB LYS A 132 15.336 35.843 24.172 1.00 28.31 C -ATOM 979 CG LYS A 132 16.386 36.314 23.170 1.00 30.56 C -ATOM 980 CD LYS A 132 17.511 35.269 22.990 1.00 33.45 C -ATOM 981 CE LYS A 132 18.727 35.625 23.835 1.00 35.02 C -ATOM 982 NZ LYS A 132 19.939 34.745 23.591 1.00 37.99 N -ATOM 983 N ASP A 133 12.839 35.580 26.034 1.00 25.23 N -ATOM 984 CA ASP A 133 11.757 34.796 26.662 1.00 24.89 C -ATOM 985 C ASP A 133 10.358 35.406 26.531 1.00 24.44 C -ATOM 986 O ASP A 133 9.383 34.687 26.328 1.00 23.26 O -ATOM 987 CB ASP A 133 12.027 34.569 28.159 1.00 24.84 C -ATOM 988 CG ASP A 133 13.166 33.593 28.417 1.00 28.52 C -ATOM 989 OD1 ASP A 133 13.562 32.849 27.490 1.00 31.06 O -ATOM 990 OD2 ASP A 133 13.678 33.593 29.552 1.00 31.64 O -ATOM 991 N GLN A 134 10.272 36.724 26.710 1.00 24.07 N -ATOM 992 CA GLN A 134 9.018 37.455 26.504 1.00 24.53 C -ATOM 993 C GLN A 134 8.504 37.351 25.062 1.00 24.16 C -ATOM 994 O GLN A 134 7.301 37.181 24.843 1.00 23.95 O -ATOM 995 CB GLN A 134 9.182 38.943 26.874 1.00 24.01 C -ATOM 996 CG GLN A 134 9.537 39.176 28.333 1.00 25.53 C -ATOM 997 CD GLN A 134 9.354 40.607 28.741 1.00 25.83 C -ATOM 998 OE1 GLN A 134 9.357 40.934 29.927 1.00 27.07 O -ATOM 999 NE2 GLN A 134 9.165 41.470 27.766 1.00 26.58 N -ATOM 1000 N ILE A 135 9.399 37.479 24.086 1.00 23.99 N -ATOM 1001 CA ILE A 135 8.997 37.405 22.674 1.00 24.11 C -ATOM 1002 C ILE A 135 8.444 36.023 22.366 1.00 25.38 C -ATOM 1003 O ILE A 135 7.381 35.878 21.727 1.00 25.45 O -ATOM 1004 CB ILE A 135 10.163 37.749 21.719 1.00 24.40 C -ATOM 1005 CG1 ILE A 135 10.565 39.216 21.892 1.00 23.65 C -ATOM 1006 CG2 ILE A 135 9.834 37.373 20.230 1.00 20.81 C -ATOM 1007 CD1 ILE A 135 11.932 39.561 21.290 1.00 21.20 C -ATOM 1008 N LYS A 136 9.138 35.006 22.859 1.00 25.73 N -ATOM 1009 CA LYS A 136 8.711 33.639 22.643 1.00 26.35 C -ATOM 1010 C LYS A 136 7.365 33.315 23.315 1.00 25.70 C -ATOM 1011 O LYS A 136 6.482 32.730 22.684 1.00 24.73 O -ATOM 1012 CB LYS A 136 9.839 32.696 23.079 1.00 27.12 C -ATOM 1013 CG LYS A 136 9.491 31.210 23.059 1.00 30.98 C -ATOM 1014 CD LYS A 136 10.754 30.398 23.454 1.00 38.08 C -ATOM 1015 CE LYS A 136 10.456 28.907 23.637 1.00 40.93 C -ATOM 1016 NZ LYS A 136 9.113 28.719 24.265 1.00 44.61 N -ATOM 1017 N HIS A 137 7.192 33.740 24.575 1.00 25.25 N -ATOM 1018 CA HIS A 137 5.900 33.625 25.278 1.00 24.60 C -ATOM 1019 C HIS A 137 4.757 34.338 24.511 1.00 23.92 C -ATOM 1020 O HIS A 137 3.645 33.784 24.345 1.00 23.75 O -ATOM 1021 CB HIS A 137 6.011 34.201 26.735 1.00 24.77 C -ATOM 1022 CG HIS A 137 4.761 34.005 27.551 1.00 25.29 C -ATOM 1023 ND1 HIS A 137 3.872 35.028 27.824 1.00 25.11 N -ATOM 1024 CD2 HIS A 137 4.228 32.888 28.111 1.00 22.39 C -ATOM 1025 CE1 HIS A 137 2.856 34.556 28.526 1.00 22.79 C -ATOM 1026 NE2 HIS A 137 3.047 33.259 28.714 1.00 26.13 N -ATOM 1027 N PHE A 138 5.022 35.573 24.066 1.00 23.23 N -ATOM 1028 CA PHE A 138 4.054 36.330 23.261 1.00 23.01 C -ATOM 1029 C PHE A 138 3.523 35.499 22.087 1.00 23.59 C -ATOM 1030 O PHE A 138 2.313 35.315 21.948 1.00 22.99 O -ATOM 1031 CB PHE A 138 4.588 37.688 22.737 1.00 21.76 C -ATOM 1032 CG PHE A 138 3.581 38.410 21.879 1.00 22.65 C -ATOM 1033 CD1 PHE A 138 2.538 39.114 22.458 1.00 20.19 C -ATOM 1034 CD2 PHE A 138 3.626 38.326 20.481 1.00 22.75 C -ATOM 1035 CE1 PHE A 138 1.566 39.746 21.672 1.00 20.14 C -ATOM 1036 CE2 PHE A 138 2.661 38.960 19.693 1.00 18.78 C -ATOM 1037 CZ PHE A 138 1.624 39.658 20.306 1.00 18.64 C -ATOM 1038 N PHE A 139 4.418 34.995 21.238 1.00 24.32 N -ATOM 1039 CA PHE A 139 3.966 34.206 20.091 1.00 25.35 C -ATOM 1040 C PHE A 139 3.302 32.873 20.431 1.00 26.07 C -ATOM 1041 O PHE A 139 2.369 32.435 19.751 1.00 26.11 O -ATOM 1042 CB PHE A 139 5.084 34.060 19.068 1.00 25.90 C -ATOM 1043 CG PHE A 139 5.393 35.342 18.370 1.00 27.31 C -ATOM 1044 CD1 PHE A 139 4.535 35.827 17.393 1.00 27.14 C -ATOM 1045 CD2 PHE A 139 6.515 36.088 18.718 1.00 26.77 C -ATOM 1046 CE1 PHE A 139 4.796 37.021 16.763 1.00 26.81 C -ATOM 1047 CE2 PHE A 139 6.786 37.279 18.088 1.00 27.38 C -ATOM 1048 CZ PHE A 139 5.915 37.750 17.096 1.00 27.03 C -ATOM 1049 N GLU A 140 3.747 32.247 21.508 1.00 27.11 N -ATOM 1050 CA GLU A 140 3.095 31.047 22.009 1.00 28.38 C -ATOM 1051 C GLU A 140 1.679 31.261 22.518 1.00 27.76 C -ATOM 1052 O GLU A 140 0.889 30.341 22.460 1.00 28.49 O -ATOM 1053 CB GLU A 140 3.937 30.396 23.110 1.00 28.39 C -ATOM 1054 CG GLU A 140 5.150 29.725 22.513 1.00 32.77 C -ATOM 1055 CD GLU A 140 5.926 28.953 23.534 1.00 35.86 C -ATOM 1056 OE1 GLU A 140 5.978 29.397 24.707 1.00 36.53 O -ATOM 1057 OE2 GLU A 140 6.491 27.914 23.149 1.00 38.06 O -ATOM 1058 N GLN A 141 1.358 32.463 22.996 1.00 27.27 N -ATOM 1059 CA GLN A 141 0.098 32.706 23.718 1.00 26.49 C -ATOM 1060 C GLN A 141 -0.891 33.712 23.103 1.00 26.43 C -ATOM 1061 O GLN A 141 -2.081 33.621 23.367 1.00 26.26 O -ATOM 1062 CB GLN A 141 0.390 33.129 25.170 1.00 26.70 C -ATOM 1063 CG GLN A 141 1.054 32.012 26.000 1.00 25.87 C -ATOM 1064 CD GLN A 141 0.143 30.811 26.137 1.00 27.04 C -ATOM 1065 OE1 GLN A 141 -1.078 30.964 26.127 1.00 26.18 O -ATOM 1066 NE2 GLN A 141 0.725 29.604 26.246 1.00 24.08 N -ATOM 1067 N TYR A 142 -0.431 34.650 22.283 1.00 25.24 N -ATOM 1068 CA TYR A 142 -1.324 35.723 21.835 1.00 25.93 C -ATOM 1069 C TYR A 142 -2.589 35.291 21.046 1.00 26.85 C -ATOM 1070 O TYR A 142 -3.600 36.023 21.036 1.00 25.86 O -ATOM 1071 CB TYR A 142 -0.550 36.851 21.122 1.00 24.57 C -ATOM 1072 CG TYR A 142 -0.237 36.657 19.645 1.00 24.88 C -ATOM 1073 CD1 TYR A 142 -0.614 37.636 18.697 1.00 23.74 C -ATOM 1074 CD2 TYR A 142 0.484 35.536 19.189 1.00 23.36 C -ATOM 1075 CE1 TYR A 142 -0.311 37.485 17.323 1.00 24.35 C -ATOM 1076 CE2 TYR A 142 0.795 35.381 17.840 1.00 23.20 C -ATOM 1077 CZ TYR A 142 0.408 36.350 16.908 1.00 24.71 C -ATOM 1078 OH TYR A 142 0.726 36.189 15.570 1.00 23.16 O -ATOM 1079 N LYS A 143 -2.538 34.106 20.425 1.00 27.36 N -ATOM 1080 CA LYS A 143 -3.656 33.620 19.616 1.00 28.59 C -ATOM 1081 C LYS A 143 -4.517 32.628 20.383 1.00 28.24 C -ATOM 1082 O LYS A 143 -5.450 32.069 19.814 1.00 28.26 O -ATOM 1083 CB LYS A 143 -3.179 32.956 18.314 1.00 28.24 C -ATOM 1084 CG LYS A 143 -2.845 33.904 17.177 1.00 30.18 C -ATOM 1085 CD LYS A 143 -2.035 33.123 16.136 1.00 31.30 C -ATOM 1086 CE LYS A 143 -2.057 33.788 14.782 1.00 32.46 C -ATOM 1087 NZ LYS A 143 -1.094 33.108 13.850 1.00 31.69 N -ATOM 1088 N ALA A 144 -4.214 32.446 21.666 1.00 28.11 N -ATOM 1089 CA ALA A 144 -4.911 31.489 22.514 1.00 28.53 C -ATOM 1090 C ALA A 144 -6.436 31.578 22.439 1.00 29.33 C -ATOM 1091 O ALA A 144 -7.109 30.576 22.625 1.00 29.02 O -ATOM 1092 CB ALA A 144 -4.446 31.610 23.979 1.00 27.54 C -ATOM 1093 N LEU A 145 -6.986 32.755 22.160 1.00 30.11 N -ATOM 1094 CA LEU A 145 -8.442 32.926 22.243 1.00 31.34 C -ATOM 1095 C LEU A 145 -9.115 33.091 20.884 1.00 33.19 C -ATOM 1096 O LEU A 145 -10.278 33.527 20.799 1.00 34.02 O -ATOM 1097 CB LEU A 145 -8.836 34.068 23.184 1.00 30.04 C -ATOM 1098 CG LEU A 145 -8.451 33.803 24.646 1.00 29.77 C -ATOM 1099 CD1 LEU A 145 -8.766 35.020 25.539 1.00 27.97 C -ATOM 1100 CD2 LEU A 145 -9.158 32.558 25.178 1.00 28.92 C -ATOM 1101 N GLU A 146 -8.404 32.722 19.826 1.00 34.54 N -ATOM 1102 CA GLU A 146 -9.007 32.685 18.497 1.00 36.61 C -ATOM 1103 C GLU A 146 -9.127 31.241 18.018 1.00 36.98 C -ATOM 1104 O GLU A 146 -8.131 30.520 17.940 1.00 37.28 O -ATOM 1105 CB GLU A 146 -8.198 33.548 17.528 1.00 36.66 C -ATOM 1106 CG GLU A 146 -8.473 35.038 17.752 1.00 39.16 C -ATOM 1107 CD GLU A 146 -7.212 35.867 17.769 1.00 41.76 C -ATOM 1108 OE1 GLU A 146 -6.523 35.925 16.724 1.00 46.57 O -ATOM 1109 OE2 GLU A 146 -6.907 36.480 18.809 1.00 41.40 O -ATOM 1110 N LYS A 147 -10.355 30.810 17.733 1.00 38.45 N -ATOM 1111 CA LYS A 147 -10.597 29.436 17.247 1.00 39.30 C -ATOM 1112 C LYS A 147 -9.881 29.202 15.918 1.00 39.80 C -ATOM 1113 O LYS A 147 -9.942 30.031 15.004 1.00 39.70 O -ATOM 1114 CB LYS A 147 -12.107 29.141 17.099 1.00 39.10 C -ATOM 1115 N GLY A 148 -9.196 28.069 15.813 1.00 40.78 N -ATOM 1116 CA GLY A 148 -8.523 27.724 14.574 1.00 41.89 C -ATOM 1117 C GLY A 148 -7.129 28.302 14.423 1.00 42.81 C -ATOM 1118 O GLY A 148 -6.505 28.152 13.366 1.00 43.25 O -ATOM 1119 N LYS A 149 -6.631 28.970 15.467 1.00 42.74 N -ATOM 1120 CA LYS A 149 -5.309 29.594 15.395 1.00 42.54 C -ATOM 1121 C LYS A 149 -4.401 29.040 16.468 1.00 42.14 C -ATOM 1122 O LYS A 149 -4.838 28.797 17.587 1.00 42.29 O -ATOM 1123 CB LYS A 149 -5.433 31.099 15.551 1.00 42.68 C -ATOM 1124 CG LYS A 149 -6.172 31.762 14.419 1.00 43.87 C -ATOM 1125 CD LYS A 149 -6.153 33.241 14.672 1.00 47.65 C -ATOM 1126 CE LYS A 149 -6.746 34.013 13.534 1.00 49.81 C -ATOM 1127 NZ LYS A 149 -6.712 35.448 13.904 1.00 50.78 N -ATOM 1128 N TRP A 150 -3.132 28.836 16.131 1.00 41.69 N -ATOM 1129 CA TRP A 150 -2.195 28.252 17.077 1.00 41.16 C -ATOM 1130 C TRP A 150 -0.741 28.515 16.617 1.00 40.09 C -ATOM 1131 O TRP A 150 -0.498 28.906 15.467 1.00 39.90 O -ATOM 1132 CB TRP A 150 -2.482 26.751 17.256 1.00 42.09 C -ATOM 1133 CG TRP A 150 -2.424 25.994 15.941 1.00 44.48 C -ATOM 1134 CD1 TRP A 150 -3.473 25.731 15.085 1.00 46.23 C -ATOM 1135 CD2 TRP A 150 -1.253 25.441 15.319 1.00 47.04 C -ATOM 1136 NE1 TRP A 150 -3.018 25.043 13.976 1.00 47.57 N -ATOM 1137 CE2 TRP A 150 -1.664 24.847 14.098 1.00 48.31 C -ATOM 1138 CE3 TRP A 150 0.104 25.389 15.673 1.00 47.74 C -ATOM 1139 CZ2 TRP A 150 -0.759 24.213 13.228 1.00 49.44 C -ATOM 1140 CZ3 TRP A 150 1.004 24.752 14.797 1.00 48.88 C -ATOM 1141 CH2 TRP A 150 0.565 24.178 13.597 1.00 48.25 C -ATOM 1142 N VAL A 151 0.209 28.336 17.527 1.00 38.25 N -ATOM 1143 CA VAL A 151 1.612 28.584 17.228 1.00 37.22 C -ATOM 1144 C VAL A 151 2.497 27.650 18.003 1.00 37.01 C -ATOM 1145 O VAL A 151 2.385 27.567 19.224 1.00 37.18 O -ATOM 1146 CB VAL A 151 2.064 29.984 17.683 1.00 36.92 C -ATOM 1147 CG1 VAL A 151 3.609 30.090 17.614 1.00 36.17 C -ATOM 1148 CG2 VAL A 151 1.374 31.052 16.887 1.00 37.01 C -ATOM 1149 N LYS A 152 3.411 26.983 17.306 1.00 37.00 N -ATOM 1150 CA LYS A 152 4.498 26.276 17.985 1.00 37.07 C -ATOM 1151 C LYS A 152 5.842 26.914 17.600 1.00 36.86 C -ATOM 1152 O LYS A 152 6.130 27.120 16.424 1.00 36.56 O -ATOM 1153 CB LYS A 152 4.462 24.764 17.671 1.00 37.12 C -ATOM 1154 N VAL A 153 6.626 27.265 18.610 1.00 37.55 N -ATOM 1155 CA VAL A 153 7.952 27.825 18.420 1.00 38.67 C -ATOM 1156 C VAL A 153 8.974 26.699 18.221 1.00 39.79 C -ATOM 1157 O VAL A 153 9.112 25.831 19.090 1.00 40.45 O -ATOM 1158 CB VAL A 153 8.383 28.679 19.647 1.00 38.52 C -ATOM 1159 CG1 VAL A 153 9.857 29.052 19.544 1.00 38.07 C -ATOM 1160 CG2 VAL A 153 7.497 29.925 19.786 1.00 37.74 C -ATOM 1161 N GLU A 154 9.687 26.708 17.090 1.00 40.04 N -ATOM 1162 CA GLU A 154 10.734 25.724 16.843 1.00 40.39 C -ATOM 1163 C GLU A 154 12.069 26.146 17.482 1.00 39.58 C -ATOM 1164 O GLU A 154 12.725 25.346 18.138 1.00 39.63 O -ATOM 1165 CB GLU A 154 10.906 25.461 15.339 1.00 40.95 C -ATOM 1166 CG GLU A 154 9.594 25.360 14.525 1.00 44.59 C -ATOM 1167 CD GLU A 154 8.715 24.132 14.863 1.00 51.27 C -ATOM 1168 OE1 GLU A 154 9.167 23.234 15.624 1.00 52.36 O -ATOM 1169 OE2 GLU A 154 7.557 24.071 14.356 1.00 52.58 O -ATOM 1170 N GLY A 155 12.483 27.394 17.293 1.00 38.48 N -ATOM 1171 CA GLY A 155 13.721 27.866 17.929 1.00 37.24 C -ATOM 1172 C GLY A 155 14.311 29.122 17.304 1.00 36.18 C -ATOM 1173 O GLY A 155 13.750 29.666 16.353 1.00 36.76 O -ATOM 1174 N TRP A 156 15.439 29.571 17.847 1.00 34.89 N -ATOM 1175 CA TRP A 156 16.155 30.742 17.367 1.00 34.38 C -ATOM 1176 C TRP A 156 17.174 30.356 16.302 1.00 34.36 C -ATOM 1177 O TRP A 156 17.674 29.239 16.305 1.00 35.16 O -ATOM 1178 CB TRP A 156 16.906 31.397 18.520 1.00 33.47 C -ATOM 1179 CG TRP A 156 16.018 31.843 19.632 1.00 33.27 C -ATOM 1180 CD1 TRP A 156 15.803 31.203 20.822 1.00 33.92 C -ATOM 1181 CD2 TRP A 156 15.201 33.031 19.662 1.00 30.60 C -ATOM 1182 NE1 TRP A 156 14.910 31.924 21.596 1.00 32.30 N -ATOM 1183 CE2 TRP A 156 14.523 33.044 20.909 1.00 31.40 C -ATOM 1184 CE3 TRP A 156 14.973 34.070 18.760 1.00 31.26 C -ATOM 1185 CZ2 TRP A 156 13.630 34.062 21.273 1.00 30.75 C -ATOM 1186 CZ3 TRP A 156 14.095 35.104 19.135 1.00 32.01 C -ATOM 1187 CH2 TRP A 156 13.444 35.090 20.380 1.00 29.67 C -ATOM 1188 N ASP A 157 17.469 31.272 15.386 1.00 33.86 N -ATOM 1189 CA ASP A 157 18.577 31.106 14.437 1.00 32.34 C -ATOM 1190 C ASP A 157 19.263 32.457 14.275 1.00 31.51 C -ATOM 1191 O ASP A 157 18.729 33.478 14.724 1.00 31.36 O -ATOM 1192 CB ASP A 157 18.063 30.581 13.096 1.00 32.87 C -ATOM 1193 CG ASP A 157 19.050 29.623 12.430 1.00 33.29 C -ATOM 1194 OD1 ASP A 157 20.267 29.756 12.646 1.00 34.65 O -ATOM 1195 OD2 ASP A 157 18.612 28.741 11.682 1.00 34.01 O -ATOM 1196 N GLY A 158 20.444 32.474 13.656 1.00 29.77 N -ATOM 1197 CA GLY A 158 21.324 33.641 13.683 1.00 27.83 C -ATOM 1198 C GLY A 158 21.263 34.514 12.449 1.00 27.09 C -ATOM 1199 O GLY A 158 20.326 34.406 11.659 1.00 26.51 O -ATOM 1200 N ILE A 159 22.272 35.374 12.288 1.00 26.02 N -ATOM 1201 CA ILE A 159 22.293 36.402 11.250 1.00 26.35 C -ATOM 1202 C ILE A 159 22.280 35.847 9.827 1.00 26.41 C -ATOM 1203 O ILE A 159 21.581 36.376 8.946 1.00 25.21 O -ATOM 1204 CB ILE A 159 23.504 37.366 11.418 1.00 26.70 C -ATOM 1205 CG1 ILE A 159 23.361 38.233 12.685 1.00 28.08 C -ATOM 1206 CG2 ILE A 159 23.650 38.301 10.246 1.00 26.01 C -ATOM 1207 CD1 ILE A 159 24.668 39.003 13.012 1.00 28.81 C -ATOM 1208 N ASP A 160 23.038 34.772 9.597 1.00 26.15 N -ATOM 1209 CA ASP A 160 23.112 34.177 8.249 1.00 25.96 C -ATOM 1210 C ASP A 160 21.756 33.642 7.817 1.00 24.88 C -ATOM 1211 O ASP A 160 21.374 33.777 6.665 1.00 24.73 O -ATOM 1212 CB ASP A 160 24.116 33.010 8.205 1.00 26.67 C -ATOM 1213 CG ASP A 160 25.541 33.433 8.520 1.00 29.50 C -ATOM 1214 OD1 ASP A 160 25.934 34.574 8.239 1.00 30.48 O -ATOM 1215 OD2 ASP A 160 26.293 32.584 9.050 1.00 35.45 O -ATOM 1216 N ALA A 161 21.032 32.999 8.728 1.00 23.99 N -ATOM 1217 CA ALA A 161 19.680 32.532 8.392 1.00 23.50 C -ATOM 1218 C ALA A 161 18.751 33.702 8.082 1.00 23.21 C -ATOM 1219 O ALA A 161 17.935 33.606 7.165 1.00 24.21 O -ATOM 1220 CB ALA A 161 19.115 31.701 9.495 1.00 23.26 C -ATOM 1221 N ALA A 162 18.894 34.805 8.824 1.00 23.21 N -ATOM 1222 CA ALA A 162 18.103 36.027 8.571 1.00 23.79 C -ATOM 1223 C ALA A 162 18.362 36.572 7.170 1.00 23.81 C -ATOM 1224 O ALA A 162 17.440 36.955 6.439 1.00 23.83 O -ATOM 1225 CB ALA A 162 18.394 37.118 9.643 1.00 22.09 C -ATOM 1226 N HIS A 163 19.642 36.604 6.796 1.00 24.63 N -ATOM 1227 CA HIS A 163 20.029 37.073 5.475 1.00 24.48 C -ATOM 1228 C HIS A 163 19.483 36.211 4.326 1.00 24.40 C -ATOM 1229 O HIS A 163 19.062 36.754 3.319 1.00 24.93 O -ATOM 1230 CB HIS A 163 21.542 37.247 5.411 1.00 24.71 C -ATOM 1231 CG HIS A 163 22.027 38.433 6.186 1.00 24.48 C -ATOM 1232 ND1 HIS A 163 23.346 38.602 6.556 1.00 25.05 N -ATOM 1233 CD2 HIS A 163 21.361 39.517 6.658 1.00 24.82 C -ATOM 1234 CE1 HIS A 163 23.478 39.748 7.207 1.00 26.44 C -ATOM 1235 NE2 HIS A 163 22.286 40.321 7.286 1.00 25.55 N -ATOM 1236 N LYS A 164 19.483 34.885 4.485 1.00 24.88 N -ATOM 1237 CA LYS A 164 18.856 33.977 3.518 1.00 26.27 C -ATOM 1238 C LYS A 164 17.384 34.322 3.344 1.00 25.61 C -ATOM 1239 O LYS A 164 16.892 34.453 2.231 1.00 25.21 O -ATOM 1240 CB LYS A 164 18.864 32.524 4.009 1.00 25.32 C -ATOM 1241 CG LYS A 164 20.048 31.657 3.721 1.00 30.29 C -ATOM 1242 CD LYS A 164 19.613 30.121 3.720 1.00 34.26 C -ATOM 1243 CE LYS A 164 18.052 29.873 3.503 1.00 36.52 C -ATOM 1244 NZ LYS A 164 17.403 29.714 2.102 1.00 34.41 N -ATOM 1245 N GLU A 165 16.667 34.392 4.472 1.00 25.78 N -ATOM 1246 CA GLU A 165 15.244 34.755 4.441 1.00 25.93 C -ATOM 1247 C GLU A 165 15.002 36.070 3.666 1.00 25.03 C -ATOM 1248 O GLU A 165 14.080 36.172 2.864 1.00 25.31 O -ATOM 1249 CB GLU A 165 14.664 34.826 5.886 1.00 26.24 C -ATOM 1250 CG GLU A 165 13.251 35.378 5.967 1.00 28.43 C -ATOM 1251 CD GLU A 165 12.136 34.349 5.679 1.00 34.26 C -ATOM 1252 OE1 GLU A 165 12.441 33.135 5.549 1.00 30.46 O -ATOM 1253 OE2 GLU A 165 10.938 34.777 5.629 1.00 38.23 O -ATOM 1254 N ILE A 166 15.831 37.076 3.918 1.00 25.30 N -ATOM 1255 CA ILE A 166 15.736 38.343 3.199 1.00 25.03 C -ATOM 1256 C ILE A 166 16.037 38.168 1.671 1.00 26.31 C -ATOM 1257 O ILE A 166 15.225 38.577 0.837 1.00 25.19 O -ATOM 1258 CB ILE A 166 16.663 39.415 3.819 1.00 24.79 C -ATOM 1259 CG1 ILE A 166 16.224 39.786 5.264 1.00 23.32 C -ATOM 1260 CG2 ILE A 166 16.705 40.658 2.942 1.00 23.43 C -ATOM 1261 CD1 ILE A 166 17.231 40.715 6.023 1.00 17.43 C -ATOM 1262 N THR A 167 17.178 37.556 1.314 1.00 26.73 N -ATOM 1263 CA THR A 167 17.499 37.327 -0.131 1.00 27.90 C -ATOM 1264 C THR A 167 16.388 36.528 -0.853 1.00 27.76 C -ATOM 1265 O THR A 167 15.948 36.919 -1.928 1.00 27.97 O -ATOM 1266 CB THR A 167 18.896 36.655 -0.343 1.00 27.77 C -ATOM 1267 OG1 THR A 167 19.912 37.462 0.265 1.00 29.19 O -ATOM 1268 CG2 THR A 167 19.220 36.514 -1.852 1.00 28.06 C -ATOM 1269 N ASP A 168 15.910 35.440 -0.241 1.00 28.23 N -ATOM 1270 CA ASP A 168 14.773 34.697 -0.801 1.00 29.21 C -ATOM 1271 C ASP A 168 13.567 35.601 -1.013 1.00 29.51 C -ATOM 1272 O ASP A 168 12.931 35.580 -2.066 1.00 29.99 O -ATOM 1273 CB ASP A 168 14.390 33.492 0.087 1.00 29.78 C -ATOM 1274 CG ASP A 168 15.502 32.434 0.167 1.00 30.95 C -ATOM 1275 OD1 ASP A 168 16.467 32.528 -0.605 1.00 30.65 O -ATOM 1276 OD2 ASP A 168 15.430 31.526 1.015 1.00 33.38 O -ATOM 1277 N GLY A 169 13.244 36.407 -0.004 1.00 29.89 N -ATOM 1278 CA GLY A 169 12.060 37.272 -0.081 1.00 29.50 C -ATOM 1279 C GLY A 169 12.136 38.287 -1.199 1.00 29.28 C -ATOM 1280 O GLY A 169 11.170 38.520 -1.900 1.00 27.96 O -ATOM 1281 N VAL A 170 13.285 38.927 -1.335 1.00 29.71 N -ATOM 1282 CA VAL A 170 13.504 39.857 -2.440 1.00 31.10 C -ATOM 1283 C VAL A 170 13.337 39.173 -3.832 1.00 33.09 C -ATOM 1284 O VAL A 170 12.599 39.672 -4.699 1.00 33.41 O -ATOM 1285 CB VAL A 170 14.887 40.574 -2.309 1.00 30.44 C -ATOM 1286 CG1 VAL A 170 15.188 41.389 -3.551 1.00 29.32 C -ATOM 1287 CG2 VAL A 170 14.898 41.459 -1.071 1.00 29.13 C -ATOM 1288 N ALA A 171 14.016 38.036 -4.018 1.00 34.61 N -ATOM 1289 CA ALA A 171 13.922 37.243 -5.237 1.00 36.15 C -ATOM 1290 C ALA A 171 12.473 36.854 -5.526 1.00 37.93 C -ATOM 1291 O ALA A 171 11.950 37.182 -6.592 1.00 38.85 O -ATOM 1292 CB ALA A 171 14.792 35.993 -5.116 1.00 35.84 C -ATOM 1293 N ASN A 172 11.819 36.168 -4.583 1.00 38.94 N -ATOM 1294 CA ASN A 172 10.408 35.776 -4.743 1.00 40.34 C -ATOM 1295 C ASN A 172 9.461 36.914 -5.139 1.00 40.57 C -ATOM 1296 O ASN A 172 8.516 36.702 -5.886 1.00 40.25 O -ATOM 1297 CB ASN A 172 9.869 35.131 -3.470 1.00 40.63 C -ATOM 1298 CG ASN A 172 10.583 33.848 -3.112 1.00 44.22 C -ATOM 1299 OD1 ASN A 172 11.398 33.318 -3.886 1.00 46.04 O -ATOM 1300 ND2 ASN A 172 10.284 33.332 -1.914 1.00 48.20 N -ATOM 1301 N PHE A 173 9.695 38.113 -4.617 1.00 41.30 N -ATOM 1302 CA PHE A 173 8.810 39.231 -4.915 1.00 42.45 C -ATOM 1303 C PHE A 173 8.895 39.652 -6.391 1.00 44.05 C -ATOM 1304 O PHE A 173 7.898 40.045 -6.998 1.00 43.32 O -ATOM 1305 CB PHE A 173 9.118 40.424 -4.012 1.00 41.78 C -ATOM 1306 CG PHE A 173 8.245 41.622 -4.272 1.00 39.79 C -ATOM 1307 CD1 PHE A 173 6.955 41.682 -3.765 1.00 39.49 C -ATOM 1308 CD2 PHE A 173 8.711 42.689 -5.021 1.00 37.99 C -ATOM 1309 CE1 PHE A 173 6.150 42.795 -4.005 1.00 38.53 C -ATOM 1310 CE2 PHE A 173 7.911 43.802 -5.262 1.00 36.13 C -ATOM 1311 CZ PHE A 173 6.631 43.850 -4.757 1.00 37.09 C -ATOM 1312 N LYS A 174 10.098 39.581 -6.955 1.00 46.01 N -ATOM 1313 CA LYS A 174 10.321 39.983 -8.344 1.00 48.08 C -ATOM 1314 C LYS A 174 9.802 38.906 -9.300 1.00 49.84 C -ATOM 1315 O LYS A 174 9.753 39.095 -10.511 1.00 50.31 O -ATOM 1316 CB LYS A 174 11.802 40.337 -8.564 1.00 47.73 C -ATOM 1317 CG LYS A 174 12.190 41.554 -7.729 1.00 46.64 C -ATOM 1318 CD LYS A 174 13.657 41.609 -7.418 1.00 45.19 C -ATOM 1319 CE LYS A 174 14.379 42.456 -8.444 1.00 45.69 C -ATOM 1320 NZ LYS A 174 15.857 42.279 -8.351 1.00 44.08 N -ATOM 1321 N LYS A 175 9.382 37.788 -8.715 1.00 52.11 N -ATOM 1322 CA LYS A 175 8.602 36.759 -9.396 1.00 54.14 C -ATOM 1323 C LYS A 175 9.423 35.473 -9.415 1.00 54.68 C -ATOM 1324 O LYS A 175 9.136 34.467 -8.751 1.00 55.07 O -ATOM 1325 CB LYS A 175 8.214 37.214 -10.809 1.00 54.60 C -ATOM 1326 CG LYS A 175 6.957 36.545 -11.369 1.00 57.59 C -ATOM 1327 CD LYS A 175 6.501 37.199 -12.700 1.00 61.87 C -ATOM 1328 CE LYS A 175 7.706 37.673 -13.531 1.00 63.51 C -ATOM 1329 NZ LYS A 175 8.861 36.709 -13.496 1.00 63.20 N -ATOM 1330 OXT LYS A 175 10.451 35.432 -10.086 1.00 55.71 O -TER 1331 LYS A 175 -HETATM 1332 K K A 176 24.990 43.276 0.005 0.50 24.45 K -HETATM 1333 NA NA A 177 1.633 34.181 11.897 1.00 26.73 NA -HETATM 1334 NA NA A 178 6.489 35.143 8.444 1.00 30.89 NA -HETATM 1335 P1 POP A 179 1.233 37.542 11.212 1.00 32.68 P -HETATM 1336 O1 POP A 179 1.910 38.831 11.612 1.00 32.62 O -HETATM 1337 O2 POP A 179 1.288 37.475 9.712 1.00 33.46 O -HETATM 1338 O3 POP A 179 1.948 36.362 11.841 1.00 30.47 O -HETATM 1339 O POP A 179 -0.339 37.641 11.573 1.00 33.48 O -HETATM 1340 P2 POP A 179 -1.193 36.552 12.370 1.00 36.05 P -HETATM 1341 O4 POP A 179 -2.611 36.792 11.954 1.00 33.39 O -HETATM 1342 O5 POP A 179 -1.079 36.873 13.870 1.00 33.69 O -HETATM 1343 O6 POP A 179 -0.735 35.128 12.124 1.00 33.11 O -HETATM 1344 O1 PG4 A 180 25.225 36.156 6.596 1.00 42.63 O -HETATM 1345 C1 PG4 A 180 25.070 35.591 5.302 1.00 44.20 C -HETATM 1346 C2 PG4 A 180 25.728 36.597 4.386 1.00 46.03 C -HETATM 1347 O2 PG4 A 180 24.774 36.857 3.380 1.00 48.37 O -HETATM 1348 C3 PG4 A 180 25.201 37.981 2.614 1.00 47.94 C -HETATM 1349 C4 PG4 A 180 25.268 39.174 3.548 1.00 46.48 C -HETATM 1350 O3 PG4 A 180 26.617 39.507 3.811 1.00 45.59 O -HETATM 1351 C5 PG4 A 180 26.819 40.888 3.597 1.00 45.33 C -HETATM 1352 C6 PG4 A 180 28.266 41.161 3.954 1.00 47.26 C -HETATM 1353 O4 PG4 A 180 28.982 41.378 2.738 1.00 48.16 O -HETATM 1354 C7 PG4 A 180 30.163 40.616 2.604 1.00 47.41 C -HETATM 1355 C8 PG4 A 180 31.331 41.437 3.117 1.00 51.14 C -HETATM 1356 O5 PG4 A 180 32.081 40.607 4.011 1.00 53.41 O -HETATM 1357 C1 PEG A 181 13.856 28.176 23.722 1.00 59.47 C -HETATM 1358 O1 PEG A 181 14.416 29.487 23.735 1.00 59.79 O -HETATM 1359 C2 PEG A 181 13.605 27.741 22.291 1.00 59.20 C -HETATM 1360 O2 PEG A 181 12.908 26.499 22.379 1.00 59.79 O -HETATM 1361 C3 PEG A 181 11.848 26.393 21.440 1.00 59.65 C -HETATM 1362 C4 PEG A 181 10.883 25.309 21.906 1.00 59.90 C -HETATM 1363 O4 PEG A 181 10.045 25.835 22.942 1.00 58.85 O -HETATM 1364 C1 PEG A 182 19.721 56.811 7.363 1.00 56.17 C -HETATM 1365 O1 PEG A 182 18.409 56.724 7.966 1.00 55.97 O -HETATM 1366 C2 PEG A 182 20.835 56.288 8.271 1.00 54.49 C -HETATM 1367 O2 PEG A 182 21.824 57.291 8.516 1.00 56.31 O -HETATM 1368 C3 PEG A 182 23.176 56.838 8.332 1.00 57.82 C -HETATM 1369 C4 PEG A 182 23.815 57.479 7.094 1.00 58.58 C -HETATM 1370 O4 PEG A 182 24.621 56.536 6.357 1.00 59.04 O -HETATM 1371 O HOH A 183 -6.268 35.297 21.123 1.00 22.39 O -HETATM 1372 O HOH A 184 18.291 50.223 3.964 1.00 24.68 O -HETATM 1373 O HOH A 185 22.029 42.728 8.623 1.00 20.47 O -HETATM 1374 O HOH A 186 15.767 55.114 9.164 1.00 20.81 O -HETATM 1375 O HOH A 187 0.754 45.724 20.847 1.00 21.83 O -HETATM 1376 O HOH A 188 11.338 47.709 21.125 1.00 19.21 O -HETATM 1377 O HOH A 189 19.695 33.152 21.711 1.00 38.29 O -HETATM 1378 O HOH A 190 10.491 50.293 22.101 1.00 18.65 O -HETATM 1379 O HOH A 191 4.344 42.176 9.606 1.00 23.68 O -HETATM 1380 O HOH A 192 22.154 49.578 16.234 1.00 24.18 O -HETATM 1381 O HOH A 193 19.540 33.045 0.367 0.50 15.02 O -HETATM 1382 O HOH A 194 -0.281 31.958 19.977 1.00 27.04 O -HETATM 1383 O HOH A 195 0.714 43.186 11.724 1.00 31.86 O -HETATM 1384 O HOH A 196 3.567 51.947 22.586 1.00 23.51 O -HETATM 1385 O HOH A 197 -1.180 48.644 17.742 1.00 15.53 O -HETATM 1386 O HOH A 198 1.948 54.836 16.377 1.00 21.93 O -HETATM 1387 O HOH A 199 2.509 44.733 28.229 1.00 21.51 O -HETATM 1388 O HOH A 200 2.391 38.378 14.597 1.00 23.11 O -HETATM 1389 O HOH A 201 1.535 33.854 14.371 1.00 27.83 O -HETATM 1390 O HOH A 202 -6.330 29.284 19.591 1.00 32.67 O -HETATM 1391 O HOH A 203 -2.980 54.585 7.752 1.00 25.04 O -HETATM 1392 O HOH A 204 -1.529 52.313 21.859 1.00 28.95 O -HETATM 1393 O HOH A 205 -4.219 37.228 18.172 1.00 29.05 O -HETATM 1394 O HOH A 206 -9.725 38.390 17.936 1.00 25.82 O -HETATM 1395 O HOH A 207 -0.251 50.231 15.527 1.00 41.88 O -HETATM 1396 O HOH A 208 -7.548 43.260 22.219 1.00 19.57 O -HETATM 1397 O HOH A 209 24.427 35.212 14.096 1.00 31.41 O -HETATM 1398 O HOH A 210 17.913 38.657 31.156 1.00 36.76 O -HETATM 1399 O HOH A 211 23.606 42.865 12.451 1.00 25.35 O -HETATM 1400 O HOH A 212 -10.993 36.660 20.173 1.00 34.07 O -HETATM 1401 O HOH A 213 12.726 35.081 31.604 1.00 41.53 O -HETATM 1402 O HOH A 214 11.555 34.813 2.535 1.00 32.40 O -HETATM 1403 O HOH A 215 26.985 45.074 13.907 1.00 33.93 O -HETATM 1404 O HOH A 216 22.305 31.774 11.176 1.00 27.99 O -HETATM 1405 O HOH A 217 -5.311 51.156 18.105 1.00 23.06 O -HETATM 1406 O HOH A 218 4.813 38.197 26.560 1.00 30.39 O -HETATM 1407 O HOH A 219 16.429 31.381 6.556 1.00 31.04 O -HETATM 1408 O HOH A 220 2.094 31.244 8.621 1.00 39.67 O -HETATM 1409 O HOH A 221 3.282 37.464 7.811 1.00 36.79 O -HETATM 1410 O HOH A 222 12.081 42.928 -4.465 1.00 35.63 O -HETATM 1411 O HOH A 223 10.457 52.853 26.328 1.00 29.83 O -HETATM 1412 O HOH A 224 -10.834 37.817 15.537 1.00 32.13 O -HETATM 1413 O HOH A 225 11.844 46.500 23.826 1.00 35.48 O -HETATM 1414 O HOH A 226 4.136 40.856 6.472 1.00 40.41 O -HETATM 1415 O HOH A 227 27.046 47.404 15.617 1.00 32.79 O -HETATM 1416 O HOH A 228 27.357 54.793 8.601 1.00 45.22 O -HETATM 1417 O HOH A 229 23.653 47.745 22.742 1.00 50.33 O -HETATM 1418 O HOH A 230 13.464 46.940 -3.502 1.00 32.04 O -HETATM 1419 O HOH A 231 3.976 32.286 14.525 1.00 31.56 O -HETATM 1420 O HOH A 232 20.596 34.827 26.319 1.00 49.91 O -HETATM 1421 O HOH A 233 0.268 53.053 17.314 1.00 42.31 O -HETATM 1422 O HOH A 234 8.635 54.732 26.919 1.00 33.52 O -HETATM 1423 O HOH A 235 8.723 45.643 25.830 1.00 31.33 O -HETATM 1424 O HOH A 236 9.525 50.219 24.646 1.00 32.19 O -HETATM 1425 O HOH A 237 29.165 40.813 21.487 1.00 56.55 O -HETATM 1426 O HOH A 238 2.494 40.055 8.917 1.00 36.15 O -HETATM 1427 O HOH A 239 -0.777 34.809 9.090 1.00 37.11 O -HETATM 1428 O HOH A 240 23.455 48.536 9.084 1.00 28.44 O -HETATM 1429 O HOH A 241 24.600 49.610 11.229 1.00 23.81 O -HETATM 1430 O HOH A 242 21.015 49.121 7.957 1.00 22.66 O -HETATM 1431 O HOH A 243 24.242 43.201 9.915 1.00 27.87 O -HETATM 1432 O HOH A 244 26.271 42.655 13.711 1.00 28.13 O -HETATM 1433 O HOH A 245 5.960 36.600 6.289 1.00 41.50 O -HETATM 1434 O HOH A 246 18.246 32.111 23.785 1.00 56.31 O -HETATM 1435 O HOH A 247 7.627 32.876 7.134 1.00 33.79 O -HETATM 1436 O HOH A 248 1.165 51.316 -0.972 1.00 46.31 O -HETATM 1437 O HOH A 249 1.154 41.748 26.990 1.00 28.03 O -HETATM 1438 O HOH A 250 5.939 26.535 21.149 1.00 44.12 O -HETATM 1439 O HOH A 251 -5.540 43.055 28.186 1.00 26.47 O -HETATM 1440 O HOH A 252 11.949 30.493 27.231 1.00 52.78 O -HETATM 1441 O HOH A 253 13.331 24.495 13.440 1.00 52.00 O -HETATM 1442 O HOH A 254 -1.435 29.723 20.052 1.00 52.22 O -HETATM 1443 O HOH A 255 2.115 43.165 6.250 1.00 34.91 O -HETATM 1444 O HOH A 256 15.992 53.085 0.933 1.00 34.04 O -HETATM 1445 O HOH A 257 2.292 33.719 9.368 1.00 44.24 O -HETATM 1446 O HOH A 258 3.626 29.350 26.403 1.00 42.97 O -HETATM 1447 O HOH A 259 -3.063 50.429 19.160 1.00 33.64 O -HETATM 1448 O HOH A 260 -4.016 34.810 12.023 1.00 43.84 O -HETATM 1449 O HOH A 261 -7.025 43.005 7.425 1.00 50.38 O -HETATM 1450 O HOH A 262 20.664 37.966 29.449 1.00 39.40 O -HETATM 1451 O HOH A 263 8.219 36.489 7.242 1.00 45.22 O -HETATM 1452 O HOH A 264 7.603 30.314 26.808 1.00 49.95 O -HETATM 1453 O HOH A 265 27.192 38.462 19.035 1.00 38.71 O -HETATM 1454 O HOH A 266 -3.725 41.084 29.707 1.00 44.44 O -HETATM 1455 O HOH A 267 -3.184 38.130 9.900 1.00 31.98 O -HETATM 1456 O HOH A 268 -6.968 37.923 11.495 1.00 40.84 O -HETATM 1457 O HOH A 269 15.958 47.852 -2.923 1.00 44.94 O -HETATM 1458 O HOH A 270 13.106 37.129 -9.048 1.00 35.12 O -HETATM 1459 O HOH A 271 23.944 34.080 16.627 1.00 56.20 O -HETATM 1460 O HOH A 272 17.584 52.420 -1.888 1.00 38.11 O -HETATM 1461 O HOH A 273 5.521 45.450 -0.564 1.00 47.04 O -HETATM 1462 O HOH A 274 25.459 49.006 4.506 1.00 54.02 O -HETATM 1463 O HOH A 275 16.595 27.943 19.928 1.00 49.01 O -HETATM 1464 O HOH A 276 22.019 36.726 26.870 1.00 56.59 O -HETATM 1465 O HOH A 277 10.474 36.654 8.412 1.00 45.47 O -HETATM 1466 O HOH A 278 24.611 33.020 11.703 1.00 47.62 O -HETATM 1467 O HOH A 279 26.899 46.740 4.551 1.00 52.92 O -HETATM 1468 O HOH A 280 6.994 29.354 29.500 1.00 59.06 O -HETATM 1469 O HOH A 281 1.016 41.471 9.152 1.00 46.63 O -HETATM 1470 O HOH A 282 -3.738 28.411 20.723 1.00 58.68 O -HETATM 1471 O HOH A 283 14.325 31.639 5.778 1.00 49.26 O -HETATM 1472 O HOH A 284 27.777 37.727 7.983 1.00 49.01 O -HETATM 1473 O HOH A 285 11.301 44.913 29.125 1.00 47.44 O -HETATM 1474 O HOH A 286 -3.722 51.289 27.893 1.00 28.88 O -HETATM 1475 O HOH A 287 5.173 46.827 -3.289 1.00 59.99 O -HETATM 1476 O HOH A 288 -9.268 38.914 11.481 1.00 39.62 O -HETATM 1477 O HOH A 289 9.346 31.934 27.060 1.00 45.27 O -HETATM 1478 O HOH A 290 24.327 46.350 8.439 1.00 39.23 O -HETATM 1479 O HOH A 291 17.766 26.234 14.240 1.00 58.80 O -HETATM 1480 O HOH A 292 14.667 53.897 27.017 1.00 44.45 O -HETATM 1481 O HOH A 293 13.540 30.919 2.872 1.00 48.68 O -HETATM 1482 O HOH A 294 13.812 54.578 29.178 1.00 37.62 O -CONECT 70 1332 -CONECT 75 1332 -CONECT 94 1332 -CONECT 535 1334 -CONECT 734 1333 -CONECT 767 1334 -CONECT 768 1333 -CONECT 772 1334 -CONECT 1332 70 75 94 -CONECT 1333 734 768 1338 1343 -CONECT 1333 1389 1445 -CONECT 1334 535 767 772 1433 -CONECT 1334 1435 1451 -CONECT 1335 1336 1337 1338 1339 -CONECT 1336 1335 -CONECT 1337 1335 -CONECT 1338 1333 1335 -CONECT 1339 1335 1340 -CONECT 1340 1339 1341 1342 1343 -CONECT 1341 1340 -CONECT 1342 1340 -CONECT 1343 1333 1340 -CONECT 1344 1345 -CONECT 1345 1344 1346 -CONECT 1346 1345 1347 -CONECT 1347 1346 1348 -CONECT 1348 1347 1349 -CONECT 1349 1348 1350 -CONECT 1350 1349 1351 -CONECT 1351 1350 1352 -CONECT 1352 1351 1353 -CONECT 1353 1352 1354 -CONECT 1354 1353 1355 -CONECT 1355 1354 1356 -CONECT 1356 1355 -CONECT 1357 1358 1359 -CONECT 1358 1357 -CONECT 1359 1357 1360 -CONECT 1360 1359 1361 -CONECT 1361 1360 1362 -CONECT 1362 1361 1363 -CONECT 1363 1362 -CONECT 1364 1365 1366 -CONECT 1365 1364 -CONECT 1366 1364 1367 -CONECT 1367 1366 1368 -CONECT 1368 1367 1369 -CONECT 1369 1368 1370 -CONECT 1370 1369 -CONECT 1389 1333 -CONECT 1433 1334 -CONECT 1435 1334 -CONECT 1445 1333 -CONECT 1451 1334 -MASTER 471 0 7 5 9 0 13 6 1481 1 54 16 -END diff --git a/pyaptamer/datasets/loader/__init__.py b/pyaptamer/datasets/loader/__init__.py index d7ee039f..1fc3252a 100644 --- a/pyaptamer/datasets/loader/__init__.py +++ b/pyaptamer/datasets/loader/__init__.py @@ -1,6 +1,6 @@ """Loaders for different data structures.""" +from pyaptamer.datasets.loader.a import load_1ghn_structure from pyaptamer.datasets.loader.pfoa_loader import load_pfoa_structure -from pyaptamer.datasets.loader.three_eiy_loader import load_3eiy_structure -__all__ = ["load_pfoa_structure", "load_3eiy_structure"] +__all__ = ["load_pfoa_structure", "load_1ghn_structure"] diff --git a/pyaptamer/datasets/loader/three_eiy_loader.py b/pyaptamer/datasets/loader/a.py similarity index 66% rename from pyaptamer/datasets/loader/three_eiy_loader.py rename to pyaptamer/datasets/loader/a.py index a38c620c..e83a542e 100644 --- a/pyaptamer/datasets/loader/three_eiy_loader.py +++ b/pyaptamer/datasets/loader/a.py @@ -3,23 +3,23 @@ from Bio.PDB import PDBParser -def load_3eiy_structure(pdb_path=None): +def load_1ghn_structure(pdb_path=None): """ - Load the 3eiy molecule from a PDB file using Biopython. + Load the 1ghn molecule from a PDB file using Biopython. Parameters ---------- pdb_path : str, optional Path to the PDB file. If not provided, the function uses the default path - located in the '../data/3eiy.pdb' relative to the current file. + located in the '../data/1ghn.pdb' relative to the current file. Returns ------- structure : Bio.PDB.Structure.Structure A Biopython Structure object representing the PFOA molecule. """ - pdb_path = os.path.join(os.path.dirname(__file__), "..", "data", "3eiy.pdb") + pdb_path = os.path.join(os.path.dirname(__file__), "..", "data", "1ghn.pdb") parser = PDBParser(QUIET=True) - structure = parser.get_structure("3eiy", pdb_path) + structure = parser.get_structure("1ghn", pdb_path) return structure diff --git a/pyaptamer/datasets/tests/test_loaders.py b/pyaptamer/datasets/tests/test_loaders.py index c466fd27..405a3ec8 100644 --- a/pyaptamer/datasets/tests/test_loaders.py +++ b/pyaptamer/datasets/tests/test_loaders.py @@ -2,13 +2,13 @@ from Bio.PDB.Structure import Structure from pyaptamer.datasets.loader import ( - load_3eiy_structure, + load_1ghn_structure, load_pfoa_structure, ) LOADERS = [ load_pfoa_structure, - load_3eiy_structure, + load_1ghn_structure, ] diff --git a/x.py b/x.py new file mode 100644 index 00000000..fbd07df5 --- /dev/null +++ b/x.py @@ -0,0 +1,4 @@ +from pyaptamer.datasets.loader import load_pfoa_structure +from pyaptamer.utils.struct_to_aaseq import struct_to_aaseq + +print(struct_to_aaseq(load_pfoa_structure())) From cace4bd9b45194d2ddf54e66c11e88016f600b2b Mon Sep 17 00:00:00 2001 From: satvshr Date: Wed, 30 Jul 2025 18:39:03 +0530 Subject: [PATCH 064/145] Adds 1ghn instead of 3eiy --- pyaptamer/datasets/loader/__init__.py | 2 +- pyaptamer/datasets/loader/{a.py => one_ghn.py} | 0 x.py | 4 ---- 3 files changed, 1 insertion(+), 5 deletions(-) rename pyaptamer/datasets/loader/{a.py => one_ghn.py} (100%) delete mode 100644 x.py diff --git a/pyaptamer/datasets/loader/__init__.py b/pyaptamer/datasets/loader/__init__.py index 1fc3252a..889c6720 100644 --- a/pyaptamer/datasets/loader/__init__.py +++ b/pyaptamer/datasets/loader/__init__.py @@ -1,6 +1,6 @@ """Loaders for different data structures.""" -from pyaptamer.datasets.loader.a import load_1ghn_structure +from pyaptamer.datasets.loader.one_ghn import load_1ghn_structure from pyaptamer.datasets.loader.pfoa_loader import load_pfoa_structure __all__ = ["load_pfoa_structure", "load_1ghn_structure"] diff --git a/pyaptamer/datasets/loader/a.py b/pyaptamer/datasets/loader/one_ghn.py similarity index 100% rename from pyaptamer/datasets/loader/a.py rename to pyaptamer/datasets/loader/one_ghn.py diff --git a/x.py b/x.py deleted file mode 100644 index fbd07df5..00000000 --- a/x.py +++ /dev/null @@ -1,4 +0,0 @@ -from pyaptamer.datasets.loader import load_pfoa_structure -from pyaptamer.utils.struct_to_aaseq import struct_to_aaseq - -print(struct_to_aaseq(load_pfoa_structure())) From 3301a4c814786b9c66fe3a7bce2cea83c113a8b9 Mon Sep 17 00:00:00 2001 From: satvshr Date: Wed, 30 Jul 2025 18:41:08 +0530 Subject: [PATCH 065/145] Renamed ghn to gnh --- pyaptamer/datasets/loader/__init__.py | 4 ++-- pyaptamer/datasets/loader/{one_ghn.py => one_gnh.py} | 10 +++++----- pyaptamer/datasets/tests/test_loaders.py | 4 ++-- 3 files changed, 9 insertions(+), 9 deletions(-) rename pyaptamer/datasets/loader/{one_ghn.py => one_gnh.py} (66%) diff --git a/pyaptamer/datasets/loader/__init__.py b/pyaptamer/datasets/loader/__init__.py index 889c6720..c9c91fab 100644 --- a/pyaptamer/datasets/loader/__init__.py +++ b/pyaptamer/datasets/loader/__init__.py @@ -1,6 +1,6 @@ """Loaders for different data structures.""" -from pyaptamer.datasets.loader.one_ghn import load_1ghn_structure +from pyaptamer.datasets.loader.one_gnh import load_1gnh_structure from pyaptamer.datasets.loader.pfoa_loader import load_pfoa_structure -__all__ = ["load_pfoa_structure", "load_1ghn_structure"] +__all__ = ["load_pfoa_structure", "load_1gnh_structure"] diff --git a/pyaptamer/datasets/loader/one_ghn.py b/pyaptamer/datasets/loader/one_gnh.py similarity index 66% rename from pyaptamer/datasets/loader/one_ghn.py rename to pyaptamer/datasets/loader/one_gnh.py index e83a542e..bdddb796 100644 --- a/pyaptamer/datasets/loader/one_ghn.py +++ b/pyaptamer/datasets/loader/one_gnh.py @@ -3,23 +3,23 @@ from Bio.PDB import PDBParser -def load_1ghn_structure(pdb_path=None): +def load_1gnh_structure(pdb_path=None): """ - Load the 1ghn molecule from a PDB file using Biopython. + Load the 1gnh molecule from a PDB file using Biopython. Parameters ---------- pdb_path : str, optional Path to the PDB file. If not provided, the function uses the default path - located in the '../data/1ghn.pdb' relative to the current file. + located in the '../data/1gnh.pdb' relative to the current file. Returns ------- structure : Bio.PDB.Structure.Structure A Biopython Structure object representing the PFOA molecule. """ - pdb_path = os.path.join(os.path.dirname(__file__), "..", "data", "1ghn.pdb") + pdb_path = os.path.join(os.path.dirname(__file__), "..", "data", "1gnh.pdb") parser = PDBParser(QUIET=True) - structure = parser.get_structure("1ghn", pdb_path) + structure = parser.get_structure("1gnh", pdb_path) return structure diff --git a/pyaptamer/datasets/tests/test_loaders.py b/pyaptamer/datasets/tests/test_loaders.py index 405a3ec8..51a4c43d 100644 --- a/pyaptamer/datasets/tests/test_loaders.py +++ b/pyaptamer/datasets/tests/test_loaders.py @@ -2,13 +2,13 @@ from Bio.PDB.Structure import Structure from pyaptamer.datasets.loader import ( - load_1ghn_structure, + load_1gnh_structure, load_pfoa_structure, ) LOADERS = [ load_pfoa_structure, - load_1ghn_structure, + load_1gnh_structure, ] From 28de2a30c00cb40bc3d895df4a53d23e8c739cce Mon Sep 17 00:00:00 2001 From: satvshr Date: Wed, 30 Jul 2025 19:29:49 +0530 Subject: [PATCH 066/145] Used 1gnh in tests instead of pfoa since pfoa is not a protein --- pyaptamer/utils/tests/test_struct_to_aaseq.py | 22 +++++++++++-------- 1 file changed, 13 insertions(+), 9 deletions(-) diff --git a/pyaptamer/utils/tests/test_struct_to_aaseq.py b/pyaptamer/utils/tests/test_struct_to_aaseq.py index 30457d4f..16a1e021 100644 --- a/pyaptamer/utils/tests/test_struct_to_aaseq.py +++ b/pyaptamer/utils/tests/test_struct_to_aaseq.py @@ -1,16 +1,20 @@ -import pytest - -from pyaptamer.datasets.loader import load_pfoa_structure +from pyaptamer.datasets.loader import load_1gnh_structure from pyaptamer.utils.struct_to_aaseq import struct_to_aaseq -def test_struct_to_aaseq_runs_and_returns_expected_type(): - structure = load_pfoa_structure() +def test_struct_to_aaseq(): + """ + Test that struct_to_aaseq correctly converts a Biopython Structure + into a list of amino‑acid sequences. + + Asserts: + - No exception is raised when calling the function. + - The return value is a list. + - Each element of the list is a string. + """ + structure = load_1gnh_structure() - try: - sequences = struct_to_aaseq(structure) - except Exception as e: - pytest.fail(f"struct_to_aaseq raised an exception: {e}") + sequences = struct_to_aaseq(structure) assert isinstance(sequences, list), "Return value should be a list" for seq in sequences: From c6ccb23dd553ef4caf8bc5a43ee08a5df4726c16 Mon Sep 17 00:00:00 2001 From: satvshr Date: Thu, 31 Jul 2025 01:15:30 +0530 Subject: [PATCH 067/145] Moved utility function from pipeline to utils --- pyaptamer/aptanet/pipeline.py | 47 +--------------------------- pyaptamer/utils/_aptanet_utils.py | 52 ++++++++++++++++++++++++++++--- 2 files changed, 49 insertions(+), 50 deletions(-) diff --git a/pyaptamer/aptanet/pipeline.py b/pyaptamer/aptanet/pipeline.py index 9067f932..c63693ec 100644 --- a/pyaptamer/aptanet/pipeline.py +++ b/pyaptamer/aptanet/pipeline.py @@ -1,55 +1,10 @@ -import numpy as np import torch import torch.optim as optim from sklearn.pipeline import Pipeline from sklearn.preprocessing import FunctionTransformer from pyaptamer.aptanet import FeatureSelector, SkorchAptaNet -from pyaptamer.pseaac import PSeAAC -from pyaptamer.utils._aptanet_utils import generate_kmer_vecs - - -def pairs_to_features(X, k=4, pseaac_kwargs=None): - """ - Convert a list of (aptamer_sequence, protein_sequence) pairs into feature vectors. - - This function generates feature vectors for each (aptamer, protein) pair using: - - k-mer representation of the aptamer sequence - - Pseudo amino acid composition (PSeAAC) representation of the protein sequence - - Parameters - ---------- - X : list of tuple of str - A list where each element is a tuple `(aptamer_sequence, protein_sequence)`. - `aptamer_sequence` should be a string of nucleotides, and `protein_sequence` - should be a string of amino acids. - - k : int, optional - The k-mer size used to generate the k-mer vector from the aptamer sequence. - Default is 4. - - pseaac_kwargs : dict, optional - Optional keyword arguments to pass to the `PSeAAC` transformer. - If not provided, default parameters are used. - - Returns - ------- - np.ndarray - A 2D NumPy array where each row corresponds to the concatenated feature vector - for a given (aptamer, protein) pair. - """ - pseaac_kwargs = {} if pseaac_kwargs is None else pseaac_kwargs - pseaac = PSeAAC(**pseaac_kwargs) - - feats = [] - for aptamer_seq, protein_seq in X: - kmer = generate_kmer_vecs(aptamer_seq, k=k) - pseaac_vec = np.asarray(pseaac.transform(protein_seq)) - feats.append(np.concatenate([kmer, pseaac_vec])) - - # Ensure float32 for PyTorch compatibility - return np.vstack(feats).astype(np.float32) - +from pyaptamer.utils._aptanet_utils import pairs_to_features net = SkorchAptaNet( module__hidden_dim=128, diff --git a/pyaptamer/utils/_aptanet_utils.py b/pyaptamer/utils/_aptanet_utils.py index ea4bbe9f..044dd56e 100644 --- a/pyaptamer/utils/_aptanet_utils.py +++ b/pyaptamer/utils/_aptanet_utils.py @@ -1,4 +1,8 @@ -DNA_BASES = list("ACGT") +from itertools import product + +import numpy as np + +from pyaptamer.pseaac import PSeAAC def generate_kmer_vecs(aptamer_sequence, k=4): @@ -21,9 +25,7 @@ def generate_kmer_vecs(aptamer_sequence, k=4): 1D numpy array of normalized frequency vector for all possible k-mers from length 1 to k. """ - from itertools import product - - import numpy as np + DNA_BASES = list("ACGT") # Generate all possible k-mers from 1 to k all_kmers = [] @@ -49,3 +51,45 @@ def generate_kmer_vecs(aptamer_sequence, k=4): ) return kmer_freq + + +def pairs_to_features(X, k=4, pseaac_kwargs=None): + """ + Convert a list of (aptamer_sequence, protein_sequence) pairs into feature vectors. + + This function generates feature vectors for each (aptamer, protein) pair using: + - k-mer representation of the aptamer sequence + - Pseudo amino acid composition (PSeAAC) representation of the protein sequence + + Parameters + ---------- + X : list of tuple of str + A list where each element is a tuple `(aptamer_sequence, protein_sequence)`. + `aptamer_sequence` should be a string of nucleotides, and `protein_sequence` + should be a string of amino acids. + + k : int, optional + The k-mer size used to generate the k-mer vector from the aptamer sequence. + Default is 4. + + pseaac_kwargs : dict, optional + Optional keyword arguments to pass to the `PSeAAC` transformer. + If not provided, default parameters are used. + + Returns + ------- + np.ndarray + A 2D NumPy array where each row corresponds to the concatenated feature vector + for a given (aptamer, protein) pair. + """ + pseaac_kwargs = {} if pseaac_kwargs is None else pseaac_kwargs + pseaac = PSeAAC(**pseaac_kwargs) + + feats = [] + for aptamer_seq, protein_seq in X: + kmer = generate_kmer_vecs(aptamer_seq, k=k) + pseaac_vec = np.asarray(pseaac.transform(protein_seq)) + feats.append(np.concatenate([kmer, pseaac_vec])) + + # Ensure float32 for PyTorch compatibility + return np.vstack(feats).astype(np.float32) From e9711c08d9e6d7f0d1158786b19a05f5fceddf15 Mon Sep 17 00:00:00 2001 From: satvshr Date: Thu, 31 Jul 2025 13:37:30 +0530 Subject: [PATCH 068/145] Added pytho ndpendency because of skorch --- pyaptamer/aptanet/skorch.py | 1 + 1 file changed, 1 insertion(+) diff --git a/pyaptamer/aptanet/skorch.py b/pyaptamer/aptanet/skorch.py index c919e9e3..b992c579 100644 --- a/pyaptamer/aptanet/skorch.py +++ b/pyaptamer/aptanet/skorch.py @@ -1,5 +1,6 @@ __author__ = "satvshr" __all__ = ["SkorchAptaNet"] +__required__ = ["python>=3.9,<3.12"] import torch.nn as nn from skorch import NeuralNetBinaryClassifier From 0955226a95d58161401d743e1faed9741a7c6c4b Mon Sep 17 00:00:00 2001 From: satvshr Date: Thu, 31 Jul 2025 13:41:49 +0530 Subject: [PATCH 069/145] Added notebook to examples directory --- aptanet_tutorial.ipynb => examples/aptanet_tutorial.ipynb | 5 +++-- 1 file changed, 3 insertions(+), 2 deletions(-) rename aptanet_tutorial.ipynb => examples/aptanet_tutorial.ipynb (97%) diff --git a/aptanet_tutorial.ipynb b/examples/aptanet_tutorial.ipynb similarity index 97% rename from aptanet_tutorial.ipynb rename to examples/aptanet_tutorial.ipynb index efb65282..7bd67433 100644 --- a/aptanet_tutorial.ipynb +++ b/examples/aptanet_tutorial.ipynb @@ -134,12 +134,13 @@ ], "metadata": { "kernelspec": { - "display_name": "Python 3", + "display_name": "pyaptamer", "language": "python", "name": "python3" }, "language_info": { - "name": "python" + "name": "python", + "version": "3.12.11" } }, "nbformat": 4, From e6e3c9bde52080aa8240036719c4f2543092b503 Mon Sep 17 00:00:00 2001 From: satvshr Date: Thu, 31 Jul 2025 13:52:50 +0530 Subject: [PATCH 070/145] Added first draft of notebook --- examples/aptanet_tutorial.ipynb | 176 +++++++++++++++++++++++++------- 1 file changed, 137 insertions(+), 39 deletions(-) diff --git a/examples/aptanet_tutorial.ipynb b/examples/aptanet_tutorial.ipynb index 7bd67433..ba73e5f3 100644 --- a/examples/aptanet_tutorial.ipynb +++ b/examples/aptanet_tutorial.ipynb @@ -5,7 +5,7 @@ "id": "50e8d179", "metadata": {}, "source": [ - "# AptaNet Tutorial\n", + "# Binding prediction using AptaNet\n", "Step-by-step guide to using AptaNet for binary aptamer–protein binding prediction." ] }, @@ -27,22 +27,73 @@ "metadata": {}, "source": [ "## Imports\n", - "Import the core functions and classes—you don’t need to redefine them." + "Import the core functions and classes." ] }, { "cell_type": "code", - "execution_count": null, + "execution_count": 42, "id": "15eabec8", "metadata": {}, "outputs": [], "source": [ - "import torch\n", + "# General imports\n", + "import torch # noqa: I001\n", "import torch.optim as optim\n", - "from sklearn.pipeline import Pipeline\n", "\n", + "# Data imports\n", + "from pyaptamer.datasets.loader import load_1gnh_structure\n", + "from pyaptamer.utils.struct_to_aaseq import struct_to_aaseq\n", + "\n", + "# If you want to use the aptamer pipeline, you should use the following imports\n", + "from pyaptamer.aptanet.pipeline import pipe\n", + "\n", + "# If you to build your own aptamer pipeline, you should use the following imports\n", + "from sklearn.pipeline import Pipeline\n", "from pyaptamer.aptanet import FeatureSelector, SkorchAptaNet\n", - "from pyaptamer.utils._aptanet_utils import load_pfoa_structure, pairs_to_features" + "from pyaptamer.utils._aptanet_utils import pairs_to_features" + ] + }, + { + "cell_type": "markdown", + "id": "45c592d9", + "metadata": {}, + "source": [ + "## Data preparation\n", + "To train the skorch network the notebook uses:\n", + "* As `X`:\n", + " * 5 random aptamer sequences of length>30 (to satisfy the default lambda value of 30 set in the PSeAAC algorithm).\n", + " * Amino-acid sequences extracted from the 1GNH protein molecule.\n", + "* As `y`:\n", + " * A random binary value (0/1) equal to the number of `(aptamer_seq, protein_seq)` pairs as dummy data." + ] + }, + { + "cell_type": "code", + "execution_count": 43, + "id": "a2f6701d", + "metadata": {}, + "outputs": [], + "source": [ + "aptamer_sequences = [\n", + " \"GGGAGGACGAAGACGACUCGAGACAGGCUAGGGAGGGA\",\n", + " \"AAGCGUCGGAUCUACACGUGCGAUAGCUCAGUACGCGGU\",\n", + " \"CGGUAUCGAGUACAGGAGUCCGACGGAUAGUCCGGAGC\",\n", + " \"UAGCUAGCGAACUAGGCGUAGCUUCGAGUAGCUACGGAA\",\n", + " \"GCUAGGACGAUCGCACGUGACCGUCAGUAGCGUAGGAGA\",\n", + "]\n", + "\n", + "gnh = load_1gnh_structure()\n", + "protein_sequence = struct_to_aaseq(gnh)\n", + "\n", + "unique_proteins = list(set(protein_sequence))\n", + "unique_aptamers = list(set(aptamer_sequences))\n", + "\n", + "# Build all combinations (protein, aptamer)\n", + "X = [(a, p) for a in unique_aptamers for p in unique_proteins]\n", + "\n", + "# Dummy binary labels for the pairs\n", + "y = torch.randint(0, 2, (len(X),))" ] }, { @@ -50,13 +101,34 @@ "id": "cd459190", "metadata": {}, "source": [ - "## Pipeline\n", - "Build a scikit-learn pipeline combining feature extraction, selection, and classification. If you already have a `pipe` defined in your project, you can import and use that instead." + "## Build your own pipeline\n", + " To build a scikit-learn pipeline, follow these steps:\n", + "1. Convert the input to the desired (aptamer_sequence, protein_sequence) format.\n", + " * OPTIONAL: As mentioned in the paper, perform under-sampling using the \n", + " Neighborhood Cleaning Rule to balance the classes.\n", + "2. Get the PSeAAC feature vectors for your converted input (using `pairs_to_features`).\n", + "3. Select the number of features to use from the feature vector (using `FeatureSelector`).\n", + "4. Define the skorch neural network (using `SkorchAptaNet`)." ] }, { "cell_type": "code", - "execution_count": null, + "execution_count": 44, + "id": "0cf0bed1", + "metadata": {}, + "outputs": [], + "source": [ + "# OPTIONAL: If you want to use the Neighborhood Cleaning Rule for under-sampling\n", + "# %pip install imblearn\n", + "# from imblearn.under_sampling import NeighbourhoodCleaningRule\n", + "\n", + "# ncr = NeighbourhoodCleaningRule()\n", + "# X, y = ncr.fit_resample(X, y)" + ] + }, + { + "cell_type": "code", + "execution_count": 45, "id": "13fb1669", "metadata": {}, "outputs": [], @@ -75,8 +147,8 @@ " verbose=1,\n", ")\n", "\n", - "# Option 1: build a new pipeline here\n", - "pipe = Pipeline(\n", + "# Option 1: build a new pipeline\n", + "pipeline = Pipeline(\n", " [\n", " (\"features\", pairs_to_features),\n", " (\"selector\", FeatureSelector()),\n", @@ -84,52 +156,70 @@ " ]\n", ")\n", "\n", - "# Option 2: import the pre-defined pipeline" + "# Option 2: import the pre-defined pipeline (which does the same)\n", + "pipeline = pipe" ] }, { "cell_type": "markdown", - "id": "5ee2f75d", + "id": "4d70138a", "metadata": {}, "source": [ - "## Loading PFOA Structure\n", - "Use the provided loader to get the PFOA structure for visualization or custom feature work:" + "## Model Training and Prediction\n", + "\n", + "Now that we’ve defined our AptaNet pipeline, we proceed to train the model, and use it to predict, on our aptamer-protein dataset." ] }, { "cell_type": "code", - "execution_count": null, - "id": "447b782f", + "execution_count": 46, + "id": "1ed76399", "metadata": {}, - "outputs": [], + "outputs": [ + { + "ename": "ValueError", + "evalue": "n_splits=5 cannot be greater than the number of members in each class.", + "output_type": "error", + "traceback": [ + "\u001b[31m---------------------------------------------------------------------------\u001b[39m", + "\u001b[31mValueError\u001b[39m Traceback (most recent call last)", + 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\u001b[49m\u001b[43m*\u001b[49m\u001b[43m*\u001b[49m\u001b[43mlast_step_params\u001b[49m\u001b[43m[\u001b[49m\u001b[33;43m\"\u001b[39;49m\u001b[33;43mfit\u001b[39;49m\u001b[33;43m\"\u001b[39;49m\u001b[43m]\u001b[49m\u001b[43m)\u001b[49m\n\u001b[32m 665\u001b[39m \u001b[38;5;28;01mreturn\u001b[39;00m \u001b[38;5;28mself\u001b[39m\n", + "\u001b[36mFile \u001b[39m\u001b[32mc:\\Users\\satvm\\miniconda3\\envs\\pyaptamer\\Lib\\site-packages\\skorch\\classifier.py:348\u001b[39m, in \u001b[36mNeuralNetBinaryClassifier.fit\u001b[39m\u001b[34m(self, X, y, **fit_params)\u001b[39m\n\u001b[32m 337\u001b[39m \u001b[38;5;250m\u001b[39m\u001b[33;03m\"\"\"See ``NeuralNet.fit``.\u001b[39;00m\n\u001b[32m 338\u001b[39m \n\u001b[32m 339\u001b[39m \u001b[33;03mIn contrast to ``NeuralNet.fit``, ``y`` is non-optional to\u001b[39;00m\n\u001b[32m (...)\u001b[39m\u001b[32m 343\u001b[39m \n\u001b[32m 344\u001b[39m \u001b[33;03m\"\"\"\u001b[39;00m\n\u001b[32m 345\u001b[39m \u001b[38;5;66;03m# pylint: disable=useless-super-delegation\u001b[39;00m\n\u001b[32m 346\u001b[39m \u001b[38;5;66;03m# this is actually a pylint bug:\u001b[39;00m\n\u001b[32m 347\u001b[39m \u001b[38;5;66;03m# https://github.com/PyCQA/pylint/issues/1085\u001b[39;00m\n\u001b[32m--> \u001b[39m\u001b[32m348\u001b[39m \u001b[38;5;28;01mreturn\u001b[39;00m \u001b[38;5;28;43msuper\u001b[39;49m\u001b[43m(\u001b[49m\u001b[43m)\u001b[49m\u001b[43m.\u001b[49m\u001b[43mfit\u001b[49m\u001b[43m(\u001b[49m\u001b[43mX\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43my\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43m*\u001b[49m\u001b[43m*\u001b[49m\u001b[43mfit_params\u001b[49m\u001b[43m)\u001b[49m\n", + "\u001b[36mFile \u001b[39m\u001b[32mc:\\Users\\satvm\\miniconda3\\envs\\pyaptamer\\Lib\\site-packages\\skorch\\net.py:1349\u001b[39m, in \u001b[36mNeuralNet.fit\u001b[39m\u001b[34m(self, X, y, **fit_params)\u001b[39m\n\u001b[32m 1346\u001b[39m \u001b[38;5;28;01mif\u001b[39;00m \u001b[38;5;129;01mnot\u001b[39;00m \u001b[38;5;28mself\u001b[39m.warm_start \u001b[38;5;129;01mor\u001b[39;00m \u001b[38;5;129;01mnot\u001b[39;00m \u001b[38;5;28mself\u001b[39m.initialized_:\n\u001b[32m 1347\u001b[39m \u001b[38;5;28mself\u001b[39m.initialize()\n\u001b[32m-> \u001b[39m\u001b[32m1349\u001b[39m \u001b[38;5;28;43mself\u001b[39;49m\u001b[43m.\u001b[49m\u001b[43mpartial_fit\u001b[49m\u001b[43m(\u001b[49m\u001b[43mX\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43my\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43m*\u001b[49m\u001b[43m*\u001b[49m\u001b[43mfit_params\u001b[49m\u001b[43m)\u001b[49m\n\u001b[32m 1350\u001b[39m \u001b[38;5;28;01mreturn\u001b[39;00m \u001b[38;5;28mself\u001b[39m\n", + "\u001b[36mFile \u001b[39m\u001b[32mc:\\Users\\satvm\\miniconda3\\envs\\pyaptamer\\Lib\\site-packages\\skorch\\net.py:1308\u001b[39m, in \u001b[36mNeuralNet.partial_fit\u001b[39m\u001b[34m(self, X, y, classes, **fit_params)\u001b[39m\n\u001b[32m 1306\u001b[39m \u001b[38;5;28mself\u001b[39m.notify(\u001b[33m'\u001b[39m\u001b[33mon_train_begin\u001b[39m\u001b[33m'\u001b[39m, X=X, y=y)\n\u001b[32m 1307\u001b[39m \u001b[38;5;28;01mtry\u001b[39;00m:\n\u001b[32m-> \u001b[39m\u001b[32m1308\u001b[39m \u001b[38;5;28;43mself\u001b[39;49m\u001b[43m.\u001b[49m\u001b[43mfit_loop\u001b[49m\u001b[43m(\u001b[49m\u001b[43mX\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43my\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43m*\u001b[49m\u001b[43m*\u001b[49m\u001b[43mfit_params\u001b[49m\u001b[43m)\u001b[49m\n\u001b[32m 1309\u001b[39m \u001b[38;5;28;01mexcept\u001b[39;00m \u001b[38;5;167;01mKeyboardInterrupt\u001b[39;00m:\n\u001b[32m 1310\u001b[39m \u001b[38;5;28;01mpass\u001b[39;00m\n", + "\u001b[36mFile \u001b[39m\u001b[32mc:\\Users\\satvm\\miniconda3\\envs\\pyaptamer\\Lib\\site-packages\\skorch\\net.py:1206\u001b[39m, in \u001b[36mNeuralNet.fit_loop\u001b[39m\u001b[34m(self, X, y, epochs, **fit_params)\u001b[39m\n\u001b[32m 1203\u001b[39m \u001b[38;5;28mself\u001b[39m.check_training_readiness()\n\u001b[32m 1204\u001b[39m epochs = epochs \u001b[38;5;28;01mif\u001b[39;00m epochs \u001b[38;5;129;01mis\u001b[39;00m \u001b[38;5;129;01mnot\u001b[39;00m \u001b[38;5;28;01mNone\u001b[39;00m \u001b[38;5;28;01melse\u001b[39;00m \u001b[38;5;28mself\u001b[39m.max_epochs\n\u001b[32m-> \u001b[39m\u001b[32m1206\u001b[39m dataset_train, dataset_valid = \u001b[38;5;28;43mself\u001b[39;49m\u001b[43m.\u001b[49m\u001b[43mget_split_datasets\u001b[49m\u001b[43m(\u001b[49m\n\u001b[32m 1207\u001b[39m \u001b[43m \u001b[49m\u001b[43mX\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43my\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43m*\u001b[49m\u001b[43m*\u001b[49m\u001b[43mfit_params\u001b[49m\u001b[43m)\u001b[49m\n\u001b[32m 1208\u001b[39m on_epoch_kwargs = {\n\u001b[32m 1209\u001b[39m \u001b[33m'\u001b[39m\u001b[33mdataset_train\u001b[39m\u001b[33m'\u001b[39m: dataset_train,\n\u001b[32m 1210\u001b[39m \u001b[33m'\u001b[39m\u001b[33mdataset_valid\u001b[39m\u001b[33m'\u001b[39m: dataset_valid,\n\u001b[32m 1211\u001b[39m }\n\u001b[32m 1212\u001b[39m iterator_train = \u001b[38;5;28mself\u001b[39m.get_iterator(dataset_train, training=\u001b[38;5;28;01mTrue\u001b[39;00m)\n", + "\u001b[36mFile \u001b[39m\u001b[32mc:\\Users\\satvm\\miniconda3\\envs\\pyaptamer\\Lib\\site-packages\\skorch\\net.py:1801\u001b[39m, in \u001b[36mNeuralNet.get_split_datasets\u001b[39m\u001b[34m(self, X, y, **fit_params)\u001b[39m\n\u001b[32m 1798\u001b[39m \u001b[38;5;28;01mif\u001b[39;00m y \u001b[38;5;129;01mis\u001b[39;00m \u001b[38;5;28;01mNone\u001b[39;00m:\n\u001b[32m 1799\u001b[39m \u001b[38;5;28;01mreturn\u001b[39;00m \u001b[38;5;28mself\u001b[39m.train_split(dataset, **fit_params)\n\u001b[32m-> \u001b[39m\u001b[32m1801\u001b[39m \u001b[38;5;28;01mreturn\u001b[39;00m \u001b[38;5;28;43mself\u001b[39;49m\u001b[43m.\u001b[49m\u001b[43mtrain_split\u001b[49m\u001b[43m(\u001b[49m\u001b[43mdataset\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43my\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43m*\u001b[49m\u001b[43m*\u001b[49m\u001b[43mfit_params\u001b[49m\u001b[43m)\u001b[49m\n", + "\u001b[36mFile \u001b[39m\u001b[32mc:\\Users\\satvm\\miniconda3\\envs\\pyaptamer\\Lib\\site-packages\\skorch\\dataset.py:326\u001b[39m, in \u001b[36mValidSplit.__call__\u001b[39m\u001b[34m(self, dataset, y, groups)\u001b[39m\n\u001b[32m 323\u001b[39m \u001b[38;5;28;01mif\u001b[39;00m \u001b[38;5;28mself\u001b[39m._is_stratified(cv):\n\u001b[32m 324\u001b[39m args = args + (to_numpy(y),)\n\u001b[32m--> \u001b[39m\u001b[32m326\u001b[39m idx_train, idx_valid = \u001b[38;5;28;43mnext\u001b[39;49m\u001b[43m(\u001b[49m\u001b[38;5;28;43miter\u001b[39;49m\u001b[43m(\u001b[49m\u001b[43mcv\u001b[49m\u001b[43m.\u001b[49m\u001b[43msplit\u001b[49m\u001b[43m(\u001b[49m\u001b[43m*\u001b[49m\u001b[43margs\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43mgroups\u001b[49m\u001b[43m=\u001b[49m\u001b[43mgroups\u001b[49m\u001b[43m)\u001b[49m\u001b[43m)\u001b[49m\u001b[43m)\u001b[49m\n\u001b[32m 327\u001b[39m dataset_train = torch.utils.data.Subset(dataset, idx_train)\n\u001b[32m 328\u001b[39m dataset_valid = torch.utils.data.Subset(dataset, idx_valid)\n", + "\u001b[36mFile \u001b[39m\u001b[32mc:\\Users\\satvm\\miniconda3\\envs\\pyaptamer\\Lib\\site-packages\\sklearn\\model_selection\\_split.py:411\u001b[39m, in \u001b[36m_BaseKFold.split\u001b[39m\u001b[34m(self, X, y, groups)\u001b[39m\n\u001b[32m 403\u001b[39m \u001b[38;5;28;01mif\u001b[39;00m \u001b[38;5;28mself\u001b[39m.n_splits > n_samples:\n\u001b[32m 404\u001b[39m \u001b[38;5;28;01mraise\u001b[39;00m \u001b[38;5;167;01mValueError\u001b[39;00m(\n\u001b[32m 405\u001b[39m (\n\u001b[32m 406\u001b[39m \u001b[33m\"\u001b[39m\u001b[33mCannot have number of splits n_splits=\u001b[39m\u001b[38;5;132;01m{0}\u001b[39;00m\u001b[33m greater\u001b[39m\u001b[33m\"\u001b[39m\n\u001b[32m 407\u001b[39m \u001b[33m\"\u001b[39m\u001b[33m than the number of samples: n_samples=\u001b[39m\u001b[38;5;132;01m{1}\u001b[39;00m\u001b[33m.\u001b[39m\u001b[33m\"\u001b[39m\n\u001b[32m 408\u001b[39m ).format(\u001b[38;5;28mself\u001b[39m.n_splits, n_samples)\n\u001b[32m 409\u001b[39m )\n\u001b[32m--> \u001b[39m\u001b[32m411\u001b[39m \u001b[43m\u001b[49m\u001b[38;5;28;43;01mfor\u001b[39;49;00m\u001b[43m \u001b[49m\u001b[43mtrain\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43mtest\u001b[49m\u001b[43m \u001b[49m\u001b[38;5;129;43;01min\u001b[39;49;00m\u001b[43m \u001b[49m\u001b[38;5;28;43msuper\u001b[39;49m\u001b[43m(\u001b[49m\u001b[43m)\u001b[49m\u001b[43m.\u001b[49m\u001b[43msplit\u001b[49m\u001b[43m(\u001b[49m\u001b[43mX\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43my\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43mgroups\u001b[49m\u001b[43m)\u001b[49m\u001b[43m:\u001b[49m\n\u001b[32m 412\u001b[39m \u001b[43m \u001b[49m\u001b[38;5;28;43;01myield\u001b[39;49;00m\u001b[43m \u001b[49m\u001b[43mtrain\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43mtest\u001b[49m\n", + "\u001b[36mFile \u001b[39m\u001b[32mc:\\Users\\satvm\\miniconda3\\envs\\pyaptamer\\Lib\\site-packages\\sklearn\\model_selection\\_split.py:142\u001b[39m, in \u001b[36mBaseCrossValidator.split\u001b[39m\u001b[34m(self, X, y, groups)\u001b[39m\n\u001b[32m 140\u001b[39m X, y, groups = indexable(X, y, groups)\n\u001b[32m 141\u001b[39m indices = np.arange(_num_samples(X))\n\u001b[32m--> \u001b[39m\u001b[32m142\u001b[39m \u001b[43m\u001b[49m\u001b[38;5;28;43;01mfor\u001b[39;49;00m\u001b[43m \u001b[49m\u001b[43mtest_index\u001b[49m\u001b[43m \u001b[49m\u001b[38;5;129;43;01min\u001b[39;49;00m\u001b[43m \u001b[49m\u001b[38;5;28;43mself\u001b[39;49m\u001b[43m.\u001b[49m\u001b[43m_iter_test_masks\u001b[49m\u001b[43m(\u001b[49m\u001b[43mX\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43my\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43mgroups\u001b[49m\u001b[43m)\u001b[49m\u001b[43m:\u001b[49m\n\u001b[32m 143\u001b[39m \u001b[43m \u001b[49m\u001b[43mtrain_index\u001b[49m\u001b[43m \u001b[49m\u001b[43m=\u001b[49m\u001b[43m \u001b[49m\u001b[43mindices\u001b[49m\u001b[43m[\u001b[49m\u001b[43mnp\u001b[49m\u001b[43m.\u001b[49m\u001b[43mlogical_not\u001b[49m\u001b[43m(\u001b[49m\u001b[43mtest_index\u001b[49m\u001b[43m)\u001b[49m\u001b[43m]\u001b[49m\n\u001b[32m 144\u001b[39m \u001b[43m \u001b[49m\u001b[43mtest_index\u001b[49m\u001b[43m \u001b[49m\u001b[43m=\u001b[49m\u001b[43m \u001b[49m\u001b[43mindices\u001b[49m\u001b[43m[\u001b[49m\u001b[43mtest_index\u001b[49m\u001b[43m]\u001b[49m\n", + "\u001b[36mFile \u001b[39m\u001b[32mc:\\Users\\satvm\\miniconda3\\envs\\pyaptamer\\Lib\\site-packages\\sklearn\\model_selection\\_split.py:844\u001b[39m, in \u001b[36mStratifiedKFold._iter_test_masks\u001b[39m\u001b[34m(self, X, y, groups)\u001b[39m\n\u001b[32m 843\u001b[39m \u001b[38;5;28;01mdef\u001b[39;00m\u001b[38;5;250m \u001b[39m\u001b[34m_iter_test_masks\u001b[39m(\u001b[38;5;28mself\u001b[39m, X, y=\u001b[38;5;28;01mNone\u001b[39;00m, groups=\u001b[38;5;28;01mNone\u001b[39;00m):\n\u001b[32m--> \u001b[39m\u001b[32m844\u001b[39m test_folds = \u001b[38;5;28;43mself\u001b[39;49m\u001b[43m.\u001b[49m\u001b[43m_make_test_folds\u001b[49m\u001b[43m(\u001b[49m\u001b[43mX\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43my\u001b[49m\u001b[43m)\u001b[49m\n\u001b[32m 845\u001b[39m \u001b[38;5;28;01mfor\u001b[39;00m i \u001b[38;5;129;01min\u001b[39;00m \u001b[38;5;28mrange\u001b[39m(\u001b[38;5;28mself\u001b[39m.n_splits):\n\u001b[32m 846\u001b[39m \u001b[38;5;28;01myield\u001b[39;00m test_folds == i\n", + "\u001b[36mFile \u001b[39m\u001b[32mc:\\Users\\satvm\\miniconda3\\envs\\pyaptamer\\Lib\\site-packages\\sklearn\\model_selection\\_split.py:806\u001b[39m, in \u001b[36mStratifiedKFold._make_test_folds\u001b[39m\u001b[34m(self, X, y)\u001b[39m\n\u001b[32m 804\u001b[39m min_groups = np.min(y_counts)\n\u001b[32m 805\u001b[39m \u001b[38;5;28;01mif\u001b[39;00m np.all(\u001b[38;5;28mself\u001b[39m.n_splits > y_counts):\n\u001b[32m--> \u001b[39m\u001b[32m806\u001b[39m \u001b[38;5;28;01mraise\u001b[39;00m \u001b[38;5;167;01mValueError\u001b[39;00m(\n\u001b[32m 807\u001b[39m \u001b[33m\"\u001b[39m\u001b[33mn_splits=\u001b[39m\u001b[38;5;132;01m%d\u001b[39;00m\u001b[33m cannot be greater than the\u001b[39m\u001b[33m\"\u001b[39m\n\u001b[32m 808\u001b[39m \u001b[33m\"\u001b[39m\u001b[33m number of members in each class.\u001b[39m\u001b[33m\"\u001b[39m % (\u001b[38;5;28mself\u001b[39m.n_splits)\n\u001b[32m 809\u001b[39m )\n\u001b[32m 810\u001b[39m \u001b[38;5;28;01mif\u001b[39;00m \u001b[38;5;28mself\u001b[39m.n_splits > min_groups:\n\u001b[32m 811\u001b[39m warnings.warn(\n\u001b[32m 812\u001b[39m \u001b[33m\"\u001b[39m\u001b[33mThe least populated class in y has only \u001b[39m\u001b[38;5;132;01m%d\u001b[39;00m\u001b[33m\"\u001b[39m\n\u001b[32m 813\u001b[39m \u001b[33m\"\u001b[39m\u001b[33m members, which is less than n_splits=\u001b[39m\u001b[38;5;132;01m%d\u001b[39;00m\u001b[33m.\u001b[39m\u001b[33m\"\u001b[39m\n\u001b[32m 814\u001b[39m % (min_groups, \u001b[38;5;28mself\u001b[39m.n_splits),\n\u001b[32m 815\u001b[39m \u001b[38;5;167;01mUserWarning\u001b[39;00m,\n\u001b[32m 816\u001b[39m )\n", + "\u001b[31mValueError\u001b[39m: n_splits=5 cannot be greater than the number of members in each class." + ] + } + ], "source": [ - "structure = load_pfoa_structure()\n", - "structure" + "# Fit the pipeline on the aptamer-protein pairs\n", + "pipeline.fit(X, y)\n", + "\n", + "# Predict the labels for the training data\n", + "y_pred = pipeline.predict(X)" ] }, { - "cell_type": "markdown", - "id": "9effcbd1", + "cell_type": "code", + "execution_count": null, + "id": "945dc876", "metadata": {}, + "outputs": [], "source": [ - "## Usage Example\n", - "Once you have your dataset:\n", - "```python\n", - "# X: list of (aptamer_seq, protein_seq)\n", - "# y: binary labels (0/1)\n", - "pipe.fit(X, y)\n", - "preds = pipe.predict(X)\n", - "probs = pipe.predict_proba(X)[:, 1]\n", - "print(classification_report(y, preds))\n", - "print('ROC AUC:', roc_auc_score(y, probs))\n", - "```" + "# Optional: Evaluate training accuracy\n", + "from sklearn.metrics import accuracy_score\n", + "\n", + "print(\"Training Accuracy:\", accuracy_score(y, y_pred))" ] - }, - { - "cell_type": "markdown", - "id": "9eb76d53", - "metadata": {}, - "source": [] } ], "metadata": { @@ -139,7 +229,15 @@ "name": "python3" }, "language_info": { + "codemirror_mode": { + "name": "ipython", + "version": 3 + }, + "file_extension": ".py", + "mimetype": "text/x-python", "name": "python", + "nbconvert_exporter": "python", + "pygments_lexer": "ipython3", "version": "3.12.11" } }, From 727308240d1859984b2199c47ada425b355e9689 Mon Sep 17 00:00:00 2001 From: satvshr Date: Thu, 31 Jul 2025 16:23:51 +0530 Subject: [PATCH 071/145] Logging error --- examples/aptanet_tutorial.ipynb | 28 ++++++++++++++++++---------- 1 file changed, 18 insertions(+), 10 deletions(-) diff --git a/examples/aptanet_tutorial.ipynb b/examples/aptanet_tutorial.ipynb index ba73e5f3..9d919ab2 100644 --- a/examples/aptanet_tutorial.ipynb +++ b/examples/aptanet_tutorial.ipynb @@ -32,7 +32,7 @@ }, { "cell_type": "code", - "execution_count": 42, + "execution_count": 1, "id": "15eabec8", "metadata": {}, "outputs": [], @@ -46,10 +46,10 @@ "from pyaptamer.utils.struct_to_aaseq import struct_to_aaseq\n", "\n", "# If you want to use the aptamer pipeline, you should use the following imports\n", - "from pyaptamer.aptanet.pipeline import pipe\n", "\n", "# If you to build your own aptamer pipeline, you should use the following imports\n", "from sklearn.pipeline import Pipeline\n", + "from sklearn.preprocessing import FunctionTransformer\n", "from pyaptamer.aptanet import FeatureSelector, SkorchAptaNet\n", "from pyaptamer.utils._aptanet_utils import pairs_to_features" ] @@ -70,7 +70,7 @@ }, { "cell_type": "code", - "execution_count": 43, + "execution_count": null, "id": "a2f6701d", "metadata": {}, "outputs": [], @@ -89,7 +89,7 @@ "unique_proteins = list(set(protein_sequence))\n", "unique_aptamers = list(set(aptamer_sequences))\n", "\n", - "# Build all combinations (protein, aptamer)\n", + "# Build all combinations (aptamer, protein)\n", "X = [(a, p) for a in unique_aptamers for p in unique_proteins]\n", "\n", "# Dummy binary labels for the pairs\n", @@ -113,7 +113,7 @@ }, { "cell_type": "code", - "execution_count": 44, + "execution_count": 3, "id": "0cf0bed1", "metadata": {}, "outputs": [], @@ -128,7 +128,7 @@ }, { "cell_type": "code", - "execution_count": 45, + "execution_count": 4, "id": "13fb1669", "metadata": {}, "outputs": [], @@ -147,17 +147,25 @@ " verbose=1,\n", ")\n", "\n", + "feature_transformer = FunctionTransformer(\n", + " func=pairs_to_features,\n", + " validate=False,\n", + " # Optional arguments for pairs_to_features\n", + " # example: kw_args={'k': 4, 'pseaac_kwargs': {'lambda_value': 30}}\n", + " kw_args={},\n", + ")\n", + "\n", "# Option 1: build a new pipeline\n", "pipeline = Pipeline(\n", " [\n", - " (\"features\", pairs_to_features),\n", + " (\"features\", feature_transformer),\n", " (\"selector\", FeatureSelector()),\n", " (\"clf\", net),\n", " ]\n", ")\n", "\n", "# Option 2: import the pre-defined pipeline (which does the same)\n", - "pipeline = pipe" + "# pipeline = pipe" ] }, { @@ -172,7 +180,7 @@ }, { "cell_type": "code", - "execution_count": 46, + "execution_count": 5, "id": "1ed76399", "metadata": {}, "outputs": [ @@ -183,7 +191,7 @@ "traceback": [ "\u001b[31m---------------------------------------------------------------------------\u001b[39m", "\u001b[31mValueError\u001b[39m Traceback (most recent call last)", - "\u001b[36mCell\u001b[39m\u001b[36m \u001b[39m\u001b[32mIn[46]\u001b[39m\u001b[32m, line 2\u001b[39m\n\u001b[32m 1\u001b[39m \u001b[38;5;66;03m# Fit the pipeline on the aptamer-protein pairs\u001b[39;00m\n\u001b[32m----> \u001b[39m\u001b[32m2\u001b[39m \u001b[43mpipeline\u001b[49m\u001b[43m.\u001b[49m\u001b[43mfit\u001b[49m\u001b[43m(\u001b[49m\u001b[43mX\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43my\u001b[49m\u001b[43m)\u001b[49m\n\u001b[32m 4\u001b[39m \u001b[38;5;66;03m# Predict the labels for the training data\u001b[39;00m\n\u001b[32m 5\u001b[39m y_pred = pipeline.predict(X)\n", + "\u001b[36mCell\u001b[39m\u001b[36m \u001b[39m\u001b[32mIn[5]\u001b[39m\u001b[32m, line 2\u001b[39m\n\u001b[32m 1\u001b[39m \u001b[38;5;66;03m# Fit the pipeline on the aptamer-protein pairs\u001b[39;00m\n\u001b[32m----> \u001b[39m\u001b[32m2\u001b[39m \u001b[43mpipeline\u001b[49m\u001b[43m.\u001b[49m\u001b[43mfit\u001b[49m\u001b[43m(\u001b[49m\u001b[43mX\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43my\u001b[49m\u001b[43m)\u001b[49m\n\u001b[32m 4\u001b[39m \u001b[38;5;66;03m# Predict the labels for the training data\u001b[39;00m\n\u001b[32m 5\u001b[39m y_pred = pipeline.predict(X)\n", "\u001b[36mFile \u001b[39m\u001b[32mc:\\Users\\satvm\\miniconda3\\envs\\pyaptamer\\Lib\\site-packages\\sklearn\\base.py:1365\u001b[39m, in \u001b[36m_fit_context..decorator..wrapper\u001b[39m\u001b[34m(estimator, *args, **kwargs)\u001b[39m\n\u001b[32m 1358\u001b[39m estimator._validate_params()\n\u001b[32m 1360\u001b[39m \u001b[38;5;28;01mwith\u001b[39;00m config_context(\n\u001b[32m 1361\u001b[39m skip_parameter_validation=(\n\u001b[32m 1362\u001b[39m prefer_skip_nested_validation \u001b[38;5;129;01mor\u001b[39;00m global_skip_validation\n\u001b[32m 1363\u001b[39m )\n\u001b[32m 1364\u001b[39m ):\n\u001b[32m-> \u001b[39m\u001b[32m1365\u001b[39m \u001b[38;5;28;01mreturn\u001b[39;00m \u001b[43mfit_method\u001b[49m\u001b[43m(\u001b[49m\u001b[43mestimator\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43m*\u001b[49m\u001b[43margs\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43m*\u001b[49m\u001b[43m*\u001b[49m\u001b[43mkwargs\u001b[49m\u001b[43m)\u001b[49m\n", "\u001b[36mFile \u001b[39m\u001b[32mc:\\Users\\satvm\\miniconda3\\envs\\pyaptamer\\Lib\\site-packages\\sklearn\\pipeline.py:663\u001b[39m, in \u001b[36mPipeline.fit\u001b[39m\u001b[34m(self, X, y, **params)\u001b[39m\n\u001b[32m 657\u001b[39m \u001b[38;5;28;01mif\u001b[39;00m \u001b[38;5;28mself\u001b[39m._final_estimator != \u001b[33m\"\u001b[39m\u001b[33mpassthrough\u001b[39m\u001b[33m\"\u001b[39m:\n\u001b[32m 658\u001b[39m last_step_params = \u001b[38;5;28mself\u001b[39m._get_metadata_for_step(\n\u001b[32m 659\u001b[39m step_idx=\u001b[38;5;28mlen\u001b[39m(\u001b[38;5;28mself\u001b[39m) - \u001b[32m1\u001b[39m,\n\u001b[32m 660\u001b[39m step_params=routed_params[\u001b[38;5;28mself\u001b[39m.steps[-\u001b[32m1\u001b[39m][\u001b[32m0\u001b[39m]],\n\u001b[32m 661\u001b[39m all_params=params,\n\u001b[32m 662\u001b[39m )\n\u001b[32m--> \u001b[39m\u001b[32m663\u001b[39m \u001b[38;5;28;43mself\u001b[39;49m\u001b[43m.\u001b[49m\u001b[43m_final_estimator\u001b[49m\u001b[43m.\u001b[49m\u001b[43mfit\u001b[49m\u001b[43m(\u001b[49m\u001b[43mXt\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43my\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43m*\u001b[49m\u001b[43m*\u001b[49m\u001b[43mlast_step_params\u001b[49m\u001b[43m[\u001b[49m\u001b[33;43m\"\u001b[39;49m\u001b[33;43mfit\u001b[39;49m\u001b[33;43m\"\u001b[39;49m\u001b[43m]\u001b[49m\u001b[43m)\u001b[49m\n\u001b[32m 665\u001b[39m \u001b[38;5;28;01mreturn\u001b[39;00m \u001b[38;5;28mself\u001b[39m\n", "\u001b[36mFile \u001b[39m\u001b[32mc:\\Users\\satvm\\miniconda3\\envs\\pyaptamer\\Lib\\site-packages\\skorch\\classifier.py:348\u001b[39m, in \u001b[36mNeuralNetBinaryClassifier.fit\u001b[39m\u001b[34m(self, X, y, **fit_params)\u001b[39m\n\u001b[32m 337\u001b[39m \u001b[38;5;250m\u001b[39m\u001b[33;03m\"\"\"See ``NeuralNet.fit``.\u001b[39;00m\n\u001b[32m 338\u001b[39m \n\u001b[32m 339\u001b[39m \u001b[33;03mIn contrast to ``NeuralNet.fit``, ``y`` is non-optional to\u001b[39;00m\n\u001b[32m (...)\u001b[39m\u001b[32m 343\u001b[39m \n\u001b[32m 344\u001b[39m \u001b[33;03m\"\"\"\u001b[39;00m\n\u001b[32m 345\u001b[39m \u001b[38;5;66;03m# pylint: disable=useless-super-delegation\u001b[39;00m\n\u001b[32m 346\u001b[39m \u001b[38;5;66;03m# this is actually a pylint bug:\u001b[39;00m\n\u001b[32m 347\u001b[39m \u001b[38;5;66;03m# https://github.com/PyCQA/pylint/issues/1085\u001b[39;00m\n\u001b[32m--> \u001b[39m\u001b[32m348\u001b[39m \u001b[38;5;28;01mreturn\u001b[39;00m \u001b[38;5;28;43msuper\u001b[39;49m\u001b[43m(\u001b[49m\u001b[43m)\u001b[49m\u001b[43m.\u001b[49m\u001b[43mfit\u001b[49m\u001b[43m(\u001b[49m\u001b[43mX\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43my\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43m*\u001b[49m\u001b[43m*\u001b[49m\u001b[43mfit_params\u001b[49m\u001b[43m)\u001b[49m\n", From ad8db593f1885c479291a4d340902be14ca5d490 Mon Sep 17 00:00:00 2001 From: satvshr Date: Thu, 31 Jul 2025 16:40:23 +0530 Subject: [PATCH 072/145] Fixed bug during fit --- examples/aptanet_tutorial.ipynb | 250 ++++++++++++++++++++++++++++---- 1 file changed, 222 insertions(+), 28 deletions(-) diff --git a/examples/aptanet_tutorial.ipynb b/examples/aptanet_tutorial.ipynb index 9d919ab2..763245f3 100644 --- a/examples/aptanet_tutorial.ipynb +++ b/examples/aptanet_tutorial.ipynb @@ -32,7 +32,7 @@ }, { "cell_type": "code", - "execution_count": 1, + "execution_count": 14, "id": "15eabec8", "metadata": {}, "outputs": [], @@ -70,7 +70,7 @@ }, { "cell_type": "code", - "execution_count": null, + "execution_count": 15, "id": "a2f6701d", "metadata": {}, "outputs": [], @@ -93,7 +93,7 @@ "X = [(a, p) for a in unique_aptamers for p in unique_proteins]\n", "\n", "# Dummy binary labels for the pairs\n", - "y = torch.randint(0, 2, (len(X),))" + "y = torch.randint(0, 2, (len(X),), dtype=torch.float32)" ] }, { @@ -113,7 +113,7 @@ }, { "cell_type": "code", - "execution_count": 3, + "execution_count": 16, "id": "0cf0bed1", "metadata": {}, "outputs": [], @@ -128,7 +128,7 @@ }, { "cell_type": "code", - "execution_count": 4, + "execution_count": 17, "id": "13fb1669", "metadata": {}, "outputs": [], @@ -144,6 +144,7 @@ " optimizer=optim.RMSprop,\n", " device=\"cuda\" if torch.cuda.is_available() else \"cpu\",\n", " threshold=0.5,\n", + " train_split=None,\n", " verbose=1,\n", ")\n", "\n", @@ -180,31 +181,216 @@ }, { "cell_type": "code", - "execution_count": 5, + "execution_count": 18, "id": "1ed76399", "metadata": {}, "outputs": [ { - "ename": "ValueError", - "evalue": "n_splits=5 cannot be greater than the number of members in each class.", - "output_type": "error", - "traceback": [ - "\u001b[31m---------------------------------------------------------------------------\u001b[39m", - "\u001b[31mValueError\u001b[39m Traceback (most recent call last)", - "\u001b[36mCell\u001b[39m\u001b[36m \u001b[39m\u001b[32mIn[5]\u001b[39m\u001b[32m, line 2\u001b[39m\n\u001b[32m 1\u001b[39m \u001b[38;5;66;03m# Fit the pipeline on the aptamer-protein pairs\u001b[39;00m\n\u001b[32m----> \u001b[39m\u001b[32m2\u001b[39m \u001b[43mpipeline\u001b[49m\u001b[43m.\u001b[49m\u001b[43mfit\u001b[49m\u001b[43m(\u001b[49m\u001b[43mX\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43my\u001b[49m\u001b[43m)\u001b[49m\n\u001b[32m 4\u001b[39m \u001b[38;5;66;03m# Predict the labels for the training data\u001b[39;00m\n\u001b[32m 5\u001b[39m y_pred = pipeline.predict(X)\n", - "\u001b[36mFile \u001b[39m\u001b[32mc:\\Users\\satvm\\miniconda3\\envs\\pyaptamer\\Lib\\site-packages\\sklearn\\base.py:1365\u001b[39m, in \u001b[36m_fit_context..decorator..wrapper\u001b[39m\u001b[34m(estimator, *args, **kwargs)\u001b[39m\n\u001b[32m 1358\u001b[39m estimator._validate_params()\n\u001b[32m 1360\u001b[39m \u001b[38;5;28;01mwith\u001b[39;00m config_context(\n\u001b[32m 1361\u001b[39m skip_parameter_validation=(\n\u001b[32m 1362\u001b[39m prefer_skip_nested_validation \u001b[38;5;129;01mor\u001b[39;00m global_skip_validation\n\u001b[32m 1363\u001b[39m )\n\u001b[32m 1364\u001b[39m ):\n\u001b[32m-> \u001b[39m\u001b[32m1365\u001b[39m \u001b[38;5;28;01mreturn\u001b[39;00m \u001b[43mfit_method\u001b[49m\u001b[43m(\u001b[49m\u001b[43mestimator\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43m*\u001b[49m\u001b[43margs\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43m*\u001b[49m\u001b[43m*\u001b[49m\u001b[43mkwargs\u001b[49m\u001b[43m)\u001b[49m\n", - "\u001b[36mFile \u001b[39m\u001b[32mc:\\Users\\satvm\\miniconda3\\envs\\pyaptamer\\Lib\\site-packages\\sklearn\\pipeline.py:663\u001b[39m, in \u001b[36mPipeline.fit\u001b[39m\u001b[34m(self, X, y, **params)\u001b[39m\n\u001b[32m 657\u001b[39m \u001b[38;5;28;01mif\u001b[39;00m \u001b[38;5;28mself\u001b[39m._final_estimator != \u001b[33m\"\u001b[39m\u001b[33mpassthrough\u001b[39m\u001b[33m\"\u001b[39m:\n\u001b[32m 658\u001b[39m last_step_params = \u001b[38;5;28mself\u001b[39m._get_metadata_for_step(\n\u001b[32m 659\u001b[39m step_idx=\u001b[38;5;28mlen\u001b[39m(\u001b[38;5;28mself\u001b[39m) - \u001b[32m1\u001b[39m,\n\u001b[32m 660\u001b[39m step_params=routed_params[\u001b[38;5;28mself\u001b[39m.steps[-\u001b[32m1\u001b[39m][\u001b[32m0\u001b[39m]],\n\u001b[32m 661\u001b[39m all_params=params,\n\u001b[32m 662\u001b[39m )\n\u001b[32m--> \u001b[39m\u001b[32m663\u001b[39m \u001b[38;5;28;43mself\u001b[39;49m\u001b[43m.\u001b[49m\u001b[43m_final_estimator\u001b[49m\u001b[43m.\u001b[49m\u001b[43mfit\u001b[49m\u001b[43m(\u001b[49m\u001b[43mXt\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43my\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43m*\u001b[49m\u001b[43m*\u001b[49m\u001b[43mlast_step_params\u001b[49m\u001b[43m[\u001b[49m\u001b[33;43m\"\u001b[39;49m\u001b[33;43mfit\u001b[39;49m\u001b[33;43m\"\u001b[39;49m\u001b[43m]\u001b[49m\u001b[43m)\u001b[49m\n\u001b[32m 665\u001b[39m \u001b[38;5;28;01mreturn\u001b[39;00m \u001b[38;5;28mself\u001b[39m\n", - "\u001b[36mFile \u001b[39m\u001b[32mc:\\Users\\satvm\\miniconda3\\envs\\pyaptamer\\Lib\\site-packages\\skorch\\classifier.py:348\u001b[39m, in \u001b[36mNeuralNetBinaryClassifier.fit\u001b[39m\u001b[34m(self, X, y, **fit_params)\u001b[39m\n\u001b[32m 337\u001b[39m \u001b[38;5;250m\u001b[39m\u001b[33;03m\"\"\"See ``NeuralNet.fit``.\u001b[39;00m\n\u001b[32m 338\u001b[39m \n\u001b[32m 339\u001b[39m \u001b[33;03mIn contrast to ``NeuralNet.fit``, ``y`` is non-optional to\u001b[39;00m\n\u001b[32m (...)\u001b[39m\u001b[32m 343\u001b[39m \n\u001b[32m 344\u001b[39m \u001b[33;03m\"\"\"\u001b[39;00m\n\u001b[32m 345\u001b[39m \u001b[38;5;66;03m# pylint: disable=useless-super-delegation\u001b[39;00m\n\u001b[32m 346\u001b[39m \u001b[38;5;66;03m# this is actually a pylint bug:\u001b[39;00m\n\u001b[32m 347\u001b[39m \u001b[38;5;66;03m# https://github.com/PyCQA/pylint/issues/1085\u001b[39;00m\n\u001b[32m--> \u001b[39m\u001b[32m348\u001b[39m \u001b[38;5;28;01mreturn\u001b[39;00m \u001b[38;5;28;43msuper\u001b[39;49m\u001b[43m(\u001b[49m\u001b[43m)\u001b[49m\u001b[43m.\u001b[49m\u001b[43mfit\u001b[49m\u001b[43m(\u001b[49m\u001b[43mX\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43my\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43m*\u001b[49m\u001b[43m*\u001b[49m\u001b[43mfit_params\u001b[49m\u001b[43m)\u001b[49m\n", - "\u001b[36mFile \u001b[39m\u001b[32mc:\\Users\\satvm\\miniconda3\\envs\\pyaptamer\\Lib\\site-packages\\skorch\\net.py:1349\u001b[39m, in \u001b[36mNeuralNet.fit\u001b[39m\u001b[34m(self, X, y, **fit_params)\u001b[39m\n\u001b[32m 1346\u001b[39m \u001b[38;5;28;01mif\u001b[39;00m \u001b[38;5;129;01mnot\u001b[39;00m \u001b[38;5;28mself\u001b[39m.warm_start \u001b[38;5;129;01mor\u001b[39;00m \u001b[38;5;129;01mnot\u001b[39;00m \u001b[38;5;28mself\u001b[39m.initialized_:\n\u001b[32m 1347\u001b[39m \u001b[38;5;28mself\u001b[39m.initialize()\n\u001b[32m-> \u001b[39m\u001b[32m1349\u001b[39m \u001b[38;5;28;43mself\u001b[39;49m\u001b[43m.\u001b[49m\u001b[43mpartial_fit\u001b[49m\u001b[43m(\u001b[49m\u001b[43mX\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43my\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43m*\u001b[49m\u001b[43m*\u001b[49m\u001b[43mfit_params\u001b[49m\u001b[43m)\u001b[49m\n\u001b[32m 1350\u001b[39m \u001b[38;5;28;01mreturn\u001b[39;00m \u001b[38;5;28mself\u001b[39m\n", - "\u001b[36mFile \u001b[39m\u001b[32mc:\\Users\\satvm\\miniconda3\\envs\\pyaptamer\\Lib\\site-packages\\skorch\\net.py:1308\u001b[39m, in \u001b[36mNeuralNet.partial_fit\u001b[39m\u001b[34m(self, X, y, classes, **fit_params)\u001b[39m\n\u001b[32m 1306\u001b[39m \u001b[38;5;28mself\u001b[39m.notify(\u001b[33m'\u001b[39m\u001b[33mon_train_begin\u001b[39m\u001b[33m'\u001b[39m, X=X, y=y)\n\u001b[32m 1307\u001b[39m \u001b[38;5;28;01mtry\u001b[39;00m:\n\u001b[32m-> \u001b[39m\u001b[32m1308\u001b[39m \u001b[38;5;28;43mself\u001b[39;49m\u001b[43m.\u001b[49m\u001b[43mfit_loop\u001b[49m\u001b[43m(\u001b[49m\u001b[43mX\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43my\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43m*\u001b[49m\u001b[43m*\u001b[49m\u001b[43mfit_params\u001b[49m\u001b[43m)\u001b[49m\n\u001b[32m 1309\u001b[39m \u001b[38;5;28;01mexcept\u001b[39;00m \u001b[38;5;167;01mKeyboardInterrupt\u001b[39;00m:\n\u001b[32m 1310\u001b[39m \u001b[38;5;28;01mpass\u001b[39;00m\n", - "\u001b[36mFile \u001b[39m\u001b[32mc:\\Users\\satvm\\miniconda3\\envs\\pyaptamer\\Lib\\site-packages\\skorch\\net.py:1206\u001b[39m, in \u001b[36mNeuralNet.fit_loop\u001b[39m\u001b[34m(self, X, y, epochs, **fit_params)\u001b[39m\n\u001b[32m 1203\u001b[39m \u001b[38;5;28mself\u001b[39m.check_training_readiness()\n\u001b[32m 1204\u001b[39m epochs = epochs \u001b[38;5;28;01mif\u001b[39;00m epochs \u001b[38;5;129;01mis\u001b[39;00m \u001b[38;5;129;01mnot\u001b[39;00m \u001b[38;5;28;01mNone\u001b[39;00m \u001b[38;5;28;01melse\u001b[39;00m \u001b[38;5;28mself\u001b[39m.max_epochs\n\u001b[32m-> \u001b[39m\u001b[32m1206\u001b[39m dataset_train, dataset_valid = \u001b[38;5;28;43mself\u001b[39;49m\u001b[43m.\u001b[49m\u001b[43mget_split_datasets\u001b[49m\u001b[43m(\u001b[49m\n\u001b[32m 1207\u001b[39m \u001b[43m \u001b[49m\u001b[43mX\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43my\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43m*\u001b[49m\u001b[43m*\u001b[49m\u001b[43mfit_params\u001b[49m\u001b[43m)\u001b[49m\n\u001b[32m 1208\u001b[39m on_epoch_kwargs = {\n\u001b[32m 1209\u001b[39m \u001b[33m'\u001b[39m\u001b[33mdataset_train\u001b[39m\u001b[33m'\u001b[39m: dataset_train,\n\u001b[32m 1210\u001b[39m \u001b[33m'\u001b[39m\u001b[33mdataset_valid\u001b[39m\u001b[33m'\u001b[39m: dataset_valid,\n\u001b[32m 1211\u001b[39m }\n\u001b[32m 1212\u001b[39m iterator_train = \u001b[38;5;28mself\u001b[39m.get_iterator(dataset_train, training=\u001b[38;5;28;01mTrue\u001b[39;00m)\n", - "\u001b[36mFile \u001b[39m\u001b[32mc:\\Users\\satvm\\miniconda3\\envs\\pyaptamer\\Lib\\site-packages\\skorch\\net.py:1801\u001b[39m, in \u001b[36mNeuralNet.get_split_datasets\u001b[39m\u001b[34m(self, X, y, **fit_params)\u001b[39m\n\u001b[32m 1798\u001b[39m \u001b[38;5;28;01mif\u001b[39;00m y \u001b[38;5;129;01mis\u001b[39;00m \u001b[38;5;28;01mNone\u001b[39;00m:\n\u001b[32m 1799\u001b[39m \u001b[38;5;28;01mreturn\u001b[39;00m \u001b[38;5;28mself\u001b[39m.train_split(dataset, **fit_params)\n\u001b[32m-> \u001b[39m\u001b[32m1801\u001b[39m \u001b[38;5;28;01mreturn\u001b[39;00m \u001b[38;5;28;43mself\u001b[39;49m\u001b[43m.\u001b[49m\u001b[43mtrain_split\u001b[49m\u001b[43m(\u001b[49m\u001b[43mdataset\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43my\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43m*\u001b[49m\u001b[43m*\u001b[49m\u001b[43mfit_params\u001b[49m\u001b[43m)\u001b[49m\n", - "\u001b[36mFile \u001b[39m\u001b[32mc:\\Users\\satvm\\miniconda3\\envs\\pyaptamer\\Lib\\site-packages\\skorch\\dataset.py:326\u001b[39m, in \u001b[36mValidSplit.__call__\u001b[39m\u001b[34m(self, dataset, y, groups)\u001b[39m\n\u001b[32m 323\u001b[39m \u001b[38;5;28;01mif\u001b[39;00m \u001b[38;5;28mself\u001b[39m._is_stratified(cv):\n\u001b[32m 324\u001b[39m args = args + (to_numpy(y),)\n\u001b[32m--> \u001b[39m\u001b[32m326\u001b[39m idx_train, idx_valid = \u001b[38;5;28;43mnext\u001b[39;49m\u001b[43m(\u001b[49m\u001b[38;5;28;43miter\u001b[39;49m\u001b[43m(\u001b[49m\u001b[43mcv\u001b[49m\u001b[43m.\u001b[49m\u001b[43msplit\u001b[49m\u001b[43m(\u001b[49m\u001b[43m*\u001b[49m\u001b[43margs\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43mgroups\u001b[49m\u001b[43m=\u001b[49m\u001b[43mgroups\u001b[49m\u001b[43m)\u001b[49m\u001b[43m)\u001b[49m\u001b[43m)\u001b[49m\n\u001b[32m 327\u001b[39m dataset_train = torch.utils.data.Subset(dataset, idx_train)\n\u001b[32m 328\u001b[39m dataset_valid = torch.utils.data.Subset(dataset, idx_valid)\n", - "\u001b[36mFile \u001b[39m\u001b[32mc:\\Users\\satvm\\miniconda3\\envs\\pyaptamer\\Lib\\site-packages\\sklearn\\model_selection\\_split.py:411\u001b[39m, in \u001b[36m_BaseKFold.split\u001b[39m\u001b[34m(self, X, y, groups)\u001b[39m\n\u001b[32m 403\u001b[39m \u001b[38;5;28;01mif\u001b[39;00m \u001b[38;5;28mself\u001b[39m.n_splits > n_samples:\n\u001b[32m 404\u001b[39m \u001b[38;5;28;01mraise\u001b[39;00m \u001b[38;5;167;01mValueError\u001b[39;00m(\n\u001b[32m 405\u001b[39m (\n\u001b[32m 406\u001b[39m \u001b[33m\"\u001b[39m\u001b[33mCannot have number of splits n_splits=\u001b[39m\u001b[38;5;132;01m{0}\u001b[39;00m\u001b[33m greater\u001b[39m\u001b[33m\"\u001b[39m\n\u001b[32m 407\u001b[39m \u001b[33m\"\u001b[39m\u001b[33m than the number of samples: n_samples=\u001b[39m\u001b[38;5;132;01m{1}\u001b[39;00m\u001b[33m.\u001b[39m\u001b[33m\"\u001b[39m\n\u001b[32m 408\u001b[39m ).format(\u001b[38;5;28mself\u001b[39m.n_splits, n_samples)\n\u001b[32m 409\u001b[39m )\n\u001b[32m--> \u001b[39m\u001b[32m411\u001b[39m \u001b[43m\u001b[49m\u001b[38;5;28;43;01mfor\u001b[39;49;00m\u001b[43m \u001b[49m\u001b[43mtrain\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43mtest\u001b[49m\u001b[43m \u001b[49m\u001b[38;5;129;43;01min\u001b[39;49;00m\u001b[43m \u001b[49m\u001b[38;5;28;43msuper\u001b[39;49m\u001b[43m(\u001b[49m\u001b[43m)\u001b[49m\u001b[43m.\u001b[49m\u001b[43msplit\u001b[49m\u001b[43m(\u001b[49m\u001b[43mX\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43my\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43mgroups\u001b[49m\u001b[43m)\u001b[49m\u001b[43m:\u001b[49m\n\u001b[32m 412\u001b[39m \u001b[43m \u001b[49m\u001b[38;5;28;43;01myield\u001b[39;49;00m\u001b[43m \u001b[49m\u001b[43mtrain\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43mtest\u001b[49m\n", - "\u001b[36mFile \u001b[39m\u001b[32mc:\\Users\\satvm\\miniconda3\\envs\\pyaptamer\\Lib\\site-packages\\sklearn\\model_selection\\_split.py:142\u001b[39m, in \u001b[36mBaseCrossValidator.split\u001b[39m\u001b[34m(self, X, y, groups)\u001b[39m\n\u001b[32m 140\u001b[39m X, y, groups = indexable(X, y, groups)\n\u001b[32m 141\u001b[39m indices = np.arange(_num_samples(X))\n\u001b[32m--> \u001b[39m\u001b[32m142\u001b[39m \u001b[43m\u001b[49m\u001b[38;5;28;43;01mfor\u001b[39;49;00m\u001b[43m \u001b[49m\u001b[43mtest_index\u001b[49m\u001b[43m \u001b[49m\u001b[38;5;129;43;01min\u001b[39;49;00m\u001b[43m \u001b[49m\u001b[38;5;28;43mself\u001b[39;49m\u001b[43m.\u001b[49m\u001b[43m_iter_test_masks\u001b[49m\u001b[43m(\u001b[49m\u001b[43mX\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43my\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43mgroups\u001b[49m\u001b[43m)\u001b[49m\u001b[43m:\u001b[49m\n\u001b[32m 143\u001b[39m \u001b[43m \u001b[49m\u001b[43mtrain_index\u001b[49m\u001b[43m \u001b[49m\u001b[43m=\u001b[49m\u001b[43m \u001b[49m\u001b[43mindices\u001b[49m\u001b[43m[\u001b[49m\u001b[43mnp\u001b[49m\u001b[43m.\u001b[49m\u001b[43mlogical_not\u001b[49m\u001b[43m(\u001b[49m\u001b[43mtest_index\u001b[49m\u001b[43m)\u001b[49m\u001b[43m]\u001b[49m\n\u001b[32m 144\u001b[39m \u001b[43m \u001b[49m\u001b[43mtest_index\u001b[49m\u001b[43m \u001b[49m\u001b[43m=\u001b[49m\u001b[43m \u001b[49m\u001b[43mindices\u001b[49m\u001b[43m[\u001b[49m\u001b[43mtest_index\u001b[49m\u001b[43m]\u001b[49m\n", - "\u001b[36mFile \u001b[39m\u001b[32mc:\\Users\\satvm\\miniconda3\\envs\\pyaptamer\\Lib\\site-packages\\sklearn\\model_selection\\_split.py:844\u001b[39m, in \u001b[36mStratifiedKFold._iter_test_masks\u001b[39m\u001b[34m(self, X, y, groups)\u001b[39m\n\u001b[32m 843\u001b[39m \u001b[38;5;28;01mdef\u001b[39;00m\u001b[38;5;250m \u001b[39m\u001b[34m_iter_test_masks\u001b[39m(\u001b[38;5;28mself\u001b[39m, X, y=\u001b[38;5;28;01mNone\u001b[39;00m, groups=\u001b[38;5;28;01mNone\u001b[39;00m):\n\u001b[32m--> \u001b[39m\u001b[32m844\u001b[39m test_folds = \u001b[38;5;28;43mself\u001b[39;49m\u001b[43m.\u001b[49m\u001b[43m_make_test_folds\u001b[49m\u001b[43m(\u001b[49m\u001b[43mX\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43my\u001b[49m\u001b[43m)\u001b[49m\n\u001b[32m 845\u001b[39m \u001b[38;5;28;01mfor\u001b[39;00m i \u001b[38;5;129;01min\u001b[39;00m \u001b[38;5;28mrange\u001b[39m(\u001b[38;5;28mself\u001b[39m.n_splits):\n\u001b[32m 846\u001b[39m \u001b[38;5;28;01myield\u001b[39;00m test_folds == i\n", - "\u001b[36mFile \u001b[39m\u001b[32mc:\\Users\\satvm\\miniconda3\\envs\\pyaptamer\\Lib\\site-packages\\sklearn\\model_selection\\_split.py:806\u001b[39m, in \u001b[36mStratifiedKFold._make_test_folds\u001b[39m\u001b[34m(self, X, y)\u001b[39m\n\u001b[32m 804\u001b[39m min_groups = np.min(y_counts)\n\u001b[32m 805\u001b[39m \u001b[38;5;28;01mif\u001b[39;00m np.all(\u001b[38;5;28mself\u001b[39m.n_splits > y_counts):\n\u001b[32m--> \u001b[39m\u001b[32m806\u001b[39m \u001b[38;5;28;01mraise\u001b[39;00m \u001b[38;5;167;01mValueError\u001b[39;00m(\n\u001b[32m 807\u001b[39m \u001b[33m\"\u001b[39m\u001b[33mn_splits=\u001b[39m\u001b[38;5;132;01m%d\u001b[39;00m\u001b[33m cannot be greater than the\u001b[39m\u001b[33m\"\u001b[39m\n\u001b[32m 808\u001b[39m \u001b[33m\"\u001b[39m\u001b[33m number of members in each class.\u001b[39m\u001b[33m\"\u001b[39m % (\u001b[38;5;28mself\u001b[39m.n_splits)\n\u001b[32m 809\u001b[39m )\n\u001b[32m 810\u001b[39m \u001b[38;5;28;01mif\u001b[39;00m \u001b[38;5;28mself\u001b[39m.n_splits > min_groups:\n\u001b[32m 811\u001b[39m warnings.warn(\n\u001b[32m 812\u001b[39m \u001b[33m\"\u001b[39m\u001b[33mThe least populated class in y has only \u001b[39m\u001b[38;5;132;01m%d\u001b[39;00m\u001b[33m\"\u001b[39m\n\u001b[32m 813\u001b[39m \u001b[33m\"\u001b[39m\u001b[33m members, which is less than n_splits=\u001b[39m\u001b[38;5;132;01m%d\u001b[39;00m\u001b[33m.\u001b[39m\u001b[33m\"\u001b[39m\n\u001b[32m 814\u001b[39m % (min_groups, \u001b[38;5;28mself\u001b[39m.n_splits),\n\u001b[32m 815\u001b[39m \u001b[38;5;167;01mUserWarning\u001b[39;00m,\n\u001b[32m 816\u001b[39m )\n", - "\u001b[31mValueError\u001b[39m: n_splits=5 cannot be greater than the number of members in each class." + "name": "stdout", + "output_type": "stream", + "text": [ + " epoch train_loss dur\n", + "------- ------------ ------\n", + " 1 \u001b[36m0.8461\u001b[0m 0.1419\n", + " 2 \u001b[36m0.6572\u001b[0m 0.0161\n", + " 3 0.7241 0.0000\n", + " 4 0.6856 0.0183\n", + " 5 \u001b[36m0.5405\u001b[0m 0.0114\n", + " 6 0.9785 0.0000\n", + " 7 0.8498 0.0159\n", + " 8 0.8247 0.0000\n", + " 9 0.7223 0.0157\n", + " 10 0.6711 0.0000\n", + " 11 0.6652 0.0158\n", + " 12 0.6684 0.0000\n", + " 13 0.7197 0.0158\n", + " 14 0.6808 0.0000\n", + " 15 0.5502 0.0158\n", + " 16 0.7807 0.0000\n", + " 17 0.6591 0.0159\n", + " 18 0.6840 0.0157\n", + " 19 0.6722 0.0000\n", + " 20 0.5827 0.0159\n", + " 21 0.8277 0.0090\n", + " 22 0.6763 0.0000\n", + " 23 0.7158 0.0162\n", + " 24 0.7339 0.0000\n", + " 25 0.7955 0.0152\n", + " 26 0.8719 0.0000\n", + " 27 0.6885 0.0157\n", + " 28 0.6226 0.0000\n", + " 29 0.6545 0.0150\n", + " 30 0.6366 0.0000\n", + " 31 0.6825 0.0158\n", + " 32 0.6082 0.0000\n", + " 33 0.7029 0.0165\n", + " 34 0.7299 0.0154\n", + " 35 0.9808 0.0000\n", + " 36 0.7594 0.0158\n", + " 37 0.8403 0.0039\n", + " 38 0.7218 0.0000\n", + " 39 0.7866 0.0161\n", + " 40 0.6794 0.0000\n", + " 41 0.7263 0.0160\n", + " 42 0.6516 0.0000\n", + " 43 0.6717 0.0158\n", + " 44 0.8348 0.0160\n", + " 45 0.7508 0.0000\n", + " 46 0.9021 0.0000\n", + " 47 0.7072 0.0150\n", + " 48 0.7792 0.0000\n", + " 49 0.7591 0.0159\n", + " 50 0.7266 0.0000\n", + " 51 0.6756 0.0157\n", + " 52 0.6163 0.0000\n", + " 53 0.6225 0.0160\n", + " 54 0.6639 0.0000\n", + " 55 0.7083 0.0159\n", + " 56 0.5963 0.0000\n", + " 57 0.7257 0.0157\n", + " 58 0.6405 0.0056\n", + " 59 0.7366 0.0102\n", + " 60 0.6195 0.0000\n", + " 61 0.7516 0.0158\n", + " 62 0.6718 0.0000\n", + " 63 0.5932 0.0159\n", + " 64 0.8882 0.0000\n", + " 65 0.7327 0.0160\n", + " 66 0.6991 0.0000\n", + " 67 0.6891 0.0157\n", + " 68 0.5933 0.0000\n", + " 69 0.8549 0.0111\n", + " 70 0.8108 0.0000\n", + " 71 \u001b[36m0.5103\u001b[0m 0.0153\n", + " 72 0.6099 0.0000\n", + " 73 0.7089 0.0157\n", + " 74 0.7832 0.0000\n", + " 75 0.8883 0.0000\n", + " 76 0.6810 0.0189\n", + " 77 0.8062 0.0000\n", + " 78 0.7043 0.0000\n", + " 79 0.7434 0.0159\n", + " 80 0.5981 0.0000\n", + " 81 0.8158 0.0176\n", + " 82 0.6205 0.0000\n", + " 83 0.6938 0.0000\n", + " 84 0.5907 0.0158\n", + " 85 0.7626 0.0000\n", + " 86 0.8219 0.0163\n", + " 87 0.8149 0.0000\n", + " 88 0.6653 0.0152\n", + " 89 0.9269 0.0000\n", + " 90 0.6597 0.0000\n", + " 91 0.6851 0.0160\n", + " 92 0.8428 0.0000\n", + " 93 0.8266 0.0160\n", + " 94 0.8843 0.0000\n", + " 95 0.7539 0.0000\n", + " 96 0.8180 0.0158\n", + " 97 0.8543 0.0000\n", + " 98 0.6094 0.0159\n", + " 99 0.7100 0.0000\n", + " 100 0.8850 0.0000\n", + " 101 0.7484 0.0158\n", + " 102 0.7033 0.0000\n", + " 103 0.6150 0.0101\n", + " 104 0.8367 0.0000\n", + " 105 0.5537 0.0000\n", + " 106 0.7578 0.0000\n", + " 107 0.7593 0.0000\n", + " 108 0.8357 0.0158\n", + " 109 0.8099 0.0088\n", + " 110 0.7393 0.0000\n", + " 111 0.6879 0.0000\n", + " 112 0.6998 0.0158\n", + " 113 0.6404 0.0000\n", + " 114 0.6996 0.0159\n", + " 115 0.8520 0.0000\n", + " 116 0.6182 0.0000\n", + " 117 0.6585 0.0179\n", + " 118 0.7316 0.0000\n", + " 119 1.1209 0.0139\n", + " 120 0.8521 0.0000\n", + " 121 0.7580 0.0000\n", + " 122 0.7664 0.0000\n", + " 123 0.6473 0.0000\n", + " 124 0.8394 0.0157\n", + " 125 0.6356 0.0070\n", + " 126 0.8493 0.0106\n", + " 127 0.8244 0.0120\n", + " 128 0.6774 0.0099\n", + " 129 0.6474 0.0085\n", + " 130 0.7050 0.0078\n", + " 131 0.7881 0.0136\n", + " 132 0.5723 0.0080\n", + " 133 0.7643 0.0076\n", + " 134 0.5388 0.0098\n", + " 135 0.7935 0.0080\n", + " 136 0.8746 0.0080\n", + " 137 0.7145 0.0071\n", + " 138 0.7351 0.0096\n", + " 139 0.6367 0.0103\n", + " 140 0.9759 0.0052\n", + " 141 0.5974 0.0126\n", + " 142 0.5716 0.0069\n", + " 143 0.7519 0.0074\n", + " 144 0.7116 0.0011\n", + " 145 0.6647 0.0123\n", + " 146 0.7062 0.0032\n", + " 147 0.7479 0.0000\n", + " 148 0.6261 0.0150\n", + " 149 0.6971 0.0000\n", + " 150 0.7539 0.0166\n", + " 151 0.8594 0.0000\n", + " 152 0.6066 0.0151\n", + " 153 0.8738 0.0016\n", + " 154 0.7141 0.0098\n", + " 155 0.7691 0.0052\n", + " 156 0.7982 0.0094\n", + " 157 0.6404 0.0071\n", + " 158 0.8334 0.0000\n", + " 159 0.7291 0.0151\n", + " 160 0.6554 0.0005\n", + " 161 0.6280 0.0097\n", + " 162 0.6236 0.0077\n", + " 163 0.5305 0.0000\n", + " 164 0.6411 0.0157\n", + " 165 0.6683 0.0000\n", + " 166 0.6695 0.0104\n", + " 167 0.7942 0.0087\n", + " 168 \u001b[36m0.4477\u001b[0m 0.0000\n", + " 169 0.7733 0.0184\n", + " 170 0.7497 0.0042\n", + " 171 0.6720 0.0098\n", + " 172 0.6226 0.0060\n", + " 173 0.5872 0.0061\n", + " 174 0.6602 0.0062\n", + " 175 0.7334 0.0060\n", + " 176 0.7552 0.0074\n", + " 177 0.6609 0.0000\n", + " 178 0.8628 0.0138\n", + " 179 0.6421 0.0000\n", + " 180 0.6228 0.0093\n", + " 181 0.6133 0.0069\n", + " 182 0.7955 0.0098\n", + " 183 0.6620 0.0083\n", + " 184 0.8551 0.0000\n", + " 185 0.6537 0.0054\n", + " 186 0.7264 0.0000\n", + " 187 0.7663 0.0098\n", + " 188 0.7279 0.0010\n", + " 189 0.7689 0.0104\n", + " 190 0.7475 0.0081\n", + " 191 0.7611 0.0000\n", + " 192 0.7346 0.0138\n", + " 193 0.8142 0.0006\n", + " 194 0.7191 0.0095\n", + " 195 0.8565 0.0096\n", + " 196 0.6862 0.0008\n", + " 197 0.6632 0.0129\n", + " 198 0.8455 0.0055\n", + " 199 0.7827 0.0000\n", + " 200 0.8276 0.0149\n" ] } ], @@ -218,10 +404,18 @@ }, { "cell_type": "code", - "execution_count": null, + "execution_count": 19, "id": "945dc876", "metadata": {}, - "outputs": [], + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "Training Accuracy: 0.6\n" + ] + } + ], "source": [ "# Optional: Evaluate training accuracy\n", "from sklearn.metrics import accuracy_score\n", From fa869d5d01b8908e7e4c7ff023d36a8598927cd4 Mon Sep 17 00:00:00 2001 From: satvshr Date: Sun, 3 Aug 2025 14:03:28 +0530 Subject: [PATCH 073/145] Added requested changes --- pyaptamer/aptanet/skorch.py | 70 ++++++++++++++++++------- pyaptamer/aptanet/tests/test_aptanet.py | 4 +- 2 files changed, 52 insertions(+), 22 deletions(-) diff --git a/pyaptamer/aptanet/skorch.py b/pyaptamer/aptanet/skorch.py index b992c579..a264a6e6 100644 --- a/pyaptamer/aptanet/skorch.py +++ b/pyaptamer/aptanet/skorch.py @@ -10,35 +10,65 @@ class SkorchAptaNet(NeuralNetBinaryClassifier): """ - A Skorch-based binary classifier using AptaNetMLP with a configurable threshold. + A Skorch-based binary classifier wrapping AptaNetMLP, with configurable + architecture and decision threshold for binary classification. - This class wraps a PyTorch-based multilayer perceptron (MLP) model `AptaNetMLP` - using the Skorch API. It is designed for binary classification tasks, using the - binary cross-entropy loss with logits (`BCEWithLogitsLoss`) and a configurable - threshold for converting predicted probabilities to class labels. + This model uses BCEWithLogitsLoss and allows users to customize the MLP + architecture using AptaNetMLP parameters, while maintaining compatibility + with scikit-learn utilities like GridSearchCV and Pipelines. Parameters ---------- - threshold : float, optional (default=0.5) - The decision threshold for converting probabilities into binary predictions. - Probabilities above this threshold are mapped to class 1, otherwise to class 0. + threshold : float, default=0.5 + Threshold for converting predicted probabilities into class labels. + + module__input_dim : int or None, optional + Input dimensionality. If None and `module__use_lazy=True`, lazy initialization + is used. + + module__hidden_dim : int, default=128 + Number of hidden units per hidden layer. + + module__n_hidden : int, default=7 + Number of hidden layers. + + module__dropout : float, default=0.3 + Dropout probability for AlphaDropout in each hidden layer. + + module__output_dim : int, default=1 + Output dimensionality (typically 1 for binary classification). + + module__use_lazy : bool, default=True + Whether to use `nn.LazyLinear` in the first layer. **kwargs : dict - Additional keyword arguments passed to `NeuralNetBinaryClassifier`. - To configure the underlying `AptaNetMLP` module, use the `module__` - syntax. For example, `module__hidden_size=128` will pass `hidden_size=128` - to `AptaNetMLP`. - - Methods - ------- - predict(X) - Predicts class labels for the input data `X` using the fitted model. - Returns binary predictions based on the specified threshold. + Additional parameters passed to `NeuralNetBinaryClassifier`, such as + training parameters (e.g. `max_epochs`, `lr`, `optimizer`) or callbacks. """ - def __init__(self, threshold=0.5, **kwargs): + def __init__( + self, + threshold=0.5, + module__input_dim=None, + module__hidden_dim=128, + module__n_hidden=7, + module__dropout=0.3, + module__output_dim=1, + module__use_lazy=True, + **kwargs, + ): self.threshold = threshold - super().__init__(module=AptaNetMLP, criterion=nn.BCEWithLogitsLoss, **kwargs) + super().__init__( + module=AptaNetMLP, + criterion=nn.BCEWithLogitsLoss, + module__input_dim=module__input_dim, + module__hidden_dim=module__hidden_dim, + module__n_hidden=module__n_hidden, + module__dropout=module__dropout, + module__output_dim=module__output_dim, + module__use_lazy=module__use_lazy, + **kwargs, + ) def predict(self, X): proba = self.predict_proba(X)[:, 1] diff --git a/pyaptamer/aptanet/tests/test_aptanet.py b/pyaptamer/aptanet/tests/test_aptanet.py index 1aa1ba20..bdb52dfa 100644 --- a/pyaptamer/aptanet/tests/test_aptanet.py +++ b/pyaptamer/aptanet/tests/test_aptanet.py @@ -1,6 +1,6 @@ import numpy as np import pytest -from sklearn.utils.estimator_checks import check_estimator +from sklearn.utils.estimator_checks import parametrize_with_checks from pyaptamer.aptanet import FeatureSelector from pyaptamer.aptanet.pipeline import pipe @@ -39,4 +39,4 @@ def test_sklearn_compatible_estimator(estimator): """ Test that FeatureSelector is compatible with scikit-learn estimator checks. """ - check_estimator(estimator) + parametrize_with_checks(estimator) From e0d0af3a5770db6521fc25e90df24657ee5251a9 Mon Sep 17 00:00:00 2001 From: =?UTF-8?q?Franz=20Kir=C3=A1ly?= Date: Sun, 3 Aug 2025 19:18:05 +0200 Subject: [PATCH 074/145] Update pyproject.toml --- pyproject.toml | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/pyproject.toml b/pyproject.toml index 8fd6d55e..ed3b6f5b 100644 --- a/pyproject.toml +++ b/pyproject.toml @@ -13,7 +13,7 @@ authors = [ ] dependencies = [ - "biopython>=1.83" + "biopython>=1.83", "openmm>=8.3.0,<8.4.0", "pandas>=2.0.0", "scikit-learn>=1.3.0", From 5a10d65d1fe3067e0f1b00383342438ffffcab66 Mon Sep 17 00:00:00 2001 From: =?UTF-8?q?Franz=20Kir=C3=A1ly?= Date: Sun, 3 Aug 2025 19:18:53 +0200 Subject: [PATCH 075/145] Update pyproject.toml --- pyproject.toml | 3 +-- 1 file changed, 1 insertion(+), 2 deletions(-) diff --git a/pyproject.toml b/pyproject.toml index ed3b6f5b..38eb9a48 100644 --- a/pyproject.toml +++ b/pyproject.toml @@ -25,8 +25,7 @@ dev = [ "ruff>=0.12.0", "pytest>=8.0.0", "pre-commit", - "python>=12.0.0,<13.0.0" - "pre-commit", + "python>=12.0.0,<13.0.0", ] [tool.ruff] From 64fd01b513490e9d8e63772c22dc87bc241cc47f Mon Sep 17 00:00:00 2001 From: satvshr Date: Mon, 4 Aug 2025 00:11:53 +0530 Subject: [PATCH 076/145] Changed workflow file to stop testing for python 3.13 --- .github/workflows/test.yml | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/.github/workflows/test.yml b/.github/workflows/test.yml index 890cd486..3ae9457e 100644 --- a/.github/workflows/test.yml +++ b/.github/workflows/test.yml @@ -67,7 +67,7 @@ jobs: strategy: fail-fast: false matrix: - python-version: ["3.10", "3.11", "3.12", "3.13"] + python-version: ["3.10", "3.11", "3.12"] os: [ubuntu-latest, windows-latest, macOS-latest] runs-on: ${{ matrix.os }} steps: From eeef5d6a4dce75b071c58e85d5f88fba6f748c60 Mon Sep 17 00:00:00 2001 From: satvshr Date: Mon, 4 Aug 2025 00:14:45 +0530 Subject: [PATCH 077/145] Added skorch as a dependency --- pyproject.toml | 1 + 1 file changed, 1 insertion(+) diff --git a/pyproject.toml b/pyproject.toml index c65de0f8..636f518a 100644 --- a/pyproject.toml +++ b/pyproject.toml @@ -20,6 +20,7 @@ dependencies = [ "scikit-base", "torch>=2.5.1", "scikit-learn>=1.3.0", + "skorch" ] [project.optional-dependencies] From 144b4058ba55c4a5eec9d8ee0252f08946b582e4 Mon Sep 17 00:00:00 2001 From: satvshr Date: Mon, 4 Aug 2025 00:25:30 +0530 Subject: [PATCH 078/145] bug fix --- pyaptamer/aptanet/tests/test_aptanet.py | 9 +++------ 1 file changed, 3 insertions(+), 6 deletions(-) diff --git a/pyaptamer/aptanet/tests/test_aptanet.py b/pyaptamer/aptanet/tests/test_aptanet.py index bdb52dfa..079af70d 100644 --- a/pyaptamer/aptanet/tests/test_aptanet.py +++ b/pyaptamer/aptanet/tests/test_aptanet.py @@ -34,9 +34,6 @@ def test_pipeline_fit_and_predict(aptamer_seq, protein_seq): assert set(preds).issubset({0, 1}) -@pytest.mark.parametrize("estimator", [FeatureSelector()]) -def test_sklearn_compatible_estimator(estimator): - """ - Test that FeatureSelector is compatible with scikit-learn estimator checks. - """ - parametrize_with_checks(estimator) +@parametrize_with_checks([FeatureSelector()]) +def test_sklearn_compatible_estimator(estimator, check): + check(estimator) From ae9a81409c6ecdfa4ad63a7a856e10e2ccbc57ee Mon Sep 17 00:00:00 2001 From: satvshr Date: Mon, 4 Aug 2025 00:50:14 +0530 Subject: [PATCH 079/145] Removed 3.13 as a non dependency --- pyproject.toml | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/pyproject.toml b/pyproject.toml index 636f518a..f9d97467 100644 --- a/pyproject.toml +++ b/pyproject.toml @@ -7,7 +7,7 @@ name = "pyaptamer" version = "0.0.1.dev0" description = "Python library for aptamer simulation" readme = "README.md" -requires-python = ">=3.10,<3.13" +requires-python = ">=3.10" authors = [ {name="German Center for Open Source AI", email="info@gcos.ai"} ] From e9846bc9fe43b07c4cc29a716e516c4a7ebad336 Mon Sep 17 00:00:00 2001 From: satvshr Date: Mon, 4 Aug 2025 01:05:14 +0530 Subject: [PATCH 080/145] Added init file --- pyaptamer/utils/tests/__init__.py | 1 + 1 file changed, 1 insertion(+) create mode 100644 pyaptamer/utils/tests/__init__.py diff --git a/pyaptamer/utils/tests/__init__.py b/pyaptamer/utils/tests/__init__.py new file mode 100644 index 00000000..f31d22c5 --- /dev/null +++ b/pyaptamer/utils/tests/__init__.py @@ -0,0 +1 @@ +"""Tests for utilities in the pyaptamer package.""" From b80f145ed7b816f0f0a5eb4d789eac9ce11da803 Mon Sep 17 00:00:00 2001 From: satvshr Date: Mon, 4 Aug 2025 10:14:57 +0530 Subject: [PATCH 081/145] Added skip test --- .github/workflows/test.yml | 2 +- pyaptamer/aptanet/tests/test_aptanet.py | 5 +++++ 2 files changed, 6 insertions(+), 1 deletion(-) diff --git a/.github/workflows/test.yml b/.github/workflows/test.yml index 3ae9457e..890cd486 100644 --- a/.github/workflows/test.yml +++ b/.github/workflows/test.yml @@ -67,7 +67,7 @@ jobs: strategy: fail-fast: false matrix: - python-version: ["3.10", "3.11", "3.12"] + python-version: ["3.10", "3.11", "3.12", "3.13"] os: [ubuntu-latest, windows-latest, macOS-latest] runs-on: ${{ matrix.os }} steps: diff --git a/pyaptamer/aptanet/tests/test_aptanet.py b/pyaptamer/aptanet/tests/test_aptanet.py index 079af70d..c8ea3250 100644 --- a/pyaptamer/aptanet/tests/test_aptanet.py +++ b/pyaptamer/aptanet/tests/test_aptanet.py @@ -1,3 +1,5 @@ +import sys + import numpy as np import pytest from sklearn.utils.estimator_checks import parametrize_with_checks @@ -6,6 +8,9 @@ from pyaptamer.aptanet.pipeline import pipe +@pytest.mark.skipif( + sys.version_info >= (3, 13), reason="skorch does not support Python 3.13" +) @pytest.mark.parametrize( "aptamer_seq, protein_seq", [ From eef91ffb069ea7516dfe297f91fd052cda0fc854 Mon Sep 17 00:00:00 2001 From: satvshr Date: Mon, 4 Aug 2025 10:33:02 +0530 Subject: [PATCH 082/145] Added test --- pyaptamer/aptanet/tests/test_aptanet.py | 3 ++- 1 file changed, 2 insertions(+), 1 deletion(-) diff --git a/pyaptamer/aptanet/tests/test_aptanet.py b/pyaptamer/aptanet/tests/test_aptanet.py index c8ea3250..319ebfdc 100644 --- a/pyaptamer/aptanet/tests/test_aptanet.py +++ b/pyaptamer/aptanet/tests/test_aptanet.py @@ -5,7 +5,6 @@ from sklearn.utils.estimator_checks import parametrize_with_checks from pyaptamer.aptanet import FeatureSelector -from pyaptamer.aptanet.pipeline import pipe @pytest.mark.skipif( @@ -28,6 +27,8 @@ def test_pipeline_fit_and_predict(aptamer_seq, protein_seq): ------- Pipeline predictions are valid class labels and shape matches input. """ + from pyaptamer.aptanet.pipeline import pipe + X_raw = [(aptamer_seq, protein_seq) for _ in range(40)] y = np.array([0] * 20 + [1] * 20, dtype=np.float32) From 6f04f11e6a0a6f3e41c15cfed38811c2a18f139a Mon Sep 17 00:00:00 2001 From: satvshr Date: Mon, 4 Aug 2025 12:06:43 +0530 Subject: [PATCH 083/145] Added init file --- pyaptamer/utils/tests/__init__.py | 1 + 1 file changed, 1 insertion(+) create mode 100644 pyaptamer/utils/tests/__init__.py diff --git a/pyaptamer/utils/tests/__init__.py b/pyaptamer/utils/tests/__init__.py new file mode 100644 index 00000000..5f29e665 --- /dev/null +++ b/pyaptamer/utils/tests/__init__.py @@ -0,0 +1 @@ +"""Added tests for utils module.""" From 63226a5b99f7e8b75248a12a7bed9440884b09f6 Mon Sep 17 00:00:00 2001 From: satvshr Date: Mon, 4 Aug 2025 12:09:45 +0530 Subject: [PATCH 084/145] Removed loader folder --- pyaptamer/datasets/loader/__init__.py | 6 ------ pyaptamer/datasets/loader/one_gnh.py | 25 ------------------------ pyaptamer/datasets/loader/pfoa_loader.py | 25 ------------------------ 3 files changed, 56 deletions(-) delete mode 100644 pyaptamer/datasets/loader/__init__.py delete mode 100644 pyaptamer/datasets/loader/one_gnh.py delete mode 100644 pyaptamer/datasets/loader/pfoa_loader.py diff --git a/pyaptamer/datasets/loader/__init__.py b/pyaptamer/datasets/loader/__init__.py deleted file mode 100644 index c9c91fab..00000000 --- a/pyaptamer/datasets/loader/__init__.py +++ /dev/null @@ -1,6 +0,0 @@ -"""Loaders for different data structures.""" - -from pyaptamer.datasets.loader.one_gnh import load_1gnh_structure -from pyaptamer.datasets.loader.pfoa_loader import load_pfoa_structure - -__all__ = ["load_pfoa_structure", "load_1gnh_structure"] diff --git a/pyaptamer/datasets/loader/one_gnh.py b/pyaptamer/datasets/loader/one_gnh.py deleted file mode 100644 index bdddb796..00000000 --- a/pyaptamer/datasets/loader/one_gnh.py +++ /dev/null @@ -1,25 +0,0 @@ -import os - -from Bio.PDB import PDBParser - - -def load_1gnh_structure(pdb_path=None): - """ - Load the 1gnh molecule from a PDB file using Biopython. - - Parameters - ---------- - pdb_path : str, optional - Path to the PDB file. If not provided, the function uses the default path - located in the '../data/1gnh.pdb' relative to the current file. - - Returns - ------- - structure : Bio.PDB.Structure.Structure - A Biopython Structure object representing the PFOA molecule. - """ - pdb_path = os.path.join(os.path.dirname(__file__), "..", "data", "1gnh.pdb") - - parser = PDBParser(QUIET=True) - structure = parser.get_structure("1gnh", pdb_path) - return structure diff --git a/pyaptamer/datasets/loader/pfoa_loader.py b/pyaptamer/datasets/loader/pfoa_loader.py deleted file mode 100644 index bb56573b..00000000 --- a/pyaptamer/datasets/loader/pfoa_loader.py +++ /dev/null @@ -1,25 +0,0 @@ -import os - -from Bio.PDB import PDBParser - - -def load_pfoa_structure(pdb_path=None): - """ - Load the PFOA molecule from a PDB file using Biopython. - - Parameters - ---------- - pdb_path : str, optional - Path to the PDB file. If not provided, the function uses the default path - located in the '../data/pfoa.pdb' relative to the current file. - - Returns - ------- - structure : Bio.PDB.Structure.Structure - A Biopython Structure object representing the PFOA molecule. - """ - pdb_path = os.path.join(os.path.dirname(__file__), "..", "data", "pfoa.pdb") - - parser = PDBParser(QUIET=True) - structure = parser.get_structure("PFOA", pdb_path) - return structure From 9a74b71912c396d7e5d4b3f8298afee74306a3b1 Mon Sep 17 00:00:00 2001 From: satvshr Date: Mon, 4 Aug 2025 12:13:28 +0530 Subject: [PATCH 085/145] fixed bug --- pyaptamer/utils/tests/test_struct_to_aaseq.py | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/pyaptamer/utils/tests/test_struct_to_aaseq.py b/pyaptamer/utils/tests/test_struct_to_aaseq.py index 16a1e021..e622daa3 100644 --- a/pyaptamer/utils/tests/test_struct_to_aaseq.py +++ b/pyaptamer/utils/tests/test_struct_to_aaseq.py @@ -1,4 +1,4 @@ -from pyaptamer.datasets.loader import load_1gnh_structure +from pyaptamer.datasets import load_1gnh_structure from pyaptamer.utils.struct_to_aaseq import struct_to_aaseq From ac6851c79004525f03bd9379b65f2388d3e2877b Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Mon, 4 Aug 2025 19:08:08 +0530 Subject: [PATCH 086/145] Removed unecessary classes --- pyaptamer/aptanet/feature_selector.py | 63 --------------------- pyaptamer/aptanet/pipeline.py | 44 ++++++++++----- pyaptamer/aptanet/skorch.py | 75 ------------------------- pyaptamer/aptanet/tests/test_aptanet.py | 8 --- 4 files changed, 30 insertions(+), 160 deletions(-) delete mode 100644 pyaptamer/aptanet/feature_selector.py delete mode 100644 pyaptamer/aptanet/skorch.py diff --git a/pyaptamer/aptanet/feature_selector.py b/pyaptamer/aptanet/feature_selector.py deleted file mode 100644 index 44af4b26..00000000 --- a/pyaptamer/aptanet/feature_selector.py +++ /dev/null @@ -1,63 +0,0 @@ -__author__ = "satvshr" -__all__ = ["FeatureSelector"] - -from sklearn.base import BaseEstimator, TransformerMixin -from sklearn.ensemble import RandomForestClassifier -from sklearn.feature_selection import SelectFromModel -from sklearn.utils.validation import check_is_fitted, validate_data - - -class FeatureSelector(TransformerMixin, BaseEstimator): - """ - Feature selector using a Random Forest classifier to identify and retain - important features based on feature importances. - - This transformer can be used in scikit-learn pipelines to perform automatic - feature selection as a preprocessing step before model training. - - Parameters - ---------- - n_estimators : int, optional - Number of trees in the random forest. Default is 300. - - max_depth : int, optional - Maximum depth of the trees. Default is 9. - - random_state : int, optional - Seed used by the random number generator. Default is 0. - - Attributes - ---------- - clf_ : RandomForestClassifier - Fitted random forest classifier used to compute feature importances. - - clf_model_ : SelectFromModel - Model used to select features based on importances from the fitted classifier. - """ - - def __init__(self, n_estimators=300, max_depth=9, random_state=0): - self.n_estimators = n_estimators - self.max_depth = max_depth - self.random_state = random_state - - def fit(self, X, y): - X, y = validate_data(self, X, y) - - self.clf_ = RandomForestClassifier( - n_estimators=self.n_estimators, - max_depth=self.max_depth, - random_state=self.random_state, - ) - self.clf_.fit(X, y) - self.clf_model_ = SelectFromModel(self.clf_, prefit=True) - return self - - def transform(self, X): - check_is_fitted(self) - - X = validate_data(self, X, reset=False) - - if not hasattr(self, "clf_model_"): - raise ValueError("Feature selector has not been fitted yet.") - - return self.clf_model_.transform(X) diff --git a/pyaptamer/aptanet/pipeline.py b/pyaptamer/aptanet/pipeline.py index c63693ec..9fd7e612 100644 --- a/pyaptamer/aptanet/pipeline.py +++ b/pyaptamer/aptanet/pipeline.py @@ -1,22 +1,28 @@ -import torch -import torch.optim as optim +__author__ = "satvshr" +__all__ = ["pipe"] +__required__ = ["python>=3.9,<3.12"] + +import torch.nn as nn +from sklearn.ensemble import RandomForestClassifier +from sklearn.feature_selection import SelectFromModel from sklearn.pipeline import Pipeline from sklearn.preprocessing import FunctionTransformer +from skorch import NeuralNetBinaryClassifier -from pyaptamer.aptanet import FeatureSelector, SkorchAptaNet +from pyaptamer.aptanet.aptanet_nn import AptaNetMLP from pyaptamer.utils._aptanet_utils import pairs_to_features -net = SkorchAptaNet( - module__hidden_dim=128, - module__n_hidden=7, +net = NeuralNetBinaryClassifier( + module=AptaNetMLP, + module__input_dim=128, + module__hidden_dim=64, + module__n_hidden=5, module__dropout=0.3, - max_epochs=200, - lr=1.4e-4, - batch_size=310, - optimizer=optim.RMSprop, - device="cuda" if torch.cuda.is_available() else "cpu", - threshold=0.5, - verbose=1, + module__output_dim=1, + module__use_lazy=False, + criterion=nn.BCEWithLogitsLoss, + max_epochs=20, + lr=0.01, ) feature_transformer = FunctionTransformer( @@ -27,6 +33,16 @@ kw_args={}, ) +# Direct feature selection using tree-based model +feature_selector = SelectFromModel( + estimator=RandomForestClassifier(n_estimators=300, max_depth=9, random_state=0), + threshold="mean", +) + pipe = Pipeline( - [("features", feature_transformer), ("select", FeatureSelector()), ("clf", net)] + [ + ("features", feature_transformer), + ("select", feature_selector), + ("clf", net), + ] ) diff --git a/pyaptamer/aptanet/skorch.py b/pyaptamer/aptanet/skorch.py deleted file mode 100644 index a264a6e6..00000000 --- a/pyaptamer/aptanet/skorch.py +++ /dev/null @@ -1,75 +0,0 @@ -__author__ = "satvshr" -__all__ = ["SkorchAptaNet"] -__required__ = ["python>=3.9,<3.12"] - -import torch.nn as nn -from skorch import NeuralNetBinaryClassifier - -from pyaptamer.aptanet.aptanet_nn import AptaNetMLP - - -class SkorchAptaNet(NeuralNetBinaryClassifier): - """ - A Skorch-based binary classifier wrapping AptaNetMLP, with configurable - architecture and decision threshold for binary classification. - - This model uses BCEWithLogitsLoss and allows users to customize the MLP - architecture using AptaNetMLP parameters, while maintaining compatibility - with scikit-learn utilities like GridSearchCV and Pipelines. - - Parameters - ---------- - threshold : float, default=0.5 - Threshold for converting predicted probabilities into class labels. - - module__input_dim : int or None, optional - Input dimensionality. If None and `module__use_lazy=True`, lazy initialization - is used. - - module__hidden_dim : int, default=128 - Number of hidden units per hidden layer. - - module__n_hidden : int, default=7 - Number of hidden layers. - - module__dropout : float, default=0.3 - Dropout probability for AlphaDropout in each hidden layer. - - module__output_dim : int, default=1 - Output dimensionality (typically 1 for binary classification). - - module__use_lazy : bool, default=True - Whether to use `nn.LazyLinear` in the first layer. - - **kwargs : dict - Additional parameters passed to `NeuralNetBinaryClassifier`, such as - training parameters (e.g. `max_epochs`, `lr`, `optimizer`) or callbacks. - """ - - def __init__( - self, - threshold=0.5, - module__input_dim=None, - module__hidden_dim=128, - module__n_hidden=7, - module__dropout=0.3, - module__output_dim=1, - module__use_lazy=True, - **kwargs, - ): - self.threshold = threshold - super().__init__( - module=AptaNetMLP, - criterion=nn.BCEWithLogitsLoss, - module__input_dim=module__input_dim, - module__hidden_dim=module__hidden_dim, - module__n_hidden=module__n_hidden, - module__dropout=module__dropout, - module__output_dim=module__output_dim, - module__use_lazy=module__use_lazy, - **kwargs, - ) - - def predict(self, X): - proba = self.predict_proba(X)[:, 1] - return (proba > self.threshold).astype(int) diff --git a/pyaptamer/aptanet/tests/test_aptanet.py b/pyaptamer/aptanet/tests/test_aptanet.py index 319ebfdc..fce73b78 100644 --- a/pyaptamer/aptanet/tests/test_aptanet.py +++ b/pyaptamer/aptanet/tests/test_aptanet.py @@ -2,9 +2,6 @@ import numpy as np import pytest -from sklearn.utils.estimator_checks import parametrize_with_checks - -from pyaptamer.aptanet import FeatureSelector @pytest.mark.skipif( @@ -38,8 +35,3 @@ def test_pipeline_fit_and_predict(aptamer_seq, protein_seq): assert preds.shape == (40,) assert set(preds).issubset({0, 1}) - - -@parametrize_with_checks([FeatureSelector()]) -def test_sklearn_compatible_estimator(estimator, check): - check(estimator) From 3adb75ac49adf619de528b9f055bcc531ccfa537 Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Mon, 4 Aug 2025 19:10:41 +0530 Subject: [PATCH 087/145] Fixed some bugs and renames --- pyaptamer/aptanet/__init__.py | 5 ++--- pyaptamer/aptanet/pipeline.py | 12 ++++++------ pyaptamer/aptanet/tests/test_aptanet.py | 2 +- 3 files changed, 9 insertions(+), 10 deletions(-) diff --git a/pyaptamer/aptanet/__init__.py b/pyaptamer/aptanet/__init__.py index da411b74..c10c0fbf 100644 --- a/pyaptamer/aptanet/__init__.py +++ b/pyaptamer/aptanet/__init__.py @@ -1,6 +1,5 @@ """The AptaNet algorithm""" -from pyaptamer.aptanet.feature_selector import FeatureSelector -from pyaptamer.aptanet.skorch import SkorchAptaNet +from pyaptamer.aptanet.pipeline import pipe -__all__ = ["FeatureSelector", "SkorchAptaNet"] +__all__ = ["pipe"] diff --git a/pyaptamer/aptanet/pipeline.py b/pyaptamer/aptanet/pipeline.py index 9fd7e612..b3497276 100644 --- a/pyaptamer/aptanet/pipeline.py +++ b/pyaptamer/aptanet/pipeline.py @@ -12,7 +12,7 @@ from pyaptamer.aptanet.aptanet_nn import AptaNetMLP from pyaptamer.utils._aptanet_utils import pairs_to_features -net = NeuralNetBinaryClassifier( +_net = NeuralNetBinaryClassifier( module=AptaNetMLP, module__input_dim=128, module__hidden_dim=64, @@ -25,7 +25,7 @@ lr=0.01, ) -feature_transformer = FunctionTransformer( +_feature_transformer = FunctionTransformer( func=pairs_to_features, validate=False, # Optional arguments for pairs_to_features @@ -34,15 +34,15 @@ ) # Direct feature selection using tree-based model -feature_selector = SelectFromModel( +_feature_selector = SelectFromModel( estimator=RandomForestClassifier(n_estimators=300, max_depth=9, random_state=0), threshold="mean", ) pipe = Pipeline( [ - ("features", feature_transformer), - ("select", feature_selector), - ("clf", net), + ("features", _feature_transformer), + ("select", _feature_selector), + ("net", _net), ] ) diff --git a/pyaptamer/aptanet/tests/test_aptanet.py b/pyaptamer/aptanet/tests/test_aptanet.py index fce73b78..0b2f2013 100644 --- a/pyaptamer/aptanet/tests/test_aptanet.py +++ b/pyaptamer/aptanet/tests/test_aptanet.py @@ -24,7 +24,7 @@ def test_pipeline_fit_and_predict(aptamer_seq, protein_seq): ------- Pipeline predictions are valid class labels and shape matches input. """ - from pyaptamer.aptanet.pipeline import pipe + from pyaptamer.aptanet import pipe X_raw = [(aptamer_seq, protein_seq) for _ in range(40)] y = np.array([0] * 20 + [1] * 20, dtype=np.float32) From 2aeea116ff633c55d80cb913c03092b2235dd15b Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Tue, 5 Aug 2025 19:29:42 +0530 Subject: [PATCH 088/145] Changed pipeline to a class. --- pyaptamer/aptanet/pipeline.py | 148 +++++++++++++++++++++++++--------- 1 file changed, 112 insertions(+), 36 deletions(-) diff --git a/pyaptamer/aptanet/pipeline.py b/pyaptamer/aptanet/pipeline.py index b3497276..5248f455 100644 --- a/pyaptamer/aptanet/pipeline.py +++ b/pyaptamer/aptanet/pipeline.py @@ -1,5 +1,5 @@ __author__ = "satvshr" -__all__ = ["pipe"] +__all__ = ["AptaPipeline"] __required__ = ["python>=3.9,<3.12"] import torch.nn as nn @@ -7,42 +7,118 @@ from sklearn.feature_selection import SelectFromModel from sklearn.pipeline import Pipeline from sklearn.preprocessing import FunctionTransformer -from skorch import NeuralNetBinaryClassifier from pyaptamer.aptanet.aptanet_nn import AptaNetMLP from pyaptamer.utils._aptanet_utils import pairs_to_features -_net = NeuralNetBinaryClassifier( - module=AptaNetMLP, - module__input_dim=128, - module__hidden_dim=64, - module__n_hidden=5, - module__dropout=0.3, - module__output_dim=1, - module__use_lazy=False, - criterion=nn.BCEWithLogitsLoss, - max_epochs=20, - lr=0.01, -) - -_feature_transformer = FunctionTransformer( - func=pairs_to_features, - validate=False, - # Optional arguments for pairs_to_features - # example: kw_args={'k': 4, 'pseaac_kwargs': {'lambda_value': 30}} - kw_args={}, -) - -# Direct feature selection using tree-based model -_feature_selector = SelectFromModel( - estimator=RandomForestClassifier(n_estimators=300, max_depth=9, random_state=0), - threshold="mean", -) - -pipe = Pipeline( - [ - ("features", _feature_transformer), - ("select", _feature_selector), - ("net", _net), - ] -) + +class AptaPipeline(Pipeline): + """ + Pipeline for aptamer-pair classification combining feature extraction, + tree-based feature selection, and a skorch-wrapped neural network. + + Parameters + ---------- + input_dim : int, default=128 + Size of the input layer in the neural net. + hidden_dim : int, default=64 + Number of units in each hidden layer of the neural net. + n_hidden : int, default=5 + Number of hidden layers in the neural net. + dropout : float, default=0.3 + Dropout probability in the neural net. + max_epochs : int, default=20 + Maximum number of training epochs for the neural net. + lr : float, default=0.01 + Learning rate for the neural net optimizer. + n_estimators : int, default=300 + Number of trees in the RandomForest feature selector. + max_depth : int, default=9 + Maximum depth of each tree in the RandomForest. + random_state : int, default=0 + Random seed for reproducibility. + threshold : str or float, default="mean" + Threshold for SelectFromModel (e.g. "mean" or a float). + pairs_to_features_kwargs : dict, default=None + Extra keyword arguments passed to `pairs_to_features`. For example: + pairs_to_features_kwargs = { + 'k': 4, + 'pseaac_kwargs': { + 'lambda_value': 30 + } + } + + Attributes + ---------- + steps : list of (str, estimator) tuples + Pipeline steps: "features" → FunctionTransformer, + "select" → SelectFromModel, "net" → NeuralNetBinaryClassifier. + + Examples + -------- + >>> pipe = AptaPipeline(max_epochs=50, lr=0.005) + >>> pipe.fit(X_train, y_train) + >>> preds = pipe.predict(X_test) + """ + + def __init__( + self, + input_dim=None, + hidden_dim=128, + n_hidden=7, + dropout=0.3, + max_epochs=20, + lr=0.00014, + n_estimators=300, + max_depth=9, + random_state=None, + threshold="mean", + pairs_to_features_kwargs=None, + ): + self.input_dim = input_dim + self.hidden_dim = hidden_dim + self.n_hidden = n_hidden + self.dropout = dropout + self.max_epochs = max_epochs + self.lr = lr + self.n_estimators = n_estimators + self.max_depth = max_depth + self.random_state = random_state + self.threshold = threshold + self.pairs_to_features_kwargs = pairs_to_features_kwargs or {} + + from skorch import NeuralNetBinaryClassifier + + _transformer = FunctionTransformer( + func=pairs_to_features, + validate=False, + kw_args=self.pairs_to_features_kwargs, + ) + _selector = SelectFromModel( + estimator=RandomForestClassifier( + n_estimators=self.n_estimators, + max_depth=self.max_depth, + random_state=self.random_state, + ), + threshold=self.threshold, + ) + _net = NeuralNetBinaryClassifier( + module=AptaNetMLP, + module__input_dim=self.input_dim, + module__hidden_dim=self.hidden_dim, + module__n_hidden=self.n_hidden, + module__dropout=self.dropout, + module__output_dim=1, + module__use_lazy=True, + criterion=nn.BCEWithLogitsLoss, + max_epochs=self.max_epochs, + lr=self.lr, + ) + + steps = [ + ("features", _transformer), + ("select", _selector), + ("net", _net), + ] + + super().__init__(steps) From 912ec72101ff580e3d9f1f2007b1fcd61e3e7efb Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Tue, 5 Aug 2025 19:40:42 +0530 Subject: [PATCH 089/145] Updated to add optimizer --- pyaptamer/aptanet/pipeline.py | 17 +++++++++++++++-- 1 file changed, 15 insertions(+), 2 deletions(-) diff --git a/pyaptamer/aptanet/pipeline.py b/pyaptamer/aptanet/pipeline.py index 5248f455..e8482b2e 100644 --- a/pyaptamer/aptanet/pipeline.py +++ b/pyaptamer/aptanet/pipeline.py @@ -7,6 +7,7 @@ from sklearn.feature_selection import SelectFromModel from sklearn.pipeline import Pipeline from sklearn.preprocessing import FunctionTransformer +from torch import optim from pyaptamer.aptanet.aptanet_nn import AptaNetMLP from pyaptamer.utils._aptanet_utils import pairs_to_features @@ -29,8 +30,13 @@ class AptaPipeline(Pipeline): Dropout probability in the neural net. max_epochs : int, default=20 Maximum number of training epochs for the neural net. - lr : float, default=0.01 - Learning rate for the neural net optimizer. + lr : float, default=0.00014 + Learning rate for the optimizer (RMSprop). + alpha : float, default=0.9 + Discounting factor (rho) for the squared‐gradient moving average in RMSprop. + eps : float or None, default=None + Epsilon value for numerical stability in RMSprop; if None, PyTorch’s default + (1e-08) is used. n_estimators : int, default=300 Number of trees in the RandomForest feature selector. max_depth : int, default=9 @@ -69,6 +75,8 @@ def __init__( dropout=0.3, max_epochs=20, lr=0.00014, + alpha=0.9, + eps=None, n_estimators=300, max_depth=9, random_state=None, @@ -81,6 +89,8 @@ def __init__( self.dropout = dropout self.max_epochs = max_epochs self.lr = lr + self.alpha = alpha + self.eps = eps self.n_estimators = n_estimators self.max_depth = max_depth self.random_state = random_state @@ -113,6 +123,9 @@ def __init__( criterion=nn.BCEWithLogitsLoss, max_epochs=self.max_epochs, lr=self.lr, + optimizer=optim.RMSprop, + optimizer__alpha=self.alpha, + optimizer__eps=self.eps, ) steps = [ From e29380a8fbbfdf50b682621bdf14d0e15a60f842 Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Wed, 6 Aug 2025 20:13:26 +0530 Subject: [PATCH 090/145] Fixed pipeline bug --- pyaptamer/aptanet/__init__.py | 4 ++-- pyaptamer/aptanet/pipeline.py | 2 +- pyaptamer/aptanet/tests/test_aptanet.py | 5 +++-- 3 files changed, 6 insertions(+), 5 deletions(-) diff --git a/pyaptamer/aptanet/__init__.py b/pyaptamer/aptanet/__init__.py index c10c0fbf..aede31f0 100644 --- a/pyaptamer/aptanet/__init__.py +++ b/pyaptamer/aptanet/__init__.py @@ -1,5 +1,5 @@ """The AptaNet algorithm""" -from pyaptamer.aptanet.pipeline import pipe +from pyaptamer.aptanet.pipeline import AptaPipeline -__all__ = ["pipe"] +__all__ = ["AptaPipeline"] diff --git a/pyaptamer/aptanet/pipeline.py b/pyaptamer/aptanet/pipeline.py index e8482b2e..9664f55c 100644 --- a/pyaptamer/aptanet/pipeline.py +++ b/pyaptamer/aptanet/pipeline.py @@ -76,7 +76,7 @@ def __init__( max_epochs=20, lr=0.00014, alpha=0.9, - eps=None, + eps=1e-08, n_estimators=300, max_depth=9, random_state=None, diff --git a/pyaptamer/aptanet/tests/test_aptanet.py b/pyaptamer/aptanet/tests/test_aptanet.py index 0b2f2013..988f60a1 100644 --- a/pyaptamer/aptanet/tests/test_aptanet.py +++ b/pyaptamer/aptanet/tests/test_aptanet.py @@ -24,13 +24,14 @@ def test_pipeline_fit_and_predict(aptamer_seq, protein_seq): ------- Pipeline predictions are valid class labels and shape matches input. """ - from pyaptamer.aptanet import pipe + from pyaptamer.aptanet import AptaPipeline + + pipe = AptaPipeline() X_raw = [(aptamer_seq, protein_seq) for _ in range(40)] y = np.array([0] * 20 + [1] * 20, dtype=np.float32) pipe.fit(X_raw, y) - preds = pipe.predict(X_raw) assert preds.shape == (40,) From 36f750da2f4fb85bc0858be95afce9eab39701d9 Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Sat, 9 Aug 2025 15:55:34 +0530 Subject: [PATCH 091/145] docstring save commit --- pyaptamer/aptanet/pipeline.py | 118 +++++++++++++++++++----- pyaptamer/aptanet/tests/test_aptanet.py | 22 +++-- pyaptamer/utils/_aptanet_utils.py | 3 + 3 files changed, 114 insertions(+), 29 deletions(-) diff --git a/pyaptamer/aptanet/pipeline.py b/pyaptamer/aptanet/pipeline.py index 9664f55c..47056908 100644 --- a/pyaptamer/aptanet/pipeline.py +++ b/pyaptamer/aptanet/pipeline.py @@ -2,22 +2,39 @@ __all__ = ["AptaPipeline"] __required__ = ["python>=3.9,<3.12"] +import numpy as np import torch.nn as nn +from sklearn.base import BaseEstimator, ClassifierMixin from sklearn.ensemble import RandomForestClassifier from sklearn.feature_selection import SelectFromModel from sklearn.pipeline import Pipeline from sklearn.preprocessing import FunctionTransformer +from sklearn.utils.multiclass import check_classification_targets +from sklearn.utils.validation import check_is_fitted, validate_data from torch import optim from pyaptamer.aptanet.aptanet_nn import AptaNetMLP from pyaptamer.utils._aptanet_utils import pairs_to_features -class AptaPipeline(Pipeline): +class AptaPipeline(ClassifierMixin, BaseEstimator): """ Pipeline for aptamer-pair classification combining feature extraction, tree-based feature selection, and a skorch-wrapped neural network. + This class wraps an internal sklearn Pipeline and delegates fit, predict, + and other methods to it, while allowing flexible configuration of each step. + + References + ---------- + + + - Emami, N., Ferdousi, R. AptaNet as a deep learning approach for aptamer–protein + interaction prediction. Sci Rep 11, 6074 (2021). https://doi.org/10.1038/s41598-021-85629-0 + - https://github.com/nedaemami/AptaNet + - https://www.nature.com/articles/s41598-021-85629-0.pdf + + Parameters ---------- input_dim : int, default=128 @@ -46,22 +63,26 @@ class AptaPipeline(Pipeline): threshold : str or float, default="mean" Threshold for SelectFromModel (e.g. "mean" or a float). pairs_to_features_kwargs : dict, default=None - Extra keyword arguments passed to `pairs_to_features`. For example: + Extra keyword arguments passed directly to `pairs_to_features`. Valid keys are: + + + - k : int, optional, default=4 + The k-mer size for generating aptamer k-mer vectors. + - pseaac_kwargs : dict, optional, default=None + + + Example: pairs_to_features_kwargs = { - 'k': 4, - 'pseaac_kwargs': { - 'lambda_value': 30 + "k": 4, + "pseaac_kwargs": { + "lambda_value": 30, + "w": 0.05 } } - Attributes - ---------- - steps : list of (str, estimator) tuples - Pipeline steps: "features" → FunctionTransformer, - "select" → SelectFromModel, "net" → NeuralNetBinaryClassifier. - Examples -------- + >>> from pyaptamer.aptanet.pipeline import AptaPipeline >>> pipe = AptaPipeline(max_epochs=50, lr=0.005) >>> pipe.fit(X_train, y_train) >>> preds = pipe.predict(X_test) @@ -96,15 +117,29 @@ def __init__( self.random_state = random_state self.threshold = threshold self.pairs_to_features_kwargs = pairs_to_features_kwargs or {} + self.pipeline_ = None + self.classes_ = None + + # ---------------------- internal helpers ---------------------- - from skorch import NeuralNetBinaryClassifier + def _build_pipeline(self): + """Build the inner sklearn Pipeline. Lazy-import skorch here.""" + try: + from skorch import NeuralNetBinaryClassifier # lazy import + except Exception as e: + raise ImportError( + "AptaPipeline requires 'skorch' at runtime. " + "Please install skorch (and a supported Python/PyTorch) to use the NN" + "step." + ) from e - _transformer = FunctionTransformer( + features = FunctionTransformer( func=pairs_to_features, - validate=False, + validate=False, # let raw strings pass through; conversion happens inside kw_args=self.pairs_to_features_kwargs, ) - _selector = SelectFromModel( + + selector = SelectFromModel( estimator=RandomForestClassifier( n_estimators=self.n_estimators, max_depth=self.max_depth, @@ -112,7 +147,8 @@ def __init__( ), threshold=self.threshold, ) - _net = NeuralNetBinaryClassifier( + + net = NeuralNetBinaryClassifier( module=AptaNetMLP, module__input_dim=self.input_dim, module__hidden_dim=self.hidden_dim, @@ -128,10 +164,48 @@ def __init__( optimizer__eps=self.eps, ) - steps = [ - ("features", _transformer), - ("select", _selector), - ("net", _net), - ] + return Pipeline([("features", features), ("select", selector), ("net", net)]) + + # ---------------------- sklearn API ---------------------- + + def fit(self, X, y): + # Disallow NaNs; allow non-numeric raw inputs to pass to transformer + X, y = validate_data( + self, + X=X, + y=y, + reset=True, + dtype=None, # keep strings; conversion is downstream + force_all_finite=True, # <- No NaNs allowed + ) + check_classification_targets(y) + # encode labels to ints; remember mapping + self.classes_, y_enc = np.unique(y, return_inverse=True) + + self.pipeline_ = self._build_pipeline() + self.pipeline_.fit(X, y_enc) + return self + + def predict(self, X): + check_is_fitted(self, "pipeline_") + X = validate_data( + self, + X=X, + y="no_validation", # do not require y at predict time + reset=False, + dtype=None, + force_all_finite=True, # <- No NaNs allowed + ) + y_enc = self.pipeline_.predict(X) + return self.classes_[y_enc] + + # ---------------------- sklearn test hints ---------------------- - super().__init__(steps) + def _more_tags(self): + # Relax checks that assume numeric X pre-transform; note non-determinism. + return { + "X_types": ["string", "categorical", "2darray"], + "non_deterministic": True, + "requires_y": True, + # intentionally not setting 'allow_nan' (NaNs are disallowed) + } diff --git a/pyaptamer/aptanet/tests/test_aptanet.py b/pyaptamer/aptanet/tests/test_aptanet.py index 988f60a1..11f2da91 100644 --- a/pyaptamer/aptanet/tests/test_aptanet.py +++ b/pyaptamer/aptanet/tests/test_aptanet.py @@ -2,6 +2,9 @@ import numpy as np import pytest +from sklearn.utils.estimator_checks import parametrize_with_checks + +from pyaptamer.aptanet import AptaPipeline @pytest.mark.skipif( @@ -18,14 +21,8 @@ ) def test_pipeline_fit_and_predict(aptamer_seq, protein_seq): """ - Test end‐to‐end Pipeline fitting and predicting on synthetic data. - - Asserts - ------- - Pipeline predictions are valid class labels and shape matches input. + Test if Pipeline predictions are valid class labels and shape matches input. """ - from pyaptamer.aptanet import AptaPipeline - pipe = AptaPipeline() X_raw = [(aptamer_seq, protein_seq) for _ in range(40)] @@ -36,3 +33,14 @@ def test_pipeline_fit_and_predict(aptamer_seq, protein_seq): assert preds.shape == (40,) assert set(preds).issubset({0, 1}) + + +@pytest.mark.skipif( + sys.version_info >= (3, 13), reason="skorch does not support Python 3.13" +) +@parametrize_with_checks([AptaPipeline()]) +def test_sklearn_compatible_estimator(estimator, check): + """ + Run scikit-learn's compatibility checks on the AptaPipeline. + """ + check(estimator) diff --git a/pyaptamer/utils/_aptanet_utils.py b/pyaptamer/utils/_aptanet_utils.py index 044dd56e..d0fb4d97 100644 --- a/pyaptamer/utils/_aptanet_utils.py +++ b/pyaptamer/utils/_aptanet_utils.py @@ -58,9 +58,12 @@ def pairs_to_features(X, k=4, pseaac_kwargs=None): Convert a list of (aptamer_sequence, protein_sequence) pairs into feature vectors. This function generates feature vectors for each (aptamer, protein) pair using: + + - k-mer representation of the aptamer sequence - Pseudo amino acid composition (PSeAAC) representation of the protein sequence + Parameters ---------- X : list of tuple of str From badfafe699960c830be8da5ebf77b92c19b328c0 Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Sun, 10 Aug 2025 00:16:35 +0530 Subject: [PATCH 092/145] Adding failures --- pyaptamer/aptanet/pipeline.py | 93 +++++++++-------------------------- 1 file changed, 22 insertions(+), 71 deletions(-) diff --git a/pyaptamer/aptanet/pipeline.py b/pyaptamer/aptanet/pipeline.py index 47056908..bf6c5ab4 100644 --- a/pyaptamer/aptanet/pipeline.py +++ b/pyaptamer/aptanet/pipeline.py @@ -9,7 +9,6 @@ from sklearn.feature_selection import SelectFromModel from sklearn.pipeline import Pipeline from sklearn.preprocessing import FunctionTransformer -from sklearn.utils.multiclass import check_classification_targets from sklearn.utils.validation import check_is_fitted, validate_data from torch import optim @@ -25,16 +24,6 @@ class AptaPipeline(ClassifierMixin, BaseEstimator): This class wraps an internal sklearn Pipeline and delegates fit, predict, and other methods to it, while allowing flexible configuration of each step. - References - ---------- - - - - Emami, N., Ferdousi, R. AptaNet as a deep learning approach for aptamer–protein - interaction prediction. Sci Rep 11, 6074 (2021). https://doi.org/10.1038/s41598-021-85629-0 - - https://github.com/nedaemami/AptaNet - - https://www.nature.com/articles/s41598-021-85629-0.pdf - - Parameters ---------- input_dim : int, default=128 @@ -116,30 +105,18 @@ def __init__( self.max_depth = max_depth self.random_state = random_state self.threshold = threshold - self.pairs_to_features_kwargs = pairs_to_features_kwargs or {} - self.pipeline_ = None - self.classes_ = None - - # ---------------------- internal helpers ---------------------- - - def _build_pipeline(self): - """Build the inner sklearn Pipeline. Lazy-import skorch here.""" - try: - from skorch import NeuralNetBinaryClassifier # lazy import - except Exception as e: - raise ImportError( - "AptaPipeline requires 'skorch' at runtime. " - "Please install skorch (and a supported Python/PyTorch) to use the NN" - "step." - ) from e - - features = FunctionTransformer( + self.pairs_to_features_kwargs = pairs_to_features_kwargs + + def fit(self, X, y): + from skorch import NeuralNetBinaryClassifier + + _transformer = FunctionTransformer( func=pairs_to_features, validate=False, # let raw strings pass through; conversion happens inside kw_args=self.pairs_to_features_kwargs, ) - selector = SelectFromModel( + _selector = SelectFromModel( estimator=RandomForestClassifier( n_estimators=self.n_estimators, max_depth=self.max_depth, @@ -148,7 +125,7 @@ def _build_pipeline(self): threshold=self.threshold, ) - net = NeuralNetBinaryClassifier( + _net = NeuralNetBinaryClassifier( module=AptaNetMLP, module__input_dim=self.input_dim, module__hidden_dim=self.hidden_dim, @@ -164,48 +141,22 @@ def _build_pipeline(self): optimizer__eps=self.eps, ) - return Pipeline([("features", features), ("select", selector), ("net", net)]) - - # ---------------------- sklearn API ---------------------- - - def fit(self, X, y): - # Disallow NaNs; allow non-numeric raw inputs to pass to transformer - X, y = validate_data( - self, - X=X, - y=y, - reset=True, - dtype=None, # keep strings; conversion is downstream - force_all_finite=True, # <- No NaNs allowed + self.pipeline_ = Pipeline( + [ + ("features", _transformer), + ("select", _selector), + ("net", _net), + ] ) - check_classification_targets(y) - # encode labels to ints; remember mapping - self.classes_, y_enc = np.unique(y, return_inverse=True) + X, y = validate_data(self, X, y) + self.classes_, y = np.unique(y, return_inverse=True) + self.pipeline_.fit(X, y) + self.is_fitted_ = True - self.pipeline_ = self._build_pipeline() - self.pipeline_.fit(X, y_enc) return self def predict(self, X): - check_is_fitted(self, "pipeline_") - X = validate_data( - self, - X=X, - y="no_validation", # do not require y at predict time - reset=False, - dtype=None, - force_all_finite=True, # <- No NaNs allowed - ) - y_enc = self.pipeline_.predict(X) - return self.classes_[y_enc] - - # ---------------------- sklearn test hints ---------------------- - - def _more_tags(self): - # Relax checks that assume numeric X pre-transform; note non-determinism. - return { - "X_types": ["string", "categorical", "2darray"], - "non_deterministic": True, - "requires_y": True, - # intentionally not setting 'allow_nan' (NaNs are disallowed) - } + check_is_fitted(self) + X = validate_data(self, X) + + return self.pipeline_.predict(X) From 66a162035a43a0fc09a583bd28e35e06909b05f9 Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Sun, 10 Aug 2025 01:57:53 +0530 Subject: [PATCH 093/145] Changed file names and added 2 classes --- pyaptamer/aptanet/__init__.py | 4 +- .../aptanet/{aptanet_nn.py => _aptanet_nn.py} | 0 pyaptamer/aptanet/_feature_classifier.py | 108 ++++++++++++ pyaptamer/aptanet/_pipeline.py | 41 +++++ pyaptamer/aptanet/pipeline.py | 162 ------------------ pyaptamer/aptanet/tests/test_aptanet.py | 7 +- 6 files changed, 155 insertions(+), 167 deletions(-) rename pyaptamer/aptanet/{aptanet_nn.py => _aptanet_nn.py} (100%) create mode 100644 pyaptamer/aptanet/_feature_classifier.py create mode 100644 pyaptamer/aptanet/_pipeline.py delete mode 100644 pyaptamer/aptanet/pipeline.py diff --git a/pyaptamer/aptanet/__init__.py b/pyaptamer/aptanet/__init__.py index aede31f0..fb10818c 100644 --- a/pyaptamer/aptanet/__init__.py +++ b/pyaptamer/aptanet/__init__.py @@ -1,5 +1,5 @@ """The AptaNet algorithm""" -from pyaptamer.aptanet.pipeline import AptaPipeline +from pyaptamer.aptanet._pipeline import AptaNetPipeline -__all__ = ["AptaPipeline"] +__all__ = ["AptaNetPipeline"] diff --git a/pyaptamer/aptanet/aptanet_nn.py b/pyaptamer/aptanet/_aptanet_nn.py similarity index 100% rename from pyaptamer/aptanet/aptanet_nn.py rename to pyaptamer/aptanet/_aptanet_nn.py diff --git a/pyaptamer/aptanet/_feature_classifier.py b/pyaptamer/aptanet/_feature_classifier.py new file mode 100644 index 00000000..db7238fa --- /dev/null +++ b/pyaptamer/aptanet/_feature_classifier.py @@ -0,0 +1,108 @@ +__author__ = "satvshr" +__all__ = ["AptaNetFeaturesClassifier"] +__required__ = ["python>=3.9,<3.12"] +import numpy as np +import torch +import torch.nn as nn +from sklearn.base import BaseEstimator, ClassifierMixin +from sklearn.ensemble import RandomForestClassifier +from sklearn.feature_selection import SelectFromModel +from sklearn.pipeline import Pipeline +from sklearn.utils.validation import check_is_fitted, validate_data +from torch import optim + +from pyaptamer.aptanet._aptanet_nn import AptaNetMLP + + +class AptaNetFeaturesClassifier(ClassifierMixin, BaseEstimator): + """ + Sklearn-compliant estimator that expects **numeric features** as X (2D array-like) + and performs: + (i) tree-based feature selection (RandomForest + SelectFromModel) + (ii) skorch-wrapped AptaNetMLP binary classifier. + + This class should be covered by sklearn's estimator checks. + """ + + def __init__( + self, + input_dim=None, + hidden_dim=128, + n_hidden=7, + dropout=0.3, + max_epochs=20, + lr=0.00014, + alpha=0.9, + eps=1e-08, + n_estimators=300, + max_depth=9, + random_state=None, + threshold="mean", + ): + self.input_dim = input_dim + self.hidden_dim = hidden_dim + self.n_hidden = n_hidden + self.dropout = dropout + self.max_epochs = max_epochs + self.lr = lr + self.alpha = alpha + self.eps = eps + self.n_estimators = n_estimators + self.max_depth = max_depth + self.random_state = random_state + self.threshold = threshold + + def _build_pipeline(self): + from skorch import NeuralNetBinaryClassifier + + selector = SelectFromModel( + estimator=RandomForestClassifier( + n_estimators=self.n_estimators, + max_depth=self.max_depth, + random_state=self.random_state, + ), + threshold=self.threshold, + ) + + net = NeuralNetBinaryClassifier( + module=AptaNetMLP, + module__input_dim=self.input_dim, + module__hidden_dim=self.hidden_dim, + module__n_hidden=self.n_hidden, + module__dropout=self.dropout, + module__output_dim=1, + module__use_lazy=True, + criterion=nn.BCEWithLogitsLoss, + max_epochs=self.max_epochs, + lr=self.lr, + optimizer=optim.RMSprop, + optimizer__alpha=self.alpha, + optimizer__eps=self.eps, + device="cuda" if torch.cuda.is_available() else "cpu", + ) + + return Pipeline([("select", selector), ("net", net)]) + + def fit(self, X, y): + X, y = validate_data(self, X, y) + # self.classes_, y = np.unique(y, return_inverse=True) + # if np.unique(y).size < 2: + # raise ValueError("AptaNetFeaturesClassifier requires at least two classes + # in y.") + # 2) encode labels to {0,1} BEFORE casting to float + # self.classes_, y = np.unique(y, return_inverse=True) + self.pipeline_ = self._build_pipeline() + X = X.astype(np.float32, copy=False) + y = y.astype(np.float32, copy=False) + self.pipeline_.fit(X, y) + # self.is_fitted_ = True + return self + + def predict(self, X): + check_is_fitted(self) + X = validate_data(self, X, reset=False) + X = X.astype(np.float32, copy=False) + + # y01 = self.pipeline_.predict(X).astype(int, copy=False) + # return self.classes_[y01] + return self.pipeline_.predict(X) diff --git a/pyaptamer/aptanet/_pipeline.py b/pyaptamer/aptanet/_pipeline.py new file mode 100644 index 00000000..75411036 --- /dev/null +++ b/pyaptamer/aptanet/_pipeline.py @@ -0,0 +1,41 @@ +__author__ = "satvshr" +__all__ = ["AptaNetPipeline"] +__required__ = ["python>=3.9,<3.12"] + +from sklearn.pipeline import Pipeline +from sklearn.preprocessing import FunctionTransformer + +from pyaptamer.aptanet._feature_classifier import AptaNetFeaturesClassifier +from pyaptamer.utils._aptanet_utils import pairs_to_features + + +class AptaNetPipeline: + """ + Convenience wrapper that accepts **string pairs** (raw aptamer pairs), + converts them to numeric features with `pairs_to_features`, and then + delegates to `AptaNetFeaturesClassifier`. + + This is *not* intended to be run through sklearn's estimator checks. + """ + + def __init__(self, pairs_to_features_kwargs=None, **features_classifier_kwargs): + self.pairs_to_features_kwargs = pairs_to_features_kwargs + self.features_classifier_kwargs = features_classifier_kwargs + + def _build_pipeline(self): + transformer = FunctionTransformer( + func=pairs_to_features, + kw_args=self.pairs_to_features_kwargs, + validate=False, # allow raw strings through + ) + clf = AptaNetFeaturesClassifier(**self.features_classifier_kwargs) + return Pipeline([("features", transformer), ("clf", clf)]) + + def fit(self, X, y): + self.pipeline_ = self._build_pipeline() + self.pipeline_.fit(X, y) + + def predict(self, X): + if not hasattr(self, "pipeline_"): + raise RuntimeError("Pipeline not fitted. Call fit() before predict().") + return self.pipeline_.predict(X) diff --git a/pyaptamer/aptanet/pipeline.py b/pyaptamer/aptanet/pipeline.py deleted file mode 100644 index bf6c5ab4..00000000 --- a/pyaptamer/aptanet/pipeline.py +++ /dev/null @@ -1,162 +0,0 @@ -__author__ = "satvshr" -__all__ = ["AptaPipeline"] -__required__ = ["python>=3.9,<3.12"] - -import numpy as np -import torch.nn as nn -from sklearn.base import BaseEstimator, ClassifierMixin -from sklearn.ensemble import RandomForestClassifier -from sklearn.feature_selection import SelectFromModel -from sklearn.pipeline import Pipeline -from sklearn.preprocessing import FunctionTransformer -from sklearn.utils.validation import check_is_fitted, validate_data -from torch import optim - -from pyaptamer.aptanet.aptanet_nn import AptaNetMLP -from pyaptamer.utils._aptanet_utils import pairs_to_features - - -class AptaPipeline(ClassifierMixin, BaseEstimator): - """ - Pipeline for aptamer-pair classification combining feature extraction, - tree-based feature selection, and a skorch-wrapped neural network. - - This class wraps an internal sklearn Pipeline and delegates fit, predict, - and other methods to it, while allowing flexible configuration of each step. - - Parameters - ---------- - input_dim : int, default=128 - Size of the input layer in the neural net. - hidden_dim : int, default=64 - Number of units in each hidden layer of the neural net. - n_hidden : int, default=5 - Number of hidden layers in the neural net. - dropout : float, default=0.3 - Dropout probability in the neural net. - max_epochs : int, default=20 - Maximum number of training epochs for the neural net. - lr : float, default=0.00014 - Learning rate for the optimizer (RMSprop). - alpha : float, default=0.9 - Discounting factor (rho) for the squared‐gradient moving average in RMSprop. - eps : float or None, default=None - Epsilon value for numerical stability in RMSprop; if None, PyTorch’s default - (1e-08) is used. - n_estimators : int, default=300 - Number of trees in the RandomForest feature selector. - max_depth : int, default=9 - Maximum depth of each tree in the RandomForest. - random_state : int, default=0 - Random seed for reproducibility. - threshold : str or float, default="mean" - Threshold for SelectFromModel (e.g. "mean" or a float). - pairs_to_features_kwargs : dict, default=None - Extra keyword arguments passed directly to `pairs_to_features`. Valid keys are: - - - - k : int, optional, default=4 - The k-mer size for generating aptamer k-mer vectors. - - pseaac_kwargs : dict, optional, default=None - - - Example: - pairs_to_features_kwargs = { - "k": 4, - "pseaac_kwargs": { - "lambda_value": 30, - "w": 0.05 - } - } - - Examples - -------- - >>> from pyaptamer.aptanet.pipeline import AptaPipeline - >>> pipe = AptaPipeline(max_epochs=50, lr=0.005) - >>> pipe.fit(X_train, y_train) - >>> preds = pipe.predict(X_test) - """ - - def __init__( - self, - input_dim=None, - hidden_dim=128, - n_hidden=7, - dropout=0.3, - max_epochs=20, - lr=0.00014, - alpha=0.9, - eps=1e-08, - n_estimators=300, - max_depth=9, - random_state=None, - threshold="mean", - pairs_to_features_kwargs=None, - ): - self.input_dim = input_dim - self.hidden_dim = hidden_dim - self.n_hidden = n_hidden - self.dropout = dropout - self.max_epochs = max_epochs - self.lr = lr - self.alpha = alpha - self.eps = eps - self.n_estimators = n_estimators - self.max_depth = max_depth - self.random_state = random_state - self.threshold = threshold - self.pairs_to_features_kwargs = pairs_to_features_kwargs - - def fit(self, X, y): - from skorch import NeuralNetBinaryClassifier - - _transformer = FunctionTransformer( - func=pairs_to_features, - validate=False, # let raw strings pass through; conversion happens inside - kw_args=self.pairs_to_features_kwargs, - ) - - _selector = SelectFromModel( - estimator=RandomForestClassifier( - n_estimators=self.n_estimators, - max_depth=self.max_depth, - random_state=self.random_state, - ), - threshold=self.threshold, - ) - - _net = NeuralNetBinaryClassifier( - module=AptaNetMLP, - module__input_dim=self.input_dim, - module__hidden_dim=self.hidden_dim, - module__n_hidden=self.n_hidden, - module__dropout=self.dropout, - module__output_dim=1, - module__use_lazy=True, - criterion=nn.BCEWithLogitsLoss, - max_epochs=self.max_epochs, - lr=self.lr, - optimizer=optim.RMSprop, - optimizer__alpha=self.alpha, - optimizer__eps=self.eps, - ) - - self.pipeline_ = Pipeline( - [ - ("features", _transformer), - ("select", _selector), - ("net", _net), - ] - ) - X, y = validate_data(self, X, y) - self.classes_, y = np.unique(y, return_inverse=True) - self.pipeline_.fit(X, y) - self.is_fitted_ = True - - return self - - def predict(self, X): - check_is_fitted(self) - X = validate_data(self, X) - - return self.pipeline_.predict(X) diff --git a/pyaptamer/aptanet/tests/test_aptanet.py b/pyaptamer/aptanet/tests/test_aptanet.py index 11f2da91..773b2c07 100644 --- a/pyaptamer/aptanet/tests/test_aptanet.py +++ b/pyaptamer/aptanet/tests/test_aptanet.py @@ -4,7 +4,8 @@ import pytest from sklearn.utils.estimator_checks import parametrize_with_checks -from pyaptamer.aptanet import AptaPipeline +from pyaptamer.aptanet import AptaNetPipeline +from pyaptamer.aptanet._pipeline import AptaNetFeaturesClassifier @pytest.mark.skipif( @@ -23,7 +24,7 @@ def test_pipeline_fit_and_predict(aptamer_seq, protein_seq): """ Test if Pipeline predictions are valid class labels and shape matches input. """ - pipe = AptaPipeline() + pipe = AptaNetPipeline() X_raw = [(aptamer_seq, protein_seq) for _ in range(40)] y = np.array([0] * 20 + [1] * 20, dtype=np.float32) @@ -38,7 +39,7 @@ def test_pipeline_fit_and_predict(aptamer_seq, protein_seq): @pytest.mark.skipif( sys.version_info >= (3, 13), reason="skorch does not support Python 3.13" ) -@parametrize_with_checks([AptaPipeline()]) +@parametrize_with_checks([AptaNetFeaturesClassifier()]) def test_sklearn_compatible_estimator(estimator, check): """ Run scikit-learn's compatibility checks on the AptaPipeline. From 98327d8954a477935a047ba3e83b1618d80c2ff9 Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Sun, 10 Aug 2025 02:12:41 +0530 Subject: [PATCH 094/145] Trying to make tests pass --- pyaptamer/aptanet/_feature_classifier.py | 6 +++--- 1 file changed, 3 insertions(+), 3 deletions(-) diff --git a/pyaptamer/aptanet/_feature_classifier.py b/pyaptamer/aptanet/_feature_classifier.py index db7238fa..55f930f4 100644 --- a/pyaptamer/aptanet/_feature_classifier.py +++ b/pyaptamer/aptanet/_feature_classifier.py @@ -90,7 +90,7 @@ def fit(self, X, y): # raise ValueError("AptaNetFeaturesClassifier requires at least two classes # in y.") # 2) encode labels to {0,1} BEFORE casting to float - # self.classes_, y = np.unique(y, return_inverse=True) + self.classes_, y = np.unique(y, return_inverse=True) self.pipeline_ = self._build_pipeline() X = X.astype(np.float32, copy=False) y = y.astype(np.float32, copy=False) @@ -103,6 +103,6 @@ def predict(self, X): X = validate_data(self, X, reset=False) X = X.astype(np.float32, copy=False) - # y01 = self.pipeline_.predict(X).astype(int, copy=False) - # return self.classes_[y01] + y01 = self.pipeline_.predict(X).astype(int, copy=False) + return self.classes_[y01] return self.pipeline_.predict(X) From f264228eab50e14941713f8b2ffa661293690749 Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Sun, 10 Aug 2025 02:14:19 +0530 Subject: [PATCH 095/145] Tests test --- pyaptamer/aptanet/_feature_classifier.py | 3 +++ 1 file changed, 3 insertions(+) diff --git a/pyaptamer/aptanet/_feature_classifier.py b/pyaptamer/aptanet/_feature_classifier.py index 55f930f4..2b977095 100644 --- a/pyaptamer/aptanet/_feature_classifier.py +++ b/pyaptamer/aptanet/_feature_classifier.py @@ -79,6 +79,9 @@ def _build_pipeline(self): optimizer__alpha=self.alpha, optimizer__eps=self.eps, device="cuda" if torch.cuda.is_available() else "cpu", + random_state=self.random_state, + train_split=None, + iterator_train__shuffle=False, ) return Pipeline([("select", selector), ("net", net)]) From 4a3a62282640311e41a13f74c78eaba64b4516fc Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Sun, 10 Aug 2025 02:26:07 +0530 Subject: [PATCH 096/145] Update _feature_classifier.py --- pyaptamer/aptanet/_feature_classifier.py | 36 +++++++++--------------- 1 file changed, 14 insertions(+), 22 deletions(-) diff --git a/pyaptamer/aptanet/_feature_classifier.py b/pyaptamer/aptanet/_feature_classifier.py index 2b977095..a2a88e91 100644 --- a/pyaptamer/aptanet/_feature_classifier.py +++ b/pyaptamer/aptanet/_feature_classifier.py @@ -1,6 +1,3 @@ -__author__ = "satvshr" -__all__ = ["AptaNetFeaturesClassifier"] -__required__ = ["python>=3.9,<3.12"] import numpy as np import torch import torch.nn as nn @@ -8,6 +5,7 @@ from sklearn.ensemble import RandomForestClassifier from sklearn.feature_selection import SelectFromModel from sklearn.pipeline import Pipeline +from sklearn.utils.multiclass import type_of_target from sklearn.utils.validation import check_is_fitted, validate_data from torch import optim @@ -15,15 +13,6 @@ class AptaNetFeaturesClassifier(ClassifierMixin, BaseEstimator): - """ - Sklearn-compliant estimator that expects **numeric features** as X (2D array-like) - and performs: - (i) tree-based feature selection (RandomForest + SelectFromModel) - (ii) skorch-wrapped AptaNetMLP binary classifier. - - This class should be covered by sklearn's estimator checks. - """ - def __init__( self, input_dim=None, @@ -59,7 +48,7 @@ def _build_pipeline(self): estimator=RandomForestClassifier( n_estimators=self.n_estimators, max_depth=self.max_depth, - random_state=self.random_state, + random_state=self.random_state, # RF can take it ), threshold=self.threshold, ) @@ -79,7 +68,6 @@ def _build_pipeline(self): optimizer__alpha=self.alpha, optimizer__eps=self.eps, device="cuda" if torch.cuda.is_available() else "cpu", - random_state=self.random_state, train_split=None, iterator_train__shuffle=False, ) @@ -88,24 +76,28 @@ def _build_pipeline(self): def fit(self, X, y): X, y = validate_data(self, X, y) - # self.classes_, y = np.unique(y, return_inverse=True) - # if np.unique(y).size < 2: - # raise ValueError("AptaNetFeaturesClassifier requires at least two classes - # in y.") - # 2) encode labels to {0,1} BEFORE casting to float + + # error on continuous targets (sklearn check expects this) + if "continuous" in type_of_target(y): + raise ValueError("continuous target is not supported for classification") + + # deterministic init if requested + if self.random_state is not None: + np.random.seed(self.random_state) + torch.manual_seed(self.random_state) + + # encode labels to {0,1} and expose classes_ self.classes_, y = np.unique(y, return_inverse=True) + self.pipeline_ = self._build_pipeline() X = X.astype(np.float32, copy=False) y = y.astype(np.float32, copy=False) self.pipeline_.fit(X, y) - # self.is_fitted_ = True return self def predict(self, X): check_is_fitted(self) X = validate_data(self, X, reset=False) X = X.astype(np.float32, copy=False) - y01 = self.pipeline_.predict(X).astype(int, copy=False) return self.classes_[y01] - return self.pipeline_.predict(X) From 11eef336d1975c33cb83a1143e590430f3f7ac3f Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Sun, 10 Aug 2025 17:13:18 +0530 Subject: [PATCH 097/145] Update _feature_classifier.py --- pyaptamer/aptanet/_feature_classifier.py | 11 ++++------- 1 file changed, 4 insertions(+), 7 deletions(-) diff --git a/pyaptamer/aptanet/_feature_classifier.py b/pyaptamer/aptanet/_feature_classifier.py index a2a88e91..8c5ec666 100644 --- a/pyaptamer/aptanet/_feature_classifier.py +++ b/pyaptamer/aptanet/_feature_classifier.py @@ -19,7 +19,7 @@ def __init__( hidden_dim=128, n_hidden=7, dropout=0.3, - max_epochs=20, + max_epochs=200, lr=0.00014, alpha=0.9, eps=1e-08, @@ -48,7 +48,7 @@ def _build_pipeline(self): estimator=RandomForestClassifier( n_estimators=self.n_estimators, max_depth=self.max_depth, - random_state=self.random_state, # RF can take it + random_state=self.random_state, ), threshold=self.threshold, ) @@ -77,16 +77,13 @@ def _build_pipeline(self): def fit(self, X, y): X, y = validate_data(self, X, y) - # error on continuous targets (sklearn check expects this) if "continuous" in type_of_target(y): raise ValueError("continuous target is not supported for classification") - # deterministic init if requested if self.random_state is not None: np.random.seed(self.random_state) torch.manual_seed(self.random_state) - # encode labels to {0,1} and expose classes_ self.classes_, y = np.unique(y, return_inverse=True) self.pipeline_ = self._build_pipeline() @@ -99,5 +96,5 @@ def predict(self, X): check_is_fitted(self) X = validate_data(self, X, reset=False) X = X.astype(np.float32, copy=False) - y01 = self.pipeline_.predict(X).astype(int, copy=False) - return self.classes_[y01] + y = self.pipeline_.predict(X).astype(int, copy=False) + return self.classes_[y] From 1b3e1783353fedc4c4e11e25326a6d7f14b44dcf Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Sun, 10 Aug 2025 17:16:15 +0530 Subject: [PATCH 098/145] Update _feature_classifier.py --- pyaptamer/aptanet/_feature_classifier.py | 2 -- 1 file changed, 2 deletions(-) diff --git a/pyaptamer/aptanet/_feature_classifier.py b/pyaptamer/aptanet/_feature_classifier.py index 8c5ec666..340a08b2 100644 --- a/pyaptamer/aptanet/_feature_classifier.py +++ b/pyaptamer/aptanet/_feature_classifier.py @@ -68,8 +68,6 @@ def _build_pipeline(self): optimizer__alpha=self.alpha, optimizer__eps=self.eps, device="cuda" if torch.cuda.is_available() else "cpu", - train_split=None, - iterator_train__shuffle=False, ) return Pipeline([("select", selector), ("net", net)]) From 28434c9498de2bdb7c099a06bf6b012e1426b58a Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Sun, 10 Aug 2025 22:42:13 +0530 Subject: [PATCH 099/145] Update _feature_classifier.py --- pyaptamer/aptanet/_feature_classifier.py | 5 +++++ 1 file changed, 5 insertions(+) diff --git a/pyaptamer/aptanet/_feature_classifier.py b/pyaptamer/aptanet/_feature_classifier.py index 340a08b2..3b57a336 100644 --- a/pyaptamer/aptanet/_feature_classifier.py +++ b/pyaptamer/aptanet/_feature_classifier.py @@ -96,3 +96,8 @@ def predict(self, X): X = X.astype(np.float32, copy=False) y = self.pipeline_.predict(X).astype(int, copy=False) return self.classes_[y] + + def __sklearn_tags__(self): + tags = super().__sklearn_tags__() + tags.classifier_tags.poor_score = True + return tags From 67ce5bb4c6653454ebbe68e696f7a2fe6139f143 Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Sun, 10 Aug 2025 23:06:39 +0530 Subject: [PATCH 100/145] Added docstrings back --- pyaptamer/aptanet/_feature_classifier.py | 45 +++++++++++++++++++++ pyaptamer/aptanet/_pipeline.py | 51 +++++++++++++++++++++--- 2 files changed, 91 insertions(+), 5 deletions(-) diff --git a/pyaptamer/aptanet/_feature_classifier.py b/pyaptamer/aptanet/_feature_classifier.py index 3b57a336..5567f702 100644 --- a/pyaptamer/aptanet/_feature_classifier.py +++ b/pyaptamer/aptanet/_feature_classifier.py @@ -13,6 +13,51 @@ class AptaNetFeaturesClassifier(ClassifierMixin, BaseEstimator): + """ + Classifier for precomputed numeric features combining RandomForest-based + `SelectFromModel` feature selection with a skorch-wrapped MLP (`AptaNetMLP`). + + This estimator builds an internal sklearn `Pipeline` and delegates `fit`, + `predict`, and other methods to it, while exposing convenient knobs for both + the selector and the neural network. + + References + ---------- + - Emami, N., Ferdousi, R. AptaNet as a deep learning approach for + aptamer–protein interaction prediction. Sci Rep 11, 6074 (2021). + https://doi.org/10.1038/s41598-021-85629-0 + - https://github.com/nedaemami/AptaNet + - https://www.nature.com/articles/s41598-021-85629-0.pdf + + Parameters + ---------- + input_dim : int or None, default=None + Size of the input layer in the neural net. If `None`, it should be + inferred from the feature matrix shape by the underlying module. + hidden_dim : int, default=128 + Number of units in each hidden layer of the neural net. + n_hidden : int, default=7 + Number of hidden layers in the neural net. + dropout : float, default=0.3 + Dropout probability used in the neural net. + max_epochs : int, default=200 + Maximum number of training epochs for the neural net. + lr : float, default=0.00014 + Learning rate for the optimizer (RMSprop). + alpha : float, default=0.9 + Discounting factor (rho) for the squared-gradient moving average in RMSprop. + eps : float, default=1e-08 + Epsilon value for numerical stability in RMSprop. + n_estimators : int, default=300 + Number of trees in the RandomForest used by the feature selector. + max_depth : int, default=9 + Maximum depth of each tree in the RandomForest. + random_state : int or None, default=None + Random seed for reproducibility. When set, both NumPy and Torch seeds are fixed. + threshold : str or float, default="mean" + Threshold passed to `SelectFromModel` (e.g., "mean" or a float). + """ + def __init__( self, input_dim=None, diff --git a/pyaptamer/aptanet/_pipeline.py b/pyaptamer/aptanet/_pipeline.py index 75411036..29435a61 100644 --- a/pyaptamer/aptanet/_pipeline.py +++ b/pyaptamer/aptanet/_pipeline.py @@ -11,11 +11,52 @@ class AptaNetPipeline: """ - Convenience wrapper that accepts **string pairs** (raw aptamer pairs), - converts them to numeric features with `pairs_to_features`, and then - delegates to `AptaNetFeaturesClassifier`. + Pipeline for aptamer-pair classification that starts from **string pairs**, + converts them to numeric features with `pairs_to_features`, then applies + tree-based feature selection and a skorch-wrapped neural network + (`AptaNetFeaturesClassifier`). - This is *not* intended to be run through sklearn's estimator checks. + This class wraps an internal scikit-learn `Pipeline` and delegates `fit`, + `predict`, and related methods to it. + + References + ---------- + - Emami, N., Ferdousi, R. AptaNet as a deep learning approach for + aptamer–protein interaction prediction. Sci Rep 11, 6074 (2021). + https://doi.org/10.1038/s41598-021-85629-0 + - https://github.com/nedaemami/AptaNet + - https://www.nature.com/articles/s41598-021-85629-0.pdf + + Parameters + ---------- + pairs_to_features_kwargs : dict, default=None + Extra keyword arguments passed directly to `pairs_to_features`. + + + - k : int, optional, default=4 + The k-mer size used to generate aptamer k-mer vectors. + - pseaac_kwargs : dict, optional, default=None + Keyword arguments forwarded to PseAAC feature extraction, e.g. + {"lambda_value": 30, "w": 0.05}. + + + **features_classifier_kwargs : dict + Keyword arguments forwarded to `AptaNetFeaturesClassifier` to configure + the feature selector and neural network. See that class’ docstring for + the full list and defaults. + + Examples + -------- + >>> from pyaptamer.aptanet.pipeline import AptaNetPipeline + >>> import numpy as np + >>> pipe = AptaNetPipeline() + >>> aptamer_seq = "AGCTTAGCGTACAGCTTAAAAGGGTTTCCCCTGCCCGCGTAC" + >>> protein_seq = "ACDEFGHIKLMNPQRSTVWYACDEFGHIKLMNPQRSTVWY" + >>> X_train_pairs = [(aptamer_seq, protein_seq) for _ in range(40)] + >>> y_train = np.array([0] * 20 + [1] * 20, dtype=np.float32) + >>> X_test_pairs = [(aptamer_seq, protein_seq) for _ in range(10)] + >>> pipe.fit(X_train_pairs, y_train) + >>> preds = pipe.predict(X_test_pairs) """ def __init__(self, pairs_to_features_kwargs=None, **features_classifier_kwargs): @@ -26,7 +67,7 @@ def _build_pipeline(self): transformer = FunctionTransformer( func=pairs_to_features, kw_args=self.pairs_to_features_kwargs, - validate=False, # allow raw strings through + validate=False, ) clf = AptaNetFeaturesClassifier(**self.features_classifier_kwargs) return Pipeline([("features", transformer), ("clf", clf)]) From 1988408f584c8661d8b398e2d0ca24d9a44b82e4 Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Sun, 10 Aug 2025 23:08:25 +0530 Subject: [PATCH 101/145] Spacing for lists --- pyaptamer/aptanet/_feature_classifier.py | 3 +++ pyaptamer/aptanet/_pipeline.py | 3 +++ 2 files changed, 6 insertions(+) diff --git a/pyaptamer/aptanet/_feature_classifier.py b/pyaptamer/aptanet/_feature_classifier.py index 5567f702..85bcc4a0 100644 --- a/pyaptamer/aptanet/_feature_classifier.py +++ b/pyaptamer/aptanet/_feature_classifier.py @@ -23,12 +23,15 @@ class AptaNetFeaturesClassifier(ClassifierMixin, BaseEstimator): References ---------- + + - Emami, N., Ferdousi, R. AptaNet as a deep learning approach for aptamer–protein interaction prediction. Sci Rep 11, 6074 (2021). https://doi.org/10.1038/s41598-021-85629-0 - https://github.com/nedaemami/AptaNet - https://www.nature.com/articles/s41598-021-85629-0.pdf + Parameters ---------- input_dim : int or None, default=None diff --git a/pyaptamer/aptanet/_pipeline.py b/pyaptamer/aptanet/_pipeline.py index 29435a61..a3ea881a 100644 --- a/pyaptamer/aptanet/_pipeline.py +++ b/pyaptamer/aptanet/_pipeline.py @@ -21,12 +21,15 @@ class AptaNetPipeline: References ---------- + + - Emami, N., Ferdousi, R. AptaNet as a deep learning approach for aptamer–protein interaction prediction. Sci Rep 11, 6074 (2021). https://doi.org/10.1038/s41598-021-85629-0 - https://github.com/nedaemami/AptaNet - https://www.nature.com/articles/s41598-021-85629-0.pdf + Parameters ---------- pairs_to_features_kwargs : dict, default=None From cc645834c22093b575ccc14b4ffb7cbe0d586411 Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Mon, 11 Aug 2025 13:20:48 +0530 Subject: [PATCH 102/145] Update _feature_classifier.py --- pyaptamer/aptanet/_feature_classifier.py | 3 +++ 1 file changed, 3 insertions(+) diff --git a/pyaptamer/aptanet/_feature_classifier.py b/pyaptamer/aptanet/_feature_classifier.py index 85bcc4a0..3f40c2c5 100644 --- a/pyaptamer/aptanet/_feature_classifier.py +++ b/pyaptamer/aptanet/_feature_classifier.py @@ -1,3 +1,6 @@ +__author__ = "satvshr" +__all__ = ["AptaNetFeaturesClassifier"] + import numpy as np import torch import torch.nn as nn From 9f94386a4445cd6cd031f479a96b26bcf8087654 Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Mon, 11 Aug 2025 13:58:10 +0530 Subject: [PATCH 103/145] Update aptanet_tutorial.ipynb --- examples/aptanet_tutorial.ipynb | 487 ++++++++++++++++---------------- 1 file changed, 251 insertions(+), 236 deletions(-) diff --git a/examples/aptanet_tutorial.ipynb b/examples/aptanet_tutorial.ipynb index 763245f3..eef96e46 100644 --- a/examples/aptanet_tutorial.ipynb +++ b/examples/aptanet_tutorial.ipynb @@ -32,26 +32,29 @@ }, { "cell_type": "code", - "execution_count": 14, + "execution_count": 68, "id": "15eabec8", "metadata": {}, "outputs": [], "source": [ "# General imports\n", "import torch # noqa: I001\n", - "import torch.optim as optim\n", "\n", "# Data imports\n", - "from pyaptamer.datasets.loader import load_1gnh_structure\n", + "from pyaptamer.datasets import load_1gnh_structure\n", "from pyaptamer.utils.struct_to_aaseq import struct_to_aaseq\n", "\n", - "# If you want to use the aptamer pipeline, you should use the following imports\n", - "\n", "# If you to build your own aptamer pipeline, you should use the following imports\n", + "from skorch import NeuralNetBinaryClassifier\n", "from sklearn.pipeline import Pipeline\n", "from sklearn.preprocessing import FunctionTransformer\n", - "from pyaptamer.aptanet import FeatureSelector, SkorchAptaNet\n", - "from pyaptamer.utils._aptanet_utils import pairs_to_features" + "from sklearn.ensemble import RandomForestClassifier\n", + "from sklearn.feature_selection import SelectFromModel\n", + "from pyaptamer.utils._aptanet_utils import pairs_to_features\n", + "from pyaptamer.aptanet._aptanet_nn import AptaNetMLP\n", + "\n", + "# If you want to use the AptaNet pipeline, you can import it directly\n", + "from pyaptamer.aptanet._pipeline import AptaNetPipeline" ] }, { @@ -70,12 +73,12 @@ }, { "cell_type": "code", - "execution_count": 15, + "execution_count": 69, "id": "a2f6701d", "metadata": {}, "outputs": [], "source": [ - "aptamer_sequences = [\n", + "aptamer_sequence = [\n", " \"GGGAGGACGAAGACGACUCGAGACAGGCUAGGGAGGGA\",\n", " \"AAGCGUCGGAUCUACACGUGCGAUAGCUCAGUACGCGGU\",\n", " \"CGGUAUCGAGUACAGGAGUCCGACGGAUAGUCCGGAGC\",\n", @@ -86,11 +89,11 @@ "gnh = load_1gnh_structure()\n", "protein_sequence = struct_to_aaseq(gnh)\n", "\n", - "unique_proteins = list(set(protein_sequence))\n", - "unique_aptamers = list(set(aptamer_sequences))\n", + "# unique_proteins = list(set(protein_sequence))\n", + "# unique_aptamers = list(set(aptamer_sequence))\n", "\n", "# Build all combinations (aptamer, protein)\n", - "X = [(a, p) for a in unique_aptamers for p in unique_proteins]\n", + "X = [(a, p) for a in aptamer_sequence for p in protein_sequence]\n", "\n", "# Dummy binary labels for the pairs\n", "y = torch.randint(0, 2, (len(X),), dtype=torch.float32)" @@ -113,7 +116,7 @@ }, { "cell_type": "code", - "execution_count": 16, + "execution_count": 70, "id": "0cf0bed1", "metadata": {}, "outputs": [], @@ -128,26 +131,11 @@ }, { "cell_type": "code", - "execution_count": 17, + "execution_count": 71, "id": "13fb1669", "metadata": {}, "outputs": [], "source": [ - "# Define the classifier\n", - "net = SkorchAptaNet(\n", - " module__hidden_dim=128,\n", - " module__n_hidden=7,\n", - " module__dropout=0.3,\n", - " max_epochs=200,\n", - " lr=1.4e-4,\n", - " batch_size=310,\n", - " optimizer=optim.RMSprop,\n", - " device=\"cuda\" if torch.cuda.is_available() else \"cpu\",\n", - " threshold=0.5,\n", - " train_split=None,\n", - " verbose=1,\n", - ")\n", - "\n", "feature_transformer = FunctionTransformer(\n", " func=pairs_to_features,\n", " validate=False,\n", @@ -156,17 +144,44 @@ " kw_args={},\n", ")\n", "\n", + "selector = SelectFromModel(\n", + " estimator=RandomForestClassifier(\n", + " n_estimators=300,\n", + " max_depth=9,\n", + " random_state=None,\n", + " ),\n", + " threshold=\"mean\",\n", + ")\n", + "\n", + "# Define the classifier\n", + "net = NeuralNetBinaryClassifier(\n", + " module=AptaNetMLP,\n", + " module__input_dim=None,\n", + " module__hidden_dim=128,\n", + " module__n_hidden=7,\n", + " module__dropout=0.3,\n", + " module__output_dim=1,\n", + " module__use_lazy=True,\n", + " criterion=torch.nn.BCEWithLogitsLoss,\n", + " max_epochs=200,\n", + " lr=0.00014,\n", + " optimizer=torch.optim.RMSprop,\n", + " optimizer__alpha=0.9,\n", + " optimizer__eps=1e-08,\n", + " device=\"cuda\" if torch.cuda.is_available() else \"cpu\",\n", + ")\n", + "\n", "# Option 1: build a new pipeline\n", "pipeline = Pipeline(\n", " [\n", " (\"features\", feature_transformer),\n", - " (\"selector\", FeatureSelector()),\n", + " (\"selector\", selector),\n", " (\"clf\", net),\n", " ]\n", ")\n", "\n", "# Option 2: import the pre-defined pipeline (which does the same)\n", - "# pipeline = pipe" + "pipeline = AptaNetPipeline()" ] }, { @@ -181,7 +196,7 @@ }, { "cell_type": "code", - "execution_count": 18, + "execution_count": 72, "id": "1ed76399", "metadata": {}, "outputs": [ @@ -189,208 +204,208 @@ "name": "stdout", "output_type": "stream", "text": [ - " epoch train_loss dur\n", - "------- ------------ ------\n", - " 1 \u001b[36m0.8461\u001b[0m 0.1419\n", - " 2 \u001b[36m0.6572\u001b[0m 0.0161\n", - " 3 0.7241 0.0000\n", - " 4 0.6856 0.0183\n", - " 5 \u001b[36m0.5405\u001b[0m 0.0114\n", - " 6 0.9785 0.0000\n", - " 7 0.8498 0.0159\n", - " 8 0.8247 0.0000\n", - " 9 0.7223 0.0157\n", - " 10 0.6711 0.0000\n", - " 11 0.6652 0.0158\n", - " 12 0.6684 0.0000\n", - " 13 0.7197 0.0158\n", - " 14 0.6808 0.0000\n", - " 15 0.5502 0.0158\n", - " 16 0.7807 0.0000\n", - " 17 0.6591 0.0159\n", - " 18 0.6840 0.0157\n", - " 19 0.6722 0.0000\n", - " 20 0.5827 0.0159\n", - " 21 0.8277 0.0090\n", - " 22 0.6763 0.0000\n", - " 23 0.7158 0.0162\n", - " 24 0.7339 0.0000\n", - " 25 0.7955 0.0152\n", - " 26 0.8719 0.0000\n", - " 27 0.6885 0.0157\n", - " 28 0.6226 0.0000\n", - " 29 0.6545 0.0150\n", - " 30 0.6366 0.0000\n", - " 31 0.6825 0.0158\n", - " 32 0.6082 0.0000\n", - " 33 0.7029 0.0165\n", - " 34 0.7299 0.0154\n", - " 35 0.9808 0.0000\n", - " 36 0.7594 0.0158\n", - " 37 0.8403 0.0039\n", - " 38 0.7218 0.0000\n", - " 39 0.7866 0.0161\n", - " 40 0.6794 0.0000\n", - " 41 0.7263 0.0160\n", - " 42 0.6516 0.0000\n", - " 43 0.6717 0.0158\n", - " 44 0.8348 0.0160\n", - " 45 0.7508 0.0000\n", - " 46 0.9021 0.0000\n", - " 47 0.7072 0.0150\n", - " 48 0.7792 0.0000\n", - " 49 0.7591 0.0159\n", - " 50 0.7266 0.0000\n", - " 51 0.6756 0.0157\n", - " 52 0.6163 0.0000\n", - " 53 0.6225 0.0160\n", - " 54 0.6639 0.0000\n", - " 55 0.7083 0.0159\n", - " 56 0.5963 0.0000\n", - " 57 0.7257 0.0157\n", - " 58 0.6405 0.0056\n", - " 59 0.7366 0.0102\n", - " 60 0.6195 0.0000\n", - " 61 0.7516 0.0158\n", - " 62 0.6718 0.0000\n", - " 63 0.5932 0.0159\n", - " 64 0.8882 0.0000\n", - " 65 0.7327 0.0160\n", - " 66 0.6991 0.0000\n", - " 67 0.6891 0.0157\n", - " 68 0.5933 0.0000\n", - " 69 0.8549 0.0111\n", - " 70 0.8108 0.0000\n", - " 71 \u001b[36m0.5103\u001b[0m 0.0153\n", - " 72 0.6099 0.0000\n", - " 73 0.7089 0.0157\n", - " 74 0.7832 0.0000\n", - " 75 0.8883 0.0000\n", - " 76 0.6810 0.0189\n", - " 77 0.8062 0.0000\n", - " 78 0.7043 0.0000\n", - " 79 0.7434 0.0159\n", - " 80 0.5981 0.0000\n", - " 81 0.8158 0.0176\n", - " 82 0.6205 0.0000\n", - " 83 0.6938 0.0000\n", - " 84 0.5907 0.0158\n", - " 85 0.7626 0.0000\n", - " 86 0.8219 0.0163\n", - " 87 0.8149 0.0000\n", - " 88 0.6653 0.0152\n", - " 89 0.9269 0.0000\n", - " 90 0.6597 0.0000\n", - " 91 0.6851 0.0160\n", - " 92 0.8428 0.0000\n", - " 93 0.8266 0.0160\n", - " 94 0.8843 0.0000\n", - " 95 0.7539 0.0000\n", - " 96 0.8180 0.0158\n", - " 97 0.8543 0.0000\n", - " 98 0.6094 0.0159\n", - " 99 0.7100 0.0000\n", - " 100 0.8850 0.0000\n", - " 101 0.7484 0.0158\n", - " 102 0.7033 0.0000\n", - " 103 0.6150 0.0101\n", - " 104 0.8367 0.0000\n", - " 105 0.5537 0.0000\n", - " 106 0.7578 0.0000\n", - " 107 0.7593 0.0000\n", - " 108 0.8357 0.0158\n", - " 109 0.8099 0.0088\n", - " 110 0.7393 0.0000\n", - " 111 0.6879 0.0000\n", - " 112 0.6998 0.0158\n", - " 113 0.6404 0.0000\n", - " 114 0.6996 0.0159\n", - " 115 0.8520 0.0000\n", - " 116 0.6182 0.0000\n", - " 117 0.6585 0.0179\n", - " 118 0.7316 0.0000\n", - " 119 1.1209 0.0139\n", - " 120 0.8521 0.0000\n", - " 121 0.7580 0.0000\n", - " 122 0.7664 0.0000\n", - " 123 0.6473 0.0000\n", - " 124 0.8394 0.0157\n", - " 125 0.6356 0.0070\n", - " 126 0.8493 0.0106\n", - " 127 0.8244 0.0120\n", - " 128 0.6774 0.0099\n", - " 129 0.6474 0.0085\n", - " 130 0.7050 0.0078\n", - " 131 0.7881 0.0136\n", - " 132 0.5723 0.0080\n", - " 133 0.7643 0.0076\n", - " 134 0.5388 0.0098\n", - " 135 0.7935 0.0080\n", - " 136 0.8746 0.0080\n", - " 137 0.7145 0.0071\n", - " 138 0.7351 0.0096\n", - " 139 0.6367 0.0103\n", - " 140 0.9759 0.0052\n", - " 141 0.5974 0.0126\n", - " 142 0.5716 0.0069\n", - " 143 0.7519 0.0074\n", - " 144 0.7116 0.0011\n", - " 145 0.6647 0.0123\n", - " 146 0.7062 0.0032\n", - " 147 0.7479 0.0000\n", - " 148 0.6261 0.0150\n", - " 149 0.6971 0.0000\n", - " 150 0.7539 0.0166\n", - " 151 0.8594 0.0000\n", - " 152 0.6066 0.0151\n", - " 153 0.8738 0.0016\n", - " 154 0.7141 0.0098\n", - " 155 0.7691 0.0052\n", - " 156 0.7982 0.0094\n", - " 157 0.6404 0.0071\n", - " 158 0.8334 0.0000\n", - " 159 0.7291 0.0151\n", - " 160 0.6554 0.0005\n", - " 161 0.6280 0.0097\n", - " 162 0.6236 0.0077\n", - " 163 0.5305 0.0000\n", - " 164 0.6411 0.0157\n", - " 165 0.6683 0.0000\n", - " 166 0.6695 0.0104\n", - " 167 0.7942 0.0087\n", - " 168 \u001b[36m0.4477\u001b[0m 0.0000\n", - " 169 0.7733 0.0184\n", - " 170 0.7497 0.0042\n", - " 171 0.6720 0.0098\n", - " 172 0.6226 0.0060\n", - " 173 0.5872 0.0061\n", - " 174 0.6602 0.0062\n", - " 175 0.7334 0.0060\n", - " 176 0.7552 0.0074\n", - " 177 0.6609 0.0000\n", - " 178 0.8628 0.0138\n", - " 179 0.6421 0.0000\n", - " 180 0.6228 0.0093\n", - " 181 0.6133 0.0069\n", - " 182 0.7955 0.0098\n", - " 183 0.6620 0.0083\n", - " 184 0.8551 0.0000\n", - " 185 0.6537 0.0054\n", - " 186 0.7264 0.0000\n", - " 187 0.7663 0.0098\n", - " 188 0.7279 0.0010\n", - " 189 0.7689 0.0104\n", - " 190 0.7475 0.0081\n", - " 191 0.7611 0.0000\n", - " 192 0.7346 0.0138\n", - " 193 0.8142 0.0006\n", - " 194 0.7191 0.0095\n", - " 195 0.8565 0.0096\n", - " 196 0.6862 0.0008\n", - " 197 0.6632 0.0129\n", - " 198 0.8455 0.0055\n", - " 199 0.7827 0.0000\n", - " 200 0.8276 0.0149\n" + " epoch train_loss valid_acc valid_loss dur\n", + "------- ------------ ----------- ------------ ------\n", + " 1 \u001b[36m0.7777\u001b[0m \u001b[32m0.5000\u001b[0m \u001b[35m0.6932\u001b[0m 0.0107\n", + " 2 \u001b[36m0.7505\u001b[0m 0.5000 \u001b[35m0.6932\u001b[0m 0.0082\n", + " 3 \u001b[36m0.7306\u001b[0m 0.5000 \u001b[35m0.6932\u001b[0m 0.0098\n", + " 4 0.7702 0.5000 \u001b[35m0.6932\u001b[0m 0.0117\n", + " 5 0.7840 0.5000 \u001b[35m0.6932\u001b[0m 0.0103\n", + " 6 \u001b[36m0.6614\u001b[0m 0.5000 \u001b[35m0.6932\u001b[0m 0.0077\n", + " 7 0.7181 0.5000 \u001b[35m0.6932\u001b[0m 0.0090\n", + " 8 0.7265 0.5000 \u001b[35m0.6932\u001b[0m 0.0123\n", + " 9 0.6886 0.5000 \u001b[35m0.6932\u001b[0m 0.0100\n", + " 10 0.7455 0.5000 0.6932 0.0086\n", + " 11 0.6847 0.5000 \u001b[35m0.6932\u001b[0m 0.0085\n", + " 12 0.7366 0.5000 0.6932 0.0118\n", + " 13 0.6705 0.5000 \u001b[35m0.6932\u001b[0m 0.0112\n", + " 14 0.7077 0.5000 \u001b[35m0.6932\u001b[0m 0.0065\n", + " 15 0.7336 0.5000 \u001b[35m0.6932\u001b[0m 0.0097\n", + " 16 0.7134 0.5000 \u001b[35m0.6932\u001b[0m 0.0111\n", + " 17 0.7668 0.5000 \u001b[35m0.6932\u001b[0m 0.0100\n", + " 18 0.7296 0.5000 \u001b[35m0.6932\u001b[0m 0.0102\n", + " 19 \u001b[36m0.6489\u001b[0m 0.5000 \u001b[35m0.6932\u001b[0m 0.0080\n", + " 20 0.7638 0.5000 \u001b[35m0.6932\u001b[0m 0.0121\n", + " 21 0.7005 0.5000 \u001b[35m0.6932\u001b[0m 0.0110\n", + " 22 0.7522 0.5000 \u001b[35m0.6932\u001b[0m 0.0135\n", + " 23 0.7275 0.5000 \u001b[35m0.6932\u001b[0m 0.0126\n", + " 24 0.7554 0.5000 \u001b[35m0.6932\u001b[0m 0.0095\n", + " 25 0.7553 0.5000 \u001b[35m0.6932\u001b[0m 0.0082\n", + " 26 0.8077 0.5000 \u001b[35m0.6932\u001b[0m 0.0110\n", + " 27 0.7231 0.5000 \u001b[35m0.6932\u001b[0m 0.0120\n", + " 28 0.8158 0.5000 \u001b[35m0.6932\u001b[0m 0.0098\n", + " 29 0.7765 0.5000 \u001b[35m0.6932\u001b[0m 0.0082\n", + " 30 0.7091 0.5000 \u001b[35m0.6932\u001b[0m 0.0107\n", + " 31 0.7092 0.5000 \u001b[35m0.6932\u001b[0m 0.0106\n", + " 32 0.7015 0.5000 \u001b[35m0.6932\u001b[0m 0.0075\n", + " 33 0.7029 0.5000 \u001b[35m0.6932\u001b[0m 0.0093\n", + " 34 0.7200 0.5000 \u001b[35m0.6932\u001b[0m 0.0091\n", + " 35 0.7578 0.5000 \u001b[35m0.6932\u001b[0m 0.0097\n", + " 36 0.7247 0.5000 \u001b[35m0.6932\u001b[0m 0.0080\n", + " 37 0.7285 0.5000 0.6932 0.0137\n", + " 38 0.7258 0.5000 0.6932 0.0124\n", + " 39 0.7568 0.5000 0.6932 0.0145\n", + " 40 0.6936 0.5000 0.6932 0.0105\n", + " 41 0.7253 0.5000 \u001b[35m0.6932\u001b[0m 0.0084\n", + " 42 0.7225 0.5000 \u001b[35m0.6932\u001b[0m 0.0066\n", + " 43 0.7297 0.5000 \u001b[35m0.6932\u001b[0m 0.0117\n", + " 44 0.7041 0.5000 \u001b[35m0.6932\u001b[0m 0.0102\n", + " 45 0.7410 0.5000 0.6932 0.0082\n", + " 46 0.6927 0.5000 \u001b[35m0.6932\u001b[0m 0.0117\n", + " 47 0.7425 0.5000 0.6932 0.0107\n", + " 48 0.6742 0.5000 0.6932 0.0084\n", + " 49 0.7108 0.5000 0.6932 0.0095\n", + " 50 0.7785 0.5000 0.6932 0.0091\n", + " 51 0.7541 0.5000 0.6932 0.0072\n", + " 52 0.7910 0.5000 \u001b[35m0.6932\u001b[0m 0.0121\n", + " 53 0.7094 0.5000 \u001b[35m0.6932\u001b[0m 0.0111\n", + " 54 0.7590 0.5000 \u001b[35m0.6932\u001b[0m 0.0094\n", + " 55 0.6671 0.5000 \u001b[35m0.6932\u001b[0m 0.0105\n", + " 56 0.6936 0.5000 \u001b[35m0.6932\u001b[0m 0.0107\n", + " 57 0.7444 0.5000 \u001b[35m0.6932\u001b[0m 0.0100\n", + " 58 0.8350 0.5000 \u001b[35m0.6932\u001b[0m 0.0117\n", + " 59 0.7264 0.5000 0.6932 0.0079\n", + " 60 0.7017 0.5000 0.6932 0.0134\n", + " 61 0.7242 0.5000 0.6932 0.0120\n", + " 62 0.8309 0.5000 \u001b[35m0.6932\u001b[0m 0.0125\n", + " 63 0.6884 0.5000 \u001b[35m0.6932\u001b[0m 0.0131\n", + " 64 0.7428 0.5000 \u001b[35m0.6932\u001b[0m 0.0067\n", + " 65 0.6931 0.5000 \u001b[35m0.6932\u001b[0m 0.0085\n", + " 66 0.7033 0.5000 \u001b[35m0.6932\u001b[0m 0.0100\n", + " 67 0.7066 0.5000 \u001b[35m0.6932\u001b[0m 0.0080\n", + " 68 0.7317 0.5000 \u001b[35m0.6932\u001b[0m 0.0090\n", + " 69 0.6902 0.5000 \u001b[35m0.6932\u001b[0m 0.0085\n", + " 70 0.7191 0.5000 \u001b[35m0.6931\u001b[0m 0.0110\n", + " 71 0.7122 0.5000 0.6931 0.0082\n", + " 72 0.7619 0.5000 0.6931 0.0115\n", + " 73 0.7577 0.5000 0.6931 0.0092\n", + " 74 0.7609 0.5000 \u001b[35m0.6931\u001b[0m 0.0075\n", + " 75 \u001b[36m0.6298\u001b[0m 0.5000 \u001b[35m0.6931\u001b[0m 0.0070\n", + " 76 0.6581 0.5000 \u001b[35m0.6931\u001b[0m 0.0067\n", + " 77 0.7192 0.5000 \u001b[35m0.6931\u001b[0m 0.0104\n", + " 78 0.7026 0.5000 \u001b[35m0.6931\u001b[0m 0.0098\n", + " 79 0.7158 0.5000 \u001b[35m0.6931\u001b[0m 0.0065\n", + " 80 0.6979 0.5000 0.6931 0.0118\n", + " 81 0.7410 0.5000 \u001b[35m0.6931\u001b[0m 0.0095\n", + " 82 0.7244 0.5000 \u001b[35m0.6931\u001b[0m 0.0066\n", + " 83 0.7550 0.5000 \u001b[35m0.6931\u001b[0m 0.0107\n", + " 84 0.7951 0.5000 \u001b[35m0.6931\u001b[0m 0.0072\n", + " 85 0.7229 0.5000 0.6931 0.0088\n", + " 86 0.6763 0.5000 0.6931 0.0128\n", + " 87 0.7650 0.5000 \u001b[35m0.6931\u001b[0m 0.0110\n", + " 88 0.7654 0.5000 0.6931 0.0077\n", + " 89 0.7280 0.5000 0.6931 0.0076\n", + " 90 0.7321 0.5000 0.6931 0.0110\n", + " 91 0.6994 0.5000 0.6931 0.0061\n", + " 92 0.7845 0.5000 0.6931 0.0100\n", + " 93 0.6848 0.5000 0.6931 0.0112\n", + " 94 0.7239 0.5000 0.6931 0.0130\n", + " 95 0.7249 0.5000 0.6931 0.0096\n", + " 96 0.7749 0.5000 0.6931 0.0078\n", + " 97 0.6518 0.5000 0.6931 0.0084\n", + " 98 0.7710 0.5000 0.6931 0.0073\n", + " 99 0.6791 0.5000 0.6931 0.0116\n", + " 100 0.6953 0.5000 0.6931 0.0083\n", + " 101 0.6896 0.5000 0.6931 0.0065\n", + " 102 0.7170 0.5000 0.6931 0.0077\n", + " 103 0.6947 0.5000 0.6931 0.0080\n", + " 104 0.7427 0.5000 0.6931 0.0080\n", + " 105 0.8014 0.5000 0.6931 0.0090\n", + " 106 0.6914 0.5000 0.6931 0.0080\n", + " 107 0.7150 0.5000 0.6931 0.0092\n", + " 108 0.7232 0.5000 0.6931 0.0105\n", + " 109 0.6514 0.5000 0.6931 0.0076\n", + " 110 0.7675 0.5000 0.6931 0.0077\n", + " 111 0.7852 0.5000 0.6931 0.0081\n", + " 112 0.6864 0.5000 0.6931 0.0088\n", + " 113 0.7327 0.5000 0.6932 0.0090\n", + " 114 0.7318 0.5000 0.6932 0.0057\n", + " 115 0.7218 0.5000 0.6932 0.0070\n", + " 116 0.7339 0.5000 0.6932 0.0083\n", + " 117 0.6934 0.5000 0.6932 0.0080\n", + " 118 0.6926 0.5000 0.6932 0.0101\n", + " 119 0.6669 0.5000 0.6932 0.0122\n", + " 120 0.7895 0.5000 0.6932 0.0063\n", + " 121 0.7360 0.5000 0.6932 0.0075\n", + " 122 0.7070 0.5000 0.6932 0.0061\n", + " 123 0.7256 0.5000 0.6932 0.0085\n", + " 124 0.7705 0.5000 0.6932 0.0090\n", + " 125 0.7052 0.5000 0.6932 0.0075\n", + " 126 0.7018 0.5000 0.6932 0.0097\n", + " 127 0.6779 0.5000 0.6932 0.0111\n", + " 128 0.7723 0.5000 0.6932 0.0078\n", + " 129 0.7693 0.5000 0.6932 0.0081\n", + " 130 0.6365 0.5000 0.6932 0.0088\n", + " 131 0.7420 0.5000 0.6932 0.0080\n", + " 132 0.6870 0.5000 0.6932 0.0108\n", + " 133 0.6986 0.5000 0.6932 0.0132\n", + " 134 0.7707 0.5000 0.6932 0.0084\n", + " 135 0.7500 0.5000 0.6932 0.0101\n", + " 136 0.6913 0.5000 0.6932 0.0097\n", + " 137 0.7393 0.5000 0.6932 0.0090\n", + " 138 0.7299 0.5000 0.6932 0.0090\n", + " 139 0.7371 0.5000 0.6932 0.0077\n", + " 140 \u001b[36m0.6146\u001b[0m 0.5000 0.6932 0.0090\n", + " 141 0.7390 0.5000 0.6932 0.0080\n", + " 142 0.7364 0.5000 0.6932 0.0070\n", + " 143 0.7197 0.5000 0.6932 0.0092\n", + " 144 0.6628 0.5000 0.6932 0.0065\n", + " 145 0.7708 0.5000 0.6932 0.0114\n", + " 146 0.7221 0.5000 0.6932 0.0070\n", + " 147 0.7049 0.5000 0.6932 0.0073\n", + " 148 0.6733 0.5000 0.6932 0.0090\n", + " 149 0.6739 0.5000 0.6932 0.0070\n", + " 150 0.6866 0.5000 0.6932 0.0080\n", + " 151 0.7486 0.5000 0.6932 0.0090\n", + " 152 0.7820 0.5000 0.6932 0.0050\n", + " 153 0.6865 0.5000 0.6932 0.0100\n", + " 154 0.6587 0.5000 0.6932 0.0101\n", + " 155 0.7097 0.5000 0.6932 0.0070\n", + " 156 0.6994 0.5000 0.6932 0.0090\n", + " 157 0.7379 0.5000 0.6932 0.0065\n", + " 158 0.7981 0.5000 0.6932 0.0071\n", + " 159 0.7407 0.5000 0.6932 0.0088\n", + " 160 0.6819 0.5000 0.6932 0.0071\n", + " 161 0.7064 0.5000 0.6932 0.0087\n", + " 162 0.6793 0.5000 0.6932 0.0065\n", + " 163 0.6624 0.5000 0.6932 0.0090\n", + " 164 0.7183 0.5000 0.6932 0.0108\n", + " 165 0.7081 0.5000 0.6932 0.0080\n", + " 166 0.7359 0.5000 0.6932 0.0068\n", + " 167 0.7585 0.5000 0.6932 0.0080\n", + " 168 0.6677 0.5000 0.6932 0.0077\n", + " 169 0.7210 0.5000 0.6932 0.0089\n", + " 170 0.7131 0.5000 0.6932 0.0073\n", + " 171 0.7308 0.5000 0.6932 0.0101\n", + " 172 0.7012 0.5000 0.6932 0.0078\n", + " 173 0.7190 0.5000 0.6932 0.0076\n", + " 174 0.7107 0.5000 0.6932 0.0077\n", + " 175 0.6759 0.5000 0.6932 0.0080\n", + " 176 0.6838 0.5000 0.6932 0.0086\n", + " 177 0.6782 0.5000 0.6932 0.0056\n", + " 178 0.7783 0.5000 0.6932 0.0080\n", + " 179 0.7546 0.5000 0.6932 0.0092\n", + " 180 0.7283 0.5000 0.6932 0.0070\n", + " 181 0.7226 0.5000 0.6932 0.0098\n", + " 182 0.7194 0.5000 0.6932 0.0070\n", + " 183 0.6914 0.5000 0.6932 0.0097\n", + " 184 0.8147 0.5000 0.6932 0.0080\n", + " 185 0.7383 0.5000 0.6932 0.0078\n", + " 186 0.6586 0.5000 0.6932 0.0087\n", + " 187 0.6708 0.5000 0.6932 0.0076\n", + " 188 0.7220 0.5000 0.6932 0.0071\n", + " 189 0.7123 0.5000 0.6932 0.0092\n", + " 190 0.7841 0.5000 0.6932 0.0070\n", + " 191 0.7738 0.5000 0.6932 0.0080\n", + " 192 0.6898 0.5000 0.6932 0.0075\n", + " 193 0.7703 0.5000 0.6932 0.0070\n", + " 194 0.6941 0.5000 0.6932 0.0111\n", + " 195 0.6681 0.5000 0.6932 0.0081\n", + " 196 0.7413 0.5000 0.6932 0.0088\n", + " 197 0.7506 0.5000 0.6932 0.0106\n", + " 198 0.7331 0.5000 0.6932 0.0078\n", + " 199 0.6821 0.5000 0.6932 0.0090\n", + " 200 0.7131 0.5000 0.6932 0.0098\n" ] } ], @@ -404,7 +419,7 @@ }, { "cell_type": "code", - "execution_count": 19, + "execution_count": 73, "id": "945dc876", "metadata": {}, "outputs": [ @@ -412,7 +427,7 @@ "name": "stdout", "output_type": "stream", "text": [ - "Training Accuracy: 0.6\n" + "Training Accuracy: 0.52\n" ] } ], From 08297c0770280a1b1f45dbb26c2d0c7c3f598bb5 Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Mon, 11 Aug 2025 13:58:26 +0530 Subject: [PATCH 104/145] Update aptanet_tutorial.ipynb --- examples/aptanet_tutorial.ipynb | 5 +---- 1 file changed, 1 insertion(+), 4 deletions(-) diff --git a/examples/aptanet_tutorial.ipynb b/examples/aptanet_tutorial.ipynb index eef96e46..72d458ee 100644 --- a/examples/aptanet_tutorial.ipynb +++ b/examples/aptanet_tutorial.ipynb @@ -73,7 +73,7 @@ }, { "cell_type": "code", - "execution_count": 69, + "execution_count": null, "id": "a2f6701d", "metadata": {}, "outputs": [], @@ -89,9 +89,6 @@ "gnh = load_1gnh_structure()\n", "protein_sequence = struct_to_aaseq(gnh)\n", "\n", - "# unique_proteins = list(set(protein_sequence))\n", - "# unique_aptamers = list(set(aptamer_sequence))\n", - "\n", "# Build all combinations (aptamer, protein)\n", "X = [(a, p) for a in aptamer_sequence for p in protein_sequence]\n", "\n", From bc8355ffd9c5e798c8439863da7bfe2b3c05fc15 Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Mon, 11 Aug 2025 14:07:45 +0530 Subject: [PATCH 105/145] Update aptanet_tutorial.ipynb --- examples/aptanet_tutorial.ipynb | 4 ++-- 1 file changed, 2 insertions(+), 2 deletions(-) diff --git a/examples/aptanet_tutorial.ipynb b/examples/aptanet_tutorial.ipynb index 72d458ee..dbae7b41 100644 --- a/examples/aptanet_tutorial.ipynb +++ b/examples/aptanet_tutorial.ipynb @@ -32,7 +32,7 @@ }, { "cell_type": "code", - "execution_count": 68, + "execution_count": null, "id": "15eabec8", "metadata": {}, "outputs": [], @@ -54,7 +54,7 @@ "from pyaptamer.aptanet._aptanet_nn import AptaNetMLP\n", "\n", "# If you want to use the AptaNet pipeline, you can import it directly\n", - "from pyaptamer.aptanet._pipeline import AptaNetPipeline" + "from pyaptamer.aptanet import AptaNetPipeline" ] }, { From 5882b24484729abbe5f6215a899a769be5d1f146 Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Mon, 11 Aug 2025 19:06:11 +0530 Subject: [PATCH 106/145] Update aptanet_tutorial.ipynb --- examples/aptanet_tutorial.ipynb | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/examples/aptanet_tutorial.ipynb b/examples/aptanet_tutorial.ipynb index dbae7b41..d8dac11f 100644 --- a/examples/aptanet_tutorial.ipynb +++ b/examples/aptanet_tutorial.ipynb @@ -68,7 +68,7 @@ " * 5 random aptamer sequences of length>30 (to satisfy the default lambda value of 30 set in the PSeAAC algorithm).\n", " * Amino-acid sequences extracted from the 1GNH protein molecule.\n", "* As `y`:\n", - " * A random binary value (0/1) equal to the number of `(aptamer_seq, protein_seq)` pairs as dummy data." + " * A random binary value (0/1) equal to the number of `(aptamer_seq, protein_seq)` pairs as dummy data." ] }, { From 183c48b3378cfcb65abfaad0b3c56776b18837be Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Tue, 12 Aug 2025 21:58:18 +0530 Subject: [PATCH 107/145] Made requested and architectural changes --- pyaptamer/aptanet/__init__.py | 3 +- pyaptamer/aptanet/_feature_classifier.py | 41 ++++++++++--------- pyaptamer/aptanet/_pipeline.py | 52 +++++++++++------------- pyaptamer/aptanet/tests/test_aptanet.py | 5 +-- pyaptamer/utils/_aptanet_utils.py | 9 +--- 5 files changed, 51 insertions(+), 59 deletions(-) diff --git a/pyaptamer/aptanet/__init__.py b/pyaptamer/aptanet/__init__.py index fb10818c..9986cdc9 100644 --- a/pyaptamer/aptanet/__init__.py +++ b/pyaptamer/aptanet/__init__.py @@ -1,5 +1,6 @@ """The AptaNet algorithm""" +from pyaptamer.aptanet._feature_classifier import AptaNetClassifier from pyaptamer.aptanet._pipeline import AptaNetPipeline -__all__ = ["AptaNetPipeline"] +__all__ = ["AptaNetPipeline", "AptaNetClassifier"] diff --git a/pyaptamer/aptanet/_feature_classifier.py b/pyaptamer/aptanet/_feature_classifier.py index 3f40c2c5..7f8ccbe6 100644 --- a/pyaptamer/aptanet/_feature_classifier.py +++ b/pyaptamer/aptanet/_feature_classifier.py @@ -1,10 +1,10 @@ __author__ = "satvshr" -__all__ = ["AptaNetFeaturesClassifier"] +__all__ = ["AptaNetClassifier"] import numpy as np import torch import torch.nn as nn -from sklearn.base import BaseEstimator, ClassifierMixin +from sklearn.base import BaseEstimator, ClassifierMixin, clone from sklearn.ensemble import RandomForestClassifier from sklearn.feature_selection import SelectFromModel from sklearn.pipeline import Pipeline @@ -15,12 +15,14 @@ from pyaptamer.aptanet._aptanet_nn import AptaNetMLP -class AptaNetFeaturesClassifier(ClassifierMixin, BaseEstimator): +class AptaNetClassifier(ClassifierMixin, BaseEstimator): """ - Classifier for precomputed numeric features combining RandomForest-based - `SelectFromModel` feature selection with a skorch-wrapped MLP (`AptaNetMLP`). + This estimator applies a tree-based `SelectFromModel` using a RandomForest + to filter input features, then trains a skorch-wrapped multi-layer perceptron + (`AptaNetMLP`) with BCE-with-logits. This mirrors the AptaNet-style deep + model used for aptamer–protein interaction prediction. - This estimator builds an internal sklearn `Pipeline` and delegates `fit`, + This classifier builds an internal sklearn `Pipeline` and delegates `fit`, `predict`, and other methods to it, while exposing convenient knobs for both the selector and the neural network. @@ -54,14 +56,14 @@ class AptaNetFeaturesClassifier(ClassifierMixin, BaseEstimator): Discounting factor (rho) for the squared-gradient moving average in RMSprop. eps : float, default=1e-08 Epsilon value for numerical stability in RMSprop. - n_estimators : int, default=300 - Number of trees in the RandomForest used by the feature selector. - max_depth : int, default=9 - Maximum depth of each tree in the RandomForest. + estimator : sklearn estimator or None, default=None + Estimator used for feature selection. If `None`, a `RandomForestClassifier`. random_state : int or None, default=None Random seed for reproducibility. When set, both NumPy and Torch seeds are fixed. threshold : str or float, default="mean" Threshold passed to `SelectFromModel` (e.g., "mean" or a float). + verbose : int, default=0 + Verbosity level for the underlying skorch `NeuralNetBinaryClassifier`. """ def __init__( @@ -74,10 +76,10 @@ def __init__( lr=0.00014, alpha=0.9, eps=1e-08, - n_estimators=300, - max_depth=9, + estimator=None, random_state=None, threshold="mean", + verbose=0, ): self.input_dim = input_dim self.hidden_dim = hidden_dim @@ -87,20 +89,20 @@ def __init__( self.lr = lr self.alpha = alpha self.eps = eps - self.n_estimators = n_estimators - self.max_depth = max_depth + self.estimator = estimator self.random_state = random_state self.threshold = threshold + self.verbose = verbose def _build_pipeline(self): from skorch import NeuralNetBinaryClassifier + base_estimator = self.estimator or RandomForestClassifier( + n_estimators=300, max_depth=9, random_state=self.random_state + ) + selector = SelectFromModel( - estimator=RandomForestClassifier( - n_estimators=self.n_estimators, - max_depth=self.max_depth, - random_state=self.random_state, - ), + estimator=clone(base_estimator), threshold=self.threshold, ) @@ -119,6 +121,7 @@ def _build_pipeline(self): optimizer__alpha=self.alpha, optimizer__eps=self.eps, device="cuda" if torch.cuda.is_available() else "cpu", + verbose=self.verbose, ) return Pipeline([("select", selector), ("net", net)]) diff --git a/pyaptamer/aptanet/_pipeline.py b/pyaptamer/aptanet/_pipeline.py index a3ea881a..465169d5 100644 --- a/pyaptamer/aptanet/_pipeline.py +++ b/pyaptamer/aptanet/_pipeline.py @@ -1,23 +1,28 @@ __author__ = "satvshr" __all__ = ["AptaNetPipeline"] -__required__ = ["python>=3.9,<3.12"] +__required__ = ["python>=3.9,<3.13"] +from sklearn.base import clone from sklearn.pipeline import Pipeline from sklearn.preprocessing import FunctionTransformer -from pyaptamer.aptanet._feature_classifier import AptaNetFeaturesClassifier +from pyaptamer.aptanet import AptaNetClassifier from pyaptamer.utils._aptanet_utils import pairs_to_features class AptaNetPipeline: """ - Pipeline for aptamer-pair classification that starts from **string pairs**, - converts them to numeric features with `pairs_to_features`, then applies - tree-based feature selection and a skorch-wrapped neural network - (`AptaNetFeaturesClassifier`). + AptaNetPipeline: AptaNet algorithm for aptamer–protein interaction + prediction (Emami et al., 2021) - This class wraps an internal scikit-learn `Pipeline` and delegates `fit`, - `predict`, and related methods to it. + Implements the AptaNet algorithm, a deep learning method that combines + sequence-derived features with RandomForest-based feature selection and a + multi-layer perceptron to predict whether an aptamer and a protein interact + (binary classification). + + The pipeline starts from string pairs, converts them into numeric features + (aptamer k-mer frequencies + protein PSeAAC), applies tree-based feature + selection, and feeds the result into the classifier. References ---------- @@ -32,25 +37,15 @@ class AptaNetPipeline: Parameters ---------- - pairs_to_features_kwargs : dict, default=None - Extra keyword arguments passed directly to `pairs_to_features`. - - - - k : int, optional, default=4 + k : int, optional, default=4 The k-mer size used to generate aptamer k-mer vectors. - - pseaac_kwargs : dict, optional, default=None - Keyword arguments forwarded to PseAAC feature extraction, e.g. - {"lambda_value": 30, "w": 0.05}. - - **features_classifier_kwargs : dict - Keyword arguments forwarded to `AptaNetFeaturesClassifier` to configure - the feature selector and neural network. See that class’ docstring for - the full list and defaults. + classifier : sklearn-compatible estimator or None, default=None + Estimator applied after feature selection. If None, uses `AptaNetClassifier`. Examples -------- - >>> from pyaptamer.aptanet.pipeline import AptaNetPipeline + >>> from pyaptamer.aptanet import AptaNetPipeline >>> import numpy as np >>> pipe = AptaNetPipeline() >>> aptamer_seq = "AGCTTAGCGTACAGCTTAAAAGGGTTTCCCCTGCCCGCGTAC" @@ -58,22 +53,21 @@ class AptaNetPipeline: >>> X_train_pairs = [(aptamer_seq, protein_seq) for _ in range(40)] >>> y_train = np.array([0] * 20 + [1] * 20, dtype=np.float32) >>> X_test_pairs = [(aptamer_seq, protein_seq) for _ in range(10)] - >>> pipe.fit(X_train_pairs, y_train) + >>> pipe.fit(X_train_pairs, y_train) # doctest: +ELLIPSIS >>> preds = pipe.predict(X_test_pairs) """ - def __init__(self, pairs_to_features_kwargs=None, **features_classifier_kwargs): - self.pairs_to_features_kwargs = pairs_to_features_kwargs - self.features_classifier_kwargs = features_classifier_kwargs + def __init__(self, k=None, classifier=None): + self.k = k + self.classifier = classifier or AptaNetClassifier() def _build_pipeline(self): transformer = FunctionTransformer( func=pairs_to_features, - kw_args=self.pairs_to_features_kwargs, + kw_args=self.k, validate=False, ) - clf = AptaNetFeaturesClassifier(**self.features_classifier_kwargs) - return Pipeline([("features", transformer), ("clf", clf)]) + return Pipeline([("features", transformer), ("clf", clone(self.classifier))]) def fit(self, X, y): self.pipeline_ = self._build_pipeline() diff --git a/pyaptamer/aptanet/tests/test_aptanet.py b/pyaptamer/aptanet/tests/test_aptanet.py index 773b2c07..9b72ef89 100644 --- a/pyaptamer/aptanet/tests/test_aptanet.py +++ b/pyaptamer/aptanet/tests/test_aptanet.py @@ -4,8 +4,7 @@ import pytest from sklearn.utils.estimator_checks import parametrize_with_checks -from pyaptamer.aptanet import AptaNetPipeline -from pyaptamer.aptanet._pipeline import AptaNetFeaturesClassifier +from pyaptamer.aptanet import AptaNetClassifier, AptaNetPipeline @pytest.mark.skipif( @@ -39,7 +38,7 @@ def test_pipeline_fit_and_predict(aptamer_seq, protein_seq): @pytest.mark.skipif( sys.version_info >= (3, 13), reason="skorch does not support Python 3.13" ) -@parametrize_with_checks([AptaNetFeaturesClassifier()]) +@parametrize_with_checks([AptaNetClassifier()]) def test_sklearn_compatible_estimator(estimator, check): """ Run scikit-learn's compatibility checks on the AptaPipeline. diff --git a/pyaptamer/utils/_aptanet_utils.py b/pyaptamer/utils/_aptanet_utils.py index d0fb4d97..6cad920d 100644 --- a/pyaptamer/utils/_aptanet_utils.py +++ b/pyaptamer/utils/_aptanet_utils.py @@ -53,7 +53,7 @@ def generate_kmer_vecs(aptamer_sequence, k=4): return kmer_freq -def pairs_to_features(X, k=4, pseaac_kwargs=None): +def pairs_to_features(X, k=4): """ Convert a list of (aptamer_sequence, protein_sequence) pairs into feature vectors. @@ -75,18 +75,13 @@ def pairs_to_features(X, k=4, pseaac_kwargs=None): The k-mer size used to generate the k-mer vector from the aptamer sequence. Default is 4. - pseaac_kwargs : dict, optional - Optional keyword arguments to pass to the `PSeAAC` transformer. - If not provided, default parameters are used. - Returns ------- np.ndarray A 2D NumPy array where each row corresponds to the concatenated feature vector for a given (aptamer, protein) pair. """ - pseaac_kwargs = {} if pseaac_kwargs is None else pseaac_kwargs - pseaac = PSeAAC(**pseaac_kwargs) + pseaac = PSeAAC() feats = [] for aptamer_seq, protein_seq in X: From e5b1dddb7488f032c20b1b6dda7998d846ae7030 Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Fri, 15 Aug 2025 02:08:12 +0530 Subject: [PATCH 108/145] Update pyproject.toml --- pyproject.toml | 3 +-- 1 file changed, 1 insertion(+), 2 deletions(-) diff --git a/pyproject.toml b/pyproject.toml index 446cca45..d72ef734 100644 --- a/pyproject.toml +++ b/pyproject.toml @@ -27,8 +27,7 @@ dependencies = [ dev = [ "ruff>=0.12.0", "pytest>=8.0.0", - "pre-commit", - "biopython>=1.83" + "pre-commit" ] [tool.ruff] From 84eefa190bd4ab17271b4136bb766d698950f074 Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Fri, 15 Aug 2025 12:06:13 +0530 Subject: [PATCH 109/145] Delete one_gnh.py --- pyaptamer/datasets/_loaders/one_gnh.py | 25 ------------------------- 1 file changed, 25 deletions(-) delete mode 100644 pyaptamer/datasets/_loaders/one_gnh.py diff --git a/pyaptamer/datasets/_loaders/one_gnh.py b/pyaptamer/datasets/_loaders/one_gnh.py deleted file mode 100644 index bdddb796..00000000 --- a/pyaptamer/datasets/_loaders/one_gnh.py +++ /dev/null @@ -1,25 +0,0 @@ -import os - -from Bio.PDB import PDBParser - - -def load_1gnh_structure(pdb_path=None): - """ - Load the 1gnh molecule from a PDB file using Biopython. - - Parameters - ---------- - pdb_path : str, optional - Path to the PDB file. If not provided, the function uses the default path - located in the '../data/1gnh.pdb' relative to the current file. - - Returns - ------- - structure : Bio.PDB.Structure.Structure - A Biopython Structure object representing the PFOA molecule. - """ - pdb_path = os.path.join(os.path.dirname(__file__), "..", "data", "1gnh.pdb") - - parser = PDBParser(QUIET=True) - structure = parser.get_structure("1gnh", pdb_path) - return structure From 1c78a4b71fb15f697130d2fc679030ccdd70bebc Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Sun, 17 Aug 2025 18:18:43 +0530 Subject: [PATCH 110/145] Update pyproject.toml --- pyproject.toml | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/pyproject.toml b/pyproject.toml index d72ef734..e5e803fc 100644 --- a/pyproject.toml +++ b/pyproject.toml @@ -27,7 +27,7 @@ dependencies = [ dev = [ "ruff>=0.12.0", "pytest>=8.0.0", - "pre-commit" + "pre-commit", ] [tool.ruff] From d9a5df980f81e503be34cf83e6fe336ba495bad5 Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Wed, 20 Aug 2025 01:58:08 +0530 Subject: [PATCH 111/145] Update aptanet_tutorial.ipynb --- examples/aptanet_tutorial.ipynb | 20 ++++++++++---------- 1 file changed, 10 insertions(+), 10 deletions(-) diff --git a/examples/aptanet_tutorial.ipynb b/examples/aptanet_tutorial.ipynb index d8dac11f..fdb81b6b 100644 --- a/examples/aptanet_tutorial.ipynb +++ b/examples/aptanet_tutorial.ipynb @@ -44,6 +44,9 @@ "from pyaptamer.datasets import load_1gnh_structure\n", "from pyaptamer.utils.struct_to_aaseq import struct_to_aaseq\n", "\n", + "# If you want to use the AptaNet pipeline, you can import it directly\n", + "from pyaptamer.aptanet import AptaNetPipeline\n", + "\n", "# If you to build your own aptamer pipeline, you should use the following imports\n", "from skorch import NeuralNetBinaryClassifier\n", "from sklearn.pipeline import Pipeline\n", @@ -51,10 +54,7 @@ "from sklearn.ensemble import RandomForestClassifier\n", "from sklearn.feature_selection import SelectFromModel\n", "from pyaptamer.utils._aptanet_utils import pairs_to_features\n", - "from pyaptamer.aptanet._aptanet_nn import AptaNetMLP\n", - "\n", - "# If you want to use the AptaNet pipeline, you can import it directly\n", - "from pyaptamer.aptanet import AptaNetPipeline" + "from pyaptamer.aptanet._aptanet_nn import AptaNetMLP" ] }, { @@ -128,11 +128,15 @@ }, { "cell_type": "code", - "execution_count": 71, + "execution_count": null, "id": "13fb1669", "metadata": {}, "outputs": [], "source": [ + "# Option 1: import the pre-defined pipeline (which does the same)\n", + "pipeline = AptaNetPipeline()\n", + "\n", + "# Option 2: build a new pipeline\n", "feature_transformer = FunctionTransformer(\n", " func=pairs_to_features,\n", " validate=False,\n", @@ -168,17 +172,13 @@ " device=\"cuda\" if torch.cuda.is_available() else \"cpu\",\n", ")\n", "\n", - "# Option 1: build a new pipeline\n", "pipeline = Pipeline(\n", " [\n", " (\"features\", feature_transformer),\n", " (\"selector\", selector),\n", " (\"clf\", net),\n", " ]\n", - ")\n", - "\n", - "# Option 2: import the pre-defined pipeline (which does the same)\n", - "pipeline = AptaNetPipeline()" + ")" ] }, { From 55dcb861b1041e6769ced778cf03c67720ef3e30 Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Wed, 20 Aug 2025 17:00:14 +0530 Subject: [PATCH 112/145] Added workflows --- examples/aptanet_tutorial.ipynb | 468 +++++++++++++++++--------------- pyproject.toml | 3 +- 2 files changed, 256 insertions(+), 215 deletions(-) diff --git a/examples/aptanet_tutorial.ipynb b/examples/aptanet_tutorial.ipynb index fdb81b6b..285faa3e 100644 --- a/examples/aptanet_tutorial.ipynb +++ b/examples/aptanet_tutorial.ipynb @@ -49,7 +49,6 @@ "\n", "# If you to build your own aptamer pipeline, you should use the following imports\n", "from skorch import NeuralNetBinaryClassifier\n", - "from sklearn.pipeline import Pipeline\n", "from sklearn.preprocessing import FunctionTransformer\n", "from sklearn.ensemble import RandomForestClassifier\n", "from sklearn.feature_selection import SelectFromModel\n", @@ -73,7 +72,7 @@ }, { "cell_type": "code", - "execution_count": null, + "execution_count": 2, "id": "a2f6701d", "metadata": {}, "outputs": [], @@ -108,22 +107,59 @@ " Neighborhood Cleaning Rule to balance the classes.\n", "2. Get the PSeAAC feature vectors for your converted input (using `pairs_to_features`).\n", "3. Select the number of features to use from the feature vector (using `FeatureSelector`).\n", - "4. Define the skorch neural network (using `SkorchAptaNet`)." + "4. Define the skorch neural network (using `AptaNetMLP`)." + ] + }, + { + "cell_type": "markdown", + "id": "c10ae4ea", + "metadata": {}, + "source": [ + "## Different workflows\n", + "In this notebook we will cover 2 different workflows one can follow, in ascending order of customizability:\n", + "\n", + "1. A minimal workflow with no dataset balancing, while using the in-built pipeline.\n", + "3. Dataset balancing using under-sampling, while using your own pipeline." + ] + }, + { + "cell_type": "markdown", + "id": "5b7c1997", + "metadata": {}, + "source": [ + "### First workflow\n", + "A minimal workflow with no dataset balancing, while using the in-built pipeline." + ] + }, + { + "cell_type": "code", + "execution_count": 3, + "id": "d782bca8", + "metadata": {}, + "outputs": [], + "source": [ + "pipeline = AptaNetPipeline()" + ] + }, + { + "cell_type": "markdown", + "id": "37db693e", + "metadata": {}, + "source": [ + "### Second workflow\n", + "Dataset balancing using under-sampling, while using your own pipeline." ] }, { "cell_type": "code", - "execution_count": 70, + "execution_count": null, "id": "0cf0bed1", "metadata": {}, "outputs": [], "source": [ "# OPTIONAL: If you want to use the Neighborhood Cleaning Rule for under-sampling\n", "# %pip install imblearn\n", - "# from imblearn.under_sampling import NeighbourhoodCleaningRule\n", - "\n", - "# ncr = NeighbourhoodCleaningRule()\n", - "# X, y = ncr.fit_resample(X, y)" + "from imblearn.under_sampling import NeighbourhoodCleaningRule # noqa: E402" ] }, { @@ -133,10 +169,12 @@ "metadata": {}, "outputs": [], "source": [ - "# Option 1: import the pre-defined pipeline (which does the same)\n", + "# NOTE: If you want to use the under-sampling, you need to install imbalanced-learn\n", + "# and use the Pipeline from imblearn\n", + "from imblearn.pipeline import Pipeline\n", + "\n", "pipeline = AptaNetPipeline()\n", "\n", - "# Option 2: build a new pipeline\n", "feature_transformer = FunctionTransformer(\n", " func=pairs_to_features,\n", " validate=False,\n", @@ -175,6 +213,8 @@ "pipeline = Pipeline(\n", " [\n", " (\"features\", feature_transformer),\n", + " # Optional under-sampling, use sklearn's Pipeline if you do not need it\n", + " (\"ncr\", NeighbourhoodCleaningRule()),\n", " (\"selector\", selector),\n", " (\"clf\", net),\n", " ]\n", @@ -193,7 +233,7 @@ }, { "cell_type": "code", - "execution_count": 72, + "execution_count": 6, "id": "1ed76399", "metadata": {}, "outputs": [ @@ -203,206 +243,206 @@ "text": [ " epoch train_loss valid_acc valid_loss dur\n", "------- ------------ ----------- ------------ ------\n", - " 1 \u001b[36m0.7777\u001b[0m \u001b[32m0.5000\u001b[0m \u001b[35m0.6932\u001b[0m 0.0107\n", - " 2 \u001b[36m0.7505\u001b[0m 0.5000 \u001b[35m0.6932\u001b[0m 0.0082\n", - " 3 \u001b[36m0.7306\u001b[0m 0.5000 \u001b[35m0.6932\u001b[0m 0.0098\n", - " 4 0.7702 0.5000 \u001b[35m0.6932\u001b[0m 0.0117\n", - " 5 0.7840 0.5000 \u001b[35m0.6932\u001b[0m 0.0103\n", - " 6 \u001b[36m0.6614\u001b[0m 0.5000 \u001b[35m0.6932\u001b[0m 0.0077\n", - " 7 0.7181 0.5000 \u001b[35m0.6932\u001b[0m 0.0090\n", - " 8 0.7265 0.5000 \u001b[35m0.6932\u001b[0m 0.0123\n", - " 9 0.6886 0.5000 \u001b[35m0.6932\u001b[0m 0.0100\n", - " 10 0.7455 0.5000 0.6932 0.0086\n", - " 11 0.6847 0.5000 \u001b[35m0.6932\u001b[0m 0.0085\n", - " 12 0.7366 0.5000 0.6932 0.0118\n", - " 13 0.6705 0.5000 \u001b[35m0.6932\u001b[0m 0.0112\n", - " 14 0.7077 0.5000 \u001b[35m0.6932\u001b[0m 0.0065\n", - " 15 0.7336 0.5000 \u001b[35m0.6932\u001b[0m 0.0097\n", - " 16 0.7134 0.5000 \u001b[35m0.6932\u001b[0m 0.0111\n", - " 17 0.7668 0.5000 \u001b[35m0.6932\u001b[0m 0.0100\n", - " 18 0.7296 0.5000 \u001b[35m0.6932\u001b[0m 0.0102\n", - " 19 \u001b[36m0.6489\u001b[0m 0.5000 \u001b[35m0.6932\u001b[0m 0.0080\n", - " 20 0.7638 0.5000 \u001b[35m0.6932\u001b[0m 0.0121\n", - " 21 0.7005 0.5000 \u001b[35m0.6932\u001b[0m 0.0110\n", - " 22 0.7522 0.5000 \u001b[35m0.6932\u001b[0m 0.0135\n", - " 23 0.7275 0.5000 \u001b[35m0.6932\u001b[0m 0.0126\n", - " 24 0.7554 0.5000 \u001b[35m0.6932\u001b[0m 0.0095\n", - " 25 0.7553 0.5000 \u001b[35m0.6932\u001b[0m 0.0082\n", - " 26 0.8077 0.5000 \u001b[35m0.6932\u001b[0m 0.0110\n", - " 27 0.7231 0.5000 \u001b[35m0.6932\u001b[0m 0.0120\n", - " 28 0.8158 0.5000 \u001b[35m0.6932\u001b[0m 0.0098\n", - " 29 0.7765 0.5000 \u001b[35m0.6932\u001b[0m 0.0082\n", - " 30 0.7091 0.5000 \u001b[35m0.6932\u001b[0m 0.0107\n", - " 31 0.7092 0.5000 \u001b[35m0.6932\u001b[0m 0.0106\n", - " 32 0.7015 0.5000 \u001b[35m0.6932\u001b[0m 0.0075\n", - " 33 0.7029 0.5000 \u001b[35m0.6932\u001b[0m 0.0093\n", - " 34 0.7200 0.5000 \u001b[35m0.6932\u001b[0m 0.0091\n", - " 35 0.7578 0.5000 \u001b[35m0.6932\u001b[0m 0.0097\n", - " 36 0.7247 0.5000 \u001b[35m0.6932\u001b[0m 0.0080\n", - " 37 0.7285 0.5000 0.6932 0.0137\n", - " 38 0.7258 0.5000 0.6932 0.0124\n", - " 39 0.7568 0.5000 0.6932 0.0145\n", - " 40 0.6936 0.5000 0.6932 0.0105\n", - " 41 0.7253 0.5000 \u001b[35m0.6932\u001b[0m 0.0084\n", - " 42 0.7225 0.5000 \u001b[35m0.6932\u001b[0m 0.0066\n", - " 43 0.7297 0.5000 \u001b[35m0.6932\u001b[0m 0.0117\n", - " 44 0.7041 0.5000 \u001b[35m0.6932\u001b[0m 0.0102\n", - " 45 0.7410 0.5000 0.6932 0.0082\n", - " 46 0.6927 0.5000 \u001b[35m0.6932\u001b[0m 0.0117\n", - " 47 0.7425 0.5000 0.6932 0.0107\n", - " 48 0.6742 0.5000 0.6932 0.0084\n", - " 49 0.7108 0.5000 0.6932 0.0095\n", - " 50 0.7785 0.5000 0.6932 0.0091\n", - " 51 0.7541 0.5000 0.6932 0.0072\n", - " 52 0.7910 0.5000 \u001b[35m0.6932\u001b[0m 0.0121\n", - " 53 0.7094 0.5000 \u001b[35m0.6932\u001b[0m 0.0111\n", - " 54 0.7590 0.5000 \u001b[35m0.6932\u001b[0m 0.0094\n", - " 55 0.6671 0.5000 \u001b[35m0.6932\u001b[0m 0.0105\n", - " 56 0.6936 0.5000 \u001b[35m0.6932\u001b[0m 0.0107\n", - " 57 0.7444 0.5000 \u001b[35m0.6932\u001b[0m 0.0100\n", - " 58 0.8350 0.5000 \u001b[35m0.6932\u001b[0m 0.0117\n", - " 59 0.7264 0.5000 0.6932 0.0079\n", - " 60 0.7017 0.5000 0.6932 0.0134\n", - " 61 0.7242 0.5000 0.6932 0.0120\n", - " 62 0.8309 0.5000 \u001b[35m0.6932\u001b[0m 0.0125\n", - " 63 0.6884 0.5000 \u001b[35m0.6932\u001b[0m 0.0131\n", - " 64 0.7428 0.5000 \u001b[35m0.6932\u001b[0m 0.0067\n", - " 65 0.6931 0.5000 \u001b[35m0.6932\u001b[0m 0.0085\n", - " 66 0.7033 0.5000 \u001b[35m0.6932\u001b[0m 0.0100\n", - " 67 0.7066 0.5000 \u001b[35m0.6932\u001b[0m 0.0080\n", - " 68 0.7317 0.5000 \u001b[35m0.6932\u001b[0m 0.0090\n", - " 69 0.6902 0.5000 \u001b[35m0.6932\u001b[0m 0.0085\n", - " 70 0.7191 0.5000 \u001b[35m0.6931\u001b[0m 0.0110\n", - " 71 0.7122 0.5000 0.6931 0.0082\n", - " 72 0.7619 0.5000 0.6931 0.0115\n", - " 73 0.7577 0.5000 0.6931 0.0092\n", - " 74 0.7609 0.5000 \u001b[35m0.6931\u001b[0m 0.0075\n", - " 75 \u001b[36m0.6298\u001b[0m 0.5000 \u001b[35m0.6931\u001b[0m 0.0070\n", - " 76 0.6581 0.5000 \u001b[35m0.6931\u001b[0m 0.0067\n", - " 77 0.7192 0.5000 \u001b[35m0.6931\u001b[0m 0.0104\n", - " 78 0.7026 0.5000 \u001b[35m0.6931\u001b[0m 0.0098\n", - " 79 0.7158 0.5000 \u001b[35m0.6931\u001b[0m 0.0065\n", - " 80 0.6979 0.5000 0.6931 0.0118\n", - " 81 0.7410 0.5000 \u001b[35m0.6931\u001b[0m 0.0095\n", - " 82 0.7244 0.5000 \u001b[35m0.6931\u001b[0m 0.0066\n", - " 83 0.7550 0.5000 \u001b[35m0.6931\u001b[0m 0.0107\n", - " 84 0.7951 0.5000 \u001b[35m0.6931\u001b[0m 0.0072\n", - " 85 0.7229 0.5000 0.6931 0.0088\n", - " 86 0.6763 0.5000 0.6931 0.0128\n", - " 87 0.7650 0.5000 \u001b[35m0.6931\u001b[0m 0.0110\n", - " 88 0.7654 0.5000 0.6931 0.0077\n", - " 89 0.7280 0.5000 0.6931 0.0076\n", - " 90 0.7321 0.5000 0.6931 0.0110\n", - " 91 0.6994 0.5000 0.6931 0.0061\n", - " 92 0.7845 0.5000 0.6931 0.0100\n", - " 93 0.6848 0.5000 0.6931 0.0112\n", - " 94 0.7239 0.5000 0.6931 0.0130\n", - " 95 0.7249 0.5000 0.6931 0.0096\n", - " 96 0.7749 0.5000 0.6931 0.0078\n", - " 97 0.6518 0.5000 0.6931 0.0084\n", - " 98 0.7710 0.5000 0.6931 0.0073\n", - " 99 0.6791 0.5000 0.6931 0.0116\n", - " 100 0.6953 0.5000 0.6931 0.0083\n", - " 101 0.6896 0.5000 0.6931 0.0065\n", - " 102 0.7170 0.5000 0.6931 0.0077\n", - " 103 0.6947 0.5000 0.6931 0.0080\n", - " 104 0.7427 0.5000 0.6931 0.0080\n", - " 105 0.8014 0.5000 0.6931 0.0090\n", - " 106 0.6914 0.5000 0.6931 0.0080\n", - " 107 0.7150 0.5000 0.6931 0.0092\n", - " 108 0.7232 0.5000 0.6931 0.0105\n", - " 109 0.6514 0.5000 0.6931 0.0076\n", - " 110 0.7675 0.5000 0.6931 0.0077\n", - " 111 0.7852 0.5000 0.6931 0.0081\n", - " 112 0.6864 0.5000 0.6931 0.0088\n", - " 113 0.7327 0.5000 0.6932 0.0090\n", - " 114 0.7318 0.5000 0.6932 0.0057\n", - " 115 0.7218 0.5000 0.6932 0.0070\n", - " 116 0.7339 0.5000 0.6932 0.0083\n", - " 117 0.6934 0.5000 0.6932 0.0080\n", - " 118 0.6926 0.5000 0.6932 0.0101\n", - " 119 0.6669 0.5000 0.6932 0.0122\n", - " 120 0.7895 0.5000 0.6932 0.0063\n", - " 121 0.7360 0.5000 0.6932 0.0075\n", - " 122 0.7070 0.5000 0.6932 0.0061\n", - " 123 0.7256 0.5000 0.6932 0.0085\n", - " 124 0.7705 0.5000 0.6932 0.0090\n", - " 125 0.7052 0.5000 0.6932 0.0075\n", - " 126 0.7018 0.5000 0.6932 0.0097\n", - " 127 0.6779 0.5000 0.6932 0.0111\n", - " 128 0.7723 0.5000 0.6932 0.0078\n", - " 129 0.7693 0.5000 0.6932 0.0081\n", - " 130 0.6365 0.5000 0.6932 0.0088\n", - " 131 0.7420 0.5000 0.6932 0.0080\n", - " 132 0.6870 0.5000 0.6932 0.0108\n", - " 133 0.6986 0.5000 0.6932 0.0132\n", - " 134 0.7707 0.5000 0.6932 0.0084\n", - " 135 0.7500 0.5000 0.6932 0.0101\n", - " 136 0.6913 0.5000 0.6932 0.0097\n", - " 137 0.7393 0.5000 0.6932 0.0090\n", - " 138 0.7299 0.5000 0.6932 0.0090\n", - " 139 0.7371 0.5000 0.6932 0.0077\n", - " 140 \u001b[36m0.6146\u001b[0m 0.5000 0.6932 0.0090\n", - " 141 0.7390 0.5000 0.6932 0.0080\n", - " 142 0.7364 0.5000 0.6932 0.0070\n", - " 143 0.7197 0.5000 0.6932 0.0092\n", - " 144 0.6628 0.5000 0.6932 0.0065\n", - " 145 0.7708 0.5000 0.6932 0.0114\n", - " 146 0.7221 0.5000 0.6932 0.0070\n", - " 147 0.7049 0.5000 0.6932 0.0073\n", - " 148 0.6733 0.5000 0.6932 0.0090\n", - " 149 0.6739 0.5000 0.6932 0.0070\n", - " 150 0.6866 0.5000 0.6932 0.0080\n", - " 151 0.7486 0.5000 0.6932 0.0090\n", - " 152 0.7820 0.5000 0.6932 0.0050\n", - " 153 0.6865 0.5000 0.6932 0.0100\n", - " 154 0.6587 0.5000 0.6932 0.0101\n", - " 155 0.7097 0.5000 0.6932 0.0070\n", - " 156 0.6994 0.5000 0.6932 0.0090\n", - " 157 0.7379 0.5000 0.6932 0.0065\n", - " 158 0.7981 0.5000 0.6932 0.0071\n", - " 159 0.7407 0.5000 0.6932 0.0088\n", - " 160 0.6819 0.5000 0.6932 0.0071\n", - " 161 0.7064 0.5000 0.6932 0.0087\n", - " 162 0.6793 0.5000 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0.6279 0.7143 \u001b[35m0.6524\u001b[0m 0.0062\n", + " 193 0.5838 0.7143 \u001b[35m0.6520\u001b[0m 0.0073\n", + " 194 0.5488 0.7143 \u001b[35m0.6516\u001b[0m 0.0055\n", + " 195 0.6394 0.7143 \u001b[35m0.6511\u001b[0m 0.0065\n", + " 196 0.6153 0.7143 \u001b[35m0.6508\u001b[0m 0.0075\n", + " 197 0.6353 0.7143 \u001b[35m0.6505\u001b[0m 0.0060\n", + " 198 0.6536 0.7143 \u001b[35m0.6500\u001b[0m 0.0063\n", + " 199 0.6070 0.7143 \u001b[35m0.6497\u001b[0m 0.0055\n", + " 200 0.5572 0.7143 \u001b[35m0.6493\u001b[0m 0.0065\n" ] } ], @@ -416,7 +456,7 @@ }, { "cell_type": "code", - "execution_count": 73, + "execution_count": 7, "id": "945dc876", "metadata": {}, "outputs": [ @@ -424,7 +464,7 @@ "name": "stdout", "output_type": "stream", "text": [ - "Training Accuracy: 0.52\n" + "Training Accuracy: 0.48\n" ] } ], @@ -438,7 +478,7 @@ ], "metadata": { "kernelspec": { - "display_name": "pyaptamer", + "display_name": "pyaptamer-latest", "language": "python", "name": "python3" }, diff --git a/pyproject.toml b/pyproject.toml index e5e803fc..e4c44b95 100644 --- a/pyproject.toml +++ b/pyproject.toml @@ -20,7 +20,8 @@ dependencies = [ "scikit-base", "torch>=2.5.1", "scikit-learn>=1.3.0", - "skorch" + "skorch", + "imblearn", ] [project.optional-dependencies] From bce4cd1f75b2e6129fc0ad1601cde9138626cb3b Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Sat, 23 Aug 2025 19:12:32 +0530 Subject: [PATCH 113/145] Getting aptanet ready --- pyaptamer/aptanet/_feature_classifier.py | 71 +- pyaptamer/benchmarking/__init__.py | 1 + pyaptamer/benchmarking/_base.py | 21 + pyaptamer/datasets/data/train_li2014.csv | 2321 ++++++++++++++++++++++ pyaptamer/utils/tag_checks.py | 5 + x.py | 4 + 6 files changed, 2401 insertions(+), 22 deletions(-) create mode 100644 pyaptamer/benchmarking/__init__.py create mode 100644 pyaptamer/benchmarking/_base.py create mode 100644 pyaptamer/datasets/data/train_li2014.csv create mode 100644 pyaptamer/utils/tag_checks.py create mode 100644 x.py diff --git a/pyaptamer/aptanet/_feature_classifier.py b/pyaptamer/aptanet/_feature_classifier.py index 7f8ccbe6..578211a1 100644 --- a/pyaptamer/aptanet/_feature_classifier.py +++ b/pyaptamer/aptanet/_feature_classifier.py @@ -1,5 +1,5 @@ __author__ = "satvshr" -__all__ = ["AptaNetClassifier"] +__all__ = ["AptaNetPredictor"] import numpy as np import torch @@ -13,16 +13,17 @@ from torch import optim from pyaptamer.aptanet._aptanet_nn import AptaNetMLP +from pyaptamer.utils.tag_checks import task_check -class AptaNetClassifier(ClassifierMixin, BaseEstimator): +class AptaNetPredictor(ClassifierMixin, BaseEstimator): """ This estimator applies a tree-based `SelectFromModel` using a RandomForest to filter input features, then trains a skorch-wrapped multi-layer perceptron - (`AptaNetMLP`) with BCE-with-logits. This mirrors the AptaNet-style deep + (`AptaNetMLP`) with BCE-with-logits (default). This mirrors the AptaNet-style deep model used for aptamer–protein interaction prediction. - This classifier builds an internal sklearn `Pipeline` and delegates `fit`, + This predictor builds an internal sklearn `Pipeline` and delegates `fit`, `predict`, and other methods to it, while exposing convenient knobs for both the selector and the neural network. @@ -39,6 +40,8 @@ class AptaNetClassifier(ClassifierMixin, BaseEstimator): Parameters ---------- + task : str, default="classification" + Task type, either "classification" or "regression". input_dim : int or None, default=None Size of the input layer in the neural net. If `None`, it should be inferred from the feature matrix shape by the underlying module. @@ -66,8 +69,11 @@ class AptaNetClassifier(ClassifierMixin, BaseEstimator): Verbosity level for the underlying skorch `NeuralNetBinaryClassifier`. """ + _tags = {"tasks": ["classification", "regression"]} + def __init__( self, + task="classification", input_dim=None, hidden_dim=128, n_hidden=7, @@ -81,6 +87,7 @@ def __init__( threshold="mean", verbose=0, ): + self.task = task self.input_dim = input_dim self.hidden_dim = hidden_dim self.n_hidden = n_hidden @@ -93,9 +100,10 @@ def __init__( self.random_state = random_state self.threshold = threshold self.verbose = verbose + task_check(self) def _build_pipeline(self): - from skorch import NeuralNetBinaryClassifier + from skorch import NeuralNetBinaryClassifier, NeuralNetRegressor base_estimator = self.estimator or RandomForestClassifier( n_estimators=300, max_depth=9, random_state=self.random_state @@ -106,23 +114,42 @@ def _build_pipeline(self): threshold=self.threshold, ) - net = NeuralNetBinaryClassifier( - module=AptaNetMLP, - module__input_dim=self.input_dim, - module__hidden_dim=self.hidden_dim, - module__n_hidden=self.n_hidden, - module__dropout=self.dropout, - module__output_dim=1, - module__use_lazy=True, - criterion=nn.BCEWithLogitsLoss, - max_epochs=self.max_epochs, - lr=self.lr, - optimizer=optim.RMSprop, - optimizer__alpha=self.alpha, - optimizer__eps=self.eps, - device="cuda" if torch.cuda.is_available() else "cpu", - verbose=self.verbose, - ) + if self.task == "classification": + net = NeuralNetBinaryClassifier( + module=AptaNetMLP, + module__input_dim=self.input_dim, + module__hidden_dim=self.hidden_dim, + module__n_hidden=self.n_hidden, + module__dropout=self.dropout, + module__output_dim=1, + module__use_lazy=True, + criterion=nn.BCEWithLogitsLoss, + max_epochs=self.max_epochs, + lr=self.lr, + optimizer=optim.RMSprop, + optimizer__alpha=self.alpha, + optimizer__eps=self.eps, + device="cuda" if torch.cuda.is_available() else "cpu", + verbose=self.verbose, + ) + else: + net = NeuralNetRegressor( + module=AptaNetMLP, + module__input_dim=self.input_dim, + module__hidden_dim=self.hidden_dim, + module__n_hidden=self.n_hidden, + module__dropout=self.dropout, + module__output_dim=1, + module__use_lazy=True, + criterion=nn.MSELoss, + max_epochs=self.max_epochs, + lr=self.lr, + optimizer=optim.RMSprop, + optimizer__alpha=self.alpha, + optimizer__eps=self.eps, + device="cuda" if torch.cuda.is_available() else "cpu", + verbose=self.verbose, + ) return Pipeline([("select", selector), ("net", net)]) diff --git a/pyaptamer/benchmarking/__init__.py b/pyaptamer/benchmarking/__init__.py new file mode 100644 index 00000000..403026e7 --- /dev/null +++ b/pyaptamer/benchmarking/__init__.py @@ -0,0 +1 @@ +"""Benchmarking module.""" diff --git a/pyaptamer/benchmarking/_base.py b/pyaptamer/benchmarking/_base.py new file mode 100644 index 00000000..06b2a1ca --- /dev/null +++ b/pyaptamer/benchmarking/_base.py @@ -0,0 +1,21 @@ +from pyaptamer.utils.tag_checks import task_check + + +class Benchmark: + """Base class for benchmarking different estimators on various datasets.""" + + _tags = {"tasks": ["classification", "regression"]} + + def __init__(self, estimators, dataset_Loaders, evaluators, task): + self.estimators = [estimators] + self.dataset_Loaders = [dataset_Loaders] + self.evaluators = [evaluators] + self.task = task + task_check(self) + + def run(self): + results = {} + for _estimator in self.estimators: + for dataset_Loader in self.dataset_Loaders: + dataset_name = dataset_Loader.id + results[dataset_name] = {} diff --git a/pyaptamer/datasets/data/train_li2014.csv b/pyaptamer/datasets/data/train_li2014.csv new file mode 100644 index 00000000..fb32a968 --- /dev/null +++ b/pyaptamer/datasets/data/train_li2014.csv @@ -0,0 +1,2321 @@ +aptamer,protein,label +UCGGAGGUGGUUCAGCUCUGCAUCGACAGUUGGC,MDSTNYISKLFEYAQRQGQISDIKFEEVGTDGPDHLKTFTLRVVIKGHAYPNGVGKTKKEAKRNAAKHALIGMMETTEQKDASVSCPPSPAPSPAPPVRAVISQPKYVSWLNEHSQKNKLSLKALEGARVGPNNTSQCCRYVVGEKEYPEGFGNTKKEAKEEAAMQVYLELCGGSQTTGTVDENCNGTTGKHKEELNGKVVVLSEKVEHMNMSPAQNVPEQYSFITTEETNFIGILNHYCQKTKRFLDFKLVEKSGPSHNPQFVYKVLIDKREYPDGLGKTAKEAKQQAAQLAWSALQEQSDWNSQVSCRSTVSEEGGLSSLTPSSTWESQDATPSSLSIAGSTSESIIFSDSVNVSSPKDESPVNVKPKIRLAANFQMSPVKTKQEGPNLKGNDLGTLSSGRTSNQPVISRFSSEFDSIENIGKGGFGHVYKARRKLEQKYFAVKIVRSKGKAKREVGALADLQHPNIVRYYTAWLEDTAYRCDTASESDTTSDSGSSSSSEFLYIQMELCDKRTLKVWIDERNAHRKPKRREESLSITQQIVNGVEYIHSKKLLHRDLKPANIMFGMSDGEGKGEVKIGDFGLVTAEDNDNDENLLERTKKTGTVSYMAPEQRNQTSYDRKVDIFALGLIYFEPLWDLSGMEKAKVWNDVRSQRFPQQFNSQFTLENKVIESLLCANPEERPDARQLKTKLNECSRVLTRVHNIHQDNRTI,positive +CGGGGTGTTGTCCTGTGCTCTCCGGAGAGCACAGGACAACACCCCG,MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINYDEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQAVAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQGIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADMDFSALLSQISS,positive +GCTGCAGTTGCACTGAATTCGCCTCTCGCCTCCGTACACTTAGTCGACAGGATCCGCTGAACTGACCTG,MDEVGAQVAAPMFIHQSLGRKRDLYYPMSNRLVQSQPQRRDEWNSKMWDWDSRRFEAKPVDVEVQEFDLTLRNRSGEERGLDLNLGSGLTAVEETTTTTQNVRPNKKVRSGSPGGNYPMCQVDNCTEDLSHAKDYHRRHKVCEVHSKATKALVGKQMQRFCQQCSRFHLLSEFDEGKRSCRRRLAGHNRRRRKTTQPEEVASGVVVPGNHDTTNNTANANMDLMALLTALACAQGKNAVKPPVGSPAVPDREQLLQILNKINALPLPMDLVSKLNNIGSLARKNMDHPTVNPQNDMNGASPSTMDLLAVLSTTLGSSSPDALAILSQGGFGNKDSEKTKLSSYENGVTTNLEKRTFGFSSVGGERSSSSNQSPSQDSDSRGQDTRSSLSLQLFTSSPEDESRPTVASSRKYYSSASSNPVEDRSPSSSPVMQELFPLQASPETMRSKNHKNSSPRTGCLPLELFGASNRGAADPNFKGFGQQSGYASSGSDYSPPSLNSDAQDRTGKIVFKLLDKDPSQLPGTLRSEIYNWLSNIPSEMESYIRPGCVVLSVYVAMSPAAWEQLEQKLLQRLGVLLQNSPSDFWRNARFIVNTGRQLASHKNGKVRCSKSWRTWNSPELISVSPVAVVAGEETSLVVRGRSLTNDGISIRCTHMGSYMAMEVTRAVCRQTIFDELNVNSFKVQNVHPGFLGRCFIEVENGFRGDSFPLIIANASICKELNRLGEEFHPKSQDMTEEQAQSSNRGPTSREEVLCFLNELGWLFQKNQTSELREQSDFSLARFKFLLVCSVERDYCALIRTLLDMLVERNLVNDELNREALDMLAEIQLLNRAVKRKSTKMVELLIHYLVNPLTLSSSRKFVFLPNITGPGGITPLHLAACTSGSDDMIDLLTNDPQEIGLSSWNTLRDATGQTPYSYAAIRNNHNYNSLVARKLADKRNKQVSLNIEHEVVDQTGLSKRLSLEMNKSSSSCASCATVALKYQRRVSGSQRLFPTPIIHSMLAVATVCVCVCVFMHAFPIVRQGSHFSWGGLDYGSI,positive +TATTTGCCCTTGCAGGCCGCAGGAGTGCTAGCAGT,PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGKISKIGPENPYNTPVFAIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDESFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPXRXKNPEMVIYQYMDDLYVGSDLEIGQHRAKIEELRSHLLSWGFTTPDKKHQKEPPFLWMGYELHPDSWTVQPIELPEKDSWTVNE,positive +UCUCUGGGCUCUUAGGAGAACGGAUAGGAGUGUGCUCGCU,LQENFLPQPRQQHHGTLVLHYRPHREEAGMQHPCLWPGSSHCSDDSTLRRLQCESVTSIGAVCP,positive +GGGAGACAAGAAUAAACGCUCAACACAGAACGCGGUCCCCACACAGGACAGGAGCCAGCCCCGGUUCGUCAGGAGGCUCACAACAGGC,MACAAARSPADQDRFICIYPAYLNNKKTIAEGRRIPISKAVENPTATEIQDVCSAVGLNVFLEKNKMYSREWNRDVQYRGRVRVQLKQEDGSLCLVQFPSRKSVMLYAAEMIPKLKTRTQKTGGADQSLQQGEGSKKGKGKKKK,positive +CTTCTGCCCGCCTCCTTCCGTTTTCCTGCGGCAGCGTTTTGTTGCTTTCGTTCCTCCGGGAGACGAGATAGGCGGACACT,MEGMLKGEGPGPLPPLLQQYVELRDQYPDYLLLFQVGDFYECFGEDAERLARALGLVLTHKTSKDFTTPMAGIPLRAFEAYAERLLKMGFRLAVADQVEPAEEAEGLVRREVTQLLTPGTLLQESLLPREANYLAAIATGDGWGLAFLDVSTGEFKGTVLKSKSALYDELFRHRPAEVLLAPELLENGAFLDEFRKRFPVMLSEAPFEPEGEGPLALRRARGALLAYAQRTQGGALSLQPFRFYDPGAFMRLPEATLRALEVFEPLRGQDTLFSVLDETRTAPGRRLLQSWLRHPLLDRGPLEARLDRVEGFVREGALREGVRRLLYRLADLERLATRLELGRASPKDLGALRRSLQILPELRALLGEEVGLPDLSPLKEELEAALVEDPPLKVSEGGLIREGYDPDLDALRAAHREGVAYFLELEERERERTGIPTLKVGYNAVFGYYLEVTRPYYERVPKEYRPVQTLKDRQRYTLPEMKEKEREVYRLEALIRRREEEVFLEVRERAKRQAEALREAARILAELDVYAALAEVAVRYGYVRPRFGDRLQIRAGRHPVVERRTEFVPNDLEMAHELVLITGPNMAGKSTFLRQTALIALLAQVGSFVPAEEAHLPLFDGIYTRIGASDDLAGGKSTFMVEMEEVALILKEATENSLVLLDEVGRGTSSLDGVAIATAVAEALHERRAYTLFATHYFELTALGLPRLKNLHVAAREEAGGLVFYHQVLPGPASKSYGVEVAAMAGLPKEVVARARALLQAMAARREGALDAVLERLLALDPDRLTPLEALRLLQELKALALGAPLDTMKG,positive +CACCUACUAGACCACUUUUUGAGCCGGUUUUUUCGGGAACUUGCCAA,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,positive +GCAACAGAGGCUGAUGGUAGACGCCGGCCA,MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPGPHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR,positive +ACGAAACCUGCAGUCCUGCAAUGGGACAAG,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,positive +GGGAGGACGCGUCGCCGUAAUGGAUGUUUUGCUCCCUG,EFPPSTFYRVTLYGLYKGELLDPVFAEAITEAEPEVEHITVSDITPHSFKVTWTAPEAVFDSFALKVLDSSGLGRPHQISVSGDKRTEAVTGLNEDTDYEIELFGIILGRKFQPIFTVARTGLGTRKGIRFSDVTDTSATVHWTMPHTRVDNYRVIYVPIQGGSPLTLRVDGGESQAMLSNLTPGVTYQVTVIAVKGLEESEPGSERVTTALDKPRGLTAVNISDTEALLLWQPSIATVDGYVITYSADSVAPVMERVSGNTVEFEMSSLTPATLYTVKVYAFRDTAKSAATSTDFTTDVDAPQNLAASNIQTETAMLTWKPPRADISGYILSFESADGVVKEVVLSPTATFYSMSHLTASTEYTVKLQAIAGPKRSRVISTVFLTIGVLYKHPKDCSQALLNGDTTSGFYTIYLRGDESQPLQVYCDMTTDGGGWIVFVRRQSGKVEFFRNWKNYTAGFGDLNDEFWLGLSNLHKITSFGQYELRVDLRDKGESAYAQYDKFSISEPRARYKVHVGGYSGTAGDSMTYHHGRPFSTYDNDNDIAVTNCALSYKGAFWYKNCHRVNIMGRYGDNSHSKGVNWFHWKGHEHSVEFAEMKIRPANFRNFEGRKKRS,positive +CGTGTCGTATTGAGTGATATGATGCACATA,MDKLVVNYYEYKHPIINKDLAIGAHGGKKFPTLGAWYDVINEYEFQTRCPIILKNSHRNKHFTFACHLKNCPFKVLLSYAGNAASSETSSPSANNNTNPPGTPDHIHHHSNNMNNEDNDNNNGSNNKVSNDSKLDFVTDDLEYHLANTHPDDTNDKVESRSNEVNGNNDDDADANNIFKQQGVTIKNDTEDDSINKASIDRGLDDESGPTHGNDSGNHRHNEEDDVHTQMTKNYSDVVNDEDINVAIANAVANVDSQSNNKHDGKDDDATNNNDGQDNNTNNDHNNNSNINNNNVGSHGISSHSPSSIRDTSMNLDVFNSATDDIPGPFVVTKIEPYHSHPLEDNLSLGKFILTKIPKILQNDLKFDQILESSYNNSNHTVSKFKVSHYVEESGLLDILMQRYGLTAEDFEKRLLSQIARRITTYKARFVLKKKKMGEYNDLQPSSSSNNNNNNDGELSGTNLRSNSIDYAKHQEISSAGTSSNTTKNVNNNKNDSNDDNNGNNNNDASNLMESVLDKTSSHRYQPKKMPSVNKWSKPDQITHSDVSMVGLDESNDGGNENVHPTLAEVDAQEARETAQLAIDKINSYKRSIDDKNGDGHNNSSRNVVDENLINDMDSEDAHKSKRQHLSDITLEERNEDDKLPHEVAEQLRLLSSHLKEVENLHQNNDDDVDDVMVDVDVESQYNKNTTHHNNHHSQPHHDEEDVAGLIGKADDEEDLSDENIQPELRGQ,positive +GUCGAGACAUAAGAAACAAGAAGAUCCUGAAACUGUUUUAAGGUUGGCCGAUCUUCUGCUCGAGAAUGCAUGAAAGCGUU,XQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGSTGSPGPGYGYSNYGFPPYGGITFHPGVTKSNAGVTHGTINTKFKNGPKDCAKSDDEESLTLPEKETEGEGPSLPMACTKTEPIALASTMEDKEQDMGFQDNLFLEKALQLARRHANALFDYAVTGDVKMLLAVQRHLTAVQDENGDSVLHLAIIHLHAQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRVGADLSLLDRWGNSVLHLAAKEGHDRILSILLKSRKAAPLIDHPNGEGLNAIHIAVMSNSLPCLLLLVAAGAEVNAQEQKSGRTALHLAVEYDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWEKAGEDEGVVPGTTPLDMAANWQVFDILNGKPYEPVFTSDDILPQGDMKQLTEDTRLQLCKLLEIPDPDKNWATLAQKLGLGILNNAFRLSPAPSKTLMDNYEMNSGIVTASVTVVWRHPSANSALQSLLLETAHCYL,positive +GGGUUACCUAGGUGUAGAUGCUCACUUACACAAACCUGUAGUUUUAUGCUUCACAUAUCGCACAGGACGCUUAAGUGACGUCUGAACUGCUUCGAA,PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGKISKIGPENPYNTPVFAIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDESFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPXRXKNPEMVIYQYMDDLYVGSDLEIGQHRAKIEELRSHLLSWGFTTPDKKHQKEPPFLWMGYELHPDSWTVQPIELPEKDSWTVNE,positive +UAUCCUCCAGAGCAUCGCCGUCCAUAACCACUUACCUCCU,MGVLLTQRTLLSLVLALLFPSMASMAAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQGLDVPKLREHCRERPGAFPSEETLRGLGRRGFLQTLNATLGCVLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILGLRNNIYCMAQLLDNSDTAEPTKAGRGASQPPTPTPASDAFQRKLEGCRFLHGYHRFMHSVGRVFSKWGESPNRSRRHSPHQALRKGVRRTRPSRKGKRLMTRGQLPR,positive +GGTTGTGAAGATTGGGAGCGTCGTGGCTAC,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,positive +UGGUAGGACGGCACCGGAGAAAGGUAGCAUGAUAAGCGAGUACCUGCCGU,MSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEMLDRHHTHFCPLEGESWQDFLRNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAFLCQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERETPTTDSMPPLLRQAIELFDHQGAEPAFLFGLELIICGLEKQLKCESGS,positive +AGACCUUAUACCUGAGAUUACACGCUCUUCGAGCACGUCGAC,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,positive +TCCCACGCATTCTCCACATCGAGGAGTATCGGGGCACGATCCTATTTAAGGCCGATAACCCCTTTCTGTCCTTCCGTCAC,MSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA,positive +GCGUGCAGUGCCUUCGGCCGTGCGGTGCCUCCGUCACGCT,MLPWTALGLALSLRLALARSGAERGPPASAPRGDLMFLLDSSASVSHYEFSRVREFVGQLVAPLPLGTGALRASLVHVGSRPYTEFPFGQHSSGEAAQDAVRASAQRMGDTHTGLALVYAKEQLFAEASGARPGVPKVLVWVTDGGSSDPVGPPMQELKDLGVTVFIVSTGRGNFLELSAAASAPAEKHLHFVDVDDLHIIVQELRGSILDAMRPQQLHATEITSSGFRLAWPPLLTADSGYYVLELVPSAQPGAARRQQLPGNATDWIWAGLDPDTDYDVALVPESNVRLLRPQILRVRTRPGEAGPGASGPESGAGPAPTQLAALPAPEEAGPERIVISHARPRSLRVSWAPALGSAAALGYHVQFGPLRGGEAQRVEVPAGRNCTTLQGLAPGTAYLVTVTAAFRSGRESALSAKACTPDGPRPRPRPVPRAPTPGTASREP,positive +GGCUUAGCUAAACGUAGCGGGUAUCGAACGCGAGCGGCAUGCCGAUAUCAUGAGUAGCCGUGAUAGCAUGCUGCUCGGAUAAGCA,XQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGSTGSPGPGYGYSNYGFPPYGGITFHPGVTKSNAGVTHGTINTKFKNGPKDCAKSDDEESLTLPEKETEGEGPSLPMACTKTEPIALASTMEDKEQDMGFQDNLFLEKALQLARRHANALFDYAVTGDVKMLLAVQRHLTAVQDENGDSVLHLAIIHLHAQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRVGADLSLLDRWGNSVLHLAAKEGHDRILSILLKSRKAAPLIDHPNGEGLNAIHIAVMSNSLPCLLLLVAAGAEVNAQEQKSGRTALHLAVEYDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWEKAGEDEGVVPGTTPLDMAANWQVFDILNGKPYEPVFTSDDILPQGDMKQLTEDTRLQLCKLLEIPDPDKNWATLAQKLGLGILNNAFRLSPAPSKTLMDNYEMNSGIVTASVTVVWRHPSANSALQSLLLETAHCYL,positive +AATAGCCCCCCTTCGGTGCAAAGCACCGAAGGGGGGC,WPLTEEKIKALVEICXEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEEFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDXIIYQYMDDLYVGSDLEIGQHRTKVEELRQHLLXWGFTTPDKKHQKEPPFLWMGYELHP,positive +GGGAGAAGGGAAGTAACAGGGUGGGUCUCCGCAUUUGUGCUUCGAUCCGGUGAGAAGAGGTGACGGTACCAG,QELLCAASLISDRWVLTAAHCLLYPPWDKNFTVNDILVRIGKYARSRYERNMEKISTLEKIIIHPGYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDKQIVTSLLQAGHKGRVTGWGNLKEMWTVNMNEVQPSVLQMVNLPLVERPICKASTGIRVTDNMFCAGYKPEEGKRGDACEGDSGGPFVMKNPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIRKMVDRFG,positive +TCCCACGCATTCTCCACATCAAGTGGGGCACCAGGTTTGGTCCCCGGATAGGGGCCACTTCCTTTCTGTCCTTCCGTCAC,MSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA,positive +GGGAGCTCAGAATAAACGCTCAACGGTGGTGGGTGGGATGAAGAATGGAGAGGGGTTCGACATGAGGCCCGGATC,MLNQLDNLTERVRGSNKLVDRWLHVRKHLLVAYYNLVGIKPGKESYMRLNEKALDDFCQSLVDYLSAGHFSIYERILHKLEGNGQLARAAKIWPQLEANTQQIMDYYDSSLETAIDHDNYLEFQQVLSDIGEALEARFVLEDKLILLVLDAARVKHPA,positive +CGTACCAAGATCCCACAACTAGCCGACCACAATTGCCGGC,MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA,positive +AGAGAGAAAGCCAACCATAGCAAATGATACGGAGATTTTG,MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQRGLKNVFDEAILAALEPPETQPKRKCCIF,positive +GCAGAGAAAGGGUAAGUAUGAUGUCUACCGGAAUGUGUGGGCUUGGUGCG,MSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEMLDRHHTHFCPLEGESWQDFLRNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAFLCQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERETPTTDSMPPLLRQAIELFDHQGAEPAFLFGLELIICGLEKQLKCESGS,positive +CTTTTATAGGATCGCACCTATGAATCTAATAGTCAAGTCC,MPEEWVRIFGEAGITQFEQQRNPRLCLSVLNILSKSEHPQEKFMFVPYEQSALPVTDNSPFGDTSITHNYADHHFKASTPENEGSSFYSRVPGPCTVGVRSSSLSSGRGSSEGVGSRSGSGSGGAASRSSSSGHGGAGFPLPVTSVPANGRSSAPGPNSMTVTSGSHSSSGSNCSTGSLTGGMELTNTMVATTQRTGPNNVLVNGHSTGNHFHGGVTQRVAASAAPTECNVLPTYTGSSSSYQPTSFQSMAVHTPPAYTLRQIPPAHSIGYPYTSTAPTSESIILTAPTTTPSSTVYHTTQGSAIVKPLSDNQSQRDKLPYLMHKSQWHSNVTGHVPLSPGLPRRFVDGVLPPETSAHIQYSSGQSSPSPAGSATPVPTPRRESLAGSVPVRAGPAPPALATHELSSDANCTLTPPPVATRPEKTKSIYTKPVEAQCDGHLTIGDQQDASRRSLETPVPPQTAATIHGSENETRTNVTVLPTVHSDGNNSSVHAYQQATESRPLKPNTLERQGQKKVRPKISDEAIQEKLRMIVSIGDPNRKYQRQEKIGQGASGTVYGGIEVATGRRVAIKQMNLKQQPKKELIVNEIYVMKAKKHPNVVNYLDSYLVADELWVVMEYLDGGSLTEVVTETYMEEGQIAAVCRECLQALDFLHKNQVIHRDIKSDNILLGLDGSVKLTDFGFCAQLSSEQNKRSTMVGTPYWMAPEVVTRKQYGPKVDIWSLGIMAIEMLDGEPPYLNENPVRALYLIGTNGKPEIKERDKLSSEFQDFLDLCLEVKVERRATAQELLQHIFSRDGHRAMELLQTDNFHSSGVRKKRTPRLAIEKLVDPEVKRNYQNQLVECLPDGTVSDINGHWEKISKALLKPRRTVVMAAGEDELVVTVRGTSFNCPPTSLVEPNTGIIAPLIEPHHRGIGSYALEVVADIIGTLDYCGIAFLTMGSFVPYLYYSFYCVLWLKLFYLALIFALGSGAIAVSMSNTFASPAYRPLRALVFIALGLSGVIPCVHVTITNGFWPSLQHGSLGWLFLMAVLYITGASIYAVRVPERIFPGRFDIWFQSHQIFHVFVVAAALVHYHGIIGLTNYRLAIGDCRPPPGYPFPKHDYDNIELLRPFMTY,positive +CCCAAUUCCGACCUGCGUCUACGUAACCUGCCAUCG,MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICEVEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASSIVYKKEGEQVEFSFPLAFTVEKLTGSGELWWQAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLPQALPQYAGSGNLTLALEAKTGKLHQEVNLVVMRATQLQKNLTCEVWGPTSPKLMLSLKLENKEAKVSKREKAVWVLNPEAGMWQCLLSDSGQVLLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQAERMSQIKRLLSEKKTCQCPHRFQKTCSPI,positive +GGGAGAGGAGGGAGAUAGAUAUCAAACAAGAUCGCGUCUACUGGCACAGAAAGAGCAAUGCGGAACUAUAGCUGAGAGUUUCGUGGAUGCCACAGGAC,VVIRSNNFTDNAKTIIVQLNESIAINCTRPNNNTRKSIHIGPGRAFYTTGDIIGNIRQAHCNLSRTKWENTLKQIAKKLREQFGNKTIVFNH,positive +AGAAUGACCCGAUGAGGUACGCCACGACUGCCCACUUCUU,MNIKAILSLCLFLILQCVRARVFVSRLEAASLLARSRRANSPFSMEETKQGSLERECREETCNFEEAREIFEDDQRTNAFWTLYIRPNPCLSNPCQNGGTCQHTHTVYMCVCPRGWEGRVCSQEVSTGQSCKVNNGRCDHYCEEEEAAAGGRRGAVCSCAPGYHLARNRRSCMAMEAFPCGRVASPKSDILMGNSSEAATDVPTPTSQAANVNSSSIIGDDSEPQASFGHSNHRGRVVGGKECPRGQCPWQVLISRKGAPVCGGTILSPQWILTAAHCTIYETKNLRILAGEHNVDEVEGSEQELGILRIVDHPSFNIKLSYDNDISLIQLSRPIQFTRYALPICLPNQRFVRGVLRSVVAGTVSGWGKLNEFGPAAGILQRLEVPYVDDEQCRAAMGSKVITANMFCAGYETGGQDSCSGDSGGPHATRYGSTWFLTGVVSWGKGCAREGKFGVYTKVLNYLDWIAQTMAETESHALPEPAQH,positive +CCCUGAUGGUAGACGCCGGGGUGCCGGAA,MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPGPHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR,positive +GGTTGGTGTGGTTGG,QELLCAASLISDRWVLTAAHCLLYPPWDKNFTVNDILVRIGKYARSRYERNMEKISTLEKIIIHPGYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDKQIVTSLLQAGHKGRVTGWGNLKEMWTVNMNEVQPSVLQMVNLPLVERPICKASTGIRVTDNMFCAGYKPEEGKRGDACEGDSGGPFVMKNPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIRKMVDRFG,positive +AGATACGCTCGTGTTGCTCGATAGC,MRKIVVAAIAVSLTTVSITASASADPSKDSKAQVSAAEAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKVKPSAASIDAAKKAGVNNGNPLDAVQQ,positive +CTTCTGCCCGCCTCCTTCCGTTTGATCAAGCTGGTTTGGACTTTCGGAGACGAGATAGGCGGACACT,MGVHECPAWLWLLLSLLSLPLGLPVLGAPPRLICDSRVLERYLLEAKEAENITTGCAEHCSLNENITVPDTKVNFYAWKRMEVGQQAVEVWQGLALLSEAVLRGQALLVNSSQPWEPLQLHVDKAVSGLRSLTTLLRALGAQKEAISPPDAASAAPLRTITADTFRKLFRVYSNFLRGKLKLYTGEACRTGDR,positive +CACCTTGCGAAGCATAGTAACACCCAACACGCCCCATGCG,MAIPKELLVLLLGIAILSKVAECAAFGSRRGLVETVFDVTRFGARPNTPADSTRGLMMAWRSACQSPGPAKVVIPPGTYTTGETIFQGPCTSPRPITIEIQGTLLSNTDMSLYTRAAWISIEHVDGIVITGGGTLNGQGKSSWQFADKSGSTPPLPSSLVFQTVRSSSIKNLNFVDAKGVHLKITDSSDISVSNIKITAPGDSPNTDGLHISDTINVNVTDSTIGTGDDCISIGDGNSNVYISNINCGPGHGISIGSLGKRLDETDVKGVTVRNCTFRGTTNGARIKTYMGSPSLQVSGVVYEDIILDNVKNPIVIDQHYHSKNRNEPSRVKLVDIHFRNIRGTTTSKIPVLLNCSEALPCEGVELVDIDLAPVGSIGPLLPATCQNAKTILNGKNNPPAC,positive +GGACCUUUGUACCCCAGAUGAUGCUUUAUCAGGCGGAUGGGUACAAAUGGCAG,MIPPPRRSASSTPKDYRSSRDLQPWRGVSSGDAAETSQQSRHRRDAIADGGGRLKGAAQSSPSSGTRRSGPYAQGRAMPKNENIPKPGKQRLGPRKKKLSTLKKKILLDRLERWRDKQHEGALSTPSATASSEEAKCNNPFPLCPPGELSPPPSPPATICPAVVDKSTSYGQVGGANGERSVWAITIYNLVDQEDVEDDDDHAEIERDLWDMSSAFGVVRSVQVPRGTAVQVSDAEVSAAAAAGEPAAVAAKVAFATNAEAECARDGLNGRIVGGKPLLVRIHRCDGHFCGGVCPGDPDGSGLWRVAIENLIDEEDDLDDEDEYAEISANVSAMMGCYGKLVDVQVRRSSPSKGEVQEDVATRAATTAGATQAVVVTFGSLAEAEACVQGIKGCRVGGKELDAHVVLDSERVLPSNPAFKCDQEHAHSSDVAAAVAGQGDSMMKQEAGTEPSPCVDQDTAAAVASSTEWRVVIRGLIDEDDLQDDDDDYAEVCSDVTALVSSYGAVVGLDIPRGRETGSCCYGAEPGEAVVVFRSLQEAEACARGLSGRKVAGNILDAQVLTQPAPSQQGPLQGGASGTGPPVANRERKPAKECPLPQHQASSHQSCGKVPELDGSGPGMLRGFGNRVEDCCGRPKIACTDSDEPQAIAAAAPPGQSIEGPKTTALAKAGKRIQTKYQEAAALPKPPGVRGGLPNAYVNQPPDKEVNDLVFEMLQLLFKFQERARLSDPSKAKTRRRLVIGLREVLRGVKAKKVRLLIVAPNVDAVGGEGGLDDKVVEIIDKAREAEYPVVFALSKRKIGKALGKTIKVSAVGVYSFDGANEQQKQLKRRMETISSLPSPSPRQSDPPTDDALASPPSSSACGDSQDPAGKGSRV,positive +AGCCAGTCAAGTTAATGGGTGCCATGCAGAAGCA,PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGKISKIGPENPYNTPVFAIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDESFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPXRXKNPEMVIYQYMDDLYVGSDLEIGQHRAKIEELRSHLLSWGFTTPDKKHQKEPPFLWMGYELHPDSWTVQPIELPEKDSWTVNE,positive +TGACACAAAGACAGACAGGCTATCCAAGAACCCTCTTACTCTGTGAGACGACGCACCGGTCGCAGGTTTTGTCTCACAGACGCTAAAAATACAGACATGCACCAATGAACAATGAGTTCGACCGTGTTCTTGAGTTTTATGGCCGATGTGGTAAGTACTTCTACTGTATCTTCGCGTACCTTAGGTTTAACGTTCTCTTTTTCGGAATGTGCTCGCCCGCGGCATCCGACGTCCCTTTGGGGGGTAGGTGCAACGGGAATCTTGAGGGATCATT,MRKIVVAAIAVSLTTVSITASASADPSKDSKAQVSAAEAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKVKPSAASIDAAKKAGVNNGNPLDAVQQ,positive +CAGCUAGAGGCAAAGUGGUCUCGACGUAGGGGGACCUGCUCGCUG,MSSTESPVPAAAAPAEAVPASTPAPAAEQPAVGNGEQRNNADAANNTSLYVGELDPSVTEAMLFEIFSMIGTVASIRVCRDAVTRRSLGYAYVNFLNAADGERAMEQLNYSLIRNRPCRIMWSQRDPALRRTGQGNIFIKNLDAGIDNKALHDTFAAFGNILSCKVATNETGSLGYGFVHYETAEAAEAAIKHVNGMLLNDKKVYVGHHIPRKERQAKIEETRANFTNVYAKNVDPEVTDDEFEKLFTKFGKITSCVLQRDEDGKSKGFGFVNFEDHNEAQKAVDELHDSDFKGQKLFVARAQKKSEREEELRRSYEAAKNEKLAKFQGVNLYLKNIPESYDDERLREEFAPFGAITSCKIMRAPSGVSRGFGFVCYSAPEEANKAVSEMNGKMLDNRPLYVALAQRKDVRRQQLEAQIMQRNQLRLQQQAAAQGMGYPGPGMYYPQPGAFPGQPGGMVPRPRYAPAGMMPQGMPMAPYGQPGQFPAGMMPQGYRPARPPRGAPNAAGGPAPPAGARPPTGVNGAPRPAGQPVPGQPMPRGPAARPAGRPEADQPGALTAAALAKASPEEQKQMLGEAIYPKVAASQPELAGKLTGMILELPVTELLHLLEESEALDAKVNEALEVLKEYQQNDSAGAEAEANAEAPKTEA,positive +AAGACGGCCCCCGCCAAUCAAGGGAGAUCCGAGGAAUUGG,MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC,positive +GGGAGAGGAGAGAACGUUCUACCUUGCCUAACAGGAGGUGGAGUAUUGGACCCGCUGUCGAUCGAUCGAUCGAUG,ASFTCLAIWALASAGVVPLVLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAAFFFVPVIISTVCYVSIIRCLSSSAVANRSKK,positive +GGGAGAAGGGAAGTAACAGGUGGGCGCGUGAUUAUGUUUGUACGAAGACUGTGAGAAGAGGTGACGGTACCAG,QELLCAASLISDRWVLTAAHCLLYPPWDKNFTVNDILVRIGKYARSRYERNMEKISTLEKIIIHPGYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDKQIVTSLLQAGHKGRVTGWGNLKEMWTVNMNEVQPSVLQMVNLPLVERPICKASTGIRVTDNMFCAGYKPEEGKRGDACEGDSGGPFVMKNPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIRKMVDRFG,positive +AATACGACTCACTATAGAGGGAGGACGATGCGGGGTGCTTCGAGCGTAGGAAGAAAGCCGGGGGCTGCAGATAATGTATAGCCAGACGACGGA,MTRCTADNSLTNPAYRRRTMATGEMKEFLGIKGTEPTDFGINSDAQDLPSPSRQASTRRMSIGESIDGKINDWEEPRLDIEGFVVDYFTHRIRQNGMEWFGAPGLPCGVQPEHEMMRVMGTIFEKKHAENFETFCEQLLAVPRISFSLYQDVVRTVGNAQTDQCPMSYGRLIGLISFGGFVAAKMMESVELQGQVRNLFVYTSLFIKTRIRNNWKEHNRSWDDFMTLGKQMKEDYERAEAEKVGRRKQNRRWSMIGAGVTAGAIGIVGVVVCGRMMFSLK,positive +TGACTGCCGCACCGACCATTCACGGTATTGGCACGGCC,MPSNQEARLFLAVLVLAQVLPILVDSAAEKGFKQAFWQPLCQVSEELDDQPKGALFTLQAAASKIQKMRDAALRASIYAEINHGTNRAKAAVIVANHYAMKADSGLEALKQTLSSQEVTATATASYLKGRIDEYLNLLLQTKESGTSGCMMDTSGTNTVTKAGGTIGGVPCKLQLSPIQPKRPAATYLGKAGYVGLTRQADAANNFHDNDAECRLASGHNTNGLGKSGQLSAAVTMAAGYVTVANSQTAVTVQALDALQEASGAAHQPWIDAWKAKKALTGAETAEFRNETAGIAGKTGVTKLVEEALLKKKDSEASEIQTELKKYFSGHENEQWTAIEKLISEQPVAQNLVGDNQPTKLGELEGNAKLTTILAYYRMETAGKFEVLTQKHKPAESQQQAAETEGSCNKKDQNECKSPCKWHNDAENKKCTLDKEEAKKVADETAKDGKTGNTNTTGSSNSFVISKTPLWLAVLLF,positive +GAAUCAAUACACAGUCCUGGGUGCUAACCAUGAACACCCAAGGCCUUAGUGGUAUGUGGUUAUUG,MAGRSGDSDEELLKAVRLIKFLYQSNPPPNPEGTRQARRNRRRRWRERQRQIHSISERILSTYLGRSAEPVPLQLPPLERLTLDCNEDCGTSGTQGVGSPQILVESPTILESGAKE,positive +AGGAGAAUUAUGAGCGGGACAACUUCGUUCCGUGUUCGCGUACUGAGCGC,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,positive +UUAACCAUCAGCUCAUGGCCCCUGCCCUCUCAAGGACCAC,MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYTFLLPEMDNCRSSSSPYVSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQDNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVLVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF,positive +GGGACACAATGGACGUCCGCGGCGCCAUCUCAUGUUUAGUUGUCCUAUGUCGAGCUAACGGCCGACAUGAGAG,PHITDVVLDKANKTPLRQLDPSRLPDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFAKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRQSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPINRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDTASEATRPATLNRFSALQQTLPAENTDNRRVVQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRTRTPATKRSFSKEVEERSRERPSQPEGLRKAASLTEDRGRDPVKREATLPPVSPPKAALSVDEVEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRLGIESTLERSTIAREHMGRLLHQLLCAGHLSTAQYYQGLYETLELAEDMEIDIPHVWLYLAELITPILQEDGVPMGELFREITKPLRPMGKATSLLLEILGLLCKSMGPKKVGMLWREAGLSWREFLAEGQDVGSFVAEKKVEYTLGEESEAPGQRTLAFEELRRQLEKLLKDGGSNQRVFDWIDANLNEQQIASNTLVRALMTTVCYSAIIFETPLRVDVQVLKVRARLLQKYLCDEQKELQALYALQALVVTLEQPANLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFNWLREAEDEESDHN,positive +CCAGAAGAAGCCCACTAGCGTGCTTTTGTC,MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA,positive +AUUACCGGCGAGUUUUGAACCGCGUAAU,MASDSIFESFPSYPQCFMRECILGMNPSRDVHDASTSRRFTPPSTALSPGKMSEALPLGAPDAGAALAGKLRSGDRSMVEVLADHPGELARTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFNPQPQSQMQDTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLSTAPSFLFLSNKMLTCKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK,positive +GGCGAAUUCAGGGGACGUAGCAAUGACUGCC,MKPGGNTIVIWMYAVATWLCFGSTSGWSFTLEDNNIFPKQYPIINFTTAGATVQSYTNFIRAVRGRLTTGADVRHEIPVLPNRVGLPINQRFILVELSNHAELSVTLALDVTNAYVVGYRAGNSAYFFHPDNQEDAEAITHLFTDVQNRYTFAFGGNYDRLEQLAGNLRENIELGNGPLEEAISALYYYSTGGTQLPTLARSFIICIQMISEAARFQYIEGEMRTRIRYNRRSAPDPSVITLENSWGRLSTAIQESNQGAFASPIQLQRRNGSKFSVYDVSILIPIIALMVYRCAPPPSSQFSLLIRPVVPNFNADVCMDPEPIVRIVGRNGLCVDVRDGRFHNGNAIQLWPCKSNTDANQLWTLKRDNTIRSNGKCLTTYGYSPGVYVMIYDCNTAATDATRWQIWDNGTIINPRSSLVLAATSGNSGTTLTVQTNIYAVSQGWLPTNNTQPFVTTIVGLYGLCLQANSGQVWIEDCSSEKAEQQWALYADGSIRPQQNRDNCLTSDSNIRETVVKILSCGPASSGQRWMFKNDGTILNLYSGLVLDVRASDPSLKQIILYPLHGDPNQIWLPLF,positive +GTTTCCAAAGCCGGGGGGGTGGGATGGGTT,MQLPLALCLVCLLVHTAFRVVEGQGWQAFKNDATEIIPELGEYPEPPPELENNKTMNRAENGGRPPHHPFETKDVSEYSCRELHFTRYVTDGPCRSAKPVTELVCSGQCGPARLLPNAIGRGKWWRPSGPDFRCIPDRYRAQRVQLLCPGGEAPRARKVRLVASCKCKRLTRFHNQSELKDFGTEAARPQKGRKPRPRARSAKANQAELENAY,positive +ATATTAAAAATTATT,MSARGEEAAGEASGSQEQPEPALAEPKKRGPGRPRKPQQEPTGEPVPKRPRGRPKGSKNKGPSKAAQKKAETTGEKRPRGRPRKWPQQVVQEKPAQEEEEEEEEEEAEED,positive +GACAUCUGUAAGUAAGAUUCUAUCUGCAAAGCGGUUAGGAGGGCUCGGACUCUGAUUGCCUCCCCGCACC,MSGGDGRGHNTGAHSTSGNINGGPTGLGVGGGASDGSGWSSENNPWGGGSGSGIHWGGGSGHGNGGGNGNSGGGSGTGGNLSAVAAPVAFGFPALSTPGAGGLAVSISAGALSAAIADIMAALKGPFKFGLWGVALYGVLPSQIAKDDPNMMSKIVTSLPADDITESPVSSLPLDKATVNVNVRVVDDVKDERQNISVVSGVPMSVPVVDAKPTERPGVFTASIPGAPVLNISVNNSTPAVQTLSPGVTNNTDKDVRPAGFTQGGNTRDAVIRFPKDSGHNAVYVSVSDVLSPDQVKQRQDEENRRQQEWDATHPVEAAERNYERARAELNQANEDVARNQERQAKAVQVYNSRKSELDAANKTLADAIAEIKQFNRFAHDPMAGGHRMWQMAGLKAQRAQTDVNNKQAAFDAAAKEKSDADAALSSAMESRKKKEDKKRSAENNLNDEKNKPRKGFKDYGHDYHPAPKTENIKGLGDLKPGIPKTPKQNGGGKRKRWTGDKGRKIYEWDSQHGELEGYRASDGQHLGSFDPKTGNQLKGPDPKRNIKKYL,positive +AGAACAAAGTCAGGACGTTCCGAACTAATGATCCAATCAG,MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQRGLKNVFDEAILAALEPPETQPKRKCCIF,positive +CAGCGGCCCAGACCAGGAGGGGUGAUGGUGGGCAAGUGGGUCGCUG,MSSTESPVPAAAAPAEAVPASTPAPAAEQPAVGNGEQRNNADAANNTSLYVGELDPSVTEAMLFEIFSMIGTVASIRVCRDAVTRRSLGYAYVNFLNAADGERAMEQLNYSLIRNRPCRIMWSQRDPALRRTGQGNIFIKNLDAGIDNKALHDTFAAFGNILSCKVATNETGSLGYGFVHYETAEAAEAAIKHVNGMLLNDKKVYVGHHIPRKERQAKIEETRANFTNVYAKNVDPEVTDDEFEKLFTKFGKITSCVLQRDEDGKSKGFGFVNFEDHNEAQKAVDELHDSDFKGQKLFVARAQKKSEREEELRRSYEAAKNEKLAKFQGVNLYLKNIPESYDDERLREEFAPFGAITSCKIMRAPSGVSRGFGFVCYSAPEEANKAVSEMNGKMLDNRPLYVALAQRKDVRRQQLEAQIMQRNQLRLQQQAAAQGMGYPGPGMYYPQPGAFPGQPGGMVPRPRYAPAGMMPQGMPMAPYGQPGQFPAGMMPQGYRPARPPRGAPNAAGGPAPPAGARPPTGVNGAPRPAGQPVPGQPMPRGPAARPAGRPEADQPGALTAAALAKASPEEQKQMLGEAIYPKVAASQPELAGKLTGMILELPVTELLHLLEESEALDAKVNEALEVLKEYQQNDSAGAEAEANAEAPKTEA,positive +TCAGACACTTTGCCAAAAAACATGATACAAGTTCGCTGCC,MKKRKVLIPLMALSTILVSSTGNLEVIQAEVKQENRLLNESESSSQGLLGYYFSDLNFQAPMVVTSSTTGDLSIPSSELENIPSENQYFQSAIWSGFIKVKKSDEYTFATSADNHVTMWVDDQEVINKASNSNKIRLEKGRLYQIKIQYQRENPTEKGLDFKLYWTDSQNKKEVISSDNLQLPELKQKSSNSRKKRSTSAGPTVPDRDNDGIPDSLEVEGYTVDVKNKRTFLSPWISNIHEKKGLTKYKSSPEKWSTASDPYSDFEKVTGRIDKNVSPEARHPLVAAYPIVHVDMENIILSKNEDQSTQNTDSQTRTISKNTSTSRTHTSEVHGNAEVHASFFDIGGSVSAGFSNSNSSTVAIDHSLSLAGERTWAETMGLNTADTARLNANIRYVNTGTAPIYNVLPTTSLVLGKNQTLATIKAKENQLSQILAPNNYYPSKNLAPIALNAQDDFSSTPITMNYNQFLELEKTKQLRLDTDQVYGNIATYNFENGRVRVDTGSNWSEVLPQIQETTARIIFNGKDLNLVERRIAAVNPSDPLETTKPDMTLKEALKIAFGFNEPNGNLQYQGKDITEFDFNFDQQTSQNIKNQLAELNATNIYTVLDKIKLNAKMNILIRDKRFHYDRNNIAVGADESVVKEAHREVINSSTEGLLLNIDKDIRKILSGYIVEIEDTEGLKEVINDRYDMLNISSLRQDGKTFIDFKKYNDKLPLYISNPNYKVNVYAVTKENTIINPSENGDTSTNGIKKILIFSKKGYEIG,positive +ATACCAGCTTATTCAATTGACATGACTGGGATTTTTGGCGAAATCGAAGGAAGCGGAGAGATAGTAAGTGCAATCT,MPFVNKQFNYKDPVNGVDIAYIKIPNAGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAGHRLYGIAINPNRVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNRKTYLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLKNFTGLFEFYKLLCVRGIITSKTKSLDKGYNKALNDLCIKVNNWDLFFSPSEDNFTNDLNKGEEITSDTNIEAAEENISLDLIQQYYLTFNFDNEPENISIENLSSDIIGQLELMPNIERFPNGKKYELDKYTMFHYLRAQEFEHGKSRIALTNSVNEALLNPSRVYTFFSSDYVKKVNKATEAAMFLGWVEQLVYDFTDETSEVSTTDKIADITIIIPYIGPALNIGNMLYKDDFVGALIFSGAVILLEFIPEIAIPVLGTFALVSYIANKVLTVQTIDNALSKRNEKWDEVYKYIVTNWLAKVNTQIDLIRKKMKEALENQAEATKAIINYQYNQYTEEEKNNINFNIDDLSSKLNESINKAMININKFLNQCSVSYLMNSMIPYGVKRLEDFDASLKDALLKYIYDNRGTLIGQVDRLKDKVNNTLSTDIPFQLSKYVDNQRLLSTFTEYIKNIINTSILNLRYESNHLIDLSRYASKINIGSKVNFDPIDKNQIQLFNLESSKIEVILKNAIVYNSMYENFSTSFWIRIPKYFNSISLNNEYTIINCMENNSGWKVSLNYGEIIWTLQDTQEIKQRVVFKYSQMINISDYINRWIFVTITNNRLNNSKIYINGRLIDQKPISNLGNIHASNNIMFKLDGCRDTHRYIWIKYFNLFDKELNEKEIKDLYDNQSNSGILKDFWGDYLQYDKPYYMLNLYDPNKYVDVNNVGIRGYMYLKGPRGSVMTTNIYLNSSLYRGTKFIIKKYASGNKDNIVRNNDRVYINVVVKNKEYRLATNASQAGVEKILSALEIPDVGNLSQVVVMKSKNDQGITNKCKMNLQDNNGNDIGFIGFHQFNNIAKLVASNWYNRQIERSSRTLGCSWEFIPVDDGWGERPL,positive +AAAAAAAAAAAAAAA,MSARGEEAAGEASGSQEQPEPALAEPKKRGPGRPRKPQQEPTGEPVPKRPRGRPKGSKNKGPSKAAQKKAETTGEKRPRGRPRKWPQQVVQEKPAQEEEEEEEEEEAEED,positive +CTTCTGCCCGCCTCCTTCCTTCTTGAATTTTGAGATGAGGTCACTAGGTCCTTCGCGGGGAGACGAGATAGGCGGACACT,MEGMLKGEGPGPLPPLLQQYVELRDQYPDYLLLFQVGDFYECFGEDAERLARALGLVLTHKTSKDFTTPMAGIPLRAFEAYAERLLKMGFRLAVADQVEPAEEAEGLVRREVTQLLTPGTLLQESLLPREANYLAAIATGDGWGLAFLDVSTGEFKGTVLKSKSALYDELFRHRPAEVLLAPELLENGAFLDEFRKRFPVMLSEAPFEPEGEGPLALRRARGALLAYAQRTQGGALSLQPFRFYDPGAFMRLPEATLRALEVFEPLRGQDTLFSVLDETRTAPGRRLLQSWLRHPLLDRGPLEARLDRVEGFVREGALREGVRRLLYRLADLERLATRLELGRASPKDLGALRRSLQILPELRALLGEEVGLPDLSPLKEELEAALVEDPPLKVSEGGLIREGYDPDLDALRAAHREGVAYFLELEERERERTGIPTLKVGYNAVFGYYLEVTRPYYERVPKEYRPVQTLKDRQRYTLPEMKEKEREVYRLEALIRRREEEVFLEVRERAKRQAEALREAARILAELDVYAALAEVAVRYGYVRPRFGDRLQIRAGRHPVVERRTEFVPNDLEMAHELVLITGPNMAGKSTFLRQTALIALLAQVGSFVPAEEAHLPLFDGIYTRIGASDDLAGGKSTFMVEMEEVALILKEATENSLVLLDEVGRGTSSLDGVAIATAVAEALHERRAYTLFATHYFELTALGLPRLKNLHVAAREEAGGLVFYHQVLPGPASKSYGVEVAAMAGLPKEVVARARALLQAMAARREGALDAVLERLLALDPDRLTPLEALRLLQELKALALGAPLDTMKG,positive +GAGCCAGUAAGUGACCCGUACUAAUACUGUUGAGUAGUAUGUAGAGGAGUGGUGAUCCUCCAAACUGCUG,MAGRSGDSDEELLKAVRLIKFLYQSNPPPNPEGTRQARRNRRRRWRERQRQIHSISERILSTYLGRSAEPVPLQLPPLERLTLDCNEDCGTSGTQGVGSPQILVESPTILESGAKE,positive +TCCCTTCATCATTAACCCGTCCACGCGC,MHGDTPTLHEYMLDLQPETTDLYCYEQLNDSSEEEDEIDGPAGQAEPDRAHYNIVTFCCKCDSTLRLCVQSTHVDIRTLEDLLMGTLGIVCPICSQKP,positive +UGACGCGAUCCGCCGUUCCCAUCCGCACGCCCUACACCU,MGVLLTQRTLLSLVLALLFPSMASMAAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQGLDVPKLREHCRERPGAFPSEETLRGLGRRGFLQTLNATLGCVLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILGLRNNIYCMAQLLDNSDTAEPTKAGRGASQPPTPTPASDAFQRKLEGCRFLHGYHRFMHSVGRVFSKWGESPNRSRRHSPHQALRKGVRRTRPSRKGKRLMTRGQLPR,positive +GGACCUUUGUACCCCAGAUGAUAGUGAGGCGCGGCUUGAUGGGUACAAAUGGCAG,MIPPPRRSASSTPKDYRSSRDLQPWRGVSSGDAAETSQQSRHRRDAIADGGGRLKGAAQSSPSSGTRRSGPYAQGRAMPKNENIPKPGKQRLGPRKKKLSTLKKKILLDRLERWRDKQHEGALSTPSATASSEEAKCNNPFPLCPPGELSPPPSPPATICPAVVDKSTSYGQVGGANGERSVWAITIYNLVDQEDVEDDDDHAEIERDLWDMSSAFGVVRSVQVPRGTAVQVSDAEVSAAAAAGEPAAVAAKVAFATNAEAECARDGLNGRIVGGKPLLVRIHRCDGHFCGGVCPGDPDGSGLWRVAIENLIDEEDDLDDEDEYAEISANVSAMMGCYGKLVDVQVRRSSPSKGEVQEDVATRAATTAGATQAVVVTFGSLAEAEACVQGIKGCRVGGKELDAHVVLDSERVLPSNPAFKCDQEHAHSSDVAAAVAGQGDSMMKQEAGTEPSPCVDQDTAAAVASSTEWRVVIRGLIDEDDLQDDDDDYAEVCSDVTALVSSYGAVVGLDIPRGRETGSCCYGAEPGEAVVVFRSLQEAEACARGLSGRKVAGNILDAQVLTQPAPSQQGPLQGGASGTGPPVANRERKPAKECPLPQHQASSHQSCGKVPELDGSGPGMLRGFGNRVEDCCGRPKIACTDSDEPQAIAAAAPPGQSIEGPKTTALAKAGKRIQTKYQEAAALPKPPGVRGGLPNAYVNQPPDKEVNDLVFEMLQLLFKFQERARLSDPSKAKTRRRLVIGLREVLRGVKAKKVRLLIVAPNVDAVGGEGGLDDKVVEIIDKAREAEYPVVFALSKRKIGKALGKTIKVSAVGVYSFDGANEQQKQLKRRMETISSLPSPSPRQSDPPTDDALASPPSSSACGDSQDPAGKGSRV,positive +CAAGGCAGAAUGUAAUGCUGAAUAAGAGAGAAAAGUGUUGGUGAG,MSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEMLDRHHTHFCPLEGESWQDFLRNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAFLCQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERETPTTDSMPPLLRQAIELFDHQGAEPAFLFGLELIICGLEKQLKCESGS,positive +AUCGCCCUGAACCGGCCCAGCAGACUGCUGACGGAACGAC,MGVLLTQRTLLSLVLALLFPSMASMAAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQGLDVPKLREHCRERPGAFPSEETLRGLGRRGFLQTLNATLGCVLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILGLRNNIYCMAQLLDNSDTAEPTKAGRGASQPPTPTPASDAFQRKLEGCRFLHGYHRFMHSVGRVFSKWGESPNRSRRHSPHQALRKGVRRTRPSRKGKRLMTRGQLPR,positive +CGGAATTCCGAGCGTGGGCGTGAGCCCTAAACACAAGTCCGCAGGGGTGTGGTAATATTCGCAGTTGTGTGTACGCCCACGCTCGAG,DHNPPTIELIQRFCSDVDMWLKEDSSNVVAVHCKAGKGRTGTMICAYLVFSGIKKSADEALAWYDEKRTKDRKGVTIPSQRRYVQYFSKLVCSSVPYSKVSLNVCEIRFSESSCVQNLGMVECSISVLHDSATENAKPDRLKTLPIDFQKSFVLTIKPSIPVSGDVKFELTKKSPDKIICHFWLNTFFVRNYSPCESDGTVNKYIHTLSKSEIDDVHKDSEHKRFSEEFKISIVFEAENFSNDVQAEASEKERNENVLNFERSDYDSLSPNCYAEKKVLTAIVNDNTTKSQTIETLDHKDIVTKIQYDTSTNSKNTSTACKRKQPNSKTLLPSLNDSTKEEIKRNHIFNQPSIKKTDLIKWQNSEVHITRSINENKNINYNSYITCKQSSPKFNCGTEDGEEDWESGESTYL,positive +GGGAAUAAUAAUAAUAAUG,GRQVDIDGEDYQRRDSIAQLLEDWGLIVIEDSAREDLFGLTNNFRVISFKQKDDWTLKAKYTIGN,positive +GGGAGCTCAGAATAAACGCTCAAGAAGGTGGGAGGGTGGGGTGGTTGAAGAATGTTCGACATGAGGCCCGGATC,MLNQLDNLTERVRGSNKLVDRWLHVRKHLLVAYYNLVGIKPGKESYMRLNEKALDDFCQSLVDYLSAGHFSIYERILHKLEGNGQLARAAKIWPQLEANTQQIMDYYDSSLETAIDHDNYLEFQQVLSDIGEALEARFVLEDKLILLVLDAARVKHPA,positive +CTCCTCTGACTGTAACCACGGTATAAACCTAGTACGAAGCGTATCTTTACGGGTGCCTGAGCATAGGTAGTCCAGAAGCC,MLDLFADAEPWQEPLAAGAVILRRFAFNAAEQLIRDINDVASQSPFRQMVTPGGYTMSVAMTNCGHLGWTTHRQGYLYSPIDPQTNKPWPAMPQSFHNLCQRAATAAGYPDFQPDACLINRYAPGAKLSLHQDKDEPDLRAPIVSVSLGLPAIFQFGGLKRNDPLKRLLLEHGDVVVWGGESRLFYHGIQPLKAGFHPLTIDCRYNLTFRQAGKKE,positive +GGGCCGTTCGAACCGAGCATGGATCGAGGATGGGAACACCCAGTAGGAGGATGGGCATGGCCGGACCCAAAATTAGCAGTGGGACAGTACTCAGGTCATCCTAGG,GSNITRVESETKVVILDSFEPLRAETDDAELSVAAECLKKPPKYPPALPIWARPDYNPPLLDRWKAPDYVPPTVHGCALPPQA,positive +GGGACACAAUGGACGAAGCCAGUCGCAUUGGCCGAGCUGUCGCUCUGACCAACUGGUAACGGCCGACAUGAGAG,PHITDVVLDKANKTPLRQLDPSRLPDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFAKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRQSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPINRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDTASEATRPATLNRFSALQQTLPAENTDNRRVVQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRTRTPATKRSFSKEVEERSRERPSQPEGLRKAASLTEDRGRDPVKREATLPPVSPPKAALSVDEVEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRLGIESTLERSTIAREHMGRLLHQLLCAGHLSTAQYYQGLYETLELAEDMEIDIPHVWLYLAELITPILQEDGVPMGELFREITKPLRPMGKATSLLLEILGLLCKSMGPKKVGMLWREAGLSWREFLAEGQDVGSFVAEKKVEYTLGEESEAPGQRTLAFEELRRQLEKLLKDGGSNQRVFDWIDANLNEQQIASNTLVRALMTTVCYSAIIFETPLRVDVQVLKVRARLLQKYLCDEQKELQALYALQALVVTLEQPANLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFNWLREAEDEESDHN,positive +TATTAGTAATAATATTAGTAATAA,MDHLNEATQGKEHSEMSNNVSDPKGPPAKIARLEQNGSPLGRGRLGSTGAKMQGVPLKHSGHLMKTNLRKGTMLPVFCVVEHYENAIEYDCKEEHAEFVLVRKDMLFNQLIEMALLSLGYSHSSAAQAKGLIQVGKWNPVPLSYVTDAPDATVADMLQDVYHVVTLKIQLHSCPKLEDLPPEQWSHTTVRNALKDLLKDMNQSSLAKECPLSQSMISSIVNSTYYANVSAAKCQEFGRWYKHFKKTKDMMVEMDSLSELSQQGANHVNFGQQPVPGNTAEQPPSPAQLSHGSQPSVRTPLPNLHPGLVSTPISPQLVNQQLVMAQLLNQQYAVNRLLAQQSLNQQYLNHPPPVSRSMNKPLEQQVSTNTEVSSEIYQWVRDELKRAGISQAVFARVAFNRTQGLLSEILRKEEDPKTASQSLLVNLRAMQNFLQLPEAERDRIYQDERERSLNAASAMGPAPLISTPPSRPPQVKTATIATERNGKPENNTMNINASIYDEIQQEMKRAKVSQALFAKVAATKSQGWLCELLRWKEDPSPENRTLWENLSMIRRFLSLPQPERDAIYEQESNAVHHHGDRPPHIIHVPAEQIQQQQQQQQQQQQQQQAPPPPQPQQQPQTGPRLPPRQPTVASPAESDEENRQKTRPRTKISVEALGILQSFIQDVGLYPDEEAIQTLSAQLDLPKYTIIKFFQNQRYYLKHHGKLKDNSGLEVDVAEYKEEELLKDLEESVQDKNTNTLFSVKLEEELSVEGNTDINTDLKD,positive +CCTTCGTTGTCTGCCTTCGTAGCGGATCGAATTACGCGTTAACGGCAACCGATAACGGGACCGATTGCACACCCTTCAGAATTCGCACCA,MKQYLNTVISNPRPAQALGINQPFVVFCFITSRALSFVPAIYWCFKCLHLAFVADKFKWLPLTSALWTLVSAYLSFVLANGFLLKWLIHYSIGPTIIRLFSLNVINFSFLSLSVSFITHGDNAYLLPAWIAISCFQTAAYIVQDWITSPIIRTLPFRSSSSSSSNYRHNLDFLEITVFAVVPVGIASFFTMVMLIWQLYKYPDSFLVSA,positive +UUGUUACACACCCGAUUGAAAAAGCGAGUCUGACAG,MSAPASTTQATGSTTSTTTKTAGATPATASGLFTIPDGDFFSTARAVVASDAVATNEDLSEIEAVWKDMKVPTDTMAQAAWDLVRHCADVGSSAQTEMIDTGPYSNGISRARLAAAIKEVCTLRQFCMKYAPVVWNWMLTNNSPPANWQAQGFKPEHKFAAFDFFNGVTNPAAIMPKEGLIRPPSEAEMNAAQTAAFVKITKARAQSNDFASLDAAVTRGRITGTTTAEAVVTLPPP,positive +GGGUUACCUAGGUGUAGAUGCUCUUCAGAUUCAUUUAUAAGAUCCGACAACCUGUCUAUUAGUUGCGCCGAUUAAGUGACGUCUGAACUGCUUCGAA,PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGKISKIGPENPYNTPVFAIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDESFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPXRXKNPEMVIYQYMDDLYVGSDLEIGQHRAKIEELRSHLLSWGFTTPDKKHQKEPPFLWMGYELHPDSWTVQPIELPEKDSWTVNE,positive +CGTTCGAAATTCGAACCTGTGTG,GLVKKAHEISVLCDAELALIIFSPKGKLYEYATDSKMEIILERYERYTYAEKALIASDPDVQGNWCHEYIKLKAKFEALNKSQRHLMGEQLDTLNQKELLQLETKLEGSLKNVRSRKTQLMLDSISELQEKGKSLQEQNTCLEKEILGKQKDKAPKQHVQWEKQNQPPPTSSAPMPFLIGDIHPTPNIRNFQGRTVADA,positive +ATACCAGCTTATTCAATTCCTAATCTTCATGCGTTAATATTTACTGTGCGTTGCTTCGAGATAGTAAGTGCAATCT,MPFVNKQFNYKDPVNGVDIAYIKIPNAGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAGHRLYGIAINPNRVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNRKTYLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLKNFTGLFEFYKLLCVRGIITSKTKSLDKGYNKALNDLCIKVNNWDLFFSPSEDNFTNDLNKGEEITSDTNIEAAEENISLDLIQQYYLTFNFDNEPENISIENLSSDIIGQLELMPNIERFPNGKKYELDKYTMFHYLRAQEFEHGKSRIALTNSVNEALLNPSRVYTFFSSDYVKKVNKATEAAMFLGWVEQLVYDFTDETSEVSTTDKIADITIIIPYIGPALNIGNMLYKDDFVGALIFSGAVILLEFIPEIAIPVLGTFALVSYIANKVLTVQTIDNALSKRNEKWDEVYKYIVTNWLAKVNTQIDLIRKKMKEALENQAEATKAIINYQYNQYTEEEKNNINFNIDDLSSKLNESINKAMININKFLNQCSVSYLMNSMIPYGVKRLEDFDASLKDALLKYIYDNRGTLIGQVDRLKDKVNNTLSTDIPFQLSKYVDNQRLLSTFTEYIKNIINTSILNLRYESNHLIDLSRYASKINIGSKVNFDPIDKNQIQLFNLESSKIEVILKNAIVYNSMYENFSTSFWIRIPKYFNSISLNNEYTIINCMENNSGWKVSLNYGEIIWTLQDTQEIKQRVVFKYSQMINISDYINRWIFVTITNNRLNNSKIYINGRLIDQKPISNLGNIHASNNIMFKLDGCRDTHRYIWIKYFNLFDKELNEKEIKDLYDNQSNSGILKDFWGDYLQYDKPYYMLNLYDPNKYVDVNNVGIRGYMYLKGPRGSVMTTNIYLNSSLYRGTKFIIKKYASGNKDNIVRNNDRVYINVVVKNKEYRLATNASQAGVEKILSALEIPDVGNLSQVVVMKSKNDQGITNKCKMNLQDNNGNDIGFIGFHQFNNIAKLVASNWYNRQIERSSRTLGCSWEFIPVDDGWGERPL,positive +GGACCUUUGUACCCCAGAUGACGGCUCAUUUCGUGCUUGAUGGGUACAAAUGGCAG,MIPPPRRSASSTPKDYRSSRDLQPWRGVSSGDAAETSQQSRHRRDAIADGGGRLKGAAQSSPSSGTRRSGPYAQGRAMPKNENIPKPGKQRLGPRKKKLSTLKKKILLDRLERWRDKQHEGALSTPSATASSEEAKCNNPFPLCPPGELSPPPSPPATICPAVVDKSTSYGQVGGANGERSVWAITIYNLVDQEDVEDDDDHAEIERDLWDMSSAFGVVRSVQVPRGTAVQVSDAEVSAAAAAGEPAAVAAKVAFATNAEAECARDGLNGRIVGGKPLLVRIHRCDGHFCGGVCPGDPDGSGLWRVAIENLIDEEDDLDDEDEYAEISANVSAMMGCYGKLVDVQVRRSSPSKGEVQEDVATRAATTAGATQAVVVTFGSLAEAEACVQGIKGCRVGGKELDAHVVLDSERVLPSNPAFKCDQEHAHSSDVAAAVAGQGDSMMKQEAGTEPSPCVDQDTAAAVASSTEWRVVIRGLIDEDDLQDDDDDYAEVCSDVTALVSSYGAVVGLDIPRGRETGSCCYGAEPGEAVVVFRSLQEAEACARGLSGRKVAGNILDAQVLTQPAPSQQGPLQGGASGTGPPVANRERKPAKECPLPQHQASSHQSCGKVPELDGSGPGMLRGFGNRVEDCCGRPKIACTDSDEPQAIAAAAPPGQSIEGPKTTALAKAGKRIQTKYQEAAALPKPPGVRGGLPNAYVNQPPDKEVNDLVFEMLQLLFKFQERARLSDPSKAKTRRRLVIGLREVLRGVKAKKVRLLIVAPNVDAVGGEGGLDDKVVEIIDKAREAEYPVVFALSKRKIGKALGKTIKVSAVGVYSFDGANEQQKQLKRRMETISSLPSPSPRQSDPPTDDALASPPSSSACGDSQDPAGKGSRV,positive +CAAAACGTGGATTGGGTCAAATGAGTCGTTTTTC,MHGDTPTLHEYMLDLQPETTDLYCYEQLNDSSEEEDEIDGPAGQAEPDRAHYNIVTFCCKCDSTLRLCVQSTHVDIRTLEDLLMGTLGIVCPICSQKP,positive +AGCAGCACAGAGGTCAGATGAAGCGATTGTAATCAACGCCGTAAGACCTCGAGTCGATTTCCTATGCGTGCTACCGTGAA,MLSWGYFLFLLPTLPGAQSQVQLVESGGDVRKPGDSLRLSCKGSGFTFSNYWLGWVRQAPGKALNGSLPLTPLAAAPTYIPGVSGRFTISRDNARALLHLDMSDLRPEDTGRYHCER,positive +GAAGCUUACAAGAAGGACAGCACGAAUAAAACCUGCGUAAAUCCGCCCCAUUUGUGUAAAAAAAAAAAAAAAAAAAAAAAAA,MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINYDEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQAVAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQGIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADMDFSALLSQISS,positive +AGCAAGGGCCACUGCAAAGCACGCGAGCAU,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,positive +GGACCUUUGUACCCCAGAUGAUAGUAAAGCGCGGCUUGAUGGGUACAAAUGGCAG,MIPPPRRSASSTPKDYRSSRDLQPWRGVSSGDAAETSQQSRHRRDAIADGGGRLKGAAQSSPSSGTRRSGPYAQGRAMPKNENIPKPGKQRLGPRKKKLSTLKKKILLDRLERWRDKQHEGALSTPSATASSEEAKCNNPFPLCPPGELSPPPSPPATICPAVVDKSTSYGQVGGANGERSVWAITIYNLVDQEDVEDDDDHAEIERDLWDMSSAFGVVRSVQVPRGTAVQVSDAEVSAAAAAGEPAAVAAKVAFATNAEAECARDGLNGRIVGGKPLLVRIHRCDGHFCGGVCPGDPDGSGLWRVAIENLIDEEDDLDDEDEYAEISANVSAMMGCYGKLVDVQVRRSSPSKGEVQEDVATRAATTAGATQAVVVTFGSLAEAEACVQGIKGCRVGGKELDAHVVLDSERVLPSNPAFKCDQEHAHSSDVAAAVAGQGDSMMKQEAGTEPSPCVDQDTAAAVASSTEWRVVIRGLIDEDDLQDDDDDYAEVCSDVTALVSSYGAVVGLDIPRGRETGSCCYGAEPGEAVVVFRSLQEAEACARGLSGRKVAGNILDAQVLTQPAPSQQGPLQGGASGTGPPVANRERKPAKECPLPQHQASSHQSCGKVPELDGSGPGMLRGFGNRVEDCCGRPKIACTDSDEPQAIAAAAPPGQSIEGPKTTALAKAGKRIQTKYQEAAALPKPPGVRGGLPNAYVNQPPDKEVNDLVFEMLQLLFKFQERARLSDPSKAKTRRRLVIGLREVLRGVKAKKVRLLIVAPNVDAVGGEGGLDDKVVEIIDKAREAEYPVVFALSKRKIGKALGKTIKVSAVGVYSFDGANEQQKQLKRRMETISSLPSPSPRQSDPPTDDALASPPSSSACGDSQDPAGKGSRV,positive +GCGGACCCGCCGAAAACGCAACCGUGCACAAUUCUGAGCAUGGGCGGGCCAGUACUACAAGCUUCUGGACUCGGU,MASTSRLDALPRVTCPNHPDAILVEDYRAGDMICPECDRVIDVGSEWRTFSNDKATKDPSRVGDSQNPLLSDGDLSTMIGKGTGAASFDEFGNSKYQNRRTMSSSDRAMMNAFKEITTMADRINLPRNIVDRTNNLFKQVYEQKSLKGRANDAIASACLYIACRQEGVPRTFKEICAVSRISKKEIGRCFKLILKALETSVDLITTGDFMSRFCSNLCLPKQVQMAATHIA,positive +CCAGAUUGUCCCCCACCAGAAGUGCAAUGC,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,positive +GGGACGCGTGGTACCGACGGAGGCTTGTTTATGTAGGGATGTAAGGGGATGGGCAATGTGGCGACAGCTT,MQRTKEAVKASDGNLLGDPGRIPLSKRESIKWQRPRFTRQALMRCCLIKWILSSAAPQGSDSSDSELELSTVRHQPEGLDQLQAQTKFTKKELQSLYRGFKNECPTGLVDEDTFKLIYSQFFPQGDATTYAHFLFNAFDADGNGAIHFEDFVVGLSILLRGTVHEKLKWAFNLYDINKDGCITKEEMLAIMKSIYDMMGRHTYPILREDAPLEHVERFFQKMDRNQDGVVTIDEFLETCQKDENIMNSMQLFENVI,positive +GUAAGGGUUCACUCUGCAUCGACAACUGGA,MDSTNYISKLFEYAQRQGQISDIKFEEVGTDGPDHLKTFTLRVVIKGHAYPNGVGKTKKEAKRNAAKHALIGMMETTEQKDASVSCPPSPAPSPAPPVRAVISQPKYVSWLNEHSQKNKLSLKALEGARVGPNNTSQCCRYVVGEKEYPEGFGNTKKEAKEEAAMQVYLELCGGSQTTGTVDENCNGTTGKHKEELNGKVVVLSEKVEHMNMSPAQNVPEQYSFITTEETNFIGILNHYCQKTKRFLDFKLVEKSGPSHNPQFVYKVLIDKREYPDGLGKTAKEAKQQAAQLAWSALQEQSDWNSQVSCRSTVSEEGGLSSLTPSSTWESQDATPSSLSIAGSTSESIIFSDSVNVSSPKDESPVNVKPKIRLAANFQMSPVKTKQEGPNLKGNDLGTLSSGRTSNQPVISRFSSEFDSIENIGKGGFGHVYKARRKLEQKYFAVKIVRSKGKAKREVGALADLQHPNIVRYYTAWLEDTAYRCDTASESDTTSDSGSSSSSEFLYIQMELCDKRTLKVWIDERNAHRKPKRREESLSITQQIVNGVEYIHSKKLLHRDLKPANIMFGMSDGEGKGEVKIGDFGLVTAEDNDNDENLLERTKKTGTVSYMAPEQRNQTSYDRKVDIFALGLIYFEPLWDLSGMEKAKVWNDVRSQRFPQQFNSQFTLENKVIESLLCANPEERPDARQLKTKLNECSRVLTRVHNIHQDNRTI,positive +GGGAGAGGAGAGAACGUUCUACAGCGCCGGUGGGUGGGCAUAGGGUGGAUGCGCUGUCGAUCGAUCGAUCGAUG,MNQVTIQWDAVIALYILFSWCHGGITNINCSGHIWVEPATIFKMGMNISIYCQAAIKNCQPRKLHFYKNGIKERFQITRINKTTARLWYKNFLEPHASMYCTAECPKHFQETLICGKDISSGYPPDIPDEVTCVIYEYSGNMTCTWNAGKLTYIDTKYVVHVKSLETEEEQQYLTSSYINISTDSLQGGKKYLVWVQAANALGMEESKQLQIHLDDIVIPSAAVISRAETINATVPKTIIYWDSQTTIEKVSCEMRYKATTNQTWNVKEFDTNFTYVQQSEFYLEPNIKYVFQVRCQETGKRYWQPWSSLFFHKTPETVPQVTSKAFQHDTWNSGLTVASISTGHLTSDNRGDIGLLLGMIVFAVMLSILSLIGIFNRSFRTGIKRRILLLIPKWLYEDIPNMKNSNVVKMLQENSELMNNNSSEQVLYVDPMITEIKEIFIPEHKPTDYKKENTGPLETRDYPQNSLFDNTTVVYIPDLNTGYKPQISNFLPEGSHLSNNNEITSLTLKPPVDSLDSGNNPRLQKHPNFAFSVSSVNSLSNTIFLGELSLILNQGECSSPDIQNSVEEETTMLLENDSPSETIPEQTLLPDEFVSCLGIVNEELPSINTYFPQNILESHFNRISLLEK,positive +AGCAACCU,PGGVQVSLLKEYYEDGYHIVRDIDSTVGVSISDASLPPRTWNGFLAPKTYKNVYIDTYHNQVFDDIFRTFTIDQHVKLACSLPHGRLRGADKPLIVKEWSGAMTDCAMYLNGRGIGSRFDGSFPSGKPSGACGARSKGSSSELSAQQKKDTLRYIEAQLDAFEVGAGWYFWTW,positive +TATTAGTCATAATATTAGTCATAA,MDHLNEATQGKEHSEMSNNVSDPKGPPAKIARLEQNGSPLGRGRLGSTGAKMQGVPLKHSGHLMKTNLRKGTMLPVFCVVEHYENAIEYDCKEEHAEFVLVRKDMLFNQLIEMALLSLGYSHSSAAQAKGLIQVGKWNPVPLSYVTDAPDATVADMLQDVYHVVTLKIQLHSCPKLEDLPPEQWSHTTVRNALKDLLKDMNQSSLAKECPLSQSMISSIVNSTYYANVSAAKCQEFGRWYKHFKKTKDMMVEMDSLSELSQQGANHVNFGQQPVPGNTAEQPPSPAQLSHGSQPSVRTPLPNLHPGLVSTPISPQLVNQQLVMAQLLNQQYAVNRLLAQQSLNQQYLNHPPPVSRSMNKPLEQQVSTNTEVSSEIYQWVRDELKRAGISQAVFARVAFNRTQGLLSEILRKEEDPKTASQSLLVNLRAMQNFLQLPEAERDRIYQDERERSLNAASAMGPAPLISTPPSRPPQVKTATIATERNGKPENNTMNINASIYDEIQQEMKRAKVSQALFAKVAATKSQGWLCELLRWKEDPSPENRTLWENLSMIRRFLSLPQPERDAIYEQESNAVHHHGDRPPHIIHVPAEQIQQQQQQQQQQQQQQQAPPPPQPQQQPQTGPRLPPRQPTVASPAESDEENRQKTRPRTKISVEALGILQSFIQDVGLYPDEEAIQTLSAQLDLPKYTIIKFFQNQRYYLKHHGKLKDNSGLEVDVAEYKEEELLKDLEESVQDKNTNTLFSVKLEEELSVEGNTDINTDLKD,positive +CTCCTCTGACTGTAACCACGTGCCTAGCGTTTCATTGTCCCTTCTTATTAGGTGATAATAGCATAGGTAGTCCAGAAGCC,MLDLFADAEPWQEPLAAGAVILRRFAFNAAEQLIRDINDVASQSPFRQMVTPGGYTMSVAMTNCGHLGWTTHRQGYLYSPIDPQTNKPWPAMPQSFHNLCQRAATAAGYPDFQPDACLINRYAPGAKLSLHQDKDEPDLRAPIVSVSLGLPAIFQFGGLKRNDPLKRLLLEHGDVVVWGGESRLFYHGIQPLKAGFHPLTIDCRYNLTFRQAGKKE,positive +GGGAUAUCCUCGAGCAUAAGAAACAAGAUAGAUCCUGAAACUGUUUUAAGGUUGGCCGAUCUUCUGCUCGAGAAUGCAUGAAGCGUUCCAUAUUUUU,SHGGLPCQNSQRGKRSFPAVEICKYKGPARIVVSLVTNEDTPRPHAHSLVGKHCKDGLCTVQVGPNDMTASFPNLGILHVTRKDVVPTLKTRILAQHRLYKDLINNSGGEGQWMEPSDQEIEKKAKEMAKDMDLSVVRLCFQTYLPDVKGHFTQPLEPVISVPVFDSKAPNATTLKICRMDKSAGCCTGGEEVYLLCDKVQKEVIQVKFFEVST,positive +CCAAGCAUCAGCUGG,MASNFTQFVLVDNGGTGDVTVAPSNFANGVAEWISSNSRSQAYKVTCSVRQSSAQNRKYTIKVEVPKVATQTVGGVELPVAAWRSYLNMELTIPIFATNSDCELIVKAMQGLLKDGNPIPSAIAANSGIY,positive +CCACAGTACTACCGTATAACATGATGTCAA,MDKLVVNYYEYKHPIINKDLAIGAHGGKKFPTLGAWYDVINEYEFQTRCPIILKNSHRNKHFTFACHLKNCPFKVLLSYAGNAASSETSSPSANNNTNPPGTPDHIHHHSNNMNNEDNDNNNGSNNKVSNDSKLDFVTDDLEYHLANTHPDDTNDKVESRSNEVNGNNDDDADANNIFKQQGVTIKNDTEDDSINKASIDRGLDDESGPTHGNDSGNHRHNEEDDVHTQMTKNYSDVVNDEDINVAIANAVANVDSQSNNKHDGKDDDATNNNDGQDNNTNNDHNNNSNINNNNVGSHGISSHSPSSIRDTSMNLDVFNSATDDIPGPFVVTKIEPYHSHPLEDNLSLGKFILTKIPKILQNDLKFDQILESSYNNSNHTVSKFKVSHYVEESGLLDILMQRYGLTAEDFEKRLLSQIARRITTYKARFVLKKKKMGEYNDLQPSSSSNNNNNNDGELSGTNLRSNSIDYAKHQEISSAGTSSNTTKNVNNNKNDSNDDNNGNNNNDASNLMESVLDKTSSHRYQPKKMPSVNKWSKPDQITHSDVSMVGLDESNDGGNENVHPTLAEVDAQEARETAQLAIDKINSYKRSIDDKNGDGHNNSSRNVVDENLINDMDSEDAHKSKRQHLSDITLEERNEDDKLPHEVAEQLRLLSSHLKEVENLHQNNDDDVDDVMVDVDVESQYNKNTTHHNNHHSQPHHDEEDVAGLIGKADDEEDLSDENIQPELRGQ,positive +GGGAGGACGATGCGGTGACGTAAGAGTGTAATCGATGCAGCCTGGCAGACGACGAGCGGGA,MKEFEVKVASTAFVLVLFSLTINQILASETSTKFRSPVPAPTVPDWNHLPNEGNEENVVSAPKQDGASGGQKPYWTKREKMMKRLHAEPAGNTVRFRCAVDGNPKPQVLWYKNDLIVQKNDRVGGYKYRNQVLILESVVLSDKGNYMCVARNEYGSINHTYQLDVQERSASKPILAEGLPQNKSAYIGDDVTFKCKVYSDAHPHIQWLKSINNHNNAAPNYTVLKAAGVNTTDLDMEVLILKNVSFEEAGEYTCLAGNSIGISHQSAWLSVLPVPPPTTDTITKGIPNETNIIIYVMCGVLVILFGLAVVLVLYYHCYNGKDPPMLVRIENPDNIPPMTKIEHPTMLFGNTQAWQRMCMPMQEPFEFNIQLDLQWELQREDITLVERLDEGFFGQVFKADLVTCNNTRKEKMVCAVKMLKGNRNEKDVLDLLTEMDQMKRVGKHKNIINLLGVCTQNGPLWLVIEYAAQGNLRDYLRRNRPQNTLCNLVLPSEGRNPDDELPVPHGDTLTQKDIVSFAFQVARGLEFLAQKKCIHRDLAARNVLVTEELVMKIADFGLARDIRSCDYYRKHTRGHLPYKWMALEAMSDNIFTHATDVWSFGVLLWEIFSLAGSPYPGIKTHELVKFLRSGERLDKPQYASQEMYRLMRDCWEEDPSKRPNFRTLVEDLDRMLAESSTEVYIDFAAGCEAEYSESSEDESESQNSDEEDDDSVFERMRQIDSLSNGNIPFNEEDSSNSDPYVAPLLQNEENVLQNEHARLRSEA,positive +UCGGACCGGCAAUAAGGGUAUGGCCGUAUAAUCCAGGUCGCCGCUGUCCGA,MSSTESPVPAAAAPAEAVPASTPAPAAEQPAVGNGEQRNNADAANNTSLYVGELDPSVTEAMLFEIFSMIGTVASIRVCRDAVTRRSLGYAYVNFLNAADGERAMEQLNYSLIRNRPCRIMWSQRDPALRRTGQGNIFIKNLDAGIDNKALHDTFAAFGNILSCKVATNETGSLGYGFVHYETAEAAEAAIKHVNGMLLNDKKVYVGHHIPRKERQAKIEETRANFTNVYAKNVDPEVTDDEFEKLFTKFGKITSCVLQRDEDGKSKGFGFVNFEDHNEAQKAVDELHDSDFKGQKLFVARAQKKSEREEELRRSYEAAKNEKLAKFQGVNLYLKNIPESYDDERLREEFAPFGAITSCKIMRAPSGVSRGFGFVCYSAPEEANKAVSEMNGKMLDNRPLYVALAQRKDVRRQQLEAQIMQRNQLRLQQQAAAQGMGYPGPGMYYPQPGAFPGQPGGMVPRPRYAPAGMMPQGMPMAPYGQPGQFPAGMMPQGYRPARPPRGAPNAAGGPAPPAGARPPTGVNGAPRPAGQPVPGQPMPRGPAARPAGRPEADQPGALTAAALAKASPEEQKQMLGEAIYPKVAASQPELAGKLTGMILELPVTELLHLLEESEALDAKVNEALEVLKEYQQNDSAGAEAEANAEAPKTEA,positive +CUCAGAGACAGAGCAGAAACGACAGUUCAAGCCGAA,MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICEVEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASSIVYKKEGEQVEFSFPLAFTVEKLTGSGELWWQAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLPQALPQYAGSGNLTLALEAKTGKLHQEVNLVVMRATQLQKNLTCEVWGPTSPKLMLSLKLENKEAKVSKREKAVWVLNPEAGMWQCLLSDSGQVLLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQAERMSQIKRLLSEKKTCQCPHRFQKTCSPI,positive +CTATAGAGGTGCTCCAGGGCGATAAACTTATGAATATTAA,MKKRKVLIPLMALSTILVSSTGNLEVIQAEVKQENRLLNESESSSQGLLGYYFSDLNFQAPMVVTSSTTGDLSIPSSELENIPSENQYFQSAIWSGFIKVKKSDEYTFATSADNHVTMWVDDQEVINKASNSNKIRLEKGRLYQIKIQYQRENPTEKGLDFKLYWTDSQNKKEVISSDNLQLPELKQKSSNSRKKRSTSAGPTVPDRDNDGIPDSLEVEGYTVDVKNKRTFLSPWISNIHEKKGLTKYKSSPEKWSTASDPYSDFEKVTGRIDKNVSPEARHPLVAAYPIVHVDMENIILSKNEDQSTQNTDSQTRTISKNTSTSRTHTSEVHGNAEVHASFFDIGGSVSAGFSNSNSSTVAIDHSLSLAGERTWAETMGLNTADTARLNANIRYVNTGTAPIYNVLPTTSLVLGKNQTLATIKAKENQLSQILAPNNYYPSKNLAPIALNAQDDFSSTPITMNYNQFLELEKTKQLRLDTDQVYGNIATYNFENGRVRVDTGSNWSEVLPQIQETTARIIFNGKDLNLVERRIAAVNPSDPLETTKPDMTLKEALKIAFGFNEPNGNLQYQGKDITEFDFNFDQQTSQNIKNQLAELNATNIYTVLDKIKLNAKMNILIRDKRFHYDRNNIAVGADESVVKEAHREVINSSTEGLLLNIDKDIRKILSGYIVEIEDTEGLKEVINDRYDMLNISSLRQDGKTFIDFKKYNDKLPLYISNPNYKVNVYAVTKENTIINPSENGDTSTNGIKKILIFSKKGYEIG,positive +CCGCGCAAGGGGUAACCGGAGAAUAUUUGG,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,positive +GGGACGCGTGGTACCAAAGAGGCTGCGCGGAAGTGAGGGTGTTGGTTACGAAGGTTGGTGTGTGAAGCTT,MQRTKEAVKASDGNLLGDPGRIPLSKRESIKWQRPRFTRQALMRCCLIKWILSSAAPQGSDSSDSELELSTVRHQPEGLDQLQAQTKFTKKELQSLYRGFKNECPTGLVDEDTFKLIYSQFFPQGDATTYAHFLFNAFDADGNGAIHFEDFVVGLSILLRGTVHEKLKWAFNLYDINKDGCITKEEMLAIMKSIYDMMGRHTYPILREDAPLEHVERFFQKMDRNQDGVVTIDEFLETCQKDENIMNSMQLFENVI,positive +CCACAGUCACUGGG,MASNFTQFVLVDNGGTGDVTVAPSNFANGVAEWISSNSRSQAYKVTCSVRQSSAQNRKYTIKVEVPKVATQTVGGVELPVAAWRSYLNMELTIPIFATNSDCELIVKAMQGLLKDGNPIPSAIAANSGIY,positive +GAAGGGACGAUAAAGAGGAAUCGAACAACAAGUGGCUGGC,IMEIRTVAVGIVAIKGVESEYYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHSGGEMFVALNQKGLPVKGKKTKKEQKTAHFLPMAIT,positive +GGGAGAAUUCAACUGCCAUCUAUAGAGGAUGAAGCCAAGCUCCUAGAAGGCCUCUUGCCUAAACCGAGUCCAGAAGCUUGUAGU,MSSSQKKAGGKAGKPTKRSQNYAALRKAQLPKPPALKVPVVKPTNTILPQTGCVWQSLGTPLSLSSFNGLGARFLYSFLKDFVGPRILEEDLIYRMVFSITPSHAGTFCLTDDVTTEDGRAVAHGNPMQEFPHGAFHANEKFGFELVFTAPTHAGMQNQNFKHSYAVALCLDFDAQPEGSKNPSFRFNEVWVERKAFPRAGPLRSLITVGLFDEADDLDRH,positive +UAUUAUGCCUUUAGCUAGCGCAUUCUGUGGGGUGGGUGGA,MEDDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKEEIAEVANEIESLGSTEERKNMQRNKQVAMGRKKFNMDPKKGIQFLIENGLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERDEFSIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNTGVFQSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIKNEPFKIPVWFFLQNLYESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEDWIKCIKAAISRDPFYEMLAARKKKVSSTKRH,positive +CGCCGTATTAAGATTGGGAGACCTGGTAGA,AKVLVVLLLFAGVDAETHVTGGSAAHAASTFAGLFSPGAKQDIQLINTNGSWHINRTA,positive +BCGAGGCGTGTGCAAGGCGTGTTGTTCAAAGGTGTGTGTGT,MVDREQLVQKARLAEQAERYDDMAAAMKNVTELNEPLSNEERNLLSVAYKNVVGARRSSWRVISSIEQKTSADGNEKKIEMVRAYREKIEKELEAVCQDVLSLLDNYLIKNCSETQYESKVFYLKMKGDYYRYLAEVATGEKRATVVESSEKAYSEAHEISKEHMQPTHPIRLGLALNYSVFYYEIQNAPEQACHLAKTAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDQQDDDGGEGNN,positive +GTCAAGNACGCGAACCCCGCATTCCCAAGAACGGCAACCCT,MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP,positive +AGCCGUCGCUAGUUUGAUUCCGUGUGUUAGUGGUU,MAWYWWRRRRRRGWWKPRRRRWRRRRARRRGPARRHRARRRIVRHPCNGQTSSGNRVPRSVQAVDPKYVSLQLVWHSWDFRRGLFGQAGIKRMQQESDALTLSPVHRPKRPKRDTQVKEKTPEKDSDSAVQLRRLQPWIHSSQETKDEEEEIPEGPVQEQLLQQLQQQRLLRVQLESIAQEVLKIRRGHSLHPLLSSHA,positive +ATTTGCAACACTTACCACTAAAAGGGCCGACGACCGATGATGTTAGGTCCAGTGCTTTCT,MRKIVVAAIAVSLTTVSITASASADPSKDSKAQVSAAEAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKVKPSAASIDAAKKAGVNNGNPLDAVQQ,positive +GACGGCAACCCGUUAUAACCUCCCACUGGCUAUCCCGUUAAGCUUCCCUA,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,positive +CAUGAGGUCGUAUGCGAUCUGCAUCGACAGCUAGGCGGAGCUAUCG,MDSTNYISKLFEYAQRQGQISDIKFEEVGTDGPDHLKTFTLRVVIKGHAYPNGVGKTKKEAKRNAAKHALIGMMETTEQKDASVSCPPSPAPSPAPPVRAVISQPKYVSWLNEHSQKNKLSLKALEGARVGPNNTSQCCRYVVGEKEYPEGFGNTKKEAKEEAAMQVYLELCGGSQTTGTVDENCNGTTGKHKEELNGKVVVLSEKVEHMNMSPAQNVPEQYSFITTEETNFIGILNHYCQKTKRFLDFKLVEKSGPSHNPQFVYKVLIDKREYPDGLGKTAKEAKQQAAQLAWSALQEQSDWNSQVSCRSTVSEEGGLSSLTPSSTWESQDATPSSLSIAGSTSESIIFSDSVNVSSPKDESPVNVKPKIRLAANFQMSPVKTKQEGPNLKGNDLGTLSSGRTSNQPVISRFSSEFDSIENIGKGGFGHVYKARRKLEQKYFAVKIVRSKGKAKREVGALADLQHPNIVRYYTAWLEDTAYRCDTASESDTTSDSGSSSSSEFLYIQMELCDKRTLKVWIDERNAHRKPKRREESLSITQQIVNGVEYIHSKKLLHRDLKPANIMFGMSDGEGKGEVKIGDFGLVTAEDNDNDENLLERTKKTGTVSYMAPEQRNQTSYDRKVDIFALGLIYFEPLWDLSGMEKAKVWNDVRSQRFPQQFNSQFTLENKVIESLLCANPEERPDARQLKTKLNECSRVLTRVHNIHQDNRTI,positive +TATTAGTACTAATATTAGTACTAA,MDHLNEATQGKEHSEMSNNVSDPKGPPAKIARLEQNGSPLGRGRLGSTGAKMQGVPLKHSGHLMKTNLRKGTMLPVFCVVEHYENAIEYDCKEEHAEFVLVRKDMLFNQLIEMALLSLGYSHSSAAQAKGLIQVGKWNPVPLSYVTDAPDATVADMLQDVYHVVTLKIQLHSCPKLEDLPPEQWSHTTVRNALKDLLKDMNQSSLAKECPLSQSMISSIVNSTYYANVSAAKCQEFGRWYKHFKKTKDMMVEMDSLSELSQQGANHVNFGQQPVPGNTAEQPPSPAQLSHGSQPSVRTPLPNLHPGLVSTPISPQLVNQQLVMAQLLNQQYAVNRLLAQQSLNQQYLNHPPPVSRSMNKPLEQQVSTNTEVSSEIYQWVRDELKRAGISQAVFARVAFNRTQGLLSEILRKEEDPKTASQSLLVNLRAMQNFLQLPEAERDRIYQDERERSLNAASAMGPAPLISTPPSRPPQVKTATIATERNGKPENNTMNINASIYDEIQQEMKRAKVSQALFAKVAATKSQGWLCELLRWKEDPSPENRTLWENLSMIRRFLSLPQPERDAIYEQESNAVHHHGDRPPHIIHVPAEQIQQQQQQQQQQQQQQQAPPPPQPQQQPQTGPRLPPRQPTVASPAESDEENRQKTRPRTKISVEALGILQSFIQDVGLYPDEEAIQTLSAQLDLPKYTIIKFFQNQRYYLKHHGKLKDNSGLEVDVAEYKEEELLKDLEESVQDKNTNTLFSVKLEEELSVEGNTDINTDLKD,positive +TCCGGCGCGCTGAGTGCCGGTTATCCTCGT,MGLLGILCFLIFLGKTWGQEQTYVISAPKIFRVGASENIVIQVYGYTEAFDATISIKSYPDKKFSYSSGHVHLSSENKFQNSAILTIQPKQLPGGQNPVSYVYLEVVSKHFSKSKRMPITYDNGFLFIHTDKPVYTPDQSVKVRVYSLNDDLKPAKRETVLTFIDPEGSEVDMVEEIDHIGIISFPDFKIPSNPRYGMWTIKAKYKEDFSTTGTAYFEVKEYVLPHFSVSIEPEYNFIGYKNFKNFEITIKARYFYNKVVTEADVYITFGIREDLKDDQKEMMQTAMQNTMLINGIAQVTFDSETAVKELSYYSLEDLNNKYLYIAVTVIESTGGFSEEAEIPGIKYVLSPYKLNLVATPLFLKPGIPYPIKVQVKDSLDQLVGGVPVTLNAQTIDVNQETSDLDPSKSVTRVDDGVASFVLNLPSGVTVLEFNVKTDAPDLPEENQAREGYRAIAYSSLSQSYLYIDWTDNHKALLVGEHLNIIVTPKSPYIDKITHYNYLILSKGKIIHFGTREKFSDASYQSINIPVTQNMVPSSRLLVYYIVTGEQTAELVSDSVWLNIEEKCGNQLQVHLSPDADAYSPGQTVSLNMATGMDSWVALAAVDSAVYGVQRGAKKPLERVFQFLEKSDLGCGAGGGLNNANVFHLAGLTFLTNANADDSQENDEPCKEILRPRRTLQKKIEEIAAKYKHSVVKKCCYDGACVNNDETCEQRAARISLGPRCIKAFTECCVVASQLRANISHKDMQLGRLHMKTLLPVSKPEIRSYFPESWLWEVHLVPRRKQLQFALPDSLTTWEIQGVGISNTGICVADTVKAKVFKDVFLEMNIPYSVVRGEQIQLKGTVYNYRTSGMQFCVKMSAVEGICTSESPVIDHQGTKSSKCVRQKVEGSSSHLVTFTVLPLEIGLHNINFSLETWFGKEILVKTLRVVPEGVKRESYSGVTLDPRGIYGTISRRKEFPYRIPLDLVPKTEIKRILSVKGLLVGEILSAVLSQEGINILTHLPKGSAEAELMSVVPVFYVFHYLETGNHWNIFHSDPLIEKQKLKKKLKEGMLSIMSYRNADYSYSVWKGGSASTWLTAFALRVLGQVNKYVEQNQNSICNSLLWLVENYQLDNGSFKENSQYQPIKLQGTLPVEARENSLYLTAFTVIGIRKAFDICPLVKIDTALIKADNFLLENTLPAQSTFTLAISAYALSLGDKTHPQFRSIVSALKREALVKGNPPIYRFWKDNLQHKDSSVPNTGTARMVETTAYALLTSLNLKDINYVNPVIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVKQLRLSMDIDVSYKHKGALHNYKMTDKNFLGRPVEVLLNDDLIVSTGFGSGLATVHVTTVVHKTSTSEEVCSFYLKIDTQDIEASHYRGYGNSDYKRIVACASYKPSREESSSGSSHAVMDISLPTGISANEEDLKALVEGVDQLFTDYQIKDGHVILQLNSIPSSDFLCVRFRIFELFEVGFLSPATFTVYEYHRPDKQCTMFYSTSNIKIQKVCEGAACKCVEADCGQMQEELDLTISAETRKQTACKPEIAYAYKVSITSITVENVFVKYKATLLDIYKTGEAVAEKDSEITFIKKVTCTNAELVKGRQYLIMGKEALQIKYNFSFRYIYPLDSLTWIEYWPRDTTCSSCQAFLANLDEFAEDIFLNGC,positive +ACATGTGATGATATATCGTGTCTCGTGATA,MDKLVVNYYEYKHPIINKDLAIGAHGGKKFPTLGAWYDVINEYEFQTRCPIILKNSHRNKHFTFACHLKNCPFKVLLSYAGNAASSETSSPSANNNTNPPGTPDHIHHHSNNMNNEDNDNNNGSNNKVSNDSKLDFVTDDLEYHLANTHPDDTNDKVESRSNEVNGNNDDDADANNIFKQQGVTIKNDTEDDSINKASIDRGLDDESGPTHGNDSGNHRHNEEDDVHTQMTKNYSDVVNDEDINVAIANAVANVDSQSNNKHDGKDDDATNNNDGQDNNTNNDHNNNSNINNNNVGSHGISSHSPSSIRDTSMNLDVFNSATDDIPGPFVVTKIEPYHSHPLEDNLSLGKFILTKIPKILQNDLKFDQILESSYNNSNHTVSKFKVSHYVEESGLLDILMQRYGLTAEDFEKRLLSQIARRITTYKARFVLKKKKMGEYNDLQPSSSSNNNNNNDGELSGTNLRSNSIDYAKHQEISSAGTSSNTTKNVNNNKNDSNDDNNGNNNNDASNLMESVLDKTSSHRYQPKKMPSVNKWSKPDQITHSDVSMVGLDESNDGGNENVHPTLAEVDAQEARETAQLAIDKINSYKRSIDDKNGDGHNNSSRNVVDENLINDMDSEDAHKSKRQHLSDITLEERNEDDKLPHEVAEQLRLLSSHLKEVENLHQNNDDDVDDVMVDVDVESQYNKNTTHHNNHHSQPHHDEEDVAGLIGKADDEEDLSDENIQPELRGQ,positive +ACACCCACCGCAGGCAGACGCAACGCCTCGGAGACTAGCC,MKPGGNTIVIWMYAVATWLCFGSTSGWSFTLEDNNIFPKQYPIINFTTAGATVQSYTNFIRAVRGRLTTGADVRHEIPVLPNRVGLPINQRFILVELSNHAELSVTLALDVTNAYVVGYRAGNSAYFFHPDNQEDAEAITHLFTDVQNRYTFAFGGNYDRLEQLAGNLRENIELGNGPLEEAISALYYYSTGGTQLPTLARSFIICIQMISEAARFQYIEGEMRTRIRYNRRSAPDPSVITLENSWGRLSTAIQESNQGAFASPIQLQRRNGSKFSVYDVSILIPIIALMVYRCAPPPSSQFSLLIRPVVPNFNADVCMDPEPIVRIVGRNGLCVDVRDGRFHNGNAIQLWPCKSNTDANQLWTLKRDNTIRSNGKCLTTYGYSPGVYVMIYDCNTAATDATRWQIWDNGTIINPRSSLVLAATSGNSGTTLTVQTNIYAVSQGWLPTNNTQPFVTTIVGLYGLCLQANSGQVWIEDCSSEKAEQQWALYADGSIRPQQNRDNCLTSDSNIRETVVKILSCGPASSGQRWMFKNDGTILNLYSGLVLDVRASDPSLKQIILYPLHGDPNQIWLPLF,positive +CCAGACGUUCUCGCCCCGCCGAUCAUCAGCGCUGGCCCUAU,MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYTFLLPEMDNCRSSSSPYVSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQDNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVLVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF,positive +GCGCAAACCCGAAGAAUGCCCAAAUUGAUCCAGAGCAAGUGGGAAUGAUAUAAAGUACCUGGUCCUGG,MAGRSGDSDEELLKAVRLIKFLYQSNPPPNPEGTRQARRNRRRRWRERQRQIHSISERILSTYLGRSAEPVPLQLPPLERLTLDCNEDCGTSGTQGVGSPQILVESPTILESGAKE,positive +GGUCGAUAAAAACCCCAGAGGCGCAACGC,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,positive +TAGTGATGTTCGTGGCGAATGATACACTTA,MDKLVVNYYEYKHPIINKDLAIGAHGGKKFPTLGAWYDVINEYEFQTRCPIILKNSHRNKHFTFACHLKNCPFKVLLSYAGNAASSETSSPSANNNTNPPGTPDHIHHHSNNMNNEDNDNNNGSNNKVSNDSKLDFVTDDLEYHLANTHPDDTNDKVESRSNEVNGNNDDDADANNIFKQQGVTIKNDTEDDSINKASIDRGLDDESGPTHGNDSGNHRHNEEDDVHTQMTKNYSDVVNDEDINVAIANAVANVDSQSNNKHDGKDDDATNNNDGQDNNTNNDHNNNSNINNNNVGSHGISSHSPSSIRDTSMNLDVFNSATDDIPGPFVVTKIEPYHSHPLEDNLSLGKFILTKIPKILQNDLKFDQILESSYNNSNHTVSKFKVSHYVEESGLLDILMQRYGLTAEDFEKRLLSQIARRITTYKARFVLKKKKMGEYNDLQPSSSSNNNNNNDGELSGTNLRSNSIDYAKHQEISSAGTSSNTTKNVNNNKNDSNDDNNGNNNNDASNLMESVLDKTSSHRYQPKKMPSVNKWSKPDQITHSDVSMVGLDESNDGGNENVHPTLAEVDAQEARETAQLAIDKINSYKRSIDDKNGDGHNNSSRNVVDENLINDMDSEDAHKSKRQHLSDITLEERNEDDKLPHEVAEQLRLLSSHLKEVENLHQNNDDDVDDVMVDVDVESQYNKNTTHHNNHHSQPHHDEEDVAGLIGKADDEEDLSDENIQPELRGQ,positive +GCATCAAGACCCTGCGCATGGAGCCTTCTGCAACCACTCC,MPSNQEARLFLAVLVLAQVLPILVDSAAEKGFKQAFWQPLCQVSEELDDQPKGALFTLQAAASKIQKMRDAALRASIYAEINHGTNRAKAAVIVANHYAMKADSGLEALKQTLSSQEVTATATASYLKGRIDEYLNLLLQTKESGTSGCMMDTSGTNTVTKAGGTIGGVPCKLQLSPIQPKRPAATYLGKAGYVGLTRQADAANNFHDNDAECRLASGHNTNGLGKSGQLSAAVTMAAGYVTVANSQTAVTVQALDALQEASGAAHQPWIDAWKAKKALTGAETAEFRNETAGIAGKTGVTKLVEEALLKKKDSEASEIQTELKKYFSGHENEQWTAIEKLISEQPVAQNLVGDNQPTKLGELEGNAKLTTILAYYRMETAGKFEVLTQKHKPAESQQQAAETEGSCNKKDQNECKSPCKWHNDAENKKCTLDKEEAKKVADETAKDGKTGNTNTTGSSNSFVISKTPLWLAVLLF,positive +ACAUUCCAAAUUACCCACCCACUGCUCCUAUCUG,MAVAQELYGFPASKLDSFVAQWLQPTREWKEEVLETVQTVEQFLRQENFREDRGPARDVRVLKVLKVGCFGNGTVLRSTTDVELVVFLSCFHSFQEEAKHHQAVLRLIQKRMYYCQELMDLGLSNLSVTNRVPSSLIFTIQTRETWETITVTVVPAYRALGPSCPSSEVYANLIKANGYPGNFSPSFSELQRNFVKHRPTKLKSLLRLVKHWYQQYVRDKCPRANLPPLYALELLTVYAWEAGTREDANFRLDEGLATVMELLQDHELLCIYWTKHYTLQHPVIEACVRRQLRGQRPIILDPADPTNNVAEGYRWDIVAQRANQCLKQDCCYDNRDSPVPSWRVKRAPDIQVTVQEWGHSDLTFWVNPYEPIKKLKEKIQLSQGYLGLQRLSFQEPGGERQLIRSHCTLAYYGIFCDTHICLLDTISPEIQVFVKNPDGRSHAYAIHPLDYVLNLKQQIEDRQGLRCQEQRLEFQGHILEDWFDFKSYGIQDSVTVILSKTTEGAAPFVPS,positive +AATACCCGCCCTTCGGTGCAAAGCACCGAAGGGCGGG,WPLTEEKIKALVEICXEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEEFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDXIIYQYMDDLYVGSDLEIGQHRTKVEELRQHLLXWGFTTPDKKHQKEPPFLWMGYELHP,positive +UCGGGGGGGUUGUUCGUGGAAAAUGCUUGCG,MSKRKAPQETLNGGITDMLVELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVTGIGPSAARKLVDEGIKTLEDLRKNEDKLNHHQRIGLKYFEDFEKRIPREEMLQMQDIVLNEVKKLDPEYIATVCGSFRRGAESSGDMDVLLTHPNFTSESSKQPKLLHRVVEQLQKVRFITDTLSKGETKFMGVCQLPSENDENEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEQDIFDYIQWRYREPKDRSE,positive +CCGACCTCCATGGAAACATTCTGCGACTACTTACTGGCC,MAIPKELLVLLLGIAILSKVAECAAFGSRRGLVETVFDVTRFGARPNTPADSTRGLMMAWRSACQSPGPAKVVIPPGTYTTGETIFQGPCTSPRPITIEIQGTLLSNTDMSLYTRAAWISIEHVDGIVITGGGTLNGQGKSSWQFADKSGSTPPLPSSLVFQTVRSSSIKNLNFVDAKGVHLKITDSSDISVSNIKITAPGDSPNTDGLHISDTINVNVTDSTIGTGDDCISIGDGNSNVYISNINCGPGHGISIGSLGKRLDETDVKGVTVRNCTFRGTTNGARIKTYMGSPSLQVSGVVYEDIILDNVKNPIVIDQHYHSKNRNEPSRVKLVDIHFRNIRGTTTSKIPVLLNCSEALPCEGVELVDIDLAPVGSIGPLLPATCQNAKTILNGKNNPPAC,positive +CAUACCAUCCCCAUUUUCGCAAUGAAAAG,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,positive +GGUUGGGUUGUCGUAGAUAGAGCGCUUCAA,MSKRKAPQETLNGGITDMLVELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVTGIGPSAARKLVDEGIKTLEDLRKNEDKLNHHQRIGLKYFEDFEKRIPREEMLQMQDIVLNEVKKLDPEYIATVCGSFRRGAESSGDMDVLLTHPNFTSESSKQPKLLHRVVEQLQKVRFITDTLSKGETKFMGVCQLPSENDENEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEQDIFDYIQWRYREPKDRSE,positive +GGGAGAGGAGAGAACGUUCUACGUCGUGAGUAAUGGCUCGUAGAUGAGGUCGCUGUCGAUCGAUCGAUCGAUG,ASFTCLAIWALASAGVVPLVLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAAFFFVPVIISTVCYVSIIRCLSSSAVANRSKK,positive +ACGCGCTAGGATCAAAGCTGCACTGAAGTG,MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA,positive +CAUGAGGUCUAUCACUGCAUCGACAGCUAGGCGGACAAUG,MDSTNYISKLFEYAQRQGQISDIKFEEVGTDGPDHLKTFTLRVVIKGHAYPNGVGKTKKEAKRNAAKHALIGMMETTEQKDASVSCPPSPAPSPAPPVRAVISQPKYVSWLNEHSQKNKLSLKALEGARVGPNNTSQCCRYVVGEKEYPEGFGNTKKEAKEEAAMQVYLELCGGSQTTGTVDENCNGTTGKHKEELNGKVVVLSEKVEHMNMSPAQNVPEQYSFITTEETNFIGILNHYCQKTKRFLDFKLVEKSGPSHNPQFVYKVLIDKREYPDGLGKTAKEAKQQAAQLAWSALQEQSDWNSQVSCRSTVSEEGGLSSLTPSSTWESQDATPSSLSIAGSTSESIIFSDSVNVSSPKDESPVNVKPKIRLAANFQMSPVKTKQEGPNLKGNDLGTLSSGRTSNQPVISRFSSEFDSIENIGKGGFGHVYKARRKLEQKYFAVKIVRSKGKAKREVGALADLQHPNIVRYYTAWLEDTAYRCDTASESDTTSDSGSSSSSEFLYIQMELCDKRTLKVWIDERNAHRKPKRREESLSITQQIVNGVEYIHSKKLLHRDLKPANIMFGMSDGEGKGEVKIGDFGLVTAEDNDNDENLLERTKKTGTVSYMAPEQRNQTSYDRKVDIFALGLIYFEPLWDLSGMEKAKVWNDVRSQRFPQQFNSQFTLENKVIESLLCANPEERPDARQLKTKLNECSRVLTRVHNIHQDNRTI,positive +UCCAAACCCCGUUGAGAGUUGAUCCGGUCUAGGGAAUGGAAAGAAGUAGGUAUCGAAGAGAAUGUACCCU,MAGRSGDSDEELLKAVRLIKFLYQSNPPPNPEGTRQARRNRRRRWRERQRQIHSISERILSTYLGRSAEPVPLQLPPLERLTLDCNEDCGTSGTQGVGSPQILVESPTILESGAKE,positive +TCAAAAGGGGTGATTGCTTGCACAATGACAGGGTAGGACA,MSMSPKHTTPFSVSDILSPLEESYKKVGMEGGGLGAPLAAYRQGQAAPPAAAMQQHAVGHHGAVTAAYHMTAAGVPQLSHSAVGGYCNGNLGNMSELPPYQDTMRNSASGPGWYGANPDPRFPAISRFMGPASGMNMSGMGGLGSLGDVSKNMAPLPSAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGGGGGGGAGCPQQQQAQQQSPRRVAVPVLVKDGKPCQAGAPAPGAGSLQGHAQQQAQQQAQAAQAAAAAISVGSGGPGLGAHPGHQPGSAGQSPDLAHHAASPAALQGQVSSLSHLNSSGSDYGTMSCSTLLYGRTW,positive +AATACCCCCCCTTCGGTGCCTCTTCAGTTAAAAATAACTGAAGAGGCACCGAAGGGGGGG,WPLTEEKIKALVEICXEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEEFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDXIIYQYMDDLYVGSDLEIGQHRTKVEELRQHLLXWGFTTPDKKHQKEPPFLWMGYELHP,positive +TGGGGGTCGGGATACGGTCAGTGGTGGTGAGTGGTAACGG,MKPGGNTIVIWMYAVATWLCFGSTSGWSFTLEDNNIFPKQYPIINFTTAGATVQSYTNFIRAVRGRLTTGADVRHEIPVLPNRVGLPINQRFILVELSNHAELSVTLALDVTNAYVVGYRAGNSAYFFHPDNQEDAEAITHLFTDVQNRYTFAFGGNYDRLEQLAGNLRENIELGNGPLEEAISALYYYSTGGTQLPTLARSFIICIQMISEAARFQYIEGEMRTRIRYNRRSAPDPSVITLENSWGRLSTAIQESNQGAFASPIQLQRRNGSKFSVYDVSILIPIIALMVYRCAPPPSSQFSLLIRPVVPNFNADVCMDPEPIVRIVGRNGLCVDVRDGRFHNGNAIQLWPCKSNTDANQLWTLKRDNTIRSNGKCLTTYGYSPGVYVMIYDCNTAATDATRWQIWDNGTIINPRSSLVLAATSGNSGTTLTVQTNIYAVSQGWLPTNNTQPFVTTIVGLYGLCLQANSGQVWIEDCSSEKAEQQWALYADGSIRPQQNRDNCLTSDSNIRETVVKILSCGPASSGQRWMFKNDGTILNLYSGLVLDVRASDPSLKQIILYPLHGDPNQIWLPLF,positive +CGCGGATCCTGCAGCTCGAGTGGGTAAACAACAACATGTTGACATCGCGGCTCTAGAAGCTTGTCGAC,AKTALQVPLPHPMQMNALGGYSPASTCNGYGRMGLHQEKLPSDLDGMFIERLDCDMESIIRNDLMDGDTLDFNFDNVLPNQSFPHSVKTTTHSWVSG,positive +UCUACCGCCUGCCCUAGCCGAA,MAKGEFIRTKPHVNVGTIGHVDHGKTTLTAALTYVAAAENPNVEVKDYGDIDKAPEERARGITINTAHVEYETAKRHYSHVDCPGHADYIKNMITGAAQMDGAILVVSAADGPMPQTREHILLARQVGVPYIVVFMNKVDMVDDPELLDLVEMEVRDLLNQYEFPGDEVPVIRGSALLALEEMHKNPKTKRGENEWVDKIWELLDAIDEYIPTPVRDVDKPFLMPVEDVFTITGRGTVATGRIERGKVKVGDEVEIVGLAPETRKTVVTGVEMHRKTLQEGIAGDNVGLLLRGVSREEVERGQVLAKPGSITPHTKFEASVYILKKEEGGRHTGFFTGYRPQFYFRTTDVTGVVRLPQGVEMVMPGDNVTFTVELIKPVALEEGLRFAIREGGRTVGAGVVTKILE,positive +UGCGAUAAGGUGGUAGCGACAGUGAUAGAAGC,MDSTNYISKLFEYAQRQGQISDIKFEEVGTDGPDHLKTFTLRVVIKGHAYPNGVGKTKKEAKRNAAKHALIGMMETTEQKDASVSCPPSPAPSPAPPVRAVISQPKYVSWLNEHSQKNKLSLKALEGARVGPNNTSQCCRYVVGEKEYPEGFGNTKKEAKEEAAMQVYLELCGGSQTTGTVDENCNGTTGKHKEELNGKVVVLSEKVEHMNMSPAQNVPEQYSFITTEETNFIGILNHYCQKTKRFLDFKLVEKSGPSHNPQFVYKVLIDKREYPDGLGKTAKEAKQQAAQLAWSALQEQSDWNSQVSCRSTVSEEGGLSSLTPSSTWESQDATPSSLSIAGSTSESIIFSDSVNVSSPKDESPVNVKPKIRLAANFQMSPVKTKQEGPNLKGNDLGTLSSGRTSNQPVISRFSSEFDSIENIGKGGFGHVYKARRKLEQKYFAVKIVRSKGKAKREVGALADLQHPNIVRYYTAWLEDTAYRCDTASESDTTSDSGSSSSSEFLYIQMELCDKRTLKVWIDERNAHRKPKRREESLSITQQIVNGVEYIHSKKLLHRDLKPANIMFGMSDGEGKGEVKIGDFGLVTAEDNDNDENLLERTKKTGTVSYMAPEQRNQTSYDRKVDIFALGLIYFEPLWDLSGMEKAKVWNDVRSQRFPQQFNSQFTLENKVIESLLCANPEERPDARQLKTKLNECSRVLTRVHNIHQDNRTI,positive +GATACACGGGCGGAGGAGGTGGGGGGGGGTAGGTGGGTAT,MSMSPKHTTPFSVSDILSPLEESYKKVGMEGGGLGAPLAAYRQGQAAPPAAAMQQHAVGHHGAVTAAYHMTAAGVPQLSHSAVGGYCNGNLGNMSELPPYQDTMRNSASGPGWYGANPDPRFPAISRFMGPASGMNMSGMGGLGSLGDVSKNMAPLPSAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGGGGGGGAGCPQQQQAQQQSPRRVAVPVLVKDGKPCQAGAPAPGAGSLQGHAQQQAQQQAQAAQAAAAAISVGSGGPGLGAHPGHQPGSAGQSPDLAHHAASPAALQGQVSSLSHLNSSGSDYGTMSCSTLLYGRTW,positive +UAUAUAUGUGUGUCUAUCGUCACUUGUAUGUCAAAUAUU,MAWYWWRRRRRRGWWKPRRRRWRRRRARRRGPARRHRARRRIVRHPCNGQTSSGNRVPRSVQAVDPKYVSLQLVWHSWDFRRGLFGQAGIKRMQQESDALTLSPVHRPKRPKRDTQVKEKTPEKDSDSAVQLRRLQPWIHSSQETKDEEEEIPEGPVQEQLLQQLQQQRLLRVQLESIAQEVLKIRRGHSLHPLLSSHA,positive +AUUUCUCUGAGAUGUUCGCAAGCGGGCCAGUCCCCUGAGCCGAUAUUUCAUACCACAAGAAAUGUGGCGCUCCGCGGUUGGUGAGCAUGCUCGGUCCGUCCGAGAAGCCUUAAAACUGCGACGACACAUUCACCUUGAACCAAGGGUUCAAGGGUUACAGCCUGCGGCGGCAUCUCGGAGAUUCC,SRWDSTQQRAVLAAAVEIMVKFSSQPHLAQVVAEDLLSPSVMDVGDFKISITEGLPSGVPCTSQWNSIAHWLLTLCALSETTNLSPDIIQANSLFSFYG,positive +CAUUGGCCAAUUCCUUGAAUCUCGACUGCUCGGUAGAAUAGACCUUACCA,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,positive +GGGAGGACGAUGCGGAUCAGCCAUGUUUACGUCACUCCUUGUCAAUCCUCAUCGGCAGACGACUCGCCCGA,MHRPQRQQWIANGCAPKWRAMMRLAAAVAVLVVVTTLATAATAAGAKNEHQQQQQQQAWMESFPPMSADFPAGPALSDAEAAFLQVPEAERCRAHLKYLTSLPHVAGTPGDYETAEYVLNQFKSFGLDAVIQNETVLLTAPVEAASAKLYSADGTTLVYAAALSEDLLDPTADTPYRNHSFLGYSPTGSAAGPLVYVNYGSTEDFEYLVAQGVNLTGAIAIARYGSIFRGLKALNAQTHGMAGLIIYSDPSDDGYAQGQLYPNGPWRPESGIQRGSVVFNSLCGGDPGRGVDKCGIPLEDLIPSIPVLPMGYGDAVQFLSHIVGAPAPASWQGALPFQYNIGPGAFARIATNNTQYTTDIWNVVAYINGTDPVEGEDYVILGNHRDAWVYGAVDPNSGTAALLEIARAYGVLLQGGWQPKRGLVLTSWDGEEYGLLGSTAFGERFADDLILHAVAYLNIDTAVMGPQLWVTLVPSLLTHFRQTAALVKDPVTGNPLSVEWDGSYDIMGSGSDYTVFLDALGVASGDLLFGGAYGVYHSVFDSFNWMETQGDPTFQYHEACAQIFGLVGLRLADARILPFNYTEYAYAISTFYLPQVQQLATDAKLPVDFTALTNAAQQFASGASKIMSRVEQAYNNPNYNVVDLNSRLFLAERQFTDPNGIINRKWFKHTVFAPDRENGYDASSFPGIVDMIRTGNATLAQQAITSAATALSNVGTFLSY,positive +ACAGATACGGAACTACAGAGGTCAATTACGGTGGCCACGC,MAIPKELLVLLLGIAILSKVAECAAFGSRRGLVETVFDVTRFGARPNTPADSTRGLMMAWRSACQSPGPAKVVIPPGTYTTGETIFQGPCTSPRPITIEIQGTLLSNTDMSLYTRAAWISIEHVDGIVITGGGTLNGQGKSSWQFADKSGSTPPLPSSLVFQTVRSSSIKNLNFVDAKGVHLKITDSSDISVSNIKITAPGDSPNTDGLHISDTINVNVTDSTIGTGDDCISIGDGNSNVYISNINCGPGHGISIGSLGKRLDETDVKGVTVRNCTFRGTTNGARIKTYMGSPSLQVSGVVYEDIILDNVKNPIVIDQHYHSKNRNEPSRVKLVDIHFRNIRGTTTSKIPVLLNCSEALPCEGVELVDIDLAPVGSIGPLLPATCQNAKTILNGKNNPPAC,positive +AAGACGGCCCGGUAUGUAGCCGGAGAUCCGAGACUUGCU,MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC,positive +GAAGCUUACAAGAAGGACAGCACGAAUAAAACCUGCGUAAAUCCGCCCCAUUUGUGUAAGGGUAGUGGGUCGAAUUCCGCUCA,XQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGSTGSPGPGYGYSNYGFPPYGGITFHPGVTKSNAGVTHGTINTKFKNGPKDCAKSDDEESLTLPEKETEGEGPSLPMACTKTEPIALASTMEDKEQDMGFQDNLFLEKALQLARRHANALFDYAVTGDVKMLLAVQRHLTAVQDENGDSVLHLAIIHLHAQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRVGADLSLLDRWGNSVLHLAAKEGHDRILSILLKSRKAAPLIDHPNGEGLNAIHIAVMSNSLPCLLLLVAAGAEVNAQEQKSGRTALHLAVEYDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWEKAGEDEGVVPGTTPLDMAANWQVFDILNGKPYEPVFTSDDILPQGDMKQLTEDTRLQLCKLLEIPDPDKNWATLAQKLGLGILNNAFRLSPAPSKTLMDNYEMNSGIVTASVTVVWRHPSANSALQSLLLETAHCYL,positive +GGAATGAGTGCCCTGCAAGCGAGGGCTAGC,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,positive +CTCCTCTGACTGTAACCACGCAGCCACCAGGAAGATGAATGCTCGAGCAACTCGACGGTCGGCATAGGTAGTCCAGAAGCC,MLDLFADAEPWQEPLAAGAVILRRFAFNAAEQLIRDINDVASQSPFRQMVTPGGYTMSVAMTNCGHLGWTTHRQGYLYSPIDPQTNKPWPAMPQSFHNLCQRAATAAGYPDFQPDACLINRYAPGAKLSLHQDKDEPDLRAPIVSVSLGLPAIFQFGGLKRNDPLKRLLLEHGDVVVWGGESRLFYHGIQPLKAGFHPLTIDCRYNLTFRQAGKKE,positive +TCCCTACGGCGCTAACTTCTGCAAGAGGCCGTCAACGGGCGAGTTAGCCACCGTGCTACAAC,VENLMVQELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFSHFRLFDENNDAAILILLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVN,positive +CCTAGTGTGCGTCGATGGGGTGGGGTGGGGCTGAGTTGGGGGGTGGGATCAATCAATCTGGTTT,QELLCAASLISDRWVLTAAHCLLYPPWDKNFTVNDILVRIGKYARSRYERNMEKISTLEKIIIHPGYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDKQIVTSLLQAGHKGRVTGWGNLKEMWTVNMNEVQPSVLQMVNLPLVERPICKASTGIRVTDNMFCAGYKPEEGKRGDACEGDSGGPFVMKNPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIRKMVDRFG,positive +CAAUCCAUUCAUCUCUCGAAUGAGGAAGUAGCCCAAGAGGAGGAGGAGGAUGAGC,MVKSHIGSWILVLFVAMWSDVGLCKKRPKPGGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGTHGQWNKPSKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGSDYEDRYYRENMHRYPNQVYYRPVDQYSNQNNFVHDCVNITVKEHTVTTTTKGENFTETDIKMMERVVEQMCITQYQRESQAYYQRGASVILFSSPPVILLISFLIFLIVG,positive +AGUUUCAUCGUCCGAGCAAGAUCCUAAUGGCGUCCGGCGCGUUUAUGACU,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,positive +UUGUUACACACCCGCUUGAAAAAGCAAGUCUGACAA,MSAPASTTQATGSTTSTTTKTAGATPATASGLFTIPDGDFFSTARAVVASDAVATNEDLSEIEAVWKDMKVPTDTMAQAAWDLVRHCADVGSSAQTEMIDTGPYSNGISRARLAAAIKEVCTLRQFCMKYAPVVWNWMLTNNSPPANWQAQGFKPEHKFAAFDFFNGVTNPAAIMPKEGLIRPPSEAEMNAAQTAAFVKITKARAQSNDFASLDAAVTRGRITGTTTAEAVVTLPPP,positive +TCCCACGCATTCTCCACATCATTTGAATAGTGTGGTCACTTCCAGTCCCGCAGGGCACACCCTTTCTGTCCTTCCGTCAC,MSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA,positive +UGAUGGUAUUGGAGCCACCUAAAGGGACGUUUUCGG,MSAPASTTQATGSTTSTTTKTAGATPATASGLFTIPDGDFFSTARAVVASDAVATNEDLSEIEAVWKDMKVPTDTMAQAAWDLVRHCADVGSSAQTEMIDTGPYSNGISRARLAAAIKEVCTLRQFCMKYAPVVWNWMLTNNSPPANWQAQGFKPEHKFAAFDFFNGVTNPAAIMPKEGLIRPPSEAEMNAAQTAAFVKITKARAQSNDFASLDAAVTRGRITGTTTAEAVVTLPPP,positive +GGGAGAGCGAAGCGUGCUGGGCUGCUAUUUUGGCGUAAGCUGGUUUUUGGUGGUUGCGUUUUGAUCAUAACCCAGAGGUCGAUGGAUCC,MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM,positive +GGGAGAAGGGAAGTAACAGGCUAGAAGUUUAGACCAAGGGGCGGGAUGAGTGAGAAGAGGTGACGGTACCAG,QELLCAASLISDRWVLTAAHCLLYPPWDKNFTVNDILVRIGKYARSRYERNMEKISTLEKIIIHPGYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDKQIVTSLLQAGHKGRVTGWGNLKEMWTVNMNEVQPSVLQMVNLPLVERPICKASTGIRVTDNMFCAGYKPEEGKRGDACEGDSGGPFVMKNPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIRKMVDRFG,positive +GAAGTAGCATGAACATATACCCGTTGACTCAATTTTATTTTAGTCCAACA,MAITKINDCFELLSMVTYADKLKSLIKKEFSISFEEFAVLTYISENKEKEYYLKDIINHLNYKQPQVVKAVKILSQEDYFDKKRNEHDERTVLILVNAQQRKKIESLLSRVNKRITEANNEIEL,positive +AGTAATACGACTCACTATAGGGAGAATTCCGACCAGAAGGGUUAGCGGUCGUCUUAAGUAGUUUUUGGUCCTTTCCTCTCTCCTTCCTCTTCT,MSPQRDRINAFYKDNPHPKGSRIVINREHLMIDRPYVLLAVLFVMFLSLIGLLAIAGIRLHRAAIYTAEIHKSLSTNLDVTNSIEHQVKDVLTPLFKIIGDEVGLRTPQRFTDLVKFISDKIKFLNPDREYDFRDLTWCINPPERIKLDYDQYCADVAAEELMNALVNSTLLEARATNQFLAVSKGNCSGPTTIRGQFSNMSLSLLDLYLSRGYNVSSIVTMTSQGMYGGTYLVEKPNLSSKGSELSQLSMHRVFEVGVIRNPGLGAPVFHMTNYFEQPVSNDFSNCMVALGELKFAALCHREDSITIPYQGSGKDVSFQLVKLGVWKSPTDMQSWVPLSTDDPVIDRLYLSSHRGVIADNQAKWAVPTTRTDDKLRMETCFQQACKGKIQALCENPDWAPLKDNRIPSYGVLSVNLSLTVELKIKIASGFGPLITHGSGMDLYKSNHNNMYWLTIPPMKNLALGVINTLEWIPRFRVSPNLFTVPIKEAGEDCHAPTYLPAEVDGDVKLSSNLVILPGQDLQYVLATYDTSRVEHAVVYYVYSPSRSFSYFYPFRLPIKGVPIELQVECFTWDQKLWCRHFCVLADSGSGGHITHSGMVGMGVSCTVTREDGTNRR,positive +UGAGCCGGUCGGCAGUAAUGUGACACUGCGG,IMEIRTVAVGIVAIKGVESEYYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHSGGEMFVALNQKGLPVKGKKTKKEQKTAHFLPMAIT,positive +TTTTTGCTGATCTCGGGTTTGGACTCCTGTTTATTTATAA,MGVHECPAWLWLLLSLLSLPLGLPVLGAPPRLICDSRVLERYLLEAKEAENITTGCAEHCSLNENITVPDTKVNFYAWKRMEVGQQAVEVWQGLALLSEAVLRGQALLVNSSQPWEPLQLHVDKAVSGLRSLTTLLRALGAQKEAISPPDAASAAPLRTITADTFRKLFRVYSNFLRGKLKLYTGEACRTGDR,positive +CAAGAAGUGGAAAUGCGCAGCGACCAUGAAACCUCGCAUGGUUCAUCGAUUGUUUGGAUAGUGUCUGUGUG,MAGRSGDSDEELLKAVRLIKFLYQSNPPPNPEGTRQARRNRRRRWRERQRQIHSISERILSTYLGRSAEPVPLQLPPLERLTLDCNEDCGTSGTQGVGSPQILVESPTILESGAKE,positive +CAGCGGGCATTTCTAGGGCCATCTTTAATCTTCTTTATGGAGAGCCTCGTTCACACGTTG,MRKIVVAAIAVSLTTVSITASASADPSKDSKAQVSAAEAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKVKPSAASIDAAKKAGVNNGNPLDAVQQ,positive +GGUAGAUACGAUGGAGGUGUAUUUUAUGUGCGUAUUUGGAGGCAUGACGCGCAGCCA,MANLGYWLLALFVTMWTDVGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGTWGQPHGGGWGQPHGGSWGQPHGGSWGQPHGGGWGQGGGTHNQWNKPSKPKTNLKHVAGAAAAGAVVGGLGGYMLGSAMSRPMIHFGNDWEDRYYRENMYRYPNQVYYRPVDQYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCVTQYQKESQAYYDGRRSSSTVLFSSPPVILLISFLIFLIVG,positive +AATAGGGGGGGTTCGGTGCAAAGCACCGAACCCCCCC,WPLTEEKIKALVEICXEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEEFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDXIIYQYMDDLYVGSDLEIGQHRTKVEELRQHLLXWGFTTPDKKHQKEPPFLWMGYELHP,positive +UUUCUGUGAUCUUUGCUCGGAAUGGCUGUGGGUAUGGGUGGGUUGGGCUAG,MAAKVASTSSEEAEGSLVTEGEMGEKALPVVYKRYICSFADCGAAYNKNWKLQAHLCKHTGEKPFPCKEEGCEKGFTSLHHLTRHSLTHTGEKNFTCDSDGCDLRFTTKANMKKHFNRFHNIKICVYVCHFENCGKAFKKHNQLKVHQFSHTQQLPYECPHEGCDKRFSLPSRLKRHEKVHAGYPCKKDDSCSFVGKTWTLYLKHVAECHQDLAVCDVCNRKFRHKDYLRDHQKTHEKERTVYLCPRDGCDRSYTTAFNLRSHIQSFHEEQRPFVCEHAGCGKCFAMKKSLERHSVVHDPEKRKLKEKCPRPKRSLASRLTGYIPPKSKEKNASVSGTEKTDSLVKNKPSGTETNGSLVLDKLTIQ,positive +CUCCUCUAGUGAAGGCAGAGAAAGGUCGAUACGGACGGAAUGUGAUGGCC,MSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEMLDRHHTHFCPLEGESWQDFLRNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAFLCQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERETPTTDSMPPLLRQAIELFDHQGAEPAFLFGLELIICGLEKQLKCESGS,positive +CCTGCGTAACAACGCGGAGGAAACTTCCCTCCTATCTCT,MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH,positive +AAGACCACACACACAGAAACAGGGAACAGCGUUCAA,MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICEVEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASSIVYKKEGEQVEFSFPLAFTVEKLTGSGELWWQAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLPQALPQYAGSGNLTLALEAKTGKLHQEVNLVVMRATQLQKNLTCEVWGPTSPKLMLSLKLENKEAKVSKREKAVWVLNPEAGMWQCLLSDSGQVLLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQAERMSQIKRLLSEKKTCQCPHRFQKTCSPI,positive +TCCCACGCATTCTCCACATCTAGTCTGGTTACGGTCTCGATTGTCCCAAAAGGGCAGACACCTTTCTGTCCTTCCGTCAC,MSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA,positive +ACUUCAGCUCUAUUAACAGCUCAAGGACUGGCACA,MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICEVEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASSIVYKKEGEQVEFSFPLAFTVEKLTGSGELWWQAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLPQALPQYAGSGNLTLALEAKTGKLHQEVNLVVMRATQLQKNLTCEVWGPTSPKLMLSLKLENKEAKVSKREKAVWVLNPEAGMWQCLLSDSGQVLLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQAERMSQIKRLLSEKKTCQCPHRFQKTCSPI,positive +GGGCUAGCUGAUCGUACCAGUAGCGUGGCCUGGGGGGCCUAGUCGUGCGAUACUAACAGCUAACACCC,MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA,positive +TCCCTACGGCGCTAACGGATCAAACATGCGCTCCAAGGAGTAGGGGCCACCGTGCTACAAC,VENLMVQELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFSHFRLFDENNDAAILILLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVN,positive +AAGACGGCCGGGGAAACCCGAGGUCCGAUGUAACGC,MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC,positive +AGGCAGAGAAGAGUGGGUGCGACCACAGGAUGUUAUGG,MSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEMLDRHHTHFCPLEGESWQDFLRNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAFLCQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERETPTTDSMPPLLRQAIELFDHQGAEPAFLFGLELIICGLEKQLKCESGS,positive +GACAUCUGUAAGUAAGAUUCUAUCUGCAAAGCGGUUAGGGGGGCUCGGACUCUGAUUGCCUCCCCGCACC,MSGGDGRGHNTGAHSTSGNINGGPTGLGVGGGASDGSGWSSENNPWGGGSGSGIHWGGGSGHGNGGGNGNSGGGSGTGGNLSAVAAPVAFGFPALSTPGAGGLAVSISAGALSAAIADIMAALKGPFKFGLWGVALYGVLPSQIAKDDPNMMSKIVTSLPADDITESPVSSLPLDKATVNVNVRVVDDVKDERQNISVVSGVPMSVPVVDAKPTERPGVFTASIPGAPVLNISVNNSTPAVQTLSPGVTNNTDKDVRPAGFTQGGNTRDAVIRFPKDSGHNAVYVSVSDVLSPDQVKQRQDEENRRQQEWDATHPVEAAERNYERARAELNQANEDVARNQERQAKAVQVYNSRKSELDAANKTLADAIAEIKQFNRFAHDPMAGGHRMWQMAGLKAQRAQTDVNNKQAAFDAAAKEKSDADAALSSAMESRKKKEDKKRSAENNLNDEKNKPRKGFKDYGHDYHPAPKTENIKGLGDLKPGIPKTPKQNGGGKRKRWTGDKGRKIYEWDSQHGELEGYRASDGQHLGSFDPKTGNQLKGPDPKRNIKKYL,positive +CCGTAGGTTCGGGGCGGAGTGGTCCGGAAGGTGGCGTGG,MKPGGNTIVIWMYAVATWLCFGSTSGWSFTLEDNNIFPKQYPIINFTTAGATVQSYTNFIRAVRGRLTTGADVRHEIPVLPNRVGLPINQRFILVELSNHAELSVTLALDVTNAYVVGYRAGNSAYFFHPDNQEDAEAITHLFTDVQNRYTFAFGGNYDRLEQLAGNLRENIELGNGPLEEAISALYYYSTGGTQLPTLARSFIICIQMISEAARFQYIEGEMRTRIRYNRRSAPDPSVITLENSWGRLSTAIQESNQGAFASPIQLQRRNGSKFSVYDVSILIPIIALMVYRCAPPPSSQFSLLIRPVVPNFNADVCMDPEPIVRIVGRNGLCVDVRDGRFHNGNAIQLWPCKSNTDANQLWTLKRDNTIRSNGKCLTTYGYSPGVYVMIYDCNTAATDATRWQIWDNGTIINPRSSLVLAATSGNSGTTLTVQTNIYAVSQGWLPTNNTQPFVTTIVGLYGLCLQANSGQVWIEDCSSEKAEQQWALYADGSIRPQQNRDNCLTSDSNIRETVVKILSCGPASSGQRWMFKNDGTILNLYSGLVLDVRASDPSLKQIILYPLHGDPNQIWLPLF,positive +GGGACACAAUGGACGUCCGUAGAAACGCGUUAAGGUGAAAGUUUGAGGGCUCCUCAUAACGGCCGACAUGAGAG,PHITDVVLDKANKTPLRQLDPSRLPDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFAKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRQSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPINRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDTASEATRPATLNRFSALQQTLPAENTDNRRVVQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRTRTPATKRSFSKEVEERSRERPSQPEGLRKAASLTEDRGRDPVKREATLPPVSPPKAALSVDEVEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRLGIESTLERSTIAREHMGRLLHQLLCAGHLSTAQYYQGLYETLELAEDMEIDIPHVWLYLAELITPILQEDGVPMGELFREITKPLRPMGKATSLLLEILGLLCKSMGPKKVGMLWREAGLSWREFLAEGQDVGSFVAEKKVEYTLGEESEAPGQRTLAFEELRRQLEKLLKDGGSNQRVFDWIDANLNEQQIASNTLVRALMTTVCYSAIIFETPLRVDVQVLKVRARLLQKYLCDEQKELQALYALQALVVTLEQPANLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFNWLREAEDEESDHN,positive +CGAATACCTGGAGGAACACGGGAAAAGATCACTGAAGCCA,RRIKRLEQEKLELSRKLQESTQTVQALQYSTVDGPLTASKDLEIKNLKEEIEKLRKQVTESSHLEQQLEEANAVRQELDDAFRQIKAYEKQIKTLQQEREDLNKELVQASERLKNQSKELKDAHCQRKLAMQEFMEINER,positive +AGAAGAAUGCAGGAAACAGCGAAAUGCGUGUGGC,IMEIRTVAVGIVAIKGVESEYYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHSGGEMFVALNQKGLPVKGKKTKKEQKTAHFLPMAIT,positive +GGATGGGTGGGTGGGGAGGTTGTAGACTGTAT,MLNQLDNLTERVRGSNKLVDRWLHVRKHLLVAYYNLVGIKPGKESYMRLNEKALDDFCQSLVDYLSAGHFSIYERILHKLEGNGQLARAAKIWPQLEANTQQIMDYYDSSLETAIDHDNYLEFQQVLSDIGEALEARFVLEDKLILLVLDAARVKHPA,positive +UCUACCAGAGCGAGUGUGCUGAACGUUCUAAGGACGGGAUUGAAUCGAGAUGCGUAUACUAGGACCUUAGG,MAGRSGDSDEELLKAVRLIKFLYQSNPPPNPEGTRQARRNRRRRWRERQRQIHSISERILSTYLGRSAEPVPLQLPPLERLTLDCNEDCGTSGTQGVGSPQILVESPTILESGAKE,positive +UAAUACGACUCACUAUAGGGAGGACGAUGCGGAAUUGAGGGACCACGCGCUGCUUGUUGUGAUAAGCAGUUUGUCGUGAUGGUCGGGCGAGUCGUCUG,VVIRSNNFTDNAKTIIVQLNESIAINCTRPNNNTRKSIHIGPGRAFYTTGDIIGNIRQAHCNLSRTKWENTLKQIAKKLREQFGNKTIVFNH,positive +AUCCCUGAACCGGCCCAGCAGACUACUGACGGCACGAU,MGVLLTQRTLLSLVLALLFPSMASMAAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQGLDVPKLREHCRERPGAFPSEETLRGLGRRGFLQTLNATLGCVLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILGLRNNIYCMAQLLDNSDTAEPTKAGRGASQPPTPTPASDAFQRKLEGCRFLHGYHRFMHSVGRVFSKWGESPNRSRRHSPHQALRKGVRRTRPSRKGKRLMTRGQLPR,positive +CCUCUUGCACCGCCGAGAAUAUAAUUCAAGAGGUCCACAACUAAUUAG,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,positive +AAUAACUC,PGGVQVSLLKEYYEDGYHIVRDIDSTVGVSISDASLPPRTWNGFLAPKTYKNVYIDTYHNQVFDDIFRTFTIDQHVKLACSLPHGRLRGADKPLIVKEWSGAMTDCAMYLNGRGIGSRFDGSFPSGKPSGACGARSKGSSSELSAQQKKDTLRYIEAQLDAFEVGAGWYFWTW,positive +AGCCGCGAGGGGAGGGAUAGGGUAGGGCGCGGCU,MELAAWCRWGFLLALLPPGIAGTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYVPANASLSFLQDIQEVQGYMLIAHNQVKRVPLQRLRIVRGTQLFEDKYALAVLDNRDPQDNVAASTPGRTPEGLRELQLRSLTEILKGGVLIRGNPQLCYQDMVLWKDVFRKNNQLAPVDIDTNRSRACPPCAPACKDNHCWGESPEDCQILTGTICTSGCARCKGRLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMHNPEGRYTFGASCVTTCPYNYLSTEVGSCTLVCPPNNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLRGARAITSDNVQEFDGCKKIFGSLAFLPESFDGDPSSGIAPLRPEQLQVFETLEEITGYLYISAWPDSLRDLSVFQNLRIIRGRILHDGAYSLTLQGLGIHSLGLRSLRELGSGLALIHRNAHLCFVHTVPWDQLFRNPHQALLHSGNRPEEDLCVSSGLVCNSLCAHGHCWGPGPTQCVNCSHFLRGQECVEECRVWKGLPREYVSDKRCLPCHPECQPQNSSETCFGSEADQCAACAHYKDSSSCVARCPSGVKPDLSYMPIWKYPDEEGICQPCPINCTHSCVDLDERGCPAEQRASPVTFIIATVVGVLLFLILVVVVGILIKRRRQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVREHRGRLGSQDLLNWCVQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPSSPMDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFSPDPTPGTGSTAHRRHRSSSTRSGGGELTLGLEPSEEGPPRSPLAPSEGAGSDVFDGDLAMGVTKGLQSLSPHDLSPLQRYSEDPTLPLPPETDGYVAPLACSPQPEYVNQSEVQPQPPLTPEGPLPPVRPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLVPREGTASPPHPSPAFSPAFDNLYYWDQNSSEQGPPPSNFEGTPTAENPEYLGLDVPV,positive +CGGAATTCCGAGCGTGGGCGTGGTCATACCGCGCCTATCGAACTCGCCACTCGCGTGCAGCTCTGTGTAGGTACGCCCACGCTCGAG,DHNPPTIELIQRFCSDVDMWLKEDSSNVVAVHCKAGKGRTGTMICAYLVFSGIKKSADEALAWYDEKRTKDRKGVTIPSQRRYVQYFSKLVCSSVPYSKVSLNVCEIRFSESSCVQNLGMVECSISVLHDSATENAKPDRLKTLPIDFQKSFVLTIKPSIPVSGDVKFELTKKSPDKIICHFWLNTFFVRNYSPCESDGTVNKYIHTLSKSEIDDVHKDSEHKRFSEEFKISIVFEAENFSNDVQAEASEKERNENVLNFERSDYDSLSPNCYAEKKVLTAIVNDNTTKSQTIETLDHKDIVTKIQYDTSTNSKNTSTACKRKQPNSKTLLPSLNDSTKEEIKRNHIFNQPSIKKTDLIKWQNSEVHITRSINENKNINYNSYITCKQSSPKFNCGTEDGEEDWESGESTYL,positive +NGACUGAUUUUUCCUUGNCAGUGUAAUUUCCUGGCUGCCC,IMEIRTVAVGIVAIKGVESEYYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHSGGEMFVALNQKGLPVKGKKTKKEQKTAHFLPMAIT,positive +AAGACCACACAUAAGAAACAGGGAACAGCGUUCAA,MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICEVEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASSIVYKKEGEQVEFSFPLAFTVEKLTGSGELWWQAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLPQALPQYAGSGNLTLALEAKTGKLHQEVNLVVMRATQLQKNLTCEVWGPTSPKLMLSLKLENKEAKVSKREKAVWVLNPEAGMWQCLLSDSGQVLLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQAERMSQIKRLLSEKKTCQCPHRFQKTCSPI,positive +ACGAAGCUUGAUCCCGUUUGCCGGUCGAUCGCUUCGA,MEPVDPRLEPWKHPGSQPKTACTNCYCKKCCFHCQVCFITKALGISYGRKKRRQRRRAHQNSQTHQASLSKQPTSQPRGDPTGPKE,positive +ACACTCTTTTGCTCGTGTTTTTGCCTGTTACATAAAATGAATCAGTGGATGTTTCCTTCT,MKKTLIALAIAASAASGMAHAWMTGDFNGSVDIGGSITADDYRQKWEWKVGTGLNGFGNVLNDLTNGGTKLTITVTGNKPILLGRTKEAFATPVTGGVDGIPHIAFTDYEGASVVLRNPDGETNKKGLAYFVLPMKNAEGTKVGSVKVNASYAGVLGRGGVTSADGELLSLFADGLSSIFYGGLPRGSELSAGSAAAARTKLFGSLSRNDILGQIQRVNANITSLVDVAGSYRENMEYTDGTVVSAAYALGIANGQTIEATFNQAVTTSTQWSAPLNVAITYY,positive +TGCAGTGCCGAAATAAAGTGTAAAAGCAGTATAAGAAGAC,MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQRGLKNVFDEAILAALEPPETQPKRKCCIF,positive +GUUCCAGGCGCGUUAGCAAAACCGCGGAUC,MASDSIFESFPSYPQCFMRECILGMNPSRDVHDASTSRRFTPPSTALSPGKMSEALPLGAPDAGAALAGKLRSGDRSMVEVLADHPGELARTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFNPQPQSQMQDTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLSTAPSFLFLSNKMLTCKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK,positive +CTCCTCTGACTGTAACCACGCAGCACCAGGAAGATGAATGCTCGAGCAACTCGACGGTCGGCATAGGTAGTCCAGAAGCC,MLDLFADAEPWQEPLAAGAVILRRFAFNAAEQLIRDINDVASQSPFRQMVTPGGYTMSVAMTNCGHLGWTTHRQGYLYSPIDPQTNKPWPAMPQSFHNLCQRAATAAGYPDFQPDACLINRYAPGAKLSLHQDKDEPDLRAPIVSVSLGLPAIFQFGGLKRNDPLKRLLLEHGDVVVWGGESRLFYHGIQPLKAGFHPLTIDCRYNLTFRQAGKKE,positive +AAGCTCTTAGTTGATGCGCGGTCAAAATTTAAGCT,PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGKISKIGPENPYNTPVFAIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDESFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPXRXKNPEMVIYQYMDDLYVGSDLEIGQHRAKIEELRSHLLSWGFTTPDKKHQKEPPFLWMGYELHPDSWTVQPIELPEKDSWTVNE,positive +AGAAAAAAACAAUCCACAGAACAGCGCGUG,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,positive +CCCCCCUCCAAAGACCCGCCAUAUCGCCCC,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,positive +CTCCTCTGACTGTAACCACGCCCATATCGGTGAATGCACGAGCAACCGATTGACACGGGGCATAGGTAGTCCAGAAGCC,MLDLFADAEPWQEPLAAGAVILRRFAFNAAEQLIRDINDVASQSPFRQMVTPGGYTMSVAMTNCGHLGWTTHRQGYLYSPIDPQTNKPWPAMPQSFHNLCQRAATAAGYPDFQPDACLINRYAPGAKLSLHQDKDEPDLRAPIVSVSLGLPAIFQFGGLKRNDPLKRLLLEHGDVVVWGGESRLFYHGIQPLKAGFHPLTIDCRYNLTFRQAGKKE,positive +GGGAGGACGATGCGGCATGCGTCTGACCTACGTGCCAAGCATTTGTGTAACCCGTCAGACGACTCGCCCGA,MNPSAAVIFCLILLGLSGTQGIPLARTVRCNCIHIDDGPVRMRAIGKLEIIPASLSCPRVEIIATMKKNDEQRCLNPESKTIKNLMKAFSQKRSKRAP,positive +CATCTCGGTCGTGAACTTTACATGCATGAGTATTTTGGTG,MKKRKVLIPLMALSTILVSSTGNLEVIQAEVKQENRLLNESESSSQGLLGYYFSDLNFQAPMVVTSSTTGDLSIPSSELENIPSENQYFQSAIWSGFIKVKKSDEYTFATSADNHVTMWVDDQEVINKASNSNKIRLEKGRLYQIKIQYQRENPTEKGLDFKLYWTDSQNKKEVISSDNLQLPELKQKSSNSRKKRSTSAGPTVPDRDNDGIPDSLEVEGYTVDVKNKRTFLSPWISNIHEKKGLTKYKSSPEKWSTASDPYSDFEKVTGRIDKNVSPEARHPLVAAYPIVHVDMENIILSKNEDQSTQNTDSQTRTISKNTSTSRTHTSEVHGNAEVHASFFDIGGSVSAGFSNSNSSTVAIDHSLSLAGERTWAETMGLNTADTARLNANIRYVNTGTAPIYNVLPTTSLVLGKNQTLATIKAKENQLSQILAPNNYYPSKNLAPIALNAQDDFSSTPITMNYNQFLELEKTKQLRLDTDQVYGNIATYNFENGRVRVDTGSNWSEVLPQIQETTARIIFNGKDLNLVERRIAAVNPSDPLETTKPDMTLKEALKIAFGFNEPNGNLQYQGKDITEFDFNFDQQTSQNIKNQLAELNATNIYTVLDKIKLNAKMNILIRDKRFHYDRNNIAVGADESVVKEAHREVINSSTEGLLLNIDKDIRKILSGYIVEIEDTEGLKEVINDRYDMLNISSLRQDGKTFIDFKKYNDKLPLYISNPNYKVNVYAVTKENTIINPSENGDTSTNGIKKILIFSKKGYEIG,positive +ATAACACGACATCCATATGTCAGTGGTCTGTGTACTTACACGGTATTCGA,MKRASAGGSRLLAWVLWLQAWQVAAPCPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDNPWVCDCRARPLWAWLQKFRGSSSEVPCSLPQRLAGRDLKRLAANDLQGCAVATGPYHPIWTGRATDEEPLGLPKCCQPDAADKASVLEPGRPASAGNALKGRVPPGDSPPGNGSGPRHINDSPFGTLPGSAEPPLTAVRPEGSEPPGFPTSGPRRRPGCSRKNRTRSHCRLGQAGSGGGGTGDSEGSGALPSLTCSLTPLGLALVLWTVLGPC,positive +GGGCUAGCUGAUCGUACCCAUAGCGUGGGCAUGGGGUGCCUAGUCGGGCGAUACUAACAGCUAACACCC,MGAARSPPSAVPGPLLGLLLLLLGVLAPGGASLRLLDHRALVCSQPGLNCTVKNSTCLDDSWIHPRNLTPSSPKDLQIQLHFAHTQQGDLFPVAHIEWTLQTDASILYLEGAELSVLQLNTNERLCVRFEFLSKLRHHHRRWRFTFSHFVVDPDQEYEVTVHHLPKPIPDGDPNHQSKNFLVPDCEHARMKVTTPCMSSGSLWDPNITVETLEAHQLRVSFTLWNESTHYQILLTSFPHMENHSCFEHMHHIPAPRPEEFHQRSNVTLTLRNLKGCCRHQVQIQPFFSSCLNDCLRHSATVSCPEMPDTPDGLPAADLIPPPLKPRKVWIIYSADHPLYVDVVLKFAQFLLTACGTEVALDLLEEQAISEAGVMTWVGRQKQEMVESNSKIIVLCSRGTRAKWQALLGRGAPVRLRCDHGKPVGDLFTAAMNMILPDFKRPACFGTYVVCYFSEVSCDGDVPDLFGAAPRYPLMDRFEEVYFRIQDLEMFQPGRMHRVGELSGDNYLRSPGGRQLRAALDRFRDWQVRCPDWFECENLYSADDQDAPSLDEEVFEEPLLPPGTGIVKRAPLVREPGSQACLAIDPLVGEEGGAAVAKLEPHLQPRGQPAPQPLHTLVLAAEEGALVAAVEPGPLADGAAVRLALAGEGEACPLLGSPGAGRNSVLFLPVDPEDSPLGSSTPMASPDLLPEDVREHLEGLMLSLFEQSLSCQAQGGCSRPAMVLTDPHTPYEEEQRQSVQSDQGYISRSSPQPPEGLTEMEEEEEEEQDPGKPALPLSPEDLESLRSLQRQLLFRQLQKNSGWDTMGSESEGPSA,positive +CGCCAGUGUGAAAGAUCCGAAGUUUAUGCCGGCACGCGCUGGCG,MSSTESPVPAAAAPAEAVPASTPAPAAEQPAVGNGEQRNNADAANNTSLYVGELDPSVTEAMLFEIFSMIGTVASIRVCRDAVTRRSLGYAYVNFLNAADGERAMEQLNYSLIRNRPCRIMWSQRDPALRRTGQGNIFIKNLDAGIDNKALHDTFAAFGNILSCKVATNETGSLGYGFVHYETAEAAEAAIKHVNGMLLNDKKVYVGHHIPRKERQAKIEETRANFTNVYAKNVDPEVTDDEFEKLFTKFGKITSCVLQRDEDGKSKGFGFVNFEDHNEAQKAVDELHDSDFKGQKLFVARAQKKSEREEELRRSYEAAKNEKLAKFQGVNLYLKNIPESYDDERLREEFAPFGAITSCKIMRAPSGVSRGFGFVCYSAPEEANKAVSEMNGKMLDNRPLYVALAQRKDVRRQQLEAQIMQRNQLRLQQQAAAQGMGYPGPGMYYPQPGAFPGQPGGMVPRPRYAPAGMMPQGMPMAPYGQPGQFPAGMMPQGYRPARPPRGAPNAAGGPAPPAGARPPTGVNGAPRPAGQPVPGQPMPRGPAARPAGRPEADQPGALTAAALAKASPEEQKQMLGEAIYPKVAASQPELAGKLTGMILELPVTELLHLLEESEALDAKVNEALEVLKEYQQNDSAGAEAEANAEAPKTEA,positive +GGTTGGTGTGGTTGG,ASFTCLAIWALASAGVVPLVLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAAFFFVPVIISTVCYVSIIRCLSSSAVANRSKK,positive +ACCCCTCTTACCCGAAGCGTTAAGCGGTGGAGGCTGTCA,MPEEWVRIFGEAGITQFEQQRNPRLCLSVLNILSKSEHPQEKFMFVPYEQSALPVTDNSPFGDTSITHNYADHHFKASTPENEGSSFYSRVPGPCTVGVRSSSLSSGRGSSEGVGSRSGSGSGGAASRSSSSGHGGAGFPLPVTSVPANGRSSAPGPNSMTVTSGSHSSSGSNCSTGSLTGGMELTNTMVATTQRTGPNNVLVNGHSTGNHFHGGVTQRVAASAAPTECNVLPTYTGSSSSYQPTSFQSMAVHTPPAYTLRQIPPAHSIGYPYTSTAPTSESIILTAPTTTPSSTVYHTTQGSAIVKPLSDNQSQRDKLPYLMHKSQWHSNVTGHVPLSPGLPRRFVDGVLPPETSAHIQYSSGQSSPSPAGSATPVPTPRRESLAGSVPVRAGPAPPALATHELSSDANCTLTPPPVATRPEKTKSIYTKPVEAQCDGHLTIGDQQDASRRSLETPVPPQTAATIHGSENETRTNVTVLPTVHSDGNNSSVHAYQQATESRPLKPNTLERQGQKKVRPKISDEAIQEKLRMIVSIGDPNRKYQRQEKIGQGASGTVYGGIEVATGRRVAIKQMNLKQQPKKELIVNEIYVMKAKKHPNVVNYLDSYLVADELWVVMEYLDGGSLTEVVTETYMEEGQIAAVCRECLQALDFLHKNQVIHRDIKSDNILLGLDGSVKLTDFGFCAQLSSEQNKRSTMVGTPYWMAPEVVTRKQYGPKVDIWSLGIMAIEMLDGEPPYLNENPVRALYLIGTNGKPEIKERDKLSSEFQDFLDLCLEVKVERRATAQELLQHIFSRDGHRAMELLQTDNFHSSGVRKKRTPRLAIEKLVDPEVKRNYQNQLVECLPDGTVSDINGHWEKISKALLKPRRTVVMAAGEDELVVTVRGTSFNCPPTSLVEPNTGIIAPLIEPHHRGIGSYALEVVADIIGTLDYCGIAFLTMGSFVPYLYYSFYCVLWLKLFYLALIFALGSGAIAVSMSNTFASPAYRPLRALVFIALGLSGVIPCVHVTITNGFWPSLQHGSLGWLFLMAVLYITGASIYAVRVPERIFPGRFDIWFQSHQIFHVFVVAAALVHYHGIIGLTNYRLAIGDCRPPPGYPFPKHDYDNIELLRPFMTY,positive +CGAAAGUCUCACUUCCUAAUCCCCUUCUUC,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,positive +TATATATATATATAT,MSARGEEAAGEASGSQEQPEPALAEPKKRGPGRPRKPQQEPTGEPVPKRPRGRPKGSKNKGPSKAAQKKAETTGEKRPRGRPRKWPQQVVQEKPAQEEEEEEEEEEAEED,positive +TTGCACAAGATACGGCTACCTGTATGCGGCAATCGGCATTAAATCTATCTAAGCCAGCAGTAAC,MKRASAGGSRLLAWVLWLQAWQVAAPCPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDNPWVCDCRARPLWAWLQKFRGSSSEVPCSLPQRLAGRDLKRLAANDLQGCAVATGPYHPIWTGRATDEEPLGLPKCCQPDAADKASVLEPGRPASAGNALKGRVPPGDSPPGNGSGPRHINDSPFGTLPGSAEPPLTAVRPEGSEPPGFPTSGPRRRPGCSRKNRTRSHCRLGQAGSGGGGTGDSEGSGALPSLTCSLTPLGLALVLWTVLGPC,positive +GGACCGAGAAGUUACCCUGUAAUCUUAGGAUGAAUCGCAUGCUCUAGCGACCUUUUCGGCUUCGGCGUACGCACAUCGCAGCAAC,MKPSIVAKLEALHERHEEVQALLGDAQTIADQERFRALSREYAQLSDVSRCFTDWQQVQEDIETAQMMLDDPEMREMAQDELREAKEKSEQLEQQLQVLLLPKDPDDERNAFLEVRAGTGGDEAALFAGDLFRMYSRYAEARRWRVEIMSASEGEHGGYKEIIAKISGDGVYGRLKFESGGHRVQRVPATESQGRIHTSACTVAVMPELPDAELPDINPADLRIDTFRSSGAGGQHVNTTDSAIRITHLPTGIVVECQDERSQHKNKAKALSVLGARIHAAEMAKRQQAEASTRRNLLGSGDRSDRNRTYNFPQGRVTDHRINLTLYRLDEVMEGKLDMLIEPIIQEHQADQLAALSEQE,positive +CCCCACCGACCGAUGAUCUUGAGCGUACAUCGCGGG,MSAPASTTQATGSTTSTTTKTAGATPATASGLFTIPDGDFFSTARAVVASDAVATNEDLSEIEAVWKDMKVPTDTMAQAAWDLVRHCADVGSSAQTEMIDTGPYSNGISRARLAAAIKEVCTLRQFCMKYAPVVWNWMLTNNSPPANWQAQGFKPEHKFAAFDFFNGVTNPAAIMPKEGLIRPPSEAEMNAAQTAAFVKITKARAQSNDFASLDAAVTRGRITGTTTAEAVVTLPPP,positive +CACGGUACCACCAAGUCACACGUUGAACUCCAUGCAGCUG,MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYTFLLPEMDNCRSSSSPYVSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQDNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVLVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF,positive +CCTTCATCATTAACCCGTCCACGCGC,MHGDTPTLHEYMLDLQPETTDLYCYEQLNDSSEEEDEIDGPAGQAEPDRAHYNIVTFCCKCDSTLRLCVQSTHVDIRTLEDLLMGTLGIVCPICSQKP,positive +GGGACACAAUGGACGUCCGUAGUUCUGGCUGACUGGUUACCCGGUCGUACAGCUCUAACGGCCGACAUGAGAG,MAGPQALAFGLLLAVVTATLAAAQRDCVCDNYKLATSCSLNEYGECQCTSYGTQNTVICSKLASKCLAMKAEMTHSKSGRRIKPEGAIQNNDGLYDPDCDEQGLFKAKQCNGTATCWCVNTAGVRRTDKDTEITCSERVRTYWIIIELKHKERESPYDHQSLQTALQEAFTSRYKLNQKFIKNIMYENNVITIDLMQNSSQKTQDDVDIADVAYYFEKDVKGESLFHSSKSMDLRVNGEPLDLDPGQTLIYYVDEKAPEFSMQGLTAGIIAVIVVVSLAVIAGIVVLVISTRKKSAKYEKAEIKEMGEIHRELNA,positive +ACCUAGCGCGCUUGACGUGGCCCCUUCGCAGGUCCUGGAU,MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNLERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCPFGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGRVSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVFHKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVEGTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT,positive +GUAUUCUCGGUGGUUUAAUCAGAGUAGAGGAGGCUGACUCCUUUGGUUGGUCUACGUGGAGGUUCUUUUG,MAGRSGDSDEELLKAVRLIKFLYQSNPPPNPEGTRQARRNRRRRWRERQRQIHSISERILSTYLGRSAEPVPLQLPPLERLTLDCNEDCGTSGTQGVGSPQILVESPTILESGAKE,positive +GAGCGGUUAAGGGAGAUUUAGGCAGCAGCUUGGACAGUGUAUCGGCUGAG,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,positive +AGGTTTAGTGAATATCTTCGATGATCCGAGGCAGGCTAGATTCCGAAACATCGTTGAGCG,MRKIVVAAIAVSLTTVSITASASADPSKDSKAQVSAAEAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKVKPSAASIDAAKKAGVNNGNPLDAVQQ,positive +GGGAGACAAGAATAAACGCTCAACAGAGAAGAAGCACCGATGCAACGCGAAAAGCACACGGCCTTCGACAGGAGGCTCACAACAGGC,MPSKKNGRSGPQPHKRWVFTLNNPSEDERKKIRELPISLFDYFIVGEEGNEEGRTPHLQGFANFVKKQTFNKVKWYLGARCHIEKAKGTDQQNKEYCSKEGNLLMECGAPRSQGQRSDLSTAVSTLLESGSLVTVAEQHPVTFVRNFRGLAELLKVSGKMQKRDWKTNVHVIVGPPGCGKSKWAANFADPETTYWKPPRNKWWDGYHGEEVVVIDDFYGWLPWDDLLRLCDRYPLTVETKGGTVPFLARSILITSNQTPLEWYSSAAVPAVEALYRRITSLVFWKNATEQSTEEGGQFVTLSPPCPEFPYEINY,positive +CGTATAGGTCCCCTGCCGCTAAACAGCGCCGCGGTA,PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGKISKIGPENPYNTPVFAIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDESFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPXRXKNPEMVIYQYMDDLYVGSDLEIGQHRAKIEELRSHLLSWGFTTPDKKHQKEPPFLWMGYELHPDSWTVQPIELPEKDSWTVNE,positive +GGUAGAUACGAUGGAUCAGGGUACCCCCUGUGGCCCGUCAACACAGGGGAAGUGGCAUGACGCGCAGCCA,MRQTLPCIYFWGGLLPFGMLCASSTTKCTVSHEVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQALKSEELDIFANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFNPFDCTCESIAWFVNWINETHTNIPELSSHYLCNTPPHYHGFPVRLFDTSSCKDSAPFELFFMINTSILLIFIFIVLLIHFEGWRISFYWNVSVHRVLGFKEIDRQTEQFEYAAYIIHAYKDKDWVWEHFSSMEKEDQSLKFCLEERDFEAGVFELEAIVNSIKRSRKIIFVITHHLLKDPLCKRFKVHHAVQQAIEQNLDSIILVFLEEIPDYKLNHALCLRRGMFKSHCILNWPVQKERIGAFRHKLQVALGSKNSVH,positive +UCAAGAAUUCCGUUUUCAGUCGGGAAAAACUGAACAA,PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGKISKIGPENPYNTPVFAIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDESFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPXRXKNPEMVIYQYMDDLYVGSDLEIGQHRAKIEELRSHLLSWGFTTPDKKHQKEPPFLWMGYELHPDSWTVQPIELPEKDSWTVNE,positive +ACAGCGCCGGUGGGCGGGCAUUGGGUGGAUGCGCUGU,MNQVTIQWDAVIALYILFSWCHGGITNINCSGHIWVEPATIFKMGMNISIYCQAAIKNCQPRKLHFYKNGIKERFQITRINKTTARLWYKNFLEPHASMYCTAECPKHFQETLICGKDISSGYPPDIPDEVTCVIYEYSGNMTCTWNAGKLTYIDTKYVVHVKSLETEEEQQYLTSSYINISTDSLQGGKKYLVWVQAANALGMEESKQLQIHLDDIVIPSAAVISRAETINATVPKTIIYWDSQTTIEKVSCEMRYKATTNQTWNVKEFDTNFTYVQQSEFYLEPNIKYVFQVRCQETGKRYWQPWSSLFFHKTPETVPQVTSKAFQHDTWNSGLTVASISTGHLTSDNRGDIGLLLGMIVFAVMLSILSLIGIFNRSFRTGIKRRILLLIPKWLYEDIPNMKNSNVVKMLQENSELMNNNSSEQVLYVDPMITEIKEIFIPEHKPTDYKKENTGPLETRDYPQNSLFDNTTVVYIPDLNTGYKPQISNFLPEGSHLSNNNEITSLTLKPPVDSLDSGNNPRLQKHPNFAFSVSSVNSLSNTIFLGELSLILNQGECSSPDIQNSVEEETTMLLENDSPSETIPEQTLLPDEFVSCLGIVNEELPSINTYFPQNILESHFNRISLLEK,positive +GGGACGCTGAGGCTTCTATGGTTCCC,DPAFEGPYFQSHNAGRHREAAEGLFAAGRAYYCDCTREQLKERTGSEHLGYDGFCRERGLGYAAGRALRFRTPDEGETVVADLVRGEPAFPNSAIEDFVIARGDGSPVFLLANVVDDLDEGITQVIRGEEHLSNTPKQQLLWEALGAGPPVWAHLPVIVNEKRQKLSKRRDKVALEDYLGEGFLPEALVNYLMLLGWGPGGDREIMPYEELERLFRIEDVNTAPAFFDVKKLTAFNGEYLRALAPAQFAAACVPWLVAPYAPWRPEAFDKDVFEAAAPLARTRLTRLSEITGYVDFLFLDEPVDDEVSWHKAMKEGAADILTDVRAGLAAVTGWTAEELKGVLLAVGEQHGLKLGKAQAPVRVAVTGRTVGLPLFRVPGTGSAGSGCWPGWTPQIRRLAGRGAPG,positive +GGGAGGACGATGCGGACTGAACCTAATTTGAAATTGGCTGGCGCGCATATTCCGTCAGACGACTCGCCCGA,MNQTAILICCLIFLTLSGIQGVPLSRTVRCTCISISNQPVNPRSLEKLEIIPASQFCPRVEIIATMKKKGEKRCLNPESKAIKNLLKAVSKERSKRSP,positive +GCGAGCAUCAGCCGC,MASNFTQFVLVDNGGTGDVTVAPSNFANGVAEWISSNSRSQAYKVTCSVRQSSAQNRKYTIKVEVPKVATQTVGGVELPVAAWRSYLNMELTIPIFATNSDCELIVKAMQGLLKDGNPIPSAIAANSGIY,positive +AGAGUCGCUGAUGGUAGACGCCGGCGGAUC,MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPGPHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR,positive +AGGGAATCTTGCCTAGGGAGGGAGTAGCGAAAGGGCTCA,MPVKMVAVLGASTVLWILFAVSQAFKIEISPEYKTIAQIGDSMALTCSTTGCESPLFSWRTQIDSPLNAKVRTEGSKSVLTMEPVSFENEHSYLCTATCGSGKLERSIHVDIYSFPKDPEIQFSGPLEVGKPVTVKCLAPDIYPVYRLEIDLFKGDQLMNRQEFSSEEMTKSLETKSLEVTFTPVIEDIGKALVCRAKLHIDQIDSTLKERETVKELQVYISPRNTTISVHPSTRLQEGGAVTMTCSSEGLPAPEIFWGRKLDNEVLQLLSGNATLTLIAMRMEDSGVYVCEGVNLIGRDKAEVELVVQEKPFIVDISPGSQVAAQVGDSVVLTCAAIGCDSPSFSWRTQTDSPLNGVVRNEGAKSTLVLSSVGFEDEHSYLCAVTCLQRTLEKRTQVEVYSFPEDPVIKMSGPLVHGRPVTVNCTVPNVYPFDHLEIELLKGETTLMKKYFLEEMGIKSLETKILETTFIPTIEDTGKSLVCLARLHSGEMESEPKQRQSVQPLYVNVAPKETTIWVSPSPILEEGSPVNLTCSSDGIPAPKILWSRQLNNGELQPLSENTTLTFMSTKRDDSGIYVCEGINEAGISRKSVELIIQVSPKDIQLTVFPSKSVKEGDTVIISCTCGNVPETWIILKKKAKTGDMVLKSVDGSYTIRQAQLQDAGIYECESKTEVGSQLRSLTLDVKGKEHNKDYFSPELLALYCASSLVIPAIGMIVYFARKANMKGSYSLVEAQKSKV,positive +AAGGACAGCACGAAUAAAACCUGCGUAAAUCCGCCCCAUUUGUGUAAGGGUAGUGGG,MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINYDEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQAVAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQGIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADMDFSALLSQISS,positive +GCCCGAUCUACUGCAUUACCGAAACGAUUUCCCCACUGU,IMEIRTVAVGIVAIKGVESEYYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHSGGEMFVALNQKGLPVKGKKTKKEQKTAHFLPMAIT,positive +GCAGCAGGGAGAGTTGTGTGAGGGAAGTGGTCGGTAGGTG,MKPGGNTIVIWMYAVATWLCFGSTSGWSFTLEDNNIFPKQYPIINFTTAGATVQSYTNFIRAVRGRLTTGADVRHEIPVLPNRVGLPINQRFILVELSNHAELSVTLALDVTNAYVVGYRAGNSAYFFHPDNQEDAEAITHLFTDVQNRYTFAFGGNYDRLEQLAGNLRENIELGNGPLEEAISALYYYSTGGTQLPTLARSFIICIQMISEAARFQYIEGEMRTRIRYNRRSAPDPSVITLENSWGRLSTAIQESNQGAFASPIQLQRRNGSKFSVYDVSILIPIIALMVYRCAPPPSSQFSLLIRPVVPNFNADVCMDPEPIVRIVGRNGLCVDVRDGRFHNGNAIQLWPCKSNTDANQLWTLKRDNTIRSNGKCLTTYGYSPGVYVMIYDCNTAATDATRWQIWDNGTIINPRSSLVLAATSGNSGTTLTVQTNIYAVSQGWLPTNNTQPFVTTIVGLYGLCLQANSGQVWIEDCSSEKAEQQWALYADGSIRPQQNRDNCLTSDSNIRETVVKILSCGPASSGQRWMFKNDGTILNLYSGLVLDVRASDPSLKQIILYPLHGDPNQIWLPLF,positive +TCCCACGCATTCTCCACATCGATACTGAGCATCGTACATGATCCCGCAACGGGCAGTATTCCTTTCTGTCCTTCCGTCAC,MSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA,positive +ATCCACTACGAACTCCGCATTCCCAGACACACTGGACCT,MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP,positive +ACUCACCAGUCACCAUCAGCUCAUGCGCCCCUCCCCCGAC,MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYTFLLPEMDNCRSSSSPYVSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQDNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVLVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF,positive +GGCGGCCGTGAAATTTGCCAAATGCCGTCTTGGCTTTCGCCCAATGTATCCTGGGTGTTC,MKKTLIALAIAASAASGMAHAWMTGDFNGSVDIGGSITADDYRQKWEWKVGTGLNGFGNVLNDLTNGGTKLTITVTGNKPILLGRTKEAFATPVTGGVDGIPHIAFTDYEGASVVLRNPDGETNKKGLAYFVLPMKNAEGTKVGSVKVNASYAGVLGRGGVTSADGELLSLFADGLSSIFYGGLPRGSELSAGSAAAARTKLFGSLSRNDILGQIQRVNANITSLVDVAGSYRENMEYTDGTVVSAAYALGIANGQTIEATFNQAVTTSTQWSAPLNVAITYY,positive +GCCCUCCAACCACACCCCGCCAACAACCCC,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,positive +AUCUCCCACACUUCAUCGGUUCACCCUACUCCCUUGCAU,MGVLLTQRTLLSLVLALLFPSMASMAAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQGLDVPKLREHCRERPGAFPSEETLRGLGRRGFLQTLNATLGCVLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILGLRNNIYCMAQLLDNSDTAEPTKAGRGASQPPTPTPASDAFQRKLEGCRFLHGYHRFMHSVGRVFSKWGESPNRSRRHSPHQALRKGVRRTRPSRKGKRLMTRGQLPR,positive +UCCCCCGCGCACAUUCCCGCCAACCUGCAA,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,positive +CAGGAUGAACAAGCAGGACGUGAAAUGAAC,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,positive +GGGACACAAUGGACGCACCUCCGACGCACAGUCGCAGGCUCGAAAGAGACUAAAUGCUAACGGCCGACAUGAGAG,PHITDVVLDKANKTPLRQLDPSRLPDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFAKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRQSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPINRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDTASEATRPATLNRFSALQQTLPAENTDNRRVVQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRTRTPATKRSFSKEVEERSRERPSQPEGLRKAASLTEDRGRDPVKREATLPPVSPPKAALSVDEVEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRLGIESTLERSTIAREHMGRLLHQLLCAGHLSTAQYYQGLYETLELAEDMEIDIPHVWLYLAELITPILQEDGVPMGELFREITKPLRPMGKATSLLLEILGLLCKSMGPKKVGMLWREAGLSWREFLAEGQDVGSFVAEKKVEYTLGEESEAPGQRTLAFEELRRQLEKLLKDGGSNQRVFDWIDANLNEQQIASNTLVRALMTTVCYSAIIFETPLRVDVQVLKVRARLLQKYLCDEQKELQALYALQALVVTLEQPANLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFNWLREAEDEESDHN,positive +AGCTTAGTGCATATCACTCCTCGTTATAGCATGGTTATAG,MKKRKVLIPLMALSTILVSSTGNLEVIQAEVKQENRLLNESESSSQGLLGYYFSDLNFQAPMVVTSSTTGDLSIPSSELENIPSENQYFQSAIWSGFIKVKKSDEYTFATSADNHVTMWVDDQEVINKASNSNKIRLEKGRLYQIKIQYQRENPTEKGLDFKLYWTDSQNKKEVISSDNLQLPELKQKSSNSRKKRSTSAGPTVPDRDNDGIPDSLEVEGYTVDVKNKRTFLSPWISNIHEKKGLTKYKSSPEKWSTASDPYSDFEKVTGRIDKNVSPEARHPLVAAYPIVHVDMENIILSKNEDQSTQNTDSQTRTISKNTSTSRTHTSEVHGNAEVHASFFDIGGSVSAGFSNSNSSTVAIDHSLSLAGERTWAETMGLNTADTARLNANIRYVNTGTAPIYNVLPTTSLVLGKNQTLATIKAKENQLSQILAPNNYYPSKNLAPIALNAQDDFSSTPITMNYNQFLELEKTKQLRLDTDQVYGNIATYNFENGRVRVDTGSNWSEVLPQIQETTARIIFNGKDLNLVERRIAAVNPSDPLETTKPDMTLKEALKIAFGFNEPNGNLQYQGKDITEFDFNFDQQTSQNIKNQLAELNATNIYTVLDKIKLNAKMNILIRDKRFHYDRNNIAVGADESVVKEAHREVINSSTEGLLLNIDKDIRKILSGYIVEIEDTEGLKEVINDRYDMLNISSLRQDGKTFIDFKKYNDKLPLYISNPNYKVNVYAVTKENTIINPSENGDTSTNGIKKILIFSKKGYEIG,positive +GGGAAUAAUAAUAAUAAAG,GRQVDIDGEDYQRRDSIAQLLEDWGLIVIEDSAREDLFGLTNNFRVISFKQKDDWTLKAKYTIGN,positive +GCCAGCATCCCGACTGGGCTCCTCGATAACGAGTGCCCG,MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA,positive +AGCGCGGGAUGUUAUGGCACGAUGUGUAGAGAAUAGCGCUGAUCGGGCAA,MSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEMLDRHHTHFCPLEGESWQDFLRNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAFLCQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERETPTTDSMPPLLRQAIELFDHQGAEPAFLFGLELIICGLEKQLKCESGS,positive +AUCAGUCCCCACUGCCCCCGCUUGCAGACA,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,positive +ATACCAGTCTATTCAATTGCACTCTGTGGGGGTGGACGGGCCGGGTAGATAGTATGTGCAATC,MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPGPHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR,positive +GGTTGGTCTGGTTGG,ASFTCLAIWALASAGVVPLVLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAAFFFVPVIISTVCYVSIIRCLSSSAVANRSKK,positive +GAUCCUUUGUGGGCUCUUGUUGACCCCCUCGUUGUCCCCCC,IMEIRTVAVGIVAIKGVESEYYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHSGGEMFVALNQKGLPVKGKKTKKEQKTAHFLPMAIT,positive +TAATACGACTCACTATAGGGAAGAGGTCAGATGGTCTAGCCGGAGGAGTCAGTAATCGGTAGACCTATGCGTGCTAGAGTGA,MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA,positive +AATACGTGCTCCCTCCGCCAAAGGCGGAGGGAGCACG,WPLTEEKIKALVEICXEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEEFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDXIIYQYMDDLYVGSDLEIGQHRTKVEELRQHLLXWGFTTPDKKHQKEPPFLWMGYELHP,positive +CATGCGCCTTCCCCCTGTGGTTGGTGTCAGCCGGCCTGTG,SESGFNLSCQCLGFGSGHFKCDSSKWCHDNGVNYKIGEKWDRQGENGQMMSCTCLGNGKGEF,positive +CCTTCGTTGTCTGCCTTCGTCGATCGGCATTACGCCATTGGTTGGTGTGGTTGCGATTATGCGCTAATTCACCCTTCAGAATTCGCACCA,MKQYLNTVISNPRPAQALGINQPFVVFCFITSRALSFVPAIYWCFKCLHLAFVADKFKWLPLTSALWTLVSAYLSFVLANGFLLKWLIHYSIGPTIIRLFSLNVINFSFLSLSVSFITHGDNAYLLPAWIAISCFQTAAYIVQDWITSPIIRTLPFRSSSSSSSNYRHNLDFLEITVFAVVPVGIASFFTMVMLIWQLYKYPDSFLVSA,positive +CTTCTGCCCGCCTCCTTCCGGAATGATGCGTAAAGGACCGAGGGTGCTTGCCATAATCGGAGACGAGATAGGCGGACACT,MEGMLKGEGPGPLPPLLQQYVELRDQYPDYLLLFQVGDFYECFGEDAERLARALGLVLTHKTSKDFTTPMAGIPLRAFEAYAERLLKMGFRLAVADQVEPAEEAEGLVRREVTQLLTPGTLLQESLLPREANYLAAIATGDGWGLAFLDVSTGEFKGTVLKSKSALYDELFRHRPAEVLLAPELLENGAFLDEFRKRFPVMLSEAPFEPEGEGPLALRRARGALLAYAQRTQGGALSLQPFRFYDPGAFMRLPEATLRALEVFEPLRGQDTLFSVLDETRTAPGRRLLQSWLRHPLLDRGPLEARLDRVEGFVREGALREGVRRLLYRLADLERLATRLELGRASPKDLGALRRSLQILPELRALLGEEVGLPDLSPLKEELEAALVEDPPLKVSEGGLIREGYDPDLDALRAAHREGVAYFLELEERERERTGIPTLKVGYNAVFGYYLEVTRPYYERVPKEYRPVQTLKDRQRYTLPEMKEKEREVYRLEALIRRREEEVFLEVRERAKRQAEALREAARILAELDVYAALAEVAVRYGYVRPRFGDRLQIRAGRHPVVERRTEFVPNDLEMAHELVLITGPNMAGKSTFLRQTALIALLAQVGSFVPAEEAHLPLFDGIYTRIGASDDLAGGKSTFMVEMEEVALILKEATENSLVLLDEVGRGTSSLDGVAIATAVAEALHERRAYTLFATHYFELTALGLPRLKNLHVAAREEAGGLVFYHQVLPGPASKSYGVEVAAMAGLPKEVVARARALLQAMAARREGALDAVLERLLALDPDRLTPLEALRLLQELKALALGAPLDTMKG,positive +TTGGGGTGGGAGGGCGGGTTAACAAAGATAGCGCAACAGG,MSMSPKHTTPFSVSDILSPLEESYKKVGMEGGGLGAPLAAYRQGQAAPPAAAMQQHAVGHHGAVTAAYHMTAAGVPQLSHSAVGGYCNGNLGNMSELPPYQDTMRNSASGPGWYGANPDPRFPAISRFMGPASGMNMSGMGGLGSLGDVSKNMAPLPSAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGGGGGGGAGCPQQQQAQQQSPRRVAVPVLVKDGKPCQAGAPAPGAGSLQGHAQQQAQQQAQAAQAAAAAISVGSGGPGLGAHPGHQPGSAGQSPDLAHHAASPAALQGQVSSLSHLNSSGSDYGTMSCSTLLYGRTW,positive +GGGGCCACCAACGACAUUGAACCACGUAGGCUCGUUUCUGAGCCGAUCUCGAUGUUGAUAUAAAUAGUGCCCAUGGAUC,MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP,positive +ACGUGCUCUCAUCUUUUAAUUCGUGGGCUCUGCGGCUAGCCUCUUAGCUC,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,positive +AGGCAGAGAAAGGUCGAUACGGACGGAAUGUGAUGGCC,MSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEMLDRHHTHFCPLEGESWQDFLRNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAFLCQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERETPTTDSMPPLLRQAIELFDHQGAEPAFLFGLELIICGLEKQLKCESGS,positive +AATTTCTACTGCAATTTCTACTGC,MDHLNEATQGKEHSEMSNNVSDPKGPPAKIARLEQNGSPLGRGRLGSTGAKMQGVPLKHSGHLMKTNLRKGTMLPVFCVVEHYENAIEYDCKEEHAEFVLVRKDMLFNQLIEMALLSLGYSHSSAAQAKGLIQVGKWNPVPLSYVTDAPDATVADMLQDVYHVVTLKIQLHSCPKLEDLPPEQWSHTTVRNALKDLLKDMNQSSLAKECPLSQSMISSIVNSTYYANVSAAKCQEFGRWYKHFKKTKDMMVEMDSLSELSQQGANHVNFGQQPVPGNTAEQPPSPAQLSHGSQPSVRTPLPNLHPGLVSTPISPQLVNQQLVMAQLLNQQYAVNRLLAQQSLNQQYLNHPPPVSRSMNKPLEQQVSTNTEVSSEIYQWVRDELKRAGISQAVFARVAFNRTQGLLSEILRKEEDPKTASQSLLVNLRAMQNFLQLPEAERDRIYQDERERSLNAASAMGPAPLISTPPSRPPQVKTATIATERNGKPENNTMNINASIYDEIQQEMKRAKVSQALFAKVAATKSQGWLCELLRWKEDPSPENRTLWENLSMIRRFLSLPQPERDAIYEQESNAVHHHGDRPPHIIHVPAEQIQQQQQQQQQQQQQQQAPPPPQPQQQPQTGPRLPPRQPTVASPAESDEENRQKTRPRTKISVEALGILQSFIQDVGLYPDEEAIQTLSAQLDLPKYTIIKFFQNQRYYLKHHGKLKDNSGLEVDVAEYKEEELLKDLEESVQDKNTNTLFSVKLEEELSVEGNTDINTDLKD,positive +CAGACCGTAAGGGATGCCGCCTAAACACC,MKKRKVLIPLMALSTILVSSTGNLEVIQAEVKQENRLLNESESSSQGLLGYYFSDLNFQAPMVVTSSTTGDLSIPSSELENIPSENQYFQSAIWSGFIKVKKSDEYTFATSADNHVTMWVDDQEVINKASNSNKIRLEKGRLYQIKIQYQRENPTEKGLDFKLYWTDSQNKKEVISSDNLQLPELKQKSSNSRKKRSTSAGPTVPDRDNDGIPDSLEVEGYTVDVKNKRTFLSPWISNIHEKKGLTKYKSSPEKWSTASDPYSDFEKVTGRIDKNVSPEARHPLVAAYPIVHVDMENIILSKNEDQSTQNTDSQTRTISKNTSTSRTHTSEVHGNAEVHASFFDIGGSVSAGFSNSNSSTVAIDHSLSLAGERTWAETMGLNTADTARLNANIRYVNTGTAPIYNVLPTTSLVLGKNQTLATIKAKENQLSQILAPNNYYPSKNLAPIALNAQDDFSSTPITMNYNQFLELEKTKQLRLDTDQVYGNIATYNFENGRVRVDTGSNWSEVLPQIQETTARIIFNGKDLNLVERRIAAVNPSDPLETTKPDMTLKEALKIAFGFNEPNGNLQYQGKDITEFDFNFDQQTSQNIKNQLAELNATNIYTVLDKIKLNAKMNILIRDKRFHYDRNNIAVGADESVVKEAHREVINSSTEGLLLNIDKDIRKILSGYIVEIEDTEGLKEVINDRYDMLNISSLRQDGKTFIDFKKYNDKLPLYISNPNYKVNVYAVTKENTIINPSENGDTSTNGIKKILIFSKKGYEIG,positive +CAGUCGUCAUGGUUAUAGCUGCCACAACCUCGGUCCUGUCUUCAACGGCC,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,positive +GAAGCUUACAAGAAGGACAGCACGAAUAAAACCUGCGUAAAUCCGCCCCAUUUGUGUAAGGGUAGUAAAUCGAAUUCCGCUCA,MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINYDEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQAVAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQGIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADMDFSALLSQISS,positive +GGAGCGCAAUUCGCCUCGCAAGUUGAACUCCGCUGGCGG,MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYTFLLPEMDNCRSSSSPYVSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQDNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVLVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF,positive +TATCAACTAACGTACTGCCGCATTCCCACAATCCACAGGCTCC,MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP,positive +ATTGACCGCTGTGTGACGCAACACTCAAT,MRKIVVAAIAVSLTTVSITASASADPSKDSKAQVSAAEAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKVKPSAASIDAAKKAGVNNGNPLDAVQQ,positive +GGCTGTTGTGAGCCTCCTCCCAGAGGGAAGACTTTAGGTTCGGTTCACGTCCCGCTTATTCTTACTCCC,EFPPSTFYRVTLYGLYKGELLDPVFAEAITEAEPEVEHITVSDITPHSFKVTWTAPEAVFDSFALKVLDSSGLGRPHQISVSGDKRTEAVTGLNEDTDYEIELFGIILGRKFQPIFTVARTGLGTRKGIRFSDVTDTSATVHWTMPHTRVDNYRVIYVPIQGGSPLTLRVDGGESQAMLSNLTPGVTYQVTVIAVKGLEESEPGSERVTTALDKPRGLTAVNISDTEALLLWQPSIATVDGYVITYSADSVAPVMERVSGNTVEFEMSSLTPATLYTVKVYAFRDTAKSAATSTDFTTDVDAPQNLAASNIQTETAMLTWKPPRADISGYILSFESADGVVKEVVLSPTATFYSMSHLTASTEYTVKLQAIAGPKRSRVISTVFLTIGVLYKHPKDCSQALLNGDTTSGFYTIYLRGDESQPLQVYCDMTTDGGGWIVFVRRQSGKVEFFRNWKNYTAGFGDLNDEFWLGLSNLHKITSFGQYELRVDLRDKGESAYAQYDKFSISEPRARYKVHVGGYSGTAGDSMTYHHGRPFSTYDNDNDIAVTNCALSYKGAFWYKNCHRVNIMGRYGDNSHSKGVNWFHWKGHEHSVEFAEMKIRPANFRNFEGRKKRS,positive +GUAUUCUCGGUGGUUUAAUCAGAGUAGAGGAGGCUGACUCCUUUGGUUGGUCUACGUGGAGGUUCCUUUG,MAGRSGDSDEELLKAVRLIKFLYQSNPPPNPEGTRQARRNRRRRWRERQRQIHSISERILSTYLGRSAEPVPLQLPPLERLTLDCNEDCGTSGTQGVGSPQILVESPTILESGAKE,positive +GCAATGGTACGGTACTTCCTGTGGCGAGGTAGGTGGGGTGTGTGTGTATCCAAAAGTGCACGCTACTTTGCTAA,MSKSESPKEPEQLRKLFIGGLSFETTDESLRSHFEQWGTLTDCVVMRDPNTKRSRGFGFVTYATVEEVDAAMNARPHKVDGRVVEPKRAVSREDSQRPGAHLTVKKIFVGGIKEDTEEHHLRDYFEQYGKIEVIEIMTDRGSGKKRGFAFVTFDDHDSVDKIVIQKYHTVNGHNCEVRKALSKQEMASASSSQRGRSGSGNFGGGRGGGFGGNDNFGRGGNFSGRGGFGGSRGGGGYGGSGDGYNGFGNDGGYGGGGPGYSGGSRGYGSGGQGYGNQGSGYGGSGSYDSYNNGGGGGFGGGSGSNFGGGGSYNDFGNYNNQSSNFGPMKGGNFGGRSSGPYGGGGQYFAKPRNQGGYGGSSSSSSYGSGRRF,positive +GUAUUCUCGGUGGUUUAAUCAGAGUAGAGGAGGCUGACUCCUUUGGUUGGACUACGUGGAGGUUCUCUU,MAGRSGDSDEELLKAVRLIKFLYQSNPPPNPEGTRQARRNRRRRWRERQRQIHSISERILSTYLGRSAEPVPLQLPPLERLTLDCNEDCGTSGTQGVGSPQILVESPTILESGAKE,positive +AUCGCCCUGAACCGGCCCAGCAGACUGCUGACGGCACGAU,MGVLLTQRTLLSLVLALLFPSMASMAAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQGLDVPKLREHCRERPGAFPSEETLRGLGRRGFLQTLNATLGCVLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILGLRNNIYCMAQLLDNSDTAEPTKAGRGASQPPTPTPASDAFQRKLEGCRFLHGYHRFMHSVGRVFSKWGESPNRSRRHSPHQALRKGVRRTRPSRKGKRLMTRGQLPR,positive +TCTCATGCGCCGAGTGTGAGTTTACCTTCGT,MGLLGILCFLIFLGKTWGQEQTYVISAPKIFRVGASENIVIQVYGYTEAFDATISIKSYPDKKFSYSSGHVHLSSENKFQNSAILTIQPKQLPGGQNPVSYVYLEVVSKHFSKSKRMPITYDNGFLFIHTDKPVYTPDQSVKVRVYSLNDDLKPAKRETVLTFIDPEGSEVDMVEEIDHIGIISFPDFKIPSNPRYGMWTIKAKYKEDFSTTGTAYFEVKEYVLPHFSVSIEPEYNFIGYKNFKNFEITIKARYFYNKVVTEADVYITFGIREDLKDDQKEMMQTAMQNTMLINGIAQVTFDSETAVKELSYYSLEDLNNKYLYIAVTVIESTGGFSEEAEIPGIKYVLSPYKLNLVATPLFLKPGIPYPIKVQVKDSLDQLVGGVPVTLNAQTIDVNQETSDLDPSKSVTRVDDGVASFVLNLPSGVTVLEFNVKTDAPDLPEENQAREGYRAIAYSSLSQSYLYIDWTDNHKALLVGEHLNIIVTPKSPYIDKITHYNYLILSKGKIIHFGTREKFSDASYQSINIPVTQNMVPSSRLLVYYIVTGEQTAELVSDSVWLNIEEKCGNQLQVHLSPDADAYSPGQTVSLNMATGMDSWVALAAVDSAVYGVQRGAKKPLERVFQFLEKSDLGCGAGGGLNNANVFHLAGLTFLTNANADDSQENDEPCKEILRPRRTLQKKIEEIAAKYKHSVVKKCCYDGACVNNDETCEQRAARISLGPRCIKAFTECCVVASQLRANISHKDMQLGRLHMKTLLPVSKPEIRSYFPESWLWEVHLVPRRKQLQFALPDSLTTWEIQGVGISNTGICVADTVKAKVFKDVFLEMNIPYSVVRGEQIQLKGTVYNYRTSGMQFCVKMSAVEGICTSESPVIDHQGTKSSKCVRQKVEGSSSHLVTFTVLPLEIGLHNINFSLETWFGKEILVKTLRVVPEGVKRESYSGVTLDPRGIYGTISRRKEFPYRIPLDLVPKTEIKRILSVKGLLVGEILSAVLSQEGINILTHLPKGSAEAELMSVVPVFYVFHYLETGNHWNIFHSDPLIEKQKLKKKLKEGMLSIMSYRNADYSYSVWKGGSASTWLTAFALRVLGQVNKYVEQNQNSICNSLLWLVENYQLDNGSFKENSQYQPIKLQGTLPVEARENSLYLTAFTVIGIRKAFDICPLVKIDTALIKADNFLLENTLPAQSTFTLAISAYALSLGDKTHPQFRSIVSALKREALVKGNPPIYRFWKDNLQHKDSSVPNTGTARMVETTAYALLTSLNLKDINYVNPVIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVKQLRLSMDIDVSYKHKGALHNYKMTDKNFLGRPVEVLLNDDLIVSTGFGSGLATVHVTTVVHKTSTSEEVCSFYLKIDTQDIEASHYRGYGNSDYKRIVACASYKPSREESSSGSSHAVMDISLPTGISANEEDLKALVEGVDQLFTDYQIKDGHVILQLNSIPSSDFLCVRFRIFELFEVGFLSPATFTVYEYHRPDKQCTMFYSTSNIKIQKVCEGAACKCVEADCGQMQEELDLTISAETRKQTACKPEIAYAYKVSITSITVENVFVKYKATLLDIYKTGEAVAEKDSEITFIKKVTCTNAELVKGRQYLIMGKEALQIKYNFSFRYIYPLDSLTWIEYWPRDTTCSSCQAFLANLDEFAEDIFLNGC,positive +CAGGCGTTAGGGAAGGGCGTCGAAAGCAGGGTGGG,PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGKISKIGPENPYNTPVFAIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDESFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPXRXKNPEMVIYQYMDDLYVGSDLEIGQHRAKIEELRSHLLSWGFTTPDKKHQKEPPFLWMGYELHPDSWTVQPIELPEKDSWTVNE,positive +CCUGUGUCUUGUGUGUGUGUUUUGUUUCUGGUCUA,MAWYWWRRRRRRGWWKPRRRRWRRRRARRRGPARRHRARRRIVRHPCNGQTSSGNRVPRSVQAVDPKYVSLQLVWHSWDFRRGLFGQAGIKRMQQESDALTLSPVHRPKRPKRDTQVKEKTPEKDSDSAVQLRRLQPWIHSSQETKDEEEEIPEGPVQEQLLQQLQQQRLLRVQLESIAQEVLKIRRGHSLHPLLSSHA,positive +TTGGGGAGGGGCACTGGGCAGTGTAATTTACGAAAGCGAG,MEKVQYLTRSAIRRASTIEMPQQARQKLQNLFINFCLILICLLLICIIVMLL,positive +GAAUCAUACACAAGUUGUGGAG,MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC,positive +GGGAGAGCGGAAGCGUGCUGGGCCUGUCGUUCGCUGUCUUGCUACGUUACGUUACACGGUUGGCAUAACCCAGAGGUCGAUGGAUCCCCCC,MSDNGPQSNQRSAPRITFGGPTDSTDNNQNGGRNGARPKQRRPQGLPNNTASWFTALTQHGKEELRFPRGQGVPINTNSGPDDQIGYYRRATRRVRGGDGKMKELSPRWYFYYLGTGPEASLPYGANKEGIVWVATEGALNTPKDHIGTRNPNNNAATVLQLPQGTTLPKGFYAEGSRGGSQASSRSSSRSRGNSRNSTPGSSRGNSPARMASGGGETALALLLLDRLNQLESKVSGKGQQQQGQTVTKKSAAEASKKPRQKRTATKQYNVTQAFGRRGPEQTQGNFGDQDLIRQGTDYKHWPQIAQFAPSASAFFGMSRIGMEVTPSGTWLTYHGAIKLDDKDPQFKDNVILLNKHIDAYKTFPPTEPKKDKKKKTDEAQPLPQRQKKQPTVTLLPAADMDDFSRQLQNSMSGASADSTQA,positive +GGTTGGTTTATTTTATTACTAGTGGCCAGG,QELLCAASLISDRWVLTAAHCLLYPPWDKNFTVNDILVRIGKYARSRYERNMEKISTLEKIIIHPGYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDKQIVTSLLQAGHKGRVTGWGNLKEMWTVNMNEVQPSVLQMVNLPLVERPICKASTGIRVTDNMFCAGYKPEEGKRGDACEGDSGGPFVMKNPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIRKMVDRFG,positive +GACAGCACGAAUAAAACCUGCGUAAAUCCGCCCCAUUUGUGUAAGGGUAGUGGG,MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINYDEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQAVAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQGIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADMDFSALLSQISS,positive +AATCCCAATGGATTGAACTGCCAACGAACG,MKEFEVKVASTAFVLVLFSLTINQILASETSTKFRSPVPAPTVPDWNHLPNEGNEENVVSAPKQDGASGGQKPYWTKREKMMKRLHAEPAGNTVRFRCAVDGNPKPQVLWYKNDLIVQKNDRVGGYKYRNQVLILESVVLSDKGNYMCVARNEYGSINHTYQLDVQERSASKPILAEGLPQNKSAYIGDDVTFKCKVYSDAHPHIQWLKSINNHNNAAPNYTVLKAAGVNTTDLDMEVLILKNVSFEEAGEYTCLAGNSIGISHQSAWLSVLPVPPPTTDTITKGIPNETNIIIYVMCGVLVILFGLAVVLVLYYHCYNGKDPPMLVRIENPDNIPPMTKIEHPTMLFGNTQAWQRMCMPMQEPFEFNIQLDLQWELQREDITLVERLDEGFFGQVFKADLVTCNNTRKEKMVCAVKMLKGNRNEKDVLDLLTEMDQMKRVGKHKNIINLLGVCTQNGPLWLVIEYAAQGNLRDYLRRNRPQNTLCNLVLPSEGRNPDDELPVPHGDTLTQKDIVSFAFQVARGLEFLAQKKCIHRDLAARNVLVTEELVMKIADFGLARDIRSCDYYRKHTRGHLPYKWMALEAMSDNIFTHATDVWSFGVLLWEIFSLAGSPYPGIKTHELVKFLRSGERLDKPQYASQEMYRLMRDCWEEDPSKRPNFRTLVEDLDRMLAESSTEVYIDFAAGCEAEYSESSEDESESQNSDEEDDDSVFERMRQIDSLSNGNIPFNEEDSSNSDPYVAPLLQNEENVLQNEHARLRSEA,positive +GAAUAUCUUCCGAAGCCGAACGGGAAAACCGGCAUCU,PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGKISKIGPENPYNTPVFAIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDESFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPXRXKNPEMVIYQYMDDLYVGSDLEIGQHRAKIEELRSHLLSWGFTTPDKKHQKEPPFLWMGYELHPDSWTVQPIELPEKDSWTVNE,positive +CAGAUACAGGCCAUGUGC,QELLCAASLISDRWVLTAAHCLLYPPWDKNFTVNDILVRIGKYARSRYERNMEKISTLEKIIIHPGYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDKQIVTSLLQAGHKGRVTGWGNLKEMWTVNMNEVQPSVLQMVNLPLVERPICKASTGIRVTDNMFCAGYKPEEGKRGDACEGDSGGPFVMKNPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIRKMVDRFG,positive +CAAGAACTCCTAAGTATAATGTGAGGGATCCGAAATTCTGCTCTTATGTATGGCAAGATT,MRKIVVAAIAVSLTTVSITASASADPSKDSKAQVSAAEAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKVKPSAASIDAAKKAGVNNGNPLDAVQQ,positive +GCCAGGGUUCAUCAUUCACGGCCGAUUUCGAAGCUCCUAACUCGAGACAC,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,positive +GGGAGGGAAUCAGUGAAUGCUUAUACAUCCCUCCUUGAGCAGUCGAUUAGUUUCGACAGGAGGCUCAC,MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPGPHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR,positive +GTAAATCGTCGACAGGAATTGGCGGGCCGG,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,positive +CAGCTCAGAAGCTTGATCCTGTGCGGGGCAAAGAGGTCCGAATTTGAAGGCTCCCCTGGACTCGAAGTCGTGCATCTGCA,QDRPIKFSTEGATSQSYKQFIEALRERLRGGLIHDIPVLPDPTTLQERNRYITVELSNSDTESIEVGIDVTNAYVVAYRAGTQSYFLRDAPSSASDYLFTGTDQHSLPFYGTYGDLERWAHQSRQQIPLGLQALTHGISFFRSGGNDNEEKARTLIVIIQMVAEAARFRYISNRVRVSIQTGTAFQPDAAMISLENNWDNLSRGVQESVQDTFPNQVTLTNIRNEPVIVDSLSHPTVAVLALMLFVCNPPNANQSPLLIRSIVEKSKICSSRYEPTVRIGGRDGMCVDVYDNGYHNGNRIIMWKCKDRLEENQLWTLKSDKTIRSNGKCLTTYGYAPGSYVMIYDCTSAVAEATYWEIWDNGTIINPKSALVLSAESSSMGGTLTVQTNEYLMRQGWRTGNNTSPFVTSISGYSDLCMQAQGSNVWMADCDSNKKEQQWALYTDGSIRSVQNTNNCLTSKDHKQGSTILLMGCSNGWASQRWVFKNDGSIYSLYDDMVMDVKGSDPSLKQIILWPYTGKPNQIWLTLF,positive +GGACCUUUGUACCCCAGAUGAUGGCUUCACUGCUUGAUGGGUACAAAUGGCAG,MIPPPRRSASSTPKDYRSSRDLQPWRGVSSGDAAETSQQSRHRRDAIADGGGRLKGAAQSSPSSGTRRSGPYAQGRAMPKNENIPKPGKQRLGPRKKKLSTLKKKILLDRLERWRDKQHEGALSTPSATASSEEAKCNNPFPLCPPGELSPPPSPPATICPAVVDKSTSYGQVGGANGERSVWAITIYNLVDQEDVEDDDDHAEIERDLWDMSSAFGVVRSVQVPRGTAVQVSDAEVSAAAAAGEPAAVAAKVAFATNAEAECARDGLNGRIVGGKPLLVRIHRCDGHFCGGVCPGDPDGSGLWRVAIENLIDEEDDLDDEDEYAEISANVSAMMGCYGKLVDVQVRRSSPSKGEVQEDVATRAATTAGATQAVVVTFGSLAEAEACVQGIKGCRVGGKELDAHVVLDSERVLPSNPAFKCDQEHAHSSDVAAAVAGQGDSMMKQEAGTEPSPCVDQDTAAAVASSTEWRVVIRGLIDEDDLQDDDDDYAEVCSDVTALVSSYGAVVGLDIPRGRETGSCCYGAEPGEAVVVFRSLQEAEACARGLSGRKVAGNILDAQVLTQPAPSQQGPLQGGASGTGPPVANRERKPAKECPLPQHQASSHQSCGKVPELDGSGPGMLRGFGNRVEDCCGRPKIACTDSDEPQAIAAAAPPGQSIEGPKTTALAKAGKRIQTKYQEAAALPKPPGVRGGLPNAYVNQPPDKEVNDLVFEMLQLLFKFQERARLSDPSKAKTRRRLVIGLREVLRGVKAKKVRLLIVAPNVDAVGGEGGLDDKVVEIIDKAREAEYPVVFALSKRKIGKALGKTIKVSAVGVYSFDGANEQQKQLKRRMETISSLPSPSPRQSDPPTDDALASPPSSSACGDSQDPAGKGSRV,positive +AGCACUUCAGAUAUGAUAACAGGUUCAAGGAUGUGCACA,MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICEVEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASSIVYKKEGEQVEFSFPLAFTVEKLTGSGELWWQAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLPQALPQYAGSGNLTLALEAKTGKLHQEVNLVVMRATQLQKNLTCEVWGPTSPKLMLSLKLENKEAKVSKREKAVWVLNPEAGMWQCLLSDSGQVLLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQAERMSQIKRLLSEKKTCQCPHRFQKTCSPI,positive +GCCUACGGCCACACCACCCUGAAAGUGCCUGAUCUCGUCUGAUCUCAGAAGCGAUACAGGGUCGGGCCUGGUUAGUACCUGGAUGGGAGACCGCCUGGGAAUACCAGGUGUCGUAGGCUUU,MAAKVASTSSEEAEGSLVTEGEMGEKALPVVYKRYICSFADCGAAYNKNWKLQAHLCKHTGEKPFPCKEEGCEKGFTSLHHLTRHSLTHTGEKNFTCDSDGCDLRFTTKANMKKHFNRFHNIKICVYVCHFENCGKAFKKHNQLKVHQFSHTQQLPYECPHEGCDKRFSLPSRLKRHEKVHAGYPCKKDDSCSFVGKTWTLYLKHVAECHQDLAVCDVCNRKFRHKDYLRDHQKTHEKERTVYLCPRDGCDRSYTTAFNLRSHIQSFHEEQRPFVCEHAGCGKCFAMKKSLERHSVVHDPEKRKLKEKCPRPKRSLASRLTGYIPPKSKEKNASVSGTEKTDSLVKNKPSGTETNGSLVLDKLTIQ,positive +UGGGGUAUCGCCAAGCGGUAAGGCACCGGAUUCUGAUUCCGGAGGUCGAGGUUCGAAUCCUCGUACCCCAGCCA,MSEAEARPTNFIRQIIDEDLASGKHTTVHTRFPPEPNGYLHIGHAKSICLNFGIAQDYKGQCNLRFDDTNPVKEDIEYVESIKNDVEWLGFHWSGNVRYSSDYFDQLHAYAIELINKGLAYVDELTPEQIREYRGTLTQPGKNSPYRDRSVEENLALFEKMRAGGFEEGKACLRAKIDMASPFIVMRDPVLYRIKFAEHHQTGNKWCIYPMYDFTHCISDALEGITHSLCTLEFQDNRRLYDWVLDNITIPVHPRQYEFSRLNLEYTVMSKRKLNLLVTDKHVEGWDDPRMPTISGLRRRGYTAASIREFCKRIGVTKQDNTIEMASLESCIREDLNENAPRAMAVIDPVKLVIENYQGEGEMVTMPNHPNKPEMGSRQVPFSGEIWIDRADFREEANKQYKRLVLGKEVRLRNAYVIKAERVEKDAEGNITTIFCTYDADTLSKDPADGRKVKGVIHWVSAAHALPVEIRLYDRLFSVPNPGAADDFLSVINPESLVIKQGFAEPSLKDAVAGKAFQFEREGYFCLDSRHSTAEKPVFNRTVGLRDTWAKVGE,positive +GGGGGAGGACGCGTAGTGGGGGGCCCATGGTTGTGTGG,MKPGGNTIVIWMYAVATWLCFGSTSGWSFTLEDNNIFPKQYPIINFTTAGATVQSYTNFIRAVRGRLTTGADVRHEIPVLPNRVGLPINQRFILVELSNHAELSVTLALDVTNAYVVGYRAGNSAYFFHPDNQEDAEAITHLFTDVQNRYTFAFGGNYDRLEQLAGNLRENIELGNGPLEEAISALYYYSTGGTQLPTLARSFIICIQMISEAARFQYIEGEMRTRIRYNRRSAPDPSVITLENSWGRLSTAIQESNQGAFASPIQLQRRNGSKFSVYDVSILIPIIALMVYRCAPPPSSQFSLLIRPVVPNFNADVCMDPEPIVRIVGRNGLCVDVRDGRFHNGNAIQLWPCKSNTDANQLWTLKRDNTIRSNGKCLTTYGYSPGVYVMIYDCNTAATDATRWQIWDNGTIINPRSSLVLAATSGNSGTTLTVQTNIYAVSQGWLPTNNTQPFVTTIVGLYGLCLQANSGQVWIEDCSSEKAEQQWALYADGSIRPQQNRDNCLTSDSNIRETVVKILSCGPASSGQRWMFKNDGTILNLYSGLVLDVRASDPSLKQIILYPLHGDPNQIWLPLF,positive +AGCAGCACAGAGGTCAGATGGTTACTGCGGGGTATGGGGACTGGTTGCGTGGCTTGGTGTCCTATGCGTGCTACCGTGAA,MLSWGYFLFLLPTLPGAQSQVQLVESGGDVRKPGDSLRLSCKGSGFTFSNYWLGWVRQAPGKALNGSLPLTPLAAAPTYIPGVSGRFTISRDNARALLHLDMSDLRPEDTGRYHCER,positive +AAGACGGCCCGGUGUGCAGCCGGAGAUCCGAGACUUGCU,MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC,positive +ACCGAAAAAGACCUGACUUCUAUACUAAGUCUACGUUCC,MQQGQMAYDRAITVFSPDGRLFQVEYAREAVKKGSTALGMKFANGVLLISDKKVRSRLIEQNSIEKIQLIDDYVAAVTSGLVADARVLVDFARISAQQEKVTYGSLVNIENLVKRVADQMQQYTQYGGVRPYGVSLIFAGIDQIGPRLFDCDPAGTINEYKATAIGSGKDAVVSFLEREYKENLPEKEAVTLGIKALKSSLEEGEELKAPEIASITVGNKYRIYDQEEVKKFL,positive +GGAGACCGTACCATCTGTTCGTGGAAGCGCTTTGCTCGTCCATTAGCCTTGTGCTCGTGC,MKKTLIALAIAASAASGMAHAWMTGDFNGSVDIGGSITADDYRQKWEWKVGTGLNGFGNVLNDLTNGGTKLTITVTGNKPILLGRTKEAFATPVTGGVDGIPHIAFTDYEGASVVLRNPDGETNKKGLAYFVLPMKNAEGTKVGSVKVNASYAGVLGRGGVTSADGELLSLFADGLSSIFYGGLPRGSELSAGSAAAARTKLFGSLSRNDILGQIQRVNANITSLVDVAGSYRENMEYTDGTVVSAAYALGIANGQTIEATFNQAVTTSTQWSAPLNVAITYY,positive +AAUAACUU,PGGVQVSLLKEYYEDGYHIVRDIDSTVGVSISDASLPPRTWNGFLAPKTYKNVYIDTYHNQVFDDIFRTFTIDQHVKLACSLPHGRLRGADKPLIVKEWSGAMTDCAMYLNGRGIGSRFDGSFPSGKPSGACGARSKGSSSELSAQQKKDTLRYIEAQLDAFEVGAGWYFWTW,positive +UACCGAAAACGCAUGCCUCUAGCCGUUCGAUACGAGCUGAGCAGCGGGCCAGUACUACAAGCUUCUGGACUCGGU,MASTSRLDALPRVTCPNHPDAILVEDYRAGDMICPECDRVIDVGSEWRTFSNDKATKDPSRVGDSQNPLLSDGDLSTMIGKGTGAASFDEFGNSKYQNRRTMSSSDRAMMNAFKEITTMADRINLPRNIVDRTNNLFKQVYEQKSLKGRANDAIASACLYIACRQEGVPRTFKEICAVSRISKKEIGRCFKLILKALETSVDLITTGDFMSRFCSNLCLPKQVQMAATHIA,positive +GACAGCGUGCCUAGAAGUCCAAGCUUAAAUAACCACGCUCGACAAGC,MPFVNKQFNYKDPVNGVDIAYIKIPNVGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAGHRLYGIAINPNRVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNRKTYLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLKNFTGLFEFYKLLCVRGIITSKTKSLDKGYNKALNDLCIKVNNWDLFFSPSEDNFTNDLNKGEEITSDTNIEAAEENISLDLIQQYYLTFNFDNEPENISIENLSSDIIGQLELMPNIERFPNGKKYELDKYTMFHYLRAQEFEHGKSRIALTNSVNEALLNPSRVYTFFSSDYVKKVNKATEAAMFLGWVEQLVYDFTDETSEVSTTDKIADITIIIPYIGPALNIGNMLYKDDFVGALIFSGAVILLEFIPEIAIPVLGTFALVSYIANKVLTVQTIDNALSKRNEKWDEVYKYIVTNWLAKVNTQIDLIRKKMKEALENQAEATKAIINYQYNQYTEEEKNNINFNIDDLSSKLNESINKAMININKFLNQCSVSYLMNSMIPYGVKRLEDFDASLKDALLKYIYDNRGTLIGQVDRLKDKVNNTLSTDIPFQLSKYVDNQRLLSTFTEYIKNIINTSILNLRYESNHLIDLSRYASKINIGSKVNFDPIDKNQIQLFNLESSKIEVILKNAIVYNSMYENFSTSFWIRIPKYFNSISLNNEYTIINCMENNSGWKVSLNYGEIIWTLQDTQEIKQRVVFKYSQMINISDYINRWIFVTITNNRLNNSKIYINGRLIDQKPISNLGNIHASNNIMFKLDGCRDTHRYIWIKYFNLFDKELNEKEIKDLYDNQSNSGILKDFWGDYLQYDKPYYMLNLYDPNKYVDVNNVGIRGYMYLKGPRGSVMTTNIYLNSSLYRGTKFIIKKYASGNKDNIVRNNDRVYINVVVKNKEYRLATNASQAGVEKILSALEIPDVGNLSQVVVMKSKNDQGITNKCKMNLQDNNGNDIGFIGFHQFNNIAKLVASNWYNRQIERSSRTLGCSWEFIPVDDGWGERPL,positive +AAGCCGGAUGCACGAAUAUUGAGGUAAGCG,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,positive +CGAUACAGCACUGAUUGCGGUCGAGGUAGCUUGAUGGGCC,MSDLANSEKYYDEDPYGFEDESAPITAEDSWAVISAFFREKGLVSQQLDSFNQFVDYTLQDIICEDSTLILEQLAQHTTESDNISRKYEISFGKIYVTKPMVNESDGVTHALYPQEARLRNLTYSSGLFVDVKKRTYEAIDVPGRELKYELIAEESEDDSESGKVFIGRLPIMLRSKNCYLSEATESDLYKLKECPFDMGGYFIINGSEKVLIAQERSAGNIVQVFKKAAPSPISHVAEIRSALEKGSRFISTLQVKLYGREGSSARTIKATLPYIKQDIPIVIIFRALGIIPDGEILEHICYDVNDWQMLEMLKPCVEDGFVIQDRETALDFIGRRGTALGIKKEKRIQYAKDILQKEFLPHITQLEGFESRKAFFLGYMINRLLLCALDRKDQDDRDHFGKKRLDLAGPLLAQLFKTLFKKLTKDIFRYMQRTVEEAHDFNMKLAINAKTITSGLKYALATGNWGEQKKAMSSRAGVSQVLNRYTYSSTLSHLRRTNTPIGRDGKLAKPRQLHNTHWGLVCPAETPEGQACGLVKNLSLMSCISVGTDPMPIITFLSEWGMEPLEDYVPHQSPDATRVFVNGVWHGVHRNPARLMETLRTLRRKGDINPEVSMIRDIREKELKIFTDAGRVYRPLFIVEDDESLGHKELKVRKGHIAKLMATEYQDIEGGFEDVEEYTWSSLLNEGLVEYIDAEEEESILIAMQPEDLEPAEANEENDLDVDPAKRIRVSHHATTFTHCEIHPSMILGVAASIIPFPDHNQSPRNTYQSAMGKQAMGVFLTNYNVRMDTMANILYYPQKPLGTTRAMEYLKFRELPAGQNAIVAIACYSGYNQEDSMIMNQSSIDRGLFRSLFFRSYMDQEKKYGMSITETFEKPQRTNTLRMKHGTYDKLDDDGLIAPGVRVSGEDVIIGKTTPISPDEEELGQRTAYHSKRDASTPLRSTENGIVDQVLVTTNQDGLKFVKVRVRTTKIPQIGDKFASRHGQKGTIGITYRREDMPFTAEGIVPDLIINPHAIPSRMTVAHLIECLLSKVAALSGNEGDASPFTDITVEGISKLLREHGYQSRGFEVMYNGHTGKKLMAQIFFGPTYYQRLRHMVDDKIHARARGPMQVLTRQPVEGRSRDGGLRFGEMERDCMIAHGAASFLKERLMEASDAFRVHICGICGLMTVIAKLNHNQFECKGCDNKIDIYQIHIPYAAKLLFQELMAMNITPRLYTDRSRDF,positive +UAGGGAGAGAACUGUGUCAGAAUGUAGUGAACCAGACACGGAGUGGAGUA,MSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEMLDRHHTHFCPLEGESWQDFLRNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAFLCQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERETPTTDSMPPLLRQAIELFDHQGAEPAFLFGLELIICGLEKQLKCESGS,positive +CCACCGAUCGCAUCAGCUCAUGGCCCCUCCCGACCCGCCA,MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYTFLLPEMDNCRSSSSPYVSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQDNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVLVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF,positive +CGTCTTGCATAATATAAAATTTTGTTTTGAGTTGTAATCGAATGCGGTCT,MAITKINDCFELLSMVTYADKLKSLIKKEFSISFEEFAVLTYISENKEKEYYLKDIINHLNYKQPQVVKAVKILSQEDYFDKKRNEHDERTVLILVNAQQRKKIESLLSRVNKRITEANNEIEL,positive +UAUGUUGUGUGUGUGUUGUUUUUGUGUUUUGUUUU,MAWYWWRRRRRRGWWKPRRRRWRRRRARRRGPARRHRARRRIVRHPCNGQTSSGNRVPRSVQAVDPKYVSLQLVWHSWDFRRGLFGQAGIKRMQQESDALTLSPVHRPKRPKRDTQVKEKTPEKDSDSAVQLRRLQPWIHSSQETKDEEEEIPEGPVQEQLLQQLQQQRLLRVQLESIAQEVLKIRRGHSLHPLLSSHA,positive +CCUGCCCUUUCCAACACCCGCCGAAACUCA,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,positive +GACCGGUGUGUCCUGAUCCAACUGCCACAAGUACCAUAUGCAGGUGACGU,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,positive +CCCAGGAUCACCGGG,MASNFTQFVLVDNGGTGDVTVAPSNFANGVAEWISSNSRSQAYKVTCSVRQSSAQNRKYTIKVEVPKVATQTVGGVELPVAAWRSYLNMELTIPIFATNSDCELIVKAMQGLLKDGNPIPSAIAANSGIY,positive +ACACGGGCCGTGAACGCAGCGAGTTCGCCCGTCGTGACATT,MPSNQEARLFLAVLVLAQVLPILVDSAAEKGFKQAFWQPLCQVSEELDDQPKGALFTLQAAASKIQKMRDAALRASIYAEINHGTNRAKAAVIVANHYAMKADSGLEALKQTLSSQEVTATATASYLKGRIDEYLNLLLQTKESGTSGCMMDTSGTNTVTKAGGTIGGVPCKLQLSPIQPKRPAATYLGKAGYVGLTRQADAANNFHDNDAECRLASGHNTNGLGKSGQLSAAVTMAAGYVTVANSQTAVTVQALDALQEASGAAHQPWIDAWKAKKALTGAETAEFRNETAGIAGKTGVTKLVEEALLKKKDSEASEIQTELKKYFSGHENEQWTAIEKLISEQPVAQNLVGDNQPTKLGELEGNAKLTTILAYYRMETAGKFEVLTQKHKPAESQQQAAETEGSCNKKDQNECKSPCKWHNDAENKKCTLDKEEAKKVADETAKDGKTGNTNTTGSSNSFVISKTPLWLAVLLF,positive +GGTTGGTATGGTTGG,ASFTCLAIWALASAGVVPLVLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAAFFFVPVIISTVCYVSIIRCLSSSAVANRSKK,positive +TCGGATGCGCCGAGTCTCCGTTTACCTTCGT,MGLLGILCFLIFLGKTWGQEQTYVISAPKIFRVGASENIVIQVYGYTEAFDATISIKSYPDKKFSYSSGHVHLSSENKFQNSAILTIQPKQLPGGQNPVSYVYLEVVSKHFSKSKRMPITYDNGFLFIHTDKPVYTPDQSVKVRVYSLNDDLKPAKRETVLTFIDPEGSEVDMVEEIDHIGIISFPDFKIPSNPRYGMWTIKAKYKEDFSTTGTAYFEVKEYVLPHFSVSIEPEYNFIGYKNFKNFEITIKARYFYNKVVTEADVYITFGIREDLKDDQKEMMQTAMQNTMLINGIAQVTFDSETAVKELSYYSLEDLNNKYLYIAVTVIESTGGFSEEAEIPGIKYVLSPYKLNLVATPLFLKPGIPYPIKVQVKDSLDQLVGGVPVTLNAQTIDVNQETSDLDPSKSVTRVDDGVASFVLNLPSGVTVLEFNVKTDAPDLPEENQAREGYRAIAYSSLSQSYLYIDWTDNHKALLVGEHLNIIVTPKSPYIDKITHYNYLILSKGKIIHFGTREKFSDASYQSINIPVTQNMVPSSRLLVYYIVTGEQTAELVSDSVWLNIEEKCGNQLQVHLSPDADAYSPGQTVSLNMATGMDSWVALAAVDSAVYGVQRGAKKPLERVFQFLEKSDLGCGAGGGLNNANVFHLAGLTFLTNANADDSQENDEPCKEILRPRRTLQKKIEEIAAKYKHSVVKKCCYDGACVNNDETCEQRAARISLGPRCIKAFTECCVVASQLRANISHKDMQLGRLHMKTLLPVSKPEIRSYFPESWLWEVHLVPRRKQLQFALPDSLTTWEIQGVGISNTGICVADTVKAKVFKDVFLEMNIPYSVVRGEQIQLKGTVYNYRTSGMQFCVKMSAVEGICTSESPVIDHQGTKSSKCVRQKVEGSSSHLVTFTVLPLEIGLHNINFSLETWFGKEILVKTLRVVPEGVKRESYSGVTLDPRGIYGTISRRKEFPYRIPLDLVPKTEIKRILSVKGLLVGEILSAVLSQEGINILTHLPKGSAEAELMSVVPVFYVFHYLETGNHWNIFHSDPLIEKQKLKKKLKEGMLSIMSYRNADYSYSVWKGGSASTWLTAFALRVLGQVNKYVEQNQNSICNSLLWLVENYQLDNGSFKENSQYQPIKLQGTLPVEARENSLYLTAFTVIGIRKAFDICPLVKIDTALIKADNFLLENTLPAQSTFTLAISAYALSLGDKTHPQFRSIVSALKREALVKGNPPIYRFWKDNLQHKDSSVPNTGTARMVETTAYALLTSLNLKDINYVNPVIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVKQLRLSMDIDVSYKHKGALHNYKMTDKNFLGRPVEVLLNDDLIVSTGFGSGLATVHVTTVVHKTSTSEEVCSFYLKIDTQDIEASHYRGYGNSDYKRIVACASYKPSREESSSGSSHAVMDISLPTGISANEEDLKALVEGVDQLFTDYQIKDGHVILQLNSIPSSDFLCVRFRIFELFEVGFLSPATFTVYEYHRPDKQCTMFYSTSNIKIQKVCEGAACKCVEADCGQMQEELDLTISAETRKQTACKPEIAYAYKVSITSITVENVFVKYKATLLDIYKTGEAVAEKDSEITFIKKVTCTNAELVKGRQYLIMGKEALQIKYNFSFRYIYPLDSLTWIEYWPRDTTCSSCQAFLANLDEFAEDIFLNGC,positive +TTACCGTGATGTATGATATGCATCCACCGTG,MDKLVVNYYEYKHPIINKDLAIGAHGGKKFPTLGAWYDVINEYEFQTRCPIILKNSHRNKHFTFACHLKNCPFKVLLSYAGNAASSETSSPSANNNTNPPGTPDHIHHHSNNMNNEDNDNNNGSNNKVSNDSKLDFVTDDLEYHLANTHPDDTNDKVESRSNEVNGNNDDDADANNIFKQQGVTIKNDTEDDSINKASIDRGLDDESGPTHGNDSGNHRHNEEDDVHTQMTKNYSDVVNDEDINVAIANAVANVDSQSNNKHDGKDDDATNNNDGQDNNTNNDHNNNSNINNNNVGSHGISSHSPSSIRDTSMNLDVFNSATDDIPGPFVVTKIEPYHSHPLEDNLSLGKFILTKIPKILQNDLKFDQILESSYNNSNHTVSKFKVSHYVEESGLLDILMQRYGLTAEDFEKRLLSQIARRITTYKARFVLKKKKMGEYNDLQPSSSSNNNNNNDGELSGTNLRSNSIDYAKHQEISSAGTSSNTTKNVNNNKNDSNDDNNGNNNNDASNLMESVLDKTSSHRYQPKKMPSVNKWSKPDQITHSDVSMVGLDESNDGGNENVHPTLAEVDAQEARETAQLAIDKINSYKRSIDDKNGDGHNNSSRNVVDENLINDMDSEDAHKSKRQHLSDITLEERNEDDKLPHEVAEQLRLLSSHLKEVENLHQNNDDDVDDVMVDVDVESQYNKNTTHHNNHHSQPHHDEEDVAGLIGKADDEEDLSDENIQPELRGQ,positive +ACAAGAAGGACAGCACGAAUAAAACCUGCGUAAAUCCGCCCCAUUUGUGUAAGGGUAGUGGG,MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINYDEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQAVAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQGIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADMDFSALLSQISS,positive +AUGACGUACCCGCACAAGCCACCACAAGUCUUAAUCGCGCCACCCUUGC,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,positive +GATGTGGGTGTAGTTGGAGGGTAAACGTT,MKKRKVLIPLMALSTILVSSTGNLEVIQAEVKQENRLLNESESSSQGLLGYYFSDLNFQAPMVVTSSTTGDLSIPSSELENIPSENQYFQSAIWSGFIKVKKSDEYTFATSADNHVTMWVDDQEVINKASNSNKIRLEKGRLYQIKIQYQRENPTEKGLDFKLYWTDSQNKKEVISSDNLQLPELKQKSSNSRKKRSTSAGPTVPDRDNDGIPDSLEVEGYTVDVKNKRTFLSPWISNIHEKKGLTKYKSSPEKWSTASDPYSDFEKVTGRIDKNVSPEARHPLVAAYPIVHVDMENIILSKNEDQSTQNTDSQTRTISKNTSTSRTHTSEVHGNAEVHASFFDIGGSVSAGFSNSNSSTVAIDHSLSLAGERTWAETMGLNTADTARLNANIRYVNTGTAPIYNVLPTTSLVLGKNQTLATIKAKENQLSQILAPNNYYPSKNLAPIALNAQDDFSSTPITMNYNQFLELEKTKQLRLDTDQVYGNIATYNFENGRVRVDTGSNWSEVLPQIQETTARIIFNGKDLNLVERRIAAVNPSDPLETTKPDMTLKEALKIAFGFNEPNGNLQYQGKDITEFDFNFDQQTSQNIKNQLAELNATNIYTVLDKIKLNAKMNILIRDKRFHYDRNNIAVGADESVVKEAHREVINSSTEGLLLNIDKDIRKILSGYIVEIEDTEGLKEVINDRYDMLNISSLRQDGKTFIDFKKYNDKLPLYISNPNYKVNVYAVTKENTIINPSENGDTSTNGIKKILIFSKKGYEIG,positive +GGCGATAGTTTCTATAGCAAGGTACAGCATTCTCTCTCCCTATAGAACCAATCCAGTACTAGC,MKRASAGGSRLLAWVLWLQAWQVAAPCPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDNPWVCDCRARPLWAWLQKFRGSSSEVPCSLPQRLAGRDLKRLAANDLQGCAVATGPYHPIWTGRATDEEPLGLPKCCQPDAADKASVLEPGRPASAGNALKGRVPPGDSPPGNGSGPRHINDSPFGTLPGSAEPPLTAVRPEGSEPPGFPTSGPRRRPGCSRKNRTRSHCRLGQAGSGGGGTGDSEGSGALPSLTCSLTPLGLALVLWTVLGPC,positive +TAGGGAATTCGTCGACGGATCCCGCATGGGAGCCGGCATCTCCTGGGACCATGAACTCGTTCGCTTATATGCCGGCGCATGCGTCGACCTGGAG,MAMQMQLEANADTSVEEESFGPQPISRLEQCGINANDVKKLEEAGFHTVEAVAYAPKKELINIKGISEAKADKILAEAAKLVPMGFTTATEFHQRRSEIIQITTGSKELDKLLQGGIETGSITEMFGEFRTGKTQICHTLAVTCQLPIDRGGGEGKAMYIDTEGTFRPERLLAVAERYGLSGSDVLDNVAYARAFNTDHQTQLLYQASAMMVESRYALLIVDSATALYRTDYSGRGELSARQMHLARFLRMLLRLADEFGVAVVITNQVVAQVDGAAMFAADPKKPIGGNIIAHASTTRLYLRKGRGETRICKIYDSPCLPEAEAMFAINADGVGDAKD,positive +CGUCCCGUAGGCCAAUUGCGUCCCACCUUAACGUCCGCC,MGVLLTQRTLLSLVLALLFPSMASMAAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQGLDVPKLREHCRERPGAFPSEETLRGLGRRGFLQTLNATLGCVLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILGLRNNIYCMAQLLDNSDTAEPTKAGRGASQPPTPTPASDAFQRKLEGCRFLHGYHRFMHSVGRVFSKWGESPNRSRRHSPHQALRKGVRRTRPSRKGKRLMTRGQLPR,positive +AGCGCGCACCTACTGTGATGAAGAAGTCACAGCAAGGCCC,MPSNQEARLFLAVLVLAQVLPILVDSAAEKGFKQAFWQPLCQVSEELDDQPKGALFTLQAAASKIQKMRDAALRASIYAEINHGTNRAKAAVIVANHYAMKADSGLEALKQTLSSQEVTATATASYLKGRIDEYLNLLLQTKESGTSGCMMDTSGTNTVTKAGGTIGGVPCKLQLSPIQPKRPAATYLGKAGYVGLTRQADAANNFHDNDAECRLASGHNTNGLGKSGQLSAAVTMAAGYVTVANSQTAVTVQALDALQEASGAAHQPWIDAWKAKKALTGAETAEFRNETAGIAGKTGVTKLVEEALLKKKDSEASEIQTELKKYFSGHENEQWTAIEKLISEQPVAQNLVGDNQPTKLGELEGNAKLTTILAYYRMETAGKFEVLTQKHKPAESQQQAAETEGSCNKKDQNECKSPCKWHNDAENKKCTLDKEEAKKVADETAKDGKTGNTNTTGSSNSFVISKTPLWLAVLLF,positive +TTGCGCGTTAATTGGGGGGGTGGGTGGGTT,MQLPLALCLVCLLVHTAFRVVEGQGWQAFKNDATEIIPELGEYPEPPPELENNKTMNRAENGGRPPHHPFETKDVSEYSCRELHFTRYVTDGPCRSAKPVTELVCSGQCGPARLLPNAIGRGKWWRPSGPDFRCIPDRYRAQRVQLLCPGGEAPRARKVRLVASCKCKRLTRFHNQSELKDFGTEAARPQKGRKPRPRARSAKANQAELENAY,positive +AGCAGCACAGAGGTCAGATGGCCTATATTTATAAAGACAGGAGAGTAATGTCGAGCAGAACCTATGCGTGCTACCGTGAA,MLSWGYFLFLLPTLPGAQSQVQLVESGGDVRKPGDSLRLSCKGSGFTFSNYWLGWVRQAPGKALNGSLPLTPLAAAPTYIPGVSGRFTISRDNARALLHLDMSDLRPEDTGRYHCER,positive +GGGAGAAUUCCGACCAGAAGUUCGAUACGCCGUGGGGUGACGUUGGCUACCCUUUCCUCUCUCCUCCUUCUUCU,QSVEESRGGLIKPTDTLTLTCTVSGFSLSSYGEVWDRQAPGNGLEYIGAIGNSGSTYYASWAKSRSTITRNTNLNTVTLKMTSLTAADTATYFCAR,positive +UUUUUUUAAUUUUUGUUUAUUAAUCUUUAUGCUUUUUUCAUUUAUCUAUAAUUUUUAUU,MEDLVVEVRGSNGAFYKAFVKDVHEDSITVAFENNWQPDRQIPFHDVRFPPPVGYNKDINESDEVEVYSRANEKEPCCWWLAKVRMIKGEFYVIEYAACDATYNEIVTIERLRSVNPNKPATKETFHKIKLDVPEDLRQMCAKESAHKDFKKAVGAFSVTYDPENYQLVVLSISEVTSKRAHMLIDMHFRSLRTKLSLILRNEEASKQLESSRQLASRFHEQFVVREDLMGLAIGTHGANIQQARKVPGVTAIDLDEDTCTFHIYGEDQDAVKKARSFLEFAEDVIQVPRNLVGKVIGKKKKK,positive +ACCUUCUGUUCAUAUCGUGACCAACCCAAUAGAUUGUGAUAAAGGAGGAGGAGGA,MVKSHIGSWILVLFVAMWSDVGLCKKRPKPGGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGTHGQWNKPSKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGSDYEDRYYRENMHRYPNQVYYRPVDQYSNQNNFVHDCVNITVKEHTVTTTTKGENFTETDIKMMERVVEQMCITQYQRESQAYYQRGASVILFSSPPVILLISFLIFLIVG,positive +GAGGACGAUGCGGACUAGCCUCAUCAGCUCAUGUGCCCCUC,MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYTFLLPEMDNCRSSSSPYVSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQDNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVLVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF,positive +CUUUCCUAGCGCACAUGCGACCUCUAUGCGUAAUACGAACGUUGACGGU,MRKIVVAAIAVSLTTVSITASASADPSKDSKAQVSAAEAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKVKPSAASIDAAKKAGVNNGNPLDAVQQ,positive +GGUCCGUAGUUCUGGCUGACUGGUUACCCGGUCGUACAGCUCG,MAGPQALAFGLLLAVVTATLAAAQRDCVCDNYKLATSCSLNEYGECQCTSYGTQNTVICSKLASKCLAMKAEMTHSKSGRRIKPEGAIQNNDGLYDPDCDEQGLFKAKQCNGTATCWCVNTAGVRRTDKDTEITCSERVRTYWIIIELKHKERESPYDHQSLQTALQEAFTSRYKLNQKFIKNIMYENNVITIDLMQNSSQKTQDDVDIADVAYYFEKDVKGESLFHSSKSMDLRVNGEPLDLDPGQTLIYYVDEKAPEFSMQGLTAGIIAVIVVVSLAVIAGIVVLVISTRKKSAKYEKAEIKEMGEIHRELNA,positive +AGUCAUUUAUAAGAUCCGACAACCUGUCUAUUAGUUGCGCCGAUUAAGUGACU,PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGKISKIGPENPYNTPVFAIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDESFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPXRXKNPEMVIYQYMDDLYVGSDLEIGQHRAKIEELRSHLLSWGFTTPDKKHQKEPPFLWMGYELHPDSWTVQPIELPEKDSWTVNE,positive +GCAAUGGUACGGUACUUCCUUUGGAAGAUAGCUGGAGAACUAACCAAAAGUGCACGCUACUUUGCUAA,MARVRGPRLPGCLALAALFSLVHSQHVFLAHQQASSLLQRARRANKGFLEEVRKGNLERECLEEPCSREEAFEALESLSATDAFWAKYTACESARNPREKLNECLEGNCAEGVGMNYRGNVSVTRSGIECQLWRSRYPHKPEINSTTHPGADLRENFCRNPDGSITGPWCYTTSPTLRREECSVPVCGQDRVTVEVIPRSGGSTTSQSPLLETCVPDRGREYRGRLAVTTSGSRCLAWSSEQAKALSKDQDFNPAVPLAENFCRNPDGDEEGAWCYVADQPGDFEYCDLNYCEEPVDGDLGDRLGEDPDPDAAIEGRTSEDHFQPFFNEKTFGAGEADCGLRPLFEKKQVQDQTEKELFESYIEGRIVEGQDAEVGLSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTVDDLLVRIGKHSRTRYERKVEKISMLDKIYIHPRYNWKENLDRDIALLKLKRPIELSDYIHPVCLPDKQTAAKLLHAGFKGRVTGWGNRRETWTTSVAEVQPSVLQVVNLPLVERPVCKASTRIRITDNMFCAGYKPGEGKRGDACEGDSGGPFVMKSPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDRLGS,positive +GGUAGAUACGAUGGAGGUGUAUUUUAUGUGCGUAUUUGGAGGCAUGACGCGCAGCCA,MANLGYWLLALFVTMWTDVGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGTWGQPHGGGWGQPHGGSWGQPHGGSWGQPHGGGWGQGGGTHNQWNKPSKPKTNLKHVAGAAAAGAVVGGLGGYMLGSAMSRPMIHFGNDWEDRYYRENMYRYPNQVYYRPVDQYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCVTQYQKESQAYYDGRRSSSTVLFSSPPVILLISFLIFLIVG,positive +GGCAGCGAAAGCGGAACAAGUAUGUAACCAUGCCUCGGCAACUUUACAUGCGUAGCCAAACCCA,MTSHYVIAIFALMSSCLATAGPEPGALCELSPVSASHPVQALMESFTVLSGCASRGTTGLPQEVHVLNLRTAGQGPGQLQREVTLHLNPISSVHIHHKSVVFLLNSPHPLVWHLKTERLATGVSRLFLVSEGSVVQFSSANFSLTAETEERNFPHGNEHLLNWARKEYGAVTSFTELKIARNIYIKVGEDQVFPPKCNIGKNFLSLNYLAEYLQPKAAEGCVMSSQPQNEEVHIIELITPNSNPYSAFQVDITIDIRPSQEDLEVVKNLILILKCKKSVNWVIKSFDVKGSLKIIAPNSIGFGKESERSMTMTKSIRDDIPSTQGNLVKWALDNGYSPITSYTMAPVANRFHLRLENNAEEMGDEEVHTIPPELRILLDPGALPALQNPPIRGGEGQNGGLPFPFPDISRRVWNEEGEDGLPRPKDPVIPSIQLFPGLREPEEVQGSVDIALSVKCDNEKMIVAVEKDSFQASGYSGMDVTLLDPTCKAKMNGTHFVLESPLNGCGTRPRWSALDGVVYYNSIVIQVPALGDSSGWPDGYEDLESGDNGFPGDMDEGDASLFTRPEIVVFNCSLQQVRNPSSFQEQPHGNITFNMELYNTDLFLVPSQGVFSVPENGHVYVEVSVTKAEQELGFAIQTCFISPYSNPDRMSHYTIIENICPKDESVKFYSPKRVHFPIPQADMDKKRFSFVFKPVFNTSLLFLQCELTLCTKMEKHPQKLPKCVPPDEACTSLDASIIWAMMQNKKTFTKPLAVIHHEAESKEKGPSMKEPNPISPPIFHGLDTLTVMGIAFAAFVIGALLTGALWYIYSHTGETAGRQQVPTSPPASENSSAAHSIGSTQSTPCSSSSTA,positive +CGGACGAAATTCGTCCCTGTGTG,GLVKKAHEISVLCDAELALIIFSPKGKLYEYATDSKMEIILERYERYTYAEKALIASDPDVQGNWCHEYIKLKAKFEALNKSQRHLMGEQLDTLNQKELLQLETKLEGSLKNVRSRKTQLMLDSISELQEKGKSLQEQNTCLEKEILGKQKDKAPKQHVQWEKQNQPPPTSSAPMPFLIGDIHPTPNIRNFQGRTVADA,positive +TACCAAGATCCCACAACTAGCCGACCACAATTGCCGGCCA,MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA,positive +AACUAGCAGGCAGAGAAGAGUGGGUGCGACCACAGGAUGUUAUGGCCUG,MSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEMLDRHHTHFCPLEGESWQDFLRNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAFLCQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERETPTTDSMPPLLRQAIELFDHQGAEPAFLFGLELIICGLEKQLKCESGS,positive +CACCGCAUUGAGCCCAGAGACGCCACAGAC,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,positive +GGGCGAAUUCAACUGCCAUCUAGGCAGUAACCAGGAGUUAGUAGGACAAGUUUCGUCC,WWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMKSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGSKGKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMKVAKNAQNINPTSLQNSQNFA,positive +CTTCTGCCCGCCTCCTTCCGACGGTGATTGTTATCTCAGAGCCAGTTTGAACAACCCGGGAGACGAGATAGGCGGACACT,MEGMLKGEGPGPLPPLLQQYVELRDQYPDYLLLFQVGDFYECFGEDAERLARALGLVLTHKTSKDFTTPMAGIPLRAFEAYAERLLKMGFRLAVADQVEPAEEAEGLVRREVTQLLTPGTLLQESLLPREANYLAAIATGDGWGLAFLDVSTGEFKGTVLKSKSALYDELFRHRPAEVLLAPELLENGAFLDEFRKRFPVMLSEAPFEPEGEGPLALRRARGALLAYAQRTQGGALSLQPFRFYDPGAFMRLPEATLRALEVFEPLRGQDTLFSVLDETRTAPGRRLLQSWLRHPLLDRGPLEARLDRVEGFVREGALREGVRRLLYRLADLERLATRLELGRASPKDLGALRRSLQILPELRALLGEEVGLPDLSPLKEELEAALVEDPPLKVSEGGLIREGYDPDLDALRAAHREGVAYFLELEERERERTGIPTLKVGYNAVFGYYLEVTRPYYERVPKEYRPVQTLKDRQRYTLPEMKEKEREVYRLEALIRRREEEVFLEVRERAKRQAEALREAARILAELDVYAALAEVAVRYGYVRPRFGDRLQIRAGRHPVVERRTEFVPNDLEMAHELVLITGPNMAGKSTFLRQTALIALLAQVGSFVPAEEAHLPLFDGIYTRIGASDDLAGGKSTFMVEMEEVALILKEATENSLVLLDEVGRGTSSLDGVAIATAVAEALHERRAYTLFATHYFELTALGLPRLKNLHVAAREEAGGLVFYHQVLPGPASKSYGVEVAAMAGLPKEVVARARALLQAMAARREGALDAVLERLLALDPDRLTPLEALRLLQELKALALGAPLDTMKG,positive +TCCGATAAGTATGTGACAACCTACAAAGCACTCCACGCCT,MAIPKELLVLLLGIAILSKVAECAAFGSRRGLVETVFDVTRFGARPNTPADSTRGLMMAWRSACQSPGPAKVVIPPGTYTTGETIFQGPCTSPRPITIEIQGTLLSNTDMSLYTRAAWISIEHVDGIVITGGGTLNGQGKSSWQFADKSGSTPPLPSSLVFQTVRSSSIKNLNFVDAKGVHLKITDSSDISVSNIKITAPGDSPNTDGLHISDTINVNVTDSTIGTGDDCISIGDGNSNVYISNINCGPGHGISIGSLGKRLDETDVKGVTVRNCTFRGTTNGARIKTYMGSPSLQVSGVVYEDIILDNVKNPIVIDQHYHSKNRNEPSRVKLVDIHFRNIRGTTTSKIPVLLNCSEALPCEGVELVDIDLAPVGSIGPLLPATCQNAKTILNGKNNPPAC,positive +GCAAUGGUACGGUACUUCCAAGUGCGGGGGGGAGGUGGUGGUUCCAAAAGUGCACGCUACUUUGCUAA,MARVRGPRLPGCLALAALFSLVHSQHVFLAHQQASSLLQRARRANKGFLEEVRKGNLERECLEEPCSREEAFEALESLSATDAFWAKYTACESARNPREKLNECLEGNCAEGVGMNYRGNVSVTRSGIECQLWRSRYPHKPEINSTTHPGADLRENFCRNPDGSITGPWCYTTSPTLRREECSVPVCGQDRVTVEVIPRSGGSTTSQSPLLETCVPDRGREYRGRLAVTTSGSRCLAWSSEQAKALSKDQDFNPAVPLAENFCRNPDGDEEGAWCYVADQPGDFEYCDLNYCEEPVDGDLGDRLGEDPDPDAAIEGRTSEDHFQPFFNEKTFGAGEADCGLRPLFEKKQVQDQTEKELFESYIEGRIVEGQDAEVGLSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTVDDLLVRIGKHSRTRYERKVEKISMLDKIYIHPRYNWKENLDRDIALLKLKRPIELSDYIHPVCLPDKQTAAKLLHAGFKGRVTGWGNRRETWTTSVAEVQPSVLQVVNLPLVERPVCKASTRIRITDNMFCAGYKPGEGKRGDACEGDSGGPFVMKSPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDRLGS,positive +CTCCTCTGACTGTAACCACGGACTGCTGATGAGTCACTTTAACGTGGAGCAAAGATTAAAGCATAGGTAGTCCAGAAGCC,MLDLFADAEPWQEPLAAGAVILRRFAFNAAEQLIRDINDVASQSPFRQMVTPGGYTMSVAMTNCGHLGWTTHRQGYLYSPIDPQTNKPWPAMPQSFHNLCQRAATAAGYPDFQPDACLINRYAPGAKLSLHQDKDEPDLRAPIVSVSLGLPAIFQFGGLKRNDPLKRLLLEHGDVVVWGGESRLFYHGIQPLKAGFHPLTIDCRYNLTFRQAGKKE,positive +UCAAUCGGCGCUUUACUCUUGCGCUCACCGUGCCC,IMEIRTVAVGIVAIKGVESEYYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHSGGEMFVALNQKGLPVKGKKTKKEQKTAHFLPMAIT,positive +CTTCTGCCCGCCTCCTTCCCTAGTGCAGGGGTTCACTCAGGACCTTACGAGCTTTTTCGGAGACGAGATAGGCGGACACT,MEGMLKGEGPGPLPPLLQQYVELRDQYPDYLLLFQVGDFYECFGEDAERLARALGLVLTHKTSKDFTTPMAGIPLRAFEAYAERLLKMGFRLAVADQVEPAEEAEGLVRREVTQLLTPGTLLQESLLPREANYLAAIATGDGWGLAFLDVSTGEFKGTVLKSKSALYDELFRHRPAEVLLAPELLENGAFLDEFRKRFPVMLSEAPFEPEGEGPLALRRARGALLAYAQRTQGGALSLQPFRFYDPGAFMRLPEATLRALEVFEPLRGQDTLFSVLDETRTAPGRRLLQSWLRHPLLDRGPLEARLDRVEGFVREGALREGVRRLLYRLADLERLATRLELGRASPKDLGALRRSLQILPELRALLGEEVGLPDLSPLKEELEAALVEDPPLKVSEGGLIREGYDPDLDALRAAHREGVAYFLELEERERERTGIPTLKVGYNAVFGYYLEVTRPYYERVPKEYRPVQTLKDRQRYTLPEMKEKEREVYRLEALIRRREEEVFLEVRERAKRQAEALREAARILAELDVYAALAEVAVRYGYVRPRFGDRLQIRAGRHPVVERRTEFVPNDLEMAHELVLITGPNMAGKSTFLRQTALIALLAQVGSFVPAEEAHLPLFDGIYTRIGASDDLAGGKSTFMVEMEEVALILKEATENSLVLLDEVGRGTSSLDGVAIATAVAEALHERRAYTLFATHYFELTALGLPRLKNLHVAAREEAGGLVFYHQVLPGPASKSYGVEVAAMAGLPKEVVARARALLQAMAARREGALDAVLERLLALDPDRLTPLEALRLLQELKALALGAPLDTMKG,positive +GCGACTCCTGTACTCGAAGACAGACAGTTCCAGCCTCCAG,MAIPKELLVLLLGIAILSKVAECAAFGSRRGLVETVFDVTRFGARPNTPADSTRGLMMAWRSACQSPGPAKVVIPPGTYTTGETIFQGPCTSPRPITIEIQGTLLSNTDMSLYTRAAWISIEHVDGIVITGGGTLNGQGKSSWQFADKSGSTPPLPSSLVFQTVRSSSIKNLNFVDAKGVHLKITDSSDISVSNIKITAPGDSPNTDGLHISDTINVNVTDSTIGTGDDCISIGDGNSNVYISNINCGPGHGISIGSLGKRLDETDVKGVTVRNCTFRGTTNGARIKTYMGSPSLQVSGVVYEDIILDNVKNPIVIDQHYHSKNRNEPSRVKLVDIHFRNIRGTTTSKIPVLLNCSEALPCEGVELVDIDLAPVGSIGPLLPATCQNAKTILNGKNNPPAC,positive +CTTCTGCCCGCCTCCTTCCTTTTTGCTGATCTCGGGTTTGGACTCCTGTTTATTTATAAGGAGACGAGATAGGCGGACACT,MGVHECPAWLWLLLSLLSLPLGLPVLGAPPRLICDSRVLERYLLEAKEAENITTGCAEHCSLNENITVPDTKVNFYAWKRMEVGQQAVEVWQGLALLSEAVLRGQALLVNSSQPWEPLQLHVDKAVSGLRSLTTLLRALGAQKEAISPPDAASAAPLRTITADTFRKLFRVYSNFLRGKLKLYTGEACRTGDR,positive +ATACCAGCTTATTCAATTACAGTAGTGAGGGGTCCGTCGTGGGGTAGTTGGGTCGTGGAGATAGTAAGTGCAATCT,ERDCRVSSFRVKENFDKARFAGTWYAMAKKDPEGLFLQDNIVAEFSVDENGHMSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGNDDHWIIDTDYETFAVQYSCRLLNLDGTCADSYSFVFARDPSGFSPEVQKIVRQRQEELCLARQYRLIPHNGYCDGKSERNIL,positive +GGUAGAUACGAUGGACUACCGCCACCCCGGGUCCGGGUGACGUUAAUUGAGGGCCCAUGACGCGCAGCCA,MRQTLPCIYFWGGLLPFGMLCASSTTKCTVSHEVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQALKSEELDIFANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFNPFDCTCESIAWFVNWINETHTNIPELSSHYLCNTPPHYHGFPVRLFDTSSCKDSAPFELFFMINTSILLIFIFIVLLIHFEGWRISFYWNVSVHRVLGFKEIDRQTEQFEYAAYIIHAYKDKDWVWEHFSSMEKEDQSLKFCLEERDFEAGVFELEAIVNSIKRSRKIIFVITHHLLKDPLCKRFKVHHAVQQAIEQNLDSIILVFLEEIPDYKLNHALCLRRGMFKSHCILNWPVQKERIGAFRHKLQVALGSKNSVH,positive +ACTCCATTCGTCTCGCGAGCGCAGTGACTCTGGACATTAT,MPSNQEARLFLAVLVLAQVLPILVDSAAEKGFKQAFWQPLCQVSEELDDQPKGALFTLQAAASKIQKMRDAALRASIYAEINHGTNRAKAAVIVANHYAMKADSGLEALKQTLSSQEVTATATASYLKGRIDEYLNLLLQTKESGTSGCMMDTSGTNTVTKAGGTIGGVPCKLQLSPIQPKRPAATYLGKAGYVGLTRQADAANNFHDNDAECRLASGHNTNGLGKSGQLSAAVTMAAGYVTVANSQTAVTVQALDALQEASGAAHQPWIDAWKAKKALTGAETAEFRNETAGIAGKTGVTKLVEEALLKKKDSEASEIQTELKKYFSGHENEQWTAIEKLISEQPVAQNLVGDNQPTKLGELEGNAKLTTILAYYRMETAGKFEVLTQKHKPAESQQQAAETEGSCNKKDQNECKSPCKWHNDAENKKCTLDKEEAKKVADETAKDGKTGNTNTTGSSNSFVISKTPLWLAVLLF,positive +GGGCCAGGCAGCGAGAGAUAAGCAGAAGAAGUAUGUGACCAUGCUCCAGAGAGCAACUUCACAUGCGUAGCCAAACCGACCACACGCGUCCGAGA,MTSHYVIAIFALMSSCLATAGPEPGALCELSPVSASHPVQALMESFTVLSGCASRGTTGLPQEVHVLNLRTAGQGPGQLQREVTLHLNPISSVHIHHKSVVFLLNSPHPLVWHLKTERLATGVSRLFLVSEGSVVQFSSANFSLTAETEERNFPHGNEHLLNWARKEYGAVTSFTELKIARNIYIKVGEDQVFPPKCNIGKNFLSLNYLAEYLQPKAAEGCVMSSQPQNEEVHIIELITPNSNPYSAFQVDITIDIRPSQEDLEVVKNLILILKCKKSVNWVIKSFDVKGSLKIIAPNSIGFGKESERSMTMTKSIRDDIPSTQGNLVKWALDNGYSPITSYTMAPVANRFHLRLENNAEEMGDEEVHTIPPELRILLDPGALPALQNPPIRGGEGQNGGLPFPFPDISRRVWNEEGEDGLPRPKDPVIPSIQLFPGLREPEEVQGSVDIALSVKCDNEKMIVAVEKDSFQASGYSGMDVTLLDPTCKAKMNGTHFVLESPLNGCGTRPRWSALDGVVYYNSIVIQVPALGDSSGWPDGYEDLESGDNGFPGDMDEGDASLFTRPEIVVFNCSLQQVRNPSSFQEQPHGNITFNMELYNTDLFLVPSQGVFSVPENGHVYVEVSVTKAEQELGFAIQTCFISPYSNPDRMSHYTIIENICPKDESVKFYSPKRVHFPIPQADMDKKRFSFVFKPVFNTSLLFLQCELTLCTKMEKHPQKLPKCVPPDEACTSLDASIIWAMMQNKKTFTKPLAVIHHEAESKEKGPSMKEPNPISPPIFHGLDTLTVMGIAFAAFVIGALLTGALWYIYSHTGETAGRQQVPTSPPASENSSAAHSIGSTQSTPCSSSSTA,positive +GGGACACAAUGGACGAAGUCAGUCGCAUUGGCCGAGCUGUCGCUCUGACCAACUGAUAACGGCCGACAUGAGAG,PHITDVVLDKANKTPLRQLDPSRLPDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFAKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRQSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPINRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDTASEATRPATLNRFSALQQTLPAENTDNRRVVQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRTRTPATKRSFSKEVEERSRERPSQPEGLRKAASLTEDRGRDPVKREATLPPVSPPKAALSVDEVEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRLGIESTLERSTIAREHMGRLLHQLLCAGHLSTAQYYQGLYETLELAEDMEIDIPHVWLYLAELITPILQEDGVPMGELFREITKPLRPMGKATSLLLEILGLLCKSMGPKKVGMLWREAGLSWREFLAEGQDVGSFVAEKKVEYTLGEESEAPGQRTLAFEELRRQLEKLLKDGGSNQRVFDWIDANLNEQQIASNTLVRALMTTVCYSAIIFETPLRVDVQVLKVRARLLQKYLCDEQKELQALYALQALVVTLEQPANLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFNWLREAEDEESDHN,positive +CGUAUUCAUCAGGUAGCGUAGAUCCGUGUGGCGGGCUGUUCCAUUUUA,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,positive +ACCCACCUACACCCCUCACCACACUACCAC,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,positive +TTCCGGCTATGGTTAAACAAAAGACTAGGGAGGTTATTCA,MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQRGLKNVFDEAILAALEPPETQPKRKCCIF,positive +CACGGTAGTGCTACCAGATGGTTATGTTACTTCAATTCTG,MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH,positive +TACGACCAATACGCCCAATACTGCTCCGACTGCTGCATTATCCAC,MKTLLLLLLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAKEPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHSRFQPSQSSTYSQPGQSFSIQYGTGSLSGIIGADQVSAFATQVEGLTVVGQQFGESVTEPGQTFVDAEFDGILGLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSHFSGSLNWVPVTKQAYWQIALDNIQVGGTVMFCSEGCQAIVDTGTSLITGPSDKIKQLQNAIGAAPVDGEYAVECANLNVMPDVTFTINGVPYTLSPTAYTLLDFVDGMQFCSSGFQGLDIHPPAGPLWILGDVFIRQFYSVFDRGNNRVGLAPAVP,positive +CTTCTGCCCGCCTCCTTCCCGCACTTGCAAACCTTCATGGTCTCGTGCTTGAGTGGTTGGAGACGAGATAGGCGGACACT,MEGMLKGEGPGPLPPLLQQYVELRDQYPDYLLLFQVGDFYECFGEDAERLARALGLVLTHKTSKDFTTPMAGIPLRAFEAYAERLLKMGFRLAVADQVEPAEEAEGLVRREVTQLLTPGTLLQESLLPREANYLAAIATGDGWGLAFLDVSTGEFKGTVLKSKSALYDELFRHRPAEVLLAPELLENGAFLDEFRKRFPVMLSEAPFEPEGEGPLALRRARGALLAYAQRTQGGALSLQPFRFYDPGAFMRLPEATLRALEVFEPLRGQDTLFSVLDETRTAPGRRLLQSWLRHPLLDRGPLEARLDRVEGFVREGALREGVRRLLYRLADLERLATRLELGRASPKDLGALRRSLQILPELRALLGEEVGLPDLSPLKEELEAALVEDPPLKVSEGGLIREGYDPDLDALRAAHREGVAYFLELEERERERTGIPTLKVGYNAVFGYYLEVTRPYYERVPKEYRPVQTLKDRQRYTLPEMKEKEREVYRLEALIRRREEEVFLEVRERAKRQAEALREAARILAELDVYAALAEVAVRYGYVRPRFGDRLQIRAGRHPVVERRTEFVPNDLEMAHELVLITGPNMAGKSTFLRQTALIALLAQVGSFVPAEEAHLPLFDGIYTRIGASDDLAGGKSTFMVEMEEVALILKEATENSLVLLDEVGRGTSSLDGVAIATAVAEALHERRAYTLFATHYFELTALGLPRLKNLHVAAREEAGGLVFYHQVLPGPASKSYGVEVAAMAGLPKEVVARARALLQAMAARREGALDAVLERLLALDPDRLTPLEALRLLQELKALALGAPLDTMKG,positive +CGGTCGCTCCGTGTGGCTTGGGTTGGGTGTGGCAGTGAC,MSWLLFLAHRVALAALPCRRGSRGFGMFYAVRRGRKTGVFLTWNECRAQVDRFPAARFKKFATEDEAWAFVRKSASPEVSEGHENQHGQESEAKASKRLREPLDGDGHESAEPYAKHMKPSVEPAPPVSRDTFSYMGDFVVVYTDGCCSSNGRRRPRAGIGVYWGPGHPLNVGIRLPGRQTNQRAEIHAACKAIEQAKTQNINKLVLYTDSMFTINGITNWVQGWKKNGWKTSAGKEVINKEDFVALERLTQGMDIQWMHVPGHSGFIGNEEADRLAREGAKQSED,positive +GGGAGAGGAGGGAGAUAGAUAUCAAAGCAUAGAUAGGAAUGGCGGCAAGUCACGAACGGUACUGGAACGCACAAGGAGUUUCGUGGAUGCCACAGGAC,WPLTEEKIKALVEICXEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEEFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDXIIYQYMDDLYVGSDLEIGQHRTKVEELRQHLLXWGFTTPDKKHQKEPPFLWMGYELHP,positive +AUCGGUCUGAACCGGCCCAGCAGACUGCGACGGCACGAU,MGVLLTQRTLLSLVLALLFPSMASMAAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQGLDVPKLREHCRERPGAFPSEETLRGLGRRGFLQTLNATLGCVLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILGLRNNIYCMAQLLDNSDTAEPTKAGRGASQPPTPTPASDAFQRKLEGCRFLHGYHRFMHSVGRVFSKWGESPNRSRRHSPHQALRKGVRRTRPSRKGKRLMTRGQLPR,positive +CTTCTGCCCGCCTCCTTCCCGGGTCATATGGGAACGCTACAGTGTTTCACGCTGAGTTGGAGACGAGATAGGCGGACACT,MEGMLKGEGPGPLPPLLQQYVELRDQYPDYLLLFQVGDFYECFGEDAERLARALGLVLTHKTSKDFTTPMAGIPLRAFEAYAERLLKMGFRLAVADQVEPAEEAEGLVRREVTQLLTPGTLLQESLLPREANYLAAIATGDGWGLAFLDVSTGEFKGTVLKSKSALYDELFRHRPAEVLLAPELLENGAFLDEFRKRFPVMLSEAPFEPEGEGPLALRRARGALLAYAQRTQGGALSLQPFRFYDPGAFMRLPEATLRALEVFEPLRGQDTLFSVLDETRTAPGRRLLQSWLRHPLLDRGPLEARLDRVEGFVREGALREGVRRLLYRLADLERLATRLELGRASPKDLGALRRSLQILPELRALLGEEVGLPDLSPLKEELEAALVEDPPLKVSEGGLIREGYDPDLDALRAAHREGVAYFLELEERERERTGIPTLKVGYNAVFGYYLEVTRPYYERVPKEYRPVQTLKDRQRYTLPEMKEKEREVYRLEALIRRREEEVFLEVRERAKRQAEALREAARILAELDVYAALAEVAVRYGYVRPRFGDRLQIRAGRHPVVERRTEFVPNDLEMAHELVLITGPNMAGKSTFLRQTALIALLAQVGSFVPAEEAHLPLFDGIYTRIGASDDLAGGKSTFMVEMEEVALILKEATENSLVLLDEVGRGTSSLDGVAIATAVAEALHERRAYTLFATHYFELTALGLPRLKNLHVAAREEAGGLVFYHQVLPGPASKSYGVEVAAMAGLPKEVVARARALLQAMAARREGALDAVLERLLALDPDRLTPLEALRLLQELKALALGAPLDTMKG,positive +CCCCGGAACCTTTCCCTAGCCGAAACAGCCC,MHGDTPTLHEYMLDLQPETTDLYCYEQLNDSSEEEDEIDGPAGQAEPDRAHYNIVTFCCKCDSTLRLCVQSTHVDIRTLEDLLMGTLGIVCPICSQKP,positive +GAAGCUUUCACACAACAAGGCCCGGGACUGUAUUAGGGAAAUUAGAGUACAGACAGUCGCCGUGGGUCGAAUUCCGCUCA,XQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGSTGSPGPGYGYSNYGFPPYGGITFHPGVTKSNAGVTHGTINTKFKNGPKDCAKSDDEESLTLPEKETEGEGPSLPMACTKTEPIALASTMEDKEQDMGFQDNLFLEKALQLARRHANALFDYAVTGDVKMLLAVQRHLTAVQDENGDSVLHLAIIHLHAQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRVGADLSLLDRWGNSVLHLAAKEGHDRILSILLKSRKAAPLIDHPNGEGLNAIHIAVMSNSLPCLLLLVAAGAEVNAQEQKSGRTALHLAVEYDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWEKAGEDEGVVPGTTPLDMAANWQVFDILNGKPYEPVFTSDDILPQGDMKQLTEDTRLQLCKLLEIPDPDKNWATLAQKLGLGILNNAFRLSPAPSKTLMDNYEMNSGIVTASVTVVWRHPSANSALQSLLLETAHCYL,positive +GGGCGAAUUCGAGCCUCAAGACGUCGGGGAUUGGCAAACCCCGUUUCCUUGAGCGACCCCCUGUUACUCGGCGGAUCCUCU,MVKSHIGSWILVLFVAMWSDVGLCKKRPKPGGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGSHSQWNKPSKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGNDYEDRYYRENMYRYPNQVYYRPVDRYSNQNNFVHDCVNITVKQHTVTTTTKGENFTETDIKIMERVVEQMCITQYQRESQAYYQRGASVILFSSPPVILLISFLIFLIVG,positive +CTTCTGCCCGCCTCCTTCCGATTGAAAGGTCTGTTTTTGGGGTTGGTTTGGGTCAATAGGAGACGAGATAGGCGGACACT,MGVHECPAWLWLLLSLLSLPLGLPVLGAPPRLICDSRVLERYLLEAKEAENITTGCAEHCSLNENITVPDTKVNFYAWKRMEVGQQAVEVWQGLALLSEAVLRGQALLVNSSQPWEPLQLHVDKAVSGLRSLTTLLRALGAQKEAISPPDAASAAPLRTITADTFRKLFRVYSNFLRGKLKLYTGEACRTGDR,positive +GGGTAACCTTGAGTCACGAATTCAAGCGGGACAGGAGAAACACGGCATGTCAGCGAAGGTACCCAACTTACAGCTTCT,MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINYDEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQAVAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQGIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADMDFSALLSQISS,positive +AAAGAGGAUUUGUGUUUUUCAGGAC,MNRNCASPEEGGTTEQLVKEASDIVERDGFENKKKPPTLKLEHVEVVGEKSPTPATVYDLFKKYKKPDIVTNSNGDDMNVGFDQLSSDEKNGFLRKLQMLTVSSRKSVKVVGESTPSSAGRLLKKFAPSRKPTEKISVDEPPSRFNFFGRSTKKLSDSDRPSSLPKKKSARRLLFGKEEQKPEPEVVKNRVLPAMTSQQSAKGAPIPINKPYRYQGPRGSLETPTDSPAKISSNSSSSSPIPPVPTRNHFTSMNEESPSKKRTFSRQGLSNRDNLSNGSWHGELPPRDYTSPTFSRKIFVGGVPWDITEAALKDSFGEFGSCAVEWPGQEARYRSGQSNIAPLTNLRNQSKYAGQAATGYVYMIFEDERAVASLLHECSQEIGGAGEWYFKIRAQRSKSTEIRQVQIIPWVTSDSMFCEDESLLETGIEPKRTVFVGALHGMMTAQVLHWIMEDCFGSVECVQLDTDKFKYPIGSGRVTFREHGAYFKAIEMGYLHVHTSKFRKRVQIDPFLESTSCMVCTTESAQCFCRNRNCFKYYCHTCWAIDHGKDNADDVHVPVIVPSSASKAYAGPHRRPHLTSNSLSKSHGCSTNNQLSHVLSPGFPMIVGGPSQTLSALYGYIQNNQQMMLTPAVYETPMTPPSNESNAKRRSFTEFQNPAIFFNPSSMMTPQKSATCSETPVPAFFTNSAAFLTPNSNYYGSPNHSSSNISQSPQQYYGANLYYGYMPPQVAYDGSTNGSKLSPIHVPHIPNYQ,positive +ATCAACTCACCGTAGGTCTAGTGAGAACTTCAAGTCTACT,MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP,positive +CTTCTGCCCGCCTCCTTCCTGGTAAAGTCATTAATAGGTGTGGGGTGCCGGGCATTTCGGAGACGAGATAGGCGGACACT,MEGMLKGEGPGPLPPLLQQYVELRDQYPDYLLLFQVGDFYECFGEDAERLARALGLVLTHKTSKDFTTPMAGIPLRAFEAYAERLLKMGFRLAVADQVEPAEEAEGLVRREVTQLLTPGTLLQESLLPREANYLAAIATGDGWGLAFLDVSTGEFKGTVLKSKSALYDELFRHRPAEVLLAPELLENGAFLDEFRKRFPVMLSEAPFEPEGEGPLALRRARGALLAYAQRTQGGALSLQPFRFYDPGAFMRLPEATLRALEVFEPLRGQDTLFSVLDETRTAPGRRLLQSWLRHPLLDRGPLEARLDRVEGFVREGALREGVRRLLYRLADLERLATRLELGRASPKDLGALRRSLQILPELRALLGEEVGLPDLSPLKEELEAALVEDPPLKVSEGGLIREGYDPDLDALRAAHREGVAYFLELEERERERTGIPTLKVGYNAVFGYYLEVTRPYYERVPKEYRPVQTLKDRQRYTLPEMKEKEREVYRLEALIRRREEEVFLEVRERAKRQAEALREAARILAELDVYAALAEVAVRYGYVRPRFGDRLQIRAGRHPVVERRTEFVPNDLEMAHELVLITGPNMAGKSTFLRQTALIALLAQVGSFVPAEEAHLPLFDGIYTRIGASDDLAGGKSTFMVEMEEVALILKEATENSLVLLDEVGRGTSSLDGVAIATAVAEALHERRAYTLFATHYFELTALGLPRLKNLHVAAREEAGGLVFYHQVLPGPASKSYGVEVAAMAGLPKEVVARARALLQAMAARREGALDAVLERLLALDPDRLTPLEALRLLQELKALALGAPLDTMKG,positive +GGGUUCGCUAAGUUGGUCUACCCCUCUCGAAUAUCCGUUA,MEDDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKEEIAEVANEIESLGSTEERKNMQRNKQVAMGRKKFNMDPKKGIQFLIENGLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERDEFSIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNTGVFQSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIKNEPFKIPVWFFLQNLYESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEDWIKCIKAAISRDPFYEMLAARKKKVSSTKRH,positive +TCCCTACGGCGCTAACGACGGGGGAGTTGTGCTCCCGAAAGGAGGTGCCACCGTGCTACAAC,VENLMVQELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFSHFRLFDENNDAAILILLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVN,positive +TAATACGACTCACTATAGGGAGACCCAAGCCGATTTATTTTGTGCAGCTTTTGTTCCCTTTAGTGAGGGTTAATT,MHGDTPTLHEYMLDLQPETTDLYCYEQLNDSSEEEDEIDGPAGQAEPDRAHYNIVTFCCKCDSTLRLCVQSTHVDIRTLEDLLMGTLGIVCPICSQKP,positive +GAUGUUUCGAAUGUUGCGGGUGAGACACAGCAUGACAAACUACCGUGUCA,MSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEMLDRHHTHFCPLEGESWQDFLRNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAFLCQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERETPTTDSMPPLLRQAIELFDHQGAEPAFLFGLELIICGLEKQLKCESGS,positive +AGCAGCACAGAGGTCAGATGGGTAGGTAGCCGTGCCGGTTGTGCCATTGATTGTACAGTTCCTATGCGTGCTACCGTGAA,MLSWGYFLFLLPTLPGAQSQVQLVESGGDVRKPGDSLRLSCKGSGFTFSNYWLGWVRQAPGKALNGSLPLTPLAAAPTYIPGVSGRFTISRDNARALLHLDMSDLRPEDTGRYHCER,positive +TCCCCGGAACCTTTCCCTAGCCGAAACAGCCC,MHGDTPTLHEYMLDLQPETTDLYCYEQLNDSSEEEDEIDGPAGQAEPDRAHYNIVTFCCKCDSTLRLCVQSTHVDIRTLEDLLMGTLGIVCPICSQKP,positive +CTTCTGCCCGCCTCCTTCCGTGGGGATGCCATTGGTCCACAGGGTTATGGGAGCATCAGGAGACGAGATAGGCGGACACT,MEGMLKGEGPGPLPPLLQQYVELRDQYPDYLLLFQVGDFYECFGEDAERLARALGLVLTHKTSKDFTTPMAGIPLRAFEAYAERLLKMGFRLAVADQVEPAEEAEGLVRREVTQLLTPGTLLQESLLPREANYLAAIATGDGWGLAFLDVSTGEFKGTVLKSKSALYDELFRHRPAEVLLAPELLENGAFLDEFRKRFPVMLSEAPFEPEGEGPLALRRARGALLAYAQRTQGGALSLQPFRFYDPGAFMRLPEATLRALEVFEPLRGQDTLFSVLDETRTAPGRRLLQSWLRHPLLDRGPLEARLDRVEGFVREGALREGVRRLLYRLADLERLATRLELGRASPKDLGALRRSLQILPELRALLGEEVGLPDLSPLKEELEAALVEDPPLKVSEGGLIREGYDPDLDALRAAHREGVAYFLELEERERERTGIPTLKVGYNAVFGYYLEVTRPYYERVPKEYRPVQTLKDRQRYTLPEMKEKEREVYRLEALIRRREEEVFLEVRERAKRQAEALREAARILAELDVYAALAEVAVRYGYVRPRFGDRLQIRAGRHPVVERRTEFVPNDLEMAHELVLITGPNMAGKSTFLRQTALIALLAQVGSFVPAEEAHLPLFDGIYTRIGASDDLAGGKSTFMVEMEEVALILKEATENSLVLLDEVGRGTSSLDGVAIATAVAEALHERRAYTLFATHYFELTALGLPRLKNLHVAAREEAGGLVFYHQVLPGPASKSYGVEVAAMAGLPKEVVARARALLQAMAARREGALDAVLERLLALDPDRLTPLEALRLLQELKALALGAPLDTMKG,positive +GGGAGCTCAGAATAAACGCTCAAAATGCGGGGTGGGTGGGGTGGTTGAAGAATATTCGACATGAGGCCCGGATC,MLNQLDNLTERVRGSNKLVDRWLHVRKHLLVAYYNLVGIKPGKESYMRLNEKALDDFCQSLVDYLSAGHFSIYERILHKLEGNGQLARAAKIWPQLEANTQQIMDYYDSSLETAIDHDNYLEFQQVLSDIGEALEARFVLEDKLILLVLDAARVKHPA,positive +CUUGCCGUAGACCCAUUUUCCAAUCACAAGUCACGCGUCUCAAGCUGUUA,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,positive +CTCCTCTGACTGTAACCACGCCCATAGCGGTGAATGCATGAGCAACCCGATTGACACGGGGCATAGGTAGTCCAGAAGCC,MLDLFADAEPWQEPLAAGAVILRRFAFNAAEQLIRDINDVASQSPFRQMVTPGGYTMSVAMTNCGHLGWTTHRQGYLYSPIDPQTNKPWPAMPQSFHNLCQRAATAAGYPDFQPDACLINRYAPGAKLSLHQDKDEPDLRAPIVSVSLGLPAIFQFGGLKRNDPLKRLLLEHGDVVVWGGESRLFYHGIQPLKAGFHPLTIDCRYNLTFRQAGKKE,positive +CTTCTGCCCGCCTCCTTCCGTCTTATGTCGTTAGTCGCAGGGTGATGAGTGAGGCAAGGGAGACGAGATAGGCGGACACT,MEGMLKGEGPGPLPPLLQQYVELRDQYPDYLLLFQVGDFYECFGEDAERLARALGLVLTHKTSKDFTTPMAGIPLRAFEAYAERLLKMGFRLAVADQVEPAEEAEGLVRREVTQLLTPGTLLQESLLPREANYLAAIATGDGWGLAFLDVSTGEFKGTVLKSKSALYDELFRHRPAEVLLAPELLENGAFLDEFRKRFPVMLSEAPFEPEGEGPLALRRARGALLAYAQRTQGGALSLQPFRFYDPGAFMRLPEATLRALEVFEPLRGQDTLFSVLDETRTAPGRRLLQSWLRHPLLDRGPLEARLDRVEGFVREGALREGVRRLLYRLADLERLATRLELGRASPKDLGALRRSLQILPELRALLGEEVGLPDLSPLKEELEAALVEDPPLKVSEGGLIREGYDPDLDALRAAHREGVAYFLELEERERERTGIPTLKVGYNAVFGYYLEVTRPYYERVPKEYRPVQTLKDRQRYTLPEMKEKEREVYRLEALIRRREEEVFLEVRERAKRQAEALREAARILAELDVYAALAEVAVRYGYVRPRFGDRLQIRAGRHPVVERRTEFVPNDLEMAHELVLITGPNMAGKSTFLRQTALIALLAQVGSFVPAEEAHLPLFDGIYTRIGASDDLAGGKSTFMVEMEEVALILKEATENSLVLLDEVGRGTSSLDGVAIATAVAEALHERRAYTLFATHYFELTALGLPRLKNLHVAAREEAGGLVFYHQVLPGPASKSYGVEVAAMAGLPKEVVARARALLQAMAARREGALDAVLERLLALDPDRLTPLEALRLLQELKALALGAPLDTMKG,positive +CACUCGUACAUGUCCGUAGUUUUCCCACACUCCC,MAVAQELYGFPASKLDSFVAQWLQPTREWKEEVLETVQTVEQFLRQENFREDRGPARDVRVLKVLKVGCFGNGTVLRSTTDVELVVFLSCFHSFQEEAKHHQAVLRLIQKRMYYCQELMDLGLSNLSVTNRVPSSLIFTIQTRETWETITVTVVPAYRALGPSCPSSEVYANLIKANGYPGNFSPSFSELQRNFVKHRPTKLKSLLRLVKHWYQQYVRDKCPRANLPPLYALELLTVYAWEAGTREDANFRLDEGLATVMELLQDHELLCIYWTKHYTLQHPVIEACVRRQLRGQRPIILDPADPTNNVAEGYRWDIVAQRANQCLKQDCCYDNRDSPVPSWRVKRAPDIQVTVQEWGHSDLTFWVNPYEPIKKLKEKIQLSQGYLGLQRLSFQEPGGERQLIRSHCTLAYYGIFCDTHICLLDTISPEIQVFVKNPDGRSHAYAIHPLDYVLNLKQQIEDRQGLRCQEQRLEFQGHILEDWFDFKSYGIQDSVTVILSKTTEGAAPFVPS,positive +GGAAAAGATGGTATGGGCCCTAGAAAGTCCACCCGGCGCC,MAIPKELLVLLLGIAILSKVAECAAFGSRRGLVETVFDVTRFGARPNTPADSTRGLMMAWRSACQSPGPAKVVIPPGTYTTGETIFQGPCTSPRPITIEIQGTLLSNTDMSLYTRAAWISIEHVDGIVITGGGTLNGQGKSSWQFADKSGSTPPLPSSLVFQTVRSSSIKNLNFVDAKGVHLKITDSSDISVSNIKITAPGDSPNTDGLHISDTINVNVTDSTIGTGDDCISIGDGNSNVYISNINCGPGHGISIGSLGKRLDETDVKGVTVRNCTFRGTTNGARIKTYMGSPSLQVSGVVYEDIILDNVKNPIVIDQHYHSKNRNEPSRVKLVDIHFRNIRGTTTSKIPVLLNCSEALPCEGVELVDIDLAPVGSIGPLLPATCQNAKTILNGKNNPPAC,positive +CGGTCGAAATTCGACCCTGTGTG,GLVKKAHEISVLCDAELALIIFSPKGKLYEYATDSKMEIILERYERYTYAEKALIASDPDVQGNWCHEYIKLKAKFEALNKSQRHLMGEQLDTLNQKELLQLETKLEGSLKNVRSRKTQLMLDSISELQEKGKSLQEQNTCLEKEILGKQKDKAPKQHVQWEKQNQPPPTSSAPMPFLIGDIHPTPNIRNFQGRTVADA,positive +GACUAAACGCAUUGUGCCCC,QELLCAASLISDRWVLTAAHCLLYPPWDKNFTVNDILVRIGKYARSRYERNMEKISTLEKIIIHPGYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDKQIVTSLLQAGHKGRVTGWGNLKEMWTVNMNEVQPSVLQMVNLPLVERPICKASTGIRVTDNMFCAGYKPEEGKRGDACEGDSGGPFVMKNPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIRKMVDRFG,positive +GGGAGAGCGGAAGCGUGCUGGGCCGGAGUUGAGGCGUAGAUGGUUCAGAUCCGAACGAUGAAGCAUAACCCAGAGGUCGAUGGAUCC,MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM,positive +GGGGTTCCACCTTCACTGGGCGCGCCCAGTGAAGGTGGAACCCC,MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINYDEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQAVAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQGIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADMDFSALLSQISS,positive +GACGAGGCUAAAACAAUUGUGUUCCAGGAUUGCGGUACAGGCACCGCUGGGAGUACUACAAGCUUCUGGACUCGGU,MASTSRLDALPRVTCPNHPDAILVEDYRAGDMICPECDRVIDVGSEWRTFSNDKATKDPSRVGDSQNPLLSDGDLSTMIGKGTGAASFDEFGNSKYQNRRTMSSSDRAMMNAFKEITTMADRINLPRNIVDRTNNLFKQVYEQKSLKGRANDAIASACLYIACRQEGVPRTFKEICAVSRISKKEIGRCFKLILKALETSVDLITTGDFMSRFCSNLCLPKQVQMAATHIA,positive +UGGGGUAUCGCCAAAAGAAAGGCACCGGAUUCUGAUUCCGGAGGUCGAGAUUGUCGUCCUCGUACCCCAGCCA,MSEAEARPTNFIRQIIDEDLASGKHTTVHTRFPPEPNGYLHIGHAKSICLNFGIAQDYKGQCNLRFDDTNPVKEDIEYVESIKNDVEWLGFHWSGNVRYSSDYFDQLHAYAIELINKGLAYVDELTPEQIREYRGTLTQPGKNSPYRDRSVEENLALFEKMRAGGFEEGKACLRAKIDMASPFIVMRDPVLYRIKFAEHHQTGNKWCIYPMYDFTHCISDALEGITHSLCTLEFQDNRRLYDWVLDNITIPVHPRQYEFSRLNLEYTVMSKRKLNLLVTDKHVEGWDDPRMPTISGLRRRGYTAASIREFCKRIGVTKQDNTIEMASLESCIREDLNENAPRAMAVIDPVKLVIENYQGEGEMVTMPNHPNKPEMGSRQVPFSGEIWIDRADFREEANKQYKRLVLGKEVRLRNAYVIKAERVEKDAEGNITTIFCTYDADTLSKDPADGRKVKGVIHWVSAAHALPVEIRLYDRLFSVPNPGAADDFLSVINPESLVIKQGFAEPSLKDAVAGKAFQFEREGYFCLDSRHSTAEKPVFNRTVGLRDTWAKVGE,positive +GGTTGGTGTGGTTGG,ASFTCLAIWALASAGVVPLVLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAAFFFVPVIISTVCYVSIIRCLSSSAVANRSKK,positive +CACCAGACCGACAUCAGCUUAUGGCCCCUCACCCACACCG,MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYTFLLPEMDNCRSSSSPYVSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQDNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVLVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF,positive +UCGUGCCUUUUCUCGAUGGAGUGAGAAGAGGUGACGG,ASFTCLAIWALASAGVVPLVLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAAFFFVPVIISTVCYVSIIRCLSSSAVANRSKK,positive +CTTCTGCCCGCCTCCTTCCTCGGGGTTAGAACGTCGTGTAGGACTCCTATCGGTTTATGGAGACGAGATAGGCGGACACT,MEGMLKGEGPGPLPPLLQQYVELRDQYPDYLLLFQVGDFYECFGEDAERLARALGLVLTHKTSKDFTTPMAGIPLRAFEAYAERLLKMGFRLAVADQVEPAEEAEGLVRREVTQLLTPGTLLQESLLPREANYLAAIATGDGWGLAFLDVSTGEFKGTVLKSKSALYDELFRHRPAEVLLAPELLENGAFLDEFRKRFPVMLSEAPFEPEGEGPLALRRARGALLAYAQRTQGGALSLQPFRFYDPGAFMRLPEATLRALEVFEPLRGQDTLFSVLDETRTAPGRRLLQSWLRHPLLDRGPLEARLDRVEGFVREGALREGVRRLLYRLADLERLATRLELGRASPKDLGALRRSLQILPELRALLGEEVGLPDLSPLKEELEAALVEDPPLKVSEGGLIREGYDPDLDALRAAHREGVAYFLELEERERERTGIPTLKVGYNAVFGYYLEVTRPYYERVPKEYRPVQTLKDRQRYTLPEMKEKEREVYRLEALIRRREEEVFLEVRERAKRQAEALREAARILAELDVYAALAEVAVRYGYVRPRFGDRLQIRAGRHPVVERRTEFVPNDLEMAHELVLITGPNMAGKSTFLRQTALIALLAQVGSFVPAEEAHLPLFDGIYTRIGASDDLAGGKSTFMVEMEEVALILKEATENSLVLLDEVGRGTSSLDGVAIATAVAEALHERRAYTLFATHYFELTALGLPRLKNLHVAAREEAGGLVFYHQVLPGPASKSYGVEVAAMAGLPKEVVARARALLQAMAARREGALDAVLERLLALDPDRLTPLEALRLLQELKALALGAPLDTMKG,positive +GGAGUCUUAGGCAGCGCGUUUUCGAGCUACUCCA,MGCRRTREGPSKAMIFPWKCQSTQRDLWNIFKLWGWTMLCCDFLAHHGTDCWTYHYSEKPMNWQRARRFCRDNYTDLVAIQNKAEIEYLEKTLPFSRSYYWIGIRKIGGIWTWVGTNKSLTEEAENWGDGEPNNKKNKEDCVEIYIKRNKDAGKWNDDACHKLKAALCYTASCQPWSCSGHGECVEIINNYTCNCDVGYYGPQCQFVIQCEPLEAPELGTMDCTHPLGNFSFSSQCAFSCSEGTNLTGIEETTCGPFGNWSSPEPTCQVIQCEPLSAPDLGIMNCSHPLASFSFTSACTFICSEGTELIGKKKTICESSGIWSNPSPICQKLDKSFSMIKEGDYNPLFIPVAVMVTAFSGLAFIIWLARRLKKGM,positive +CTCCTCTGACTGTAACCACGAGAAATTGGTACTGTATGAAACGGCAGCTGCACGTCGCGGCATAGGTAGTCCAGAAGCC,MLDLFADAEPWQEPLAAGAVILRRFAFNAAEQLIRDINDVASQSPFRQMVTPGGYTMSVAMTNCGHLGWTTHRQGYLYSPIDPQTNKPWPAMPQSFHNLCQRAATAAGYPDFQPDACLINRYAPGAKLSLHQDKDEPDLRAPIVSVSLGLPAIFQFGGLKRNDPLKRLLLEHGDVVVWGGESRLFYHGIQPLKAGFHPLTIDCRYNLTFRQAGKKE,positive +CAUGUCUACAACAAUCUCGCCCGUUGAGUCUCGUCGAAUU,MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYTFLLPEMDNCRSSSSPYVSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQDNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVLVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF,positive +AGCGCGCACCTACTGTGATGCAGAAGTCACAGCAAGGCCC,MPSNQEARLFLAVLVLAQVLPILVDSAAEKGFKQAFWQPLCQVSEELDDQPKGALFTLQAAASKIQKMRDAALRASIYAEINHGTNRAKAAVIVANHYAMKADSGLEALKQTLSSQEVTATATASYLKGRIDEYLNLLLQTKESGTSGCMMDTSGTNTVTKAGGTIGGVPCKLQLSPIQPKRPAATYLGKAGYVGLTRQADAANNFHDNDAECRLASGHNTNGLGKSGQLSAAVTMAAGYVTVANSQTAVTVQALDALQEASGAAHQPWIDAWKAKKALTGAETAEFRNETAGIAGKTGVTKLVEEALLKKKDSEASEIQTELKKYFSGHENEQWTAIEKLISEQPVAQNLVGDNQPTKLGELEGNAKLTTILAYYRMETAGKFEVLTQKHKPAESQQQAAETEGSCNKKDQNECKSPCKWHNDAENKKCTLDKEEAKKVADETAKDGKTGNTNTTGSSNSFVISKTPLWLAVLLF,positive +AUAGCCUCCGAUCCGCUAACUCUAACCCGCCAACUCCU,MGVLLTQRTLLSLVLALLFPSMASMAAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQGLDVPKLREHCRERPGAFPSEETLRGLGRRGFLQTLNATLGCVLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILGLRNNIYCMAQLLDNSDTAEPTKAGRGASQPPTPTPASDAFQRKLEGCRFLHGYHRFMHSVGRVFSKWGESPNRSRRHSPHQALRKGVRRTRPSRKGKRLMTRGQLPR,positive +GGCTATAGCACATGGGTAAAACGAC,MTPDIQAPFLSLLLLFPVLTVANVPTLTTSDSINPRRTTPVSTTQSSPTSSPTKETSWSTTTTLLTASSPAPSPAASPGHDGASTPTSSPAPSPAASPGHDGASTPTSSPAPSPAASPGHDGASTPTSSPAPSPAASPGHDGASTPTSSPAPSPAASPGHNGTSSPTGSPAPSPAASPGHDGASTPTSSPAPSPAASPGHNGTSSPTGSPAPSPAASPGHDGASTPTSSPAPSPAASPGHNGTSSPTGSPAPSPTASPGHDSAPSLTSSPAPSPTASPGQHGASSPTSSDTSSMTTRSMSSSMVTSAHKGTSSRATMTPVSKGTPSSVPSSETAPTAASHITRTAASSPSIALSTSSNPKTSQQLSVRVSLYFLSFRITNLQFNSSLENPQTSYYQELQRSIWGLILQIYKQRDFLGLSEIKFRPGSVVVELTLAFREGTTAEWVKAQFSQLEAHAASYNLTISGVSVYSAPFPSSAQAGSGVPGWGIALLVLVCVLVALAIIYLIALVVCQCGRKKCEQLDVFPTLDAYHPMSEYSTYHTHGRYVPPGSTKRSPYEEVSAGNGGSNLSYTNLAATSANL,positive +TTATGGGGATGAAAGTGGTGTTCGGGTTCGCCACTTCCAC,MSMSPKHTTPFSVSDILSPLEESYKKVGMEGGGLGAPLAAYRQGQAAPPAAAMQQHAVGHHGAVTAAYHMTAAGVPQLSHSAVGGYCNGNLGNMSELPPYQDTMRNSASGPGWYGANPDPRFPAISRFMGPASGMNMSGMGGLGSLGDVSKNMAPLPSAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGGGGGGGAGCPQQQQAQQQSPRRVAVPVLVKDGKPCQAGAPAPGAGSLQGHAQQQAQQQAQAAQAAAAAISVGSGGPGLGAHPGHQPGSAGQSPDLAHHAASPAALQGQVSSLSHLNSSGSDYGTMSCSTLLYGRTW,positive +CCACCAGCCCAGAGAUAGCCCAGACACCACCAAGAC,MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICEVEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASSIVYKKEGEQVEFSFPLAFTVEKLTGSGELWWQAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLPQALPQYAGSGNLTLALEAKTGKLHQEVNLVVMRATQLQKNLTCEVWGPTSPKLMLSLKLENKEAKVSKREKAVWVLNPEAGMWQCLLSDSGQVLLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQAERMSQIKRLLSEKKTCQCPHRFQKTCSPI,positive +CAGCTCAGAAGCTTGATCCTGTGAAGGGCTGATGAGGGGCGTAGCGGCTTGTTCGTAAGACTCGAAGTCGTGCATCTGCA,QDRPIKFSTEGATSQSYKQFIEALRERLRGGLIHDIPVLPDPTTLQERNRYITVELSNSDTESIEVGIDVTNAYVVAYRAGTQSYFLRDAPSSASDYLFTGTDQHSLPFYGTYGDLERWAHQSRQQIPLGLQALTHGISFFRSGGNDNEEKARTLIVIIQMVAEAARFRYISNRVRVSIQTGTAFQPDAAMISLENNWDNLSRGVQESVQDTFPNQVTLTNIRNEPVIVDSLSHPTVAVLALMLFVCNPPNANQSPLLIRSIVEKSKICSSRYEPTVRIGGRDGMCVDVYDNGYHNGNRIIMWKCKDRLEENQLWTLKSDKTIRSNGKCLTTYGYAPGSYVMIYDCTSAVAEATYWEIWDNGTIINPKSALVLSAESSSMGGTLTVQTNEYLMRQGWRTGNNTSPFVTSISGYSDLCMQAQGSNVWMADCDSNKKEQQWALYTDGSIRSVQNTNNCLTSKDHKQGSTILLMGCSNGWASQRWVFKNDGSIYSLYDDMVMDVKGSDPSLKQIILWPYTGKPNQIWLTLF,positive +CTCCTCTGACTGTAACCACGCAGGCCAATAACTAGCAGGTTACTGTTCATCATTTCGCACGCATAGGTAGTCCAGAAGCC,MLDLFADAEPWQEPLAAGAVILRRFAFNAAEQLIRDINDVASQSPFRQMVTPGGYTMSVAMTNCGHLGWTTHRQGYLYSPIDPQTNKPWPAMPQSFHNLCQRAATAAGYPDFQPDACLINRYAPGAKLSLHQDKDEPDLRAPIVSVSLGLPAIFQFGGLKRNDPLKRLLLEHGDVVVWGGESRLFYHGIQPLKAGFHPLTIDCRYNLTFRQAGKKE,positive +CCAAGGGCUAAGUCCGCAAAUAUCCUUCCUAAAGGACUCGUUACGUCGG,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,positive +ACTACACGAGGACCTACGACTACTACATTATGCCAACCGGTCTTGCTTCGACACAGATACCTC,MKRASAGGSRLLAWVLWLQAWQVAAPCPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDNPWVCDCRARPLWAWLQKFRGSSSEVPCSLPQRLAGRDLKRLAANDLQGCAVATGPYHPIWTGRATDEEPLGLPKCCQPDAADKASVLEPGRPASAGNALKGRVPPGDSPPGNGSGPRHINDSPFGTLPGSAEPPLTAVRPEGSEPPGFPTSGPRRRPGCSRKNRTRSHCRLGQAGSGGGGTGDSEGSGALPSLTCSLTPLGLALVLWTVLGPC,positive +GAGCAUUAACAAAAAGAUCACUAGGAACAGCGGUA,MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICEVEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASSIVYKKEGEQVEFSFPLAFTVEKLTGSGELWWQAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLPQALPQYAGSGNLTLALEAKTGKLHQEVNLVVMRATQLQKNLTCEVWGPTSPKLMLSLKLENKEAKVSKREKAVWVLNPEAGMWQCLLSDSGQVLLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQAERMSQIKRLLSEKKTCQCPHRFQKTCSPI,positive +GGAGUCUUAGGCAGCGCGUUUUCGAGCUACUCCA,MGCRRTREGPSKAMIFPWKCQSTQRDLWNIFKLWGWTMLCCDFLAHHGTDCWTYHYSEKPMNWQRARRFCRDNYTDLVAIQNKAEIEYLEKTLPFSRSYYWIGIRKIGGIWTWVGTNKSLTEEAENWGDGEPNNKKNKEDCVEIYIKRNKDAGKWNDDACHKLKAALCYTASCQPWSCSGHGECVEIINNYTCNCDVGYYGPQCQFVIQCEPLEAPELGTMDCTHPLGNFSFSSQCAFSCSEGTNLTGIEETTCGPFGNWSSPEPTCQVIQCEPLSAPDLGIMNCSHPLASFSFTSACTFICSEGTELIGKKKTICESSGIWSNPSPICQKLDKSFSMIKEGDYNPLFIPVAVMVTAFSGLAFIIWLARRLKKGM,positive +GUACAACACAUCAUUACGGCUGCUAUUGGCUCCAAGCGUCUUUCUCCCUGGUCAAUAGUCCGCCACCACG,MSGGDGRGHNTGAHSTSGNINGGPTGLGVGGGASDGSGWSSENNPWGGGSGSGIHWGGGSGHGNGGGNGNSGGGSGTGGNLSAVAAPVAFGFPALSTPGAGGLAVSISAGALSAAIADIMAALKGPFKFGLWGVALYGVLPSQIAKDDPNMMSKIVTSLPADDITESPVSSLPLDKATVNVNVRVVDDVKDERQNISVVSGVPMSVPVVDAKPTERPGVFTASIPGAPVLNISVNNSTPAVQTLSPGVTNNTDKDVRPAGFTQGGNTRDAVIRFPKDSGHNAVYVSVSDVLSPDQVKQRQDEENRRQQEWDATHPVEAAERNYERARAELNQANEDVARNQERQAKAVQVYNSRKSELDAANKTLADAIAEIKQFNRFAHDPMAGGHRMWQMAGLKAQRAQTDVNNKQAAFDAAAKEKSDADAALSSAMESRKKKEDKKRSAENNLNDEKNKPRKGFKDYGHDYHPAPKTENIKGLGDLKPGIPKTPKQNGGGKRKRWTGDKGRKIYEWDSQHGELEGYRASDGQHLGSFDPKTGNQLKGPDPKRNIKKYL,positive +CTTCTGCCCGCCTCCTTCCAACGGGTACTGCCTATCAGACATGGAAACGGTGCCGTTGGGAGACGAGATAGGCGGACACT,MEGMLKGEGPGPLPPLLQQYVELRDQYPDYLLLFQVGDFYECFGEDAERLARALGLVLTHKTSKDFTTPMAGIPLRAFEAYAERLLKMGFRLAVADQVEPAEEAEGLVRREVTQLLTPGTLLQESLLPREANYLAAIATGDGWGLAFLDVSTGEFKGTVLKSKSALYDELFRHRPAEVLLAPELLENGAFLDEFRKRFPVMLSEAPFEPEGEGPLALRRARGALLAYAQRTQGGALSLQPFRFYDPGAFMRLPEATLRALEVFEPLRGQDTLFSVLDETRTAPGRRLLQSWLRHPLLDRGPLEARLDRVEGFVREGALREGVRRLLYRLADLERLATRLELGRASPKDLGALRRSLQILPELRALLGEEVGLPDLSPLKEELEAALVEDPPLKVSEGGLIREGYDPDLDALRAAHREGVAYFLELEERERERTGIPTLKVGYNAVFGYYLEVTRPYYERVPKEYRPVQTLKDRQRYTLPEMKEKEREVYRLEALIRRREEEVFLEVRERAKRQAEALREAARILAELDVYAALAEVAVRYGYVRPRFGDRLQIRAGRHPVVERRTEFVPNDLEMAHELVLITGPNMAGKSTFLRQTALIALLAQVGSFVPAEEAHLPLFDGIYTRIGASDDLAGGKSTFMVEMEEVALILKEATENSLVLLDEVGRGTSSLDGVAIATAVAEALHERRAYTLFATHYFELTALGLPRLKNLHVAAREEAGGLVFYHQVLPGPASKSYGVEVAAMAGLPKEVVARARALLQAMAARREGALDAVLERLLALDPDRLTPLEALRLLQELKALALGAPLDTMKG,positive +GUAAACCGAAGUACUAGACUUGACCUAACA,MAKGEFIRTKPHVNVGTIGHVDHGKTTLTAALTYVAAAENPNVEVKDYGDIDKAPEERARGITINTAHVEYETAKRHYSHVDCPGHADYIKNMITGAAQMDGAILVVSAADGPMPQTREHILLARQVGVPYIVVFMNKVDMVDDPELLDLVEMEVRDLLNQYEFPGDEVPVIRGSALLALEEMHKNPKTKRGENEWVDKIWELLDAIDEYIPTPVRDVDKPFLMPVEDVFTITGRGTVATGRIERGKVKVGDEVEIVGLAPETRKTVVTGVEMHRKTLQEGIAGDNVGLLLRGVSREEVERGQVLAKPGSITPHTKFEASVYILKKEEGGRHTGFFTGYRPQFYFRTTDVTGVVRLPQGVEMVMPGDNVTFTVELIKPVALEEGLRFAIREGGRTVGAGVVTKILE,positive +UCAUGGUGUCUUUCCACAGCUCUUCCCAUGAUCGCCCGG,IMEIRTVAVGIVAIKGVESEYYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHSGGEMFVALNQKGLPVKGKKTKKEQKTAHFLPMAIT,positive +TTGGGACGGTGTTAAACGAAAGGGGACGAC,MDKFWWHAAWGLCLVPLSLAQIDLNITCRFAGVFHVEKNGRYSISRTEAADLCKAFNSTLPTMAQMEKALSIGFETCRYGFIEGHVVIPRIHPNSICAANNTGVYILTSNTSQYDTYCFNASAPPEEDCTSVTDLPNAFDGPITITIVNRDGTRYVQKGEYRTNPEDIYPSNPTDDDVSSGSSSERSSTSGGYIFYTFSTVHPIPDEDSPWITDSTDRIPATTLMSTSATATETATKRQETWDWFSWLFLPSESKNHLHTTTQMAGTSSNTISAGWEPNEENEDERDRHLSFSGSGIDDDEDFISSTISTTPRAFDHTKQNQDWTQWNPSHSNPEVLLQTTTRMTDVDRNGTTAYEGNWNPEAHPPLIHHEHHEEEETPHSTSTIQATPSSTTEETATQKEQWFGNRWHEGYRQTPKEDSHSTTGTAAASAHTSHPMQGRTTPSPEDSSWTDFFNPISHPMGRGHQAGRRMDMDSSHSITLQPTANPNTGLVEDLDRTGPLSMTTQQSNSQSFSTSHEGLEEDKDHPTTSTLTSSNRNDVTGGRRDPNHSEGSTTLLEGYTSHYPHTKESRTFIPVTSAKTGSFGVTAVTVGDSNSNVNRSLSGDQDTFHPSGGSHTTHGSESDGHSHGSQEGGANTTSGPIRTPQIPEWLIILASLLALALILAVCIAVNSRRRCGQKKKLVINSGNGAVEDRKPSGLNGEASKSQEMVHLVNKESSETPDQFMTADETRNLQNVDMKIGV,positive +TGTGGGGGTGGACGGGCCGGGTAGA,MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPGPHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR,positive +GGGAGCTCAGAATAAACGCTCAAGGATGGGTGGGTGGGGAGGTTGTAGACTGTATTTCGACATGAGGCCCGGATC,MLNQLDNLTERVRGSNKLVDRWLHVRKHLLVAYYNLVGIKPGKESYMRLNEKALDDFCQSLVDYLSAGHFSIYERILHKLEGNGQLARAAKIWPQLEANTQQIMDYYDSSLETAIDHDNYLEFQQVLSDIGEALEARFVLEDKLILLVLDAARVKHPA,positive +AAAAAGGAGGAGGAGGA,MVKSHIGSWILVLFVAMWSDVGLCKKRPKPGGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGTHGQWNKPSKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGSDYEDRYYRENMHRYPNQVYYRPVDQYSNQNNFVHDCVNITVKEHTVTTTTKGENFTETDIKMMERVVEQMCITQYQRESQAYYQRGASVILFSSPPVILLISFLIFLIVG,positive +GCAUGCAGUGUCUAUUCUCGAGUAGCGAUCGUUGAAGGGGUAUAAGGUUGGCAGAUCGCUAGCAUGCAACUGACUCGGAUAAGCA,MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINYDEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQAVAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQGIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADMDFSALLSQISS,positive +GGUAGAUACGAUGGAGGUGUAUUUUAUGUGCGUAUUUGGAGGCAUGACGCGCAGCCA,MANLGYWLLALFVTMWTDVGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGTWGQPHGGGWGQPHGGSWGQPHGGSWGQPHGGGWGQGGGTHNQWNKPSKPKTNLKHVAGAAAAGAVVGGLGGYMLGSAMSRPMIHFGNDWEDRYYRENMYRYPNQVYYRPVDQYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCVTQYQKESQAYYDGRRSSSTVLFSSPPVILLISFLIFLIVG,positive +GGGAGAGAGGAAGAGGGAUGGGCGACCGAACGUGCCCUUCAAAGCCGUUCACUAACCAGUGGCAUAACCCAGAGGUCGAUAGUACUGGUCCCCCC,MEYASDASLDPEAPWPPAPRARACRVLPWALVAGLLLLLLLAAACAVFLACPWAVSGARASPGSAASPRLREGPELSPDDPAGLLDLRQGMFAQLVAQNVLLIDGPLSWYSDPGLAGVSLTGGLSYKEDTKELVVAKAGVYYVFFQLELRRVVAGEGSGSVSLALHLQPLRSAAGAAALALTVDLPPASSEARNSAFGFQGRLLHLSAGQRLGVHLHTEARARHAWQLTQGATVLGLFRVTPEIPAGLPSPRSE,positive +CAACCGAAGGACCUAUUCAGACCGC,MAKGEFIRTKPHVNVGTIGHVDHGKTTLTAALTYVAAAENPNVEVKDYGDIDKAPEERARGITINTAHVEYETAKRHYSHVDCPGHADYIKNMITGAAQMDGAILVVSAADGPMPQTREHILLARQVGVPYIVVFMNKVDMVDDPELLDLVEMEVRDLLNQYEFPGDEVPVIRGSALLALEEMHKNPKTKRGENEWVDKIWELLDAIDEYIPTPVRDVDKPFLMPVEDVFTITGRGTVATGRIERGKVKVGDEVEIVGLAPETRKTVVTGVEMHRKTLQEGIAGDNVGLLLRGVSREEVERGQVLAKPGSITPHTKFEASVYILKKEEGGRHTGFFTGYRPQFYFRTTDVTGVVRLPQGVEMVMPGDNVTFTVELIKPVALEEGLRFAIREGGRTVGAGVVTKILE,positive +UGUAGUUUCCCUGUAUGC,IMEIRTVAVGIVAIKGVESEYYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHSGGEMFVALNQKGLPVKGKKTKKEQKTAHFLPMAIT,positive +CCAGACGTGAGCACTAGATCAGTACGGAAG,MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA,positive +AAGACGGCCCGGUGUGUAGCCGGAGAUCCGAGACUUGCU,MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC,positive +TCCGGCGCGCTGAGTGCCGGTTTATCCTCGT,MGLLGILCFLIFLGKTWGQEQTYVISAPKIFRVGASENIVIQVYGYTEAFDATISIKSYPDKKFSYSSGHVHLSSENKFQNSAILTIQPKQLPGGQNPVSYVYLEVVSKHFSKSKRMPITYDNGFLFIHTDKPVYTPDQSVKVRVYSLNDDLKPAKRETVLTFIDPEGSEVDMVEEIDHIGIISFPDFKIPSNPRYGMWTIKAKYKEDFSTTGTAYFEVKEYVLPHFSVSIEPEYNFIGYKNFKNFEITIKARYFYNKVVTEADVYITFGIREDLKDDQKEMMQTAMQNTMLINGIAQVTFDSETAVKELSYYSLEDLNNKYLYIAVTVIESTGGFSEEAEIPGIKYVLSPYKLNLVATPLFLKPGIPYPIKVQVKDSLDQLVGGVPVTLNAQTIDVNQETSDLDPSKSVTRVDDGVASFVLNLPSGVTVLEFNVKTDAPDLPEENQAREGYRAIAYSSLSQSYLYIDWTDNHKALLVGEHLNIIVTPKSPYIDKITHYNYLILSKGKIIHFGTREKFSDASYQSINIPVTQNMVPSSRLLVYYIVTGEQTAELVSDSVWLNIEEKCGNQLQVHLSPDADAYSPGQTVSLNMATGMDSWVALAAVDSAVYGVQRGAKKPLERVFQFLEKSDLGCGAGGGLNNANVFHLAGLTFLTNANADDSQENDEPCKEILRPRRTLQKKIEEIAAKYKHSVVKKCCYDGACVNNDETCEQRAARISLGPRCIKAFTECCVVASQLRANISHKDMQLGRLHMKTLLPVSKPEIRSYFPESWLWEVHLVPRRKQLQFALPDSLTTWEIQGVGISNTGICVADTVKAKVFKDVFLEMNIPYSVVRGEQIQLKGTVYNYRTSGMQFCVKMSAVEGICTSESPVIDHQGTKSSKCVRQKVEGSSSHLVTFTVLPLEIGLHNINFSLETWFGKEILVKTLRVVPEGVKRESYSGVTLDPRGIYGTISRRKEFPYRIPLDLVPKTEIKRILSVKGLLVGEILSAVLSQEGINILTHLPKGSAEAELMSVVPVFYVFHYLETGNHWNIFHSDPLIEKQKLKKKLKEGMLSIMSYRNADYSYSVWKGGSASTWLTAFALRVLGQVNKYVEQNQNSICNSLLWLVENYQLDNGSFKENSQYQPIKLQGTLPVEARENSLYLTAFTVIGIRKAFDICPLVKIDTALIKADNFLLENTLPAQSTFTLAISAYALSLGDKTHPQFRSIVSALKREALVKGNPPIYRFWKDNLQHKDSSVPNTGTARMVETTAYALLTSLNLKDINYVNPVIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVKQLRLSMDIDVSYKHKGALHNYKMTDKNFLGRPVEVLLNDDLIVSTGFGSGLATVHVTTVVHKTSTSEEVCSFYLKIDTQDIEASHYRGYGNSDYKRIVACASYKPSREESSSGSSHAVMDISLPTGISANEEDLKALVEGVDQLFTDYQIKDGHVILQLNSIPSSDFLCVRFRIFELFEVGFLSPATFTVYEYHRPDKQCTMFYSTSNIKIQKVCEGAACKCVEADCGQMQEELDLTISAETRKQTACKPEIAYAYKVSITSITVENVFVKYKATLLDIYKTGEAVAEKDSEITFIKKVTCTNAELVKGRQYLIMGKEALQIKYNFSFRYIYPLDSLTWIEYWPRDTTCSSCQAFLANLDEFAEDIFLNGC,positive +CTCCTCTGACTGTAACCACGCCCATATCGGTGAATGCACGAGCAACCCGATTGACACGGGGCATAGGTAGTCCAGAAGCC,MLDLFADAEPWQEPLAAGAVILRRFAFNAAEQLIRDINDVASQSPFRQMVTPGGYTMSVAMTNCGHLGWTTHRQGYLYSPIDPQTNKPWPAMPQSFHNLCQRAATAAGYPDFQPDACLINRYAPGAKLSLHQDKDEPDLRAPIVSVSLGLPAIFQFGGLKRNDPLKRLLLEHGDVVVWGGESRLFYHGIQPLKAGFHPLTIDCRYNLTFRQAGKKE,positive +GAGACGGCCAGCCAAGGCGCUGAGAUCCGAGGUUUCAG,MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC,positive +UAUGAUGGUAGACGCCGUACCGCAUCAGGCCAAGUCGUCACAGAUCGUG,MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPGPHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR,positive +GGGAGAAGGGAAGTAACAGGAGCAUUAGCUACCAAGGGGUCGGGUUGUGGGUGAGAAGAGGTGACGGTACCAG,QELLCAASLISDRWVLTAAHCLLYPPWDKNFTVNDILVRIGKYARSRYERNMEKISTLEKIIIHPGYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDKQIVTSLLQAGHKGRVTGWGNLKEMWTVNMNEVQPSVLQMVNLPLVERPICKASTGIRVTDNMFCAGYKPEEGKRGDACEGDSGGPFVMKNPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIRKMVDRFG,positive +GAAUCAAUACACAGUCCUGGGUGCUAACCAUGAACACCCAAGGCCUUAGUGGUAUGUGGUUCUUG,MAGRSGDSDEELLKAVRLIKFLYQSNPPPNPEGTRQARRNRRRRWRERQRQIHSISERILSTYLGRSAEPVPLQLPPLERLTLDCNEDCGTSGTQGVGSPQILVESPTILESGAKE,positive +TGGCTAGTGGGTAAGGGGCGGGAGGGTGACAGGGCGATCC,MSMSPKHTTPFSVSDILSPLEESYKKVGMEGGGLGAPLAAYRQGQAAPPAAAMQQHAVGHHGAVTAAYHMTAAGVPQLSHSAVGGYCNGNLGNMSELPPYQDTMRNSASGPGWYGANPDPRFPAISRFMGPASGMNMSGMGGLGSLGDVSKNMAPLPSAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGGGGGGGAGCPQQQQAQQQSPRRVAVPVLVKDGKPCQAGAPAPGAGSLQGHAQQQAQQQAQAAQAAAAAISVGSGGPGLGAHPGHQPGSAGQSPDLAHHAASPAALQGQVSSLSHLNSSGSDYGTMSCSTLLYGRTW,positive +GGGAGAAUUCAACUGCCAUCUAUAGAAGAUGAUGCCUGGAUACAAUACAGCCACUCCUCGACUGUAAACCGAGUCCAGAAGCUUGUAGU,MSSSQKKAGGKAGKPTKRSQNYAALRKAQLPKPPALKVPVVKPTNTILPQTGCVWQSLGTPLSLSSFNGLGARFLYSFLKDFVGPRILEEDLIYRMVFSITPSHAGTFCLTDDVTTEDGRAVAHGNPMQEFPHGAFHANEKFGFELVFTAPTHAGMQNQNFKHSYAVALCLDFDAQPEGSKNPSFRFNEVWVERKAFPRAGPLRSLITVGLFDEADDLDRH,positive +AAAACUGAAGCCUCCGCGCUCACCGCGGCGGGCC,MAKGEFIRTKPHVNVGTIGHVDHGKTTLTAALTYVAAAENPNVEVKDYGDIDKAPEERARGITINTAHVEYETAKRHYSHVDCPGHADYIKNMITGAAQMDGAILVVSAADGPMPQTREHILLARQVGVPYIVVFMNKVDMVDDPELLDLVEMEVRDLLNQYEFPGDEVPVIRGSALLALEEMHKNPKTKRGENEWVDKIWELLDAIDEYIPTPVRDVDKPFLMPVEDVFTITGRGTVATGRIERGKVKVGDEVEIVGLAPETRKTVVTGVEMHRKTLQEGIAGDNVGLLLRGVSREEVERGQVLAKPGSITPHTKFEASVYILKKEEGGRHTGFFTGYRPQFYFRTTDVTGVVRLPQGVEMVMPGDNVTFTVELIKPVALEEGLRFAIREGGRTVGAGVVTKILE,positive +ACTCGAACATTTCCACTAACCAACCATACTAAAGCACCGC,MTVFLSFAFLAAILTHIGCSNQRRSPENSGRRYNRIQHGQCAYTFILPEHDGNCRESTTDQYNTNALQRDAPHVEPDFSSQKLQHLEHVMENYTQWLQKLENYIVENMKSEMAQIQQNAVQNHTATMLEIGTSLLSQTAEQTRKLTDVETQVLNQTSRLEIQLLENSLSTYKLEKQLLQQTNEILKIHEKNSLLEHKILEMEGKHKEELDTLKEEKENLQGLVTRQTYIIQELEKQLNRATTNNSVLQKQQLELMDTVHNLVNLCTKEGVLLKGGKREEEKPFRDCADVYQAGFNKSGIYTIYINNMPEPKKVFCNMDVNGGGWTVIQHREDGSLDFQRGWKEYKMGFGNPSGEYWLGNEFIFAITSQRQYMLRIELMDWEGNRAYSQYDRFHIGNEKQNYRLYLKGHTGTAGKQSSLILHGADFSTKDADNDNCMCKCALMLTGGWWFDACGPSNLNGMFYTAGQNHGKLNGIKWHYFKGPSYSLRSTTMMIRPLDF,positive +TACGTGAGCGTGCTGTCCCCTAAAGGTGATACGTC,PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGKISKIGPENPYNTPVFAIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDESFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPXRXKNPEMVIYQYMDDLYVGSDLEIGQHRAKIEELRSHLLSWGFTTPDKKHQKEPPFLWMGYELHPDSWTVQPIELPEKDSWTVNE,positive +CAGGTCAGTTCAGCGGATCCTGTCGAAAAACACACACCCCGAGGCGAATTCAGTGCAACTGCAGC,SNTRNFVLRDEDGNEHGVFTGKQPRQAALKAANRGSGTKANPDIIRLRERGTKKVHVFKAWKEIVDAPKNRPAWMPEKISKPFVKKERIEKLE,positive +AAAGAGCUAAUGUAGGAUGCUGGGGUAGUCCAGCCCUAGAAUAAGCGCUAGUACUACAAGCUUCUGGAGCUCGGU,MASTSRLDALPRVTCPNHPDAILVEDYRAGDMICPECDRVIDVGSEWRTFSNDKATKDPSRVGDSQNPLLSDGDLSTMIGKGTGAASFDEFGNSKYQNRRTMSSSDRAMMNAFKEITTMADRINLPRNIVDRTNNLFKQVYEQKSLKGRANDAIASACLYIACRQEGVPRTFKEICAVSRISKKEIGRCFKLILKALETSVDLITTGDFMSRFCSNLCLPKQVQMAATHIA,positive +GATTGAAAGGTCTGTTTTTGGGGTTGGTTTGGGTCAATA,MGVHECPAWLWLLLSLLSLPLGLPVLGAPPRLICDSRVLERYLLEAKEAENITTGCAEHCSLNENITVPDTKVNFYAWKRMEVGQQAVEVWQGLALLSEAVLRGQALLVNSSQPWEPLQLHVDKAVSGLRSLTTLLRALGAQKEAISPPDAASAAPLRTITADTFRKLFRVYSNFLRGKLKLYTGEACRTGDR,positive +AATTTCTAATATAATTTCTAATAT,MDHLNEATQGKEHSEMSNNVSDPKGPPAKIARLEQNGSPLGRGRLGSTGAKMQGVPLKHSGHLMKTNLRKGTMLPVFCVVEHYENAIEYDCKEEHAEFVLVRKDMLFNQLIEMALLSLGYSHSSAAQAKGLIQVGKWNPVPLSYVTDAPDATVADMLQDVYHVVTLKIQLHSCPKLEDLPPEQWSHTTVRNALKDLLKDMNQSSLAKECPLSQSMISSIVNSTYYANVSAAKCQEFGRWYKHFKKTKDMMVEMDSLSELSQQGANHVNFGQQPVPGNTAEQPPSPAQLSHGSQPSVRTPLPNLHPGLVSTPISPQLVNQQLVMAQLLNQQYAVNRLLAQQSLNQQYLNHPPPVSRSMNKPLEQQVSTNTEVSSEIYQWVRDELKRAGISQAVFARVAFNRTQGLLSEILRKEEDPKTASQSLLVNLRAMQNFLQLPEAERDRIYQDERERSLNAASAMGPAPLISTPPSRPPQVKTATIATERNGKPENNTMNINASIYDEIQQEMKRAKVSQALFAKVAATKSQGWLCELLRWKEDPSPENRTLWENLSMIRRFLSLPQPERDAIYEQESNAVHHHGDRPPHIIHVPAEQIQQQQQQQQQQQQQQQAPPPPQPQQQPQTGPRLPPRQPTVASPAESDEENRQKTRPRTKISVEALGILQSFIQDVGLYPDEEAIQTLSAQLDLPKYTIIKFFQNQRYYLKHHGKLKDNSGLEVDVAEYKEEELLKDLEESVQDKNTNTLFSVKLEEELSVEGNTDINTDLKD,positive +AGTCCGTGGTAGGGCAGGTTGGGGTGACT,ASFTCLAIWALASAGVVPLVLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAAFFFVPVIISTVCYVSIIRCLSSSAVANRSKK,positive +UCGCCAACAGGCGG,MASNFTQFVLVDNGGTGDVTVAPSNFANGVAEWISSNSRSQAYKVTCSVRQSSAQNRKYTIKVEVPKVATQTVGGVELPVAAWRSYLNMELTIPIFATNSDCELIVKAMQGLLKDGNPIPSAIAANSGIY,positive +AUCGCAUCUGAACCGGCCCAGCAGACUGCUGACGGCACGAU,MGVLLTQRTLLSLVLALLFPSMASMAAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQGLDVPKLREHCRERPGAFPSEETLRGLGRRGFLQTLNATLGCVLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILGLRNNIYCMAQLLDNSDTAEPTKAGRGASQPPTPTPASDAFQRKLEGCRFLHGYHRFMHSVGRVFSKWGESPNRSRRHSPHQALRKGVRRTRPSRKGKRLMTRGQLPR,positive +GACTGCGTATCAACGCGGTGAAACCTAACCTCATCTTGAT,MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH,positive +ACACCCUCAACAAGUCCCGCCAACAACGC,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,positive +CACUCAGCGCCCUGCGAAACGUUGCCGCCUCCCAACGUCU,MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYTFLLPEMDNCRSSSSPYVSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQDNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVLVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF,positive +GGGAGAGGAGGGAGAUAGAUAUCAAGAUAAAAACGCCGGCGUAGCGCUGCAGCGCAAAAAAACACGACUGCUCGCACGAGGUGACUCAGGCAGAGAAGGCGAGUUUCGUGGAUGCCACAGGAC,VVIRSNNFTDNAKTIIVQLNESIAINCTRPNNNTRKSIHIGPGRAFYTTGDIIGNIRQAHCNLSRTKWENTLKQIAKKLREQFGNKTIVFNH,positive +ATACCAGTCTATTCAATTGGGCGGGGACTGTCGGGATGTGTGTGGGCCAGATAGTATGTGCAATCA,MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPGPHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR,positive +CTAAGGATCGGATCCACGGCCTACCAGGTC,MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA,positive +CAGCTCAGAAGCTTGATCCTGTGCGGGCGGCAAGGCCCTGACAGAGATACTGGCTCGGGACTCGAAGTCGTGCATCTGCA,QDRPIKFSTEGATSQSYKQFIEALRERLRGGLIHDIPVLPDPTTLQERNRYITVELSNSDTESIEVGIDVTNAYVVAYRAGTQSYFLRDAPSSASDYLFTGTDQHSLPFYGTYGDLERWAHQSRQQIPLGLQALTHGISFFRSGGNDNEEKARTLIVIIQMVAEAARFRYISNRVRVSIQTGTAFQPDAAMISLENNWDNLSRGVQESVQDTFPNQVTLTNIRNEPVIVDSLSHPTVAVLALMLFVCNPPNANQSPLLIRSIVEKSKICSSRYEPTVRIGGRDGMCVDVYDNGYHNGNRIIMWKCKDRLEENQLWTLKSDKTIRSNGKCLTTYGYAPGSYVMIYDCTSAVAEATYWEIWDNGTIINPKSALVLSAESSSMGGTLTVQTNEYLMRQGWRTGNNTSPFVTSISGYSDLCMQAQGSNVWMADCDSNKKEQQWALYTDGSIRSVQNTNNCLTSKDHKQGSTILLMGCSNGWASQRWVFKNDGSIYSLYDDMVMDVKGSDPSLKQIILWPYTGKPNQIWLTLF,positive +TATTAGTAATCATATTAGTAATCA,MDHLNEATQGKEHSEMSNNVSDPKGPPAKIARLEQNGSPLGRGRLGSTGAKMQGVPLKHSGHLMKTNLRKGTMLPVFCVVEHYENAIEYDCKEEHAEFVLVRKDMLFNQLIEMALLSLGYSHSSAAQAKGLIQVGKWNPVPLSYVTDAPDATVADMLQDVYHVVTLKIQLHSCPKLEDLPPEQWSHTTVRNALKDLLKDMNQSSLAKECPLSQSMISSIVNSTYYANVSAAKCQEFGRWYKHFKKTKDMMVEMDSLSELSQQGANHVNFGQQPVPGNTAEQPPSPAQLSHGSQPSVRTPLPNLHPGLVSTPISPQLVNQQLVMAQLLNQQYAVNRLLAQQSLNQQYLNHPPPVSRSMNKPLEQQVSTNTEVSSEIYQWVRDELKRAGISQAVFARVAFNRTQGLLSEILRKEEDPKTASQSLLVNLRAMQNFLQLPEAERDRIYQDERERSLNAASAMGPAPLISTPPSRPPQVKTATIATERNGKPENNTMNINASIYDEIQQEMKRAKVSQALFAKVAATKSQGWLCELLRWKEDPSPENRTLWENLSMIRRFLSLPQPERDAIYEQESNAVHHHGDRPPHIIHVPAEQIQQQQQQQQQQQQQQQAPPPPQPQQQPQTGPRLPPRQPTVASPAESDEENRQKTRPRTKISVEALGILQSFIQDVGLYPDEEAIQTLSAQLDLPKYTIIKFFQNQRYYLKHHGKLKDNSGLEVDVAEYKEEELLKDLEESVQDKNTNTLFSVKLEEELSVEGNTDINTDLKD,positive +CGCGGATCCTGCAGCTCGAGAGCGGTGGGTGTTTACGTGTTTTTGTTTACCTCTAGAAGCTTGTCGAC,AKTALQVPLPHPMQMNALGGYSPASTCNGYGRMGLHQEKLPSDLDGMFIERLDCDMESIIRNDLMDGDTLDFNFDNVLPNQSFPHSVKTTTHSWVSG,positive +UGGUCUCCCAAUUCUAAACUUUCUCCAUCGUAUCUGGG,IMEIRTVAVGIVAIKGVESEYYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHSGGEMFVALNQKGLPVKGKKTKKEQKTAHFLPMAIT,positive +AGCAGCACAGAGGTCAGATGGTTCGTTGTAGCGCATAAAGTTTATCTCTCCCATGATTCACCTATGCGTGCTACCGTGAA,MLSWGYFLFLLPTLPGAQSQVQLVESGGDVRKPGDSLRLSCKGSGFTFSNYWLGWVRQAPGKALNGSLPLTPLAAAPTYIPGVSGRFTISRDNARALLHLDMSDLRPEDTGRYHCER,positive +GGGAGCUCAGCCUUCACUGCACUCCGGCUGGUGGACGCGGUACGAGCAAUUUGUACCGGAUGGAUGUUCGGGCAGCGGUGUGGCAGGGAUGAGCGGCACCACGGUCGGAUCCAC,MSPQRDRINAFYKDNPHPKGSRIVINREHLMIDRPYVLLAVLFVMFLSLIGLLAIAGIRLHRAAIYTAEIHKSLSTNLDVTNSIEHQVKDVLTPLFKIIGDEVGLRTPQRFTDLVKFISDKIKFLNPDREYDFRDLTWCINPPERIKLDYDQYCADVAAEELMNALVNSTLLEARATNQFLAVSKGNCSGPTTIRGQFSNMSLSLLDLYLSRGYNVSSIVTMTSQGMYGGTYLVEKPNLSSKGSELSQLSMHRVFEVGVIRNPGLGAPVFHMTNYFEQPVSNDFSNCMVALGELKFAALCHREDSITIPYQGSGKDVSFQLVKLGVWKSPTDMQSWVPLSTDDPVIDRLYLSSHRGVIADNQAKWAVPTTRTDDKLRMETCFQQACKGKIQALCENPDWAPLKDNRIPSYGVLSVNLSLTVELKIKIASGFGPLITHGSGMDLYKSNHNNMYWLTIPPMKNLALGVINTLEWIPRFRVSPNLFTVPIKEAGEDCHAPTYLPAEVDGDVKLSSNLVILPGQDLQYVLATYDTSRVEHAVVYYVYSPSRSFSYFYPFRLPIKGVPIELQVECFTWDQKLWCRHFCVLADSGSGGHITHSGMVGMGVSCTVTREDGTNRR,positive +CAUUACAGCGAAGUUACCAGCCAUACACGGUACAAAUGCGCCCGACUAGU,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,positive +GGAGUCUUAGGCAGCGCGUUUUCGAGCUACUCCA,MGCRRTREGPSKAMIFPWKCQSTQRDLWNIFKLWGWTMLCCDFLAHHGTDCWTYHYSEKPMNWQRARRFCRDNYTDLVAIQNKAEIEYLEKTLPFSRSYYWIGIRKIGGIWTWVGTNKSLTEEAENWGDGEPNNKKNKEDCVEIYIKRNKDAGKWNDDACHKLKAALCYTASCQPWSCSGHGECVEIINNYTCNCDVGYYGPQCQFVIQCEPLEAPELGTMDCTHPLGNFSFSSQCAFSCSEGTNLTGIEETTCGPFGNWSSPEPTCQVIQCEPLSAPDLGIMNCSHPLASFSFTSACTFICSEGTELIGKKKTICESSGIWSNPSPICQKLDKSFSMIKEGDYNPLFIPVAVMVTAFSGLAFIIWLARRLKKGM,positive +UAAAUCGUUGCUACAUUCCCAAUUGAACGGCCCGGGUUCUUAACACGUGC,MAAKVASTSSEEAEGSLVTEGEMGEKALPVVYKRYICSFADCGAAYNKNWKLQAHLCKHTGEKPFPCKEEGCEKGFTSLHHLTRHSLTHTGEKNFTCDSDGCDLRFTTKANMKKHFNRFHNIKICVYVCHFENCGKAFKKHNQLKVHQFSHTQQLPYECPHEGCDKRFSLPSRLKRHEKVHAGYPCKKDDSCSFVGKTWTLYLKHVAECHQDLAVCDVCNRKFRHKDYLRDHQKTHEKERTVYLCPRDGCDRSYTTAFNLRSHIQSFHEEQRPFVCEHAGCGKCFAMKKSLERHSVVHDPEKRKLKEKCPRPKRSLASRLTGYIPPKSKEKNASVSGTEKTDSLVKNKPSGTETNGSLVLDKLTIQ,positive +UUAGCACAAACAACCCCAGAAGUGCAACGC,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,positive +AGUAAUACGACUCACUAUAGGGAGAAUUCCGACCAGAAGGGUUAGCGGUCGUCUUAAGUAGUUUUUGGUCCUUUCCUCUCUCCUUCCUCUUCU,MSPQRDRINAFYKDNPHPKGSRIVINREHLMIDRPYVLLAVLFVMFLSLIGLLAIAGIRLHRAAIYTAEIHKSLSTNLDVTNSIEHQVKDVLTPLFKIIGDEVGLRTPQRFTDLVKFISDKIKFLNPDREYDFRDLTWCINPPERIKLDYDQYCADVAAEELMNALVNSTLLEARATNQFLAVSKGNCSGPTTIRGQFSNMSLSLLDLYLSRGYNVSSIVTMTSQGMYGGTYLVEKPNLSSKGSELSQLSMHRVFEVGVIRNPGLGAPVFHMTNYFEQPVSNDFSNCMVALGELKFAALCHREDSITIPYQGSGKDVSFQLVKLGVWKSPTDMQSWVPLSTDDPVIDRLYLSSHRGVIADNQAKWAVPTTRTDDKLRMETCFQQACKGKIQALCENPDWAPLKDNRIPSYGVLSVNLSLTVELKIKIASGFGPLITHGSGMDLYKSNHNNMYWLTIPPMKNLALGVINTLEWIPRFRVSPNLFTVPIKEAGEDCHAPTYLPAEVDGDVKLSSNLVILPGQDLQYVLATYDTSRVEHAVVYYVYSPSRSFSYFYPFRLPIKGVPIELQVECFTWDQKLWCRHFCVLADSGSGGHITHSGMVGMGVSCTVTREDGTNRR,positive +UUAUUAUUGUUUAUUUUGUGUUGUGUGUUUGUGUU,MAWYWWRRRRRRGWWKPRRRRWRRRRARRRGPARRHRARRRIVRHPCNGQTSSGNRVPRSVQAVDPKYVSLQLVWHSWDFRRGLFGQAGIKRMQQESDALTLSPVHRPKRPKRDTQVKEKTPEKDSDSAVQLRRLQPWIHSSQETKDEEEEIPEGPVQEQLLQQLQQQRLLRVQLESIAQEVLKIRRGHSLHPLLSSHA,positive +CCTTCGTTGTCTGCCTTCGTTAATCGGCTCGATTGATTCGAGGTGACGGTCGTTGGACGTGACGTTACGCACCCTTCAGAATTCGCACCA,MKQYLNTVISNPRPAQALGINQPFVVFCFITSRALSFVPAIYWCFKCLHLAFVADKFKWLPLTSALWTLVSAYLSFVLANGFLLKWLIHYSIGPTIIRLFSLNVINFSFLSLSVSFITHGDNAYLLPAWIAISCFQTAAYIVQDWITSPIIRTLPFRSSSSSSSNYRHNLDFLEITVFAVVPVGIASFFTMVMLIWQLYKYPDSFLVSA,positive +ATATTCGCGATTATT,MSARGEEAAGEASGSQEQPEPALAEPKKRGPGRPRKPQQEPTGEPVPKRPRGRPKGSKNKGPSKAAQKKAETTGEKRPRGRPRKWPQQVVQEKPAQEEEEEEEEEEAEED,positive +GGGAGCTCAGAATAAACGCTCAACATGGATGGGAGGGTGGGGCTGGGTTGTAGAATATTCGACATGAGGCCCGGATC,MLNQLDNLTERVRGSNKLVDRWLHVRKHLLVAYYNLVGIKPGKESYMRLNEKALDDFCQSLVDYLSAGHFSIYERILHKLEGNGQLARAAKIWPQLEANTQQIMDYYDSSLETAIDHDNYLEFQQVLSDIGEALEARFVLEDKLILLVLDAARVKHPA,positive +GGCAGCGAGAGCAAAACAAGUAUGAGACCCAGCUACGGCGACUUCUCAUGCGUAGCCAAACCCA,MTSHYVIAIFALMSSCLATAGPEPGALCELSPVSASHPVQALMESFTVLSGCASRGTTGLPQEVHVLNLRTAGQGPGQLQREVTLHLNPISSVHIHHKSVVFLLNSPHPLVWHLKTERLATGVSRLFLVSEGSVVQFSSANFSLTAETEERNFPHGNEHLLNWARKEYGAVTSFTELKIARNIYIKVGEDQVFPPKCNIGKNFLSLNYLAEYLQPKAAEGCVMSSQPQNEEVHIIELITPNSNPYSAFQVDITIDIRPSQEDLEVVKNLILILKCKKSVNWVIKSFDVKGSLKIIAPNSIGFGKESERSMTMTKSIRDDIPSTQGNLVKWALDNGYSPITSYTMAPVANRFHLRLENNAEEMGDEEVHTIPPELRILLDPGALPALQNPPIRGGEGQNGGLPFPFPDISRRVWNEEGEDGLPRPKDPVIPSIQLFPGLREPEEVQGSVDIALSVKCDNEKMIVAVEKDSFQASGYSGMDVTLLDPTCKAKMNGTHFVLESPLNGCGTRPRWSALDGVVYYNSIVIQVPALGDSSGWPDGYEDLESGDNGFPGDMDEGDASLFTRPEIVVFNCSLQQVRNPSSFQEQPHGNITFNMELYNTDLFLVPSQGVFSVPENGHVYVEVSVTKAEQELGFAIQTCFISPYSNPDRMSHYTIIENICPKDESVKFYSPKRVHFPIPQADMDKKRFSFVFKPVFNTSLLFLQCELTLCTKMEKHPQKLPKCVPPDEACTSLDASIIWAMMQNKKTFTKPLAVIHHEAESKEKGPSMKEPNPISPPIFHGLDTLTVMGIAFAAFVIGALLTGALWYIYSHTGETAGRQQVPTSPPASENSSAAHSIGSTQSTPCSSSSTA,positive +GGGAGGACGATGCGGGCGAAGGCACACCGAGTTCATAGTATCCCACAGACGACGAGCGGGA,MKEFEVKVASTAFVLVLFSLTINQILASETSTKFRSPVPAPTVPDWNHLPNEGNEENVVSAPKQDGASGGQKPYWTKREKMMKRLHAEPAGNTVRFRCAVDGNPKPQVLWYKNDLIVQKNDRVGGYKYRNQVLILESVVLSDKGNYMCVARNEYGSINHTYQLDVQERSASKPILAEGLPQNKSAYIGDDVTFKCKVYSDAHPHIQWLKSINNHNNAAPNYTVLKAAGVNTTDLDMEVLILKNVSFEEAGEYTCLAGNSIGISHQSAWLSVLPVPPPTTDTITKGIPNETNIIIYVMCGVLVILFGLAVVLVLYYHCYNGKDPPMLVRIENPDNIPPMTKIEHPTMLFGNTQAWQRMCMPMQEPFEFNIQLDLQWELQREDITLVERLDEGFFGQVFKADLVTCNNTRKEKMVCAVKMLKGNRNEKDVLDLLTEMDQMKRVGKHKNIINLLGVCTQNGPLWLVIEYAAQGNLRDYLRRNRPQNTLCNLVLPSEGRNPDDELPVPHGDTLTQKDIVSFAFQVARGLEFLAQKKCIHRDLAARNVLVTEELVMKIADFGLARDIRSCDYYRKHTRGHLPYKWMALEAMSDNIFTHATDVWSFGVLLWEIFSLAGSPYPGIKTHELVKFLRSGERLDKPQYASQEMYRLMRDCWEEDPSKRPNFRTLVEDLDRMLAESSTEVYIDFAAGCEAEYSESSEDESESQNSDEEDDDSVFERMRQIDSLSNGNIPFNEEDSSNSDPYVAPLLQNEENVLQNEHARLRSEA,positive +AGCATATAGTATAAAATTATCATATTGGTGTACGTGTACGGGGTACTTTT,MAITKINDCFELLSMVTYADKLKSLIKKEFSISFEEFAVLTYISENKEKEYYLKDIINHLNYKQPQVVKAVKILSQEDYFDKKRNEHDERTVLILVNAQQRKKIESLLSRVNKRITEANNEIEL,positive +AATACGACTCACTATAGAGGGAGGACGATGCGGGATGGACGCTTATCCGCATAGAGGTTTACTACTTCGGAGACTGCCGATACAGACGACGGA,MTRCTADNSLTNPAYRRRTMATGEMKEFLGIKGTEPTDFGINSDAQDLPSPSRQASTRRMSIGESIDGKINDWEEPRLDIEGFVVDYFTHRIRQNGMEWFGAPGLPCGVQPEHEMMRVMGTIFEKKHAENFETFCEQLLAVPRISFSLYQDVVRTVGNAQTDQCPMSYGRLIGLISFGGFVAAKMMESVELQGQVRNLFVYTSLFIKTRIRNNWKEHNRSWDDFMTLGKQMKEDYERAEAEKVGRRKQNRRWSMIGAGVTAGAIGIVGVVVCGRMMFSLK,positive +TATGGGAGCATATACTATTCTATGATATTTCTATGCAATTCAAGAGTCTA,MAITKINDCFELLSMVTYADKLKSLIKKEFSISFEEFAVLTYISENKEKEYYLKDIINHLNYKQPQVVKAVKILSQEDYFDKKRNEHDERTVLILVNAQQRKKIESLLSRVNKRITEANNEIEL,positive +GGAGUCUUAGGCAGCGCGUUUUCGAGCUACUCCA,MGCRRTREGPSKAMIFPWKCQSTQRDLWNIFKLWGWTMLCCDFLAHHGTDCWTYHYSEKPMNWQRARRFCRDNYTDLVAIQNKAEIEYLEKTLPFSRSYYWIGIRKIGGIWTWVGTNKSLTEEAENWGDGEPNNKKNKEDCVEIYIKRNKDAGKWNDDACHKLKAALCYTASCQPWSCSGHGECVEIINNYTCNCDVGYYGPQCQFVIQCEPLEAPELGTMDCTHPLGNFSFSSQCAFSCSEGTNLTGIEETTCGPFGNWSSPEPTCQVIQCEPLSAPDLGIMNCSHPLASFSFTSACTFICSEGTELIGKKKTICESSGIWSNPSPICQKLDKSFSMIKEGDYNPLFIPVAVMVTAFSGLAFIIWLARRLKKGM,positive +TTAGCAAAGTTGAAGCCGGACTAACAAGCTCTACG,PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGKISKIGPENPYNTPVFAIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDESFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPXRXKNPEMVIYQYMDDLYVGSDLEIGQHRAKIEELRSHLLSWGFTTPDKKHQKEPPFLWMGYELHPDSWTVQPIELPEKDSWTVNE,positive +AGCGCGCACCTACTGTGATGTAGAAGTCACAGCAAGGCCC,MPSNQEARLFLAVLVLAQVLPILVDSAAEKGFKQAFWQPLCQVSEELDDQPKGALFTLQAAASKIQKMRDAALRASIYAEINHGTNRAKAAVIVANHYAMKADSGLEALKQTLSSQEVTATATASYLKGRIDEYLNLLLQTKESGTSGCMMDTSGTNTVTKAGGTIGGVPCKLQLSPIQPKRPAATYLGKAGYVGLTRQADAANNFHDNDAECRLASGHNTNGLGKSGQLSAAVTMAAGYVTVANSQTAVTVQALDALQEASGAAHQPWIDAWKAKKALTGAETAEFRNETAGIAGKTGVTKLVEEALLKKKDSEASEIQTELKKYFSGHENEQWTAIEKLISEQPVAQNLVGDNQPTKLGELEGNAKLTTILAYYRMETAGKFEVLTQKHKPAESQQQAAETEGSCNKKDQNECKSPCKWHNDAENKKCTLDKEEAKKVADETAKDGKTGNTNTTGSSNSFVISKTPLWLAVLLF,positive +AAGACGGCCGGGGAAACCCGAGGUCCGAGGUAACGC,MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC,positive +GUGGUGAAGAGGUACCGGAAUUGCUAAAGAUACCACGGCC,IMEIRTVAVGIVAIKGVESEYYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHSGGEMFVALNQKGLPVKGKKTKKEQKTAHFLPMAIT,positive +TCTCATGCGTCGAGTGTGAGTTTAACTGCGT,MGLLGILCFLIFLGKTWGQEQTYVISAPKIFRVGASENIVIQVYGYTEAFDATISIKSYPDKKFSYSSGHVHLSSENKFQNSAILTIQPKQLPGGQNPVSYVYLEVVSKHFSKSKRMPITYDNGFLFIHTDKPVYTPDQSVKVRVYSLNDDLKPAKRETVLTFIDPEGSEVDMVEEIDHIGIISFPDFKIPSNPRYGMWTIKAKYKEDFSTTGTAYFEVKEYVLPHFSVSIEPEYNFIGYKNFKNFEITIKARYFYNKVVTEADVYITFGIREDLKDDQKEMMQTAMQNTMLINGIAQVTFDSETAVKELSYYSLEDLNNKYLYIAVTVIESTGGFSEEAEIPGIKYVLSPYKLNLVATPLFLKPGIPYPIKVQVKDSLDQLVGGVPVTLNAQTIDVNQETSDLDPSKSVTRVDDGVASFVLNLPSGVTVLEFNVKTDAPDLPEENQAREGYRAIAYSSLSQSYLYIDWTDNHKALLVGEHLNIIVTPKSPYIDKITHYNYLILSKGKIIHFGTREKFSDASYQSINIPVTQNMVPSSRLLVYYIVTGEQTAELVSDSVWLNIEEKCGNQLQVHLSPDADAYSPGQTVSLNMATGMDSWVALAAVDSAVYGVQRGAKKPLERVFQFLEKSDLGCGAGGGLNNANVFHLAGLTFLTNANADDSQENDEPCKEILRPRRTLQKKIEEIAAKYKHSVVKKCCYDGACVNNDETCEQRAARISLGPRCIKAFTECCVVASQLRANISHKDMQLGRLHMKTLLPVSKPEIRSYFPESWLWEVHLVPRRKQLQFALPDSLTTWEIQGVGISNTGICVADTVKAKVFKDVFLEMNIPYSVVRGEQIQLKGTVYNYRTSGMQFCVKMSAVEGICTSESPVIDHQGTKSSKCVRQKVEGSSSHLVTFTVLPLEIGLHNINFSLETWFGKEILVKTLRVVPEGVKRESYSGVTLDPRGIYGTISRRKEFPYRIPLDLVPKTEIKRILSVKGLLVGEILSAVLSQEGINILTHLPKGSAEAELMSVVPVFYVFHYLETGNHWNIFHSDPLIEKQKLKKKLKEGMLSIMSYRNADYSYSVWKGGSASTWLTAFALRVLGQVNKYVEQNQNSICNSLLWLVENYQLDNGSFKENSQYQPIKLQGTLPVEARENSLYLTAFTVIGIRKAFDICPLVKIDTALIKADNFLLENTLPAQSTFTLAISAYALSLGDKTHPQFRSIVSALKREALVKGNPPIYRFWKDNLQHKDSSVPNTGTARMVETTAYALLTSLNLKDINYVNPVIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVKQLRLSMDIDVSYKHKGALHNYKMTDKNFLGRPVEVLLNDDLIVSTGFGSGLATVHVTTVVHKTSTSEEVCSFYLKIDTQDIEASHYRGYGNSDYKRIVACASYKPSREESSSGSSHAVMDISLPTGISANEEDLKALVEGVDQLFTDYQIKDGHVILQLNSIPSSDFLCVRFRIFELFEVGFLSPATFTVYEYHRPDKQCTMFYSTSNIKIQKVCEGAACKCVEADCGQMQEELDLTISAETRKQTACKPEIAYAYKVSITSITVENVFVKYKATLLDIYKTGEAVAEKDSEITFIKKVTCTNAELVKGRQYLIMGKEALQIKYNFSFRYIYPLDSLTWIEYWPRDTTCSSCQAFLANLDEFAEDIFLNGC,positive +AGUGAGGUCAACGAUCUUGGGCCCGUUGACGGGAAGCGUAGAACUACAAGCUUCUGGACUCGGU,MASTSRLDALPRVTCPNHPDAILVEDYRAGDMICPECDRVIDVGSEWRTFSNDKATKDPSRVGDSQNPLLSDGDLSTMIGKGTGAASFDEFGNSKYQNRRTMSSSDRAMMNAFKEITTMADRINLPRNIVDRTNNLFKQVYEQKSLKGRANDAIASACLYIACRQEGVPRTFKEICAVSRISKKEIGRCFKLILKALETSVDLITTGDFMSRFCSNLCLPKQVQMAATHIA,positive +UUUGGUUAUCAUGUUUAUGCGUACGGGCGCCCAU,MEPVDPRLEPWKHPGSQPKTACTNCYCKKCCFHCQVCFITKALGISYGRKKRRQRRRAHQNSQTHQASLSKQPTSQPRGDPTGPKE,positive +UCGAUCACACAGUUCAAACGUAAUAAGCCAAUGUACGAGG,LQENFLPQPRQQHHGTLVLHYRPHREEAGMQHPCLWPGSSHCSDDSTLRRLQCESVTSIGAVCP,positive +GTAGATTGAATTAATTGGAAGAGTCGATCAGTGTTTAATG,MPEEWVRIFGEAGITQFEQQRNPRLCLSVLNILSKSEHPQEKFMFVPYEQSALPVTDNSPFGDTSITHNYADHHFKASTPENEGSSFYSRVPGPCTVGVRSSSLSSGRGSSEGVGSRSGSGSGGAASRSSSSGHGGAGFPLPVTSVPANGRSSAPGPNSMTVTSGSHSSSGSNCSTGSLTGGMELTNTMVATTQRTGPNNVLVNGHSTGNHFHGGVTQRVAASAAPTECNVLPTYTGSSSSYQPTSFQSMAVHTPPAYTLRQIPPAHSIGYPYTSTAPTSESIILTAPTTTPSSTVYHTTQGSAIVKPLSDNQSQRDKLPYLMHKSQWHSNVTGHVPLSPGLPRRFVDGVLPPETSAHIQYSSGQSSPSPAGSATPVPTPRRESLAGSVPVRAGPAPPALATHELSSDANCTLTPPPVATRPEKTKSIYTKPVEAQCDGHLTIGDQQDASRRSLETPVPPQTAATIHGSENETRTNVTVLPTVHSDGNNSSVHAYQQATESRPLKPNTLERQGQKKVRPKISDEAIQEKLRMIVSIGDPNRKYQRQEKIGQGASGTVYGGIEVATGRRVAIKQMNLKQQPKKELIVNEIYVMKAKKHPNVVNYLDSYLVADELWVVMEYLDGGSLTEVVTETYMEEGQIAAVCRECLQALDFLHKNQVIHRDIKSDNILLGLDGSVKLTDFGFCAQLSSEQNKRSTMVGTPYWMAPEVVTRKQYGPKVDIWSLGIMAIEMLDGEPPYLNENPVRALYLIGTNGKPEIKERDKLSSEFQDFLDLCLEVKVERRATAQELLQHIFSRDGHRAMELLQTDNFHSSGVRKKRTPRLAIEKLVDPEVKRNYQNQLVECLPDGTVSDINGHWEKISKALLKPRRTVVMAAGEDELVVTVRGTSFNCPPTSLVEPNTGIIAPLIEPHHRGIGSYALEVVADIIGTLDYCGIAFLTMGSFVPYLYYSFYCVLWLKLFYLALIFALGSGAIAVSMSNTFASPAYRPLRALVFIALGLSGVIPCVHVTITNGFWPSLQHGSLGWLFLMAVLYITGASIYAVRVPERIFPGRFDIWFQSHQIFHVFVVAAALVHYHGIIGLTNYRLAIGDCRPPPGYPFPKHDYDNIELLRPFMTY,positive +GUUCACUCGAAUCUUCAGAACACGCAACGG,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,positive +ACCAAAATCAACGCAAAGAGCGCGCCTGCACGTCACCTCA,MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA,positive +CCCCCAUGGCACGCCGAUCACGUUUUGCUGUCCGCCGGUCCAUAAAUACU,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,positive +BAGCGCCGGTGGTGGTGGGGGTTGTTGTTACGCGGTATTAT,MVDREQLVQKARLAEQAERYDDMAAAMKNVTELNEPLSNEERNLLSVAYKNVVGARRSSWRVISSIEQKTSADGNEKKIEMVRAYREKIEKELEAVCQDVLSLLDNYLIKNCSETQYESKVFYLKMKGDYYRYLAEVATGEKRATVVESSEKAYSEAHEISKEHMQPTHPIRLGLALNYSVFYYEIQNAPEQACHLAKTAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDQQDDDGGEGNN,positive +AGGGAGCAAUGAACUCAAGUCAAGCCGGGCACGUGGG,IMEIRTVAVGIVAIKGVESEYYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHSGGEMFVALNQKGLPVKGKKTKKEQKTAHFLPMAIT,positive +GGGAGAAUUCAACUGCCAUCUAUAGAGAUGAAGCCAAGCUUCUUUCCCUUAUGGGCCCGUAAACCGAGUCCAGAAGCUUGUAGU,MSSSQKKAGGKAGKPTKRSQNYAALRKAQLPKPPALKVPVVKPTNTILPQTGCVWQSLGTPLSLSSFNGLGARFLYSFLKDFVGPRILEEDLIYRMVFSITPSHAGTFCLTDDVTTEDGRAVAHGNPMQEFPHGAFHANEKFGFELVFTAPTHAGMQNQNFKHSYAVALCLDFDAQPEGSKNPSFRFNEVWVERKAFPRAGPLRSLITVGLFDEADDLDRH,positive +TGACTGCCGCACCGACCATTCACGGTATTTGGCACGGCC,MPSNQEARLFLAVLVLAQVLPILVDSAAEKGFKQAFWQPLCQVSEELDDQPKGALFTLQAAASKIQKMRDAALRASIYAEINHGTNRAKAAVIVANHYAMKADSGLEALKQTLSSQEVTATATASYLKGRIDEYLNLLLQTKESGTSGCMMDTSGTNTVTKAGGTIGGVPCKLQLSPIQPKRPAATYLGKAGYVGLTRQADAANNFHDNDAECRLASGHNTNGLGKSGQLSAAVTMAAGYVTVANSQTAVTVQALDALQEASGAAHQPWIDAWKAKKALTGAETAEFRNETAGIAGKTGVTKLVEEALLKKKDSEASEIQTELKKYFSGHENEQWTAIEKLISEQPVAQNLVGDNQPTKLGELEGNAKLTTILAYYRMETAGKFEVLTQKHKPAESQQQAAETEGSCNKKDQNECKSPCKWHNDAENKKCTLDKEEAKKVADETAKDGKTGNTNTTGSSNSFVISKTPLWLAVLLF,positive +GGGAGCTCAGAATAAACGCTCAAGGGTTGGGTGGGGAGGTTGTAGAATGCAGGGGTTCGACATGAGGCCCGGATC,MLNQLDNLTERVRGSNKLVDRWLHVRKHLLVAYYNLVGIKPGKESYMRLNEKALDDFCQSLVDYLSAGHFSIYERILHKLEGNGQLARAAKIWPQLEANTQQIMDYYDSSLETAIDHDNYLEFQQVLSDIGEALEARFVLEDKLILLVLDAARVKHPA,positive +TCCCACGCATTCTCCACATCCGCACGAGCATCGTACTTCCGTTATGATCATGAGACACAGCCTTTCTGTCCTTCCGTCAC,MSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA,positive +UCGUGU,PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKNSKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNRKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFYTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQK,positive +CCAAGCAUCAGCUGG,MASNFTQFVLVDNGGTGDVTVAPSNFANGVAEWISSNSRSQAYKVTCSVRQSSAQNRKYTIKVEVPKVATQTVGGVELPVAAWRSYLNMELTIPIFATNSDCELIVKAMQGLLKDGNPIPSAIAANSGIY,positive +GGTTGGTTTGGTTGG,ASFTCLAIWALASAGVVPLVLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAAFFFVPVIISTVCYVSIIRCLSSSAVANRSKK,positive +GGGAGCTCAGAATAAACGCTCAAGGTGGTGGGCGGGGTGTAGAATTGGAAGGGATTCGACATGAGGCCCGGATC,MLNQLDNLTERVRGSNKLVDRWLHVRKHLLVAYYNLVGIKPGKESYMRLNEKALDDFCQSLVDYLSAGHFSIYERILHKLEGNGQLARAAKIWPQLEANTQQIMDYYDSSLETAIDHDNYLEFQQVLSDIGEALEARFVLEDKLILLVLDAARVKHPA,positive +ACUAGCCUCAUCAGCUCAUGUGCCCCUCCGCCUGGAUCAC,MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYTFLLPEMDNCRSSSSPYVSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQDNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVLVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF,positive +TGCAGATGCAAGGTAACCATATCCAAAGCA,MDKFWWHAAWGLCLVPLSLAQIDLNITCRFAGVFHVEKNGRYSISRTEAADLCKAFNSTLPTMAQMEKALSIGFETCRYGFIEGHVVIPRIHPNSICAANNTGVYILTSNTSQYDTYCFNASAPPEEDCTSVTDLPNAFDGPITITIVNRDGTRYVQKGEYRTNPEDIYPSNPTDDDVSSGSSSERSSTSGGYIFYTFSTVHPIPDEDSPWITDSTDRIPATTLMSTSATATETATKRQETWDWFSWLFLPSESKNHLHTTTQMAGTSSNTISAGWEPNEENEDERDRHLSFSGSGIDDDEDFISSTISTTPRAFDHTKQNQDWTQWNPSHSNPEVLLQTTTRMTDVDRNGTTAYEGNWNPEAHPPLIHHEHHEEEETPHSTSTIQATPSSTTEETATQKEQWFGNRWHEGYRQTPKEDSHSTTGTAAASAHTSHPMQGRTTPSPEDSSWTDFFNPISHPMGRGHQAGRRMDMDSSHSITLQPTANPNTGLVEDLDRTGPLSMTTQQSNSQSFSTSHEGLEEDKDHPTTSTLTSSNRNDVTGGRRDPNHSEGSTTLLEGYTSHYPHTKESRTFIPVTSAKTGSFGVTAVTVGDSNSNVNRSLSGDQDTFHPSGGSHTTHGSESDGHSHGSQEGGANTTSGPIRTPQIPEWLIILASLLALALILAVCIAVNSRRRCGQKKKLVINSGNGAVEDRKPSGLNGEASKSQEMVHLVNKESSETPDQFMTADETRNLQNVDMKIGV,positive +CAAUCUCCCUACCCGCUUCAAUCUUCCCCCUUCCUACCU,MGVLLTQRTLLSLVLALLFPSMASMAAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQGLDVPKLREHCRERPGAFPSEETLRGLGRRGFLQTLNATLGCVLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILGLRNNIYCMAQLLDNSDTAEPTKAGRGASQPPTPTPASDAFQRKLEGCRFLHGYHRFMHSVGRVFSKWGESPNRSRRHSPHQALRKGVRRTRPSRKGKRLMTRGQLPR,positive +AGTTTGGCGGGTAGTGGATATCAAGACTATTTGATGCCGA,MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQRGLKNVFDEAILAALEPPETQPKRKCCIF,positive +GGATGATGCCGCACTGACGACACGTAGGTGGCGCACAGCC,MPSNQEARLFLAVLVLAQVLPILVDSAAEKGFKQAFWQPLCQVSEELDDQPKGALFTLQAAASKIQKMRDAALRASIYAEINHGTNRAKAAVIVANHYAMKADSGLEALKQTLSSQEVTATATASYLKGRIDEYLNLLLQTKESGTSGCMMDTSGTNTVTKAGGTIGGVPCKLQLSPIQPKRPAATYLGKAGYVGLTRQADAANNFHDNDAECRLASGHNTNGLGKSGQLSAAVTMAAGYVTVANSQTAVTVQALDALQEASGAAHQPWIDAWKAKKALTGAETAEFRNETAGIAGKTGVTKLVEEALLKKKDSEASEIQTELKKYFSGHENEQWTAIEKLISEQPVAQNLVGDNQPTKLGELEGNAKLTTILAYYRMETAGKFEVLTQKHKPAESQQQAAETEGSCNKKDQNECKSPCKWHNDAENKKCTLDKEEAKKVADETAKDGKTGNTNTTGSSNSFVISKTPLWLAVLLF,positive +GAAUCAAUACACAGUCCUGGGUGCUAACCAUGAACACCCAAGGCCUUAGUGGUGUGUGGUCCCUG,MAGRSGDSDEELLKAVRLIKFLYQSNPPPNPEGTRQARRNRRRRWRERQRQIHSISERILSTYLGRSAEPVPLQLPPLERLTLDCNEDCGTSGTQGVGSPQILVESPTILESGAKE,positive +GUCAAGUGCACACCCUUGCUCGUUUCUCGAUCGCCACAACCGAUUCCAAG,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,positive +ATAACACGACATCCATATGTCAGTGGTCTGTGTACGTACACGGTATTCGC,MKRASAGGSRLLAWVLWLQAWQVAAPCPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDNPWVCDCRARPLWAWLQKFRGSSSEVPCSLPQRLAGRDLKRLAANDLQGCAVATGPYHPIWTGRATDEEPLGLPKCCQPDAADKASVLEPGRPASAGNALKGRVPPGDSPPGNGSGPRHINDSPFGTLPGSAEPPLTAVRPEGSEPPGFPTSGPRRRPGCSRKNRTRSHCRLGQAGSGGGGTGDSEGSGALPSLTCSLTPLGLALVLWTVLGPC,positive +TCCCACGCATTCTCCACATCTAGTCTGGTTACGGTCTCGATTGTCCCAAAAGGGCAGACACCTTTCTGTCCTTCCGTCAC,MSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA,positive +CCCAGCGGACGCCTCATGCCGAGTAGCC,MVMGLGVLLLVFVLGLGLTPPTLAQDNSRYTHFLTQHYDAKPQGRDDRYCESIMRRRGLTSPCKDINTFIHGNKRSIKAICENKNGNPHRENLRISKSSFQVTTCKLHGGSPWPPCQYRATAGFRNVVVACENGLPVHLDQSIFRRP,positive +GCAGAACCACCCCCUUCCAUCACUCCAGCC,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,positive +GGGACACAAUGGACGACUCACUAUUUGUUUUCGCGCCCAGUUGCAAAAAGUGUCGUAACGGCCGACAUGAGAG,PHITDVVLDKANKTPLRQLDPSRLPDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFAKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRQSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPINRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDTASEATRPATLNRFSALQQTLPAENTDNRRVVQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRTRTPATKRSFSKEVEERSRERPSQPEGLRKAASLTEDRGRDPVKREATLPPVSPPKAALSVDEVEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRLGIESTLERSTIAREHMGRLLHQLLCAGHLSTAQYYQGLYETLELAEDMEIDIPHVWLYLAELITPILQEDGVPMGELFREITKPLRPMGKATSLLLEILGLLCKSMGPKKVGMLWREAGLSWREFLAEGQDVGSFVAEKKVEYTLGEESEAPGQRTLAFEELRRQLEKLLKDGGSNQRVFDWIDANLNEQQIASNTLVRALMTTVCYSAIIFETPLRVDVQVLKVRARLLQKYLCDEQKELQALYALQALVVTLEQPANLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFNWLREAEDEESDHN,positive +GGAGUCUUAGGCAGCGCGUUUUCGAGCUACUCCA,MGCRRTREGPSKAMIFPWKCQSTQRDLWNIFKLWGWTMLCCDFLAHHGTDCWTYHYSEKPMNWQRARRFCRDNYTDLVAIQNKAEIEYLEKTLPFSRSYYWIGIRKIGGIWTWVGTNKSLTEEAENWGDGEPNNKKNKEDCVEIYIKRNKDAGKWNDDACHKLKAALCYTASCQPWSCSGHGECVEIINNYTCNCDVGYYGPQCQFVIQCEPLEAPELGTMDCTHPLGNFSFSSQCAFSCSEGTNLTGIEETTCGPFGNWSSPEPTCQVIQCEPLSAPDLGIMNCSHPLASFSFTSACTFICSEGTELIGKKKTICESSGIWSNPSPICQKLDKSFSMIKEGDYNPLFIPVAVMVTAFSGLAFIIWLARRLKKGM,positive +AATACCCCCCCTTCGGTGCAAAGCACCGAAGGGGGGG,WPLTEEKIKALVEICXEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEEFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDXIIYQYMDDLYVGSDLEIGQHRTKVEELRQHLLXWGFTTPDKKHQKEPPFLWMGYELHP,positive +GGUUGGGUUGUCGUAGAUAUAGCUUAGCCA,MSKRKAPQETLNGGITDMLVELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVTGIGPSAARKLVDEGIKTLEDLRKNEDKLNHHQRIGLKYFEDFEKRIPREEMLQMQDIVLNEVKKLDPEYIATVCGSFRRGAESSGDMDVLLTHPNFTSESSKQPKLLHRVVEQLQKVRFITDTLSKGETKFMGVCQLPSENDENEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEQDIFDYIQWRYREPKDRSE,positive +TGTATCGTATTTGGTGATGTTTGGTGTTCA,MDKLVVNYYEYKHPIINKDLAIGAHGGKKFPTLGAWYDVINEYEFQTRCPIILKNSHRNKHFTFACHLKNCPFKVLLSYAGNAASSETSSPSANNNTNPPGTPDHIHHHSNNMNNEDNDNNNGSNNKVSNDSKLDFVTDDLEYHLANTHPDDTNDKVESRSNEVNGNNDDDADANNIFKQQGVTIKNDTEDDSINKASIDRGLDDESGPTHGNDSGNHRHNEEDDVHTQMTKNYSDVVNDEDINVAIANAVANVDSQSNNKHDGKDDDATNNNDGQDNNTNNDHNNNSNINNNNVGSHGISSHSPSSIRDTSMNLDVFNSATDDIPGPFVVTKIEPYHSHPLEDNLSLGKFILTKIPKILQNDLKFDQILESSYNNSNHTVSKFKVSHYVEESGLLDILMQRYGLTAEDFEKRLLSQIARRITTYKARFVLKKKKMGEYNDLQPSSSSNNNNNNDGELSGTNLRSNSIDYAKHQEISSAGTSSNTTKNVNNNKNDSNDDNNGNNNNDASNLMESVLDKTSSHRYQPKKMPSVNKWSKPDQITHSDVSMVGLDESNDGGNENVHPTLAEVDAQEARETAQLAIDKINSYKRSIDDKNGDGHNNSSRNVVDENLINDMDSEDAHKSKRQHLSDITLEERNEDDKLPHEVAEQLRLLSSHLKEVENLHQNNDDDVDDVMVDVDVESQYNKNTTHHNNHHSQPHHDEEDVAGLIGKADDEEDLSDENIQPELRGQ,positive +UUGUAAGCUCAACGGGUGGAGGGANCGGGCGAACGGGCUGGAGCACUACAAGCUUCUGGACUCGGU,MASTSRLDALPRVTCPNHPDAILVEDYRAGDMICPECDRVIDVGSEWRTFSNDKATKDPSRVGDSQNPLLSDGDLSTMIGKGTGAASFDEFGNSKYQNRRTMSSSDRAMMNAFKEITTMADRINLPRNIVDRTNNLFKQVYEQKSLKGRANDAIASACLYIACRQEGVPRTFKEICAVSRISKKEIGRCFKLILKALETSVDLITTGDFMSRFCSNLCLPKQVQMAATHIA,positive +GGCGACCCCCGGGCTACCAGACAATGTACGCAGCAAGAGTGACGGTCGTACCTCGGAGTC,MKKTLIALAIAASAASGMAHAWMTGDFNGSVDIGGSITADDYRQKWEWKVGTGLNGFGNVLNDLTNGGTKLTITVTGNKPILLGRTKEAFATPVTGGVDGIPHIAFTDYEGASVVLRNPDGETNKKGLAYFVLPMKNAEGTKVGSVKVNASYAGVLGRGGVTSADGELLSLFADGLSSIFYGGLPRGSELSAGSAAAARTKLFGSLSRNDILGQIQRVNANITSLVDVAGSYRENMEYTDGTVVSAAYALGIANGQTIEATFNQAVTTSTQWSAPLNVAITYY,positive +GUAUAUGUAUGUGUUGUUUUAUUGUGUGUGUGUGU,MAWYWWRRRRRRGWWKPRRRRWRRRRARRRGPARRHRARRRIVRHPCNGQTSSGNRVPRSVQAVDPKYVSLQLVWHSWDFRRGLFGQAGIKRMQQESDALTLSPVHRPKRPKRDTQVKEKTPEKDSDSAVQLRRLQPWIHSSQETKDEEEEIPEGPVQEQLLQQLQQQRLLRVQLESIAQEVLKIRRGHSLHPLLSSHA,positive +GGGAAAAGAGACGGCCGGCGCCAUAGCCGAGAUCCGAGGUGUUGA,MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC,positive +CACUACCACGCCAUAUCAGCUAAUGGCCCCUCCCUACGCA,MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYTFLLPEMDNCRSSSSPYVSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQDNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVLVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF,positive +CTTCTGCCCGCCTCCTTCCGTAAGTTATTTTCCTCGCGTTGTATGATGGAATTGACTCGGAGACGAGATAGGCGGACACT,MEGMLKGEGPGPLPPLLQQYVELRDQYPDYLLLFQVGDFYECFGEDAERLARALGLVLTHKTSKDFTTPMAGIPLRAFEAYAERLLKMGFRLAVADQVEPAEEAEGLVRREVTQLLTPGTLLQESLLPREANYLAAIATGDGWGLAFLDVSTGEFKGTVLKSKSALYDELFRHRPAEVLLAPELLENGAFLDEFRKRFPVMLSEAPFEPEGEGPLALRRARGALLAYAQRTQGGALSLQPFRFYDPGAFMRLPEATLRALEVFEPLRGQDTLFSVLDETRTAPGRRLLQSWLRHPLLDRGPLEARLDRVEGFVREGALREGVRRLLYRLADLERLATRLELGRASPKDLGALRRSLQILPELRALLGEEVGLPDLSPLKEELEAALVEDPPLKVSEGGLIREGYDPDLDALRAAHREGVAYFLELEERERERTGIPTLKVGYNAVFGYYLEVTRPYYERVPKEYRPVQTLKDRQRYTLPEMKEKEREVYRLEALIRRREEEVFLEVRERAKRQAEALREAARILAELDVYAALAEVAVRYGYVRPRFGDRLQIRAGRHPVVERRTEFVPNDLEMAHELVLITGPNMAGKSTFLRQTALIALLAQVGSFVPAEEAHLPLFDGIYTRIGASDDLAGGKSTFMVEMEEVALILKEATENSLVLLDEVGRGTSSLDGVAIATAVAEALHERRAYTLFATHYFELTALGLPRLKNLHVAAREEAGGLVFYHQVLPGPASKSYGVEVAAMAGLPKEVVARARALLQAMAARREGALDAVLERLLALDPDRLTPLEALRLLQELKALALGAPLDTMKG,positive +UCACUCUAUACCUCAAACGAAGUUGCACAACCCC,MAVAQELYGFPASKLDSFVAQWLQPTREWKEEVLETVQTVEQFLRQENFREDRGPARDVRVLKVLKVGCFGNGTVLRSTTDVELVVFLSCFHSFQEEAKHHQAVLRLIQKRMYYCQELMDLGLSNLSVTNRVPSSLIFTIQTRETWETITVTVVPAYRALGPSCPSSEVYANLIKANGYPGNFSPSFSELQRNFVKHRPTKLKSLLRLVKHWYQQYVRDKCPRANLPPLYALELLTVYAWEAGTREDANFRLDEGLATVMELLQDHELLCIYWTKHYTLQHPVIEACVRRQLRGQRPIILDPADPTNNVAEGYRWDIVAQRANQCLKQDCCYDNRDSPVPSWRVKRAPDIQVTVQEWGHSDLTFWVNPYEPIKKLKEKIQLSQGYLGLQRLSFQEPGGERQLIRSHCTLAYYGIFCDTHICLLDTISPEIQVFVKNPDGRSHAYAIHPLDYVLNLKQQIEDRQGLRCQEQRLEFQGHILEDWFDFKSYGIQDSVTVILSKTTEGAAPFVPS,positive +UCACCUGUACACUACCUCUACCAUGCUUGAGCCUACGCCGCCGACACCC,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,positive +AUUCGGGCCCAGGAACCAACUAUAUAAAUGUCCCGAAUGCUUCGACG,MPFVNKQFNYKDPVNGVDIAYIKIPNVGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAGHRLYGIAINPNRVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNRKTYLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLKNFTGLFEFYKLLCVRGIITSKTKSLDKGYNKALNDLCIKVNNWDLFFSPSEDNFTNDLNKGEEITSDTNIEAAEENISLDLIQQYYLTFNFDNEPENISIENLSSDIIGQLELMPNIERFPNGKKYELDKYTMFHYLRAQEFEHGKSRIALTNSVNEALLNPSRVYTFFSSDYVKKVNKATEAAMFLGWVEQLVYDFTDETSEVSTTDKIADITIIIPYIGPALNIGNMLYKDDFVGALIFSGAVILLEFIPEIAIPVLGTFALVSYIANKVLTVQTIDNALSKRNEKWDEVYKYIVTNWLAKVNTQIDLIRKKMKEALENQAEATKAIINYQYNQYTEEEKNNINFNIDDLSSKLNESINKAMININKFLNQCSVSYLMNSMIPYGVKRLEDFDASLKDALLKYIYDNRGTLIGQVDRLKDKVNNTLSTDIPFQLSKYVDNQRLLSTFTEYIKNIINTSILNLRYESNHLIDLSRYASKINIGSKVNFDPIDKNQIQLFNLESSKIEVILKNAIVYNSMYENFSTSFWIRIPKYFNSISLNNEYTIINCMENNSGWKVSLNYGEIIWTLQDTQEIKQRVVFKYSQMINISDYINRWIFVTITNNRLNNSKIYINGRLIDQKPISNLGNIHASNNIMFKLDGCRDTHRYIWIKYFNLFDKELNEKEIKDLYDNQSNSGILKDFWGDYLQYDKPYYMLNLYDPNKYVDVNNVGIRGYMYLKGPRGSVMTTNIYLNSSLYRGTKFIIKKYASGNKDNIVRNNDRVYINVVVKNKEYRLATNASQAGVEKILSALEIPDVGNLSQVVVMKSKNDQGITNKCKMNLQDNNGNDIGFIGFHQFNNIAKLVASNWYNRQIERSSRTLGCSWEFIPVDDGWGERPL,positive +GGACCUUUGUACCCCAGAUGAUAGUAAGGCGCGGCUUGAUGGGUACAAAUGGCAG,MIPPPRRSASSTPKDYRSSRDLQPWRGVSSGDAAETSQQSRHRRDAIADGGGRLKGAAQSSPSSGTRRSGPYAQGRAMPKNENIPKPGKQRLGPRKKKLSTLKKKILLDRLERWRDKQHEGALSTPSATASSEEAKCNNPFPLCPPGELSPPPSPPATICPAVVDKSTSYGQVGGANGERSVWAITIYNLVDQEDVEDDDDHAEIERDLWDMSSAFGVVRSVQVPRGTAVQVSDAEVSAAAAAGEPAAVAAKVAFATNAEAECARDGLNGRIVGGKPLLVRIHRCDGHFCGGVCPGDPDGSGLWRVAIENLIDEEDDLDDEDEYAEISANVSAMMGCYGKLVDVQVRRSSPSKGEVQEDVATRAATTAGATQAVVVTFGSLAEAEACVQGIKGCRVGGKELDAHVVLDSERVLPSNPAFKCDQEHAHSSDVAAAVAGQGDSMMKQEAGTEPSPCVDQDTAAAVASSTEWRVVIRGLIDEDDLQDDDDDYAEVCSDVTALVSSYGAVVGLDIPRGRETGSCCYGAEPGEAVVVFRSLQEAEACARGLSGRKVAGNILDAQVLTQPAPSQQGPLQGGASGTGPPVANRERKPAKECPLPQHQASSHQSCGKVPELDGSGPGMLRGFGNRVEDCCGRPKIACTDSDEPQAIAAAAPPGQSIEGPKTTALAKAGKRIQTKYQEAAALPKPPGVRGGLPNAYVNQPPDKEVNDLVFEMLQLLFKFQERARLSDPSKAKTRRRLVIGLREVLRGVKAKKVRLLIVAPNVDAVGGEGGLDDKVVEIIDKAREAEYPVVFALSKRKIGKALGKTIKVSAVGVYSFDGANEQQKQLKRRMETISSLPSPSPRQSDPPTDDALASPPSSSACGDSQDPAGKGSRV,positive +GGACAANNAGCGGUGUCUUUUCAUUUNNAUCCUCCGACNUCC,IMEIRTVAVGIVAIKGVESEYYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHSGGEMFVALNQKGLPVKGKKTKKEQKTAHFLPMAIT,positive +TCCTACGGCGCTAACGTACTAGCGAGGGTATGGTGTGGGAATGTCGCCACCGTGCTACAAC,VENLMVQELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFSHFRLFDENNDAAILILLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVN,positive +TCTGCTACGCTGAGTGGCTGTTTACCTTCGT,MGLLGILCFLIFLGKTWGQEQTYVISAPKIFRVGASENIVIQVYGYTEAFDATISIKSYPDKKFSYSSGHVHLSSENKFQNSAILTIQPKQLPGGQNPVSYVYLEVVSKHFSKSKRMPITYDNGFLFIHTDKPVYTPDQSVKVRVYSLNDDLKPAKRETVLTFIDPEGSEVDMVEEIDHIGIISFPDFKIPSNPRYGMWTIKAKYKEDFSTTGTAYFEVKEYVLPHFSVSIEPEYNFIGYKNFKNFEITIKARYFYNKVVTEADVYITFGIREDLKDDQKEMMQTAMQNTMLINGIAQVTFDSETAVKELSYYSLEDLNNKYLYIAVTVIESTGGFSEEAEIPGIKYVLSPYKLNLVATPLFLKPGIPYPIKVQVKDSLDQLVGGVPVTLNAQTIDVNQETSDLDPSKSVTRVDDGVASFVLNLPSGVTVLEFNVKTDAPDLPEENQAREGYRAIAYSSLSQSYLYIDWTDNHKALLVGEHLNIIVTPKSPYIDKITHYNYLILSKGKIIHFGTREKFSDASYQSINIPVTQNMVPSSRLLVYYIVTGEQTAELVSDSVWLNIEEKCGNQLQVHLSPDADAYSPGQTVSLNMATGMDSWVALAAVDSAVYGVQRGAKKPLERVFQFLEKSDLGCGAGGGLNNANVFHLAGLTFLTNANADDSQENDEPCKEILRPRRTLQKKIEEIAAKYKHSVVKKCCYDGACVNNDETCEQRAARISLGPRCIKAFTECCVVASQLRANISHKDMQLGRLHMKTLLPVSKPEIRSYFPESWLWEVHLVPRRKQLQFALPDSLTTWEIQGVGISNTGICVADTVKAKVFKDVFLEMNIPYSVVRGEQIQLKGTVYNYRTSGMQFCVKMSAVEGICTSESPVIDHQGTKSSKCVRQKVEGSSSHLVTFTVLPLEIGLHNINFSLETWFGKEILVKTLRVVPEGVKRESYSGVTLDPRGIYGTISRRKEFPYRIPLDLVPKTEIKRILSVKGLLVGEILSAVLSQEGINILTHLPKGSAEAELMSVVPVFYVFHYLETGNHWNIFHSDPLIEKQKLKKKLKEGMLSIMSYRNADYSYSVWKGGSASTWLTAFALRVLGQVNKYVEQNQNSICNSLLWLVENYQLDNGSFKENSQYQPIKLQGTLPVEARENSLYLTAFTVIGIRKAFDICPLVKIDTALIKADNFLLENTLPAQSTFTLAISAYALSLGDKTHPQFRSIVSALKREALVKGNPPIYRFWKDNLQHKDSSVPNTGTARMVETTAYALLTSLNLKDINYVNPVIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVKQLRLSMDIDVSYKHKGALHNYKMTDKNFLGRPVEVLLNDDLIVSTGFGSGLATVHVTTVVHKTSTSEEVCSFYLKIDTQDIEASHYRGYGNSDYKRIVACASYKPSREESSSGSSHAVMDISLPTGISANEEDLKALVEGVDQLFTDYQIKDGHVILQLNSIPSSDFLCVRFRIFELFEVGFLSPATFTVYEYHRPDKQCTMFYSTSNIKIQKVCEGAACKCVEADCGQMQEELDLTISAETRKQTACKPEIAYAYKVSITSITVENVFVKYKATLLDIYKTGEAVAEKDSEITFIKKVTCTNAELVKGRQYLIMGKEALQIKYNFSFRYIYPLDSLTWIEYWPRDTTCSSCQAFLANLDEFAEDIFLNGC,positive +CCCAACATCTACGGTTAGACCGGGTTTACCTGAGCTGACA,MKKRKVLIPLMALSTILVSSTGNLEVIQAEVKQENRLLNESESSSQGLLGYYFSDLNFQAPMVVTSSTTGDLSIPSSELENIPSENQYFQSAIWSGFIKVKKSDEYTFATSADNHVTMWVDDQEVINKASNSNKIRLEKGRLYQIKIQYQRENPTEKGLDFKLYWTDSQNKKEVISSDNLQLPELKQKSSNSRKKRSTSAGPTVPDRDNDGIPDSLEVEGYTVDVKNKRTFLSPWISNIHEKKGLTKYKSSPEKWSTASDPYSDFEKVTGRIDKNVSPEARHPLVAAYPIVHVDMENIILSKNEDQSTQNTDSQTRTISKNTSTSRTHTSEVHGNAEVHASFFDIGGSVSAGFSNSNSSTVAIDHSLSLAGERTWAETMGLNTADTARLNANIRYVNTGTAPIYNVLPTTSLVLGKNQTLATIKAKENQLSQILAPNNYYPSKNLAPIALNAQDDFSSTPITMNYNQFLELEKTKQLRLDTDQVYGNIATYNFENGRVRVDTGSNWSEVLPQIQETTARIIFNGKDLNLVERRIAAVNPSDPLETTKPDMTLKEALKIAFGFNEPNGNLQYQGKDITEFDFNFDQQTSQNIKNQLAELNATNIYTVLDKIKLNAKMNILIRDKRFHYDRNNIAVGADESVVKEAHREVINSSTEGLLLNIDKDIRKILSGYIVEIEDTEGLKEVINDRYDMLNISSLRQDGKTFIDFKKYNDKLPLYISNPNYKVNVYAVTKENTIINPSENGDTSTNGIKKILIFSKKGYEIG,positive +UCCAGGGAUUGAAGUGUCGGGGUAGGAACAUAAAGGCGGC,IMEIRTVAVGIVAIKGVESEYYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHSGGEMFVALNQKGLPVKGKKTKKEQKTAHFLPMAIT,positive +ACTCCAACGATCCCACCGCGACAAGGGTCATCGGCACCGT,MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP,positive +ATCGATGACCCGTAGTGCAGTGAATTACGT,MDKLVVNYYEYKHPIINKDLAIGAHGGKKFPTLGAWYDVINEYEFQTRCPIILKNSHRNKHFTFACHLKNCPFKVLLSYAGNAASSETSSPSANNNTNPPGTPDHIHHHSNNMNNEDNDNNNGSNNKVSNDSKLDFVTDDLEYHLANTHPDDTNDKVESRSNEVNGNNDDDADANNIFKQQGVTIKNDTEDDSINKASIDRGLDDESGPTHGNDSGNHRHNEEDDVHTQMTKNYSDVVNDEDINVAIANAVANVDSQSNNKHDGKDDDATNNNDGQDNNTNNDHNNNSNINNNNVGSHGISSHSPSSIRDTSMNLDVFNSATDDIPGPFVVTKIEPYHSHPLEDNLSLGKFILTKIPKILQNDLKFDQILESSYNNSNHTVSKFKVSHYVEESGLLDILMQRYGLTAEDFEKRLLSQIARRITTYKARFVLKKKKMGEYNDLQPSSSSNNNNNNDGELSGTNLRSNSIDYAKHQEISSAGTSSNTTKNVNNNKNDSNDDNNGNNNNDASNLMESVLDKTSSHRYQPKKMPSVNKWSKPDQITHSDVSMVGLDESNDGGNENVHPTLAEVDAQEARETAQLAIDKINSYKRSIDDKNGDGHNNSSRNVVDENLINDMDSEDAHKSKRQHLSDITLEERNEDDKLPHEVAEQLRLLSSHLKEVENLHQNNDDDVDDVMVDVDVESQYNKNTTHHNNHHSQPHHDEEDVAGLIGKADDEEDLSDENIQPELRGQ,positive +GGGAGAAUUCAACUGCCAUCUAGGCGCUAGUAGCCUCAGCAGCAUAGUUUCGCCGCUAUGCAGUAAGUACUACAAGCUUCUGGACUCGGU,MNRPHSCLSFCWMYFAASGIRAVETANGKYAQKLFSDLFEDYSSALRPVEDTDAVLNVTLQVTLSQIKDMDERNQILTAYLWIRQTWHDAYLTWDRDQYDRLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDSPAITKSSCVVDVTYFPFDSQQCNLTFGSWTYNGNQVDIFNALDSGDLSDFIEDVEWEVHGMPAVKNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGEKVSLGVTILLAMTVFQLMVAEIMPASENVPLIGKYYIATMALITASTALTIMVMNIHFCGAEARPVPHWAKVVILKYMSRILFVYDVGESCLSPRHSQEPEQVTKVYSKLPESNLKTSRNKDLSRKKEVRKLLKNDLGYQGGIPQNTDSYCARYEALTKNIEYIAKCLKDHKATNSKGSEWKKVAKVIDRFFMWIFFAMVFVMTVLIIARAD,positive +GGGCCTCGATTTAGTTCGCGGCCATAGGGC,AKVLVVLLLFAGVDAETHVTGGSAAHAASTFAGLFSPGAKQDIQLINTNGSWHINRTA,positive +GGAGUCUUAGGCAGCGCGUUUUCGAGCUACUCCA,MGCRRTREGPSKAMIFPWKCQSTQRDLWNIFKLWGWTMLCCDFLAHHGTDCWTYHYSEKPMNWQRARRFCRDNYTDLVAIQNKAEIEYLEKTLPFSRSYYWIGIRKIGGIWTWVGTNKSLTEEAENWGDGEPNNKKNKEDCVEIYIKRNKDAGKWNDDACHKLKAALCYTASCQPWSCSGHGECVEIINNYTCNCDVGYYGPQCQFVIQCEPLEAPELGTMDCTHPLGNFSFSSQCAFSCSEGTNLTGIEETTCGPFGNWSSPEPTCQVIQCEPLSAPDLGIMNCSHPLASFSFTSACTFICSEGTELIGKKKTICESSGIWSNPSPICQKLDKSFSMIKEGDYNPLFIPVAVMVTAFSGLAFIIWLARRLKKGM,positive +TCCCTACGGCGCTAACTCCCGATAGGAGGCCCGTGGCCGTGTTATCGCCACCGTGCTACAAC,VENLMVQELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFSHFRLFDENNDAAILILLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVN,positive +UUCCAUUGGAGUGGAACUGAGUUC,MASNFTQFVLVDNGGTGDVTVAPSNFANGVAEWISSNSRSQAYKVTCSVRQSSAQNRKYTIKVEVPKVATQTVGGVELPVAAWRSYLNMELTIPIFATNSDCELIVKAMQGLLKDGNPIPSAIAANSGIY,positive +GCGACUGGUUACCCGGUCG,MAGPQALAFGLLLAVVTATLAAAQRDCVCDNYKLATSCSLNEYGECQCTSYGTQNTVICSKLASKCLAMKAEMTHSKSGRRIKPEGAIQNNDGLYDPDCDEQGLFKAKQCNGTATCWCVNTAGVRRTDKDTEITCSERVRTYWIIIELKHKERESPYDHQSLQTALQEAFTSRYKLNQKFIKNIMYENNVITIDLMQNSSQKTQDDVDIADVAYYFEKDVKGESLFHSSKSMDLRVNGEPLDLDPGQTLIYYVDEKAPEFSMQGLTAGIIAVIVVVSLAVIAGIVVLVISTRKKSAKYEKAEIKEMGEIHRELNA,positive +UAAGCUCUUUGGCUUAGCCCGACACGUUGAACUCCAGAGU,MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYTFLLPEMDNCRSSSSPYVSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQDNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVLVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF,positive +UGCACGGAAAUGCAGAAGGCGUGGUCCGUGGGAGGCGACAAGCAUCAAUG,MDSTNYISKLFEYAQRQGQISDIKFEEVGTDGPDHLKTFTLRVVIKGHAYPNGVGKTKKEAKRNAAKHALIGMMETTEQKDASVSCPPSPAPSPAPPVRAVISQPKYVSWLNEHSQKNKLSLKALEGARVGPNNTSQCCRYVVGEKEYPEGFGNTKKEAKEEAAMQVYLELCGGSQTTGTVDENCNGTTGKHKEELNGKVVVLSEKVEHMNMSPAQNVPEQYSFITTEETNFIGILNHYCQKTKRFLDFKLVEKSGPSHNPQFVYKVLIDKREYPDGLGKTAKEAKQQAAQLAWSALQEQSDWNSQVSCRSTVSEEGGLSSLTPSSTWESQDATPSSLSIAGSTSESIIFSDSVNVSSPKDESPVNVKPKIRLAANFQMSPVKTKQEGPNLKGNDLGTLSSGRTSNQPVISRFSSEFDSIENIGKGGFGHVYKARRKLEQKYFAVKIVRSKGKAKREVGALADLQHPNIVRYYTAWLEDTAYRCDTASESDTTSDSGSSSSSEFLYIQMELCDKRTLKVWIDERNAHRKPKRREESLSITQQIVNGVEYIHSKKLLHRDLKPANIMFGMSDGEGKGEVKIGDFGLVTAEDNDNDENLLERTKKTGTVSYMAPEQRNQTSYDRKVDIFALGLIYFEPLWDLSGMEKAKVWNDVRSQRFPQQFNSQFTLENKVIESLLCANPEERPDARQLKTKLNECSRVLTRVHNIHQDNRTI,positive +CAUAGGCUUACAACAGAGCGGGGGUUCUGAUGGUAGACGCCGGGACGCCC,MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPGPHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR,positive +GCGCAGGCGGGGTTTGACTTCGAGGCCG,MVMGLGVLLLVFVLGLGLTPPTLAQDNSRYTHFLTQHYDAKPQGRDDRYCESIMRRRGLTSPCKDINTFIHGNKRSIKAICENKNGNPHRENLRISKSSFQVTTCKLHGGSPWPPCQYRATAGFRNVVVACENGLPVHLDQSIFRRP,positive +ATGGCTGTGGTGGAGGGCCGAAGCCTGTACAAAACAGGAATGCGCTTATCTTGGAGTAT,MRKIVVAAIAVSLTTVSITASASADPSKDSKAQVSAAEAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKVKPSAASIDAAKKAGVNNGNPLDAVQQ,positive +GGGAGAATTCCGACCAGAAGGCTTGCTGTTGTTTCCCTGTTGTTTTGTCTCTCAACTTTATTGTGGTAAAGATCACTGGGTTGATAAGGGCTAACTCTAATTTGACTACATGGTCGGACCAATCAGTTCTTATGGGAGATGCATATGTGCGTCTACATGGATCCTCA,VFTDNSSPPAVPQSFQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGFGAYMSKAHGVDPNIRTGVRTITTGSPITYSTYGKFLADGGCSGGAYDIIICDECHSTDATSILGIGTVLDQAETAGARLVVLATATPPGSVTVSHPNIEEVALSTTGEIPFYGKAIPLEVIKGGRHLIFCHSKKKCDELAAKLVALGINAVAYYRGLDVSVIPTSGDVVVVSTDALMTGFTGDFDSVIDCNTCVTQTVDFSLDPTFTIETTTLPQDAVSRTQRRGRTGRGKPGIYRFVAPGERPSGMFDSSVLCECYDAGCAWYELTPAETTVRLRAYMNTPGLPVCQDHLEFWEGVFTGLTHIDAHFLSQTKQSGENFPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPTLHGPTPLLYRLGAVQNEVT,positive +GGGACACAATGGACGUGCGCATAGGAAUUGCUCUCAAAAAACUGGACAAAAUAAUUUACGGCCGAACGCUUGCUCCGCCCUCUCUCAUAACGGCCGACAUGAGAG,PHITDVVLDKANKTPLRQLDPSRLPDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFAKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRQSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPINRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDTASEATRPATLNRFSALQQTLPAENTDNRRVVQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRTRTPATKRSFSKEVEERSRERPSQPEGLRKAASLTEDRGRDPVKREATLPPVSPPKAALSVDEVEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRLGIESTLERSTIAREHMGRLLHQLLCAGHLSTAQYYQGLYETLELAEDMEIDIPHVWLYLAELITPILQEDGVPMGELFREITKPLRPMGKATSLLLEILGLLCKSMGPKKVGMLWREAGLSWREFLAEGQDVGSFVAEKKVEYTLGEESEAPGQRTLAFEELRRQLEKLLKDGGSNQRVFDWIDANLNEQQIASNTLVRALMTTVCYSAIIFETPLRVDVQVLKVRARLLQKYLCDEQKELQALYALQALVVTLEQPANLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFNWLREAEDEESDHN,positive +GGGAGCTCAGAATAAACGCTCAATCGGTGGGCGGGTGGGGTGGTTGCAGAATGAATTCGACATGAGGCCCGGATC,MLNQLDNLTERVRGSNKLVDRWLHVRKHLLVAYYNLVGIKPGKESYMRLNEKALDDFCQSLVDYLSAGHFSIYERILHKLEGNGQLARAAKIWPQLEANTQQIMDYYDSSLETAIDHDNYLEFQQVLSDIGEALEARFVLEDKLILLVLDAARVKHPA,positive +ACUGGCUAGCUAACCAAUGGUGGAUAUGAGUACCUUGGGC,LQENFLPQPRQQHHGTLVLHYRPHREEAGMQHPCLWPGSSHCSDDSTLRRLQCESVTSIGAVCP,positive +TATTAGTAATACTATTAGTAATAC,MDHLNEATQGKEHSEMSNNVSDPKGPPAKIARLEQNGSPLGRGRLGSTGAKMQGVPLKHSGHLMKTNLRKGTMLPVFCVVEHYENAIEYDCKEEHAEFVLVRKDMLFNQLIEMALLSLGYSHSSAAQAKGLIQVGKWNPVPLSYVTDAPDATVADMLQDVYHVVTLKIQLHSCPKLEDLPPEQWSHTTVRNALKDLLKDMNQSSLAKECPLSQSMISSIVNSTYYANVSAAKCQEFGRWYKHFKKTKDMMVEMDSLSELSQQGANHVNFGQQPVPGNTAEQPPSPAQLSHGSQPSVRTPLPNLHPGLVSTPISPQLVNQQLVMAQLLNQQYAVNRLLAQQSLNQQYLNHPPPVSRSMNKPLEQQVSTNTEVSSEIYQWVRDELKRAGISQAVFARVAFNRTQGLLSEILRKEEDPKTASQSLLVNLRAMQNFLQLPEAERDRIYQDERERSLNAASAMGPAPLISTPPSRPPQVKTATIATERNGKPENNTMNINASIYDEIQQEMKRAKVSQALFAKVAATKSQGWLCELLRWKEDPSPENRTLWENLSMIRRFLSLPQPERDAIYEQESNAVHHHGDRPPHIIHVPAEQIQQQQQQQQQQQQQQQAPPPPQPQQQPQTGPRLPPRQPTVASPAESDEENRQKTRPRTKISVEALGILQSFIQDVGLYPDEEAIQTLSAQLDLPKYTIIKFFQNQRYYLKHHGKLKDNSGLEVDVAEYKEEELLKDLEESVQDKNTNTLFSVKLEEELSVEGNTDINTDLKD,positive +GCAAUGACCAAGGUACCGACCCUAUGGCUCCGGCCUGCGU,MGVLLTQRTLLSLVLALLFPSMASMAAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQGLDVPKLREHCRERPGAFPSEETLRGLGRRGFLQTLNATLGCVLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILGLRNNIYCMAQLLDNSDTAEPTKAGRGASQPPTPTPASDAFQRKLEGCRFLHGYHRFMHSVGRVFSKWGESPNRSRRHSPHQALRKGVRRTRPSRKGKRLMTRGQLPR,positive +TATTAGCAACAATATTAGCAACAA,MDHLNEATQGKEHSEMSNNVSDPKGPPAKIARLEQNGSPLGRGRLGSTGAKMQGVPLKHSGHLMKTNLRKGTMLPVFCVVEHYENAIEYDCKEEHAEFVLVRKDMLFNQLIEMALLSLGYSHSSAAQAKGLIQVGKWNPVPLSYVTDAPDATVADMLQDVYHVVTLKIQLHSCPKLEDLPPEQWSHTTVRNALKDLLKDMNQSSLAKECPLSQSMISSIVNSTYYANVSAAKCQEFGRWYKHFKKTKDMMVEMDSLSELSQQGANHVNFGQQPVPGNTAEQPPSPAQLSHGSQPSVRTPLPNLHPGLVSTPISPQLVNQQLVMAQLLNQQYAVNRLLAQQSLNQQYLNHPPPVSRSMNKPLEQQVSTNTEVSSEIYQWVRDELKRAGISQAVFARVAFNRTQGLLSEILRKEEDPKTASQSLLVNLRAMQNFLQLPEAERDRIYQDERERSLNAASAMGPAPLISTPPSRPPQVKTATIATERNGKPENNTMNINASIYDEIQQEMKRAKVSQALFAKVAATKSQGWLCELLRWKEDPSPENRTLWENLSMIRRFLSLPQPERDAIYEQESNAVHHHGDRPPHIIHVPAEQIQQQQQQQQQQQQQQQAPPPPQPQQQPQTGPRLPPRQPTVASPAESDEENRQKTRPRTKISVEALGILQSFIQDVGLYPDEEAIQTLSAQLDLPKYTIIKFFQNQRYYLKHHGKLKDNSGLEVDVAEYKEEELLKDLEESVQDKNTNTLFSVKLEEELSVEGNTDINTDLKD,positive +UUAACUCCCAACGCAUCAAUCCCGAUCCGUGACUCCGCC,MGVLLTQRTLLSLVLALLFPSMASMAAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQGLDVPKLREHCRERPGAFPSEETLRGLGRRGFLQTLNATLGCVLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILGLRNNIYCMAQLLDNSDTAEPTKAGRGASQPPTPTPASDAFQRKLEGCRFLHGYHRFMHSVGRVFSKWGESPNRSRRHSPHQALRKGVRRTRPSRKGKRLMTRGQLPR,positive +CTTGCAAAATTTGCAACTGTGTG,MSDRKKIEIDAIDKKLLIELLKDSRISLRRLAEEMNVSPATLHNRLMRLVQEGVVKGFTALIDYSKLGYPVTSILMIKVDGKHILEFEKEVSNLDNVVAVYDVVGEYDVMLIAKFRSIEDLDTFIKSLLKNPKIERTYTSIVLNVVKEDPRIKII,positive +GGAATAGAGACAAAGCCACTCATATGAGT,MKKRKVLIPLMALSTILVSSTGNLEVIQAEVKQENRLLNESESSSQGLLGYYFSDLNFQAPMVVTSSTTGDLSIPSSELENIPSENQYFQSAIWSGFIKVKKSDEYTFATSADNHVTMWVDDQEVINKASNSNKIRLEKGRLYQIKIQYQRENPTEKGLDFKLYWTDSQNKKEVISSDNLQLPELKQKSSNSRKKRSTSAGPTVPDRDNDGIPDSLEVEGYTVDVKNKRTFLSPWISNIHEKKGLTKYKSSPEKWSTASDPYSDFEKVTGRIDKNVSPEARHPLVAAYPIVHVDMENIILSKNEDQSTQNTDSQTRTISKNTSTSRTHTSEVHGNAEVHASFFDIGGSVSAGFSNSNSSTVAIDHSLSLAGERTWAETMGLNTADTARLNANIRYVNTGTAPIYNVLPTTSLVLGKNQTLATIKAKENQLSQILAPNNYYPSKNLAPIALNAQDDFSSTPITMNYNQFLELEKTKQLRLDTDQVYGNIATYNFENGRVRVDTGSNWSEVLPQIQETTARIIFNGKDLNLVERRIAAVNPSDPLETTKPDMTLKEALKIAFGFNEPNGNLQYQGKDITEFDFNFDQQTSQNIKNQLAELNATNIYTVLDKIKLNAKMNILIRDKRFHYDRNNIAVGADESVVKEAHREVINSSTEGLLLNIDKDIRKILSGYIVEIEDTEGLKEVINDRYDMLNISSLRQDGKTFIDFKKYNDKLPLYISNPNYKVNVYAVTKENTIINPSENGDTSTNGIKKILIFSKKGYEIG,positive +GGAGGCGCGATGTAGGTATGTGAGGGCGGCGCGGTGGGCG,MKPGGNTIVIWMYAVATWLCFGSTSGWSFTLEDNNIFPKQYPIINFTTAGATVQSYTNFIRAVRGRLTTGADVRHEIPVLPNRVGLPINQRFILVELSNHAELSVTLALDVTNAYVVGYRAGNSAYFFHPDNQEDAEAITHLFTDVQNRYTFAFGGNYDRLEQLAGNLRENIELGNGPLEEAISALYYYSTGGTQLPTLARSFIICIQMISEAARFQYIEGEMRTRIRYNRRSAPDPSVITLENSWGRLSTAIQESNQGAFASPIQLQRRNGSKFSVYDVSILIPIIALMVYRCAPPPSSQFSLLIRPVVPNFNADVCMDPEPIVRIVGRNGLCVDVRDGRFHNGNAIQLWPCKSNTDANQLWTLKRDNTIRSNGKCLTTYGYSPGVYVMIYDCNTAATDATRWQIWDNGTIINPRSSLVLAATSGNSGTTLTVQTNIYAVSQGWLPTNNTQPFVTTIVGLYGLCLQANSGQVWIEDCSSEKAEQQWALYADGSIRPQQNRDNCLTSDSNIRETVVKILSCGPASSGQRWMFKNDGTILNLYSGLVLDVRASDPSLKQIILYPLHGDPNQIWLPLF,positive +GCAGUUAACCAAGCCUGCAUACUGGAUAGACGGCUUAUUUGACUGAAUGCCUCCCGAAAGGUGCAGUU,MAGRSGDSDEELLKAVRLIKFLYQSNPPPNPEGTRQARRNRRRRWRERQRQIHSISERILSTYLGRSAEPVPLQLPPLERLTLDCNEDCGTSGTQGVGSPQILVESPTILESGAKE,positive +AATATCCCCCCTTCGGTGCAAAGCACCGAAGGGGGGA,WPLTEEKIKALVEICXEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEEFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDXIIYQYMDDLYVGSDLEIGQHRTKVEELRQHLLXWGFTTPDKKHQKEPPFLWMGYELHP,positive +CCGTAGGTTCGGGGTCGGAGTGGTCCGGAAGGTGGCGTGG,MKPGGNTIVIWMYAVATWLCFGSTSGWSFTLEDNNIFPKQYPIINFTTAGATVQSYTNFIRAVRGRLTTGADVRHEIPVLPNRVGLPINQRFILVELSNHAELSVTLALDVTNAYVVGYRAGNSAYFFHPDNQEDAEAITHLFTDVQNRYTFAFGGNYDRLEQLAGNLRENIELGNGPLEEAISALYYYSTGGTQLPTLARSFIICIQMISEAARFQYIEGEMRTRIRYNRRSAPDPSVITLENSWGRLSTAIQESNQGAFASPIQLQRRNGSKFSVYDVSILIPIIALMVYRCAPPPSSQFSLLIRPVVPNFNADVCMDPEPIVRIVGRNGLCVDVRDGRFHNGNAIQLWPCKSNTDANQLWTLKRDNTIRSNGKCLTTYGYSPGVYVMIYDCNTAATDATRWQIWDNGTIINPRSSLVLAATSGNSGTTLTVQTNIYAVSQGWLPTNNTQPFVTTIVGLYGLCLQANSGQVWIEDCSSEKAEQQWALYADGSIRPQQNRDNCLTSDSNIRETVVKILSCGPASSGQRWMFKNDGTILNLYSGLVLDVRASDPSLKQIILYPLHGDPNQIWLPLF,positive +ATACCAGCTTATTCAATTCAAGTTGCTGTGGGACAGAAACGGGCGCTAGACTATGCATAGATAGTAAGTGCAATCT,MPFVNKQFNYKDPVNGVDIAYIKIPNAGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAGHRLYGIAINPNRVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNRKTYLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLKNFTGLFEFYKLLCVRGIITSKTKSLDKGYNKALNDLCIKVNNWDLFFSPSEDNFTNDLNKGEEITSDTNIEAAEENISLDLIQQYYLTFNFDNEPENISIENLSSDIIGQLELMPNIERFPNGKKYELDKYTMFHYLRAQEFEHGKSRIALTNSVNEALLNPSRVYTFFSSDYVKKVNKATEAAMFLGWVEQLVYDFTDETSEVSTTDKIADITIIIPYIGPALNIGNMLYKDDFVGALIFSGAVILLEFIPEIAIPVLGTFALVSYIANKVLTVQTIDNALSKRNEKWDEVYKYIVTNWLAKVNTQIDLIRKKMKEALENQAEATKAIINYQYNQYTEEEKNNINFNIDDLSSKLNESINKAMININKFLNQCSVSYLMNSMIPYGVKRLEDFDASLKDALLKYIYDNRGTLIGQVDRLKDKVNNTLSTDIPFQLSKYVDNQRLLSTFTEYIKNIINTSILNLRYESNHLIDLSRYASKINIGSKVNFDPIDKNQIQLFNLESSKIEVILKNAIVYNSMYENFSTSFWIRIPKYFNSISLNNEYTIINCMENNSGWKVSLNYGEIIWTLQDTQEIKQRVVFKYSQMINISDYINRWIFVTITNNRLNNSKIYINGRLIDQKPISNLGNIHASNNIMFKLDGCRDTHRYIWIKYFNLFDKELNEKEIKDLYDNQSNSGILKDFWGDYLQYDKPYYMLNLYDPNKYVDVNNVGIRGYMYLKGPRGSVMTTNIYLNSSLYRGTKFIIKKYASGNKDNIVRNNDRVYINVVVKNKEYRLATNASQAGVEKILSALEIPDVGNLSQVVVMKSKNDQGITNKCKMNLQDNNGNDIGFIGFHQFNNIAKLVASNWYNRQIERSSRTLGCSWEFIPVDDGWGERPL,positive +TACTGCATGCACACCACTTCAACTA,MTPDIQAPFLSLLLLFPVLTVANVPTLTTSDSINPRRTTPVSTTQSSPTSSPTKETSWSTTTTLLTASSPAPSPAASPGHDGASTPTSSPAPSPAASPGHDGASTPTSSPAPSPAASPGHDGASTPTSSPAPSPAASPGHDGASTPTSSPAPSPAASPGHNGTSSPTGSPAPSPAASPGHDGASTPTSSPAPSPAASPGHNGTSSPTGSPAPSPAASPGHDGASTPTSSPAPSPAASPGHNGTSSPTGSPAPSPTASPGHDSAPSLTSSPAPSPTASPGQHGASSPTSSDTSSMTTRSMSSSMVTSAHKGTSSRATMTPVSKGTPSSVPSSETAPTAASHITRTAASSPSIALSTSSNPKTSQQLSVRVSLYFLSFRITNLQFNSSLENPQTSYYQELQRSIWGLILQIYKQRDFLGLSEIKFRPGSVVVELTLAFREGTTAEWVKAQFSQLEAHAASYNLTISGVSVYSAPFPSSAQAGSGVPGWGIALLVLVCVLVALAIIYLIALVVCQCGRKKCEQLDVFPTLDAYHPMSEYSTYHTHGRYVPPGSTKRSPYEEVSAGNGGSNLSYTNLAATSANL,positive +TCCCACGCATTCTCCACATCAGTTGAATGGTGTGGTCACTTCCAGTCCCGCAGGGCACACCCTTTCTGTCCTTCCGTCAC,MSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA,positive +GGGAGAAUUCAACUGCCAUCUAGGCAGUAGGAAUACCCCCAUCCAAAGCUCGCUAGGCUGAACACAGUACUACAAGCUUCUGGACUCGGU,MNRPHSCLSFCWMYFAASGIRAVETANGKYAQKLFSDLFEDYSSALRPVEDTDAVLNVTLQVTLSQIKDMDERNQILTAYLWIRQTWHDAYLTWDRDQYDRLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDSPAITKSSCVVDVTYFPFDSQQCNLTFGSWTYNGNQVDIFNALDSGDLSDFIEDVEWEVHGMPAVKNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGEKVSLGVTILLAMTVFQLMVAEIMPASENVPLIGKYYIATMALITASTALTIMVMNIHFCGAEARPVPHWAKVVILKYMSRILFVYDVGESCLSPRHSQEPEQVTKVYSKLPESNLKTSRNKDLSRKKEVRKLLKNDLGYQGGIPQNTDSYCARYEALTKNIEYIAKCLKDHKATNSKGSEWKKVAKVIDRFFMWIFFAMVFVMTVLIIARAD,positive +GAAGTGAAAATGACAGAACACAACA,MTPDIQAPFLSLLLLFPVLTVANVPTLTTSDSINPRRTTPVSTTQSSPTSSPTKETSWSTTTTLLTASSPAPSPAASPGHDGASTPTSSPAPSPAASPGHDGASTPTSSPAPSPAASPGHDGASTPTSSPAPSPAASPGHDGASTPTSSPAPSPAASPGHNGTSSPTGSPAPSPAASPGHDGASTPTSSPAPSPAASPGHNGTSSPTGSPAPSPAASPGHDGASTPTSSPAPSPAASPGHNGTSSPTGSPAPSPTASPGHDSAPSLTSSPAPSPTASPGQHGASSPTSSDTSSMTTRSMSSSMVTSAHKGTSSRATMTPVSKGTPSSVPSSETAPTAASHITRTAASSPSIALSTSSNPKTSQQLSVRVSLYFLSFRITNLQFNSSLENPQTSYYQELQRSIWGLILQIYKQRDFLGLSEIKFRPGSVVVELTLAFREGTTAEWVKAQFSQLEAHAASYNLTISGVSVYSAPFPSSAQAGSGVPGWGIALLVLVCVLVALAIIYLIALVVCQCGRKKCEQLDVFPTLDAYHPMSEYSTYHTHGRYVPPGSTKRSPYEEVSAGNGGSNLSYTNLAATSANL,positive +GCCCACGGACGAATGCTTTGATGTTGTG,MVMGLGVLLLVFVLGLGLTPPTLAQDNSRYTHFLTQHYDAKPQGRDDRYCESIMRRRGLTSPCKDINTFIHGNKRSIKAICENKNGNPHRENLRISKSSFQVTTCKLHGGSPWPPCQYRATAGFRNVVVACENGLPVHLDQSIFRRP,positive +TCCCACGCATTCTCCACATCATAAGCTGAGCATCTTAGATCCCCGTCAAGGGCAGCGTAACCTTTCTGTCCTTCCGTCAC,MSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA,positive +GCGAAAACUCCGAUUUUCCUCUGUAGUGAUGGGAUUUUCCCGCCUGAACC,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,positive +AGGAUGGAUCGAGCGCUGGAGUCUGGAGAAUGUCAC,MDSTNYISKLFEYAQRQGQISDIKFEEVGTDGPDHLKTFTLRVVIKGHAYPNGVGKTKKEAKRNAAKHALIGMMETTEQKDASVSCPPSPAPSPAPPVRAVISQPKYVSWLNEHSQKNKLSLKALEGARVGPNNTSQCCRYVVGEKEYPEGFGNTKKEAKEEAAMQVYLELCGGSQTTGTVDENCNGTTGKHKEELNGKVVVLSEKVEHMNMSPAQNVPEQYSFITTEETNFIGILNHYCQKTKRFLDFKLVEKSGPSHNPQFVYKVLIDKREYPDGLGKTAKEAKQQAAQLAWSALQEQSDWNSQVSCRSTVSEEGGLSSLTPSSTWESQDATPSSLSIAGSTSESIIFSDSVNVSSPKDESPVNVKPKIRLAANFQMSPVKTKQEGPNLKGNDLGTLSSGRTSNQPVISRFSSEFDSIENIGKGGFGHVYKARRKLEQKYFAVKIVRSKGKAKREVGALADLQHPNIVRYYTAWLEDTAYRCDTASESDTTSDSGSSSSSEFLYIQMELCDKRTLKVWIDERNAHRKPKRREESLSITQQIVNGVEYIHSKKLLHRDLKPANIMFGMSDGEGKGEVKIGDFGLVTAEDNDNDENLLERTKKTGTVSYMAPEQRNQTSYDRKVDIFALGLIYFEPLWDLSGMEKAKVWNDVRSQRFPQQFNSQFTLENKVIESLLCANPEERPDARQLKTKLNECSRVLTRVHNIHQDNRTI,positive +GCGGAAGGUCCGAAGACCGGCGAAAGGAACGAGAUUGCC,IMEIRTVAVGIVAIKGVESEYYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHSGGEMFVALNQKGLPVKGKKTKKEQKTAHFLPMAIT,positive +GGGAAAAUAAUAAUAAA,GRQVDIDGEDYQRRDSIAQLLEDWGLIVIEDSAREDLFGLTNNFRVISFKQKDDWTLKAKYTIGN,positive +CTTCGGCTTCACAGCTTTGGAAAGGGTACAAATTAAACTA,RRIKRLEQEKLELSRKLQESTQTVQALQYSTVDGPLTASKDLEIKNLKEEIEKLRKQVTESSHLEQQLEEANAVRQELDDAFRQIKAYEKQIKTLQQEREDLNKELVQASERLKNQSKELKDAHCQRKLAMQEFMEINER,positive +AGCGACTGACGATCTTGAGTAAACCGCTCATCCACGTAGT,MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP,positive +GGGCGCUUAAUGUAUGCCGUAUGACCCUCAACAUCCGACUCAGUUAAGC,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,positive +ATACCAGTCTATTCAATTTGGCGGCGGGGGGGGAGCGGTTTCATCGTGAGATAGTATGTGCAATCA,MAINNTGSRRLLVTLTALFAALCGLYLLIGGGWLVAIGGSWYYPIAGLVMLGVAWMLWRSKRAALWLYAALLLGTMIWGVWEVGFDFWALTPRSDILVFFGIWLILPFVWRRLVIPASGAVAALVVALLISGGILTWAGFNDPQEINGTLSADATPAEAISPVADQDWPAYGRNQEGQRFSPLKQINADNVHNLKEAWVFRTGDVKQPNDPGEITNEVTPIKVGDTLYLCTAHQRLFALDAASGKEKWHYDPELKTNESFQHVTCRGVSYHEAKAETASPEVMADCPRRIILPVNDGRLIAINAENGKLCETFANKGVLNLQSNMPDTKPGLYEPTSPPIITDKTIVMAGSVTDNFSTRETSGVIRGFDVNTGELLWAFDPGAKDPNAIPSDEHTFTFNSPNSWAPAAYDAKLDLVYLPMGVTTPDIWGGNRTPEQERYASSILALNATTGKLAWSYQTVHHDLWDMDLPAQPTLADITVNGQKVPVIYAPAKTGNIFVLDRRNGELVVPAPEKPVPQGAAKGDYVTPTQPFSELSFRPTKDLSGADMWGATMFDQLVCRVMFHQMRYEGIFTPPSEQGTLVFPGNLGMFEWGGISVDPNREVAIANPMALPFVSKLIPRGPGNPMEQPKDAKGTGTESGIQPQYGVPYGVTLNPFLSPFGLPCKQPAWGYISALDLKTNEVVWKKRIGTPQDSMPFPMPVPVPFNMGMPMLGGPISTAGNVLFIAATADNYLRAYNMSNGEKLWQGRLPAGGQATPMTYEVNGKQYVVISAGGHGSFGTKMGDYIVAYALPDDVK,positive +GAACGACCACCGCTACCGACTACGCCATAAACTGCCCGG,MAIPKELLVLLLGIAILSKVAECAAFGSRRGLVETVFDVTRFGARPNTPADSTRGLMMAWRSACQSPGPAKVVIPPGTYTTGETIFQGPCTSPRPITIEIQGTLLSNTDMSLYTRAAWISIEHVDGIVITGGGTLNGQGKSSWQFADKSGSTPPLPSSLVFQTVRSSSIKNLNFVDAKGVHLKITDSSDISVSNIKITAPGDSPNTDGLHISDTINVNVTDSTIGTGDDCISIGDGNSNVYISNINCGPGHGISIGSLGKRLDETDVKGVTVRNCTFRGTTNGARIKTYMGSPSLQVSGVVYEDIILDNVKNPIVIDQHYHSKNRNEPSRVKLVDIHFRNIRGTTTSKIPVLLNCSEALPCEGVELVDIDLAPVGSIGPLLPATCQNAKTILNGKNNPPAC,positive +AGCTCAGAATGGATCCAAACGCTCATAACTCACTCCATACTCACTTGCTGATTCGCCAACAACACACCCTTAAACAGTCCCTTCGACATGAGAATTCGGCCGGATC,MAAGTAVGAWVLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISIIEPGEEGPTAGSVGGSGLGTLALALGILGGLGTAALLIGVILWQRRQRRGEERKAPENQEEEEERAELNQSEEPEAGESSTGGP,positive +GGACGCGUGGUACCAGGCCGAUCUAUGGACGCUAUAGGGACACCGGAUACUUUAACGAUUGGCUAAGCUUCCGCGGGGAUC,MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTSQVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHPTNVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEALGYRQDDPSYRSFHSAGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL,positive +CCGCCTCCTTCCGATTGAAAGGTCTGTTTTTGGGGTTGGTTTGGGTCAATAGGAGACGAGATAGGCGG,MGVHECPAWLWLLLSLLSLPLGLPVLGAPPRLICDSRVLERYLLEAKEAENITTGCAEHCSLNENITVPDTKVNFYAWKRMEVGQQAVEVWQGLALLSEAVLRGQALLVNSSQPWEPLQLHVDKAVSGLRSLTTLLRALGAQKEAISPPDAASAAPLRTITADTFRKLFRVYSNFLRGKLKLYTGEACRTGDR,positive +CTCCTCTGACTGTAACCACGCCGAAGAGCCTTTTTAGCGTACTGAAAAGGAGTTACTCTCGCATAGGTAGTCCAGAAGCC,MLDLFADAEPWQEPLAAGAVILRRFAFNAAEQLIRDINDVASQSPFRQMVTPGGYTMSVAMTNCGHLGWTTHRQGYLYSPIDPQTNKPWPAMPQSFHNLCQRAATAAGYPDFQPDACLINRYAPGAKLSLHQDKDEPDLRAPIVSVSLGLPAIFQFGGLKRNDPLKRLLLEHGDVVVWGGESRLFYHGIQPLKAGFHPLTIDCRYNLTFRQAGKKE,positive +GGCAGCGAAAGCAGAAGAAGUAUGUGACCAUGCUUCGGCAACUUCACAUGCGUAGCCAAACCGA,MTSHYVIAIFALMSSCLATAGPEPGALCELSPVSASHPVQALMESFTVLSGCASRGTTGLPQEVHVLNLRTAGQGPGQLQREVTLHLNPISSVHIHHKSVVFLLNSPHPLVWHLKTERLATGVSRLFLVSEGSVVQFSSANFSLTAETEERNFPHGNEHLLNWARKEYGAVTSFTELKIARNIYIKVGEDQVFPPKCNIGKNFLSLNYLAEYLQPKAAEGCVMSSQPQNEEVHIIELITPNSNPYSAFQVDITIDIRPSQEDLEVVKNLILILKCKKSVNWVIKSFDVKGSLKIIAPNSIGFGKESERSMTMTKSIRDDIPSTQGNLVKWALDNGYSPITSYTMAPVANRFHLRLENNAEEMGDEEVHTIPPELRILLDPGALPALQNPPIRGGEGQNGGLPFPFPDISRRVWNEEGEDGLPRPKDPVIPSIQLFPGLREPEEVQGSVDIALSVKCDNEKMIVAVEKDSFQASGYSGMDVTLLDPTCKAKMNGTHFVLESPLNGCGTRPRWSALDGVVYYNSIVIQVPALGDSSGWPDGYEDLESGDNGFPGDMDEGDASLFTRPEIVVFNCSLQQVRNPSSFQEQPHGNITFNMELYNTDLFLVPSQGVFSVPENGHVYVEVSVTKAEQELGFAIQTCFISPYSNPDRMSHYTIIENICPKDESVKFYSPKRVHFPIPQADMDKKRFSFVFKPVFNTSLLFLQCELTLCTKMEKHPQKLPKCVPPDEACTSLDASIIWAMMQNKKTFTKPLAVIHHEAESKEKGPSMKEPNPISPPIFHGLDTLTVMGIAFAAFVIGALLTGALWYIYSHTGETAGRQQVPTSPPASENSSAAHSIGSTQSTPCSSSSTA,positive +GGGAAUGGAUCCACAUCUACGAAUUCAGGGGACGUAGCAAUGACUGAGAUGCUGGGUUCACUGCAGACUUGACGAAGCUU,MKPGGNTIVIWMYAVATWLCFGSTSGWSFTLEDNNIFPKQYPIINFTTAGATVQSYTNFIRAVRGRLTTGADVRHEIPVLPNRVGLPINQRFILVELSNHAELSVTLALDVTNAYVVGYRAGNSAYFFHPDNQEDAEAITHLFTDVQNRYTFAFGGNYDRLEQLAGNLRENIELGNGPLEEAISALYYYSTGGTQLPTLARSFIICIQMISEAARFQYIEGEMRTRIRYNRRSAPDPSVITLENSWGRLSTAIQESNQGAFASPIQLQRRNGSKFSVYDVSILIPIIALMVYRCAPPPSSQFSLLIRPVVPNFNADVCMDPEPIVRIVGRNGLCVDVRDGRFHNGNAIQLWPCKSNTDANQLWTLKRDNTIRSNGKCLTTYGYSPGVYVMIYDCNTAATDATRWQIWDNGTIINPRSSLVLAATSGNSGTTLTVQTNIYAVSQGWLPTNNTQPFVTTIVGLYGLCLQANSGQVWIEDCSSEKAEQQWALYADGSIRPQQNRDNCLTSDSNIRETVVKILSCGPASSGQRWMFKNDGTILNLYSGLVLDVRASDPSLKQIILYPLHGDPNQIWLPLF,positive +AAGACGGCCGGGGAAACCCGAGAUCCGAGGUAACGC,MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC,positive +ACUCCUCCAAGCGACCAACAUCGGUCCCGUUUCAGAUCAA,MNIKAILSLCLFLILQCVRARVFVSRLEAASLLARSRRANSPFSMEETKQGSLERECREETCNFEEAREIFEDDQRTNAFWTLYIRPNPCLSNPCQNGGTCQHTHTVYMCVCPRGWEGRVCSQEVSTGQSCKVNNGRCDHYCEEEEAAAGGRRGAVCSCAPGYHLARNRRSCMAMEAFPCGRVASPKSDILMGNSSEAATDVPTPTSQAANVNSSSIIGDDSEPQASFGHSNHRGRVVGGKECPRGQCPWQVLISRKGAPVCGGTILSPQWILTAAHCTIYETKNLRILAGEHNVDEVEGSEQELGILRIVDHPSFNIKLSYDNDISLIQLSRPIQFTRYALPICLPNQRFVRGVLRSVVAGTVSGWGKLNEFGPAAGILQRLEVPYVDDEQCRAAMGSKVITANMFCAGYETGGQDSCSGDSGGPHATRYGSTWFLTGVVSWGKGCAREGKFGVYTKVLNYLDWIAQTMAETESHALPEPAQH,positive +CGTACCAAGATCCCACAACTAGCCGACCAGGATTGCCGGC,MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA,positive +GGGAGGACGAUGCGGACCGAAAAAGACCUGACUUCUAUACUAAGUCUACGUUCCCAGACGACUCGCCCGA,MHRPQRQQWIANGCAPKWRAMMRLAAAVAVLVVVTTLATAATAAGAKNEHQQQQQQQAWMESFPPMSADFPAGPALSDAEAAFLQVPEAERCRAHLKYLTSLPHVAGTPGDYETAEYVLNQFKSFGLDAVIQNETVLLTAPVEAASAKLYSADGTTLVYAAALSEDLLDPTADTPYRNHSFLGYSPTGSAAGPLVYVNYGSTEDFEYLVAQGVNLTGAIAIARYGSIFRGLKALNAQTHGMAGLIIYSDPSDDGYAQGQLYPNGPWRPESGIQRGSVVFNSLCGGDPGRGVDKCGIPLEDLIPSIPVLPMGYGDAVQFLSHIVGAPAPASWQGALPFQYNIGPGAFARIATNNTQYTTDIWNVVAYINGTDPVEGEDYVILGNHRDAWVYGAVDPNSGTAALLEIARAYGVLLQGGWQPKRGLVLTSWDGEEYGLLGSTAFGERFADDLILHAVAYLNIDTAVMGPQLWVTLVPSLLTHFRQTAALVKDPVTGNPLSVEWDGSYDIMGSGSDYTVFLDALGVASGDLLFGGAYGVYHSVFDSFNWMETQGDPTFQYHEACAQIFGLVGLRLADARILPFNYTEYAYAISTFYLPQVQQLATDAKLPVDFTALTNAAQQFASGASKIMSRVEQAYNNPNYNVVDLNSRLFLAERQFTDPNGIINRKWFKHTVFAPDRENGYDASSFPGIVDMIRTGNATLAQQAITSAATALSNVGTFLSY,positive +CTTTGGAGACAGTCCGTGGTAGGGCAGGTTGGGGTGACTTCGTGGAAGAAGCGAGACGGT,ASFTCLAIWALASAGVVPLVLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAAFFFVPVIISTVCYVSIIRCLSSSAVANRSKK,positive +AAAACCUACAACACACCCCUCAACUUUCCC,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,positive +ACAAAGCUGGAGUACUUACCGAACAUCCGUCUAACCCCU,MGVLLTQRTLLSLVLALLFPSMASMAAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQGLDVPKLREHCRERPGAFPSEETLRGLGRRGFLQTLNATLGCVLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILGLRNNIYCMAQLLDNSDTAEPTKAGRGASQPPTPTPASDAFQRKLEGCRFLHGYHRFMHSVGRVFSKWGESPNRSRRHSPHQALRKGVRRTRPSRKGKRLMTRGQLPR,positive +AGCUUACAAAACCUGUAGUUUUAUGCUUCACAUAUCGCACAGGACGCGUUAAGCU,PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGKISKIGPENPYNTPVFAIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDESFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPXRXKNPEMVIYQYMDDLYVGSDLEIGQHRAKIEELRSHLLSWGFTTPDKKHQKEPPFLWMGYELHPDSWTVQPIELPEKDSWTVNE,positive +AATACCCTCCCTTCGGTGCAAAGCACCGAAGGGAGGG,WPLTEEKIKALVEICXEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEEFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDXIIYQYMDDLYVGSDLEIGQHRTKVEELRQHLLXWGFTTPDKKHQKEPPFLWMGYELHP,positive +GGGAACUCGAUGAAGCGAAUUCUGUUGGCGAACUGUACGCAAGUACACUGGAUGACAGGCCUAUCUAUCGGAUCCACG,VFTDNSSPPAVPQSFQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGFGAYMSKAHGVDPNIRTGVRTITTGSPITYSTYGKFLADGGCSGGAYDIIICDECHSTDATSILGIGTVLDQAETAGARLVVLATATPPGSVTVSHPNIEEVALSTTGEIPFYGKAIPLEVIKGGRHLIFCHSKKKCDELAAKLVALGINAVAYYRGLDVSVIPTSGDVVVVSTDALMTGFTGDFDSVIDCNTCVTQTVDFSLDPTFTIETTTLPQDAVSRTQRRGRTGRGKPGIYRFVAPGERPSGMFDSSVLCECYDAGCAWYELTPAETTVRLRAYMNTPGLPVCQDHLEFWEGVFTGLTHIDAHFLSQTKQSGENFPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPTLHGPTPLLYRLGAVQNEVT,positive +ATCTTTGGCCCTCCACAATATCCCTCCATGGGGTACCAG,MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP,positive +CAACUACAUGUCGACCCUGAGAAGGCUGUGGAUGUGAUUAGGCCAGUUGC,MSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEMLDRHHTHFCPLEGESWQDFLRNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAFLCQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERETPTTDSMPPLLRQAIELFDHQGAEPAFLFGLELIICGLEKQLKCESGS,positive +AGCGACCU,PGGVQVSLLKEYYEDGYHIVRDIDSTVGVSISDASLPPRTWNGFLAPKTYKNVYIDTYHNQVFDDIFRTFTIDQHVKLACSLPHGRLRGADKPLIVKEWSGAMTDCAMYLNGRGIGSRFDGSFPSGKPSGACGARSKGSSSELSAQQKKDTLRYIEAQLDAFEVGAGWYFWTW,positive +CCACCACCACAACAAAACTCCAC,MKTLLLLLLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAKEPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHSRFQPSQSSTYSQPGQSFSIQYGTGSLSGIIGADQVSAFATQVEGLTVVGQQFGESVTEPGQTFVDAEFDGILGLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSHFSGSLNWVPVTKQAYWQIALDNIQVGGTVMFCSEGCQAIVDTGTSLITGPSDKIKQLQNAIGAAPVDGEYAVECANLNVMPDVTFTINGVPYTLSPTAYTLLDFVDGMQFCSSGFQGLDIHPPAGPLWILGDVFIRQFYSVFDRGNNRVGLAPAVP,positive +GUAUUCUCGGGUGGUUUAAUCAGGAGUAGAGGAGGGUGAUUCCUUUGGUUGGACUACGUGGAGCUUGUGUUG,MAGRSGDSDEELLKAVRLIKFLYQSNPPPNPEGTRQARRNRRRRWRERQRQIHSISERILSTYLGRSAEPVPLQLPPLERLTLDCNEDCGTSGTQGVGSPQILVESPTILESGAKE,positive +AGCGCGGGAUGUUAUGGCACGAUGUGUAGAGAAUAGCGCUGAUCGGGCAA,QELLCAASLISDRWVLTAAHCLLYPPWDKNFTVNDILVRIGKYARSRYERNMEKISTLEKIIIHPGYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDKQIVTSLLQAGHKGRVTGWGNLKEMWTVNMNEVQPSVLQMVNLPLVERPICKASTGIRVTDNMFCAGYKPEEGKRGDACEGDSGGPFVMKNPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIRKMVDRFG,negative +GUAUUCUCGGUGGUUUAAUCAGAGUAGAGGAGGCUGACUCCUUUGGUUGGUCUACGUGGAGGUUCUUUUG,MLNQLDNLTERVRGSNKLVDRWLHVRKHLLVAYYNLVGIKPGKESYMRLNEKALDDFCQSLVDYLSAGHFSIYERILHKLEGNGQLARAAKIWPQLEANTQQIMDYYDSSLETAIDHDNYLEFQQVLSDIGEALEARFVLEDKLILLVLDAARVKHPA,negative +UAUGAUGGUAGACGCCGUACCGCAUCAGGCCAAGUCGUCACAGAUCGUG,MSARGEEAAGEASGSQEQPEPALAEPKKRGPGRPRKPQQEPTGEPVPKRPRGRPKGSKNKGPSKAAQKKAETTGEKRPRGRPRKWPQQVVQEKPAQEEEEEEEEEEAEED,negative +GCCCUCCAACCACACCCCGCCAACAACCCC,QSVEESRGGLIKPTDTLTLTCTVSGFSLSSYGEVWDRQAPGNGLEYIGAIGNSGSTYYASWAKSRSTITRNTNLNTVTLKMTSLTAADTATYFCAR,negative +CUCUUUUUGUCCCCGCACGUUGAACUCCUGUCCCUCUACU,SNTRNFVLRDEDGNEHGVFTGKQPRQAALKAANRGSGTKANPDIIRLRERGTKKVHVFKAWKEIVDAPKNRPAWMPEKISKPFVKKERIEKLE,negative +UGACGCGAUCCGCCGUUCCCAUCCGCACGCCCUACACCU,MKKRKVLIPLMALSTILVSSTGNLEVIQAEVKQENRLLNESESSSQGLLGYYFSDLNFQAPMVVTSSTTGDLSIPSSELENIPSENQYFQSAIWSGFIKVKKSDEYTFATSADNHVTMWVDDQEVINKASNSNKIRLEKGRLYQIKIQYQRENPTEKGLDFKLYWTDSQNKKEVISSDNLQLPELKQKSSNSRKKRSTSAGPTVPDRDNDGIPDSLEVEGYTVDVKNKRTFLSPWISNIHEKKGLTKYKSSPEKWSTASDPYSDFEKVTGRIDKNVSPEARHPLVAAYPIVHVDMENIILSKNEDQSTQNTDSQTRTISKNTSTSRTHTSEVHGNAEVHASFFDIGGSVSAGFSNSNSSTVAIDHSLSLAGERTWAETMGLNTADTARLNANIRYVNTGTAPIYNVLPTTSLVLGKNQTLATIKAKENQLSQILAPNNYYPSKNLAPIALNAQDDFSSTPITMNYNQFLELEKTKQLRLDTDQVYGNIATYNFENGRVRVDTGSNWSEVLPQIQETTARIIFNGKDLNLVERRIAAVNPSDPLETTKPDMTLKEALKIAFGFNEPNGNLQYQGKDITEFDFNFDQQTSQNIKNQLAELNATNIYTVLDKIKLNAKMNILIRDKRFHYDRNNIAVGADESVVKEAHREVINSSTEGLLLNIDKDIRKILSGYIVEIEDTEGLKEVINDRYDMLNISSLRQDGKTFIDFKKYNDKLPLYISNPNYKVNVYAVTKENTIINPSENGDTSTNGIKKILIFSKKGYEIG,negative +TAGGGAATTCGTCGACGGATCCATCCTCAAAGGTTGGACACACATCAATAATAATTGTTCTTGTGGGCTCGCGCGGCGCATGCGTCGACCTGGAG,VENLMVQELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFSHFRLFDENNDAAILILLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVN,negative +GTCTCAATACGCACCCTGCATTCCCTTACTCGAGCCTAGC,MAGPQALAFGLLLAVVTATLAAAQRDCVCDNYKLATSCSLNEYGECQCTSYGTQNTVICSKLASKCLAMKAEMTHSKSGRRIKPEGAIQNNDGLYDPDCDEQGLFKAKQCNGTATCWCVNTAGVRRTDKDTEITCSERVRTYWIIIELKHKERESPYDHQSLQTALQEAFTSRYKLNQKFIKNIMYENNVITIDLMQNSSQKTQDDVDIADVAYYFEKDVKGESLFHSSKSMDLRVNGEPLDLDPGQTLIYYVDEKAPEFSMQGLTAGIIAVIVVVSLAVIAGIVVLVISTRKKSAKYEKAEIKEMGEIHRELNA,negative +GGCGGCCGTGAAATTTGCCAAATGCCGTCTTGGCTTTCGCCCAATGTATCCTGGGTGTTC,MSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEMLDRHHTHFCPLEGESWQDFLRNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAFLCQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERETPTTDSMPPLLRQAIELFDHQGAEPAFLFGLELIICGLEKQLKCESGS,negative +AAUAACUU,MKKRKVLIPLMALSTILVSSTGNLEVIQAEVKQENRLLNESESSSQGLLGYYFSDLNFQAPMVVTSSTTGDLSIPSSELENIPSENQYFQSAIWSGFIKVKKSDEYTFATSADNHVTMWVDDQEVINKASNSNKIRLEKGRLYQIKIQYQRENPTEKGLDFKLYWTDSQNKKEVISSDNLQLPELKQKSSNSRKKRSTSAGPTVPDRDNDGIPDSLEVEGYTVDVKNKRTFLSPWISNIHEKKGLTKYKSSPEKWSTASDPYSDFEKVTGRIDKNVSPEARHPLVAAYPIVHVDMENIILSKNEDQSTQNTDSQTRTISKNTSTSRTHTSEVHGNAEVHASFFDIGGSVSAGFSNSNSSTVAIDHSLSLAGERTWAETMGLNTADTARLNANIRYVNTGTAPIYNVLPTTSLVLGKNQTLATIKAKENQLSQILAPNNYYPSKNLAPIALNAQDDFSSTPITMNYNQFLELEKTKQLRLDTDQVYGNIATYNFENGRVRVDTGSNWSEVLPQIQETTARIIFNGKDLNLVERRIAAVNPSDPLETTKPDMTLKEALKIAFGFNEPNGNLQYQGKDITEFDFNFDQQTSQNIKNQLAELNATNIYTVLDKIKLNAKMNILIRDKRFHYDRNNIAVGADESVVKEAHREVINSSTEGLLLNIDKDIRKILSGYIVEIEDTEGLKEVINDRYDMLNISSLRQDGKTFIDFKKYNDKLPLYISNPNYKVNVYAVTKENTIINPSENGDTSTNGIKKILIFSKKGYEIG,negative +GCUAUCAUCAUUAACUUUAUUUAUUACCGUCAUUCAUUUCUGAAUGUCUGUUUACCCCUAUUUCAACCGGUUUUUUUU,PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGKISKIGPENPYNTPVFAIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDESFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPXRXKNPEMVIYQYMDDLYVGSDLEIGQHRAKIEELRSHLLSWGFTTPDKKHQKEPPFLWMGYELHPDSWTVQPIELPEKDSWTVNE,negative +CTTCTGCCCGCCTCCTTCCCTAGTCACTATTGTCTGGCGTGGGTAGGTGCCAATGGTAGGAGACGAGATAGGCGGACACT,MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC,negative +AGCGCGCACCTACTGTGATGTAGAAGTCACAGCAAGGCCC,MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQRGLKNVFDEAILAALEPPETQPKRKCCIF,negative +CGTTCGAAATTCGAACCTGTGTG,MAAKVASTSSEEAEGSLVTEGEMGEKALPVVYKRYICSFADCGAAYNKNWKLQAHLCKHTGEKPFPCKEEGCEKGFTSLHHLTRHSLTHTGEKNFTCDSDGCDLRFTTKANMKKHFNRFHNIKICVYVCHFENCGKAFKKHNQLKVHQFSHTQQLPYECPHEGCDKRFSLPSRLKRHEKVHAGYPCKKDDSCSFVGKTWTLYLKHVAECHQDLAVCDVCNRKFRHKDYLRDHQKTHEKERTVYLCPRDGCDRSYTTAFNLRSHIQSFHEEQRPFVCEHAGCGKCFAMKKSLERHSVVHDPEKRKLKEKCPRPKRSLASRLTGYIPPKSKEKNASVSGTEKTDSLVKNKPSGTETNGSLVLDKLTIQ,negative +GACCGGUGUGUCCUGAUCCAACUGCCACAAGUACCAUAUGCAGGUGACGU,MRKIVVAAIAVSLTTVSITASASADPSKDSKAQVSAAEAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKVKPSAASIDAAKKAGVNNGNPLDAVQQ,negative +CTTCTGCCCGCCTCCTTCCTTCTTGAATTTTGAGATGAGGTCACTAGGTCCTTCGCGGGGAGACGAGATAGGCGGACACT,MSPQRDRINAFYKDNPHPKGSRIVINREHLMIDRPYVLLAVLFVMFLSLIGLLAIAGIRLHRAAIYTAEIHKSLSTNLDVTNSIEHQVKDVLTPLFKIIGDEVGLRTPQRFTDLVKFISDKIKFLNPDREYDFRDLTWCINPPERIKLDYDQYCADVAAEELMNALVNSTLLEARATNQFLAVSKGNCSGPTTIRGQFSNMSLSLLDLYLSRGYNVSSIVTMTSQGMYGGTYLVEKPNLSSKGSELSQLSMHRVFEVGVIRNPGLGAPVFHMTNYFEQPVSNDFSNCMVALGELKFAALCHREDSITIPYQGSGKDVSFQLVKLGVWKSPTDMQSWVPLSTDDPVIDRLYLSSHRGVIADNQAKWAVPTTRTDDKLRMETCFQQACKGKIQALCENPDWAPLKDNRIPSYGVLSVNLSLTVELKIKIASGFGPLITHGSGMDLYKSNHNNMYWLTIPPMKNLALGVINTLEWIPRFRVSPNLFTVPIKEAGEDCHAPTYLPAEVDGDVKLSSNLVILPGQDLQYVLATYDTSRVEHAVVYYVYSPSRSFSYFYPFRLPIKGVPIELQVECFTWDQKLWCRHFCVLADSGSGGHITHSGMVGMGVSCTVTREDGTNRR,negative +TGTATCGTATTTGGTGATGTTTGGTGTTCA,XQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGSTGSPGPGYGYSNYGFPPYGGITFHPGVTKSNAGVTHGTINTKFKNGPKDCAKSDDEESLTLPEKETEGEGPSLPMACTKTEPIALASTMEDKEQDMGFQDNLFLEKALQLARRHANALFDYAVTGDVKMLLAVQRHLTAVQDENGDSVLHLAIIHLHAQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRVGADLSLLDRWGNSVLHLAAKEGHDRILSILLKSRKAAPLIDHPNGEGLNAIHIAVMSNSLPCLLLLVAAGAEVNAQEQKSGRTALHLAVEYDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWEKAGEDEGVVPGTTPLDMAANWQVFDILNGKPYEPVFTSDDILPQGDMKQLTEDTRLQLCKLLEIPDPDKNWATLAQKLGLGILNNAFRLSPAPSKTLMDNYEMNSGIVTASVTVVWRHPSANSALQSLLLETAHCYL,negative +TAGTGATGTTCGTGGCGAATGATACACTTA,MDSTNYISKLFEYAQRQGQISDIKFEEVGTDGPDHLKTFTLRVVIKGHAYPNGVGKTKKEAKRNAAKHALIGMMETTEQKDASVSCPPSPAPSPAPPVRAVISQPKYVSWLNEHSQKNKLSLKALEGARVGPNNTSQCCRYVVGEKEYPEGFGNTKKEAKEEAAMQVYLELCGGSQTTGTVDENCNGTTGKHKEELNGKVVVLSEKVEHMNMSPAQNVPEQYSFITTEETNFIGILNHYCQKTKRFLDFKLVEKSGPSHNPQFVYKVLIDKREYPDGLGKTAKEAKQQAAQLAWSALQEQSDWNSQVSCRSTVSEEGGLSSLTPSSTWESQDATPSSLSIAGSTSESIIFSDSVNVSSPKDESPVNVKPKIRLAANFQMSPVKTKQEGPNLKGNDLGTLSSGRTSNQPVISRFSSEFDSIENIGKGGFGHVYKARRKLEQKYFAVKIVRSKGKAKREVGALADLQHPNIVRYYTAWLEDTAYRCDTASESDTTSDSGSSSSSEFLYIQMELCDKRTLKVWIDERNAHRKPKRREESLSITQQIVNGVEYIHSKKLLHRDLKPANIMFGMSDGEGKGEVKIGDFGLVTAEDNDNDENLLERTKKTGTVSYMAPEQRNQTSYDRKVDIFALGLIYFEPLWDLSGMEKAKVWNDVRSQRFPQQFNSQFTLENKVIESLLCANPEERPDARQLKTKLNECSRVLTRVHNIHQDNRTI,negative +GCAGUUAACCAAGCCUGCAUACUGGAUAGACGGCUUAUUUGACUGAAUGCCUCCCGAAAGGUGCAGUU,MIPPPRRSASSTPKDYRSSRDLQPWRGVSSGDAAETSQQSRHRRDAIADGGGRLKGAAQSSPSSGTRRSGPYAQGRAMPKNENIPKPGKQRLGPRKKKLSTLKKKILLDRLERWRDKQHEGALSTPSATASSEEAKCNNPFPLCPPGELSPPPSPPATICPAVVDKSTSYGQVGGANGERSVWAITIYNLVDQEDVEDDDDHAEIERDLWDMSSAFGVVRSVQVPRGTAVQVSDAEVSAAAAAGEPAAVAAKVAFATNAEAECARDGLNGRIVGGKPLLVRIHRCDGHFCGGVCPGDPDGSGLWRVAIENLIDEEDDLDDEDEYAEISANVSAMMGCYGKLVDVQVRRSSPSKGEVQEDVATRAATTAGATQAVVVTFGSLAEAEACVQGIKGCRVGGKELDAHVVLDSERVLPSNPAFKCDQEHAHSSDVAAAVAGQGDSMMKQEAGTEPSPCVDQDTAAAVASSTEWRVVIRGLIDEDDLQDDDDDYAEVCSDVTALVSSYGAVVGLDIPRGRETGSCCYGAEPGEAVVVFRSLQEAEACARGLSGRKVAGNILDAQVLTQPAPSQQGPLQGGASGTGPPVANRERKPAKECPLPQHQASSHQSCGKVPELDGSGPGMLRGFGNRVEDCCGRPKIACTDSDEPQAIAAAAPPGQSIEGPKTTALAKAGKRIQTKYQEAAALPKPPGVRGGLPNAYVNQPPDKEVNDLVFEMLQLLFKFQERARLSDPSKAKTRRRLVIGLREVLRGVKAKKVRLLIVAPNVDAVGGEGGLDDKVVEIIDKAREAEYPVVFALSKRKIGKALGKTIKVSAVGVYSFDGANEQQKQLKRRMETISSLPSPSPRQSDPPTDDALASPPSSSACGDSQDPAGKGSRV,negative +GCAGAACCACCCCCUUCCAUCACUCCAGCC,IMEIRTVAVGIVAIKGVESEYYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHSGGEMFVALNQKGLPVKGKKTKKEQKTAHFLPMAIT,negative +CCCTTCATCATTAACCCGTCCACGCGC,MSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEMLDRHHTHFCPLEGESWQDFLRNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAFLCQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERETPTTDSMPPLLRQAIELFDHQGAEPAFLFGLELIICGLEKQLKCESGS,negative +UGACGCGAUCCGCCGUUCCCAUCCGCACGCCCUACACCU,PHITDVVLDKANKTPLRQLDPSRLPDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFAKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRQSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPINRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDTASEATRPATLNRFSALQQTLPAENTDNRRVVQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRTRTPATKRSFSKEVEERSRERPSQPEGLRKAASLTEDRGRDPVKREATLPPVSPPKAALSVDEVEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRLGIESTLERSTIAREHMGRLLHQLLCAGHLSTAQYYQGLYETLELAEDMEIDIPHVWLYLAELITPILQEDGVPMGELFREITKPLRPMGKATSLLLEILGLLCKSMGPKKVGMLWREAGLSWREFLAEGQDVGSFVAEKKVEYTLGEESEAPGQRTLAFEELRRQLEKLLKDGGSNQRVFDWIDANLNEQQIASNTLVRALMTTVCYSAIIFETPLRVDVQVLKVRARLLQKYLCDEQKELQALYALQALVVTLEQPANLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFNWLREAEDEESDHN,negative +AGGCAGAGAAAGGUCGAUACGGACGGAAUGUGAUGGCC,MKKRKVLIPLMALSTILVSSTGNLEVIQAEVKQENRLLNESESSSQGLLGYYFSDLNFQAPMVVTSSTTGDLSIPSSELENIPSENQYFQSAIWSGFIKVKKSDEYTFATSADNHVTMWVDDQEVINKASNSNKIRLEKGRLYQIKIQYQRENPTEKGLDFKLYWTDSQNKKEVISSDNLQLPELKQKSSNSRKKRSTSAGPTVPDRDNDGIPDSLEVEGYTVDVKNKRTFLSPWISNIHEKKGLTKYKSSPEKWSTASDPYSDFEKVTGRIDKNVSPEARHPLVAAYPIVHVDMENIILSKNEDQSTQNTDSQTRTISKNTSTSRTHTSEVHGNAEVHASFFDIGGSVSAGFSNSNSSTVAIDHSLSLAGERTWAETMGLNTADTARLNANIRYVNTGTAPIYNVLPTTSLVLGKNQTLATIKAKENQLSQILAPNNYYPSKNLAPIALNAQDDFSSTPITMNYNQFLELEKTKQLRLDTDQVYGNIATYNFENGRVRVDTGSNWSEVLPQIQETTARIIFNGKDLNLVERRIAAVNPSDPLETTKPDMTLKEALKIAFGFNEPNGNLQYQGKDITEFDFNFDQQTSQNIKNQLAELNATNIYTVLDKIKLNAKMNILIRDKRFHYDRNNIAVGADESVVKEAHREVINSSTEGLLLNIDKDIRKILSGYIVEIEDTEGLKEVINDRYDMLNISSLRQDGKTFIDFKKYNDKLPLYISNPNYKVNVYAVTKENTIINPSENGDTSTNGIKKILIFSKKGYEIG,negative +AGCGACCU,MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTSQVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHPTNVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEALGYRQDDPSYRSFHSAGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL,negative +AAGCCGGAUGCACGAAUAUUGAGGUAAGCG,MEKLLCFLVLTSLSHAFGQTDMSRKAFVFPKESDTSYVSLKAPLTKPLKAFTVCLHFYTELSSTRGYSIFSYATKRQDNEILIFWSKDIGYSFTVGGSEILFEVPEVTVAPVHICTSWESASGIVEFWVDGKPRVRKSLKKGYTVGAEASIILGQEQDSFGGNFEGSQSLVGDIGNVNMWDFVLSPDEINTIYLGGPFSPNVLNWRALKYEVQGEVFTKPQLWP,negative +CTACTGAATTTGGCTTTATAAGGGTTACGACCGTCCTCGT,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +AAAACUGAAGCCUCCGCGCUCACCGCGGCGGGCC,MAWYWWRRRRRRGWWKPRRRRWRRRRARRRGPARRHRARRRIVRHPCNGQTSSGNRVPRSVQAVDPKYVSLQLVWHSWDFRRGLFGQAGIKRMQQESDALTLSPVHRPKRPKRDTQVKEKTPEKDSDSAVQLRRLQPWIHSSQETKDEEEEIPEGPVQEQLLQQLQQQRLLRVQLESIAQEVLKIRRGHSLHPLLSSHA,negative +CTTCTGCCCGCCTCCTTCCGACGGTGATTGTTATCTCAGAGCCAGTTTGAACAACCCGGGAGACGAGATAGGCGGACACT,VENLMVQELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFSHFRLFDENNDAAILILLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVN,negative +AUGACGUACCCGCACAAGCCACCACAAGUCUUAAUCGCGCCACCCUUGC,MEGMLKGEGPGPLPPLLQQYVELRDQYPDYLLLFQVGDFYECFGEDAERLARALGLVLTHKTSKDFTTPMAGIPLRAFEAYAERLLKMGFRLAVADQVEPAEEAEGLVRREVTQLLTPGTLLQESLLPREANYLAAIATGDGWGLAFLDVSTGEFKGTVLKSKSALYDELFRHRPAEVLLAPELLENGAFLDEFRKRFPVMLSEAPFEPEGEGPLALRRARGALLAYAQRTQGGALSLQPFRFYDPGAFMRLPEATLRALEVFEPLRGQDTLFSVLDETRTAPGRRLLQSWLRHPLLDRGPLEARLDRVEGFVREGALREGVRRLLYRLADLERLATRLELGRASPKDLGALRRSLQILPELRALLGEEVGLPDLSPLKEELEAALVEDPPLKVSEGGLIREGYDPDLDALRAAHREGVAYFLELEERERERTGIPTLKVGYNAVFGYYLEVTRPYYERVPKEYRPVQTLKDRQRYTLPEMKEKEREVYRLEALIRRREEEVFLEVRERAKRQAEALREAARILAELDVYAALAEVAVRYGYVRPRFGDRLQIRAGRHPVVERRTEFVPNDLEMAHELVLITGPNMAGKSTFLRQTALIALLAQVGSFVPAEEAHLPLFDGIYTRIGASDDLAGGKSTFMVEMEEVALILKEATENSLVLLDEVGRGTSSLDGVAIATAVAEALHERRAYTLFATHYFELTALGLPRLKNLHVAAREEAGGLVFYHQVLPGPASKSYGVEVAAMAGLPKEVVARARALLQAMAARREGALDAVLERLLALDPDRLTPLEALRLLQELKALALGAPLDTMKG,negative +GGGAAUAAUAAUAAUAAUG,WPLTEEKIKALVEICXEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEEFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDXIIYQYMDDLYVGSDLEIGQHRTKVEELRQHLLXWGFTTPDKKHQKEPPFLWMGYELHP,negative +GGGACACAATGGACGUGCGCATAGGAAUUGCUCUCAAAAAACUGGACAAAAUAAUUUACGGCCGAACGCUUGCUCCGCCCUCUCUCAUAACGGCCGACAUGAGAG,MASNFTQFVLVDNGGTGDVTVAPSNFANGVAEWISSNSRSQAYKVTCSVRQSSAQNRKYTIKVEVPKVATQTVGGVELPVAAWRSYLNMELTIPIFATNSDCELIVKAMQGLLKDGNPIPSAIAANSGIY,negative +TATTAGCAACAATATTAGCAACAA,MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICEVEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASSIVYKKEGEQVEFSFPLAFTVEKLTGSGELWWQAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLPQALPQYAGSGNLTLALEAKTGKLHQEVNLVVMRATQLQKNLTCEVWGPTSPKLMLSLKLENKEAKVSKREKAVWVLNPEAGMWQCLLSDSGQVLLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQAERMSQIKRLLSEKKTCQCPHRFQKTCSPI,negative +AAAACCUACAACACACCCCUCAACUUUCCC,WPLTEEKIKALVEICXEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEEFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDXIIYQYMDDLYVGSDLEIGQHRTKVEELRQHLLXWGFTTPDKKHQKEPPFLWMGYELHP,negative +TAATACGACTCACTATAGGGAAGAGGTCAGATGGTCTAGCCGGAGGAGTCAGTAATCGGTAGACCTATGCGTGCTAGAGTGA,QDRPIKFSTEGATSQSYKQFIEALRERLRGGLIHDIPVLPDPTTLQERNRYITVELSNSDTESIEVGIDVTNAYVVAYRAGTQSYFLRDAPSSASDYLFTGTDQHSLPFYGTYGDLERWAHQSRQQIPLGLQALTHGISFFRSGGNDNEEKARTLIVIIQMVAEAARFRYISNRVRVSIQTGTAFQPDAAMISLENNWDNLSRGVQESVQDTFPNQVTLTNIRNEPVIVDSLSHPTVAVLALMLFVCNPPNANQSPLLIRSIVEKSKICSSRYEPTVRIGGRDGMCVDVYDNGYHNGNRIIMWKCKDRLEENQLWTLKSDKTIRSNGKCLTTYGYAPGSYVMIYDCTSAVAEATYWEIWDNGTIINPKSALVLSAESSSMGGTLTVQTNEYLMRQGWRTGNNTSPFVTSISGYSDLCMQAQGSNVWMADCDSNKKEQQWALYTDGSIRSVQNTNNCLTSKDHKQGSTILLMGCSNGWASQRWVFKNDGSIYSLYDDMVMDVKGSDPSLKQIILWPYTGKPNQIWLTLF,negative +CTCCTCTGACTGTAACCACGAGTTACTCTGCAAGAAGTTGTCAAGAGCGTGGGAGGGCGGGCATAGGTAGTCCAGAAGCC,DHNPPTIELIQRFCSDVDMWLKEDSSNVVAVHCKAGKGRTGTMICAYLVFSGIKKSADEALAWYDEKRTKDRKGVTIPSQRRYVQYFSKLVCSSVPYSKVSLNVCEIRFSESSCVQNLGMVECSISVLHDSATENAKPDRLKTLPIDFQKSFVLTIKPSIPVSGDVKFELTKKSPDKIICHFWLNTFFVRNYSPCESDGTVNKYIHTLSKSEIDDVHKDSEHKRFSEEFKISIVFEAENFSNDVQAEASEKERNENVLNFERSDYDSLSPNCYAEKKVLTAIVNDNTTKSQTIETLDHKDIVTKIQYDTSTNSKNTSTACKRKQPNSKTLLPSLNDSTKEEIKRNHIFNQPSIKKTDLIKWQNSEVHITRSINENKNINYNSYITCKQSSPKFNCGTEDGEEDWESGESTYL,negative +GGGAGAAGGGAAGTAACAGGCUAGAAGUUUAGACCAAGGGGCGGGAUGAGTGAGAAGAGGTGACGGTACCAG,MSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEMLDRHHTHFCPLEGESWQDFLRNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAFLCQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERETPTTDSMPPLLRQAIELFDHQGAEPAFLFGLELIICGLEKQLKCESGS,negative +CCAAGCAUCAGCUGG,VENLMVQELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFSHFRLFDENNDAAILILLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVN,negative +GGGAUCGUGGUAGUGCGAAGCCAGUAAACGAGGGCACCACGGUCC,MDSTNYISKLFEYAQRQGQISDIKFEEVGTDGPDHLKTFTLRVVIKGHAYPNGVGKTKKEAKRNAAKHALIGMMETTEQKDASVSCPPSPAPSPAPPVRAVISQPKYVSWLNEHSQKNKLSLKALEGARVGPNNTSQCCRYVVGEKEYPEGFGNTKKEAKEEAAMQVYLELCGGSQTTGTVDENCNGTTGKHKEELNGKVVVLSEKVEHMNMSPAQNVPEQYSFITTEETNFIGILNHYCQKTKRFLDFKLVEKSGPSHNPQFVYKVLIDKREYPDGLGKTAKEAKQQAAQLAWSALQEQSDWNSQVSCRSTVSEEGGLSSLTPSSTWESQDATPSSLSIAGSTSESIIFSDSVNVSSPKDESPVNVKPKIRLAANFQMSPVKTKQEGPNLKGNDLGTLSSGRTSNQPVISRFSSEFDSIENIGKGGFGHVYKARRKLEQKYFAVKIVRSKGKAKREVGALADLQHPNIVRYYTAWLEDTAYRCDTASESDTTSDSGSSSSSEFLYIQMELCDKRTLKVWIDERNAHRKPKRREESLSITQQIVNGVEYIHSKKLLHRDLKPANIMFGMSDGEGKGEVKIGDFGLVTAEDNDNDENLLERTKKTGTVSYMAPEQRNQTSYDRKVDIFALGLIYFEPLWDLSGMEKAKVWNDVRSQRFPQQFNSQFTLENKVIESLLCANPEERPDARQLKTKLNECSRVLTRVHNIHQDNRTI,negative +GACGGCAACCCGUUAUAACCUCCCACUGGCUAUCCCGUUAAGCUUCCCUA,QELLCAASLISDRWVLTAAHCLLYPPWDKNFTVNDILVRIGKYARSRYERNMEKISTLEKIIIHPGYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDKQIVTSLLQAGHKGRVTGWGNLKEMWTVNMNEVQPSVLQMVNLPLVERPICKASTGIRVTDNMFCAGYKPEEGKRGDACEGDSGGPFVMKNPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIRKMVDRFG,negative +CTTCTGCCCGCCTCCTTCCCTGGAGTGACGGGCTTATTTGAATCGGGCGAACTGGACTGGAGACGAGATAGGCGGACACT,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +ACACCCUCAACAAGUCCCGCCAACAACGC,MLDLFADAEPWQEPLAAGAVILRRFAFNAAEQLIRDINDVASQSPFRQMVTPGGYTMSVAMTNCGHLGWTTHRQGYLYSPIDPQTNKPWPAMPQSFHNLCQRAATAAGYPDFQPDACLINRYAPGAKLSLHQDKDEPDLRAPIVSVSLGLPAIFQFGGLKRNDPLKRLLLEHGDVVVWGGESRLFYHGIQPLKAGFHPLTIDCRYNLTFRQAGKKE,negative +UCCAAACCCCGUUGAGAGUUGAUCCGGUCUAGGGAAUGGAAAGAAGUAGGUAUCGAAGAGAAUGUACCCU,MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP,negative +AGGACUGAAAUAUUCACGUUGACGUUGUCUUGGAGUGCUGAUCGGAAAACCAAUAUGAUUAAGGGUCCUG,VVIRSNNFTDNAKTIIVQLNESIAINCTRPNNNTRKSIHIGPGRAFYTTGDIIGNIRQAHCNLSRTKWENTLKQIAKKLREQFGNKTIVFNH,negative +AAAGAGGAUUUGUGUUUUUCAGGAC,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,negative +CTTCTGCCCGCCTCCTTCCGGAATGATGCGTAAAGGACCGAGGGTGCTTGCCATAATCGGAGACGAGATAGGCGGACACT,MLNQLDNLTERVRGSNKLVDRWLHVRKHLLVAYYNLVGIKPGKESYMRLNEKALDDFCQSLVDYLSAGHFSIYERILHKLEGNGQLARAAKIWPQLEANTQQIMDYYDSSLETAIDHDNYLEFQQVLSDIGEALEARFVLEDKLILLVLDAARVKHPA,negative +CACGGUACCACCAAGUCACACGUUGAACUCCAUGCAGCUG,MGCRRTREGPSKAMIFPWKCQSTQRDLWNIFKLWGWTMLCCDFLAHHGTDCWTYHYSEKPMNWQRARRFCRDNYTDLVAIQNKAEIEYLEKTLPFSRSYYWIGIRKIGGIWTWVGTNKSLTEEAENWGDGEPNNKKNKEDCVEIYIKRNKDAGKWNDDACHKLKAALCYTASCQPWSCSGHGECVEIINNYTCNCDVGYYGPQCQFVIQCEPLEAPELGTMDCTHPLGNFSFSSQCAFSCSEGTNLTGIEETTCGPFGNWSSPEPTCQVIQCEPLSAPDLGIMNCSHPLASFSFTSACTFICSEGTELIGKKKTICESSGIWSNPSPICQKLDKSFSMIKEGDYNPLFIPVAVMVTAFSGLAFIIWLARRLKKGM,negative +AGUCAUUUAUAAGAUCCGACAACCUGUCUAUUAGUUGCGCCGAUUAAGUGACU,MASTSRLDALPRVTCPNHPDAILVEDYRAGDMICPECDRVIDVGSEWRTFSNDKATKDPSRVGDSQNPLLSDGDLSTMIGKGTGAASFDEFGNSKYQNRRTMSSSDRAMMNAFKEITTMADRINLPRNIVDRTNNLFKQVYEQKSLKGRANDAIASACLYIACRQEGVPRTFKEICAVSRISKKEIGRCFKLILKALETSVDLITTGDFMSRFCSNLCLPKQVQMAATHIA,negative +BAGCGCCGGTGGTGGTGGGGGTTGTTGTTACGCGGTATTAT,MEDDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKEEIAEVANEIESLGSTEERKNMQRNKQVAMGRKKFNMDPKKGIQFLIENGLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERDEFSIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNTGVFQSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIKNEPFKIPVWFFLQNLYESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEDWIKCIKAAISRDPFYEMLAARKKKVSSTKRH,negative +TCGGATGCGCCGAGTCTCCGTTTACCTTCGT,LQENFLPQPRQQHHGTLVLHYRPHREEAGMQHPCLWPGSSHCSDDSTLRRLQCESVTSIGAVCP,negative +CAUGUCUACAACAAUCUCGCCCGUUGAGUCUCGUCGAAUU,MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPGPHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR,negative +CACCTTGCGAAGCATAGTAACACCCAACACGCCCCATGCG,MSSTESPVPAAAAPAEAVPASTPAPAAEQPAVGNGEQRNNADAANNTSLYVGELDPSVTEAMLFEIFSMIGTVASIRVCRDAVTRRSLGYAYVNFLNAADGERAMEQLNYSLIRNRPCRIMWSQRDPALRRTGQGNIFIKNLDAGIDNKALHDTFAAFGNILSCKVATNETGSLGYGFVHYETAEAAEAAIKHVNGMLLNDKKVYVGHHIPRKERQAKIEETRANFTNVYAKNVDPEVTDDEFEKLFTKFGKITSCVLQRDEDGKSKGFGFVNFEDHNEAQKAVDELHDSDFKGQKLFVARAQKKSEREEELRRSYEAAKNEKLAKFQGVNLYLKNIPESYDDERLREEFAPFGAITSCKIMRAPSGVSRGFGFVCYSAPEEANKAVSEMNGKMLDNRPLYVALAQRKDVRRQQLEAQIMQRNQLRLQQQAAAQGMGYPGPGMYYPQPGAFPGQPGGMVPRPRYAPAGMMPQGMPMAPYGQPGQFPAGMMPQGYRPARPPRGAPNAAGGPAPPAGARPPTGVNGAPRPAGQPVPGQPMPRGPAARPAGRPEADQPGALTAAALAKASPEEQKQMLGEAIYPKVAASQPELAGKLTGMILELPVTELLHLLEESEALDAKVNEALEVLKEYQQNDSAGAEAEANAEAPKTEA,negative +GGGAGAAUUCCGACCAGAAGUUCGAUACGCCGUGGGGUGACGUUGGCUGCCCUUUCCUCUCUCCUCCUUCUUCU,MAWYWWRRRRRRGWWKPRRRRWRRRRARRRGPARRHRARRRIVRHPCNGQTSSGNRVPRSVQAVDPKYVSLQLVWHSWDFRRGLFGQAGIKRMQQESDALTLSPVHRPKRPKRDTQVKEKTPEKDSDSAVQLRRLQPWIHSSQETKDEEEEIPEGPVQEQLLQQLQQQRLLRVQLESIAQEVLKIRRGHSLHPLLSSHA,negative +GACAUCUGUAAGUAAGAUUCUAUCUGCAAAGCGGUUAGGGGGGCUCGGACUCUGAUUGCCUCCCCGCACC,IMEIRTVAVGIVAIKGVESEYYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHSGGEMFVALNQKGLPVKGKKTKKEQKTAHFLPMAIT,negative +CCCGUACCACCACACCCUAUGCACAUCGUUGUUUGUCGUCUUUCCCGCAU,MSSTESPVPAAAAPAEAVPASTPAPAAEQPAVGNGEQRNNADAANNTSLYVGELDPSVTEAMLFEIFSMIGTVASIRVCRDAVTRRSLGYAYVNFLNAADGERAMEQLNYSLIRNRPCRIMWSQRDPALRRTGQGNIFIKNLDAGIDNKALHDTFAAFGNILSCKVATNETGSLGYGFVHYETAEAAEAAIKHVNGMLLNDKKVYVGHHIPRKERQAKIEETRANFTNVYAKNVDPEVTDDEFEKLFTKFGKITSCVLQRDEDGKSKGFGFVNFEDHNEAQKAVDELHDSDFKGQKLFVARAQKKSEREEELRRSYEAAKNEKLAKFQGVNLYLKNIPESYDDERLREEFAPFGAITSCKIMRAPSGVSRGFGFVCYSAPEEANKAVSEMNGKMLDNRPLYVALAQRKDVRRQQLEAQIMQRNQLRLQQQAAAQGMGYPGPGMYYPQPGAFPGQPGGMVPRPRYAPAGMMPQGMPMAPYGQPGQFPAGMMPQGYRPARPPRGAPNAAGGPAPPAGARPPTGVNGAPRPAGQPVPGQPMPRGPAARPAGRPEADQPGALTAAALAKASPEEQKQMLGEAIYPKVAASQPELAGKLTGMILELPVTELLHLLEESEALDAKVNEALEVLKEYQQNDSAGAEAEANAEAPKTEA,negative +TAATACGACTCACTATAGGGAGACCCAAGCCGATTTATTTTGTGCAGCTTTTGTTCCCTTTAGTGAGGGTTAATT,MCLSEGIMCSIPPYLQFVFRYPLKSYSFGTKEPNYERDRSVPARFQRLQEDFEKYGMRRSVEGILLVHEHNLPHVLLLQLGTFFKLPGGELHPGEEEIEGLKRLLSEMLGRTDGIPVDWIPEDCIGNWWRPNFEPPRYPYIPAHVTKPKEQTRLFLIQLPEKTLFAVPSNYKLVAAPLFELFDNARAYGPIISSLPQVLSRFNFAYND,negative +TCCCACGCATTCTCCACATCGAGGAGTATCGGGGCACGATCCTATTTAAGGCCGATAACCCCTTTCTGTCCTTCCGTCAC,MKRASAGGSRLLAWVLWLQAWQVAAPCPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDNPWVCDCRARPLWAWLQKFRGSSSEVPCSLPQRLAGRDLKRLAANDLQGCAVATGPYHPIWTGRATDEEPLGLPKCCQPDAADKASVLEPGRPASAGNALKGRVPPGDSPPGNGSGPRHINDSPFGTLPGSAEPPLTAVRPEGSEPPGFPTSGPRRRPGCSRKNRTRSHCRLGQAGSGGGGTGDSEGSGALPSLTCSLTPLGLALVLWTVLGPC,negative +CAGCTCAGAAGCTTGATCCTGTGCGGGCGGCAAGGCCCTGACAGAGATACTGGCTCGGGACTCGAAGTCGTGCATCTGCA,MSMSPKHTTPFSVSDILSPLEESYKKVGMEGGGLGAPLAAYRQGQAAPPAAAMQQHAVGHHGAVTAAYHMTAAGVPQLSHSAVGGYCNGNLGNMSELPPYQDTMRNSASGPGWYGANPDPRFPAISRFMGPASGMNMSGMGGLGSLGDVSKNMAPLPSAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGGGGGGGAGCPQQQQAQQQSPRRVAVPVLVKDGKPCQAGAPAPGAGSLQGHAQQQAQQQAQAAQAAAAAISVGSGGPGLGAHPGHQPGSAGQSPDLAHHAASPAALQGQVSSLSHLNSSGSDYGTMSCSTLLYGRTW,negative +GGGAGGACGAUGCGGAUCAGCCAUGUUUACGUCACUCCUUGUCAAUCCUCAUCGGCAGACGACUCGCCCGA,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,negative +ATAACACGACATCCATATGTCAGTGGTCTGTGTACTTACACGGTATTCGA,MGVHECPAWLWLLLSLLSLPLGLPVLGAPPRLICDSRVLERYLLEAKEAENITTGCAEHCSLNENITVPDTKVNFYAWKRMEVGQQAVEVWQGLALLSEAVLRGQALLVNSSQPWEPLQLHVDKAVSGLRSLTTLLRALGAQKEAISPPDAASAAPLRTITADTFRKLFRVYSNFLRGKLKLYTGEACRTGDR,negative +UGAGCCGGUCGGCAGUAAUGUGACACUGCGG,MHGDTPTLHEYMLDLQPETTDLYCYEQLNDSSEEEDEIDGPAGQAEPDRAHYNIVTFCCKCDSTLRLCVQSTHVDIRTLEDLLMGTLGIVCPICSQKP,negative +UCCAGGGAUUGAAGUGUCGGGGUAGGAACAUAAAGGCGGC,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +ACACCCACCGCAGGCAGACGCAACGCCTCGGAGACTAGCC,PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGKISKIGPENPYNTPVFAIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDESFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPXRXKNPEMVIYQYMDDLYVGSDLEIGQHRAKIEELRSHLLSWGFTTPDKKHQKEPPFLWMGYELHPDSWTVQPIELPEKDSWTVNE,negative +CCACCACCACAACAAAACTCCAC,MDKLVVNYYEYKHPIINKDLAIGAHGGKKFPTLGAWYDVINEYEFQTRCPIILKNSHRNKHFTFACHLKNCPFKVLLSYAGNAASSETSSPSANNNTNPPGTPDHIHHHSNNMNNEDNDNNNGSNNKVSNDSKLDFVTDDLEYHLANTHPDDTNDKVESRSNEVNGNNDDDADANNIFKQQGVTIKNDTEDDSINKASIDRGLDDESGPTHGNDSGNHRHNEEDDVHTQMTKNYSDVVNDEDINVAIANAVANVDSQSNNKHDGKDDDATNNNDGQDNNTNNDHNNNSNINNNNVGSHGISSHSPSSIRDTSMNLDVFNSATDDIPGPFVVTKIEPYHSHPLEDNLSLGKFILTKIPKILQNDLKFDQILESSYNNSNHTVSKFKVSHYVEESGLLDILMQRYGLTAEDFEKRLLSQIARRITTYKARFVLKKKKMGEYNDLQPSSSSNNNNNNDGELSGTNLRSNSIDYAKHQEISSAGTSSNTTKNVNNNKNDSNDDNNGNNNNDASNLMESVLDKTSSHRYQPKKMPSVNKWSKPDQITHSDVSMVGLDESNDGGNENVHPTLAEVDAQEARETAQLAIDKINSYKRSIDDKNGDGHNNSSRNVVDENLINDMDSEDAHKSKRQHLSDITLEERNEDDKLPHEVAEQLRLLSSHLKEVENLHQNNDDDVDDVMVDVDVESQYNKNTTHHNNHHSQPHHDEEDVAGLIGKADDEEDLSDENIQPELRGQ,negative +GGGAGCTCAGAATAAACGCTCAAGGAGGTGGGTGGGATGTAGACTGGAGAGGGATTCGACATGAGGCCCGGATC,MSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEMLDRHHTHFCPLEGESWQDFLRNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAFLCQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERETPTTDSMPPLLRQAIELFDHQGAEPAFLFGLELIICGLEKQLKCESGS,negative +UCCCCCGCGCACAUUCCCGCCAACCUGCAA,MASTSRLDALPRVTCPNHPDAILVEDYRAGDMICPECDRVIDVGSEWRTFSNDKATKDPSRVGDSQNPLLSDGDLSTMIGKGTGAASFDEFGNSKYQNRRTMSSSDRAMMNAFKEITTMADRINLPRNIVDRTNNLFKQVYEQKSLKGRANDAIASACLYIACRQEGVPRTFKEICAVSRISKKEIGRCFKLILKALETSVDLITTGDFMSRFCSNLCLPKQVQMAATHIA,negative +CTCCTCTGACTGTAACCACGAGAAATTGGTACTGTATGAAACGGCAGCTGCACGTCGCGGCATAGGTAGTCCAGAAGCC,MAGPQALAFGLLLAVVTATLAAAQRDCVCDNYKLATSCSLNEYGECQCTSYGTQNTVICSKLASKCLAMKAEMTHSKSGRRIKPEGAIQNNDGLYDPDCDEQGLFKAKQCNGTATCWCVNTAGVRRTDKDTEITCSERVRTYWIIIELKHKERESPYDHQSLQTALQEAFTSRYKLNQKFIKNIMYENNVITIDLMQNSSQKTQDDVDIADVAYYFEKDVKGESLFHSSKSMDLRVNGEPLDLDPGQTLIYYVDEKAPEFSMQGLTAGIIAVIVVVSLAVIAGIVVLVISTRKKSAKYEKAEIKEMGEIHRELNA,negative +TGCAGTGCCGAAATAAAGTGTAAAAGCAGTATAAGAAGAC,MVDREQLVQKARLAEQAERYDDMAAAMKNVTELNEPLSNEERNLLSVAYKNVVGARRSSWRVISSIEQKTSADGNEKKIEMVRAYREKIEKELEAVCQDVLSLLDNYLIKNCSETQYESKVFYLKMKGDYYRYLAEVATGEKRATVVESSEKAYSEAHEISKEHMQPTHPIRLGLALNYSVFYYEIQNAPEQACHLAKTAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDQQDDDGGEGNN,negative +ATACCAGTCTATTCAATTTGGCGGCGGGGGGGGAGCGGTTTCATCGTGAGATAGTATGTGCAATCA,IMEIRTVAVGIVAIKGVESEYYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHSGGEMFVALNQKGLPVKGKKTKKEQKTAHFLPMAIT,negative +GGGUUACCUAGGUGUAGAUGCUCACUUACACAAACCUGUAGUUUUAUGCUUCACAUAUCGCACAGGACGCUUAAGUGACGUCUGAACUGCUUCGAA,MAKGEFIRTKPHVNVGTIGHVDHGKTTLTAALTYVAAAENPNVEVKDYGDIDKAPEERARGITINTAHVEYETAKRHYSHVDCPGHADYIKNMITGAAQMDGAILVVSAADGPMPQTREHILLARQVGVPYIVVFMNKVDMVDDPELLDLVEMEVRDLLNQYEFPGDEVPVIRGSALLALEEMHKNPKTKRGENEWVDKIWELLDAIDEYIPTPVRDVDKPFLMPVEDVFTITGRGTVATGRIERGKVKVGDEVEIVGLAPETRKTVVTGVEMHRKTLQEGIAGDNVGLLLRGVSREEVERGQVLAKPGSITPHTKFEASVYILKKEEGGRHTGFFTGYRPQFYFRTTDVTGVVRLPQGVEMVMPGDNVTFTVELIKPVALEEGLRFAIREGGRTVGAGVVTKILE,negative +AGCACUUCAGAUAUGAUAACAGGUUCAAGGAUGUGCACA,MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQRGLKNVFDEAILAALEPPETQPKRKCCIF,negative +AGTAATACGACTCACTATAGGGAGAATTCCGACCAGAAGGGUUAGCGGUCGUCUUAAGUAGUUUUUGGUCCTTTCCTCTCTCCTTCCTCTTCT,MSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA,negative +GGGCCAGGCAGCGAGAGAUAAGCAGAAGAAGUAUGUGACCAUGCUCCAGAGAGCAACUUCACAUGCGUAGCCAAACCGACCACACGCGUCCGAGA,MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYTFLLPEMDNCRSSSSPYVSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQDNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVLVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF,negative +CCACAGTACTACCGTATAACATGATGTCAA,MGCRRTREGPSKAMIFPWKCQSTQRDLWNIFKLWGWTMLCCDFLAHHGTDCWTYHYSEKPMNWQRARRFCRDNYTDLVAIQNKAEIEYLEKTLPFSRSYYWIGIRKIGGIWTWVGTNKSLTEEAENWGDGEPNNKKNKEDCVEIYIKRNKDAGKWNDDACHKLKAALCYTASCQPWSCSGHGECVEIINNYTCNCDVGYYGPQCQFVIQCEPLEAPELGTMDCTHPLGNFSFSSQCAFSCSEGTNLTGIEETTCGPFGNWSSPEPTCQVIQCEPLSAPDLGIMNCSHPLASFSFTSACTFICSEGTELIGKKKTICESSGIWSNPSPICQKLDKSFSMIKEGDYNPLFIPVAVMVTAFSGLAFIIWLARRLKKGM,negative +UCCCCCGCGCACAUUCCCGCCAACCUGCAA,MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC,negative +GATTGAAAGGTCTGTTTTTGGGGTTGGTTTGGGTCAATA,MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYTFLLPEMDNCRSSSSPYVSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQDNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVLVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF,negative +TATATATATATATAT,MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINYDEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQAVAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQGIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADMDFSALLSQISS,negative +CGTCTTGCATAATATAAAATTTTGTTTTGAGTTGTAATCGAATGCGGTCT,RRIKRLEQEKLELSRKLQESTQTVQALQYSTVDGPLTASKDLEIKNLKEEIEKLRKQVTESSHLEQQLEEANAVRQELDDAFRQIKAYEKQIKTLQQEREDLNKELVQASERLKNQSKELKDAHCQRKLAMQEFMEINER,negative +GCAAUGGUACGGUACUUCCAAGUGCGGGGGGGAGGUGGUGGUUCCAAAAGUGCACGCUACUUUGCUAA,MAITKINDCFELLSMVTYADKLKSLIKKEFSISFEEFAVLTYISENKEKEYYLKDIINHLNYKQPQVVKAVKILSQEDYFDKKRNEHDERTVLILVNAQQRKKIESLLSRVNKRITEANNEIEL,negative +UGCACGGAAAUGCAGAAGGCGUGGUCCGUGGGAGGCGACAAGCAUCAAUG,MPSNQEARLFLAVLVLAQVLPILVDSAAEKGFKQAFWQPLCQVSEELDDQPKGALFTLQAAASKIQKMRDAALRASIYAEINHGTNRAKAAVIVANHYAMKADSGLEALKQTLSSQEVTATATASYLKGRIDEYLNLLLQTKESGTSGCMMDTSGTNTVTKAGGTIGGVPCKLQLSPIQPKRPAATYLGKAGYVGLTRQADAANNFHDNDAECRLASGHNTNGLGKSGQLSAAVTMAAGYVTVANSQTAVTVQALDALQEASGAAHQPWIDAWKAKKALTGAETAEFRNETAGIAGKTGVTKLVEEALLKKKDSEASEIQTELKKYFSGHENEQWTAIEKLISEQPVAQNLVGDNQPTKLGELEGNAKLTTILAYYRMETAGKFEVLTQKHKPAESQQQAAETEGSCNKKDQNECKSPCKWHNDAENKKCTLDKEEAKKVADETAKDGKTGNTNTTGSSNSFVISKTPLWLAVLLF,negative +GCGAGCAUCAGCCGC,MSGGDGRGHNTGAHSTSGNINGGPTGLGVGGGASDGSGWSSENNPWGGGSGSGIHWGGGSGHGNGGGNGNSGGGSGTGGNLSAVAAPVAFGFPALSTPGAGGLAVSISAGALSAAIADIMAALKGPFKFGLWGVALYGVLPSQIAKDDPNMMSKIVTSLPADDITESPVSSLPLDKATVNVNVRVVDDVKDERQNISVVSGVPMSVPVVDAKPTERPGVFTASIPGAPVLNISVNNSTPAVQTLSPGVTNNTDKDVRPAGFTQGGNTRDAVIRFPKDSGHNAVYVSVSDVLSPDQVKQRQDEENRRQQEWDATHPVEAAERNYERARAELNQANEDVARNQERQAKAVQVYNSRKSELDAANKTLADAIAEIKQFNRFAHDPMAGGHRMWQMAGLKAQRAQTDVNNKQAAFDAAAKEKSDADAALSSAMESRKKKEDKKRSAENNLNDEKNKPRKGFKDYGHDYHPAPKTENIKGLGDLKPGIPKTPKQNGGGKRKRWTGDKGRKIYEWDSQHGELEGYRASDGQHLGSFDPKTGNQLKGPDPKRNIKKYL,negative +GAAGTAGCATGAACATATACCCGTTGACTCAATTTTATTTTAGTCCAACA,MNRPHSCLSFCWMYFAASGIRAVETANGKYAQKLFSDLFEDYSSALRPVEDTDAVLNVTLQVTLSQIKDMDERNQILTAYLWIRQTWHDAYLTWDRDQYDRLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDSPAITKSSCVVDVTYFPFDSQQCNLTFGSWTYNGNQVDIFNALDSGDLSDFIEDVEWEVHGMPAVKNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGEKVSLGVTILLAMTVFQLMVAEIMPASENVPLIGKYYIATMALITASTALTIMVMNIHFCGAEARPVPHWAKVVILKYMSRILFVYDVGESCLSPRHSQEPEQVTKVYSKLPESNLKTSRNKDLSRKKEVRKLLKNDLGYQGGIPQNTDSYCARYEALTKNIEYIAKCLKDHKATNSKGSEWKKVAKVIDRFFMWIFFAMVFVMTVLIIARAD,negative +TTTTTGCTGATCTCGGGTTTGGACTCCTGTTTATTTATAAGGAGACGAGAT,MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYTFLLPEMDNCRSSSSPYVSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQDNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVLVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF,negative +CAAUCCAUUCAUCUCUCGAAUGAGGAAGUAGCCCAAGAGGAGGAGGAGGAUGAGC,MAITKINDCFELLSMVTYADKLKSLIKKEFSISFEEFAVLTYISENKEKEYYLKDIINHLNYKQPQVVKAVKILSQEDYFDKKRNEHDERTVLILVNAQQRKKIESLLSRVNKRITEANNEIEL,negative +GGGAGCTCAGAATAAACGCTCAACATGGATGGGAGGGTGGGGCTGGGTTGTAGAATATTCGACATGAGGCCCGGATC,MEGMLKGEGPGPLPPLLQQYVELRDQYPDYLLLFQVGDFYECFGEDAERLARALGLVLTHKTSKDFTTPMAGIPLRAFEAYAERLLKMGFRLAVADQVEPAEEAEGLVRREVTQLLTPGTLLQESLLPREANYLAAIATGDGWGLAFLDVSTGEFKGTVLKSKSALYDELFRHRPAEVLLAPELLENGAFLDEFRKRFPVMLSEAPFEPEGEGPLALRRARGALLAYAQRTQGGALSLQPFRFYDPGAFMRLPEATLRALEVFEPLRGQDTLFSVLDETRTAPGRRLLQSWLRHPLLDRGPLEARLDRVEGFVREGALREGVRRLLYRLADLERLATRLELGRASPKDLGALRRSLQILPELRALLGEEVGLPDLSPLKEELEAALVEDPPLKVSEGGLIREGYDPDLDALRAAHREGVAYFLELEERERERTGIPTLKVGYNAVFGYYLEVTRPYYERVPKEYRPVQTLKDRQRYTLPEMKEKEREVYRLEALIRRREEEVFLEVRERAKRQAEALREAARILAELDVYAALAEVAVRYGYVRPRFGDRLQIRAGRHPVVERRTEFVPNDLEMAHELVLITGPNMAGKSTFLRQTALIALLAQVGSFVPAEEAHLPLFDGIYTRIGASDDLAGGKSTFMVEMEEVALILKEATENSLVLLDEVGRGTSSLDGVAIATAVAEALHERRAYTLFATHYFELTALGLPRLKNLHVAAREEAGGLVFYHQVLPGPASKSYGVEVAAMAGLPKEVVARARALLQAMAARREGALDAVLERLLALDPDRLTPLEALRLLQELKALALGAPLDTMKG,negative +AGUAAUACGACUCACUAUAGGGAGAAUUCCGACCAGAAGGGUUAGCGGUCGUCUUAAGUAGUUUUUGGUCCUUUCCUCUCUCCUUCCUCUUCU,MAGRSGDSDEELLKAVRLIKFLYQSNPPPNPEGTRQARRNRRRRWRERQRQIHSISERILSTYLGRSAEPVPLQLPPLERLTLDCNEDCGTSGTQGVGSPQILVESPTILESGAKE,negative +AAUAACUU,IMEIRTVAVGIVAIKGVESEYYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHSGGEMFVALNQKGLPVKGKKTKKEQKTAHFLPMAIT,negative +TCAAACGTTGGATTAAGGTCAAATGAGTCGTTTTTC,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +UGCACGGAAAUGCAGAAGGCGUGGUCCGUGGGAGGCGACAAGCAUCAAUG,MKPGGNTIVIWMYAVATWLCFGSTSGWSFTLEDNNIFPKQYPIINFTTAGATVQSYTNFIRAVRGRLTTGADVRHEIPVLPNRVGLPINQRFILVELSNHAELSVTLALDVTNAYVVGYRAGNSAYFFHPDNQEDAEAITHLFTDVQNRYTFAFGGNYDRLEQLAGNLRENIELGNGPLEEAISALYYYSTGGTQLPTLARSFIICIQMISEAARFQYIEGEMRTRIRYNRRSAPDPSVITLENSWGRLSTAIQESNQGAFASPIQLQRRNGSKFSVYDVSILIPIIALMVYRCAPPPSSQFSLLIRPVVPNFNADVCMDPEPIVRIVGRNGLCVDVRDGRFHNGNAIQLWPCKSNTDANQLWTLKRDNTIRSNGKCLTTYGYSPGVYVMIYDCNTAATDATRWQIWDNGTIINPRSSLVLAATSGNSGTTLTVQTNIYAVSQGWLPTNNTQPFVTTIVGLYGLCLQANSGQVWIEDCSSEKAEQQWALYADGSIRPQQNRDNCLTSDSNIRETVVKILSCGPASSGQRWMFKNDGTILNLYSGLVLDVRASDPSLKQIILYPLHGDPNQIWLPLF,negative +GGACCUUUGUACCCCAGAUGACGGCUCAUUUCGUGCUUGAUGGGUACAAAUGGCAG,MANLGYWLLALFVTMWTDVGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGTWGQPHGGGWGQPHGGSWGQPHGGSWGQPHGGGWGQGGGTHNQWNKPSKPKTNLKHVAGAAAAGAVVGGLGGYMLGSAMSRPMIHFGNDWEDRYYRENMYRYPNQVYYRPVDQYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCVTQYQKESQAYYDGRRSSSTVLFSSPPVILLISFLIFLIVG,negative +ACTCGAACATTTCCACTAACCAACCATACTAAAGCACCGC,MGVLLTQRTLLSLVLALLFPSMASMAAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQGLDVPKLREHCRERPGAFPSEETLRGLGRRGFLQTLNATLGCVLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILGLRNNIYCMAQLLDNSDTAEPTKAGRGASQPPTPTPASDAFQRKLEGCRFLHGYHRFMHSVGRVFSKWGESPNRSRRHSPHQALRKGVRRTRPSRKGKRLMTRGQLPR,negative +TATTAGTAATACTATTAGTAATAC,MASTSRLDALPRVTCPNHPDAILVEDYRAGDMICPECDRVIDVGSEWRTFSNDKATKDPSRVGDSQNPLLSDGDLSTMIGKGTGAASFDEFGNSKYQNRRTMSSSDRAMMNAFKEITTMADRINLPRNIVDRTNNLFKQVYEQKSLKGRANDAIASACLYIACRQEGVPRTFKEICAVSRISKKEIGRCFKLILKALETSVDLITTGDFMSRFCSNLCLPKQVQMAATHIA,negative +TAATACGACTCACTATAGGGAAGAGGTCAGATGGTCTAGCCGGAGGAGTCAGTAATCGGTAGACCTATGCGTGCTAGAGTGA,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +CCCUGAUGGUAGACGCCGGGGUGCCGGAA,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +ACAAGAAGGACAGCACGAAUAAAACCUGCGUAAAUCCGCCCCAUUUGUGUAAGGGUAGUGGG,MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQRGLKNVFDEAILAALEPPETQPKRKCCIF,negative +TCCCTACGGCGCTAACCAGTGCTAGCCACTGCGGGGTTCCCTTGTTGCCACCGTGCTACAAC,MAAKVASTSSEEAEGSLVTEGEMGEKALPVVYKRYICSFADCGAAYNKNWKLQAHLCKHTGEKPFPCKEEGCEKGFTSLHHLTRHSLTHTGEKNFTCDSDGCDLRFTTKANMKKHFNRFHNIKICVYVCHFENCGKAFKKHNQLKVHQFSHTQQLPYECPHEGCDKRFSLPSRLKRHEKVHAGYPCKKDDSCSFVGKTWTLYLKHVAECHQDLAVCDVCNRKFRHKDYLRDHQKTHEKERTVYLCPRDGCDRSYTTAFNLRSHIQSFHEEQRPFVCEHAGCGKCFAMKKSLERHSVVHDPEKRKLKEKCPRPKRSLASRLTGYIPPKSKEKNASVSGTEKTDSLVKNKPSGTETNGSLVLDKLTIQ,negative +AAAACCUACAACACACCCCUCAACUUUCCC,MLDLFADAEPWQEPLAAGAVILRRFAFNAAEQLIRDINDVASQSPFRQMVTPGGYTMSVAMTNCGHLGWTTHRQGYLYSPIDPQTNKPWPAMPQSFHNLCQRAATAAGYPDFQPDACLINRYAPGAKLSLHQDKDEPDLRAPIVSVSLGLPAIFQFGGLKRNDPLKRLLLEHGDVVVWGGESRLFYHGIQPLKAGFHPLTIDCRYNLTFRQAGKKE,negative +GGGAGCTCAGAATAAACGCTCAATCGGTGGGCGGGTGGGGTGGTTGCAGAATGAATTCGACATGAGGCCCGGATC,SRWDSTQQRAVLAAAVEIMVKFSSQPHLAQVVAEDLLSPSVMDVGDFKISITEGLPSGVPCTSQWNSIAHWLLTLCALSETTNLSPDIIQANSLFSFYG,negative +CUUGCCGUAGACCCAUUUUCCAAUCACAAGUCACGCGUCUCAAGCUGUUA,MQQGQMAYDRAITVFSPDGRLFQVEYAREAVKKGSTALGMKFANGVLLISDKKVRSRLIEQNSIEKIQLIDDYVAAVTSGLVADARVLVDFARISAQQEKVTYGSLVNIENLVKRVADQMQQYTQYGGVRPYGVSLIFAGIDQIGPRLFDCDPAGTINEYKATAIGSGKDAVVSFLEREYKENLPEKEAVTLGIKALKSSLEEGEELKAPEIASITVGNKYRIYDQEEVKKFL,negative +AGCATATAGTATAAAATTATCATATTGGTGTACGTGTACGGGGTACTTTT,MAIPKELLVLLLGIAILSKVAECAAFGSRRGLVETVFDVTRFGARPNTPADSTRGLMMAWRSACQSPGPAKVVIPPGTYTTGETIFQGPCTSPRPITIEIQGTLLSNTDMSLYTRAAWISIEHVDGIVITGGGTLNGQGKSSWQFADKSGSTPPLPSSLVFQTVRSSSIKNLNFVDAKGVHLKITDSSDISVSNIKITAPGDSPNTDGLHISDTINVNVTDSTIGTGDDCISIGDGNSNVYISNINCGPGHGISIGSLGKRLDETDVKGVTVRNCTFRGTTNGARIKTYMGSPSLQVSGVVYEDIILDNVKNPIVIDQHYHSKNRNEPSRVKLVDIHFRNIRGTTTSKIPVLLNCSEALPCEGVELVDIDLAPVGSIGPLLPATCQNAKTILNGKNNPPAC,negative +GACUAAACGCAUUGUGCCCC,MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH,negative +TTGCGCGTTAATTGGGGGGGTGGGTGGGTT,VENLMVQELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFSHFRLFDENNDAAILILLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVN,negative +GTGATCGTCCAGCGACCGAGCAGGAAACTTATGTAACGACCCGAAATTCCTGCTTAGACT,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +CGGAATTCCGAGCGTGGGCGTGAGCCCTAAACACAAGTCCGCAGGGGTGTGGTAATATTCGCAGTTGTGTGTACGCCCACGCTCGAG,MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINYDEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQAVAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQGIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADMDFSALLSQISS,negative +GGATGGGTGGGTGGGGAGGTTGTAGACTGTAT,MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYTFLLPEMDNCRSSSSPYVSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQDNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVLVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF,negative +TCCCTACGGCGCTAACCAGTGCTAGCCACTGCGGGGTTCCCTTGTTGCCACCGTGCTACAAC,ASFTCLAIWALASAGVVPLVLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAAFFFVPVIISTVCYVSIIRCLSSSAVANRSKK,negative +AAGACCACACACACAGAAACAGGGAACAGCGUUCAA,MVDREQLVQKARLAEQAERYDDMAAAMKNVTELNEPLSNEERNLLSVAYKNVVGARRSSWRVISSIEQKTSADGNEKKIEMVRAYREKIEKELEAVCQDVLSLLDNYLIKNCSETQYESKVFYLKMKGDYYRYLAEVATGEKRATVVESSEKAYSEAHEISKEHMQPTHPIRLGLALNYSVFYYEIQNAPEQACHLAKTAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDQQDDDGGEGNN,negative +GGAGUCUUAGGCAGCGCGUUUUCGAGCUACUCCA,MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP,negative +GGCAGCGAAAGCGGAACAAGUAUGUAACCAUGCCUCGGCAACUUUACAUGCGUAGCCAAACCCA,MGVHECPAWLWLLLSLLSLPLGLPVLGAPPRLICDSRVLERYLLEAKEAENITTGCAEHCSLNENITVPDTKVNFYAWKRMEVGQQAVEVWQGLALLSEAVLRGQALLVNSSQPWEPLQLHVDKAVSGLRSLTTLLRALGAQKEAISPPDAASAAPLRTITADTFRKLFRVYSNFLRGKLKLYTGEACRTGDR,negative +TATAACGCCCGTGTTGCTCGGTTAT,QELLCAASLISDRWVLTAAHCLLYPPWDKNFTVNDILVRIGKYARSRYERNMEKISTLEKIIIHPGYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDKQIVTSLLQAGHKGRVTGWGNLKEMWTVNMNEVQPSVLQMVNLPLVERPICKASTGIRVTDNMFCAGYKPEEGKRGDACEGDSGGPFVMKNPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIRKMVDRFG,negative +GGACCUUUGUACCCCAGAUGAUGCUUUAUCAGGCGGAUGGGUACAAAUGGCAG,MAVAQELYGFPASKLDSFVAQWLQPTREWKEEVLETVQTVEQFLRQENFREDRGPARDVRVLKVLKVGCFGNGTVLRSTTDVELVVFLSCFHSFQEEAKHHQAVLRLIQKRMYYCQELMDLGLSNLSVTNRVPSSLIFTIQTRETWETITVTVVPAYRALGPSCPSSEVYANLIKANGYPGNFSPSFSELQRNFVKHRPTKLKSLLRLVKHWYQQYVRDKCPRANLPPLYALELLTVYAWEAGTREDANFRLDEGLATVMELLQDHELLCIYWTKHYTLQHPVIEACVRRQLRGQRPIILDPADPTNNVAEGYRWDIVAQRANQCLKQDCCYDNRDSPVPSWRVKRAPDIQVTVQEWGHSDLTFWVNPYEPIKKLKEKIQLSQGYLGLQRLSFQEPGGERQLIRSHCTLAYYGIFCDTHICLLDTISPEIQVFVKNPDGRSHAYAIHPLDYVLNLKQQIEDRQGLRCQEQRLEFQGHILEDWFDFKSYGIQDSVTVILSKTTEGAAPFVPS,negative +GATACACGGGCGGAGGAGGTGGGGGGGGGTAGGTGGGTAT,MPFVNKQFNYKDPVNGVDIAYIKIPNVGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAGHRLYGIAINPNRVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNRKTYLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLKNFTGLFEFYKLLCVRGIITSKTKSLDKGYNKALNDLCIKVNNWDLFFSPSEDNFTNDLNKGEEITSDTNIEAAEENISLDLIQQYYLTFNFDNEPENISIENLSSDIIGQLELMPNIERFPNGKKYELDKYTMFHYLRAQEFEHGKSRIALTNSVNEALLNPSRVYTFFSSDYVKKVNKATEAAMFLGWVEQLVYDFTDETSEVSTTDKIADITIIIPYIGPALNIGNMLYKDDFVGALIFSGAVILLEFIPEIAIPVLGTFALVSYIANKVLTVQTIDNALSKRNEKWDEVYKYIVTNWLAKVNTQIDLIRKKMKEALENQAEATKAIINYQYNQYTEEEKNNINFNIDDLSSKLNESINKAMININKFLNQCSVSYLMNSMIPYGVKRLEDFDASLKDALLKYIYDNRGTLIGQVDRLKDKVNNTLSTDIPFQLSKYVDNQRLLSTFTEYIKNIINTSILNLRYESNHLIDLSRYASKINIGSKVNFDPIDKNQIQLFNLESSKIEVILKNAIVYNSMYENFSTSFWIRIPKYFNSISLNNEYTIINCMENNSGWKVSLNYGEIIWTLQDTQEIKQRVVFKYSQMINISDYINRWIFVTITNNRLNNSKIYINGRLIDQKPISNLGNIHASNNIMFKLDGCRDTHRYIWIKYFNLFDKELNEKEIKDLYDNQSNSGILKDFWGDYLQYDKPYYMLNLYDPNKYVDVNNVGIRGYMYLKGPRGSVMTTNIYLNSSLYRGTKFIIKKYASGNKDNIVRNNDRVYINVVVKNKEYRLATNASQAGVEKILSALEIPDVGNLSQVVVMKSKNDQGITNKCKMNLQDNNGNDIGFIGFHQFNNIAKLVASNWYNRQIERSSRTLGCSWEFIPVDDGWGERPL,negative +GGGAGGGAAUCAGUGAAUGCUUAUACAUCCCUCCUUGAGCAGUCGAUUAGUUUCGACAGGAGGCUCAC,GSNITRVESETKVVILDSFEPLRAETDDAELSVAAECLKKPPKYPPALPIWARPDYNPPLLDRWKAPDYVPPTVHGCALPPQA,negative +GAAGCUUUCACACAACAAGGCCCGGGACUGUAUUAGGGAAAUUAGAGUACAGACAGUCGCCGUGGGUCGAAUUCCGCUCA,QELLCAASLISDRWVLTAAHCLLYPPWDKNFTVNDILVRIGKYARSRYERNMEKISTLEKIIIHPGYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDKQIVTSLLQAGHKGRVTGWGNLKEMWTVNMNEVQPSVLQMVNLPLVERPICKASTGIRVTDNMFCAGYKPEEGKRGDACEGDSGGPFVMKNPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIRKMVDRFG,negative +ACAAAGCUGGAGUACUUACCGAACAUCCGUCUAACCCCU,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,negative +CAGGTCAGTTCAGCGGATCCTGTCGAAAAACACACACCCCGAGGCGAATTCAGTGCAACTGCAGC,MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQRGLKNVFDEAILAALEPPETQPKRKCCIF,negative +NGACUGAUUUUUCCUUGNCAGUGUAAUUUCCUGGCUGCCC,MAAKVASTSSEEAEGSLVTEGEMGEKALPVVYKRYICSFADCGAAYNKNWKLQAHLCKHTGEKPFPCKEEGCEKGFTSLHHLTRHSLTHTGEKNFTCDSDGCDLRFTTKANMKKHFNRFHNIKICVYVCHFENCGKAFKKHNQLKVHQFSHTQQLPYECPHEGCDKRFSLPSRLKRHEKVHAGYPCKKDDSCSFVGKTWTLYLKHVAECHQDLAVCDVCNRKFRHKDYLRDHQKTHEKERTVYLCPRDGCDRSYTTAFNLRSHIQSFHEEQRPFVCEHAGCGKCFAMKKSLERHSVVHDPEKRKLKEKCPRPKRSLASRLTGYIPPKSKEKNASVSGTEKTDSLVKNKPSGTETNGSLVLDKLTIQ,negative +GTAAATCGTCGACAGGAATTGGCGGGCCGG,MAIPKELLVLLLGIAILSKVAECAAFGSRRGLVETVFDVTRFGARPNTPADSTRGLMMAWRSACQSPGPAKVVIPPGTYTTGETIFQGPCTSPRPITIEIQGTLLSNTDMSLYTRAAWISIEHVDGIVITGGGTLNGQGKSSWQFADKSGSTPPLPSSLVFQTVRSSSIKNLNFVDAKGVHLKITDSSDISVSNIKITAPGDSPNTDGLHISDTINVNVTDSTIGTGDDCISIGDGNSNVYISNINCGPGHGISIGSLGKRLDETDVKGVTVRNCTFRGTTNGARIKTYMGSPSLQVSGVVYEDIILDNVKNPIVIDQHYHSKNRNEPSRVKLVDIHFRNIRGTTTSKIPVLLNCSEALPCEGVELVDIDLAPVGSIGPLLPATCQNAKTILNGKNNPPAC,negative +GCTGCAGTTGCACTGAATTCGCCTCTCGCCTCCGTACACTTAGTCGACAGGATCCGCTGAACTGACCTG,MIPPPRRSASSTPKDYRSSRDLQPWRGVSSGDAAETSQQSRHRRDAIADGGGRLKGAAQSSPSSGTRRSGPYAQGRAMPKNENIPKPGKQRLGPRKKKLSTLKKKILLDRLERWRDKQHEGALSTPSATASSEEAKCNNPFPLCPPGELSPPPSPPATICPAVVDKSTSYGQVGGANGERSVWAITIYNLVDQEDVEDDDDHAEIERDLWDMSSAFGVVRSVQVPRGTAVQVSDAEVSAAAAAGEPAAVAAKVAFATNAEAECARDGLNGRIVGGKPLLVRIHRCDGHFCGGVCPGDPDGSGLWRVAIENLIDEEDDLDDEDEYAEISANVSAMMGCYGKLVDVQVRRSSPSKGEVQEDVATRAATTAGATQAVVVTFGSLAEAEACVQGIKGCRVGGKELDAHVVLDSERVLPSNPAFKCDQEHAHSSDVAAAVAGQGDSMMKQEAGTEPSPCVDQDTAAAVASSTEWRVVIRGLIDEDDLQDDDDDYAEVCSDVTALVSSYGAVVGLDIPRGRETGSCCYGAEPGEAVVVFRSLQEAEACARGLSGRKVAGNILDAQVLTQPAPSQQGPLQGGASGTGPPVANRERKPAKECPLPQHQASSHQSCGKVPELDGSGPGMLRGFGNRVEDCCGRPKIACTDSDEPQAIAAAAPPGQSIEGPKTTALAKAGKRIQTKYQEAAALPKPPGVRGGLPNAYVNQPPDKEVNDLVFEMLQLLFKFQERARLSDPSKAKTRRRLVIGLREVLRGVKAKKVRLLIVAPNVDAVGGEGGLDDKVVEIIDKAREAEYPVVFALSKRKIGKALGKTIKVSAVGVYSFDGANEQQKQLKRRMETISSLPSPSPRQSDPPTDDALASPPSSSACGDSQDPAGKGSRV,negative +GGGAGCTCAGAATAAACGCTCAAGGTGGTGGGCGGGGTGTAGAATTGGAAGGGATTCGACATGAGGCCCGGATC,MEGMLKGEGPGPLPPLLQQYVELRDQYPDYLLLFQVGDFYECFGEDAERLARALGLVLTHKTSKDFTTPMAGIPLRAFEAYAERLLKMGFRLAVADQVEPAEEAEGLVRREVTQLLTPGTLLQESLLPREANYLAAIATGDGWGLAFLDVSTGEFKGTVLKSKSALYDELFRHRPAEVLLAPELLENGAFLDEFRKRFPVMLSEAPFEPEGEGPLALRRARGALLAYAQRTQGGALSLQPFRFYDPGAFMRLPEATLRALEVFEPLRGQDTLFSVLDETRTAPGRRLLQSWLRHPLLDRGPLEARLDRVEGFVREGALREGVRRLLYRLADLERLATRLELGRASPKDLGALRRSLQILPELRALLGEEVGLPDLSPLKEELEAALVEDPPLKVSEGGLIREGYDPDLDALRAAHREGVAYFLELEERERERTGIPTLKVGYNAVFGYYLEVTRPYYERVPKEYRPVQTLKDRQRYTLPEMKEKEREVYRLEALIRRREEEVFLEVRERAKRQAEALREAARILAELDVYAALAEVAVRYGYVRPRFGDRLQIRAGRHPVVERRTEFVPNDLEMAHELVLITGPNMAGKSTFLRQTALIALLAQVGSFVPAEEAHLPLFDGIYTRIGASDDLAGGKSTFMVEMEEVALILKEATENSLVLLDEVGRGTSSLDGVAIATAVAEALHERRAYTLFATHYFELTALGLPRLKNLHVAAREEAGGLVFYHQVLPGPASKSYGVEVAAMAGLPKEVVARARALLQAMAARREGALDAVLERLLALDPDRLTPLEALRLLQELKALALGAPLDTMKG,negative +ATACCAGTCTATTCAATTGGGCGGGGACTGTCGGGATGTGTGTGGGCCAGATAGTATGTGCAATCA,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +GGUAGAUACGAUGGACUACCGCCACCCCGGGUCCGGGUGACGUUAAUUGAGGGCCCAUGACGCGCAGCCA,MRKIVVAAIAVSLTTVSITASASADPSKDSKAQVSAAEAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKVKPSAASIDAAKKAGVNNGNPLDAVQQ,negative +ACTCCATTCGTCTCGCGAGCGCAGTGACTCTGGACATTAT,MLNQLDNLTERVRGSNKLVDRWLHVRKHLLVAYYNLVGIKPGKESYMRLNEKALDDFCQSLVDYLSAGHFSIYERILHKLEGNGQLARAAKIWPQLEANTQQIMDYYDSSLETAIDHDNYLEFQQVLSDIGEALEARFVLEDKLILLVLDAARVKHPA,negative +CTTTTATAGGATCGCACCTATGAATCTAATAGTCAAGTCC,MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINYDEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQAVAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQGIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADMDFSALLSQISS,negative +UAAACCUGCUGGCAGUGUGACCUAAGGACCAAGCCGUUCCUGAGGAACGUC,MTSHYVIAIFALMSSCLATAGPEPGALCELSPVSASHPVQALMESFTVLSGCASRGTTGLPQEVHVLNLRTAGQGPGQLQREVTLHLNPISSVHIHHKSVVFLLNSPHPLVWHLKTERLATGVSRLFLVSEGSVVQFSSANFSLTAETEERNFPHGNEHLLNWARKEYGAVTSFTELKIARNIYIKVGEDQVFPPKCNIGKNFLSLNYLAEYLQPKAAEGCVMSSQPQNEEVHIIELITPNSNPYSAFQVDITIDIRPSQEDLEVVKNLILILKCKKSVNWVIKSFDVKGSLKIIAPNSIGFGKESERSMTMTKSIRDDIPSTQGNLVKWALDNGYSPITSYTMAPVANRFHLRLENNAEEMGDEEVHTIPPELRILLDPGALPALQNPPIRGGEGQNGGLPFPFPDISRRVWNEEGEDGLPRPKDPVIPSIQLFPGLREPEEVQGSVDIALSVKCDNEKMIVAVEKDSFQASGYSGMDVTLLDPTCKAKMNGTHFVLESPLNGCGTRPRWSALDGVVYYNSIVIQVPALGDSSGWPDGYEDLESGDNGFPGDMDEGDASLFTRPEIVVFNCSLQQVRNPSSFQEQPHGNITFNMELYNTDLFLVPSQGVFSVPENGHVYVEVSVTKAEQELGFAIQTCFISPYSNPDRMSHYTIIENICPKDESVKFYSPKRVHFPIPQADMDKKRFSFVFKPVFNTSLLFLQCELTLCTKMEKHPQKLPKCVPPDEACTSLDASIIWAMMQNKKTFTKPLAVIHHEAESKEKGPSMKEPNPISPPIFHGLDTLTVMGIAFAAFVIGALLTGALWYIYSHTGETAGRQQVPTSPPASENSSAAHSIGSTQSTPCSSSSTA,negative +GGGAGAGCGGAAGCGUGCUGGGCCGGAGUUGAGGCGUAGAUGGUUCAGAUCCGAACGAUGAAGCAUAACCCAGAGGUCGAUGGAUCC,MGCRRTREGPSKAMIFPWKCQSTQRDLWNIFKLWGWTMLCCDFLAHHGTDCWTYHYSEKPMNWQRARRFCRDNYTDLVAIQNKAEIEYLEKTLPFSRSYYWIGIRKIGGIWTWVGTNKSLTEEAENWGDGEPNNKKNKEDCVEIYIKRNKDAGKWNDDACHKLKAALCYTASCQPWSCSGHGECVEIINNYTCNCDVGYYGPQCQFVIQCEPLEAPELGTMDCTHPLGNFSFSSQCAFSCSEGTNLTGIEETTCGPFGNWSSPEPTCQVIQCEPLSAPDLGIMNCSHPLASFSFTSACTFICSEGTELIGKKKTICESSGIWSNPSPICQKLDKSFSMIKEGDYNPLFIPVAVMVTAFSGLAFIIWLARRLKKGM,negative +CUUUCCUAGCGCACAUGCGACCUCUAUGCGUAAUACGAACGUUGACGGU,MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA,negative +CAGCGAAAGUUGCGUAUGGGUCACAUCGCAGGCACAUGUCAUCUGGGCG,MQLPLALCLVCLLVHTAFRVVEGQGWQAFKNDATEIIPELGEYPEPPPELENNKTMNRAENGGRPPHHPFETKDVSEYSCRELHFTRYVTDGPCRSAKPVTELVCSGQCGPARLLPNAIGRGKWWRPSGPDFRCIPDRYRAQRVQLLCPGGEAPRARKVRLVASCKCKRLTRFHNQSELKDFGTEAARPQKGRKPRPRARSAKANQAELENAY,negative +CTCCTCTGACTGTAACCACGCCCATATCGGTGAATGCACGAGCAACCCGATTGACACGGGGCATAGGTAGTCCAGAAGCC,PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGKISKIGPENPYNTPVFAIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDESFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPXRXKNPEMVIYQYMDDLYVGSDLEIGQHRAKIEELRSHLLSWGFTTPDKKHQKEPPFLWMGYELHPDSWTVQPIELPEKDSWTVNE,negative +GAAGTAGCATGAACATATACCCGTTGACTCAATTTTATTTTAGTCCAACA,MTRCTADNSLTNPAYRRRTMATGEMKEFLGIKGTEPTDFGINSDAQDLPSPSRQASTRRMSIGESIDGKINDWEEPRLDIEGFVVDYFTHRIRQNGMEWFGAPGLPCGVQPEHEMMRVMGTIFEKKHAENFETFCEQLLAVPRISFSLYQDVVRTVGNAQTDQCPMSYGRLIGLISFGGFVAAKMMESVELQGQVRNLFVYTSLFIKTRIRNNWKEHNRSWDDFMTLGKQMKEDYERAEAEKVGRRKQNRRWSMIGAGVTAGAIGIVGVVVCGRMMFSLK,negative +GAAGTGAAAATGACAGAACACAACA,MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINYDEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQAVAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQGIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADMDFSALLSQISS,negative +GGGCCAGGCAGCGAGAGAUAAGCAGAAGAAGUAUGUGACCAUGCUCCAGAGAGCAACUUCACAUGCGUAGCCAAACCGACCACACGCGUCCGAGA,PHITDVVLDKANKTPLRQLDPSRLPDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFAKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRQSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPINRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDTASEATRPATLNRFSALQQTLPAENTDNRRVVQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRTRTPATKRSFSKEVEERSRERPSQPEGLRKAASLTEDRGRDPVKREATLPPVSPPKAALSVDEVEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRLGIESTLERSTIAREHMGRLLHQLLCAGHLSTAQYYQGLYETLELAEDMEIDIPHVWLYLAELITPILQEDGVPMGELFREITKPLRPMGKATSLLLEILGLLCKSMGPKKVGMLWREAGLSWREFLAEGQDVGSFVAEKKVEYTLGEESEAPGQRTLAFEELRRQLEKLLKDGGSNQRVFDWIDANLNEQQIASNTLVRALMTTVCYSAIIFETPLRVDVQVLKVRARLLQKYLCDEQKELQALYALQALVVTLEQPANLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFNWLREAEDEESDHN,negative +ACAAGAAGGACAGCACGAAUAAAACCUGCGUAAAUCCGCCCCAUUUGUGUAAGGGUAGUGGG,PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGKISKIGPENPYNTPVFAIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDESFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPXRXKNPEMVIYQYMDDLYVGSDLEIGQHRAKIEELRSHLLSWGFTTPDKKHQKEPPFLWMGYELHPDSWTVQPIELPEKDSWTVNE,negative +AGCGCGCACCTACTGTGATGAAGAAGTCACAGCAAGGCCC,MSGGDGRGHNTGAHSTSGNINGGPTGLGVGGGASDGSGWSSENNPWGGGSGSGIHWGGGSGHGNGGGNGNSGGGSGTGGNLSAVAAPVAFGFPALSTPGAGGLAVSISAGALSAAIADIMAALKGPFKFGLWGVALYGVLPSQIAKDDPNMMSKIVTSLPADDITESPVSSLPLDKATVNVNVRVVDDVKDERQNISVVSGVPMSVPVVDAKPTERPGVFTASIPGAPVLNISVNNSTPAVQTLSPGVTNNTDKDVRPAGFTQGGNTRDAVIRFPKDSGHNAVYVSVSDVLSPDQVKQRQDEENRRQQEWDATHPVEAAERNYERARAELNQANEDVARNQERQAKAVQVYNSRKSELDAANKTLADAIAEIKQFNRFAHDPMAGGHRMWQMAGLKAQRAQTDVNNKQAAFDAAAKEKSDADAALSSAMESRKKKEDKKRSAENNLNDEKNKPRKGFKDYGHDYHPAPKTENIKGLGDLKPGIPKTPKQNGGGKRKRWTGDKGRKIYEWDSQHGELEGYRASDGQHLGSFDPKTGNQLKGPDPKRNIKKYL,negative +AGUCAUUUAUAAGAUCCGACAACCUGUCUAUUAGUUGCGCCGAUUAAGUGACU,MGCRRTREGPSKAMIFPWKCQSTQRDLWNIFKLWGWTMLCCDFLAHHGTDCWTYHYSEKPMNWQRARRFCRDNYTDLVAIQNKAEIEYLEKTLPFSRSYYWIGIRKIGGIWTWVGTNKSLTEEAENWGDGEPNNKKNKEDCVEIYIKRNKDAGKWNDDACHKLKAALCYTASCQPWSCSGHGECVEIINNYTCNCDVGYYGPQCQFVIQCEPLEAPELGTMDCTHPLGNFSFSSQCAFSCSEGTNLTGIEETTCGPFGNWSSPEPTCQVIQCEPLSAPDLGIMNCSHPLASFSFTSACTFICSEGTELIGKKKTICESSGIWSNPSPICQKLDKSFSMIKEGDYNPLFIPVAVMVTAFSGLAFIIWLARRLKKGM,negative +GGCGATAGTTTCTATAGCAAGGTACAGCATTCTCTCTCCCTATAGAACCAATCCAGTACTAGC,PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGKISKIGPENPYNTPVFAIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDESFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPXRXKNPEMVIYQYMDDLYVGSDLEIGQHRAKIEELRSHLLSWGFTTPDKKHQKEPPFLWMGYELHPDSWTVQPIELPEKDSWTVNE,negative +AAGACGGCCGGCGCCAUAGCCGAGAUCCGAGGUGUUGA,MASNFTQFVLVDNGGTGDVTVAPSNFANGVAEWISSNSRSQAYKVTCSVRQSSAQNRKYTIKVEVPKVATQTVGGVELPVAAWRSYLNMELTIPIFATNSDCELIVKAMQGLLKDGNPIPSAIAANSGIY,negative +ATTTGCAACACTTACCACTAAAAGGGCCGACGACCGATGATGTTAGGTCCAGTGCTTTCT,MNIKAILSLCLFLILQCVRARVFVSRLEAASLLARSRRANSPFSMEETKQGSLERECREETCNFEEAREIFEDDQRTNAFWTLYIRPNPCLSNPCQNGGTCQHTHTVYMCVCPRGWEGRVCSQEVSTGQSCKVNNGRCDHYCEEEEAAAGGRRGAVCSCAPGYHLARNRRSCMAMEAFPCGRVASPKSDILMGNSSEAATDVPTPTSQAANVNSSSIIGDDSEPQASFGHSNHRGRVVGGKECPRGQCPWQVLISRKGAPVCGGTILSPQWILTAAHCTIYETKNLRILAGEHNVDEVEGSEQELGILRIVDHPSFNIKLSYDNDISLIQLSRPIQFTRYALPICLPNQRFVRGVLRSVVAGTVSGWGKLNEFGPAAGILQRLEVPYVDDEQCRAAMGSKVITANMFCAGYETGGQDSCSGDSGGPHATRYGSTWFLTGVVSWGKGCAREGKFGVYTKVLNYLDWIAQTMAETESHALPEPAQH,negative +GAGCCAGUAAGUGACCCGUACUAAUACUGUUGAGUAGUAUGUAGAGGAGUGGUGAUCCUCCAAACUGCUG,MSSSQKKAGGKAGKPTKRSQNYAALRKAQLPKPPALKVPVVKPTNTILPQTGCVWQSLGTPLSLSSFNGLGARFLYSFLKDFVGPRILEEDLIYRMVFSITPSHAGTFCLTDDVTTEDGRAVAHGNPMQEFPHGAFHANEKFGFELVFTAPTHAGMQNQNFKHSYAVALCLDFDAQPEGSKNPSFRFNEVWVERKAFPRAGPLRSLITVGLFDEADDLDRH,negative +GGUAGAUACGAUGGAUCAGGGUACCCCCUGUGGCCCGUCAACACAGGGGAAGUGGCAUGACGCGCAGCCA,MSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEMLDRHHTHFCPLEGESWQDFLRNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAFLCQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERETPTTDSMPPLLRQAIELFDHQGAEPAFLFGLELIICGLEKQLKCESGS,negative +CAGCGGCCCAGACCAGGAGGGGUGAUGGUGGGCAAGUGGGUCGCUG,MDSTNYISKLFEYAQRQGQISDIKFEEVGTDGPDHLKTFTLRVVIKGHAYPNGVGKTKKEAKRNAAKHALIGMMETTEQKDASVSCPPSPAPSPAPPVRAVISQPKYVSWLNEHSQKNKLSLKALEGARVGPNNTSQCCRYVVGEKEYPEGFGNTKKEAKEEAAMQVYLELCGGSQTTGTVDENCNGTTGKHKEELNGKVVVLSEKVEHMNMSPAQNVPEQYSFITTEETNFIGILNHYCQKTKRFLDFKLVEKSGPSHNPQFVYKVLIDKREYPDGLGKTAKEAKQQAAQLAWSALQEQSDWNSQVSCRSTVSEEGGLSSLTPSSTWESQDATPSSLSIAGSTSESIIFSDSVNVSSPKDESPVNVKPKIRLAANFQMSPVKTKQEGPNLKGNDLGTLSSGRTSNQPVISRFSSEFDSIENIGKGGFGHVYKARRKLEQKYFAVKIVRSKGKAKREVGALADLQHPNIVRYYTAWLEDTAYRCDTASESDTTSDSGSSSSSEFLYIQMELCDKRTLKVWIDERNAHRKPKRREESLSITQQIVNGVEYIHSKKLLHRDLKPANIMFGMSDGEGKGEVKIGDFGLVTAEDNDNDENLLERTKKTGTVSYMAPEQRNQTSYDRKVDIFALGLIYFEPLWDLSGMEKAKVWNDVRSQRFPQQFNSQFTLENKVIESLLCANPEERPDARQLKTKLNECSRVLTRVHNIHQDNRTI,negative +UGUAGUUUCCCUGUAUGC,MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINYDEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQAVAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQGIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADMDFSALLSQISS,negative +GGGGGGAGCAATATCTGTGTGTCAAAACCTAACGATGACT,MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC,negative +UCCCUGGCCCAAGAUCCUAAUAAAGUUUUUUCGGACCGGAGCGAAACCACUAUCCUCUUAAGCAAUCUGU,MSAPASTTQATGSTTSTTTKTAGATPATASGLFTIPDGDFFSTARAVVASDAVATNEDLSEIEAVWKDMKVPTDTMAQAAWDLVRHCADVGSSAQTEMIDTGPYSNGISRARLAAAIKEVCTLRQFCMKYAPVVWNWMLTNNSPPANWQAQGFKPEHKFAAFDFFNGVTNPAAIMPKEGLIRPPSEAEMNAAQTAAFVKITKARAQSNDFASLDAAVTRGRITGTTTAEAVVTLPPP,negative +UAAGCUCUUUGGCUUAGCCCGACACGUUGAACUCCAGAGU,MDKLVVNYYEYKHPIINKDLAIGAHGGKKFPTLGAWYDVINEYEFQTRCPIILKNSHRNKHFTFACHLKNCPFKVLLSYAGNAASSETSSPSANNNTNPPGTPDHIHHHSNNMNNEDNDNNNGSNNKVSNDSKLDFVTDDLEYHLANTHPDDTNDKVESRSNEVNGNNDDDADANNIFKQQGVTIKNDTEDDSINKASIDRGLDDESGPTHGNDSGNHRHNEEDDVHTQMTKNYSDVVNDEDINVAIANAVANVDSQSNNKHDGKDDDATNNNDGQDNNTNNDHNNNSNINNNNVGSHGISSHSPSSIRDTSMNLDVFNSATDDIPGPFVVTKIEPYHSHPLEDNLSLGKFILTKIPKILQNDLKFDQILESSYNNSNHTVSKFKVSHYVEESGLLDILMQRYGLTAEDFEKRLLSQIARRITTYKARFVLKKKKMGEYNDLQPSSSSNNNNNNDGELSGTNLRSNSIDYAKHQEISSAGTSSNTTKNVNNNKNDSNDDNNGNNNNDASNLMESVLDKTSSHRYQPKKMPSVNKWSKPDQITHSDVSMVGLDESNDGGNENVHPTLAEVDAQEARETAQLAIDKINSYKRSIDDKNGDGHNNSSRNVVDENLINDMDSEDAHKSKRQHLSDITLEERNEDDKLPHEVAEQLRLLSSHLKEVENLHQNNDDDVDDVMVDVDVESQYNKNTTHHNNHHSQPHHDEEDVAGLIGKADDEEDLSDENIQPELRGQ,negative +GCGAGCAUCAGCCGC,MASTSRLDALPRVTCPNHPDAILVEDYRAGDMICPECDRVIDVGSEWRTFSNDKATKDPSRVGDSQNPLLSDGDLSTMIGKGTGAASFDEFGNSKYQNRRTMSSSDRAMMNAFKEITTMADRINLPRNIVDRTNNLFKQVYEQKSLKGRANDAIASACLYIACRQEGVPRTFKEICAVSRISKKEIGRCFKLILKALETSVDLITTGDFMSRFCSNLCLPKQVQMAATHIA,negative +GGTTGGTGTGGTTGG,MVKSHIGSWILVLFVAMWSDVGLCKKRPKPGGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGTHGQWNKPSKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGSDYEDRYYRENMHRYPNQVYYRPVDQYSNQNNFVHDCVNITVKEHTVTTTTKGENFTETDIKMMERVVEQMCITQYQRESQAYYQRGASVILFSSPPVILLISFLIFLIVG,negative +CGAUACAGCACUGAUUGCGGUCGAGGUAGCUUGAUGGGCC,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,negative +AGCCGUCGCUAGUUUGAUUCCGUGUGUUAGUGGUU,MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINYDEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQAVAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQGIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADMDFSALLSQISS,negative +GGACGCGUGGUACCAGGCCGAUCUAUGGACGCUAUAGGGACACCGGAUACUUUAACGAUUGGCUAAGCUUCCGCGGGGAUC,MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPGPHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR,negative +GGCGACCCCCGGGCTACCAGACAATGTACGCAGCAAGAGTGACGGTCGTACCTCGGAGTC,MDSTNYISKLFEYAQRQGQISDIKFEEVGTDGPDHLKTFTLRVVIKGHAYPNGVGKTKKEAKRNAAKHALIGMMETTEQKDASVSCPPSPAPSPAPPVRAVISQPKYVSWLNEHSQKNKLSLKALEGARVGPNNTSQCCRYVVGEKEYPEGFGNTKKEAKEEAAMQVYLELCGGSQTTGTVDENCNGTTGKHKEELNGKVVVLSEKVEHMNMSPAQNVPEQYSFITTEETNFIGILNHYCQKTKRFLDFKLVEKSGPSHNPQFVYKVLIDKREYPDGLGKTAKEAKQQAAQLAWSALQEQSDWNSQVSCRSTVSEEGGLSSLTPSSTWESQDATPSSLSIAGSTSESIIFSDSVNVSSPKDESPVNVKPKIRLAANFQMSPVKTKQEGPNLKGNDLGTLSSGRTSNQPVISRFSSEFDSIENIGKGGFGHVYKARRKLEQKYFAVKIVRSKGKAKREVGALADLQHPNIVRYYTAWLEDTAYRCDTASESDTTSDSGSSSSSEFLYIQMELCDKRTLKVWIDERNAHRKPKRREESLSITQQIVNGVEYIHSKKLLHRDLKPANIMFGMSDGEGKGEVKIGDFGLVTAEDNDNDENLLERTKKTGTVSYMAPEQRNQTSYDRKVDIFALGLIYFEPLWDLSGMEKAKVWNDVRSQRFPQQFNSQFTLENKVIESLLCANPEERPDARQLKTKLNECSRVLTRVHNIHQDNRTI,negative +GGGAGAGGAGAGAACGUUCUACAGCGCCGGUGGGUGGGCAUAGGGUGGAUGCGCUGUCGAUCGAUCGAUCGAUG,MEGMLKGEGPGPLPPLLQQYVELRDQYPDYLLLFQVGDFYECFGEDAERLARALGLVLTHKTSKDFTTPMAGIPLRAFEAYAERLLKMGFRLAVADQVEPAEEAEGLVRREVTQLLTPGTLLQESLLPREANYLAAIATGDGWGLAFLDVSTGEFKGTVLKSKSALYDELFRHRPAEVLLAPELLENGAFLDEFRKRFPVMLSEAPFEPEGEGPLALRRARGALLAYAQRTQGGALSLQPFRFYDPGAFMRLPEATLRALEVFEPLRGQDTLFSVLDETRTAPGRRLLQSWLRHPLLDRGPLEARLDRVEGFVREGALREGVRRLLYRLADLERLATRLELGRASPKDLGALRRSLQILPELRALLGEEVGLPDLSPLKEELEAALVEDPPLKVSEGGLIREGYDPDLDALRAAHREGVAYFLELEERERERTGIPTLKVGYNAVFGYYLEVTRPYYERVPKEYRPVQTLKDRQRYTLPEMKEKEREVYRLEALIRRREEEVFLEVRERAKRQAEALREAARILAELDVYAALAEVAVRYGYVRPRFGDRLQIRAGRHPVVERRTEFVPNDLEMAHELVLITGPNMAGKSTFLRQTALIALLAQVGSFVPAEEAHLPLFDGIYTRIGASDDLAGGKSTFMVEMEEVALILKEATENSLVLLDEVGRGTSSLDGVAIATAVAEALHERRAYTLFATHYFELTALGLPRLKNLHVAAREEAGGLVFYHQVLPGPASKSYGVEVAAMAGLPKEVVARARALLQAMAARREGALDAVLERLLALDPDRLTPLEALRLLQELKALALGAPLDTMKG,negative +GGTTGGTGTGGTTGG,MLNQLDNLTERVRGSNKLVDRWLHVRKHLLVAYYNLVGIKPGKESYMRLNEKALDDFCQSLVDYLSAGHFSIYERILHKLEGNGQLARAAKIWPQLEANTQQIMDYYDSSLETAIDHDNYLEFQQVLSDIGEALEARFVLEDKLILLVLDAARVKHPA,negative +AGCAGCACAGAGGTCAGATGAAGCGATTGTAATCAACGCCGTAAGACCTCGAGTCGATTTCCTATGCGTGCTACCGTGAA,MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYTFLLPEMDNCRSSSSPYVSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQDNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVLVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF,negative +GGGACACAAUGGACGCACCUCCGACGCACAGUCGCAGGCUCGAAAGAGACUAAAUGCUAACGGCCGACAUGAGAG,MKEFEVKVASTAFVLVLFSLTINQILASETSTKFRSPVPAPTVPDWNHLPNEGNEENVVSAPKQDGASGGQKPYWTKREKMMKRLHAEPAGNTVRFRCAVDGNPKPQVLWYKNDLIVQKNDRVGGYKYRNQVLILESVVLSDKGNYMCVARNEYGSINHTYQLDVQERSASKPILAEGLPQNKSAYIGDDVTFKCKVYSDAHPHIQWLKSINNHNNAAPNYTVLKAAGVNTTDLDMEVLILKNVSFEEAGEYTCLAGNSIGISHQSAWLSVLPVPPPTTDTITKGIPNETNIIIYVMCGVLVILFGLAVVLVLYYHCYNGKDPPMLVRIENPDNIPPMTKIEHPTMLFGNTQAWQRMCMPMQEPFEFNIQLDLQWELQREDITLVERLDEGFFGQVFKADLVTCNNTRKEKMVCAVKMLKGNRNEKDVLDLLTEMDQMKRVGKHKNIINLLGVCTQNGPLWLVIEYAAQGNLRDYLRRNRPQNTLCNLVLPSEGRNPDDELPVPHGDTLTQKDIVSFAFQVARGLEFLAQKKCIHRDLAARNVLVTEELVMKIADFGLARDIRSCDYYRKHTRGHLPYKWMALEAMSDNIFTHATDVWSFGVLLWEIFSLAGSPYPGIKTHELVKFLRSGERLDKPQYASQEMYRLMRDCWEEDPSKRPNFRTLVEDLDRMLAESSTEVYIDFAAGCEAEYSESSEDESESQNSDEEDDDSVFERMRQIDSLSNGNIPFNEEDSSNSDPYVAPLLQNEENVLQNEHARLRSEA,negative +AAUAACUC,MDSTNYISKLFEYAQRQGQISDIKFEEVGTDGPDHLKTFTLRVVIKGHAYPNGVGKTKKEAKRNAAKHALIGMMETTEQKDASVSCPPSPAPSPAPPVRAVISQPKYVSWLNEHSQKNKLSLKALEGARVGPNNTSQCCRYVVGEKEYPEGFGNTKKEAKEEAAMQVYLELCGGSQTTGTVDENCNGTTGKHKEELNGKVVVLSEKVEHMNMSPAQNVPEQYSFITTEETNFIGILNHYCQKTKRFLDFKLVEKSGPSHNPQFVYKVLIDKREYPDGLGKTAKEAKQQAAQLAWSALQEQSDWNSQVSCRSTVSEEGGLSSLTPSSTWESQDATPSSLSIAGSTSESIIFSDSVNVSSPKDESPVNVKPKIRLAANFQMSPVKTKQEGPNLKGNDLGTLSSGRTSNQPVISRFSSEFDSIENIGKGGFGHVYKARRKLEQKYFAVKIVRSKGKAKREVGALADLQHPNIVRYYTAWLEDTAYRCDTASESDTTSDSGSSSSSEFLYIQMELCDKRTLKVWIDERNAHRKPKRREESLSITQQIVNGVEYIHSKKLLHRDLKPANIMFGMSDGEGKGEVKIGDFGLVTAEDNDNDENLLERTKKTGTVSYMAPEQRNQTSYDRKVDIFALGLIYFEPLWDLSGMEKAKVWNDVRSQRFPQQFNSQFTLENKVIESLLCANPEERPDARQLKTKLNECSRVLTRVHNIHQDNRTI,negative +GGAGACCGTACCATCTGTTCGTGGAAGCGCTTTGCTCGTCCATTAGCCTTGTGCTCGTGC,MKPGGNTIVIWMYAVATWLCFGSTSGWSFTLEDNNIFPKQYPIINFTTAGATVQSYTNFIRAVRGRLTTGADVRHEIPVLPNRVGLPINQRFILVELSNHAELSVTLALDVTNAYVVGYRAGNSAYFFHPDNQEDAEAITHLFTDVQNRYTFAFGGNYDRLEQLAGNLRENIELGNGPLEEAISALYYYSTGGTQLPTLARSFIICIQMISEAARFQYIEGEMRTRIRYNRRSAPDPSVITLENSWGRLSTAIQESNQGAFASPIQLQRRNGSKFSVYDVSILIPIIALMVYRCAPPPSSQFSLLIRPVVPNFNADVCMDPEPIVRIVGRNGLCVDVRDGRFHNGNAIQLWPCKSNTDANQLWTLKRDNTIRSNGKCLTTYGYSPGVYVMIYDCNTAATDATRWQIWDNGTIINPRSSLVLAATSGNSGTTLTVQTNIYAVSQGWLPTNNTQPFVTTIVGLYGLCLQANSGQVWIEDCSSEKAEQQWALYADGSIRPQQNRDNCLTSDSNIRETVVKILSCGPASSGQRWMFKNDGTILNLYSGLVLDVRASDPSLKQIILYPLHGDPNQIWLPLF,negative +TGACTGCCGCACCGACCATTCACGGTATTGGCACGGCC,MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICEVEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASSIVYKKEGEQVEFSFPLAFTVEKLTGSGELWWQAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLPQALPQYAGSGNLTLALEAKTGKLHQEVNLVVMRATQLQKNLTCEVWGPTSPKLMLSLKLENKEAKVSKREKAVWVLNPEAGMWQCLLSDSGQVLLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQAERMSQIKRLLSEKKTCQCPHRFQKTCSPI,negative +GTCAAGNACGCGAACCCCGCATTCCCAAGAACGGCAACCCT,MAWYWWRRRRRRGWWKPRRRRWRRRRARRRGPARRHRARRRIVRHPCNGQTSSGNRVPRSVQAVDPKYVSLQLVWHSWDFRRGLFGQAGIKRMQQESDALTLSPVHRPKRPKRDTQVKEKTPEKDSDSAVQLRRLQPWIHSSQETKDEEEEIPEGPVQEQLLQQLQQQRLLRVQLESIAQEVLKIRRGHSLHPLLSSHA,negative +GGTTGGTGTGGTTGG,MSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEMLDRHHTHFCPLEGESWQDFLRNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAFLCQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERETPTTDSMPPLLRQAIELFDHQGAEPAFLFGLELIICGLEKQLKCESGS,negative +GGAATGAGTGCCCTGCAAGCGAGGGCTAGC,MAIPKELLVLLLGIAILSKVAECAAFGSRRGLVETVFDVTRFGARPNTPADSTRGLMMAWRSACQSPGPAKVVIPPGTYTTGETIFQGPCTSPRPITIEIQGTLLSNTDMSLYTRAAWISIEHVDGIVITGGGTLNGQGKSSWQFADKSGSTPPLPSSLVFQTVRSSSIKNLNFVDAKGVHLKITDSSDISVSNIKITAPGDSPNTDGLHISDTINVNVTDSTIGTGDDCISIGDGNSNVYISNINCGPGHGISIGSLGKRLDETDVKGVTVRNCTFRGTTNGARIKTYMGSPSLQVSGVVYEDIILDNVKNPIVIDQHYHSKNRNEPSRVKLVDIHFRNIRGTTTSKIPVLLNCSEALPCEGVELVDIDLAPVGSIGPLLPATCQNAKTILNGKNNPPAC,negative +CAACGTGTGATATGTGGGTATACGCTTGGGTGTTACGCTGAGCACAGAGGGTATTCGTGT,MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA,negative +CGCCAGUGUGAAAGAUCCGAAGUUUAUGCCGGCACGCGCUGGCG,MKKTLIALAIAASAASGMAHAWMTGDFNGSVDIGGSITADDYRQKWEWKVGTGLNGFGNVLNDLTNGGTKLTITVTGNKPILLGRTKEAFATPVTGGVDGIPHIAFTDYEGASVVLRNPDGETNKKGLAYFVLPMKNAEGTKVGSVKVNASYAGVLGRGGVTSADGELLSLFADGLSSIFYGGLPRGSELSAGSAAAARTKLFGSLSRNDILGQIQRVNANITSLVDVAGSYRENMEYTDGTVVSAAYALGIANGQTIEATFNQAVTTSTQWSAPLNVAITYY,negative +CAGGAUGAACAAGCAGGACGUGAAAUGAAC,MAWYWWRRRRRRGWWKPRRRRWRRRRARRRGPARRHRARRRIVRHPCNGQTSSGNRVPRSVQAVDPKYVSLQLVWHSWDFRRGLFGQAGIKRMQQESDALTLSPVHRPKRPKRDTQVKEKTPEKDSDSAVQLRRLQPWIHSSQETKDEEEEIPEGPVQEQLLQQLQQQRLLRVQLESIAQEVLKIRRGHSLHPLLSSHA,negative +AAGACGGCCGGCGCCAUAGCCGAGAUCCGAGGUGUUGA,ASFTCLAIWALASAGVVPLVLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAAFFFVPVIISTVCYVSIIRCLSSSAVANRSKK,negative +ACTACACGAGGACCTACGACTACTACATTATGCCAACCGGTCTTGCTTCGACACAGATACCTC,MAIPKELLVLLLGIAILSKVAECAAFGSRRGLVETVFDVTRFGARPNTPADSTRGLMMAWRSACQSPGPAKVVIPPGTYTTGETIFQGPCTSPRPITIEIQGTLLSNTDMSLYTRAAWISIEHVDGIVITGGGTLNGQGKSSWQFADKSGSTPPLPSSLVFQTVRSSSIKNLNFVDAKGVHLKITDSSDISVSNIKITAPGDSPNTDGLHISDTINVNVTDSTIGTGDDCISIGDGNSNVYISNINCGPGHGISIGSLGKRLDETDVKGVTVRNCTFRGTTNGARIKTYMGSPSLQVSGVVYEDIILDNVKNPIVIDQHYHSKNRNEPSRVKLVDIHFRNIRGTTTSKIPVLLNCSEALPCEGVELVDIDLAPVGSIGPLLPATCQNAKTILNGKNNPPAC,negative +TCCCTACGGCGCTAACTTCTGCAAGAGGCCGTCAACGGGCGAGTTAGCCACCGTGCTACAAC,MSWLLFLAHRVALAALPCRRGSRGFGMFYAVRRGRKTGVFLTWNECRAQVDRFPAARFKKFATEDEAWAFVRKSASPEVSEGHENQHGQESEAKASKRLREPLDGDGHESAEPYAKHMKPSVEPAPPVSRDTFSYMGDFVVVYTDGCCSSNGRRRPRAGIGVYWGPGHPLNVGIRLPGRQTNQRAEIHAACKAIEQAKTQNINKLVLYTDSMFTINGITNWVQGWKKNGWKTSAGKEVINKEDFVALERLTQGMDIQWMHVPGHSGFIGNEEADRLAREGAKQSED,negative +UGUAGUUUCCCUGUAUGC,MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP,negative +CTTCTGCCCGCCTCCTTCCCTGGAGTGACGGGCTTATTTGAATCGGGCGAACTGGACTGGAGACGAGATAGGCGGACACT,DHNPPTIELIQRFCSDVDMWLKEDSSNVVAVHCKAGKGRTGTMICAYLVFSGIKKSADEALAWYDEKRTKDRKGVTIPSQRRYVQYFSKLVCSSVPYSKVSLNVCEIRFSESSCVQNLGMVECSISVLHDSATENAKPDRLKTLPIDFQKSFVLTIKPSIPVSGDVKFELTKKSPDKIICHFWLNTFFVRNYSPCESDGTVNKYIHTLSKSEIDDVHKDSEHKRFSEEFKISIVFEAENFSNDVQAEASEKERNENVLNFERSDYDSLSPNCYAEKKVLTAIVNDNTTKSQTIETLDHKDIVTKIQYDTSTNSKNTSTACKRKQPNSKTLLPSLNDSTKEEIKRNHIFNQPSIKKTDLIKWQNSEVHITRSINENKNINYNSYITCKQSSPKFNCGTEDGEEDWESGESTYL,negative +ATTGACCGCTGTGTGACGCAACACTCAAT,MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICEVEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASSIVYKKEGEQVEFSFPLAFTVEKLTGSGELWWQAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLPQALPQYAGSGNLTLALEAKTGKLHQEVNLVVMRATQLQKNLTCEVWGPTSPKLMLSLKLENKEAKVSKREKAVWVLNPEAGMWQCLLSDSGQVLLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQAERMSQIKRLLSEKKTCQCPHRFQKTCSPI,negative +AAAGAGCUAAUGUAGGAUGCUGGGGUAGUCCAGCCCUAGAAUAAGCGCUAGUACUACAAGCUUCUGGAGCUCGGU,MAWYWWRRRRRRGWWKPRRRRWRRRRARRRGPARRHRARRRIVRHPCNGQTSSGNRVPRSVQAVDPKYVSLQLVWHSWDFRRGLFGQAGIKRMQQESDALTLSPVHRPKRPKRDTQVKEKTPEKDSDSAVQLRRLQPWIHSSQETKDEEEEIPEGPVQEQLLQQLQQQRLLRVQLESIAQEVLKIRRGHSLHPLLSSHA,negative +GCCCGAUCUACUGCAUUACCGAAACGAUUUCCCCACUGU,MSSSQKKAGGKAGKPTKRSQNYAALRKAQLPKPPALKVPVVKPTNTILPQTGCVWQSLGTPLSLSSFNGLGARFLYSFLKDFVGPRILEEDLIYRMVFSITPSHAGTFCLTDDVTTEDGRAVAHGNPMQEFPHGAFHANEKFGFELVFTAPTHAGMQNQNFKHSYAVALCLDFDAQPEGSKNPSFRFNEVWVERKAFPRAGPLRSLITVGLFDEADDLDRH,negative +CTTCTGCCCGCCTCCTTCCCGCACTTGCAAACCTTCATGGTCTCGTGCTTGAGTGGTTGGAGACGAGATAGGCGGACACT,MNRPHSCLSFCWMYFAASGIRAVETANGKYAQKLFSDLFEDYSSALRPVEDTDAVLNVTLQVTLSQIKDMDERNQILTAYLWIRQTWHDAYLTWDRDQYDRLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDSPAITKSSCVVDVTYFPFDSQQCNLTFGSWTYNGNQVDIFNALDSGDLSDFIEDVEWEVHGMPAVKNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGEKVSLGVTILLAMTVFQLMVAEIMPASENVPLIGKYYIATMALITASTALTIMVMNIHFCGAEARPVPHWAKVVILKYMSRILFVYDVGESCLSPRHSQEPEQVTKVYSKLPESNLKTSRNKDLSRKKEVRKLLKNDLGYQGGIPQNTDSYCARYEALTKNIEYIAKCLKDHKATNSKGSEWKKVAKVIDRFFMWIFFAMVFVMTVLIIARAD,negative +AGUUUCAUCGUCCGAGCAAGAUCCUAAUGGCGUCCGGCGCGUUUAUGACU,MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINYDEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQAVAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQGIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADMDFSALLSQISS,negative +TGCCTTGTTATTGTGGTGGGCGGGTGGGAC,MAAKVASTSSEEAEGSLVTEGEMGEKALPVVYKRYICSFADCGAAYNKNWKLQAHLCKHTGEKPFPCKEEGCEKGFTSLHHLTRHSLTHTGEKNFTCDSDGCDLRFTTKANMKKHFNRFHNIKICVYVCHFENCGKAFKKHNQLKVHQFSHTQQLPYECPHEGCDKRFSLPSRLKRHEKVHAGYPCKKDDSCSFVGKTWTLYLKHVAECHQDLAVCDVCNRKFRHKDYLRDHQKTHEKERTVYLCPRDGCDRSYTTAFNLRSHIQSFHEEQRPFVCEHAGCGKCFAMKKSLERHSVVHDPEKRKLKEKCPRPKRSLASRLTGYIPPKSKEKNASVSGTEKTDSLVKNKPSGTETNGSLVLDKLTIQ,negative +GGGAGAATTCCGACCAGAAGGCTTGCTGTTGTTTCCCTGTTGTTTTGTCTCTCAACTTTATTGTGGTAAAGATCACTGGGTTGATAAGGGCTAACTCTAATTTGACTACATGGTCGGACCAATCAGTTCTTATGGGAGATGCATATGTGCGTCTACATGGATCCTCA,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +AUUUCUCUGAGAUGUUCGCAAGCGGGCCAGUCCCCUGAGCCGAUAUUUCAUACCACAAGAAAUGUGGCGCUCCGCGGUUGGUGAGCAUGCUCGGUCCGUCCGAGAAGCCUUAAAACUGCGACGACACAUUCACCUUGAACCAAGGGUUCAAGGGUUACAGCCUGCGGCGGCAUCUCGGAGAUUCC,MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP,negative +ACACGACGGGAATACTGACTCTCCCCCATGT,MSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA,negative +AATAGGGGGGGTTCGGTGCAAAGCACCGAACCCCCCC,MEGMLKGEGPGPLPPLLQQYVELRDQYPDYLLLFQVGDFYECFGEDAERLARALGLVLTHKTSKDFTTPMAGIPLRAFEAYAERLLKMGFRLAVADQVEPAEEAEGLVRREVTQLLTPGTLLQESLLPREANYLAAIATGDGWGLAFLDVSTGEFKGTVLKSKSALYDELFRHRPAEVLLAPELLENGAFLDEFRKRFPVMLSEAPFEPEGEGPLALRRARGALLAYAQRTQGGALSLQPFRFYDPGAFMRLPEATLRALEVFEPLRGQDTLFSVLDETRTAPGRRLLQSWLRHPLLDRGPLEARLDRVEGFVREGALREGVRRLLYRLADLERLATRLELGRASPKDLGALRRSLQILPELRALLGEEVGLPDLSPLKEELEAALVEDPPLKVSEGGLIREGYDPDLDALRAAHREGVAYFLELEERERERTGIPTLKVGYNAVFGYYLEVTRPYYERVPKEYRPVQTLKDRQRYTLPEMKEKEREVYRLEALIRRREEEVFLEVRERAKRQAEALREAARILAELDVYAALAEVAVRYGYVRPRFGDRLQIRAGRHPVVERRTEFVPNDLEMAHELVLITGPNMAGKSTFLRQTALIALLAQVGSFVPAEEAHLPLFDGIYTRIGASDDLAGGKSTFMVEMEEVALILKEATENSLVLLDEVGRGTSSLDGVAIATAVAEALHERRAYTLFATHYFELTALGLPRLKNLHVAAREEAGGLVFYHQVLPGPASKSYGVEVAAMAGLPKEVVARARALLQAMAARREGALDAVLERLLALDPDRLTPLEALRLLQELKALALGAPLDTMKG,negative +GGTTGGTATGGTTGG,PHITDVVLDKANKTPLRQLDPSRLPDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFAKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRQSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPINRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDTASEATRPATLNRFSALQQTLPAENTDNRRVVQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRTRTPATKRSFSKEVEERSRERPSQPEGLRKAASLTEDRGRDPVKREATLPPVSPPKAALSVDEVEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRLGIESTLERSTIAREHMGRLLHQLLCAGHLSTAQYYQGLYETLELAEDMEIDIPHVWLYLAELITPILQEDGVPMGELFREITKPLRPMGKATSLLLEILGLLCKSMGPKKVGMLWREAGLSWREFLAEGQDVGSFVAEKKVEYTLGEESEAPGQRTLAFEELRRQLEKLLKDGGSNQRVFDWIDANLNEQQIASNTLVRALMTTVCYSAIIFETPLRVDVQVLKVRARLLQKYLCDEQKELQALYALQALVVTLEQPANLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFNWLREAEDEESDHN,negative +CAGGAGGCTACTGTCCCTGGGC,MRANDALQVLGLLFSLARGSEVGNSQAVCPGTLNGLSVTGDAENQYQTLYKLYERCEVVMGNLEIVLTGHNADLSFLQWIREVTGYVLVAMNEFSTLPLPNLRVVRGTQVYDGKFAIFVMLNYNTNSSHALRQLRLTQLTEILSGGVYIEKNDKLCHMDTIDWRDIVRDRDAEIVVKDNGRSCPPCHEVCKGRCWGPGSEDCQTLTKTICAPQCNGHCFGPNPNQCCHDECAGGCSGPQDTDCFACRHFNDSGACVPRCPQPLVYNKLTFQLEPNPHTKYQYGGVCVASCPHNFVVDQTSCVRACPPDKMEVDKNGLKMCEPCGGLCPKACEGTGSGSRFQTVDSSNIDGFVNCTKILGNLDFLITGLNGDPWHKIPALDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSNLTTIGGRSLYNRGFSLLIMKNLNVTSLGFRSLKEISAGRIYISANRQLCYHHSLNWTKVLRGPTEERLDIKHNRPRRDCVAEGKVCDPLCSSGGCWGPGPGQCLSCRNYSRGGVCVTHCNFLNGEPREFAHEAECFSCHPECQPMEGTATCNGSGSDTCAQCAHFRDGPHCVSSCPHGVLGAKGPIYKYPDVQNECRPCHENCTQGCKGPELQDCLGQTLVLIGKTHLTMALTVIAGLVVIFMMLGGTFLYWRGRRIQNKRAMRRYLERGESIEPLDPSEKANKVLARIFKETELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANEFTRMARDPPRYLVIKRESGPGIAPGPEPHGLTNKKLEEVELEPELDLDLDLEAEEDNLATTTLGSALSLPVGTLNRPRGSQSLLSPSSGYMPMNQGNLGESCQESAVSGSSERCPRPVSLHPMPRGCLASESSEGHVTGSEAELQEKVSMCRSRSRSRSPRPRGDSAYHSQRHSLLTPVTPLSPPGLEEEDVNGYVMPDTHLKGTPSSREGTLSSVGLSSVLGTEEEDEDEEYEYMNRRRRHSPPHPPRPSSLEELGYEYMDVGSDLSASLGSTQSCPLHPVPIMPTAGTTPDEDYEYMNRQRDGGGPGGDYAAMGACPASEQGYEEMRAFQGPGHQAPHVHYARLKTLRSLEATDSAFDNPDYWHSRLFPKANAQRT,negative +CCGCGCAAGGGGUAACCGGAGAAUAUUUGG,MGVLLTQRTLLSLVLALLFPSMASMAAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQGLDVPKLREHCRERPGAFPSEETLRGLGRRGFLQTLNATLGCVLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILGLRNNIYCMAQLLDNSDTAEPTKAGRGASQPPTPTPASDAFQRKLEGCRFLHGYHRFMHSVGRVFSKWGESPNRSRRHSPHQALRKGVRRTRPSRKGKRLMTRGQLPR,negative +AAGACGGCCCGGUAUGUAGCCGGAGAUCCGAGACUUGCU,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,negative +GGGUUAACAAGAUACCGAGAGAGCUGCAGCAUAAGCCUGCAGAGUGGACCAGUACUACAAGCUUCUGGACUCGGU,MSARGEEAAGEASGSQEQPEPALAEPKKRGPGRPRKPQQEPTGEPVPKRPRGRPKGSKNKGPSKAAQKKAETTGEKRPRGRPRKWPQQVVQEKPAQEEEEEEEEEEAEED,negative +TCTGCTACGCTGAGTGGCTGTTTACCTTCGT,MKPGGNTIVIWMYAVATWLCFGSTSGWSFTLEDNNIFPKQYPIINFTTAGATVQSYTNFIRAVRGRLTTGADVRHEIPVLPNRVGLPINQRFILVELSNHAELSVTLALDVTNAYVVGYRAGNSAYFFHPDNQEDAEAITHLFTDVQNRYTFAFGGNYDRLEQLAGNLRENIELGNGPLEEAISALYYYSTGGTQLPTLARSFIICIQMISEAARFQYIEGEMRTRIRYNRRSAPDPSVITLENSWGRLSTAIQESNQGAFASPIQLQRRNGSKFSVYDVSILIPIIALMVYRCAPPPSSQFSLLIRPVVPNFNADVCMDPEPIVRIVGRNGLCVDVRDGRFHNGNAIQLWPCKSNTDANQLWTLKRDNTIRSNGKCLTTYGYSPGVYVMIYDCNTAATDATRWQIWDNGTIINPRSSLVLAATSGNSGTTLTVQTNIYAVSQGWLPTNNTQPFVTTIVGLYGLCLQANSGQVWIEDCSSEKAEQQWALYADGSIRPQQNRDNCLTSDSNIRETVVKILSCGPASSGQRWMFKNDGTILNLYSGLVLDVRASDPSLKQIILYPLHGDPNQIWLPLF,negative +AAGACGGCCCGGUGUGCAGCCGGAGAUCCGAGACUUGCU,PHITDVVLDKANKTPLRQLDPSRLPDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFAKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRQSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPINRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDTASEATRPATLNRFSALQQTLPAENTDNRRVVQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRTRTPATKRSFSKEVEERSRERPSQPEGLRKAASLTEDRGRDPVKREATLPPVSPPKAALSVDEVEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRLGIESTLERSTIAREHMGRLLHQLLCAGHLSTAQYYQGLYETLELAEDMEIDIPHVWLYLAELITPILQEDGVPMGELFREITKPLRPMGKATSLLLEILGLLCKSMGPKKVGMLWREAGLSWREFLAEGQDVGSFVAEKKVEYTLGEESEAPGQRTLAFEELRRQLEKLLKDGGSNQRVFDWIDANLNEQQIASNTLVRALMTTVCYSAIIFETPLRVDVQVLKVRARLLQKYLCDEQKELQALYALQALVVTLEQPANLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFNWLREAEDEESDHN,negative +UAUCCUCGCCCGUGCACGCCCUCCACUAAGCCCA,MEPVDPRLEPWKHPGSQPKTACTNCYCKKCCFHCQVCFITKALGISYGRKKRRQRRRAHQNSQTHQASLSKQPTSQPRGDPTGPKE,negative +GGGACGCGTGGTACCGACGGAGGCTTGTTTATGTAGGGATGTAAGGGGATGGGCAATGTGGCGACAGCTT,MQPLLLLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVLTAAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRRNRNVNPVALPRAQEGLRPGTLCTVAGWGRVSMRRGTDTLREVQLRVQRDRQCLRIFGSYDPRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSGVPPEVFTRVSSFLPWIRTTMRSFKLLDQMETPL,negative +TCCCTACGGCGCTAACTCCCGATAGGAGGCCCGTGGCCGTGTTATCGCCACCGTGCTACAAC,MLSWGYFLFLLPTLPGAQSQVQLVESGGDVRKPGDSLRLSCKGSGFTFSNYWLGWVRQAPGKALNGSLPLTPLAAAPTYIPGVSGRFTISRDNARALLHLDMSDLRPEDTGRYHCER,negative +GGAGUCUUAGGCAGCGCGUUUUCGAGCUACUCCA,MAWYWWRRRRRRGWWKPRRRRWRRRRARRRGPARRHRARRRIVRHPCNGQTSSGNRVPRSVQAVDPKYVSLQLVWHSWDFRRGLFGQAGIKRMQQESDALTLSPVHRPKRPKRDTQVKEKTPEKDSDSAVQLRRLQPWIHSSQETKDEEEEIPEGPVQEQLLQQLQQQRLLRVQLESIAQEVLKIRRGHSLHPLLSSHA,negative +GTGATCGTCCAGCGACCGAGCAGGAAACTTATGTAACGACCCGAAATTCCTGCTTAGACT,WPLTEEKIKALVEICXEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEEFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDXIIYQYMDDLYVGSDLEIGQHRTKVEELRQHLLXWGFTTPDKKHQKEPPFLWMGYELHP,negative +AGACCUUAUACCUGAGAUUACACGCUCUUCGAGCACGUCGAC,MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA,negative +UAAACCUGCUGGCAGUGUGACCUAAGGACCAAGCCGUUCCUGAGGAACGUC,MCLSEGIMCSIPPYLQFVFRYPLKSYSFGTKEPNYERDRSVPARFQRLQEDFEKYGMRRSVEGILLVHEHNLPHVLLLQLGTFFKLPGGELHPGEEEIEGLKRLLSEMLGRTDGIPVDWIPEDCIGNWWRPNFEPPRYPYIPAHVTKPKEQTRLFLIQLPEKTLFAVPSNYKLVAAPLFELFDNARAYGPIISSLPQVLSRFNFAYND,negative +GGCTATAGCACATGGGTAAAACGAC,MRQTLPCIYFWGGLLPFGMLCASSTTKCTVSHEVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQALKSEELDIFANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFNPFDCTCESIAWFVNWINETHTNIPELSSHYLCNTPPHYHGFPVRLFDTSSCKDSAPFELFFMINTSILLIFIFIVLLIHFEGWRISFYWNVSVHRVLGFKEIDRQTEQFEYAAYIIHAYKDKDWVWEHFSSMEKEDQSLKFCLEERDFEAGVFELEAIVNSIKRSRKIIFVITHHLLKDPLCKRFKVHHAVQQAIEQNLDSIILVFLEEIPDYKLNHALCLRRGMFKSHCILNWPVQKERIGAFRHKLQVALGSKNSVH,negative +CAAGAACTCCTAAGTATAATGTGAGGGATCCGAAATTCTGCTCTTATGTATGGCAAGATT,MQRTKEAVKASDGNLLGDPGRIPLSKRESIKWQRPRFTRQALMRCCLIKWILSSAAPQGSDSSDSELELSTVRHQPEGLDQLQAQTKFTKKELQSLYRGFKNECPTGLVDEDTFKLIYSQFFPQGDATTYAHFLFNAFDADGNGAIHFEDFVVGLSILLRGTVHEKLKWAFNLYDINKDGCITKEEMLAIMKSIYDMMGRHTYPILREDAPLEHVERFFQKMDRNQDGVVTIDEFLETCQKDENIMNSMQLFENVI,negative +CTCCTCTGACTGTAACCACGGACTGCTGATGAGTCACTTTAACGTGGAGCAAAGATTAAAGCATAGGTAGTCCAGAAGCC,VVIRSNNFTDNAKTIIVQLNESIAINCTRPNNNTRKSIHIGPGRAFYTTGDIIGNIRQAHCNLSRTKWENTLKQIAKKLREQFGNKTIVFNH,negative +ACATGTGATGATATATCGTGTCTCGTGATA,MASTSRLDALPRVTCPNHPDAILVEDYRAGDMICPECDRVIDVGSEWRTFSNDKATKDPSRVGDSQNPLLSDGDLSTMIGKGTGAASFDEFGNSKYQNRRTMSSSDRAMMNAFKEITTMADRINLPRNIVDRTNNLFKQVYEQKSLKGRANDAIASACLYIACRQEGVPRTFKEICAVSRISKKEIGRCFKLILKALETSVDLITTGDFMSRFCSNLCLPKQVQMAATHIA,negative +GGCAGGAAGACAAACACGATGGGGGGGTATGATTTGATGTGGTTGTTGCATGATCGTGGTCTGTGGTGCTCT,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,negative +AUCAGCCAUGUUUACGUCACUCCUUGUCAAUCCUCAUCGG,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,negative +CTTTTATAGGATCGCACCTATGAATCTAATAGTCAAGTCC,MAIPKELLVLLLGIAILSKVAECAAFGSRRGLVETVFDVTRFGARPNTPADSTRGLMMAWRSACQSPGPAKVVIPPGTYTTGETIFQGPCTSPRPITIEIQGTLLSNTDMSLYTRAAWISIEHVDGIVITGGGTLNGQGKSSWQFADKSGSTPPLPSSLVFQTVRSSSIKNLNFVDAKGVHLKITDSSDISVSNIKITAPGDSPNTDGLHISDTINVNVTDSTIGTGDDCISIGDGNSNVYISNINCGPGHGISIGSLGKRLDETDVKGVTVRNCTFRGTTNGARIKTYMGSPSLQVSGVVYEDIILDNVKNPIVIDQHYHSKNRNEPSRVKLVDIHFRNIRGTTTSKIPVLLNCSEALPCEGVELVDIDLAPVGSIGPLLPATCQNAKTILNGKNNPPAC,negative +GACUAAACGCAUUGUGCCCC,MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC,negative +GGTTGGTGTGGTTGG,DHNPPTIELIQRFCSDVDMWLKEDSSNVVAVHCKAGKGRTGTMICAYLVFSGIKKSADEALAWYDEKRTKDRKGVTIPSQRRYVQYFSKLVCSSVPYSKVSLNVCEIRFSESSCVQNLGMVECSISVLHDSATENAKPDRLKTLPIDFQKSFVLTIKPSIPVSGDVKFELTKKSPDKIICHFWLNTFFVRNYSPCESDGTVNKYIHTLSKSEIDDVHKDSEHKRFSEEFKISIVFEAENFSNDVQAEASEKERNENVLNFERSDYDSLSPNCYAEKKVLTAIVNDNTTKSQTIETLDHKDIVTKIQYDTSTNSKNTSTACKRKQPNSKTLLPSLNDSTKEEIKRNHIFNQPSIKKTDLIKWQNSEVHITRSINENKNINYNSYITCKQSSPKFNCGTEDGEEDWESGESTYL,negative +CACCTTGCGAAGCATAGTAACACCCAACACGCCCCATGCG,MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICEVEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASSIVYKKEGEQVEFSFPLAFTVEKLTGSGELWWQAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLPQALPQYAGSGNLTLALEAKTGKLHQEVNLVVMRATQLQKNLTCEVWGPTSPKLMLSLKLENKEAKVSKREKAVWVLNPEAGMWQCLLSDSGQVLLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQAERMSQIKRLLSEKKTCQCPHRFQKTCSPI,negative +AGAAAAAAACAAUCCACAGAACAGCGCGUG,MAWYWWRRRRRRGWWKPRRRRWRRRRARRRGPARRHRARRRIVRHPCNGQTSSGNRVPRSVQAVDPKYVSLQLVWHSWDFRRGLFGQAGIKRMQQESDALTLSPVHRPKRPKRDTQVKEKTPEKDSDSAVQLRRLQPWIHSSQETKDEEEEIPEGPVQEQLLQQLQQQRLLRVQLESIAQEVLKIRRGHSLHPLLSSHA,negative +GGGACACAAUGGACGACUCACUAUUUGUUUUCGCGCCCAGUUGCAAAAAGUGUCGUAACGGCCGACAUGAGAG,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +GGGAAAAUAAUAAUAAA,MEDDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKEEIAEVANEIESLGSTEERKNMQRNKQVAMGRKKFNMDPKKGIQFLIENGLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERDEFSIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNTGVFQSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIKNEPFKIPVWFFLQNLYESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEDWIKCIKAAISRDPFYEMLAARKKKVSSTKRH,negative +TATAACGCCCGTGTTGCTCGGTTAT,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +GCTTTACCGCACTTCCGATCTTTAATTTCGAGTGTATCAT,PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGKISKIGPENPYNTPVFAIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDESFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPXRXKNPEMVIYQYMDDLYVGSDLEIGQHRAKIEELRSHLLSWGFTTPDKKHQKEPPFLWMGYELHPDSWTVQPIELPEKDSWTVNE,negative +AGUAAUACGACUCACUAUAGGGAGAAUUCCGACCAGAAGGGUUAGCGGUCGUCUUAAGUAGUUUUUGGUCCUUUCCUCUCUCCUUCCUCUUCU,MDSTNYISKLFEYAQRQGQISDIKFEEVGTDGPDHLKTFTLRVVIKGHAYPNGVGKTKKEAKRNAAKHALIGMMETTEQKDASVSCPPSPAPSPAPPVRAVISQPKYVSWLNEHSQKNKLSLKALEGARVGPNNTSQCCRYVVGEKEYPEGFGNTKKEAKEEAAMQVYLELCGGSQTTGTVDENCNGTTGKHKEELNGKVVVLSEKVEHMNMSPAQNVPEQYSFITTEETNFIGILNHYCQKTKRFLDFKLVEKSGPSHNPQFVYKVLIDKREYPDGLGKTAKEAKQQAAQLAWSALQEQSDWNSQVSCRSTVSEEGGLSSLTPSSTWESQDATPSSLSIAGSTSESIIFSDSVNVSSPKDESPVNVKPKIRLAANFQMSPVKTKQEGPNLKGNDLGTLSSGRTSNQPVISRFSSEFDSIENIGKGGFGHVYKARRKLEQKYFAVKIVRSKGKAKREVGALADLQHPNIVRYYTAWLEDTAYRCDTASESDTTSDSGSSSSSEFLYIQMELCDKRTLKVWIDERNAHRKPKRREESLSITQQIVNGVEYIHSKKLLHRDLKPANIMFGMSDGEGKGEVKIGDFGLVTAEDNDNDENLLERTKKTGTVSYMAPEQRNQTSYDRKVDIFALGLIYFEPLWDLSGMEKAKVWNDVRSQRFPQQFNSQFTLENKVIESLLCANPEERPDARQLKTKLNECSRVLTRVHNIHQDNRTI,negative +AUGACGUACCCGCACAAGCCACCACAAGUCUUAAUCGCGCCACCCUUGC,VVIRSNNFTDNAKTIIVQLNESIAINCTRPNNNTRKSIHIGPGRAFYTTGDIIGNIRQAHCNLSRTKWENTLKQIAKKLREQFGNKTIVFNH,negative +CAAGGCAGAAUGUAAUGCUGAAUAAGAGAGAAAAGUGUUGGUGAG,DHNPPTIELIQRFCSDVDMWLKEDSSNVVAVHCKAGKGRTGTMICAYLVFSGIKKSADEALAWYDEKRTKDRKGVTIPSQRRYVQYFSKLVCSSVPYSKVSLNVCEIRFSESSCVQNLGMVECSISVLHDSATENAKPDRLKTLPIDFQKSFVLTIKPSIPVSGDVKFELTKKSPDKIICHFWLNTFFVRNYSPCESDGTVNKYIHTLSKSEIDDVHKDSEHKRFSEEFKISIVFEAENFSNDVQAEASEKERNENVLNFERSDYDSLSPNCYAEKKVLTAIVNDNTTKSQTIETLDHKDIVTKIQYDTSTNSKNTSTACKRKQPNSKTLLPSLNDSTKEEIKRNHIFNQPSIKKTDLIKWQNSEVHITRSINENKNINYNSYITCKQSSPKFNCGTEDGEEDWESGESTYL,negative +GGGUUCGCUAAGUUGGUCUACCCCUCUCGAAUAUCCGUUA,MVKSHIGSWILVLFVAMWSDVGLCKKRPKPGGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGTHGQWNKPSKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGSDYEDRYYRENMHRYPNQVYYRPVDQYSNQNNFVHDCVNITVKEHTVTTTTKGENFTETDIKMMERVVEQMCITQYQRESQAYYQRGASVILFSSPPVILLISFLIFLIVG,negative +UGGUAGGACGGCACCGGAGAAAGGUAGCAUGAUAAGCGAGUACCUGCCGU,MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINYDEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQAVAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQGIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADMDFSALLSQISS,negative +CTCCTCTGACTGTAACCACGCCGAAGACCTTTTTAGCGTACTGAAAAGGAGTTACTCTCGCATAGGTAGTCCAGAAGCC,MAAKVASTSSEEAEGSLVTEGEMGEKALPVVYKRYICSFADCGAAYNKNWKLQAHLCKHTGEKPFPCKEEGCEKGFTSLHHLTRHSLTHTGEKNFTCDSDGCDLRFTTKANMKKHFNRFHNIKICVYVCHFENCGKAFKKHNQLKVHQFSHTQQLPYECPHEGCDKRFSLPSRLKRHEKVHAGYPCKKDDSCSFVGKTWTLYLKHVAECHQDLAVCDVCNRKFRHKDYLRDHQKTHEKERTVYLCPRDGCDRSYTTAFNLRSHIQSFHEEQRPFVCEHAGCGKCFAMKKSLERHSVVHDPEKRKLKEKCPRPKRSLASRLTGYIPPKSKEKNASVSGTEKTDSLVKNKPSGTETNGSLVLDKLTIQ,negative +UGUAGUUUCCCUGUAUGC,MELAAWCRWGFLLALLPPGIAGTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYVPANASLSFLQDIQEVQGYMLIAHNQVKRVPLQRLRIVRGTQLFEDKYALAVLDNRDPQDNVAASTPGRTPEGLRELQLRSLTEILKGGVLIRGNPQLCYQDMVLWKDVFRKNNQLAPVDIDTNRSRACPPCAPACKDNHCWGESPEDCQILTGTICTSGCARCKGRLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMHNPEGRYTFGASCVTTCPYNYLSTEVGSCTLVCPPNNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLRGARAITSDNVQEFDGCKKIFGSLAFLPESFDGDPSSGIAPLRPEQLQVFETLEEITGYLYISAWPDSLRDLSVFQNLRIIRGRILHDGAYSLTLQGLGIHSLGLRSLRELGSGLALIHRNAHLCFVHTVPWDQLFRNPHQALLHSGNRPEEDLCVSSGLVCNSLCAHGHCWGPGPTQCVNCSHFLRGQECVEECRVWKGLPREYVSDKRCLPCHPECQPQNSSETCFGSEADQCAACAHYKDSSSCVARCPSGVKPDLSYMPIWKYPDEEGICQPCPINCTHSCVDLDERGCPAEQRASPVTFIIATVVGVLLFLILVVVVGILIKRRRQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVREHRGRLGSQDLLNWCVQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPSSPMDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFSPDPTPGTGSTAHRRHRSSSTRSGGGELTLGLEPSEEGPPRSPLAPSEGAGSDVFDGDLAMGVTKGLQSLSPHDLSPLQRYSEDPTLPLPPETDGYVAPLACSPQPEYVNQSEVQPQPPLTPEGPLPPVRPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLVPREGTASPPHPSPAFSPAFDNLYYWDQNSSEQGPPPSNFEGTPTAENPEYLGLDVPV,negative +GGGAGGACGCGUCGCCGUAAUGGAUGUUUUGCUCCCUG,MDKLVVNYYEYKHPIINKDLAIGAHGGKKFPTLGAWYDVINEYEFQTRCPIILKNSHRNKHFTFACHLKNCPFKVLLSYAGNAASSETSSPSANNNTNPPGTPDHIHHHSNNMNNEDNDNNNGSNNKVSNDSKLDFVTDDLEYHLANTHPDDTNDKVESRSNEVNGNNDDDADANNIFKQQGVTIKNDTEDDSINKASIDRGLDDESGPTHGNDSGNHRHNEEDDVHTQMTKNYSDVVNDEDINVAIANAVANVDSQSNNKHDGKDDDATNNNDGQDNNTNNDHNNNSNINNNNVGSHGISSHSPSSIRDTSMNLDVFNSATDDIPGPFVVTKIEPYHSHPLEDNLSLGKFILTKIPKILQNDLKFDQILESSYNNSNHTVSKFKVSHYVEESGLLDILMQRYGLTAEDFEKRLLSQIARRITTYKARFVLKKKKMGEYNDLQPSSSSNNNNNNDGELSGTNLRSNSIDYAKHQEISSAGTSSNTTKNVNNNKNDSNDDNNGNNNNDASNLMESVLDKTSSHRYQPKKMPSVNKWSKPDQITHSDVSMVGLDESNDGGNENVHPTLAEVDAQEARETAQLAIDKINSYKRSIDDKNGDGHNNSSRNVVDENLINDMDSEDAHKSKRQHLSDITLEERNEDDKLPHEVAEQLRLLSSHLKEVENLHQNNDDDVDDVMVDVDVESQYNKNTTHHNNHHSQPHHDEEDVAGLIGKADDEEDLSDENIQPELRGQ,negative +ACAUUCCAAAUUACCCACCCACUGCUCCUAUCUG,MDHLNEATQGKEHSEMSNNVSDPKGPPAKIARLEQNGSPLGRGRLGSTGAKMQGVPLKHSGHLMKTNLRKGTMLPVFCVVEHYENAIEYDCKEEHAEFVLVRKDMLFNQLIEMALLSLGYSHSSAAQAKGLIQVGKWNPVPLSYVTDAPDATVADMLQDVYHVVTLKIQLHSCPKLEDLPPEQWSHTTVRNALKDLLKDMNQSSLAKECPLSQSMISSIVNSTYYANVSAAKCQEFGRWYKHFKKTKDMMVEMDSLSELSQQGANHVNFGQQPVPGNTAEQPPSPAQLSHGSQPSVRTPLPNLHPGLVSTPISPQLVNQQLVMAQLLNQQYAVNRLLAQQSLNQQYLNHPPPVSRSMNKPLEQQVSTNTEVSSEIYQWVRDELKRAGISQAVFARVAFNRTQGLLSEILRKEEDPKTASQSLLVNLRAMQNFLQLPEAERDRIYQDERERSLNAASAMGPAPLISTPPSRPPQVKTATIATERNGKPENNTMNINASIYDEIQQEMKRAKVSQALFAKVAATKSQGWLCELLRWKEDPSPENRTLWENLSMIRRFLSLPQPERDAIYEQESNAVHHHGDRPPHIIHVPAEQIQQQQQQQQQQQQQQQAPPPPQPQQQPQTGPRLPPRQPTVASPAESDEENRQKTRPRTKISVEALGILQSFIQDVGLYPDEEAIQTLSAQLDLPKYTIIKFFQNQRYYLKHHGKLKDNSGLEVDVAEYKEEELLKDLEESVQDKNTNTLFSVKLEEELSVEGNTDINTDLKD,negative +AUCAGUCCCCACUGCCCCCGCUUGCAGACA,WWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMKSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGSKGKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMKVAKNAQNINPTSLQNSQNFA,negative +CTCCTCTGACTGTAACCACGCCCATAGCGGTGAATGCATGAGCAACCCGATTGACACGGGGCATAGGTAGTCCAGAAGCC,MKKRKVLIPLMALSTILVSSTGNLEVIQAEVKQENRLLNESESSSQGLLGYYFSDLNFQAPMVVTSSTTGDLSIPSSELENIPSENQYFQSAIWSGFIKVKKSDEYTFATSADNHVTMWVDDQEVINKASNSNKIRLEKGRLYQIKIQYQRENPTEKGLDFKLYWTDSQNKKEVISSDNLQLPELKQKSSNSRKKRSTSAGPTVPDRDNDGIPDSLEVEGYTVDVKNKRTFLSPWISNIHEKKGLTKYKSSPEKWSTASDPYSDFEKVTGRIDKNVSPEARHPLVAAYPIVHVDMENIILSKNEDQSTQNTDSQTRTISKNTSTSRTHTSEVHGNAEVHASFFDIGGSVSAGFSNSNSSTVAIDHSLSLAGERTWAETMGLNTADTARLNANIRYVNTGTAPIYNVLPTTSLVLGKNQTLATIKAKENQLSQILAPNNYYPSKNLAPIALNAQDDFSSTPITMNYNQFLELEKTKQLRLDTDQVYGNIATYNFENGRVRVDTGSNWSEVLPQIQETTARIIFNGKDLNLVERRIAAVNPSDPLETTKPDMTLKEALKIAFGFNEPNGNLQYQGKDITEFDFNFDQQTSQNIKNQLAELNATNIYTVLDKIKLNAKMNILIRDKRFHYDRNNIAVGADESVVKEAHREVINSSTEGLLLNIDKDIRKILSGYIVEIEDTEGLKEVINDRYDMLNISSLRQDGKTFIDFKKYNDKLPLYISNPNYKVNVYAVTKENTIINPSENGDTSTNGIKKILIFSKKGYEIG,negative +GTAAATCGTCGACAGGAATTGGCGGGCCGG,MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH,negative +CAGUCGUCAUGGUUAUAGCUGCCACAACCUCGGUCCUGUCUUCAACGGCC,MNQVTIQWDAVIALYILFSWCHGGITNINCSGHIWVEPATIFKMGMNISIYCQAAIKNCQPRKLHFYKNGIKERFQITRINKTTARLWYKNFLEPHASMYCTAECPKHFQETLICGKDISSGYPPDIPDEVTCVIYEYSGNMTCTWNAGKLTYIDTKYVVHVKSLETEEEQQYLTSSYINISTDSLQGGKKYLVWVQAANALGMEESKQLQIHLDDIVIPSAAVISRAETINATVPKTIIYWDSQTTIEKVSCEMRYKATTNQTWNVKEFDTNFTYVQQSEFYLEPNIKYVFQVRCQETGKRYWQPWSSLFFHKTPETVPQVTSKAFQHDTWNSGLTVASISTGHLTSDNRGDIGLLLGMIVFAVMLSILSLIGIFNRSFRTGIKRRILLLIPKWLYEDIPNMKNSNVVKMLQENSELMNNNSSEQVLYVDPMITEIKEIFIPEHKPTDYKKENTGPLETRDYPQNSLFDNTTVVYIPDLNTGYKPQISNFLPEGSHLSNNNEITSLTLKPPVDSLDSGNNPRLQKHPNFAFSVSSVNSLSNTIFLGELSLILNQGECSSPDIQNSVEEETTMLLENDSPSETIPEQTLLPDEFVSCLGIVNEELPSINTYFPQNILESHFNRISLLEK,negative +AATACGACTCACTATAGAGGGAGGACGATGCGGGGTGCTTCGAGCGTAGGAAGAAAGCCGGGGGCTGCAGATAATGTATAGCCAGACGACGGA,MNIKAILSLCLFLILQCVRARVFVSRLEAASLLARSRRANSPFSMEETKQGSLERECREETCNFEEAREIFEDDQRTNAFWTLYIRPNPCLSNPCQNGGTCQHTHTVYMCVCPRGWEGRVCSQEVSTGQSCKVNNGRCDHYCEEEEAAAGGRRGAVCSCAPGYHLARNRRSCMAMEAFPCGRVASPKSDILMGNSSEAATDVPTPTSQAANVNSSSIIGDDSEPQASFGHSNHRGRVVGGKECPRGQCPWQVLISRKGAPVCGGTILSPQWILTAAHCTIYETKNLRILAGEHNVDEVEGSEQELGILRIVDHPSFNIKLSYDNDISLIQLSRPIQFTRYALPICLPNQRFVRGVLRSVVAGTVSGWGKLNEFGPAAGILQRLEVPYVDDEQCRAAMGSKVITANMFCAGYETGGQDSCSGDSGGPHATRYGSTWFLTGVVSWGKGCAREGKFGVYTKVLNYLDWIAQTMAETESHALPEPAQH,negative +TATTAGTAATACTATTAGTAATAC,MRKIVVAAIAVSLTTVSITASASADPSKDSKAQVSAAEAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKVKPSAASIDAAKKAGVNNGNPLDAVQQ,negative +AAGACGGCCGGGGAAACCCGAGAUCCGAGGUAACGC,MPVKMVAVLGASTVLWILFAVSQAFKIEISPEYKTIAQIGDSMALTCSTTGCESPLFSWRTQIDSPLNAKVRTEGSKSVLTMEPVSFENEHSYLCTATCGSGKLERSIHVDIYSFPKDPEIQFSGPLEVGKPVTVKCLAPDIYPVYRLEIDLFKGDQLMNRQEFSSEEMTKSLETKSLEVTFTPVIEDIGKALVCRAKLHIDQIDSTLKERETVKELQVYISPRNTTISVHPSTRLQEGGAVTMTCSSEGLPAPEIFWGRKLDNEVLQLLSGNATLTLIAMRMEDSGVYVCEGVNLIGRDKAEVELVVQEKPFIVDISPGSQVAAQVGDSVVLTCAAIGCDSPSFSWRTQTDSPLNGVVRNEGAKSTLVLSSVGFEDEHSYLCAVTCLQRTLEKRTQVEVYSFPEDPVIKMSGPLVHGRPVTVNCTVPNVYPFDHLEIELLKGETTLMKKYFLEEMGIKSLETKILETTFIPTIEDTGKSLVCLARLHSGEMESEPKQRQSVQPLYVNVAPKETTIWVSPSPILEEGSPVNLTCSSDGIPAPKILWSRQLNNGELQPLSENTTLTFMSTKRDDSGIYVCEGINEAGISRKSVELIIQVSPKDIQLTVFPSKSVKEGDTVIISCTCGNVPETWIILKKKAKTGDMVLKSVDGSYTIRQAQLQDAGIYECESKTEVGSQLRSLTLDVKGKEHNKDYFSPELLALYCASSLVIPAIGMIVYFARKANMKGSYSLVEAQKSKV,negative +GGCAGCGAGAGCAAAACAAGUAUGAGACCCAGCUACGGCGACUUCUCAUGCGUAGCCAAACCCA,IMEIRTVAVGIVAIKGVESEYYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHSGGEMFVALNQKGLPVKGKKTKKEQKTAHFLPMAIT,negative +GGGUUACCUAGGUGUAGAUGCUCUUCAGAUUCAUUUAUAAGAUCCGACAACCUGUCUAUUAGUUGCGCCGAUUAAGUGACGUCUGAACUGCUUCGAA,MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYTFLLPEMDNCRSSSSPYVSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQDNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVLVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF,negative +CCCGGUUACCGUGUUUGUUCUGCUAGAUUUUGGUU,MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPGPHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR,negative +CTTCGGCTTCACAGCTTTGGAAAGGGTACAAATTAAACTA,MLSWGYFLFLLPTLPGAQSQVQLVESGGDVRKPGDSLRLSCKGSGFTFSNYWLGWVRQAPGKALNGSLPLTPLAAAPTYIPGVSGRFTISRDNARALLHLDMSDLRPEDTGRYHCER,negative +GCAACAGAGGCUGAUGGUAGACGCCGGCCA,MARVRGPRLPGCLALAALFSLVHSQHVFLAHQQASSLLQRARRANKGFLEEVRKGNLERECLEEPCSREEAFEALESLSATDAFWAKYTACESARNPREKLNECLEGNCAEGVGMNYRGNVSVTRSGIECQLWRSRYPHKPEINSTTHPGADLRENFCRNPDGSITGPWCYTTSPTLRREECSVPVCGQDRVTVEVIPRSGGSTTSQSPLLETCVPDRGREYRGRLAVTTSGSRCLAWSSEQAKALSKDQDFNPAVPLAENFCRNPDGDEEGAWCYVADQPGDFEYCDLNYCEEPVDGDLGDRLGEDPDPDAAIEGRTSEDHFQPFFNEKTFGAGEADCGLRPLFEKKQVQDQTEKELFESYIEGRIVEGQDAEVGLSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTVDDLLVRIGKHSRTRYERKVEKISMLDKIYIHPRYNWKENLDRDIALLKLKRPIELSDYIHPVCLPDKQTAAKLLHAGFKGRVTGWGNRRETWTTSVAEVQPSVLQVVNLPLVERPVCKASTRIRITDNMFCAGYKPGEGKRGDACEGDSGGPFVMKSPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDRLGS,negative +AAGCTCTTAGTTGATGCGCGGTCAAAATTTAAGCT,MAWYWWRRRRRRGWWKPRRRRWRRRRARRRGPARRHRARRRIVRHPCNGQTSSGNRVPRSVQAVDPKYVSLQLVWHSWDFRRGLFGQAGIKRMQQESDALTLSPVHRPKRPKRDTQVKEKTPEKDSDSAVQLRRLQPWIHSSQETKDEEEEIPEGPVQEQLLQQLQQQRLLRVQLESIAQEVLKIRRGHSLHPLLSSHA,negative +GGAATGAGTGCCCTGCAAGCGAGGGCTAGC,MDHLNEATQGKEHSEMSNNVSDPKGPPAKIARLEQNGSPLGRGRLGSTGAKMQGVPLKHSGHLMKTNLRKGTMLPVFCVVEHYENAIEYDCKEEHAEFVLVRKDMLFNQLIEMALLSLGYSHSSAAQAKGLIQVGKWNPVPLSYVTDAPDATVADMLQDVYHVVTLKIQLHSCPKLEDLPPEQWSHTTVRNALKDLLKDMNQSSLAKECPLSQSMISSIVNSTYYANVSAAKCQEFGRWYKHFKKTKDMMVEMDSLSELSQQGANHVNFGQQPVPGNTAEQPPSPAQLSHGSQPSVRTPLPNLHPGLVSTPISPQLVNQQLVMAQLLNQQYAVNRLLAQQSLNQQYLNHPPPVSRSMNKPLEQQVSTNTEVSSEIYQWVRDELKRAGISQAVFARVAFNRTQGLLSEILRKEEDPKTASQSLLVNLRAMQNFLQLPEAERDRIYQDERERSLNAASAMGPAPLISTPPSRPPQVKTATIATERNGKPENNTMNINASIYDEIQQEMKRAKVSQALFAKVAATKSQGWLCELLRWKEDPSPENRTLWENLSMIRRFLSLPQPERDAIYEQESNAVHHHGDRPPHIIHVPAEQIQQQQQQQQQQQQQQQAPPPPQPQQQPQTGPRLPPRQPTVASPAESDEENRQKTRPRTKISVEALGILQSFIQDVGLYPDEEAIQTLSAQLDLPKYTIIKFFQNQRYYLKHHGKLKDNSGLEVDVAEYKEEELLKDLEESVQDKNTNTLFSVKLEEELSVEGNTDINTDLKD,negative +AGGAGAAUUAUGAGCGGGACAACUUCGUUCCGUGUUCGCGUACUGAGCGC,MLNQLDNLTERVRGSNKLVDRWLHVRKHLLVAYYNLVGIKPGKESYMRLNEKALDDFCQSLVDYLSAGHFSIYERILHKLEGNGQLARAAKIWPQLEANTQQIMDYYDSSLETAIDHDNYLEFQQVLSDIGEALEARFVLEDKLILLVLDAARVKHPA,negative +GAAUCAAUACACAGUCCUGGGUGCUAACCAUGAACACCCAAGGCCUUAGUGGUAUGUGGUUAUUG,MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC,negative +AGAAAAAAACAAUCCACAGAACAGCGCGUG,MDSTNYISKLFEYAQRQGQISDIKFEEVGTDGPDHLKTFTLRVVIKGHAYPNGVGKTKKEAKRNAAKHALIGMMETTEQKDASVSCPPSPAPSPAPPVRAVISQPKYVSWLNEHSQKNKLSLKALEGARVGPNNTSQCCRYVVGEKEYPEGFGNTKKEAKEEAAMQVYLELCGGSQTTGTVDENCNGTTGKHKEELNGKVVVLSEKVEHMNMSPAQNVPEQYSFITTEETNFIGILNHYCQKTKRFLDFKLVEKSGPSHNPQFVYKVLIDKREYPDGLGKTAKEAKQQAAQLAWSALQEQSDWNSQVSCRSTVSEEGGLSSLTPSSTWESQDATPSSLSIAGSTSESIIFSDSVNVSSPKDESPVNVKPKIRLAANFQMSPVKTKQEGPNLKGNDLGTLSSGRTSNQPVISRFSSEFDSIENIGKGGFGHVYKARRKLEQKYFAVKIVRSKGKAKREVGALADLQHPNIVRYYTAWLEDTAYRCDTASESDTTSDSGSSSSSEFLYIQMELCDKRTLKVWIDERNAHRKPKRREESLSITQQIVNGVEYIHSKKLLHRDLKPANIMFGMSDGEGKGEVKIGDFGLVTAEDNDNDENLLERTKKTGTVSYMAPEQRNQTSYDRKVDIFALGLIYFEPLWDLSGMEKAKVWNDVRSQRFPQQFNSQFTLENKVIESLLCANPEERPDARQLKTKLNECSRVLTRVHNIHQDNRTI,negative +AAGAAGGACAGCACGAAUAAAACCUGCGUAAAUCCGCCCCAUUUGUGUAAGGGUAGUGGG,MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP,negative +GGAGCGCAAUUCGCCUCGCAAGUUGAACUCCGCUGGCGG,MPSNQEARLFLAVLVLAQVLPILVDSAAEKGFKQAFWQPLCQVSEELDDQPKGALFTLQAAASKIQKMRDAALRASIYAEINHGTNRAKAAVIVANHYAMKADSGLEALKQTLSSQEVTATATASYLKGRIDEYLNLLLQTKESGTSGCMMDTSGTNTVTKAGGTIGGVPCKLQLSPIQPKRPAATYLGKAGYVGLTRQADAANNFHDNDAECRLASGHNTNGLGKSGQLSAAVTMAAGYVTVANSQTAVTVQALDALQEASGAAHQPWIDAWKAKKALTGAETAEFRNETAGIAGKTGVTKLVEEALLKKKDSEASEIQTELKKYFSGHENEQWTAIEKLISEQPVAQNLVGDNQPTKLGELEGNAKLTTILAYYRMETAGKFEVLTQKHKPAESQQQAAETEGSCNKKDQNECKSPCKWHNDAENKKCTLDKEEAKKVADETAKDGKTGNTNTTGSSNSFVISKTPLWLAVLLF,negative +TCTCATGCGTCGAGTGTGAGTTTAACTGCGT,MSARGEEAAGEASGSQEQPEPALAEPKKRGPGRPRKPQQEPTGEPVPKRPRGRPKGSKNKGPSKAAQKKAETTGEKRPRGRPRKWPQQVVQEKPAQEEEEEEEEEEAEED,negative +GCTTTACCGCACTTCCGATCTTTAATTTCGAGTGTATCAT,MEGMLKGEGPGPLPPLLQQYVELRDQYPDYLLLFQVGDFYECFGEDAERLARALGLVLTHKTSKDFTTPMAGIPLRAFEAYAERLLKMGFRLAVADQVEPAEEAEGLVRREVTQLLTPGTLLQESLLPREANYLAAIATGDGWGLAFLDVSTGEFKGTVLKSKSALYDELFRHRPAEVLLAPELLENGAFLDEFRKRFPVMLSEAPFEPEGEGPLALRRARGALLAYAQRTQGGALSLQPFRFYDPGAFMRLPEATLRALEVFEPLRGQDTLFSVLDETRTAPGRRLLQSWLRHPLLDRGPLEARLDRVEGFVREGALREGVRRLLYRLADLERLATRLELGRASPKDLGALRRSLQILPELRALLGEEVGLPDLSPLKEELEAALVEDPPLKVSEGGLIREGYDPDLDALRAAHREGVAYFLELEERERERTGIPTLKVGYNAVFGYYLEVTRPYYERVPKEYRPVQTLKDRQRYTLPEMKEKEREVYRLEALIRRREEEVFLEVRERAKRQAEALREAARILAELDVYAALAEVAVRYGYVRPRFGDRLQIRAGRHPVVERRTEFVPNDLEMAHELVLITGPNMAGKSTFLRQTALIALLAQVGSFVPAEEAHLPLFDGIYTRIGASDDLAGGKSTFMVEMEEVALILKEATENSLVLLDEVGRGTSSLDGVAIATAVAEALHERRAYTLFATHYFELTALGLPRLKNLHVAAREEAGGLVFYHQVLPGPASKSYGVEVAAMAGLPKEVVARARALLQAMAARREGALDAVLERLLALDPDRLTPLEALRLLQELKALALGAPLDTMKG,negative +UUAACCAUCAGCUCAUGGCCCCUGCCCUCUCAAGGACCAC,MASNFTQFVLVDNGGTGDVTVAPSNFANGVAEWISSNSRSQAYKVTCSVRQSSAQNRKYTIKVEVPKVATQTVGGVELPVAAWRSYLNMELTIPIFATNSDCELIVKAMQGLLKDGNPIPSAIAANSGIY,negative +AACAUAUCCCCAGCCAUGCAACGUGGCGAA,PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGKISKIGPENPYNTPVFAIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDESFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPXRXKNPEMVIYQYMDDLYVGSDLEIGQHRAKIEELRSHLLSWGFTTPDKKHQKEPPFLWMGYELHPDSWTVQPIELPEKDSWTVNE,negative +AGUAAUACGACUCACUAUAGGGAGAAUUCCGACCAGAAGGGUUAGCGGUCGUCUUAAGUAGUUUUUGGUCCUUUCCUCUCUCCUUCCUCUUCU,QSVEESRGGLIKPTDTLTLTCTVSGFSLSSYGEVWDRQAPGNGLEYIGAIGNSGSTYYASWAKSRSTITRNTNLNTVTLKMTSLTAADTATYFCAR,negative +GCCACGAUCACGGGC,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,negative +AGCCAGTCAAGTTAATGGGTGCCATGCAGAAGCA,IMEIRTVAVGIVAIKGVESEYYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHSGGEMFVALNQKGLPVKGKKTKKEQKTAHFLPMAIT,negative +AAAAAGGAGGAGGAGGA,MLDLFADAEPWQEPLAAGAVILRRFAFNAAEQLIRDINDVASQSPFRQMVTPGGYTMSVAMTNCGHLGWTTHRQGYLYSPIDPQTNKPWPAMPQSFHNLCQRAATAAGYPDFQPDACLINRYAPGAKLSLHQDKDEPDLRAPIVSVSLGLPAIFQFGGLKRNDPLKRLLLEHGDVVVWGGESRLFYHGIQPLKAGFHPLTIDCRYNLTFRQAGKKE,negative +UAUCCUCCAGAGCAUCGCCGUCCAUAACCACUUACCUCCU,MIPPPRRSASSTPKDYRSSRDLQPWRGVSSGDAAETSQQSRHRRDAIADGGGRLKGAAQSSPSSGTRRSGPYAQGRAMPKNENIPKPGKQRLGPRKKKLSTLKKKILLDRLERWRDKQHEGALSTPSATASSEEAKCNNPFPLCPPGELSPPPSPPATICPAVVDKSTSYGQVGGANGERSVWAITIYNLVDQEDVEDDDDHAEIERDLWDMSSAFGVVRSVQVPRGTAVQVSDAEVSAAAAAGEPAAVAAKVAFATNAEAECARDGLNGRIVGGKPLLVRIHRCDGHFCGGVCPGDPDGSGLWRVAIENLIDEEDDLDDEDEYAEISANVSAMMGCYGKLVDVQVRRSSPSKGEVQEDVATRAATTAGATQAVVVTFGSLAEAEACVQGIKGCRVGGKELDAHVVLDSERVLPSNPAFKCDQEHAHSSDVAAAVAGQGDSMMKQEAGTEPSPCVDQDTAAAVASSTEWRVVIRGLIDEDDLQDDDDDYAEVCSDVTALVSSYGAVVGLDIPRGRETGSCCYGAEPGEAVVVFRSLQEAEACARGLSGRKVAGNILDAQVLTQPAPSQQGPLQGGASGTGPPVANRERKPAKECPLPQHQASSHQSCGKVPELDGSGPGMLRGFGNRVEDCCGRPKIACTDSDEPQAIAAAAPPGQSIEGPKTTALAKAGKRIQTKYQEAAALPKPPGVRGGLPNAYVNQPPDKEVNDLVFEMLQLLFKFQERARLSDPSKAKTRRRLVIGLREVLRGVKAKKVRLLIVAPNVDAVGGEGGLDDKVVEIIDKAREAEYPVVFALSKRKIGKALGKTIKVSAVGVYSFDGANEQQKQLKRRMETISSLPSPSPRQSDPPTDDALASPPSSSACGDSQDPAGKGSRV,negative +TGCAGATGCAAGGTAACCATATCCAAAGCA,MRKIVVAAIAVSLTTVSITASASADPSKDSKAQVSAAEAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKVKPSAASIDAAKKAGVNNGNPLDAVQQ,negative +CACUCAGCGCCCUGCGAAACGUUGCCGCCUCCCAACGUCU,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +GCCACGAUCACGGGC,MIPPPRRSASSTPKDYRSSRDLQPWRGVSSGDAAETSQQSRHRRDAIADGGGRLKGAAQSSPSSGTRRSGPYAQGRAMPKNENIPKPGKQRLGPRKKKLSTLKKKILLDRLERWRDKQHEGALSTPSATASSEEAKCNNPFPLCPPGELSPPPSPPATICPAVVDKSTSYGQVGGANGERSVWAITIYNLVDQEDVEDDDDHAEIERDLWDMSSAFGVVRSVQVPRGTAVQVSDAEVSAAAAAGEPAAVAAKVAFATNAEAECARDGLNGRIVGGKPLLVRIHRCDGHFCGGVCPGDPDGSGLWRVAIENLIDEEDDLDDEDEYAEISANVSAMMGCYGKLVDVQVRRSSPSKGEVQEDVATRAATTAGATQAVVVTFGSLAEAEACVQGIKGCRVGGKELDAHVVLDSERVLPSNPAFKCDQEHAHSSDVAAAVAGQGDSMMKQEAGTEPSPCVDQDTAAAVASSTEWRVVIRGLIDEDDLQDDDDDYAEVCSDVTALVSSYGAVVGLDIPRGRETGSCCYGAEPGEAVVVFRSLQEAEACARGLSGRKVAGNILDAQVLTQPAPSQQGPLQGGASGTGPPVANRERKPAKECPLPQHQASSHQSCGKVPELDGSGPGMLRGFGNRVEDCCGRPKIACTDSDEPQAIAAAAPPGQSIEGPKTTALAKAGKRIQTKYQEAAALPKPPGVRGGLPNAYVNQPPDKEVNDLVFEMLQLLFKFQERARLSDPSKAKTRRRLVIGLREVLRGVKAKKVRLLIVAPNVDAVGGEGGLDDKVVEIIDKAREAEYPVVFALSKRKIGKALGKTIKVSAVGVYSFDGANEQQKQLKRRMETISSLPSPSPRQSDPPTDDALASPPSSSACGDSQDPAGKGSRV,negative +CAAGAACTCCTAAGTATAATGTGAGGGATCCGAAATTCTGCTCTTATGTATGGCAAGATT,MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINYDEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQAVAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQGIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADMDFSALLSQISS,negative +GGGCGAAUUCAACUGCCAUCUAGGCAGUAACCAGGAGUUAGUAGGACAAGUUUCGUCC,MRKIVVAAIAVSLTTVSITASASADPSKDSKAQVSAAEAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKVKPSAASIDAAKKAGVNNGNPLDAVQQ,negative +GCCAGCATCCCGACTGGGCTCCTCGATAACGAGTGCCCG,MEDLVVEVRGSNGAFYKAFVKDVHEDSITVAFENNWQPDRQIPFHDVRFPPPVGYNKDINESDEVEVYSRANEKEPCCWWLAKVRMIKGEFYVIEYAACDATYNEIVTIERLRSVNPNKPATKETFHKIKLDVPEDLRQMCAKESAHKDFKKAVGAFSVTYDPENYQLVVLSISEVTSKRAHMLIDMHFRSLRTKLSLILRNEEASKQLESSRQLASRFHEQFVVREDLMGLAIGTHGANIQQARKVPGVTAIDLDEDTCTFHIYGEDQDAVKKARSFLEFAEDVIQVPRNLVGKVIGKKKKK,negative +ATACCAGTCTATTCAATTGGGCCCTTTTCTGTGTCTTTCTGTGCCCTTAGATAGTATGTGCAATCA,MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYTFLLPEMDNCRSSSSPYVSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQDNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVLVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF,negative +AAGACGGCCCCCGCCAAUCAAGGGAGAUCCGAGGAAUUGG,MDKLVVNYYEYKHPIINKDLAIGAHGGKKFPTLGAWYDVINEYEFQTRCPIILKNSHRNKHFTFACHLKNCPFKVLLSYAGNAASSETSSPSANNNTNPPGTPDHIHHHSNNMNNEDNDNNNGSNNKVSNDSKLDFVTDDLEYHLANTHPDDTNDKVESRSNEVNGNNDDDADANNIFKQQGVTIKNDTEDDSINKASIDRGLDDESGPTHGNDSGNHRHNEEDDVHTQMTKNYSDVVNDEDINVAIANAVANVDSQSNNKHDGKDDDATNNNDGQDNNTNNDHNNNSNINNNNVGSHGISSHSPSSIRDTSMNLDVFNSATDDIPGPFVVTKIEPYHSHPLEDNLSLGKFILTKIPKILQNDLKFDQILESSYNNSNHTVSKFKVSHYVEESGLLDILMQRYGLTAEDFEKRLLSQIARRITTYKARFVLKKKKMGEYNDLQPSSSSNNNNNNDGELSGTNLRSNSIDYAKHQEISSAGTSSNTTKNVNNNKNDSNDDNNGNNNNDASNLMESVLDKTSSHRYQPKKMPSVNKWSKPDQITHSDVSMVGLDESNDGGNENVHPTLAEVDAQEARETAQLAIDKINSYKRSIDDKNGDGHNNSSRNVVDENLINDMDSEDAHKSKRQHLSDITLEERNEDDKLPHEVAEQLRLLSSHLKEVENLHQNNDDDVDDVMVDVDVESQYNKNTTHHNNHHSQPHHDEEDVAGLIGKADDEEDLSDENIQPELRGQ,negative +CCCAAUUCCGACCUGCGUCUACGUAACCUGCCAUCG,MTSHYVIAIFALMSSCLATAGPEPGALCELSPVSASHPVQALMESFTVLSGCASRGTTGLPQEVHVLNLRTAGQGPGQLQREVTLHLNPISSVHIHHKSVVFLLNSPHPLVWHLKTERLATGVSRLFLVSEGSVVQFSSANFSLTAETEERNFPHGNEHLLNWARKEYGAVTSFTELKIARNIYIKVGEDQVFPPKCNIGKNFLSLNYLAEYLQPKAAEGCVMSSQPQNEEVHIIELITPNSNPYSAFQVDITIDIRPSQEDLEVVKNLILILKCKKSVNWVIKSFDVKGSLKIIAPNSIGFGKESERSMTMTKSIRDDIPSTQGNLVKWALDNGYSPITSYTMAPVANRFHLRLENNAEEMGDEEVHTIPPELRILLDPGALPALQNPPIRGGEGQNGGLPFPFPDISRRVWNEEGEDGLPRPKDPVIPSIQLFPGLREPEEVQGSVDIALSVKCDNEKMIVAVEKDSFQASGYSGMDVTLLDPTCKAKMNGTHFVLESPLNGCGTRPRWSALDGVVYYNSIVIQVPALGDSSGWPDGYEDLESGDNGFPGDMDEGDASLFTRPEIVVFNCSLQQVRNPSSFQEQPHGNITFNMELYNTDLFLVPSQGVFSVPENGHVYVEVSVTKAEQELGFAIQTCFISPYSNPDRMSHYTIIENICPKDESVKFYSPKRVHFPIPQADMDKKRFSFVFKPVFNTSLLFLQCELTLCTKMEKHPQKLPKCVPPDEACTSLDASIIWAMMQNKKTFTKPLAVIHHEAESKEKGPSMKEPNPISPPIFHGLDTLTVMGIAFAAFVIGALLTGALWYIYSHTGETAGRQQVPTSPPASENSSAAHSIGSTQSTPCSSSSTA,negative +ATTGACCGCTGTGTGACGCAACACTCAAT,MPEEWVRIFGEAGITQFEQQRNPRLCLSVLNILSKSEHPQEKFMFVPYEQSALPVTDNSPFGDTSITHNYADHHFKASTPENEGSSFYSRVPGPCTVGVRSSSLSSGRGSSEGVGSRSGSGSGGAASRSSSSGHGGAGFPLPVTSVPANGRSSAPGPNSMTVTSGSHSSSGSNCSTGSLTGGMELTNTMVATTQRTGPNNVLVNGHSTGNHFHGGVTQRVAASAAPTECNVLPTYTGSSSSYQPTSFQSMAVHTPPAYTLRQIPPAHSIGYPYTSTAPTSESIILTAPTTTPSSTVYHTTQGSAIVKPLSDNQSQRDKLPYLMHKSQWHSNVTGHVPLSPGLPRRFVDGVLPPETSAHIQYSSGQSSPSPAGSATPVPTPRRESLAGSVPVRAGPAPPALATHELSSDANCTLTPPPVATRPEKTKSIYTKPVEAQCDGHLTIGDQQDASRRSLETPVPPQTAATIHGSENETRTNVTVLPTVHSDGNNSSVHAYQQATESRPLKPNTLERQGQKKVRPKISDEAIQEKLRMIVSIGDPNRKYQRQEKIGQGASGTVYGGIEVATGRRVAIKQMNLKQQPKKELIVNEIYVMKAKKHPNVVNYLDSYLVADELWVVMEYLDGGSLTEVVTETYMEEGQIAAVCRECLQALDFLHKNQVIHRDIKSDNILLGLDGSVKLTDFGFCAQLSSEQNKRSTMVGTPYWMAPEVVTRKQYGPKVDIWSLGIMAIEMLDGEPPYLNENPVRALYLIGTNGKPEIKERDKLSSEFQDFLDLCLEVKVERRATAQELLQHIFSRDGHRAMELLQTDNFHSSGVRKKRTPRLAIEKLVDPEVKRNYQNQLVECLPDGTVSDINGHWEKISKALLKPRRTVVMAAGEDELVVTVRGTSFNCPPTSLVEPNTGIIAPLIEPHHRGIGSYALEVVADIIGTLDYCGIAFLTMGSFVPYLYYSFYCVLWLKLFYLALIFALGSGAIAVSMSNTFASPAYRPLRALVFIALGLSGVIPCVHVTITNGFWPSLQHGSLGWLFLMAVLYITGASIYAVRVPERIFPGRFDIWFQSHQIFHVFVVAAALVHYHGIIGLTNYRLAIGDCRPPPGYPFPKHDYDNIELLRPFMTY,negative +CCGTAGGTTCGGGGCGGAGTGGTCCGGAAGGTGGCGTGG,MSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA,negative +CACCUACUAGACCACUUUUUGAGCCGGUUUUUUCGGGAACUUGCCAA,MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINYDEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQAVAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQGIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADMDFSALLSQISS,negative +AGUAAUACGACUCACUAUAGGGAGAAUUCCGACCAGAAGGGUUAGCGGUCGUCUUAAGUAGUUUUUGGUCCUUUCCUCUCUCCUUCCUCUUCU,MSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA,negative +GGACAANNAGCGGUGUCUUUUCAUUUNNAUCCUCCGACNUCC,MDKLVVNYYEYKHPIINKDLAIGAHGGKKFPTLGAWYDVINEYEFQTRCPIILKNSHRNKHFTFACHLKNCPFKVLLSYAGNAASSETSSPSANNNTNPPGTPDHIHHHSNNMNNEDNDNNNGSNNKVSNDSKLDFVTDDLEYHLANTHPDDTNDKVESRSNEVNGNNDDDADANNIFKQQGVTIKNDTEDDSINKASIDRGLDDESGPTHGNDSGNHRHNEEDDVHTQMTKNYSDVVNDEDINVAIANAVANVDSQSNNKHDGKDDDATNNNDGQDNNTNNDHNNNSNINNNNVGSHGISSHSPSSIRDTSMNLDVFNSATDDIPGPFVVTKIEPYHSHPLEDNLSLGKFILTKIPKILQNDLKFDQILESSYNNSNHTVSKFKVSHYVEESGLLDILMQRYGLTAEDFEKRLLSQIARRITTYKARFVLKKKKMGEYNDLQPSSSSNNNNNNDGELSGTNLRSNSIDYAKHQEISSAGTSSNTTKNVNNNKNDSNDDNNGNNNNDASNLMESVLDKTSSHRYQPKKMPSVNKWSKPDQITHSDVSMVGLDESNDGGNENVHPTLAEVDAQEARETAQLAIDKINSYKRSIDDKNGDGHNNSSRNVVDENLINDMDSEDAHKSKRQHLSDITLEERNEDDKLPHEVAEQLRLLSSHLKEVENLHQNNDDDVDDVMVDVDVESQYNKNTTHHNNHHSQPHHDEEDVAGLIGKADDEEDLSDENIQPELRGQ,negative +AGUCAUUUAUAAGAUCCGACAACCUGUCUAUUAGUUGCGCCGAUUAAGUGACU,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +UGGGGUAUCGCCAAAAGAAAGGCACCGGAUUCUGAUUCCGGAGGUCGAGAUUGUCGUCCUCGUACCCCAGCCA,MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP,negative +CAUACCAUCCCCAUUUUCGCAAUGAAAAG,MVKSHIGSWILVLFVAMWSDVGLCKKRPKPGGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGSHSQWNKPSKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGNDYEDRYYRENMYRYPNQVYYRPVDRYSNQNNFVHDCVNITVKQHTVTTTTKGENFTETDIKIMERVVEQMCITQYQRESQAYYQRGASVILFSSPPVILLISFLIFLIVG,negative +CTTCTGCCCGCCTCCTTCCGACGGTGATTGTTATCTCAGAGCCAGTTTGAACAACCCGGGAGACGAGATAGGCGGACACT,MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA,negative +TATGGGAGCATATACTATTCTATGATATTTCTATGCAATTCAAGAGTCTA,IMEIRTVAVGIVAIKGVESEYYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHSGGEMFVALNQKGLPVKGKKTKKEQKTAHFLPMAIT,negative +GGTTGGTCTGGTTGG,XQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGSTGSPGPGYGYSNYGFPPYGGITFHPGVTKSNAGVTHGTINTKFKNGPKDCAKSDDEESLTLPEKETEGEGPSLPMACTKTEPIALASTMEDKEQDMGFQDNLFLEKALQLARRHANALFDYAVTGDVKMLLAVQRHLTAVQDENGDSVLHLAIIHLHAQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRVGADLSLLDRWGNSVLHLAAKEGHDRILSILLKSRKAAPLIDHPNGEGLNAIHIAVMSNSLPCLLLLVAAGAEVNAQEQKSGRTALHLAVEYDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWEKAGEDEGVVPGTTPLDMAANWQVFDILNGKPYEPVFTSDDILPQGDMKQLTEDTRLQLCKLLEIPDPDKNWATLAQKLGLGILNNAFRLSPAPSKTLMDNYEMNSGIVTASVTVVWRHPSANSALQSLLLETAHCYL,negative +ATCAGGGCTAAAGAGTGCAGAGTTACTTAG,PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGKISKIGPENPYNTPVFAIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDESFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPXRXKNPEMVIYQYMDDLYVGSDLEIGQHRAKIEELRSHLLSWGFTTPDKKHQKEPPFLWMGYELHPDSWTVQPIELPEKDSWTVNE,negative +TCCCACGCATTCTCCACATCGAGGAGTATCGGGGCACGATCCTATTTAAGGCCGATAACCCCTTTCTGTCCTTCCGTCAC,MSMSPKHTTPFSVSDILSPLEESYKKVGMEGGGLGAPLAAYRQGQAAPPAAAMQQHAVGHHGAVTAAYHMTAAGVPQLSHSAVGGYCNGNLGNMSELPPYQDTMRNSASGPGWYGANPDPRFPAISRFMGPASGMNMSGMGGLGSLGDVSKNMAPLPSAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGGGGGGGAGCPQQQQAQQQSPRRVAVPVLVKDGKPCQAGAPAPGAGSLQGHAQQQAQQQAQAAQAAAAAISVGSGGPGLGAHPGHQPGSAGQSPDLAHHAASPAALQGQVSSLSHLNSSGSDYGTMSCSTLLYGRTW,negative +AAGACGGCCGGCGCCAUAGCCGAGAUCCGAGGUGUUGA,MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINYDEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQAVAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQGIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADMDFSALLSQISS,negative +TTAGCAAAGTTGAAGCCGGACTAACAAGCTCTACG,DHNPPTIELIQRFCSDVDMWLKEDSSNVVAVHCKAGKGRTGTMICAYLVFSGIKKSADEALAWYDEKRTKDRKGVTIPSQRRYVQYFSKLVCSSVPYSKVSLNVCEIRFSESSCVQNLGMVECSISVLHDSATENAKPDRLKTLPIDFQKSFVLTIKPSIPVSGDVKFELTKKSPDKIICHFWLNTFFVRNYSPCESDGTVNKYIHTLSKSEIDDVHKDSEHKRFSEEFKISIVFEAENFSNDVQAEASEKERNENVLNFERSDYDSLSPNCYAEKKVLTAIVNDNTTKSQTIETLDHKDIVTKIQYDTSTNSKNTSTACKRKQPNSKTLLPSLNDSTKEEIKRNHIFNQPSIKKTDLIKWQNSEVHITRSINENKNINYNSYITCKQSSPKFNCGTEDGEEDWESGESTYL,negative +GUAUAUGUAUGUGUUGUUUUAUUGUGUGUGUGUGU,MAKGEFIRTKPHVNVGTIGHVDHGKTTLTAALTYVAAAENPNVEVKDYGDIDKAPEERARGITINTAHVEYETAKRHYSHVDCPGHADYIKNMITGAAQMDGAILVVSAADGPMPQTREHILLARQVGVPYIVVFMNKVDMVDDPELLDLVEMEVRDLLNQYEFPGDEVPVIRGSALLALEEMHKNPKTKRGENEWVDKIWELLDAIDEYIPTPVRDVDKPFLMPVEDVFTITGRGTVATGRIERGKVKVGDEVEIVGLAPETRKTVVTGVEMHRKTLQEGIAGDNVGLLLRGVSREEVERGQVLAKPGSITPHTKFEASVYILKKEEGGRHTGFFTGYRPQFYFRTTDVTGVVRLPQGVEMVMPGDNVTFTVELIKPVALEEGLRFAIREGGRTVGAGVVTKILE,negative +TTGCACAAGATACGGCTACCTGTATGCGGCAATCGGCATTAAATCTATCTAAGCCAGCAGTAAC,MAAKVASTSSEEAEGSLVTEGEMGEKALPVVYKRYICSFADCGAAYNKNWKLQAHLCKHTGEKPFPCKEEGCEKGFTSLHHLTRHSLTHTGEKNFTCDSDGCDLRFTTKANMKKHFNRFHNIKICVYVCHFENCGKAFKKHNQLKVHQFSHTQQLPYECPHEGCDKRFSLPSRLKRHEKVHAGYPCKKDDSCSFVGKTWTLYLKHVAECHQDLAVCDVCNRKFRHKDYLRDHQKTHEKERTVYLCPRDGCDRSYTTAFNLRSHIQSFHEEQRPFVCEHAGCGKCFAMKKSLERHSVVHDPEKRKLKEKCPRPKRSLASRLTGYIPPKSKEKNASVSGTEKTDSLVKNKPSGTETNGSLVLDKLTIQ,negative +GCGAGCAUCAGCCGC,AKTALQVPLPHPMQMNALGGYSPASTCNGYGRMGLHQEKLPSDLDGMFIERLDCDMESIIRNDLMDGDTLDFNFDNVLPNQSFPHSVKTTTHSWVSG,negative +GGAGUCUUAGGCAGCGCGUUUUCGAGCUACUCCA,MLNQLDNLTERVRGSNKLVDRWLHVRKHLLVAYYNLVGIKPGKESYMRLNEKALDDFCQSLVDYLSAGHFSIYERILHKLEGNGQLARAAKIWPQLEANTQQIMDYYDSSLETAIDHDNYLEFQQVLSDIGEALEARFVLEDKLILLVLDAARVKHPA,negative +GGGAGAAUUCAACUGCCAUCUAUAGAAGAUGAUGCCUGGAUACAAUACAGCCACUCCUCGACUGUAAACCGAGUCCAGAAGCUUGUAGU,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,negative +AGCGCGCACCTACTGTGATGAAGAAGTCACAGCAAGGCCC,MSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEMLDRHHTHFCPLEGESWQDFLRNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAFLCQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERETPTTDSMPPLLRQAIELFDHQGAEPAFLFGLELIICGLEKQLKCESGS,negative +AATACCCCCCCTTCGGTGCCTCTTCAGTTAAAAATAACTGAAGAGGCACCGAAGGGGGGG,MKKTLIALAIAASAASGMAHAWMTGDFNGSVDIGGSITADDYRQKWEWKVGTGLNGFGNVLNDLTNGGTKLTITVTGNKPILLGRTKEAFATPVTGGVDGIPHIAFTDYEGASVVLRNPDGETNKKGLAYFVLPMKNAEGTKVGSVKVNASYAGVLGRGGVTSADGELLSLFADGLSSIFYGGLPRGSELSAGSAAAARTKLFGSLSRNDILGQIQRVNANITSLVDVAGSYRENMEYTDGTVVSAAYALGIANGQTIEATFNQAVTTSTQWSAPLNVAITYY,negative +GGGAACUCGAUGAAGCGAAUUCUGUUGGCGAACUGUACGCAAGUACACUGGAUGACAGGCCUAUCUAUCGGAUCCACG,MLSWGYFLFLLPTLPGAQSQVQLVESGGDVRKPGDSLRLSCKGSGFTFSNYWLGWVRQAPGKALNGSLPLTPLAAAPTYIPGVSGRFTISRDNARALLHLDMSDLRPEDTGRYHCER,negative +GGGAGAGCGAAGCGUGCUGGGCUGCUAUUUUGGCGUAAGCUGGUUUUUGGUGGUUGCGUUUUGAUCAUAACCCAGAGGUCGAUGGAUCC,MSSSQKKAGGKAGKPTKRSQNYAALRKAQLPKPPALKVPVVKPTNTILPQTGCVWQSLGTPLSLSSFNGLGARFLYSFLKDFVGPRILEEDLIYRMVFSITPSHAGTFCLTDDVTTEDGRAVAHGNPMQEFPHGAFHANEKFGFELVFTAPTHAGMQNQNFKHSYAVALCLDFDAQPEGSKNPSFRFNEVWVERKAFPRAGPLRSLITVGLFDEADDLDRH,negative +CAGCGAAAGUUGCGUAUGGGUCACAUCGCAGGCACAUGUCAUCUGGGCG,MNRNCASPEEGGTTEQLVKEASDIVERDGFENKKKPPTLKLEHVEVVGEKSPTPATVYDLFKKYKKPDIVTNSNGDDMNVGFDQLSSDEKNGFLRKLQMLTVSSRKSVKVVGESTPSSAGRLLKKFAPSRKPTEKISVDEPPSRFNFFGRSTKKLSDSDRPSSLPKKKSARRLLFGKEEQKPEPEVVKNRVLPAMTSQQSAKGAPIPINKPYRYQGPRGSLETPTDSPAKISSNSSSSSPIPPVPTRNHFTSMNEESPSKKRTFSRQGLSNRDNLSNGSWHGELPPRDYTSPTFSRKIFVGGVPWDITEAALKDSFGEFGSCAVEWPGQEARYRSGQSNIAPLTNLRNQSKYAGQAATGYVYMIFEDERAVASLLHECSQEIGGAGEWYFKIRAQRSKSTEIRQVQIIPWVTSDSMFCEDESLLETGIEPKRTVFVGALHGMMTAQVLHWIMEDCFGSVECVQLDTDKFKYPIGSGRVTFREHGAYFKAIEMGYLHVHTSKFRKRVQIDPFLESTSCMVCTTESAQCFCRNRNCFKYYCHTCWAIDHGKDNADDVHVPVIVPSSASKAYAGPHRRPHLTSNSLSKSHGCSTNNQLSHVLSPGFPMIVGGPSQTLSALYGYIQNNQQMMLTPAVYETPMTPPSNESNAKRRSFTEFQNPAIFFNPSSMMTPQKSATCSETPVPAFFTNSAAFLTPNSNYYGSPNHSSSNISQSPQQYYGANLYYGYMPPQVAYDGSTNGSKLSPIHVPHIPNYQ,negative +ACAAGAAGGACAGCACGAAUAAAACCUGCGUAAAUCCGCCCCAUUUGUGUAAGGGUAGUGGG,MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC,negative +GACAUCUGUAAGUAAGAUUCUAUCUGCAAAGCGGUUAGGAGGGCUCGGACUCUGAUUGCCUCCCCGCACC,MRKIVVAAIAVSLTTVSITASASADPSKDSKAQVSAAEAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKVKPSAASIDAAKKAGVNNGNPLDAVQQ,negative +AUAGCCUCCGAUCCGCUAACUCUAACCCGCCAACUCCU,MAWYWWRRRRRRGWWKPRRRRWRRRRARRRGPARRHRARRRIVRHPCNGQTSSGNRVPRSVQAVDPKYVSLQLVWHSWDFRRGLFGQAGIKRMQQESDALTLSPVHRPKRPKRDTQVKEKTPEKDSDSAVQLRRLQPWIHSSQETKDEEEEIPEGPVQEQLLQQLQQQRLLRVQLESIAQEVLKIRRGHSLHPLLSSHA,negative +GGGCGAAUUCAACUGCCAUCUAGGCAGUAACCAGGAGUUAGUAGGACAAGUUUCGUCC,MVKSHIGSWILVLFVAMWSDVGLCKKRPKPGGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGSHSQWNKPSKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGNDYEDRYYRENMYRYPNQVYYRPVDRYSNQNNFVHDCVNITVKQHTVTTTTKGENFTETDIKIMERVVEQMCITQYQRESQAYYQRGASVILFSSPPVILLISFLIFLIVG,negative +CCCTTCATCATTAACCCGTCCACGCGC,MPEEWVRIFGEAGITQFEQQRNPRLCLSVLNILSKSEHPQEKFMFVPYEQSALPVTDNSPFGDTSITHNYADHHFKASTPENEGSSFYSRVPGPCTVGVRSSSLSSGRGSSEGVGSRSGSGSGGAASRSSSSGHGGAGFPLPVTSVPANGRSSAPGPNSMTVTSGSHSSSGSNCSTGSLTGGMELTNTMVATTQRTGPNNVLVNGHSTGNHFHGGVTQRVAASAAPTECNVLPTYTGSSSSYQPTSFQSMAVHTPPAYTLRQIPPAHSIGYPYTSTAPTSESIILTAPTTTPSSTVYHTTQGSAIVKPLSDNQSQRDKLPYLMHKSQWHSNVTGHVPLSPGLPRRFVDGVLPPETSAHIQYSSGQSSPSPAGSATPVPTPRRESLAGSVPVRAGPAPPALATHELSSDANCTLTPPPVATRPEKTKSIYTKPVEAQCDGHLTIGDQQDASRRSLETPVPPQTAATIHGSENETRTNVTVLPTVHSDGNNSSVHAYQQATESRPLKPNTLERQGQKKVRPKISDEAIQEKLRMIVSIGDPNRKYQRQEKIGQGASGTVYGGIEVATGRRVAIKQMNLKQQPKKELIVNEIYVMKAKKHPNVVNYLDSYLVADELWVVMEYLDGGSLTEVVTETYMEEGQIAAVCRECLQALDFLHKNQVIHRDIKSDNILLGLDGSVKLTDFGFCAQLSSEQNKRSTMVGTPYWMAPEVVTRKQYGPKVDIWSLGIMAIEMLDGEPPYLNENPVRALYLIGTNGKPEIKERDKLSSEFQDFLDLCLEVKVERRATAQELLQHIFSRDGHRAMELLQTDNFHSSGVRKKRTPRLAIEKLVDPEVKRNYQNQLVECLPDGTVSDINGHWEKISKALLKPRRTVVMAAGEDELVVTVRGTSFNCPPTSLVEPNTGIIAPLIEPHHRGIGSYALEVVADIIGTLDYCGIAFLTMGSFVPYLYYSFYCVLWLKLFYLALIFALGSGAIAVSMSNTFASPAYRPLRALVFIALGLSGVIPCVHVTITNGFWPSLQHGSLGWLFLMAVLYITGASIYAVRVPERIFPGRFDIWFQSHQIFHVFVVAAALVHYHGIIGLTNYRLAIGDCRPPPGYPFPKHDYDNIELLRPFMTY,negative +GCUAGGCAAUGAAACGGUUGGAGUAAUCCGGUGGCUUGCCAUGAUUUACGUGAGUGCUGAUCCGUGAUG,IMEIRTVAVGIVAIKGVESEYYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHSGGEMFVALNQKGLPVKGKKTKKEQKTAHFLPMAIT,negative +AGCAGCACAGAGGTCAGATGCGCGCAGAATTTTGAGTCATGTACTAAGGAATTGATTGGTCCTATGCGTGCTACCGTGAA,MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPGPHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR,negative +GAAGCUUACAAGAAGGACAGCACGAAUAAAACCUGCGUAAAUCCGCCCCAUUUGUGUAAAAAAAAAAAAAAAAAAAAAAAAA,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +AAAAAAAAAAAAAAA,MGVHECPAWLWLLLSLLSLPLGLPVLGAPPRLICDSRVLERYLLEAKEAENITTGCAEHCSLNENITVPDTKVNFYAWKRMEVGQQAVEVWQGLALLSEAVLRGQALLVNSSQPWEPLQLHVDKAVSGLRSLTTLLRALGAQKEAISPPDAASAAPLRTITADTFRKLFRVYSNFLRGKLKLYTGEACRTGDR,negative +UCACCCUGAACCGGCCCAGCAGACUGCUGACGGCACGAU,LQENFLPQPRQQHHGTLVLHYRPHREEAGMQHPCLWPGSSHCSDDSTLRRLQCESVTSIGAVCP,negative +AAGACTAGAAGAAGTATTAAGCCTGTATTACAGAAGAGGT,MAAGTAVGAWVLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISIIEPGEEGPTAGSVGGSGLGTLALALGILGGLGTAALLIGVILWQRRQRRGEERKAPENQEEEEERAELNQSEEPEAGESSTGGP,negative +AATAGCCCCCCTTCGGTGCAAAGCACCGAAGGGGGGC,MNIKAILSLCLFLILQCVRARVFVSRLEAASLLARSRRANSPFSMEETKQGSLERECREETCNFEEAREIFEDDQRTNAFWTLYIRPNPCLSNPCQNGGTCQHTHTVYMCVCPRGWEGRVCSQEVSTGQSCKVNNGRCDHYCEEEEAAAGGRRGAVCSCAPGYHLARNRRSCMAMEAFPCGRVASPKSDILMGNSSEAATDVPTPTSQAANVNSSSIIGDDSEPQASFGHSNHRGRVVGGKECPRGQCPWQVLISRKGAPVCGGTILSPQWILTAAHCTIYETKNLRILAGEHNVDEVEGSEQELGILRIVDHPSFNIKLSYDNDISLIQLSRPIQFTRYALPICLPNQRFVRGVLRSVVAGTVSGWGKLNEFGPAAGILQRLEVPYVDDEQCRAAMGSKVITANMFCAGYETGGQDSCSGDSGGPHATRYGSTWFLTGVVSWGKGCAREGKFGVYTKVLNYLDWIAQTMAETESHALPEPAQH,negative +CTTCTGCCCGCCTCCTTCCGAGCATTCGTCAGATAGGTGGCAAACAGTTATGGGAACGGGAGACGAGATAGGCGGACACT,MAGRSGDSDEELLKAVRLIKFLYQSNPPPNPEGTRQARRNRRRRWRERQRQIHSISERILSTYLGRSAEPVPLQLPPLERLTLDCNEDCGTSGTQGVGSPQILVESPTILESGAKE,negative +TTAGCAAAGTTGAAGCCGGACTAACAAGCTCTACG,MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH,negative +ACAGCGCCGGUGGGCGGGCAUUGGGUGGAUGCGCUGU,MACAAARSPADQDRFICIYPAYLNNKKTIAEGRRIPISKAVENPTATEIQDVCSAVGLNVFLEKNKMYSREWNRDVQYRGRVRVQLKQEDGSLCLVQFPSRKSVMLYAAEMIPKLKTRTQKTGGADQSLQQGEGSKKGKGKKKK,negative +TGCAGATGCAAGGTAACCATATCCAAAGCA,AKTALQVPLPHPMQMNALGGYSPASTCNGYGRMGLHQEKLPSDLDGMFIERLDCDMESIIRNDLMDGDTLDFNFDNVLPNQSFPHSVKTTTHSWVSG,negative +TCTCATGCGTCGAGTGTGAGTTTAACTGCGT,MAKGEFIRTKPHVNVGTIGHVDHGKTTLTAALTYVAAAENPNVEVKDYGDIDKAPEERARGITINTAHVEYETAKRHYSHVDCPGHADYIKNMITGAAQMDGAILVVSAADGPMPQTREHILLARQVGVPYIVVFMNKVDMVDDPELLDLVEMEVRDLLNQYEFPGDEVPVIRGSALLALEEMHKNPKTKRGENEWVDKIWELLDAIDEYIPTPVRDVDKPFLMPVEDVFTITGRGTVATGRIERGKVKVGDEVEIVGLAPETRKTVVTGVEMHRKTLQEGIAGDNVGLLLRGVSREEVERGQVLAKPGSITPHTKFEASVYILKKEEGGRHTGFFTGYRPQFYFRTTDVTGVVRLPQGVEMVMPGDNVTFTVELIKPVALEEGLRFAIREGGRTVGAGVVTKILE,negative +GGCAGCGAAAGCGGAACAAGUAUGUAACCAUGCCUCGGCAACUUUACAUGCGUAGCCAAACCCA,SESGFNLSCQCLGFGSGHFKCDSSKWCHDNGVNYKIGEKWDRQGENGQMMSCTCLGNGKGEF,negative +TCAAACGTTGGATTAAGGTCAAATGAGTCGTTTTTC,MGVHECPAWLWLLLSLLSLPLGLPVLGAPPRLICDSRVLERYLLEAKEAENITTGCAEHCSLNENITVPDTKVNFYAWKRMEVGQQAVEVWQGLALLSEAVLRGQALLVNSSQPWEPLQLHVDKAVSGLRSLTTLLRALGAQKEAISPPDAASAAPLRTITADTFRKLFRVYSNFLRGKLKLYTGEACRTGDR,negative +ACTACACGAGGACCTACGACTACTACATTATGCCAACCGGTCTTGCTTCGACACAGATACCTC,MPSNQEARLFLAVLVLAQVLPILVDSAAEKGFKQAFWQPLCQVSEELDDQPKGALFTLQAAASKIQKMRDAALRASIYAEINHGTNRAKAAVIVANHYAMKADSGLEALKQTLSSQEVTATATASYLKGRIDEYLNLLLQTKESGTSGCMMDTSGTNTVTKAGGTIGGVPCKLQLSPIQPKRPAATYLGKAGYVGLTRQADAANNFHDNDAECRLASGHNTNGLGKSGQLSAAVTMAAGYVTVANSQTAVTVQALDALQEASGAAHQPWIDAWKAKKALTGAETAEFRNETAGIAGKTGVTKLVEEALLKKKDSEASEIQTELKKYFSGHENEQWTAIEKLISEQPVAQNLVGDNQPTKLGELEGNAKLTTILAYYRMETAGKFEVLTQKHKPAESQQQAAETEGSCNKKDQNECKSPCKWHNDAENKKCTLDKEEAKKVADETAKDGKTGNTNTTGSSNSFVISKTPLWLAVLLF,negative +ACCAAAATCAACGCAAAGAGCGCGCCTGCACGTCACCTCA,MEPVDPRLEPWKHPGSQPKTACTNCYCKKCCFHCQVCFITKALGISYGRKKRRQRRRAHQNSQTHQASLSKQPTSQPRGDPTGPKE,negative +GCATCAAGACCCTGCGCATGGAGCCTTCTGCAACCACTCC,MACAAARSPADQDRFICIYPAYLNNKKTIAEGRRIPISKAVENPTATEIQDVCSAVGLNVFLEKNKMYSREWNRDVQYRGRVRVQLKQEDGSLCLVQFPSRKSVMLYAAEMIPKLKTRTQKTGGADQSLQQGEGSKKGKGKKKK,negative +GGGCGAAUUCGAGCCUCAAGACGUCGGGGAUUGGCAAACCCCGUUUCCUUGAGCGACCCCCUGUUACUCGGCGGAUCCUCU,MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYTFLLPEMDNCRSSSSPYVSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQDNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVLVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF,negative +CTCCTCTGACTGTAACCACGCCGAAGACCTTTTTAGCGTACTGAAAAGGAGTTACTCTCGCATAGGTAGTCCAGAAGCC,MSKRKAPQETLNGGITDMLVELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVTGIGPSAARKLVDEGIKTLEDLRKNEDKLNHHQRIGLKYFEDFEKRIPREEMLQMQDIVLNEVKKLDPEYIATVCGSFRRGAESSGDMDVLLTHPNFTSESSKQPKLLHRVVEQLQKVRFITDTLSKGETKFMGVCQLPSENDENEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEQDIFDYIQWRYREPKDRSE,negative +GACCGGUGUGUCCUGAUCCAACUGCCACAAGUACCAUAUGCAGGUGACGU,MSSTESPVPAAAAPAEAVPASTPAPAAEQPAVGNGEQRNNADAANNTSLYVGELDPSVTEAMLFEIFSMIGTVASIRVCRDAVTRRSLGYAYVNFLNAADGERAMEQLNYSLIRNRPCRIMWSQRDPALRRTGQGNIFIKNLDAGIDNKALHDTFAAFGNILSCKVATNETGSLGYGFVHYETAEAAEAAIKHVNGMLLNDKKVYVGHHIPRKERQAKIEETRANFTNVYAKNVDPEVTDDEFEKLFTKFGKITSCVLQRDEDGKSKGFGFVNFEDHNEAQKAVDELHDSDFKGQKLFVARAQKKSEREEELRRSYEAAKNEKLAKFQGVNLYLKNIPESYDDERLREEFAPFGAITSCKIMRAPSGVSRGFGFVCYSAPEEANKAVSEMNGKMLDNRPLYVALAQRKDVRRQQLEAQIMQRNQLRLQQQAAAQGMGYPGPGMYYPQPGAFPGQPGGMVPRPRYAPAGMMPQGMPMAPYGQPGQFPAGMMPQGYRPARPPRGAPNAAGGPAPPAGARPPTGVNGAPRPAGQPVPGQPMPRGPAARPAGRPEADQPGALTAAALAKASPEEQKQMLGEAIYPKVAASQPELAGKLTGMILELPVTELLHLLEESEALDAKVNEALEVLKEYQQNDSAGAEAEANAEAPKTEA,negative +CTTCTGCCCGCCTCCTTCCGATTGAAAGGTCTGTTTTTGGGGTTGGTTTGGGTCAATAGGAGACGAGATAGGCGGACACT,MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC,negative +AAGGACAGCACGAAUAAAACCUGCGUAAAUCCGCCCCAUUUGUGUAAGGGUAGUGGG,QDRPIKFSTEGATSQSYKQFIEALRERLRGGLIHDIPVLPDPTTLQERNRYITVELSNSDTESIEVGIDVTNAYVVAYRAGTQSYFLRDAPSSASDYLFTGTDQHSLPFYGTYGDLERWAHQSRQQIPLGLQALTHGISFFRSGGNDNEEKARTLIVIIQMVAEAARFRYISNRVRVSIQTGTAFQPDAAMISLENNWDNLSRGVQESVQDTFPNQVTLTNIRNEPVIVDSLSHPTVAVLALMLFVCNPPNANQSPLLIRSIVEKSKICSSRYEPTVRIGGRDGMCVDVYDNGYHNGNRIIMWKCKDRLEENQLWTLKSDKTIRSNGKCLTTYGYAPGSYVMIYDCTSAVAEATYWEIWDNGTIINPKSALVLSAESSSMGGTLTVQTNEYLMRQGWRTGNNTSPFVTSISGYSDLCMQAQGSNVWMADCDSNKKEQQWALYTDGSIRSVQNTNNCLTSKDHKQGSTILLMGCSNGWASQRWVFKNDGSIYSLYDDMVMDVKGSDPSLKQIILWPYTGKPNQIWLTLF,negative +CTTGGATCACCATAGTCGCTAGTCGAGGCT,MASTSRLDALPRVTCPNHPDAILVEDYRAGDMICPECDRVIDVGSEWRTFSNDKATKDPSRVGDSQNPLLSDGDLSTMIGKGTGAASFDEFGNSKYQNRRTMSSSDRAMMNAFKEITTMADRINLPRNIVDRTNNLFKQVYEQKSLKGRANDAIASACLYIACRQEGVPRTFKEICAVSRISKKEIGRCFKLILKALETSVDLITTGDFMSRFCSNLCLPKQVQMAATHIA,negative +GGCAGCGAAAGCAGAAGAAGUAUGUGACCAUGCUUCGGCAACUUCACAUGCGUAGCCAAACCGA,MKPGGNTIVIWMYAVATWLCFGSTSGWSFTLEDNNIFPKQYPIINFTTAGATVQSYTNFIRAVRGRLTTGADVRHEIPVLPNRVGLPINQRFILVELSNHAELSVTLALDVTNAYVVGYRAGNSAYFFHPDNQEDAEAITHLFTDVQNRYTFAFGGNYDRLEQLAGNLRENIELGNGPLEEAISALYYYSTGGTQLPTLARSFIICIQMISEAARFQYIEGEMRTRIRYNRRSAPDPSVITLENSWGRLSTAIQESNQGAFASPIQLQRRNGSKFSVYDVSILIPIIALMVYRCAPPPSSQFSLLIRPVVPNFNADVCMDPEPIVRIVGRNGLCVDVRDGRFHNGNAIQLWPCKSNTDANQLWTLKRDNTIRSNGKCLTTYGYSPGVYVMIYDCNTAATDATRWQIWDNGTIINPRSSLVLAATSGNSGTTLTVQTNIYAVSQGWLPTNNTQPFVTTIVGLYGLCLQANSGQVWIEDCSSEKAEQQWALYADGSIRPQQNRDNCLTSDSNIRETVVKILSCGPASSGQRWMFKNDGTILNLYSGLVLDVRASDPSLKQIILYPLHGDPNQIWLPLF,negative +ATCAACTCACCGTAGGTCTAGTGAGAACTTCAAGTCTACT,VENLMVQELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFSHFRLFDENNDAAILILLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVN,negative +UGACGCGAUCCGCCGUUCCCAUCCGCACGCCCUACACCU,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,negative +AUCGCAUCUGAACCGGCCCAGCAGACUGCUGACGGCACGAU,MANLGYWLLALFVTMWTDVGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGTWGQPHGGGWGQPHGGSWGQPHGGSWGQPHGGGWGQGGGTHNQWNKPSKPKTNLKHVAGAAAAGAVVGGLGGYMLGSAMSRPMIHFGNDWEDRYYRENMYRYPNQVYYRPVDQYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCVTQYQKESQAYYDGRRSSSTVLFSSPPVILLISFLIFLIVG,negative +GGGAGAAGGGAAGTAACAGGAGCAUUAGCUACCAAGGGGUCGGGUUGUGGGUGAGAAGAGGTGACGGTACCAG,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +GGACCUUUGUACCCCAGAUGAUAGUGAGGCGCGGCUUGAUGGGUACAAAUGGCAG,MAWYWWRRRRRRGWWKPRRRRWRRRRARRRGPARRHRARRRIVRHPCNGQTSSGNRVPRSVQAVDPKYVSLQLVWHSWDFRRGLFGQAGIKRMQQESDALTLSPVHRPKRPKRDTQVKEKTPEKDSDSAVQLRRLQPWIHSSQETKDEEEEIPEGPVQEQLLQQLQQQRLLRVQLESIAQEVLKIRRGHSLHPLLSSHA,negative +GCCUACGGCCACACCACCCUGAAAGUGCCUGAUCUCGUCUGAUCUCAGAAGCGAUACAGGGUCGGGCCUGGUUAGUACCUGGAUGGGAGACCGCCUGGGAAUACCAGGUGUCGUAGGCUUU,PHITDVVLDKANKTPLRQLDPSRLPDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFAKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRQSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPINRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDTASEATRPATLNRFSALQQTLPAENTDNRRVVQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRTRTPATKRSFSKEVEERSRERPSQPEGLRKAASLTEDRGRDPVKREATLPPVSPPKAALSVDEVEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRLGIESTLERSTIAREHMGRLLHQLLCAGHLSTAQYYQGLYETLELAEDMEIDIPHVWLYLAELITPILQEDGVPMGELFREITKPLRPMGKATSLLLEILGLLCKSMGPKKVGMLWREAGLSWREFLAEGQDVGSFVAEKKVEYTLGEESEAPGQRTLAFEELRRQLEKLLKDGGSNQRVFDWIDANLNEQQIASNTLVRALMTTVCYSAIIFETPLRVDVQVLKVRARLLQKYLCDEQKELQALYALQALVVTLEQPANLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFNWLREAEDEESDHN,negative +CCCAGCGGACGCCTCATGCCGAGTAGCC,MSPQRDRINAFYKDNPHPKGSRIVINREHLMIDRPYVLLAVLFVMFLSLIGLLAIAGIRLHRAAIYTAEIHKSLSTNLDVTNSIEHQVKDVLTPLFKIIGDEVGLRTPQRFTDLVKFISDKIKFLNPDREYDFRDLTWCINPPERIKLDYDQYCADVAAEELMNALVNSTLLEARATNQFLAVSKGNCSGPTTIRGQFSNMSLSLLDLYLSRGYNVSSIVTMTSQGMYGGTYLVEKPNLSSKGSELSQLSMHRVFEVGVIRNPGLGAPVFHMTNYFEQPVSNDFSNCMVALGELKFAALCHREDSITIPYQGSGKDVSFQLVKLGVWKSPTDMQSWVPLSTDDPVIDRLYLSSHRGVIADNQAKWAVPTTRTDDKLRMETCFQQACKGKIQALCENPDWAPLKDNRIPSYGVLSVNLSLTVELKIKIASGFGPLITHGSGMDLYKSNHNNMYWLTIPPMKNLALGVINTLEWIPRFRVSPNLFTVPIKEAGEDCHAPTYLPAEVDGDVKLSSNLVILPGQDLQYVLATYDTSRVEHAVVYYVYSPSRSFSYFYPFRLPIKGVPIELQVECFTWDQKLWCRHFCVLADSGSGGHITHSGMVGMGVSCTVTREDGTNRR,negative +GGUUGGGUUGUCGUAGAUAGAGCGCUUCAA,MANLGYWLLALFVTMWTDVGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGTWGQPHGGGWGQPHGGSWGQPHGGSWGQPHGGGWGQGGGTHNQWNKPSKPKTNLKHVAGAAAAGAVVGGLGGYMLGSAMSRPMIHFGNDWEDRYYRENMYRYPNQVYYRPVDQYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCVTQYQKESQAYYDGRRSSSTVLFSSPPVILLISFLIFLIVG,negative +TAATACGACTCACTATAGGGAGACCCAAGCCGATTTATTTTGTGCAGCTTTTGTTCCCTTTAGTGAGGGTTAATT,MDSTNYISKLFEYAQRQGQISDIKFEEVGTDGPDHLKTFTLRVVIKGHAYPNGVGKTKKEAKRNAAKHALIGMMETTEQKDASVSCPPSPAPSPAPPVRAVISQPKYVSWLNEHSQKNKLSLKALEGARVGPNNTSQCCRYVVGEKEYPEGFGNTKKEAKEEAAMQVYLELCGGSQTTGTVDENCNGTTGKHKEELNGKVVVLSEKVEHMNMSPAQNVPEQYSFITTEETNFIGILNHYCQKTKRFLDFKLVEKSGPSHNPQFVYKVLIDKREYPDGLGKTAKEAKQQAAQLAWSALQEQSDWNSQVSCRSTVSEEGGLSSLTPSSTWESQDATPSSLSIAGSTSESIIFSDSVNVSSPKDESPVNVKPKIRLAANFQMSPVKTKQEGPNLKGNDLGTLSSGRTSNQPVISRFSSEFDSIENIGKGGFGHVYKARRKLEQKYFAVKIVRSKGKAKREVGALADLQHPNIVRYYTAWLEDTAYRCDTASESDTTSDSGSSSSSEFLYIQMELCDKRTLKVWIDERNAHRKPKRREESLSITQQIVNGVEYIHSKKLLHRDLKPANIMFGMSDGEGKGEVKIGDFGLVTAEDNDNDENLLERTKKTGTVSYMAPEQRNQTSYDRKVDIFALGLIYFEPLWDLSGMEKAKVWNDVRSQRFPQQFNSQFTLENKVIESLLCANPEERPDARQLKTKLNECSRVLTRVHNIHQDNRTI,negative +GCAATGGTACGGTACTTCCTGTGGCGAGGTAGGTGGGGTGTGTGTGTATCCAAAAGTGCACGCTACTTTGCTAA,GLVKKAHEISVLCDAELALIIFSPKGKLYEYATDSKMEIILERYERYTYAEKALIASDPDVQGNWCHEYIKLKAKFEALNKSQRHLMGEQLDTLNQKELLQLETKLEGSLKNVRSRKTQLMLDSISELQEKGKSLQEQNTCLEKEILGKQKDKAPKQHVQWEKQNQPPPTSSAPMPFLIGDIHPTPNIRNFQGRTVADA,negative +GGGACACAAUGGACGACUCACUAUUUGUUUUCGCGCCCAGUUGCAAAAAGUGUCGUAACGGCCGACAUGAGAG,MSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEMLDRHHTHFCPLEGESWQDFLRNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAFLCQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERETPTTDSMPPLLRQAIELFDHQGAEPAFLFGLELIICGLEKQLKCESGS,negative +CUUGCCGUAGACCCAUUUUCCAAUCACAAGUCACGCGUCUCAAGCUGUUA,MSWLLFLAHRVALAALPCRRGSRGFGMFYAVRRGRKTGVFLTWNECRAQVDRFPAARFKKFATEDEAWAFVRKSASPEVSEGHENQHGQESEAKASKRLREPLDGDGHESAEPYAKHMKPSVEPAPPVSRDTFSYMGDFVVVYTDGCCSSNGRRRPRAGIGVYWGPGHPLNVGIRLPGRQTNQRAEIHAACKAIEQAKTQNINKLVLYTDSMFTINGITNWVQGWKKNGWKTSAGKEVINKEDFVALERLTQGMDIQWMHVPGHSGFIGNEEADRLAREGAKQSED,negative +CAGUCGUCAUGGUUAUAGCUGCCACAACCUCGGUCCUGUCUUCAACGGCC,MSKRKAPQETLNGGITDMLVELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVTGIGPSAARKLVDEGIKTLEDLRKNEDKLNHHQRIGLKYFEDFEKRIPREEMLQMQDIVLNEVKKLDPEYIATVCGSFRRGAESSGDMDVLLTHPNFTSESSKQPKLLHRVVEQLQKVRFITDTLSKGETKFMGVCQLPSENDENEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEQDIFDYIQWRYREPKDRSE,negative +ACUCACCAGUCACCAUCAGCUCAUGCGCCCCUCCCCCGAC,MPFVNKQFNYKDPVNGVDIAYIKIPNAGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAGHRLYGIAINPNRVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNRKTYLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLKNFTGLFEFYKLLCVRGIITSKTKSLDKGYNKALNDLCIKVNNWDLFFSPSEDNFTNDLNKGEEITSDTNIEAAEENISLDLIQQYYLTFNFDNEPENISIENLSSDIIGQLELMPNIERFPNGKKYELDKYTMFHYLRAQEFEHGKSRIALTNSVNEALLNPSRVYTFFSSDYVKKVNKATEAAMFLGWVEQLVYDFTDETSEVSTTDKIADITIIIPYIGPALNIGNMLYKDDFVGALIFSGAVILLEFIPEIAIPVLGTFALVSYIANKVLTVQTIDNALSKRNEKWDEVYKYIVTNWLAKVNTQIDLIRKKMKEALENQAEATKAIINYQYNQYTEEEKNNINFNIDDLSSKLNESINKAMININKFLNQCSVSYLMNSMIPYGVKRLEDFDASLKDALLKYIYDNRGTLIGQVDRLKDKVNNTLSTDIPFQLSKYVDNQRLLSTFTEYIKNIINTSILNLRYESNHLIDLSRYASKINIGSKVNFDPIDKNQIQLFNLESSKIEVILKNAIVYNSMYENFSTSFWIRIPKYFNSISLNNEYTIINCMENNSGWKVSLNYGEIIWTLQDTQEIKQRVVFKYSQMINISDYINRWIFVTITNNRLNNSKIYINGRLIDQKPISNLGNIHASNNIMFKLDGCRDTHRYIWIKYFNLFDKELNEKEIKDLYDNQSNSGILKDFWGDYLQYDKPYYMLNLYDPNKYVDVNNVGIRGYMYLKGPRGSVMTTNIYLNSSLYRGTKFIIKKYASGNKDNIVRNNDRVYINVVVKNKEYRLATNASQAGVEKILSALEIPDVGNLSQVVVMKSKNDQGITNKCKMNLQDNNGNDIGFIGFHQFNNIAKLVASNWYNRQIERSSRTLGCSWEFIPVDDGWGERPL,negative +GGCGATAGTTTCTATAGCAAGGTACAGCATTCTCTCTCCCTATAGAACCAATCCAGTACTAGC,MAITKINDCFELLSMVTYADKLKSLIKKEFSISFEEFAVLTYISENKEKEYYLKDIINHLNYKQPQVVKAVKILSQEDYFDKKRNEHDERTVLILVNAQQRKKIESLLSRVNKRITEANNEIEL,negative +CCACCGAUCGCAUCAGCUCAUGGCCCCUCCCGACCCGCCA,MSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEMLDRHHTHFCPLEGESWQDFLRNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAFLCQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERETPTTDSMPPLLRQAIELFDHQGAEPAFLFGLELIICGLEKQLKCESGS,negative +UCAAUCGGCGCUUUACUCUUGCGCUCACCGUGCCC,MASTSRLDALPRVTCPNHPDAILVEDYRAGDMICPECDRVIDVGSEWRTFSNDKATKDPSRVGDSQNPLLSDGDLSTMIGKGTGAASFDEFGNSKYQNRRTMSSSDRAMMNAFKEITTMADRINLPRNIVDRTNNLFKQVYEQKSLKGRANDAIASACLYIACRQEGVPRTFKEICAVSRISKKEIGRCFKLILKALETSVDLITTGDFMSRFCSNLCLPKQVQMAATHIA,negative +AAGACGGCCGGCGCCAUAGCCGAGAUCCGAGGUGUUGA,GLVKKAHEISVLCDAELALIIFSPKGKLYEYATDSKMEIILERYERYTYAEKALIASDPDVQGNWCHEYIKLKAKFEALNKSQRHLMGEQLDTLNQKELLQLETKLEGSLKNVRSRKTQLMLDSISELQEKGKSLQEQNTCLEKEILGKQKDKAPKQHVQWEKQNQPPPTSSAPMPFLIGDIHPTPNIRNFQGRTVADA,negative +GGAGUCUUAGGCAGCGCGUUUUCGAGCUACUCCA,AKVLVVLLLFAGVDAETHVTGGSAAHAASTFAGLFSPGAKQDIQLINTNGSWHINRTA,negative +GGGAAAAGAGACGGCCGGCGCCAUAGCCGAGAUCCGAGGUGUUGA,MDKLVVNYYEYKHPIINKDLAIGAHGGKKFPTLGAWYDVINEYEFQTRCPIILKNSHRNKHFTFACHLKNCPFKVLLSYAGNAASSETSSPSANNNTNPPGTPDHIHHHSNNMNNEDNDNNNGSNNKVSNDSKLDFVTDDLEYHLANTHPDDTNDKVESRSNEVNGNNDDDADANNIFKQQGVTIKNDTEDDSINKASIDRGLDDESGPTHGNDSGNHRHNEEDDVHTQMTKNYSDVVNDEDINVAIANAVANVDSQSNNKHDGKDDDATNNNDGQDNNTNNDHNNNSNINNNNVGSHGISSHSPSSIRDTSMNLDVFNSATDDIPGPFVVTKIEPYHSHPLEDNLSLGKFILTKIPKILQNDLKFDQILESSYNNSNHTVSKFKVSHYVEESGLLDILMQRYGLTAEDFEKRLLSQIARRITTYKARFVLKKKKMGEYNDLQPSSSSNNNNNNDGELSGTNLRSNSIDYAKHQEISSAGTSSNTTKNVNNNKNDSNDDNNGNNNNDASNLMESVLDKTSSHRYQPKKMPSVNKWSKPDQITHSDVSMVGLDESNDGGNENVHPTLAEVDAQEARETAQLAIDKINSYKRSIDDKNGDGHNNSSRNVVDENLINDMDSEDAHKSKRQHLSDITLEERNEDDKLPHEVAEQLRLLSSHLKEVENLHQNNDDDVDDVMVDVDVESQYNKNTTHHNNHHSQPHHDEEDVAGLIGKADDEEDLSDENIQPELRGQ,negative +UCUCUGGGCUCUUAGGAGAACGGAUAGGAGUGUGCUCGCU,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,negative +TATTAGTACTAATATTAGTACTAA,MAIPKELLVLLLGIAILSKVAECAAFGSRRGLVETVFDVTRFGARPNTPADSTRGLMMAWRSACQSPGPAKVVIPPGTYTTGETIFQGPCTSPRPITIEIQGTLLSNTDMSLYTRAAWISIEHVDGIVITGGGTLNGQGKSSWQFADKSGSTPPLPSSLVFQTVRSSSIKNLNFVDAKGVHLKITDSSDISVSNIKITAPGDSPNTDGLHISDTINVNVTDSTIGTGDDCISIGDGNSNVYISNINCGPGHGISIGSLGKRLDETDVKGVTVRNCTFRGTTNGARIKTYMGSPSLQVSGVVYEDIILDNVKNPIVIDQHYHSKNRNEPSRVKLVDIHFRNIRGTTTSKIPVLLNCSEALPCEGVELVDIDLAPVGSIGPLLPATCQNAKTILNGKNNPPAC,negative +CCGTAGGTTCGGGGTCGGAGTGGTCCGGAAGATGGCGTGG,PHITDVVLDKANKTPLRQLDPSRLPDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFAKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRQSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPINRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDTASEATRPATLNRFSALQQTLPAENTDNRRVVQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRTRTPATKRSFSKEVEERSRERPSQPEGLRKAASLTEDRGRDPVKREATLPPVSPPKAALSVDEVEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRLGIESTLERSTIAREHMGRLLHQLLCAGHLSTAQYYQGLYETLELAEDMEIDIPHVWLYLAELITPILQEDGVPMGELFREITKPLRPMGKATSLLLEILGLLCKSMGPKKVGMLWREAGLSWREFLAEGQDVGSFVAEKKVEYTLGEESEAPGQRTLAFEELRRQLEKLLKDGGSNQRVFDWIDANLNEQQIASNTLVRALMTTVCYSAIIFETPLRVDVQVLKVRARLLQKYLCDEQKELQALYALQALVVTLEQPANLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFNWLREAEDEESDHN,negative +CACCAGACCGACAUCAGCUUAUGGCCCCUCACCCACACCG,MANLGYWLLALFVTMWTDVGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGTWGQPHGGGWGQPHGGSWGQPHGGSWGQPHGGGWGQGGGTHNQWNKPSKPKTNLKHVAGAAAAGAVVGGLGGYMLGSAMSRPMIHFGNDWEDRYYRENMYRYPNQVYYRPVDQYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCVTQYQKESQAYYDGRRSSSTVLFSSPPVILLISFLIFLIVG,negative +GCGCAGAACGGTGCTGTAACGGTGTGGC,MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPGPHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR,negative +CACGGUACCACCAAGUCACACGUUGAACUCCAUGCAGCUG,MSDRKKIEIDAIDKKLLIELLKDSRISLRRLAEEMNVSPATLHNRLMRLVQEGVVKGFTALIDYSKLGYPVTSILMIKVDGKHILEFEKEVSNLDNVVAVYDVVGEYDVMLIAKFRSIEDLDTFIKSLLKNPKIERTYTSIVLNVVKEDPRIKII,negative +AGCTCAGAATGGATCCAAACGCTCATAACTCACTCCATACTCACTTGCTGATTCGCCAACAACACACCCTTAAACAGTCCCTTCGACATGAGAATTCGGCCGGATC,MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA,negative +TCCCACGCATTCTCCACATCTAGTCTGGTTACGGTCTCGATTGTCCCAAAAGGGCAGACACCTTTCTGTCCTTCCGTCAC,MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICEVEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASSIVYKKEGEQVEFSFPLAFTVEKLTGSGELWWQAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLPQALPQYAGSGNLTLALEAKTGKLHQEVNLVVMRATQLQKNLTCEVWGPTSPKLMLSLKLENKEAKVSKREKAVWVLNPEAGMWQCLLSDSGQVLLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQAERMSQIKRLLSEKKTCQCPHRFQKTCSPI,negative +CTTCTGCCCGCCTCCTTCCCGGGTCATATGGGAACGCTACAGTGTTTCACGCTGAGTTGGAGACGAGATAGGCGGACACT,MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINYDEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQAVAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQGIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADMDFSALLSQISS,negative +UCAUGGUGUCUUUCCACAGCUCUUCCCAUGAUCGCCCGG,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +UAAUACGACUCACUAUAGGGAGGACGAUGCGGACAUAGUAAUGACACGGAGGAUGGAGAAAAAACAGCCAUCUCUUGACGGUUCGGGCGAGUCGUCUG,VFTDNSSPPAVPQSFQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGFGAYMSKAHGVDPNIRTGVRTITTGSPITYSTYGKFLADGGCSGGAYDIIICDECHSTDATSILGIGTVLDQAETAGARLVVLATATPPGSVTVSHPNIEEVALSTTGEIPFYGKAIPLEVIKGGRHLIFCHSKKKCDELAAKLVALGINAVAYYRGLDVSVIPTSGDVVVVSTDALMTGFTGDFDSVIDCNTCVTQTVDFSLDPTFTIETTTLPQDAVSRTQRRGRTGRGKPGIYRFVAPGERPSGMFDSSVLCECYDAGCAWYELTPAETTVRLRAYMNTPGLPVCQDHLEFWEGVFTGLTHIDAHFLSQTKQSGENFPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPTLHGPTPLLYRLGAVQNEVT,negative +GGTTGGTATGGTTGG,SHGGLPCQNSQRGKRSFPAVEICKYKGPARIVVSLVTNEDTPRPHAHSLVGKHCKDGLCTVQVGPNDMTASFPNLGILHVTRKDVVPTLKTRILAQHRLYKDLINNSGGEGQWMEPSDQEIEKKAKEMAKDMDLSVVRLCFQTYLPDVKGHFTQPLEPVISVPVFDSKAPNATTLKICRMDKSAGCCTGGEEVYLLCDKVQKEVIQVKFFEVST,negative +GGACCUUUGUACCCCAGAUGAUGCUUUAUCAGGCGGAUGGGUACAAAUGGCAG,MLDLFADAEPWQEPLAAGAVILRRFAFNAAEQLIRDINDVASQSPFRQMVTPGGYTMSVAMTNCGHLGWTTHRQGYLYSPIDPQTNKPWPAMPQSFHNLCQRAATAAGYPDFQPDACLINRYAPGAKLSLHQDKDEPDLRAPIVSVSLGLPAIFQFGGLKRNDPLKRLLLEHGDVVVWGGESRLFYHGIQPLKAGFHPLTIDCRYNLTFRQAGKKE,negative +CGACGCACCGATCGCAGGTTCGGGA,MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA,negative +TCCCACGCATTCTCCACATCATTTGAATAGTGTGGTCACTTCCAGTCCCGCAGGGCACACCCTTTCTGTCCTTCCGTCAC,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +CTTTGGAGACAGTCCGTGGTAGGGCAGGTTGGGGTGACTTCGTGGAAGAAGCGAGACGGT,QSVEESRGGLIKPTDTLTLTCTVSGFSLSSYGEVWDRQAPGNGLEYIGAIGNSGSTYYASWAKSRSTITRNTNLNTVTLKMTSLTAADTATYFCAR,negative +UCGGAGGUGGUUCAGCUCUGCAUCGACAGUUGGC,PHITDVVLDKANKTPLRQLDPSRLPDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFAKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRQSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPINRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDTASEATRPATLNRFSALQQTLPAENTDNRRVVQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRTRTPATKRSFSKEVEERSRERPSQPEGLRKAASLTEDRGRDPVKREATLPPVSPPKAALSVDEVEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRLGIESTLERSTIAREHMGRLLHQLLCAGHLSTAQYYQGLYETLELAEDMEIDIPHVWLYLAELITPILQEDGVPMGELFREITKPLRPMGKATSLLLEILGLLCKSMGPKKVGMLWREAGLSWREFLAEGQDVGSFVAEKKVEYTLGEESEAPGQRTLAFEELRRQLEKLLKDGGSNQRVFDWIDANLNEQQIASNTLVRALMTTVCYSAIIFETPLRVDVQVLKVRARLLQKYLCDEQKELQALYALQALVVTLEQPANLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFNWLREAEDEESDHN,negative +AGGGAATCTTGCCTAGGGAGGGAGTAGCGAAAGGGCTCA,GLVKKAHEISVLCDAELALIIFSPKGKLYEYATDSKMEIILERYERYTYAEKALIASDPDVQGNWCHEYIKLKAKFEALNKSQRHLMGEQLDTLNQKELLQLETKLEGSLKNVRSRKTQLMLDSISELQEKGKSLQEQNTCLEKEILGKQKDKAPKQHVQWEKQNQPPPTSSAPMPFLIGDIHPTPNIRNFQGRTVADA,negative +UAUUAUGCCUUUAGCUAGCGCAUUCUGUGGGGUGGGUGGA,MPSNQEARLFLAVLVLAQVLPILVDSAAEKGFKQAFWQPLCQVSEELDDQPKGALFTLQAAASKIQKMRDAALRASIYAEINHGTNRAKAAVIVANHYAMKADSGLEALKQTLSSQEVTATATASYLKGRIDEYLNLLLQTKESGTSGCMMDTSGTNTVTKAGGTIGGVPCKLQLSPIQPKRPAATYLGKAGYVGLTRQADAANNFHDNDAECRLASGHNTNGLGKSGQLSAAVTMAAGYVTVANSQTAVTVQALDALQEASGAAHQPWIDAWKAKKALTGAETAEFRNETAGIAGKTGVTKLVEEALLKKKDSEASEIQTELKKYFSGHENEQWTAIEKLISEQPVAQNLVGDNQPTKLGELEGNAKLTTILAYYRMETAGKFEVLTQKHKPAESQQQAAETEGSCNKKDQNECKSPCKWHNDAENKKCTLDKEEAKKVADETAKDGKTGNTNTTGSSNSFVISKTPLWLAVLLF,negative +CTTCTGCCCGCCTCCTTCCTGGTAAAGTCATTAATAGGTGTGGGGTGCCGGGCATTTCGGAGACGAGATAGGCGGACACT,MPSNQEARLFLAVLVLAQVLPILVDSAAEKGFKQAFWQPLCQVSEELDDQPKGALFTLQAAASKIQKMRDAALRASIYAEINHGTNRAKAAVIVANHYAMKADSGLEALKQTLSSQEVTATATASYLKGRIDEYLNLLLQTKESGTSGCMMDTSGTNTVTKAGGTIGGVPCKLQLSPIQPKRPAATYLGKAGYVGLTRQADAANNFHDNDAECRLASGHNTNGLGKSGQLSAAVTMAAGYVTVANSQTAVTVQALDALQEASGAAHQPWIDAWKAKKALTGAETAEFRNETAGIAGKTGVTKLVEEALLKKKDSEASEIQTELKKYFSGHENEQWTAIEKLISEQPVAQNLVGDNQPTKLGELEGNAKLTTILAYYRMETAGKFEVLTQKHKPAESQQQAAETEGSCNKKDQNECKSPCKWHNDAENKKCTLDKEEAKKVADETAKDGKTGNTNTTGSSNSFVISKTPLWLAVLLF,negative +TCCCTACGGCGCTAACCAGTGCTAGCCACTGCGGGGTTCCCTTGTTGCCACCGTGCTACAAC,VVIRSNNFTDNAKTIIVQLNESIAINCTRPNNNTRKSIHIGPGRAFYTTGDIIGNIRQAHCNLSRTKWENTLKQIAKKLREQFGNKTIVFNH,negative +CTTCTGCCCGCCTCCTTCCAGCCGTCACAGGTCGCTCATTCATTACGGTCTGTTTGCGGGAGACGAGATAGGCGGACACT,MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP,negative +GGGAGGACGATGCGGTGACGTAAGAGTGTAATCGATGCAGCCTGGCAGACGACGAGCGGGA,IMEIRTVAVGIVAIKGVESEYYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHSGGEMFVALNQKGLPVKGKKTKKEQKTAHFLPMAIT,negative +TCCCTACGGCGCTAACTTCTGCAAGAGGCCGTCAACGGGCGAGTTAGCCACCGTGCTACAAC,MSGGDGRGHNTGAHSTSGNINGGPTGLGVGGGASDGSGWSSENNPWGGGSGSGIHWGGGSGHGNGGGNGNSGGGSGTGGNLSAVAAPVAFGFPALSTPGAGGLAVSISAGALSAAIADIMAALKGPFKFGLWGVALYGVLPSQIAKDDPNMMSKIVTSLPADDITESPVSSLPLDKATVNVNVRVVDDVKDERQNISVVSGVPMSVPVVDAKPTERPGVFTASIPGAPVLNISVNNSTPAVQTLSPGVTNNTDKDVRPAGFTQGGNTRDAVIRFPKDSGHNAVYVSVSDVLSPDQVKQRQDEENRRQQEWDATHPVEAAERNYERARAELNQANEDVARNQERQAKAVQVYNSRKSELDAANKTLADAIAEIKQFNRFAHDPMAGGHRMWQMAGLKAQRAQTDVNNKQAAFDAAAKEKSDADAALSSAMESRKKKEDKKRSAENNLNDEKNKPRKGFKDYGHDYHPAPKTENIKGLGDLKPGIPKTPKQNGGGKRKRWTGDKGRKIYEWDSQHGELEGYRASDGQHLGSFDPKTGNQLKGPDPKRNIKKYL,negative +TCCCTACGGCGCTAACGGATCAAACATGCGCTCCAAGGAGTAGGGGCCACCGTGCTACAAC,VVIRSNNFTDNAKTIIVQLNESIAINCTRPNNNTRKSIHIGPGRAFYTTGDIIGNIRQAHCNLSRTKWENTLKQIAKKLREQFGNKTIVFNH,negative +CTTCTGCCCGCCTCCTTCCGTTTTCCTGCGGCAGCGTTTTGTTGCTTTCGTTCCTCCGGGAGACGAGATAGGCGGACACT,RRIKRLEQEKLELSRKLQESTQTVQALQYSTVDGPLTASKDLEIKNLKEEIEKLRKQVTESSHLEQQLEEANAVRQELDDAFRQIKAYEKQIKTLQQEREDLNKELVQASERLKNQSKELKDAHCQRKLAMQEFMEINER,negative +AATTTCTAATATAATTTCTAATAT,MASNFTQFVLVDNGGTGDVTVAPSNFANGVAEWISSNSRSQAYKVTCSVRQSSAQNRKYTIKVEVPKVATQTVGGVELPVAAWRSYLNMELTIPIFATNSDCELIVKAMQGLLKDGNPIPSAIAANSGIY,negative +TAGGGAATTTCGACGGATCCAGCUGAUGUGGGACGUCAGUUAUAGGAAUGUGGAGGUUGGAAGUUAUGGCUUGCAUCAGCTGCAGGTCGACGCATGCGCCG,MNIKAILSLCLFLILQCVRARVFVSRLEAASLLARSRRANSPFSMEETKQGSLERECREETCNFEEAREIFEDDQRTNAFWTLYIRPNPCLSNPCQNGGTCQHTHTVYMCVCPRGWEGRVCSQEVSTGQSCKVNNGRCDHYCEEEEAAAGGRRGAVCSCAPGYHLARNRRSCMAMEAFPCGRVASPKSDILMGNSSEAATDVPTPTSQAANVNSSSIIGDDSEPQASFGHSNHRGRVVGGKECPRGQCPWQVLISRKGAPVCGGTILSPQWILTAAHCTIYETKNLRILAGEHNVDEVEGSEQELGILRIVDHPSFNIKLSYDNDISLIQLSRPIQFTRYALPICLPNQRFVRGVLRSVVAGTVSGWGKLNEFGPAAGILQRLEVPYVDDEQCRAAMGSKVITANMFCAGYETGGQDSCSGDSGGPHATRYGSTWFLTGVVSWGKGCAREGKFGVYTKVLNYLDWIAQTMAETESHALPEPAQH,negative +GGGAGGACGAUGCGGACCGAAAAAGACCUGACUUCUAUACUAAGUCUACGUUCCCAGACGACUCGCCCGA,MASTSRLDALPRVTCPNHPDAILVEDYRAGDMICPECDRVIDVGSEWRTFSNDKATKDPSRVGDSQNPLLSDGDLSTMIGKGTGAASFDEFGNSKYQNRRTMSSSDRAMMNAFKEITTMADRINLPRNIVDRTNNLFKQVYEQKSLKGRANDAIASACLYIACRQEGVPRTFKEICAVSRISKKEIGRCFKLILKALETSVDLITTGDFMSRFCSNLCLPKQVQMAATHIA,negative +GUAUUCUCGGUGGUUUAAUCAGAGUAGAGGAGGCUGACUCCUUUGGUUGGACUACGUGGAGGUUCUCUU,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,negative +CTCCTCTGACTGTAACCACGCCGAAGACCTTTTTAGCGTACTGAAAAGGAGTTACTCTCGCATAGGTAGTCCAGAAGCC,MSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEMLDRHHTHFCPLEGESWQDFLRNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAFLCQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERETPTTDSMPPLLRQAIELFDHQGAEPAFLFGLELIICGLEKQLKCESGS,negative +NGACUGAUUUUUCCUUGNCAGUGUAAUUUCCUGGCUGCCC,MDHLNEATQGKEHSEMSNNVSDPKGPPAKIARLEQNGSPLGRGRLGSTGAKMQGVPLKHSGHLMKTNLRKGTMLPVFCVVEHYENAIEYDCKEEHAEFVLVRKDMLFNQLIEMALLSLGYSHSSAAQAKGLIQVGKWNPVPLSYVTDAPDATVADMLQDVYHVVTLKIQLHSCPKLEDLPPEQWSHTTVRNALKDLLKDMNQSSLAKECPLSQSMISSIVNSTYYANVSAAKCQEFGRWYKHFKKTKDMMVEMDSLSELSQQGANHVNFGQQPVPGNTAEQPPSPAQLSHGSQPSVRTPLPNLHPGLVSTPISPQLVNQQLVMAQLLNQQYAVNRLLAQQSLNQQYLNHPPPVSRSMNKPLEQQVSTNTEVSSEIYQWVRDELKRAGISQAVFARVAFNRTQGLLSEILRKEEDPKTASQSLLVNLRAMQNFLQLPEAERDRIYQDERERSLNAASAMGPAPLISTPPSRPPQVKTATIATERNGKPENNTMNINASIYDEIQQEMKRAKVSQALFAKVAATKSQGWLCELLRWKEDPSPENRTLWENLSMIRRFLSLPQPERDAIYEQESNAVHHHGDRPPHIIHVPAEQIQQQQQQQQQQQQQQQAPPPPQPQQQPQTGPRLPPRQPTVASPAESDEENRQKTRPRTKISVEALGILQSFIQDVGLYPDEEAIQTLSAQLDLPKYTIIKFFQNQRYYLKHHGKLKDNSGLEVDVAEYKEEELLKDLEESVQDKNTNTLFSVKLEEELSVEGNTDINTDLKD,negative +AAGACGGCCGGGGAAACCCGAGAUCCGAGGUAACGC,IMEIRTVAVGIVAIKGVESEYYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHSGGEMFVALNQKGLPVKGKKTKKEQKTAHFLPMAIT,negative +GCUUGGUACCGAGCUCGGAUCCACGUAGUAACGGGCCGCCAGUGUGCUGGAAUUCGGGUCGUUCUUG,LQENFLPQPRQQHHGTLVLHYRPHREEAGMQHPCLWPGSSHCSDDSTLRRLQCESVTSIGAVCP,negative +GGAGUCUUAGGCAGCGCGUUUUCGAGCUACUCCA,MSSSQKKAGGKAGKPTKRSQNYAALRKAQLPKPPALKVPVVKPTNTILPQTGCVWQSLGTPLSLSSFNGLGARFLYSFLKDFVGPRILEEDLIYRMVFSITPSHAGTFCLTDDVTTEDGRAVAHGNPMQEFPHGAFHANEKFGFELVFTAPTHAGMQNQNFKHSYAVALCLDFDAQPEGSKNPSFRFNEVWVERKAFPRAGPLRSLITVGLFDEADDLDRH,negative +ATCACTAGTGAATTCGCGGCCGCCTGCAGGTCGACCATAT,MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQRGLKNVFDEAILAALEPPETQPKRKCCIF,negative +UGUUUGGCUUGGCUCUGCAUCGACAGGUGGUU,PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGKISKIGPENPYNTPVFAIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDESFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPXRXKNPEMVIYQYMDDLYVGSDLEIGQHRAKIEELRSHLLSWGFTTPDKKHQKEPPFLWMGYELHPDSWTVQPIELPEKDSWTVNE,negative +AGTTTGGCGGGTAGTGGATATCAAGACTATTTGATGCCGA,MDSTNYISKLFEYAQRQGQISDIKFEEVGTDGPDHLKTFTLRVVIKGHAYPNGVGKTKKEAKRNAAKHALIGMMETTEQKDASVSCPPSPAPSPAPPVRAVISQPKYVSWLNEHSQKNKLSLKALEGARVGPNNTSQCCRYVVGEKEYPEGFGNTKKEAKEEAAMQVYLELCGGSQTTGTVDENCNGTTGKHKEELNGKVVVLSEKVEHMNMSPAQNVPEQYSFITTEETNFIGILNHYCQKTKRFLDFKLVEKSGPSHNPQFVYKVLIDKREYPDGLGKTAKEAKQQAAQLAWSALQEQSDWNSQVSCRSTVSEEGGLSSLTPSSTWESQDATPSSLSIAGSTSESIIFSDSVNVSSPKDESPVNVKPKIRLAANFQMSPVKTKQEGPNLKGNDLGTLSSGRTSNQPVISRFSSEFDSIENIGKGGFGHVYKARRKLEQKYFAVKIVRSKGKAKREVGALADLQHPNIVRYYTAWLEDTAYRCDTASESDTTSDSGSSSSSEFLYIQMELCDKRTLKVWIDERNAHRKPKRREESLSITQQIVNGVEYIHSKKLLHRDLKPANIMFGMSDGEGKGEVKIGDFGLVTAEDNDNDENLLERTKKTGTVSYMAPEQRNQTSYDRKVDIFALGLIYFEPLWDLSGMEKAKVWNDVRSQRFPQQFNSQFTLENKVIESLLCANPEERPDARQLKTKLNECSRVLTRVHNIHQDNRTI,negative +UCAUGGUGUCUUUCCACAGCUCUUCCCAUGAUCGCCCGG,MLNQLDNLTERVRGSNKLVDRWLHVRKHLLVAYYNLVGIKPGKESYMRLNEKALDDFCQSLVDYLSAGHFSIYERILHKLEGNGQLARAAKIWPQLEANTQQIMDYYDSSLETAIDHDNYLEFQQVLSDIGEALEARFVLEDKLILLVLDAARVKHPA,negative +GCAGAACCACCCCCUUCCAUCACUCCAGCC,WPLTEEKIKALVEICXEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEEFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDXIIYQYMDDLYVGSDLEIGQHRTKVEELRQHLLXWGFTTPDKKHQKEPPFLWMGYELHP,negative +UCAAGAAUUCCGUUUUCAGUCGGGAAAAACUGAACAA,MSMSPKHTTPFSVSDILSPLEESYKKVGMEGGGLGAPLAAYRQGQAAPPAAAMQQHAVGHHGAVTAAYHMTAAGVPQLSHSAVGGYCNGNLGNMSELPPYQDTMRNSASGPGWYGANPDPRFPAISRFMGPASGMNMSGMGGLGSLGDVSKNMAPLPSAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGGGGGGGAGCPQQQQAQQQSPRRVAVPVLVKDGKPCQAGAPAPGAGSLQGHAQQQAQQQAQAAQAAAAAISVGSGGPGLGAHPGHQPGSAGQSPDLAHHAASPAALQGQVSSLSHLNSSGSDYGTMSCSTLLYGRTW,negative +AATACCCTCCCTTCGGTGCAAAGCACCGAAGGGAGGG,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,negative +GCAAUGACCAAGGUACCGACCCUAUGGCUCCGGCCUGCGU,MAGRSGDSDEELLKAVRLIKFLYQSNPPPNPEGTRQARRNRRRRWRERQRQIHSISERILSTYLGRSAEPVPLQLPPLERLTLDCNEDCGTSGTQGVGSPQILVESPTILESGAKE,negative +GUACAACACAUCAUUACGGCUGCUAUUGGCUCCAAGCGUCUUUCUCCCUGGUCAAUAGUCCGCCACCACG,MAGRSGDSDEELLKAVRLIKFLYQSNPPPNPEGTRQARRNRRRRWRERQRQIHSISERILSTYLGRSAEPVPLQLPPLERLTLDCNEDCGTSGTQGVGSPQILVESPTILESGAKE,negative +ACAACCCGGAACAACGUCUAACAGUGUACCAUAACCCGGCAUUCA,MEGMLKGEGPGPLPPLLQQYVELRDQYPDYLLLFQVGDFYECFGEDAERLARALGLVLTHKTSKDFTTPMAGIPLRAFEAYAERLLKMGFRLAVADQVEPAEEAEGLVRREVTQLLTPGTLLQESLLPREANYLAAIATGDGWGLAFLDVSTGEFKGTVLKSKSALYDELFRHRPAEVLLAPELLENGAFLDEFRKRFPVMLSEAPFEPEGEGPLALRRARGALLAYAQRTQGGALSLQPFRFYDPGAFMRLPEATLRALEVFEPLRGQDTLFSVLDETRTAPGRRLLQSWLRHPLLDRGPLEARLDRVEGFVREGALREGVRRLLYRLADLERLATRLELGRASPKDLGALRRSLQILPELRALLGEEVGLPDLSPLKEELEAALVEDPPLKVSEGGLIREGYDPDLDALRAAHREGVAYFLELEERERERTGIPTLKVGYNAVFGYYLEVTRPYYERVPKEYRPVQTLKDRQRYTLPEMKEKEREVYRLEALIRRREEEVFLEVRERAKRQAEALREAARILAELDVYAALAEVAVRYGYVRPRFGDRLQIRAGRHPVVERRTEFVPNDLEMAHELVLITGPNMAGKSTFLRQTALIALLAQVGSFVPAEEAHLPLFDGIYTRIGASDDLAGGKSTFMVEMEEVALILKEATENSLVLLDEVGRGTSSLDGVAIATAVAEALHERRAYTLFATHYFELTALGLPRLKNLHVAAREEAGGLVFYHQVLPGPASKSYGVEVAAMAGLPKEVVARARALLQAMAARREGALDAVLERLLALDPDRLTPLEALRLLQELKALALGAPLDTMKG,negative +CUUGCCGUAGACCCAUUUUCCAAUCACAAGUCACGCGUCUCAAGCUGUUA,MASNFTQFVLVDNGGTGDVTVAPSNFANGVAEWISSNSRSQAYKVTCSVRQSSAQNRKYTIKVEVPKVATQTVGGVELPVAAWRSYLNMELTIPIFATNSDCELIVKAMQGLLKDGNPIPSAIAANSGIY,negative +CCACCAGCCCAGAGAUAGCCCAGACACCACCAAGAC,MPEEWVRIFGEAGITQFEQQRNPRLCLSVLNILSKSEHPQEKFMFVPYEQSALPVTDNSPFGDTSITHNYADHHFKASTPENEGSSFYSRVPGPCTVGVRSSSLSSGRGSSEGVGSRSGSGSGGAASRSSSSGHGGAGFPLPVTSVPANGRSSAPGPNSMTVTSGSHSSSGSNCSTGSLTGGMELTNTMVATTQRTGPNNVLVNGHSTGNHFHGGVTQRVAASAAPTECNVLPTYTGSSSSYQPTSFQSMAVHTPPAYTLRQIPPAHSIGYPYTSTAPTSESIILTAPTTTPSSTVYHTTQGSAIVKPLSDNQSQRDKLPYLMHKSQWHSNVTGHVPLSPGLPRRFVDGVLPPETSAHIQYSSGQSSPSPAGSATPVPTPRRESLAGSVPVRAGPAPPALATHELSSDANCTLTPPPVATRPEKTKSIYTKPVEAQCDGHLTIGDQQDASRRSLETPVPPQTAATIHGSENETRTNVTVLPTVHSDGNNSSVHAYQQATESRPLKPNTLERQGQKKVRPKISDEAIQEKLRMIVSIGDPNRKYQRQEKIGQGASGTVYGGIEVATGRRVAIKQMNLKQQPKKELIVNEIYVMKAKKHPNVVNYLDSYLVADELWVVMEYLDGGSLTEVVTETYMEEGQIAAVCRECLQALDFLHKNQVIHRDIKSDNILLGLDGSVKLTDFGFCAQLSSEQNKRSTMVGTPYWMAPEVVTRKQYGPKVDIWSLGIMAIEMLDGEPPYLNENPVRALYLIGTNGKPEIKERDKLSSEFQDFLDLCLEVKVERRATAQELLQHIFSRDGHRAMELLQTDNFHSSGVRKKRTPRLAIEKLVDPEVKRNYQNQLVECLPDGTVSDINGHWEKISKALLKPRRTVVMAAGEDELVVTVRGTSFNCPPTSLVEPNTGIIAPLIEPHHRGIGSYALEVVADIIGTLDYCGIAFLTMGSFVPYLYYSFYCVLWLKLFYLALIFALGSGAIAVSMSNTFASPAYRPLRALVFIALGLSGVIPCVHVTITNGFWPSLQHGSLGWLFLMAVLYITGASIYAVRVPERIFPGRFDIWFQSHQIFHVFVVAAALVHYHGIIGLTNYRLAIGDCRPPPGYPFPKHDYDNIELLRPFMTY,negative +GGGGGGGGTGGGGTGGGTCAATATTCTCGTC,MAGPQALAFGLLLAVVTATLAAAQRDCVCDNYKLATSCSLNEYGECQCTSYGTQNTVICSKLASKCLAMKAEMTHSKSGRRIKPEGAIQNNDGLYDPDCDEQGLFKAKQCNGTATCWCVNTAGVRRTDKDTEITCSERVRTYWIIIELKHKERESPYDHQSLQTALQEAFTSRYKLNQKFIKNIMYENNVITIDLMQNSSQKTQDDVDIADVAYYFEKDVKGESLFHSSKSMDLRVNGEPLDLDPGQTLIYYVDEKAPEFSMQGLTAGIIAVIVVVSLAVIAGIVVLVISTRKKSAKYEKAEIKEMGEIHRELNA,negative +AAGACGGCCCGGUGUGUAGCCGGAGAUCCGAGACUUGCU,MASTSRLDALPRVTCPNHPDAILVEDYRAGDMICPECDRVIDVGSEWRTFSNDKATKDPSRVGDSQNPLLSDGDLSTMIGKGTGAASFDEFGNSKYQNRRTMSSSDRAMMNAFKEITTMADRINLPRNIVDRTNNLFKQVYEQKSLKGRANDAIASACLYIACRQEGVPRTFKEICAVSRISKKEIGRCFKLILKALETSVDLITTGDFMSRFCSNLCLPKQVQMAATHIA,negative +CCTAGTGTGCGTCGATGGGGTGGGGTGGGGCTGAGTTGGGGGGTGGGATCAATCAATCTGGTTT,PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGKISKIGPENPYNTPVFAIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDESFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPXRXKNPEMVIYQYMDDLYVGSDLEIGQHRAKIEELRSHLLSWGFTTPDKKHQKEPPFLWMGYELHPDSWTVQPIELPEKDSWTVNE,negative +TATTAGTAATAATATTAGTAATAA,MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC,negative +ATACCAGCTTATTCAATTACAGTAGTGAGGGGTCCGTCGTGGGGTAGTTGGGTCGTGGAGATAGTAAGTGCAATCT,MPVKMVAVLGASTVLWILFAVSQAFKIEISPEYKTIAQIGDSMALTCSTTGCESPLFSWRTQIDSPLNAKVRTEGSKSVLTMEPVSFENEHSYLCTATCGSGKLERSIHVDIYSFPKDPEIQFSGPLEVGKPVTVKCLAPDIYPVYRLEIDLFKGDQLMNRQEFSSEEMTKSLETKSLEVTFTPVIEDIGKALVCRAKLHIDQIDSTLKERETVKELQVYISPRNTTISVHPSTRLQEGGAVTMTCSSEGLPAPEIFWGRKLDNEVLQLLSGNATLTLIAMRMEDSGVYVCEGVNLIGRDKAEVELVVQEKPFIVDISPGSQVAAQVGDSVVLTCAAIGCDSPSFSWRTQTDSPLNGVVRNEGAKSTLVLSSVGFEDEHSYLCAVTCLQRTLEKRTQVEVYSFPEDPVIKMSGPLVHGRPVTVNCTVPNVYPFDHLEIELLKGETTLMKKYFLEEMGIKSLETKILETTFIPTIEDTGKSLVCLARLHSGEMESEPKQRQSVQPLYVNVAPKETTIWVSPSPILEEGSPVNLTCSSDGIPAPKILWSRQLNNGELQPLSENTTLTFMSTKRDDSGIYVCEGINEAGISRKSVELIIQVSPKDIQLTVFPSKSVKEGDTVIISCTCGNVPETWIILKKKAKTGDMVLKSVDGSYTIRQAQLQDAGIYECESKTEVGSQLRSLTLDVKGKEHNKDYFSPELLALYCASSLVIPAIGMIVYFARKANMKGSYSLVEAQKSKV,negative +UGGGGUAUCGCCAAAAGAAAGGCACCGGAUUCUGAUUCCGGAGGUCGAGAUUGUCGUCCUCGUACCCCAGCCA,MAGRSGDSDEELLKAVRLIKFLYQSNPPPNPEGTRQARRNRRRRWRERQRQIHSISERILSTYLGRSAEPVPLQLPPLERLTLDCNEDCGTSGTQGVGSPQILVESPTILESGAKE,negative +CGCGGATCCTGCAGCTCGAGAGCGGTGGGTGTTTACGTGTTTTTGTTTACCTCTAGAAGCTTGTCGAC,QDRPIKFSTEGATSQSYKQFIEALRERLRGGLIHDIPVLPDPTTLQERNRYITVELSNSDTESIEVGIDVTNAYVVAYRAGTQSYFLRDAPSSASDYLFTGTDQHSLPFYGTYGDLERWAHQSRQQIPLGLQALTHGISFFRSGGNDNEEKARTLIVIIQMVAEAARFRYISNRVRVSIQTGTAFQPDAAMISLENNWDNLSRGVQESVQDTFPNQVTLTNIRNEPVIVDSLSHPTVAVLALMLFVCNPPNANQSPLLIRSIVEKSKICSSRYEPTVRIGGRDGMCVDVYDNGYHNGNRIIMWKCKDRLEENQLWTLKSDKTIRSNGKCLTTYGYAPGSYVMIYDCTSAVAEATYWEIWDNGTIINPKSALVLSAESSSMGGTLTVQTNEYLMRQGWRTGNNTSPFVTSISGYSDLCMQAQGSNVWMADCDSNKKEQQWALYTDGSIRSVQNTNNCLTSKDHKQGSTILLMGCSNGWASQRWVFKNDGSIYSLYDDMVMDVKGSDPSLKQIILWPYTGKPNQIWLTLF,negative +GUAAGGGUUCACUCUGCAUCGACAACUGGA,MAITKINDCFELLSMVTYADKLKSLIKKEFSISFEEFAVLTYISENKEKEYYLKDIINHLNYKQPQVVKAVKILSQEDYFDKKRNEHDERTVLILVNAQQRKKIESLLSRVNKRITEANNEIEL,negative +GACAGCGUGCCUAGAAGUCCAAGCUUAAAUAACCACGCUCGACAAGC,EFPPSTFYRVTLYGLYKGELLDPVFAEAITEAEPEVEHITVSDITPHSFKVTWTAPEAVFDSFALKVLDSSGLGRPHQISVSGDKRTEAVTGLNEDTDYEIELFGIILGRKFQPIFTVARTGLGTRKGIRFSDVTDTSATVHWTMPHTRVDNYRVIYVPIQGGSPLTLRVDGGESQAMLSNLTPGVTYQVTVIAVKGLEESEPGSERVTTALDKPRGLTAVNISDTEALLLWQPSIATVDGYVITYSADSVAPVMERVSGNTVEFEMSSLTPATLYTVKVYAFRDTAKSAATSTDFTTDVDAPQNLAASNIQTETAMLTWKPPRADISGYILSFESADGVVKEVVLSPTATFYSMSHLTASTEYTVKLQAIAGPKRSRVISTVFLTIGVLYKHPKDCSQALLNGDTTSGFYTIYLRGDESQPLQVYCDMTTDGGGWIVFVRRQSGKVEFFRNWKNYTAGFGDLNDEFWLGLSNLHKITSFGQYELRVDLRDKGESAYAQYDKFSISEPRARYKVHVGGYSGTAGDSMTYHHGRPFSTYDNDNDIAVTNCALSYKGAFWYKNCHRVNIMGRYGDNSHSKGVNWFHWKGHEHSVEFAEMKIRPANFRNFEGRKKRS,negative +AGTCCGTGGTAGGGCAGGTTGGGGTGACT,MVKSHIGSWILVLFVAMWSDVGLCKKRPKPGGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGSHSQWNKPSKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGNDYEDRYYRENMYRYPNQVYYRPVDRYSNQNNFVHDCVNITVKQHTVTTTTKGENFTETDIKIMERVVEQMCITQYQRESQAYYQRGASVILFSSPPVILLISFLIFLIVG,negative +UCCCUGGCCCAAGAUCCUAAUAAAGUUUUUUCGGACCGGAGCGAAACCACUAUCCUCUUAAGCAAUCUGU,MEDDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKEEIAEVANEIESLGSTEERKNMQRNKQVAMGRKKFNMDPKKGIQFLIENGLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERDEFSIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNTGVFQSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIKNEPFKIPVWFFLQNLYESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEDWIKCIKAAISRDPFYEMLAARKKKVSSTKRH,negative +AAGCTCTTAGTTGATGCGCGGTCAAAATTTAAGCT,XQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGSTGSPGPGYGYSNYGFPPYGGITFHPGVTKSNAGVTHGTINTKFKNGPKDCAKSDDEESLTLPEKETEGEGPSLPMACTKTEPIALASTMEDKEQDMGFQDNLFLEKALQLARRHANALFDYAVTGDVKMLLAVQRHLTAVQDENGDSVLHLAIIHLHAQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRVGADLSLLDRWGNSVLHLAAKEGHDRILSILLKSRKAAPLIDHPNGEGLNAIHIAVMSNSLPCLLLLVAAGAEVNAQEQKSGRTALHLAVEYDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWEKAGEDEGVVPGTTPLDMAANWQVFDILNGKPYEPVFTSDDILPQGDMKQLTEDTRLQLCKLLEIPDPDKNWATLAQKLGLGILNNAFRLSPAPSKTLMDNYEMNSGIVTASVTVVWRHPSANSALQSLLLETAHCYL,negative +CUCAGAGACAGAGCAGAAACGACAGUUCAAGCCGAA,MHGDTPTLHEYMLDLQPETTDLYCYEQLNDSSEEEDEIDGPAGQAEPDRAHYNIVTFCCKCDSTLRLCVQSTHVDIRTLEDLLMGTLGIVCPICSQKP,negative +UGACGCGAUCCGCCGUUCCCAUCCGCACGCCCUACACCU,MTRCTADNSLTNPAYRRRTMATGEMKEFLGIKGTEPTDFGINSDAQDLPSPSRQASTRRMSIGESIDGKINDWEEPRLDIEGFVVDYFTHRIRQNGMEWFGAPGLPCGVQPEHEMMRVMGTIFEKKHAENFETFCEQLLAVPRISFSLYQDVVRTVGNAQTDQCPMSYGRLIGLISFGGFVAAKMMESVELQGQVRNLFVYTSLFIKTRIRNNWKEHNRSWDDFMTLGKQMKEDYERAEAEKVGRRKQNRRWSMIGAGVTAGAIGIVGVVVCGRMMFSLK,negative +ATATTCGCGATTATT,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,negative +CCGCCTCCTTCCGATTGAAAGGTCTGTTTTTGGGGTTGGTTTGGGTCAATAGGAGACGAGATAGGCGG,PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKNSKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNRKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFYTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQK,negative +ATACCAGCTTATTCAATTACAGTAGTGAGGGGTCCGTCGTGGGGTAGTTGGGTCGTGGAGATAGTAAGTGCAATCT,QELLCAASLISDRWVLTAAHCLLYPPWDKNFTVNDILVRIGKYARSRYERNMEKISTLEKIIIHPGYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDKQIVTSLLQAGHKGRVTGWGNLKEMWTVNMNEVQPSVLQMVNLPLVERPICKASTGIRVTDNMFCAGYKPEEGKRGDACEGDSGGPFVMKNPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIRKMVDRFG,negative +AGCAAGGGCCACUGCAAAGCACGCGAGCAU,PHITDVVLDKANKTPLRQLDPSRLPDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFAKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRQSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPINRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDTASEATRPATLNRFSALQQTLPAENTDNRRVVQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRTRTPATKRSFSKEVEERSRERPSQPEGLRKAASLTEDRGRDPVKREATLPPVSPPKAALSVDEVEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRLGIESTLERSTIAREHMGRLLHQLLCAGHLSTAQYYQGLYETLELAEDMEIDIPHVWLYLAELITPILQEDGVPMGELFREITKPLRPMGKATSLLLEILGLLCKSMGPKKVGMLWREAGLSWREFLAEGQDVGSFVAEKKVEYTLGEESEAPGQRTLAFEELRRQLEKLLKDGGSNQRVFDWIDANLNEQQIASNTLVRALMTTVCYSAIIFETPLRVDVQVLKVRARLLQKYLCDEQKELQALYALQALVVTLEQPANLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFNWLREAEDEESDHN,negative +GACUAAACGCAUUGUGCCCC,MNRNCASPEEGGTTEQLVKEASDIVERDGFENKKKPPTLKLEHVEVVGEKSPTPATVYDLFKKYKKPDIVTNSNGDDMNVGFDQLSSDEKNGFLRKLQMLTVSSRKSVKVVGESTPSSAGRLLKKFAPSRKPTEKISVDEPPSRFNFFGRSTKKLSDSDRPSSLPKKKSARRLLFGKEEQKPEPEVVKNRVLPAMTSQQSAKGAPIPINKPYRYQGPRGSLETPTDSPAKISSNSSSSSPIPPVPTRNHFTSMNEESPSKKRTFSRQGLSNRDNLSNGSWHGELPPRDYTSPTFSRKIFVGGVPWDITEAALKDSFGEFGSCAVEWPGQEARYRSGQSNIAPLTNLRNQSKYAGQAATGYVYMIFEDERAVASLLHECSQEIGGAGEWYFKIRAQRSKSTEIRQVQIIPWVTSDSMFCEDESLLETGIEPKRTVFVGALHGMMTAQVLHWIMEDCFGSVECVQLDTDKFKYPIGSGRVTFREHGAYFKAIEMGYLHVHTSKFRKRVQIDPFLESTSCMVCTTESAQCFCRNRNCFKYYCHTCWAIDHGKDNADDVHVPVIVPSSASKAYAGPHRRPHLTSNSLSKSHGCSTNNQLSHVLSPGFPMIVGGPSQTLSALYGYIQNNQQMMLTPAVYETPMTPPSNESNAKRRSFTEFQNPAIFFNPSSMMTPQKSATCSETPVPAFFTNSAAFLTPNSNYYGSPNHSSSNISQSPQQYYGANLYYGYMPPQVAYDGSTNGSKLSPIHVPHIPNYQ,negative +GGACCUUUGUACCCCAGAUGAUAGUGAGGCGCGGCUUGAUGGGUACAAAUGGCAG,MAMQMQLEANADTSVEEESFGPQPISRLEQCGINANDVKKLEEAGFHTVEAVAYAPKKELINIKGISEAKADKILAEAAKLVPMGFTTATEFHQRRSEIIQITTGSKELDKLLQGGIETGSITEMFGEFRTGKTQICHTLAVTCQLPIDRGGGEGKAMYIDTEGTFRPERLLAVAERYGLSGSDVLDNVAYARAFNTDHQTQLLYQASAMMVESRYALLIVDSATALYRTDYSGRGELSARQMHLARFLRMLLRLADEFGVAVVITNQVVAQVDGAAMFAADPKKPIGGNIIAHASTTRLYLRKGRGETRICKIYDSPCLPEAEAMFAINADGVGDAKD,negative +TCCGGCGCGCTGAGTGCCGGTTATCCTCGT,MKPGGNTIVIWMYAVATWLCFGSTSGWSFTLEDNNIFPKQYPIINFTTAGATVQSYTNFIRAVRGRLTTGADVRHEIPVLPNRVGLPINQRFILVELSNHAELSVTLALDVTNAYVVGYRAGNSAYFFHPDNQEDAEAITHLFTDVQNRYTFAFGGNYDRLEQLAGNLRENIELGNGPLEEAISALYYYSTGGTQLPTLARSFIICIQMISEAARFQYIEGEMRTRIRYNRRSAPDPSVITLENSWGRLSTAIQESNQGAFASPIQLQRRNGSKFSVYDVSILIPIIALMVYRCAPPPSSQFSLLIRPVVPNFNADVCMDPEPIVRIVGRNGLCVDVRDGRFHNGNAIQLWPCKSNTDANQLWTLKRDNTIRSNGKCLTTYGYSPGVYVMIYDCNTAATDATRWQIWDNGTIINPRSSLVLAATSGNSGTTLTVQTNIYAVSQGWLPTNNTQPFVTTIVGLYGLCLQANSGQVWIEDCSSEKAEQQWALYADGSIRPQQNRDNCLTSDSNIRETVVKILSCGPASSGQRWMFKNDGTILNLYSGLVLDVRASDPSLKQIILYPLHGDPNQIWLPLF,negative +GGGCUAGCUGAUCGUACCCAUAGCGUGGGCAUGGGGUGCCUAGUCGGGCGAUACUAACAGCUAACACCC,MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP,negative +TATTAGCAATAATATTAGCAATAA,MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINYDEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQAVAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQGIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADMDFSALLSQISS,negative +GGGAUCGUGGUAGUGCGAAGCCAGUAAACGAGGGCACCACGGUCC,MNIKAILSLCLFLILQCVRARVFVSRLEAASLLARSRRANSPFSMEETKQGSLERECREETCNFEEAREIFEDDQRTNAFWTLYIRPNPCLSNPCQNGGTCQHTHTVYMCVCPRGWEGRVCSQEVSTGQSCKVNNGRCDHYCEEEEAAAGGRRGAVCSCAPGYHLARNRRSCMAMEAFPCGRVASPKSDILMGNSSEAATDVPTPTSQAANVNSSSIIGDDSEPQASFGHSNHRGRVVGGKECPRGQCPWQVLISRKGAPVCGGTILSPQWILTAAHCTIYETKNLRILAGEHNVDEVEGSEQELGILRIVDHPSFNIKLSYDNDISLIQLSRPIQFTRYALPICLPNQRFVRGVLRSVVAGTVSGWGKLNEFGPAAGILQRLEVPYVDDEQCRAAMGSKVITANMFCAGYETGGQDSCSGDSGGPHATRYGSTWFLTGVVSWGKGCAREGKFGVYTKVLNYLDWIAQTMAETESHALPEPAQH,negative +CCUGUGUCUUGUGUGUGUGUUUUGUUUCUGGUCUA,MGVLLTQRTLLSLVLALLFPSMASMAAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQGLDVPKLREHCRERPGAFPSEETLRGLGRRGFLQTLNATLGCVLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILGLRNNIYCMAQLLDNSDTAEPTKAGRGASQPPTPTPASDAFQRKLEGCRFLHGYHRFMHSVGRVFSKWGESPNRSRRHSPHQALRKGVRRTRPSRKGKRLMTRGQLPR,negative +GGGAGAAUUCAACUGCCAUCUAUAGAAGAUGAUGCCUGGAUACAAUACAGCCACUCCUCGACUGUAAACCGAGUCCAGAAGCUUGUAGU,MVDREQLVQKARLAEQAERYDDMAAAMKNVTELNEPLSNEERNLLSVAYKNVVGARRSSWRVISSIEQKTSADGNEKKIEMVRAYREKIEKELEAVCQDVLSLLDNYLIKNCSETQYESKVFYLKMKGDYYRYLAEVATGEKRATVVESSEKAYSEAHEISKEHMQPTHPIRLGLALNYSVFYYEIQNAPEQACHLAKTAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDQQDDDGGEGNN,negative +TATTAGTACTAATATTAGTACTAA,MHGDTPTLHEYMLDLQPETTDLYCYEQLNDSSEEEDEIDGPAGQAEPDRAHYNIVTFCCKCDSTLRLCVQSTHVDIRTLEDLLMGTLGIVCPICSQKP,negative +GCCAGCATCCCGACTGGGCTCCTCGATAACGAGTGCCCG,MIPPPRRSASSTPKDYRSSRDLQPWRGVSSGDAAETSQQSRHRRDAIADGGGRLKGAAQSSPSSGTRRSGPYAQGRAMPKNENIPKPGKQRLGPRKKKLSTLKKKILLDRLERWRDKQHEGALSTPSATASSEEAKCNNPFPLCPPGELSPPPSPPATICPAVVDKSTSYGQVGGANGERSVWAITIYNLVDQEDVEDDDDHAEIERDLWDMSSAFGVVRSVQVPRGTAVQVSDAEVSAAAAAGEPAAVAAKVAFATNAEAECARDGLNGRIVGGKPLLVRIHRCDGHFCGGVCPGDPDGSGLWRVAIENLIDEEDDLDDEDEYAEISANVSAMMGCYGKLVDVQVRRSSPSKGEVQEDVATRAATTAGATQAVVVTFGSLAEAEACVQGIKGCRVGGKELDAHVVLDSERVLPSNPAFKCDQEHAHSSDVAAAVAGQGDSMMKQEAGTEPSPCVDQDTAAAVASSTEWRVVIRGLIDEDDLQDDDDDYAEVCSDVTALVSSYGAVVGLDIPRGRETGSCCYGAEPGEAVVVFRSLQEAEACARGLSGRKVAGNILDAQVLTQPAPSQQGPLQGGASGTGPPVANRERKPAKECPLPQHQASSHQSCGKVPELDGSGPGMLRGFGNRVEDCCGRPKIACTDSDEPQAIAAAAPPGQSIEGPKTTALAKAGKRIQTKYQEAAALPKPPGVRGGLPNAYVNQPPDKEVNDLVFEMLQLLFKFQERARLSDPSKAKTRRRLVIGLREVLRGVKAKKVRLLIVAPNVDAVGGEGGLDDKVVEIIDKAREAEYPVVFALSKRKIGKALGKTIKVSAVGVYSFDGANEQQKQLKRRMETISSLPSPSPRQSDPPTDDALASPPSSSACGDSQDPAGKGSRV,negative +AATACCCCCCCTTCGGTGCCTCTTCAGTTAAAAATAACTGAAGAGGCACCGAAGGGGGGG,PHITDVVLDKANKTPLRQLDPSRLPDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFAKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRQSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPINRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDTASEATRPATLNRFSALQQTLPAENTDNRRVVQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRTRTPATKRSFSKEVEERSRERPSQPEGLRKAASLTEDRGRDPVKREATLPPVSPPKAALSVDEVEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRLGIESTLERSTIAREHMGRLLHQLLCAGHLSTAQYYQGLYETLELAEDMEIDIPHVWLYLAELITPILQEDGVPMGELFREITKPLRPMGKATSLLLEILGLLCKSMGPKKVGMLWREAGLSWREFLAEGQDVGSFVAEKKVEYTLGEESEAPGQRTLAFEELRRQLEKLLKDGGSNQRVFDWIDANLNEQQIASNTLVRALMTTVCYSAIIFETPLRVDVQVLKVRARLLQKYLCDEQKELQALYALQALVVTLEQPANLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFNWLREAEDEESDHN,negative +GGGAGGACGCGUCGCCGUAAUGGAUGUUUUGCUCCCUG,ASFTCLAIWALASAGVVPLVLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAAFFFVPVIISTVCYVSIIRCLSSSAVANRSKK,negative +ATACCAGTCTATTCAATTGGGCCCGTCCGTATGGTGGGTGTGCTGGCCAGATAGTATGTGCAATCA,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +TCGAATAGCCCCCCGCGTCCGTCTTCCTTTAGCGATCTATGCTCCTTTGTATGGTCGGGC,MPSKKNGRSGPQPHKRWVFTLNNPSEDERKKIRELPISLFDYFIVGEEGNEEGRTPHLQGFANFVKKQTFNKVKWYLGARCHIEKAKGTDQQNKEYCSKEGNLLMECGAPRSQGQRSDLSTAVSTLLESGSLVTVAEQHPVTFVRNFRGLAELLKVSGKMQKRDWKTNVHVIVGPPGCGKSKWAANFADPETTYWKPPRNKWWDGYHGEEVVVIDDFYGWLPWDDLLRLCDRYPLTVETKGGTVPFLARSILITSNQTPLEWYSSAAVPAVEALYRRITSLVFWKNATEQSTEEGGQFVTLSPPCPEFPYEINY,negative +GATACACGGGCGGAGGAGGTGGGGGGGGGTAGGTGGGTAT,MAGRSGDSDEELLKAVRLIKFLYQSNPPPNPEGTRQARRNRRRRWRERQRQIHSISERILSTYLGRSAEPVPLQLPPLERLTLDCNEDCGTSGTQGVGSPQILVESPTILESGAKE,negative +CTCCTCTGACTGTAACCACGCCGAAGAGCCTTTTTAGCGTACTGAAAAGGAGTTACTCTCGCATAGGTAGTCCAGAAGCC,MDHLNEATQGKEHSEMSNNVSDPKGPPAKIARLEQNGSPLGRGRLGSTGAKMQGVPLKHSGHLMKTNLRKGTMLPVFCVVEHYENAIEYDCKEEHAEFVLVRKDMLFNQLIEMALLSLGYSHSSAAQAKGLIQVGKWNPVPLSYVTDAPDATVADMLQDVYHVVTLKIQLHSCPKLEDLPPEQWSHTTVRNALKDLLKDMNQSSLAKECPLSQSMISSIVNSTYYANVSAAKCQEFGRWYKHFKKTKDMMVEMDSLSELSQQGANHVNFGQQPVPGNTAEQPPSPAQLSHGSQPSVRTPLPNLHPGLVSTPISPQLVNQQLVMAQLLNQQYAVNRLLAQQSLNQQYLNHPPPVSRSMNKPLEQQVSTNTEVSSEIYQWVRDELKRAGISQAVFARVAFNRTQGLLSEILRKEEDPKTASQSLLVNLRAMQNFLQLPEAERDRIYQDERERSLNAASAMGPAPLISTPPSRPPQVKTATIATERNGKPENNTMNINASIYDEIQQEMKRAKVSQALFAKVAATKSQGWLCELLRWKEDPSPENRTLWENLSMIRRFLSLPQPERDAIYEQESNAVHHHGDRPPHIIHVPAEQIQQQQQQQQQQQQQQQAPPPPQPQQQPQTGPRLPPRQPTVASPAESDEENRQKTRPRTKISVEALGILQSFIQDVGLYPDEEAIQTLSAQLDLPKYTIIKFFQNQRYYLKHHGKLKDNSGLEVDVAEYKEEELLKDLEESVQDKNTNTLFSVKLEEELSVEGNTDINTDLKD,negative +AGUGAGGUCAACGAUCUUGGGCCCGUUGACGGGAAGCGUAGAACUACAAGCUUCUGGACUCGGU,MAIPKELLVLLLGIAILSKVAECAAFGSRRGLVETVFDVTRFGARPNTPADSTRGLMMAWRSACQSPGPAKVVIPPGTYTTGETIFQGPCTSPRPITIEIQGTLLSNTDMSLYTRAAWISIEHVDGIVITGGGTLNGQGKSSWQFADKSGSTPPLPSSLVFQTVRSSSIKNLNFVDAKGVHLKITDSSDISVSNIKITAPGDSPNTDGLHISDTINVNVTDSTIGTGDDCISIGDGNSNVYISNINCGPGHGISIGSLGKRLDETDVKGVTVRNCTFRGTTNGARIKTYMGSPSLQVSGVVYEDIILDNVKNPIVIDQHYHSKNRNEPSRVKLVDIHFRNIRGTTTSKIPVLLNCSEALPCEGVELVDIDLAPVGSIGPLLPATCQNAKTILNGKNNPPAC,negative +CCCUGAUGGUAGACGCCGGGGUGCCGGAA,MKKRKVLIPLMALSTILVSSTGNLEVIQAEVKQENRLLNESESSSQGLLGYYFSDLNFQAPMVVTSSTTGDLSIPSSELENIPSENQYFQSAIWSGFIKVKKSDEYTFATSADNHVTMWVDDQEVINKASNSNKIRLEKGRLYQIKIQYQRENPTEKGLDFKLYWTDSQNKKEVISSDNLQLPELKQKSSNSRKKRSTSAGPTVPDRDNDGIPDSLEVEGYTVDVKNKRTFLSPWISNIHEKKGLTKYKSSPEKWSTASDPYSDFEKVTGRIDKNVSPEARHPLVAAYPIVHVDMENIILSKNEDQSTQNTDSQTRTISKNTSTSRTHTSEVHGNAEVHASFFDIGGSVSAGFSNSNSSTVAIDHSLSLAGERTWAETMGLNTADTARLNANIRYVNTGTAPIYNVLPTTSLVLGKNQTLATIKAKENQLSQILAPNNYYPSKNLAPIALNAQDDFSSTPITMNYNQFLELEKTKQLRLDTDQVYGNIATYNFENGRVRVDTGSNWSEVLPQIQETTARIIFNGKDLNLVERRIAAVNPSDPLETTKPDMTLKEALKIAFGFNEPNGNLQYQGKDITEFDFNFDQQTSQNIKNQLAELNATNIYTVLDKIKLNAKMNILIRDKRFHYDRNNIAVGADESVVKEAHREVINSSTEGLLLNIDKDIRKILSGYIVEIEDTEGLKEVINDRYDMLNISSLRQDGKTFIDFKKYNDKLPLYISNPNYKVNVYAVTKENTIINPSENGDTSTNGIKKILIFSKKGYEIG,negative +AGAAAAAAACAAUCCACAGAACAGCGCGUG,MASNFTQFVLVDNGGTGDVTVAPSNFANGVAEWISSNSRSQAYKVTCSVRQSSAQNRKYTIKVEVPKVATQTVGGVELPVAAWRSYLNMELTIPIFATNSDCELIVKAMQGLLKDGNPIPSAIAANSGIY,negative +ACCUUCUGUUCAUAUCGUGACCAACCCAAUAGAUUGUGAUAAAGGAGGAGGAGGA,LQENFLPQPRQQHHGTLVLHYRPHREEAGMQHPCLWPGSSHCSDDSTLRRLQCESVTSIGAVCP,negative +AGCAGCACAGAGGTCAGATGGGTAGGTAGCCGTGCCGGTTGTGCCATTGATTGTACAGTTCCTATGCGTGCTACCGTGAA,MNPSAAVIFCLILLGLSGTQGIPLARTVRCNCIHIDDGPVRMRAIGKLEIIPASLSCPRVEIIATMKKNDEQRCLNPESKTIKNLMKAFSQKRSKRAP,negative +CAGACCGTAAGGGATGCCGCCTAAACACC,VENLMVQELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFSHFRLFDENNDAAILILLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVN,negative +TCCATTCATGTAACGAACATAGTTTTGGCA,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +TATTAGTAATCATATTAGTAATCA,MDSTNYISKLFEYAQRQGQISDIKFEEVGTDGPDHLKTFTLRVVIKGHAYPNGVGKTKKEAKRNAAKHALIGMMETTEQKDASVSCPPSPAPSPAPPVRAVISQPKYVSWLNEHSQKNKLSLKALEGARVGPNNTSQCCRYVVGEKEYPEGFGNTKKEAKEEAAMQVYLELCGGSQTTGTVDENCNGTTGKHKEELNGKVVVLSEKVEHMNMSPAQNVPEQYSFITTEETNFIGILNHYCQKTKRFLDFKLVEKSGPSHNPQFVYKVLIDKREYPDGLGKTAKEAKQQAAQLAWSALQEQSDWNSQVSCRSTVSEEGGLSSLTPSSTWESQDATPSSLSIAGSTSESIIFSDSVNVSSPKDESPVNVKPKIRLAANFQMSPVKTKQEGPNLKGNDLGTLSSGRTSNQPVISRFSSEFDSIENIGKGGFGHVYKARRKLEQKYFAVKIVRSKGKAKREVGALADLQHPNIVRYYTAWLEDTAYRCDTASESDTTSDSGSSSSSEFLYIQMELCDKRTLKVWIDERNAHRKPKRREESLSITQQIVNGVEYIHSKKLLHRDLKPANIMFGMSDGEGKGEVKIGDFGLVTAEDNDNDENLLERTKKTGTVSYMAPEQRNQTSYDRKVDIFALGLIYFEPLWDLSGMEKAKVWNDVRSQRFPQQFNSQFTLENKVIESLLCANPEERPDARQLKTKLNECSRVLTRVHNIHQDNRTI,negative +GGCAGCGAAAGCAGAAGAAGUAUGUGACCAUGCUUCGGCAACUUCACAUGCGUAGCCAAACCGA,MGLLGILCFLIFLGKTWGQEQTYVISAPKIFRVGASENIVIQVYGYTEAFDATISIKSYPDKKFSYSSGHVHLSSENKFQNSAILTIQPKQLPGGQNPVSYVYLEVVSKHFSKSKRMPITYDNGFLFIHTDKPVYTPDQSVKVRVYSLNDDLKPAKRETVLTFIDPEGSEVDMVEEIDHIGIISFPDFKIPSNPRYGMWTIKAKYKEDFSTTGTAYFEVKEYVLPHFSVSIEPEYNFIGYKNFKNFEITIKARYFYNKVVTEADVYITFGIREDLKDDQKEMMQTAMQNTMLINGIAQVTFDSETAVKELSYYSLEDLNNKYLYIAVTVIESTGGFSEEAEIPGIKYVLSPYKLNLVATPLFLKPGIPYPIKVQVKDSLDQLVGGVPVTLNAQTIDVNQETSDLDPSKSVTRVDDGVASFVLNLPSGVTVLEFNVKTDAPDLPEENQAREGYRAIAYSSLSQSYLYIDWTDNHKALLVGEHLNIIVTPKSPYIDKITHYNYLILSKGKIIHFGTREKFSDASYQSINIPVTQNMVPSSRLLVYYIVTGEQTAELVSDSVWLNIEEKCGNQLQVHLSPDADAYSPGQTVSLNMATGMDSWVALAAVDSAVYGVQRGAKKPLERVFQFLEKSDLGCGAGGGLNNANVFHLAGLTFLTNANADDSQENDEPCKEILRPRRTLQKKIEEIAAKYKHSVVKKCCYDGACVNNDETCEQRAARISLGPRCIKAFTECCVVASQLRANISHKDMQLGRLHMKTLLPVSKPEIRSYFPESWLWEVHLVPRRKQLQFALPDSLTTWEIQGVGISNTGICVADTVKAKVFKDVFLEMNIPYSVVRGEQIQLKGTVYNYRTSGMQFCVKMSAVEGICTSESPVIDHQGTKSSKCVRQKVEGSSSHLVTFTVLPLEIGLHNINFSLETWFGKEILVKTLRVVPEGVKRESYSGVTLDPRGIYGTISRRKEFPYRIPLDLVPKTEIKRILSVKGLLVGEILSAVLSQEGINILTHLPKGSAEAELMSVVPVFYVFHYLETGNHWNIFHSDPLIEKQKLKKKLKEGMLSIMSYRNADYSYSVWKGGSASTWLTAFALRVLGQVNKYVEQNQNSICNSLLWLVENYQLDNGSFKENSQYQPIKLQGTLPVEARENSLYLTAFTVIGIRKAFDICPLVKIDTALIKADNFLLENTLPAQSTFTLAISAYALSLGDKTHPQFRSIVSALKREALVKGNPPIYRFWKDNLQHKDSSVPNTGTARMVETTAYALLTSLNLKDINYVNPVIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVKQLRLSMDIDVSYKHKGALHNYKMTDKNFLGRPVEVLLNDDLIVSTGFGSGLATVHVTTVVHKTSTSEEVCSFYLKIDTQDIEASHYRGYGNSDYKRIVACASYKPSREESSSGSSHAVMDISLPTGISANEEDLKALVEGVDQLFTDYQIKDGHVILQLNSIPSSDFLCVRFRIFELFEVGFLSPATFTVYEYHRPDKQCTMFYSTSNIKIQKVCEGAACKCVEADCGQMQEELDLTISAETRKQTACKPEIAYAYKVSITSITVENVFVKYKATLLDIYKTGEAVAEKDSEITFIKKVTCTNAELVKGRQYLIMGKEALQIKYNFSFRYIYPLDSLTWIEYWPRDTTCSSCQAFLANLDEFAEDIFLNGC,negative +GGCAGCGAGAGCAAAACAAGUAUGAGACCCAGCUACGGCGACUUCUCAUGCGUAGCCAAACCCA,MAGRSGDSDEELLKAVRLIKFLYQSNPPPNPEGTRQARRNRRRRWRERQRQIHSISERILSTYLGRSAEPVPLQLPPLERLTLDCNEDCGTSGTQGVGSPQILVESPTILESGAKE,negative +AAAACCUACAACACACCCCUCAACUUUCCC,MSKSESPKEPEQLRKLFIGGLSFETTDESLRSHFEQWGTLTDCVVMRDPNTKRSRGFGFVTYATVEEVDAAMNARPHKVDGRVVEPKRAVSREDSQRPGAHLTVKKIFVGGIKEDTEEHHLRDYFEQYGKIEVIEIMTDRGSGKKRGFAFVTFDDHDSVDKIVIQKYHTVNGHNCEVRKALSKQEMASASSSQRGRSGSGNFGGGRGGGFGGNDNFGRGGNFSGRGGFGGSRGGGGYGGSGDGYNGFGNDGGYGGGGPGYSGGSRGYGSGGQGYGNQGSGYGGSGSYDSYNNGGGGGFGGGSGSNFGGGGSYNDFGNYNNQSSNFGPMKGGNFGGRSSGPYGGGGQYFAKPRNQGGYGGSSSSSSYGSGRRF,negative +GGGAGCTCAGAATAAACGCTCAACGGTGGTGGGTGGGATGAAGAATGGAGAGGGGTTCGACATGAGGCCCGGATC,AKTALQVPLPHPMQMNALGGYSPASTCNGYGRMGLHQEKLPSDLDGMFIERLDCDMESIIRNDLMDGDTLDFNFDNVLPNQSFPHSVKTTTHSWVSG,negative +TATATATATATATAT,MVKSHIGSWILVLFVAMWSDVGLCKKRPKPGGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGTHGQWNKPSKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGSDYEDRYYRENMHRYPNQVYYRPVDQYSNQNNFVHDCVNITVKEHTVTTTTKGENFTETDIKMMERVVEQMCITQYQRESQAYYQRGASVILFSSPPVILLISFLIFLIVG,negative +CAGCTCAGAAGCTTGATCCTGTGAGCGAAAATCCGGAGTAGAGGAGCAGCTGGGTGCTGACTCGAAGTCGTGCATCTGCA,VENLMVQELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFSHFRLFDENNDAAILILLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVN,negative +CAGGCGTTAGGGAAGGGCGTCGAAAGCAGGGTGGG,MPFVNKQFNYKDPVNGVDIAYIKIPNAGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAGHRLYGIAINPNRVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNRKTYLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLKNFTGLFEFYKLLCVRGIITSKTKSLDKGYNKALNDLCIKVNNWDLFFSPSEDNFTNDLNKGEEITSDTNIEAAEENISLDLIQQYYLTFNFDNEPENISIENLSSDIIGQLELMPNIERFPNGKKYELDKYTMFHYLRAQEFEHGKSRIALTNSVNEALLNPSRVYTFFSSDYVKKVNKATEAAMFLGWVEQLVYDFTDETSEVSTTDKIADITIIIPYIGPALNIGNMLYKDDFVGALIFSGAVILLEFIPEIAIPVLGTFALVSYIANKVLTVQTIDNALSKRNEKWDEVYKYIVTNWLAKVNTQIDLIRKKMKEALENQAEATKAIINYQYNQYTEEEKNNINFNIDDLSSKLNESINKAMININKFLNQCSVSYLMNSMIPYGVKRLEDFDASLKDALLKYIYDNRGTLIGQVDRLKDKVNNTLSTDIPFQLSKYVDNQRLLSTFTEYIKNIINTSILNLRYESNHLIDLSRYASKINIGSKVNFDPIDKNQIQLFNLESSKIEVILKNAIVYNSMYENFSTSFWIRIPKYFNSISLNNEYTIINCMENNSGWKVSLNYGEIIWTLQDTQEIKQRVVFKYSQMINISDYINRWIFVTITNNRLNNSKIYINGRLIDQKPISNLGNIHASNNIMFKLDGCRDTHRYIWIKYFNLFDKELNEKEIKDLYDNQSNSGILKDFWGDYLQYDKPYYMLNLYDPNKYVDVNNVGIRGYMYLKGPRGSVMTTNIYLNSSLYRGTKFIIKKYASGNKDNIVRNNDRVYINVVVKNKEYRLATNASQAGVEKILSALEIPDVGNLSQVVVMKSKNDQGITNKCKMNLQDNNGNDIGFIGFHQFNNIAKLVASNWYNRQIERSSRTLGCSWEFIPVDDGWGERPL,negative +TTCCGGCTATGGTTAAACAAAAGACTAGGGAGGTTATTCA,MGCRRTREGPSKAMIFPWKCQSTQRDLWNIFKLWGWTMLCCDFLAHHGTDCWTYHYSEKPMNWQRARRFCRDNYTDLVAIQNKAEIEYLEKTLPFSRSYYWIGIRKIGGIWTWVGTNKSLTEEAENWGDGEPNNKKNKEDCVEIYIKRNKDAGKWNDDACHKLKAALCYTASCQPWSCSGHGECVEIINNYTCNCDVGYYGPQCQFVIQCEPLEAPELGTMDCTHPLGNFSFSSQCAFSCSEGTNLTGIEETTCGPFGNWSSPEPTCQVIQCEPLSAPDLGIMNCSHPLASFSFTSACTFICSEGTELIGKKKTICESSGIWSNPSPICQKLDKSFSMIKEGDYNPLFIPVAVMVTAFSGLAFIIWLARRLKKGM,negative +UUAGCACAAACAACCCCAGAAGUGCAACGC,MVKSHIGSWILVLFVAMWSDVGLCKKRPKPGGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGTHGQWNKPSKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGSDYEDRYYRENMHRYPNQVYYRPVDQYSNQNNFVHDCVNITVKEHTVTTTTKGENFTETDIKMMERVVEQMCITQYQRESQAYYQRGASVILFSSPPVILLISFLIFLIVG,negative +GGGAGGACGAUGCGGAUCAGCCAUGUUUACGUCACUCCUUGUCAAUCCUCAUCGGCAGACGACUCGCCCGA,LQENFLPQPRQQHHGTLVLHYRPHREEAGMQHPCLWPGSSHCSDDSTLRRLQCESVTSIGAVCP,negative +TATTTGCCCTTGCAGGCCGCAGGAGTGCTAGCAGT,QELLCAASLISDRWVLTAAHCLLYPPWDKNFTVNDILVRIGKYARSRYERNMEKISTLEKIIIHPGYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDKQIVTSLLQAGHKGRVTGWGNLKEMWTVNMNEVQPSVLQMVNLPLVERPICKASTGIRVTDNMFCAGYKPEEGKRGDACEGDSGGPFVMKNPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIRKMVDRFG,negative +CCCCCAUGGCACGCCGAUCACGUUUUGCUGUCCGCCGGUCCAUAAAUACU,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +UAAUACGACUCACUAUAGGGAGGACGAUGCGGACAUAGUAAUGACACGGAGGAUGGAGAAAAAACAGCCAUCUCUUGACGGUUCGGGCGAGUCGUCUG,IMEIRTVAVGIVAIKGVESEYYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHSGGEMFVALNQKGLPVKGKKTKKEQKTAHFLPMAIT,negative +CGGACGAAATTCGTCCCTGTGTG,MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA,negative +CTTCTGCCCGCCTCCTTCCTGGTAAAGTCATTAATAGGTGTGGGGTGCCGGGCATTTCGGAGACGAGATAGGCGGACACT,MVMGLGVLLLVFVLGLGLTPPTLAQDNSRYTHFLTQHYDAKPQGRDDRYCESIMRRRGLTSPCKDINTFIHGNKRSIKAICENKNGNPHRENLRISKSSFQVTTCKLHGGSPWPPCQYRATAGFRNVVVACENGLPVHLDQSIFRRP,negative +CTTGGATCACCATAGTCGCTAGTCGAGGCT,MEKLLCFLVLTSLSHAFGQTDMSRKAFVFPKESDTSYVSLKAPLTKPLKAFTVCLHFYTELSSTRGYSIFSYATKRQDNEILIFWSKDIGYSFTVGGSEILFEVPEVTVAPVHICTSWESASGIVEFWVDGKPRVRKSLKKGYTVGAEASIILGQEQDSFGGNFEGSQSLVGDIGNVNMWDFVLSPDEINTIYLGGPFSPNVLNWRALKYEVQGEVFTKPQLWP,negative +GAGGCUGAUGGCAGACGCCGGCCGAAGACA,MCLSEGIMCSIPPYLQFVFRYPLKSYSFGTKEPNYERDRSVPARFQRLQEDFEKYGMRRSVEGILLVHEHNLPHVLLLQLGTFFKLPGGELHPGEEEIEGLKRLLSEMLGRTDGIPVDWIPEDCIGNWWRPNFEPPRYPYIPAHVTKPKEQTRLFLIQLPEKTLFAVPSNYKLVAAPLFELFDNARAYGPIISSLPQVLSRFNFAYND,negative +CGTACCAAGATCCCACAACTAGCCGACCACAATTGCCGGC,MAAKVASTSSEEAEGSLVTEGEMGEKALPVVYKRYICSFADCGAAYNKNWKLQAHLCKHTGEKPFPCKEEGCEKGFTSLHHLTRHSLTHTGEKNFTCDSDGCDLRFTTKANMKKHFNRFHNIKICVYVCHFENCGKAFKKHNQLKVHQFSHTQQLPYECPHEGCDKRFSLPSRLKRHEKVHAGYPCKKDDSCSFVGKTWTLYLKHVAECHQDLAVCDVCNRKFRHKDYLRDHQKTHEKERTVYLCPRDGCDRSYTTAFNLRSHIQSFHEEQRPFVCEHAGCGKCFAMKKSLERHSVVHDPEKRKLKEKCPRPKRSLASRLTGYIPPKSKEKNASVSGTEKTDSLVKNKPSGTETNGSLVLDKLTIQ,negative +TCCCTACGGCGCTAACCAGTGCTAGCCACTGCGGGGTTCCCTTGTTGCCACCGTGCTACAAC,MGLLGILCFLIFLGKTWGQEQTYVISAPKIFRVGASENIVIQVYGYTEAFDATISIKSYPDKKFSYSSGHVHLSSENKFQNSAILTIQPKQLPGGQNPVSYVYLEVVSKHFSKSKRMPITYDNGFLFIHTDKPVYTPDQSVKVRVYSLNDDLKPAKRETVLTFIDPEGSEVDMVEEIDHIGIISFPDFKIPSNPRYGMWTIKAKYKEDFSTTGTAYFEVKEYVLPHFSVSIEPEYNFIGYKNFKNFEITIKARYFYNKVVTEADVYITFGIREDLKDDQKEMMQTAMQNTMLINGIAQVTFDSETAVKELSYYSLEDLNNKYLYIAVTVIESTGGFSEEAEIPGIKYVLSPYKLNLVATPLFLKPGIPYPIKVQVKDSLDQLVGGVPVTLNAQTIDVNQETSDLDPSKSVTRVDDGVASFVLNLPSGVTVLEFNVKTDAPDLPEENQAREGYRAIAYSSLSQSYLYIDWTDNHKALLVGEHLNIIVTPKSPYIDKITHYNYLILSKGKIIHFGTREKFSDASYQSINIPVTQNMVPSSRLLVYYIVTGEQTAELVSDSVWLNIEEKCGNQLQVHLSPDADAYSPGQTVSLNMATGMDSWVALAAVDSAVYGVQRGAKKPLERVFQFLEKSDLGCGAGGGLNNANVFHLAGLTFLTNANADDSQENDEPCKEILRPRRTLQKKIEEIAAKYKHSVVKKCCYDGACVNNDETCEQRAARISLGPRCIKAFTECCVVASQLRANISHKDMQLGRLHMKTLLPVSKPEIRSYFPESWLWEVHLVPRRKQLQFALPDSLTTWEIQGVGISNTGICVADTVKAKVFKDVFLEMNIPYSVVRGEQIQLKGTVYNYRTSGMQFCVKMSAVEGICTSESPVIDHQGTKSSKCVRQKVEGSSSHLVTFTVLPLEIGLHNINFSLETWFGKEILVKTLRVVPEGVKRESYSGVTLDPRGIYGTISRRKEFPYRIPLDLVPKTEIKRILSVKGLLVGEILSAVLSQEGINILTHLPKGSAEAELMSVVPVFYVFHYLETGNHWNIFHSDPLIEKQKLKKKLKEGMLSIMSYRNADYSYSVWKGGSASTWLTAFALRVLGQVNKYVEQNQNSICNSLLWLVENYQLDNGSFKENSQYQPIKLQGTLPVEARENSLYLTAFTVIGIRKAFDICPLVKIDTALIKADNFLLENTLPAQSTFTLAISAYALSLGDKTHPQFRSIVSALKREALVKGNPPIYRFWKDNLQHKDSSVPNTGTARMVETTAYALLTSLNLKDINYVNPVIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVKQLRLSMDIDVSYKHKGALHNYKMTDKNFLGRPVEVLLNDDLIVSTGFGSGLATVHVTTVVHKTSTSEEVCSFYLKIDTQDIEASHYRGYGNSDYKRIVACASYKPSREESSSGSSHAVMDISLPTGISANEEDLKALVEGVDQLFTDYQIKDGHVILQLNSIPSSDFLCVRFRIFELFEVGFLSPATFTVYEYHRPDKQCTMFYSTSNIKIQKVCEGAACKCVEADCGQMQEELDLTISAETRKQTACKPEIAYAYKVSITSITVENVFVKYKATLLDIYKTGEAVAEKDSEITFIKKVTCTNAELVKGRQYLIMGKEALQIKYNFSFRYIYPLDSLTWIEYWPRDTTCSSCQAFLANLDEFAEDIFLNGC,negative +CUCCUCUAGUGAAGGCAGAGAAAGGUCGAUACGGACGGAAUGUGAUGGCC,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +UUUUUUUAAUUUUUGUUUAUUAAUCUUUAUGCUUUUUUCAUUUAUCUAUAAUUUUUAUU,MAWYWWRRRRRRGWWKPRRRRWRRRRARRRGPARRHRARRRIVRHPCNGQTSSGNRVPRSVQAVDPKYVSLQLVWHSWDFRRGLFGQAGIKRMQQESDALTLSPVHRPKRPKRDTQVKEKTPEKDSDSAVQLRRLQPWIHSSQETKDEEEEIPEGPVQEQLLQQLQQQRLLRVQLESIAQEVLKIRRGHSLHPLLSSHA,negative +AGCAAGGGCCACUGCAAAGCACGCGAGCAU,MLDLFADAEPWQEPLAAGAVILRRFAFNAAEQLIRDINDVASQSPFRQMVTPGGYTMSVAMTNCGHLGWTTHRQGYLYSPIDPQTNKPWPAMPQSFHNLCQRAATAAGYPDFQPDACLINRYAPGAKLSLHQDKDEPDLRAPIVSVSLGLPAIFQFGGLKRNDPLKRLLLEHGDVVVWGGESRLFYHGIQPLKAGFHPLTIDCRYNLTFRQAGKKE,negative +GGGAGAAUUCAACUGCCAUCUAGGCAGUAGGAAUACCCCCAUCCAAAGCUCGCUAGGCUGAACACAGUACUACAAGCUUCUGGACUCGGU,MSAPASTTQATGSTTSTTTKTAGATPATASGLFTIPDGDFFSTARAVVASDAVATNEDLSEIEAVWKDMKVPTDTMAQAAWDLVRHCADVGSSAQTEMIDTGPYSNGISRARLAAAIKEVCTLRQFCMKYAPVVWNWMLTNNSPPANWQAQGFKPEHKFAAFDFFNGVTNPAAIMPKEGLIRPPSEAEMNAAQTAAFVKITKARAQSNDFASLDAAVTRGRITGTTTAEAVVTLPPP,negative +GGGAGGACGATGCGGAGTTTCTTCTGAGGTCTGAACCTTTCGAAAGCTGGCGCTCAGACGACTCGCCCGA,MPSKKNGRSGPQPHKRWVFTLNNPSEDERKKIRELPISLFDYFIVGEEGNEEGRTPHLQGFANFVKKQTFNKVKWYLGARCHIEKAKGTDQQNKEYCSKEGNLLMECGAPRSQGQRSDLSTAVSTLLESGSLVTVAEQHPVTFVRNFRGLAELLKVSGKMQKRDWKTNVHVIVGPPGCGKSKWAANFADPETTYWKPPRNKWWDGYHGEEVVVIDDFYGWLPWDDLLRLCDRYPLTVETKGGTVPFLARSILITSNQTPLEWYSSAAVPAVEALYRRITSLVFWKNATEQSTEEGGQFVTLSPPCPEFPYEINY,negative +ACTCCATTCGTCTCGCGAGCGCAGTGACTCTGGACATTAT,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,negative +UGGGGUAUCGCCAAAAGAAAGGCACCGGAUUCUGAUUCCGGAGGUCGAGAUUGUCGUCCUCGUACCCCAGCCA,SHGGLPCQNSQRGKRSFPAVEICKYKGPARIVVSLVTNEDTPRPHAHSLVGKHCKDGLCTVQVGPNDMTASFPNLGILHVTRKDVVPTLKTRILAQHRLYKDLINNSGGEGQWMEPSDQEIEKKAKEMAKDMDLSVVRLCFQTYLPDVKGHFTQPLEPVISVPVFDSKAPNATTLKICRMDKSAGCCTGGEEVYLLCDKVQKEVIQVKFFEVST,negative +GGGTAACCTTGAGTCACGAATTCAAGCGGGACAGGAGAAACACGGCATGTCAGCGAAGGTACCCAACTTACAGCTTCT,MAWYWWRRRRRRGWWKPRRRRWRRRRARRRGPARRHRARRRIVRHPCNGQTSSGNRVPRSVQAVDPKYVSLQLVWHSWDFRRGLFGQAGIKRMQQESDALTLSPVHRPKRPKRDTQVKEKTPEKDSDSAVQLRRLQPWIHSSQETKDEEEEIPEGPVQEQLLQQLQQQRLLRVQLESIAQEVLKIRRGHSLHPLLSSHA,negative +TCGAATAGCCCCCCGCGTCCGTCTTCCTTTAGCGATCTATGCTCCTTTGTATGGTCGGGC,MGVHECPAWLWLLLSLLSLPLGLPVLGAPPRLICDSRVLERYLLEAKEAENITTGCAEHCSLNENITVPDTKVNFYAWKRMEVGQQAVEVWQGLALLSEAVLRGQALLVNSSQPWEPLQLHVDKAVSGLRSLTTLLRALGAQKEAISPPDAASAAPLRTITADTFRKLFRVYSNFLRGKLKLYTGEACRTGDR,negative +CUCCUCUAGUGAAGGCAGAGAAAGGUCGAUACGGACGGAAUGUGAUGGCC,MLSWGYFLFLLPTLPGAQSQVQLVESGGDVRKPGDSLRLSCKGSGFTFSNYWLGWVRQAPGKALNGSLPLTPLAAAPTYIPGVSGRFTISRDNARALLHLDMSDLRPEDTGRYHCER,negative +AUCGCCCUGAACCGGCCCAGCAGACUGCUGACGGCACGAU,MTSHYVIAIFALMSSCLATAGPEPGALCELSPVSASHPVQALMESFTVLSGCASRGTTGLPQEVHVLNLRTAGQGPGQLQREVTLHLNPISSVHIHHKSVVFLLNSPHPLVWHLKTERLATGVSRLFLVSEGSVVQFSSANFSLTAETEERNFPHGNEHLLNWARKEYGAVTSFTELKIARNIYIKVGEDQVFPPKCNIGKNFLSLNYLAEYLQPKAAEGCVMSSQPQNEEVHIIELITPNSNPYSAFQVDITIDIRPSQEDLEVVKNLILILKCKKSVNWVIKSFDVKGSLKIIAPNSIGFGKESERSMTMTKSIRDDIPSTQGNLVKWALDNGYSPITSYTMAPVANRFHLRLENNAEEMGDEEVHTIPPELRILLDPGALPALQNPPIRGGEGQNGGLPFPFPDISRRVWNEEGEDGLPRPKDPVIPSIQLFPGLREPEEVQGSVDIALSVKCDNEKMIVAVEKDSFQASGYSGMDVTLLDPTCKAKMNGTHFVLESPLNGCGTRPRWSALDGVVYYNSIVIQVPALGDSSGWPDGYEDLESGDNGFPGDMDEGDASLFTRPEIVVFNCSLQQVRNPSSFQEQPHGNITFNMELYNTDLFLVPSQGVFSVPENGHVYVEVSVTKAEQELGFAIQTCFISPYSNPDRMSHYTIIENICPKDESVKFYSPKRVHFPIPQADMDKKRFSFVFKPVFNTSLLFLQCELTLCTKMEKHPQKLPKCVPPDEACTSLDASIIWAMMQNKKTFTKPLAVIHHEAESKEKGPSMKEPNPISPPIFHGLDTLTVMGIAFAAFVIGALLTGALWYIYSHTGETAGRQQVPTSPPASENSSAAHSIGSTQSTPCSSSSTA,negative +UUAACCAUCAGCUCAUGGCCCCUGCCCUCUCAAGGACCAC,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,negative +TTACCGTGATGTATGATATGCATCCACCGTG,WPLTEEKIKALVEICXEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEEFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDXIIYQYMDDLYVGSDLEIGQHRTKVEELRQHLLXWGFTTPDKKHQKEPPFLWMGYELHP,negative +GGGAGCTCAGAATAAACGCTCAAGAAGGTGGGAGGGTGGGGTGGTTGAAGAATGTTCGACATGAGGCCCGGATC,MAWYWWRRRRRRGWWKPRRRRWRRRRARRRGPARRHRARRRIVRHPCNGQTSSGNRVPRSVQAVDPKYVSLQLVWHSWDFRRGLFGQAGIKRMQQESDALTLSPVHRPKRPKRDTQVKEKTPEKDSDSAVQLRRLQPWIHSSQETKDEEEEIPEGPVQEQLLQQLQQQRLLRVQLESIAQEVLKIRRGHSLHPLLSSHA,negative +CTCCTCTGACTGTAACCACGAGAAATTGGTACTGTATGAAACGGCAGCTGCACGTCGCGGCATAGGTAGTCCAGAAGCC,MPFVNKQFNYKDPVNGVDIAYIKIPNVGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAGHRLYGIAINPNRVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNRKTYLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLKNFTGLFEFYKLLCVRGIITSKTKSLDKGYNKALNDLCIKVNNWDLFFSPSEDNFTNDLNKGEEITSDTNIEAAEENISLDLIQQYYLTFNFDNEPENISIENLSSDIIGQLELMPNIERFPNGKKYELDKYTMFHYLRAQEFEHGKSRIALTNSVNEALLNPSRVYTFFSSDYVKKVNKATEAAMFLGWVEQLVYDFTDETSEVSTTDKIADITIIIPYIGPALNIGNMLYKDDFVGALIFSGAVILLEFIPEIAIPVLGTFALVSYIANKVLTVQTIDNALSKRNEKWDEVYKYIVTNWLAKVNTQIDLIRKKMKEALENQAEATKAIINYQYNQYTEEEKNNINFNIDDLSSKLNESINKAMININKFLNQCSVSYLMNSMIPYGVKRLEDFDASLKDALLKYIYDNRGTLIGQVDRLKDKVNNTLSTDIPFQLSKYVDNQRLLSTFTEYIKNIINTSILNLRYESNHLIDLSRYASKINIGSKVNFDPIDKNQIQLFNLESSKIEVILKNAIVYNSMYENFSTSFWIRIPKYFNSISLNNEYTIINCMENNSGWKVSLNYGEIIWTLQDTQEIKQRVVFKYSQMINISDYINRWIFVTITNNRLNNSKIYINGRLIDQKPISNLGNIHASNNIMFKLDGCRDTHRYIWIKYFNLFDKELNEKEIKDLYDNQSNSGILKDFWGDYLQYDKPYYMLNLYDPNKYVDVNNVGIRGYMYLKGPRGSVMTTNIYLNSSLYRGTKFIIKKYASGNKDNIVRNNDRVYINVVVKNKEYRLATNASQAGVEKILSALEIPDVGNLSQVVVMKSKNDQGITNKCKMNLQDNNGNDIGFIGFHQFNNIAKLVASNWYNRQIERSSRTLGCSWEFIPVDDGWGERPL,negative +GGUGAUCGCACAGACACGGGCACUGAUGCGGCUCCCGUACAUAGGCCGGUAGUACUACAAGCUUCUGGACUCGGU,MKKRKVLIPLMALSTILVSSTGNLEVIQAEVKQENRLLNESESSSQGLLGYYFSDLNFQAPMVVTSSTTGDLSIPSSELENIPSENQYFQSAIWSGFIKVKKSDEYTFATSADNHVTMWVDDQEVINKASNSNKIRLEKGRLYQIKIQYQRENPTEKGLDFKLYWTDSQNKKEVISSDNLQLPELKQKSSNSRKKRSTSAGPTVPDRDNDGIPDSLEVEGYTVDVKNKRTFLSPWISNIHEKKGLTKYKSSPEKWSTASDPYSDFEKVTGRIDKNVSPEARHPLVAAYPIVHVDMENIILSKNEDQSTQNTDSQTRTISKNTSTSRTHTSEVHGNAEVHASFFDIGGSVSAGFSNSNSSTVAIDHSLSLAGERTWAETMGLNTADTARLNANIRYVNTGTAPIYNVLPTTSLVLGKNQTLATIKAKENQLSQILAPNNYYPSKNLAPIALNAQDDFSSTPITMNYNQFLELEKTKQLRLDTDQVYGNIATYNFENGRVRVDTGSNWSEVLPQIQETTARIIFNGKDLNLVERRIAAVNPSDPLETTKPDMTLKEALKIAFGFNEPNGNLQYQGKDITEFDFNFDQQTSQNIKNQLAELNATNIYTVLDKIKLNAKMNILIRDKRFHYDRNNIAVGADESVVKEAHREVINSSTEGLLLNIDKDIRKILSGYIVEIEDTEGLKEVINDRYDMLNISSLRQDGKTFIDFKKYNDKLPLYISNPNYKVNVYAVTKENTIINPSENGDTSTNGIKKILIFSKKGYEIG,negative +CTTTGGAGACAGTCCGTGGTAGGGCAGGTTGGGGTGACTTCGTGGAAGAAGCGAGACGGT,WPLTEEKIKALVEICXEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEEFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDXIIYQYMDDLYVGSDLEIGQHRTKVEELRQHLLXWGFTTPDKKHQKEPPFLWMGYELHP,negative +AAGACGGCCCGGUGUGCAGCCGGAGAUCCGAGACUUGCU,SRWDSTQQRAVLAAAVEIMVKFSSQPHLAQVVAEDLLSPSVMDVGDFKISITEGLPSGVPCTSQWNSIAHWLLTLCALSETTNLSPDIIQANSLFSFYG,negative +TATTAGTACTAATATTAGTACTAA,PHITDVVLDKANKTPLRQLDPSRLPDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFAKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRQSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPINRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDTASEATRPATLNRFSALQQTLPAENTDNRRVVQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRTRTPATKRSFSKEVEERSRERPSQPEGLRKAASLTEDRGRDPVKREATLPPVSPPKAALSVDEVEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRLGIESTLERSTIAREHMGRLLHQLLCAGHLSTAQYYQGLYETLELAEDMEIDIPHVWLYLAELITPILQEDGVPMGELFREITKPLRPMGKATSLLLEILGLLCKSMGPKKVGMLWREAGLSWREFLAEGQDVGSFVAEKKVEYTLGEESEAPGQRTLAFEELRRQLEKLLKDGGSNQRVFDWIDANLNEQQIASNTLVRALMTTVCYSAIIFETPLRVDVQVLKVRARLLQKYLCDEQKELQALYALQALVVTLEQPANLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFNWLREAEDEESDHN,negative +GTTTCCAAAGCCGGGGGGGTGGGATGGGTT,MIPPPRRSASSTPKDYRSSRDLQPWRGVSSGDAAETSQQSRHRRDAIADGGGRLKGAAQSSPSSGTRRSGPYAQGRAMPKNENIPKPGKQRLGPRKKKLSTLKKKILLDRLERWRDKQHEGALSTPSATASSEEAKCNNPFPLCPPGELSPPPSPPATICPAVVDKSTSYGQVGGANGERSVWAITIYNLVDQEDVEDDDDHAEIERDLWDMSSAFGVVRSVQVPRGTAVQVSDAEVSAAAAAGEPAAVAAKVAFATNAEAECARDGLNGRIVGGKPLLVRIHRCDGHFCGGVCPGDPDGSGLWRVAIENLIDEEDDLDDEDEYAEISANVSAMMGCYGKLVDVQVRRSSPSKGEVQEDVATRAATTAGATQAVVVTFGSLAEAEACVQGIKGCRVGGKELDAHVVLDSERVLPSNPAFKCDQEHAHSSDVAAAVAGQGDSMMKQEAGTEPSPCVDQDTAAAVASSTEWRVVIRGLIDEDDLQDDDDDYAEVCSDVTALVSSYGAVVGLDIPRGRETGSCCYGAEPGEAVVVFRSLQEAEACARGLSGRKVAGNILDAQVLTQPAPSQQGPLQGGASGTGPPVANRERKPAKECPLPQHQASSHQSCGKVPELDGSGPGMLRGFGNRVEDCCGRPKIACTDSDEPQAIAAAAPPGQSIEGPKTTALAKAGKRIQTKYQEAAALPKPPGVRGGLPNAYVNQPPDKEVNDLVFEMLQLLFKFQERARLSDPSKAKTRRRLVIGLREVLRGVKAKKVRLLIVAPNVDAVGGEGGLDDKVVEIIDKAREAEYPVVFALSKRKIGKALGKTIKVSAVGVYSFDGANEQQKQLKRRMETISSLPSPSPRQSDPPTDDALASPPSSSACGDSQDPAGKGSRV,negative +CTATAGAGGTGCTCCAGGGCGATAAACTTATGAATATTAA,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +AGCAAGGGCCACUGCAAAGCACGCGAGCAU,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,negative +UUGUAAUGUAUACCGCGCGCCC,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,negative +GUAUAUAGUAUAGUAUUGGC,MHGDTPTLHEYMLDLQPETTDLYCYEQLNDSSEEEDEIDGPAGQAEPDRAHYNIVTFCCKCDSTLRLCVQSTHVDIRTLEDLLMGTLGIVCPICSQKP,negative +UCUACCAGAGCGAGUGUGCUGAACGUUCUAAGGACGGGAUUGAAUCGAGAUGCGUAUACUAGGACCUUAGG,XQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGSTGSPGPGYGYSNYGFPPYGGITFHPGVTKSNAGVTHGTINTKFKNGPKDCAKSDDEESLTLPEKETEGEGPSLPMACTKTEPIALASTMEDKEQDMGFQDNLFLEKALQLARRHANALFDYAVTGDVKMLLAVQRHLTAVQDENGDSVLHLAIIHLHAQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRVGADLSLLDRWGNSVLHLAAKEGHDRILSILLKSRKAAPLIDHPNGEGLNAIHIAVMSNSLPCLLLLVAAGAEVNAQEQKSGRTALHLAVEYDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWEKAGEDEGVVPGTTPLDMAANWQVFDILNGKPYEPVFTSDDILPQGDMKQLTEDTRLQLCKLLEIPDPDKNWATLAQKLGLGILNNAFRLSPAPSKTLMDNYEMNSGIVTASVTVVWRHPSANSALQSLLLETAHCYL,negative +GCTTTACCGCACTTCCGATCTTTAATTTCGAGTGTATCAT,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,negative +CGTTCGAAATTCGAACCTGTGTG,MQLPLALCLVCLLVHTAFRVVEGQGWQAFKNDATEIIPELGEYPEPPPELENNKTMNRAENGGRPPHHPFETKDVSEYSCRELHFTRYVTDGPCRSAKPVTELVCSGQCGPARLLPNAIGRGKWWRPSGPDFRCIPDRYRAQRVQLLCPGGEAPRARKVRLVASCKCKRLTRFHNQSELKDFGTEAARPQKGRKPRPRARSAKANQAELENAY,negative +GGTTGTGAAGATTGGGAGCGTCGTGGCTAC,MCLSEGIMCSIPPYLQFVFRYPLKSYSFGTKEPNYERDRSVPARFQRLQEDFEKYGMRRSVEGILLVHEHNLPHVLLLQLGTFFKLPGGELHPGEEEIEGLKRLLSEMLGRTDGIPVDWIPEDCIGNWWRPNFEPPRYPYIPAHVTKPKEQTRLFLIQLPEKTLFAVPSNYKLVAAPLFELFDNARAYGPIISSLPQVLSRFNFAYND,negative +GGAGCGCAAUUCGCCUCGCAAGUUGAACUCCGCUGGCGG,MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP,negative +AUCGCCCUGAACCGGCCCAGCAGACUGCUGACGGCACGAU,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +GCUAUCAUCAUUAACUUUAUUUAUUACCGUCAUUCAUUUCUGAAUGUCUGUUUACCCCUAUUUCAACCGGUUUUUUUU,MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC,negative +UCGUGU,IMEIRTVAVGIVAIKGVESEYYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHSGGEMFVALNQKGLPVKGKKTKKEQKTAHFLPMAIT,negative +CCCCCCUCCAAAGACCCGCCAUAUCGCCCC,MPSNQEARLFLAVLVLAQVLPILVDSAAEKGFKQAFWQPLCQVSEELDDQPKGALFTLQAAASKIQKMRDAALRASIYAEINHGTNRAKAAVIVANHYAMKADSGLEALKQTLSSQEVTATATASYLKGRIDEYLNLLLQTKESGTSGCMMDTSGTNTVTKAGGTIGGVPCKLQLSPIQPKRPAATYLGKAGYVGLTRQADAANNFHDNDAECRLASGHNTNGLGKSGQLSAAVTMAAGYVTVANSQTAVTVQALDALQEASGAAHQPWIDAWKAKKALTGAETAEFRNETAGIAGKTGVTKLVEEALLKKKDSEASEIQTELKKYFSGHENEQWTAIEKLISEQPVAQNLVGDNQPTKLGELEGNAKLTTILAYYRMETAGKFEVLTQKHKPAESQQQAAETEGSCNKKDQNECKSPCKWHNDAENKKCTLDKEEAKKVADETAKDGKTGNTNTTGSSNSFVISKTPLWLAVLLF,negative +TATTAGCAACAATATTAGCAACAA,MSMSPKHTTPFSVSDILSPLEESYKKVGMEGGGLGAPLAAYRQGQAAPPAAAMQQHAVGHHGAVTAAYHMTAAGVPQLSHSAVGGYCNGNLGNMSELPPYQDTMRNSASGPGWYGANPDPRFPAISRFMGPASGMNMSGMGGLGSLGDVSKNMAPLPSAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGGGGGGGAGCPQQQQAQQQSPRRVAVPVLVKDGKPCQAGAPAPGAGSLQGHAQQQAQQQAQAAQAAAAAISVGSGGPGLGAHPGHQPGSAGQSPDLAHHAASPAALQGQVSSLSHLNSSGSDYGTMSCSTLLYGRTW,negative +CTTGCAAAATTTGCAACTGTGTG,MLSWGYFLFLLPTLPGAQSQVQLVESGGDVRKPGDSLRLSCKGSGFTFSNYWLGWVRQAPGKALNGSLPLTPLAAAPTYIPGVSGRFTISRDNARALLHLDMSDLRPEDTGRYHCER,negative +AGCTTAGTGCATATCACTCCTCGTTATAGCATGGTTATAG,MAIPKELLVLLLGIAILSKVAECAAFGSRRGLVETVFDVTRFGARPNTPADSTRGLMMAWRSACQSPGPAKVVIPPGTYTTGETIFQGPCTSPRPITIEIQGTLLSNTDMSLYTRAAWISIEHVDGIVITGGGTLNGQGKSSWQFADKSGSTPPLPSSLVFQTVRSSSIKNLNFVDAKGVHLKITDSSDISVSNIKITAPGDSPNTDGLHISDTINVNVTDSTIGTGDDCISIGDGNSNVYISNINCGPGHGISIGSLGKRLDETDVKGVTVRNCTFRGTTNGARIKTYMGSPSLQVSGVVYEDIILDNVKNPIVIDQHYHSKNRNEPSRVKLVDIHFRNIRGTTTSKIPVLLNCSEALPCEGVELVDIDLAPVGSIGPLLPATCQNAKTILNGKNNPPAC,negative +ACTCCAACGATCCCACCGCGACAAGGGTCATCGGCACCGT,MSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA,negative +GGGCGAAUUCGAGCCUCAAGACGUCGGGGAUUGGCAAACCCCGUUUCCUUGAGCGACCCCCUGUUACUCGGCGGAUCCUCU,MSARGEEAAGEASGSQEQPEPALAEPKKRGPGRPRKPQQEPTGEPVPKRPRGRPKGSKNKGPSKAAQKKAETTGEKRPRGRPRKWPQQVVQEKPAQEEEEEEEEEEAEED,negative +CGGTCGCTCCGTGTGGCTTGGGTTGGGTGTGGCAGTGAC,MSSTESPVPAAAAPAEAVPASTPAPAAEQPAVGNGEQRNNADAANNTSLYVGELDPSVTEAMLFEIFSMIGTVASIRVCRDAVTRRSLGYAYVNFLNAADGERAMEQLNYSLIRNRPCRIMWSQRDPALRRTGQGNIFIKNLDAGIDNKALHDTFAAFGNILSCKVATNETGSLGYGFVHYETAEAAEAAIKHVNGMLLNDKKVYVGHHIPRKERQAKIEETRANFTNVYAKNVDPEVTDDEFEKLFTKFGKITSCVLQRDEDGKSKGFGFVNFEDHNEAQKAVDELHDSDFKGQKLFVARAQKKSEREEELRRSYEAAKNEKLAKFQGVNLYLKNIPESYDDERLREEFAPFGAITSCKIMRAPSGVSRGFGFVCYSAPEEANKAVSEMNGKMLDNRPLYVALAQRKDVRRQQLEAQIMQRNQLRLQQQAAAQGMGYPGPGMYYPQPGAFPGQPGGMVPRPRYAPAGMMPQGMPMAPYGQPGQFPAGMMPQGYRPARPPRGAPNAAGGPAPPAGARPPTGVNGAPRPAGQPVPGQPMPRGPAARPAGRPEADQPGALTAAALAKASPEEQKQMLGEAIYPKVAASQPELAGKLTGMILELPVTELLHLLEESEALDAKVNEALEVLKEYQQNDSAGAEAEANAEAPKTEA,negative +CUCAGAGACAGAGCAGAAACGACAGUUCAAGCCGAA,VENLMVQELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFSHFRLFDENNDAAILILLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVN,negative +GGUCCGUAGUUCUGGCUGACUGGUUACCCGGUCGUACAGCUCG,PHITDVVLDKANKTPLRQLDPSRLPDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFAKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRQSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPINRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDTASEATRPATLNRFSALQQTLPAENTDNRRVVQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRTRTPATKRSFSKEVEERSRERPSQPEGLRKAASLTEDRGRDPVKREATLPPVSPPKAALSVDEVEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRLGIESTLERSTIAREHMGRLLHQLLCAGHLSTAQYYQGLYETLELAEDMEIDIPHVWLYLAELITPILQEDGVPMGELFREITKPLRPMGKATSLLLEILGLLCKSMGPKKVGMLWREAGLSWREFLAEGQDVGSFVAEKKVEYTLGEESEAPGQRTLAFEELRRQLEKLLKDGGSNQRVFDWIDANLNEQQIASNTLVRALMTTVCYSAIIFETPLRVDVQVLKVRARLLQKYLCDEQKELQALYALQALVVTLEQPANLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFNWLREAEDEESDHN,negative +AGCAAGGGCCACUGCAAAGCACGCGAGCAU,MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPGPHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR,negative +ATATTTATATTTATT,MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPGPHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR,negative +ACACCCUCAACAAGUCCCGCCAACAACGC,MTRCTADNSLTNPAYRRRTMATGEMKEFLGIKGTEPTDFGINSDAQDLPSPSRQASTRRMSIGESIDGKINDWEEPRLDIEGFVVDYFTHRIRQNGMEWFGAPGLPCGVQPEHEMMRVMGTIFEKKHAENFETFCEQLLAVPRISFSLYQDVVRTVGNAQTDQCPMSYGRLIGLISFGGFVAAKMMESVELQGQVRNLFVYTSLFIKTRIRNNWKEHNRSWDDFMTLGKQMKEDYERAEAEKVGRRKQNRRWSMIGAGVTAGAIGIVGVVVCGRMMFSLK,negative +TATATATATATATAT,MSDNGPQSNQRSAPRITFGGPTDSTDNNQNGGRNGARPKQRRPQGLPNNTASWFTALTQHGKEELRFPRGQGVPINTNSGPDDQIGYYRRATRRVRGGDGKMKELSPRWYFYYLGTGPEASLPYGANKEGIVWVATEGALNTPKDHIGTRNPNNNAATVLQLPQGTTLPKGFYAEGSRGGSQASSRSSSRSRGNSRNSTPGSSRGNSPARMASGGGETALALLLLDRLNQLESKVSGKGQQQQGQTVTKKSAAEASKKPRQKRTATKQYNVTQAFGRRGPEQTQGNFGDQDLIRQGTDYKHWPQIAQFAPSASAFFGMSRIGMEVTPSGTWLTYHGAIKLDDKDPQFKDNVILLNKHIDAYKTFPPTEPKKDKKKKTDEAQPLPQRQKKQPTVTLLPAADMDDFSRQLQNSMSGASADSTQA,negative +CACCUACCUAAUUAUUAAACUUUGGGCAGUAUCCCGCUUUGCUUCUUAUC,MAGPQALAFGLLLAVVTATLAAAQRDCVCDNYKLATSCSLNEYGECQCTSYGTQNTVICSKLASKCLAMKAEMTHSKSGRRIKPEGAIQNNDGLYDPDCDEQGLFKAKQCNGTATCWCVNTAGVRRTDKDTEITCSERVRTYWIIIELKHKERESPYDHQSLQTALQEAFTSRYKLNQKFIKNIMYENNVITIDLMQNSSQKTQDDVDIADVAYYFEKDVKGESLFHSSKSMDLRVNGEPLDLDPGQTLIYYVDEKAPEFSMQGLTAGIIAVIVVVSLAVIAGIVVLVISTRKKSAKYEKAEIKEMGEIHRELNA,negative +TAGGGAATTTCGACGGATCCAGCUGAUGUGGGACGUCAGUUAUAGGAAUGUGGAGGUUGGAAGUUAUGGCUUGCAUCAGCTGCAGGTCGACGCATGCGCCG,MSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA,negative +CGGTCGAAATTCGACCCTGTGTG,MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYTFLLPEMDNCRSSSSPYVSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQDNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVLVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF,negative +GAGACGGCCAGCCAAGGCGCUGAGAUCCGAGGUUUCAG,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +GGGCGAAUUCAACUGCCAUCUAGGCAGUAACCAGGAGUUAGUAGGACAAGUUUCGUCC,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,negative +AGUUUCAUCGUCCGAGCAAGAUCCUAAUGGCGUCCGGCGCGUUUAUGACU,MQRTKEAVKASDGNLLGDPGRIPLSKRESIKWQRPRFTRQALMRCCLIKWILSSAAPQGSDSSDSELELSTVRHQPEGLDQLQAQTKFTKKELQSLYRGFKNECPTGLVDEDTFKLIYSQFFPQGDATTYAHFLFNAFDADGNGAIHFEDFVVGLSILLRGTVHEKLKWAFNLYDINKDGCITKEEMLAIMKSIYDMMGRHTYPILREDAPLEHVERFFQKMDRNQDGVVTIDEFLETCQKDENIMNSMQLFENVI,negative +TCCCACGCATTCTCCACATCCGCACGAGCATCGTACTTCCGTTATGATCATGAGACACAGCCTTTCTGTCCTTCCGTCAC,MVMGLGVLLLVFVLGLGLTPPTLAQDNSRYTHFLTQHYDAKPQGRDDRYCESIMRRRGLTSPCKDINTFIHGNKRSIKAICENKNGNPHRENLRISKSSFQVTTCKLHGGSPWPPCQYRATAGFRNVVVACENGLPVHLDQSIFRRP,negative +GGCGACCCCCGGGCTACCAGACAATGTACGCAGCAAGAGTGACGGTCGTACCTCGGAGTC,MSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA,negative +UCAAUCGGCGCUUUACUCUUGCGCUCACCGUGCCC,MSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEMLDRHHTHFCPLEGESWQDFLRNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAFLCQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERETPTTDSMPPLLRQAIELFDHQGAEPAFLFGLELIICGLEKQLKCESGS,negative +GGUGAUCGCACAGACACGGGCACUGAUGCGGCUCCCGUACAUAGGCCGGUAGUACUACAAGCUUCUGGACUCGGU,VFTDNSSPPAVPQSFQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGFGAYMSKAHGVDPNIRTGVRTITTGSPITYSTYGKFLADGGCSGGAYDIIICDECHSTDATSILGIGTVLDQAETAGARLVVLATATPPGSVTVSHPNIEEVALSTTGEIPFYGKAIPLEVIKGGRHLIFCHSKKKCDELAAKLVALGINAVAYYRGLDVSVIPTSGDVVVVSTDALMTGFTGDFDSVIDCNTCVTQTVDFSLDPTFTIETTTLPQDAVSRTQRRGRTGRGKPGIYRFVAPGERPSGMFDSSVLCECYDAGCAWYELTPAETTVRLRAYMNTPGLPVCQDHLEFWEGVFTGLTHIDAHFLSQTKQSGENFPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPTLHGPTPLLYRLGAVQNEVT,negative +GGATGATGCCGCACTGACGCCACGTAGGTGGCGCACAGCC,MSSTESPVPAAAAPAEAVPASTPAPAAEQPAVGNGEQRNNADAANNTSLYVGELDPSVTEAMLFEIFSMIGTVASIRVCRDAVTRRSLGYAYVNFLNAADGERAMEQLNYSLIRNRPCRIMWSQRDPALRRTGQGNIFIKNLDAGIDNKALHDTFAAFGNILSCKVATNETGSLGYGFVHYETAEAAEAAIKHVNGMLLNDKKVYVGHHIPRKERQAKIEETRANFTNVYAKNVDPEVTDDEFEKLFTKFGKITSCVLQRDEDGKSKGFGFVNFEDHNEAQKAVDELHDSDFKGQKLFVARAQKKSEREEELRRSYEAAKNEKLAKFQGVNLYLKNIPESYDDERLREEFAPFGAITSCKIMRAPSGVSRGFGFVCYSAPEEANKAVSEMNGKMLDNRPLYVALAQRKDVRRQQLEAQIMQRNQLRLQQQAAAQGMGYPGPGMYYPQPGAFPGQPGGMVPRPRYAPAGMMPQGMPMAPYGQPGQFPAGMMPQGYRPARPPRGAPNAAGGPAPPAGARPPTGVNGAPRPAGQPVPGQPMPRGPAARPAGRPEADQPGALTAAALAKASPEEQKQMLGEAIYPKVAASQPELAGKLTGMILELPVTELLHLLEESEALDAKVNEALEVLKEYQQNDSAGAEAEANAEAPKTEA,negative +GGGCGCUUAAUGUAUGCCGUAUGACCCUCAACAUCCGACUCAGUUAAGC,MEYASDASLDPEAPWPPAPRARACRVLPWALVAGLLLLLLLAAACAVFLACPWAVSGARASPGSAASPRLREGPELSPDDPAGLLDLRQGMFAQLVAQNVLLIDGPLSWYSDPGLAGVSLTGGLSYKEDTKELVVAKAGVYYVFFQLELRRVVAGEGSGSVSLALHLQPLRSAAGAAALALTVDLPPASSEARNSAFGFQGRLLHLSAGQRLGVHLHTEARARHAWQLTQGATVLGLFRVTPEIPAGLPSPRSE,negative +TACGACCAATACGCCCAATACTGCTCCGACTGCTGCATTATCCAC,MSPQRDRINAFYKDNPHPKGSRIVINREHLMIDRPYVLLAVLFVMFLSLIGLLAIAGIRLHRAAIYTAEIHKSLSTNLDVTNSIEHQVKDVLTPLFKIIGDEVGLRTPQRFTDLVKFISDKIKFLNPDREYDFRDLTWCINPPERIKLDYDQYCADVAAEELMNALVNSTLLEARATNQFLAVSKGNCSGPTTIRGQFSNMSLSLLDLYLSRGYNVSSIVTMTSQGMYGGTYLVEKPNLSSKGSELSQLSMHRVFEVGVIRNPGLGAPVFHMTNYFEQPVSNDFSNCMVALGELKFAALCHREDSITIPYQGSGKDVSFQLVKLGVWKSPTDMQSWVPLSTDDPVIDRLYLSSHRGVIADNQAKWAVPTTRTDDKLRMETCFQQACKGKIQALCENPDWAPLKDNRIPSYGVLSVNLSLTVELKIKIASGFGPLITHGSGMDLYKSNHNNMYWLTIPPMKNLALGVINTLEWIPRFRVSPNLFTVPIKEAGEDCHAPTYLPAEVDGDVKLSSNLVILPGQDLQYVLATYDTSRVEHAVVYYVYSPSRSFSYFYPFRLPIKGVPIELQVECFTWDQKLWCRHFCVLADSGSGGHITHSGMVGMGVSCTVTREDGTNRR,negative +UGUUGUUGGACCAGUGUUAUUUUACGCGAUUGUGCGGUUGUGA,SRWDSTQQRAVLAAAVEIMVKFSSQPHLAQVVAEDLLSPSVMDVGDFKISITEGLPSGVPCTSQWNSIAHWLLTLCALSETTNLSPDIIQANSLFSFYG,negative +CAGCGGGCATTTCTAGGGCCATCTTTAATCTTCTTTATGGAGAGCCTCGTTCACACGTTG,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,negative +CCAGAUUGUCCCCCACCAGAAGUGCAAUGC,MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICEVEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASSIVYKKEGEQVEFSFPLAFTVEKLTGSGELWWQAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLPQALPQYAGSGNLTLALEAKTGKLHQEVNLVVMRATQLQKNLTCEVWGPTSPKLMLSLKLENKEAKVSKREKAVWVLNPEAGMWQCLLSDSGQVLLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQAERMSQIKRLLSEKKTCQCPHRFQKTCSPI,negative +CGGGGGTGCCCGCTGCTCGTCCAAATGACGGCTCAGCTTCGGTGGGCCTTTAACAGTAATCAATCATATGAGCAGTTTTCAACGATCACCTACCCACACCGCTCGAATGTTTGCATAAACCTGGGTAGACTCACGCATAATTGGGTTATTGAGTCTCTTTGATGGACTAACCCGGTTCTATCTCGGAGGTATTTTAGGTC,MHGDTPTLHEYMLDLQPETTDLYCYEQLNDSSEEEDEIDGPAGQAEPDRAHYNIVTFCCKCDSTLRLCVQSTHVDIRTLEDLLMGTLGIVCPICSQKP,negative +TATTAATAATAATATTAATAATAA,MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC,negative +AACAUAUCCCCAGCCAUGCAACGUGGCGAA,MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPGPHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR,negative +CGGTCGCTCCGTGTGGCTTGGGTTGGGTGTGGCAGTGAC,MGVLLTQRTLLSLVLALLFPSMASMAAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQGLDVPKLREHCRERPGAFPSEETLRGLGRRGFLQTLNATLGCVLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILGLRNNIYCMAQLLDNSDTAEPTKAGRGASQPPTPTPASDAFQRKLEGCRFLHGYHRFMHSVGRVFSKWGESPNRSRRHSPHQALRKGVRRTRPSRKGKRLMTRGQLPR,negative +CTTCTGCCCGCCTCCTTCCGATTGAAAGGTCTGTTTTTGGGGTTGGTTTGGGTCAATAGGAGACGAGATAGGCGGACACT,MLDLFADAEPWQEPLAAGAVILRRFAFNAAEQLIRDINDVASQSPFRQMVTPGGYTMSVAMTNCGHLGWTTHRQGYLYSPIDPQTNKPWPAMPQSFHNLCQRAATAAGYPDFQPDACLINRYAPGAKLSLHQDKDEPDLRAPIVSVSLGLPAIFQFGGLKRNDPLKRLLLEHGDVVVWGGESRLFYHGIQPLKAGFHPLTIDCRYNLTFRQAGKKE,negative +AACAUAUCCCCAGCCAUGCAACGUGGCGAA,MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC,negative +UCGGACCGGCAAUAAGGGUAUGGCCGUAUAAUCCAGGUCGCCGCUGUCCGA,MTRCTADNSLTNPAYRRRTMATGEMKEFLGIKGTEPTDFGINSDAQDLPSPSRQASTRRMSIGESIDGKINDWEEPRLDIEGFVVDYFTHRIRQNGMEWFGAPGLPCGVQPEHEMMRVMGTIFEKKHAENFETFCEQLLAVPRISFSLYQDVVRTVGNAQTDQCPMSYGRLIGLISFGGFVAAKMMESVELQGQVRNLFVYTSLFIKTRIRNNWKEHNRSWDDFMTLGKQMKEDYERAEAEKVGRRKQNRRWSMIGAGVTAGAIGIVGVVVCGRMMFSLK,negative +GAGCGGUUAAGGGAGAUUUAGGCAGCAGCUUGGACAGUGUAUCGGCUGAG,MGVLLTQRTLLSLVLALLFPSMASMAAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQGLDVPKLREHCRERPGAFPSEETLRGLGRRGFLQTLNATLGCVLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILGLRNNIYCMAQLLDNSDTAEPTKAGRGASQPPTPTPASDAFQRKLEGCRFLHGYHRFMHSVGRVFSKWGESPNRSRRHSPHQALRKGVRRTRPSRKGKRLMTRGQLPR,negative +TATTAGTAATCATATTAGTAATCA,MAVAQELYGFPASKLDSFVAQWLQPTREWKEEVLETVQTVEQFLRQENFREDRGPARDVRVLKVLKVGCFGNGTVLRSTTDVELVVFLSCFHSFQEEAKHHQAVLRLIQKRMYYCQELMDLGLSNLSVTNRVPSSLIFTIQTRETWETITVTVVPAYRALGPSCPSSEVYANLIKANGYPGNFSPSFSELQRNFVKHRPTKLKSLLRLVKHWYQQYVRDKCPRANLPPLYALELLTVYAWEAGTREDANFRLDEGLATVMELLQDHELLCIYWTKHYTLQHPVIEACVRRQLRGQRPIILDPADPTNNVAEGYRWDIVAQRANQCLKQDCCYDNRDSPVPSWRVKRAPDIQVTVQEWGHSDLTFWVNPYEPIKKLKEKIQLSQGYLGLQRLSFQEPGGERQLIRSHCTLAYYGIFCDTHICLLDTISPEIQVFVKNPDGRSHAYAIHPLDYVLNLKQQIEDRQGLRCQEQRLEFQGHILEDWFDFKSYGIQDSVTVILSKTTEGAAPFVPS,negative +CTACTGAATTTGGCTTTATAAGGGTTACGACCGTCCTCGT,MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC,negative +UCAAGAAUUCCGUUUUCAGUCGGGAAAAACUGAACAA,MRKIVVAAIAVSLTTVSITASASADPSKDSKAQVSAAEAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKVKPSAASIDAAKKAGVNNGNPLDAVQQ,negative +CGCACTGAAGTGGGATACCGCCTAAACGG,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +UAUGUUGUGUGUGUGUUGUUUUUGUGUUUUGUUUU,MAGRSGDSDEELLKAVRLIKFLYQSNPPPNPEGTRQARRNRRRRWRERQRQIHSISERILSTYLGRSAEPVPLQLPPLERLTLDCNEDCGTSGTQGVGSPQILVESPTILESGAKE,negative +GGGAGCTCAGAATAAACGCTCAACATGGATGGGAGGGTGGGGCTGGGTTGTAGAATATTCGACATGAGGCCCGGATC,XQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGSTGSPGPGYGYSNYGFPPYGGITFHPGVTKSNAGVTHGTINTKFKNGPKDCAKSDDEESLTLPEKETEGEGPSLPMACTKTEPIALASTMEDKEQDMGFQDNLFLEKALQLARRHANALFDYAVTGDVKMLLAVQRHLTAVQDENGDSVLHLAIIHLHAQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRVGADLSLLDRWGNSVLHLAAKEGHDRILSILLKSRKAAPLIDHPNGEGLNAIHIAVMSNSLPCLLLLVAAGAEVNAQEQKSGRTALHLAVEYDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWEKAGEDEGVVPGTTPLDMAANWQVFDILNGKPYEPVFTSDDILPQGDMKQLTEDTRLQLCKLLEIPDPDKNWATLAQKLGLGILNNAFRLSPAPSKTLMDNYEMNSGIVTASVTVVWRHPSANSALQSLLLETAHCYL,negative +GUGGUGAAGAGGUACCGGAAUUGCUAAAGAUACCACGGCC,MPEEWVRIFGEAGITQFEQQRNPRLCLSVLNILSKSEHPQEKFMFVPYEQSALPVTDNSPFGDTSITHNYADHHFKASTPENEGSSFYSRVPGPCTVGVRSSSLSSGRGSSEGVGSRSGSGSGGAASRSSSSGHGGAGFPLPVTSVPANGRSSAPGPNSMTVTSGSHSSSGSNCSTGSLTGGMELTNTMVATTQRTGPNNVLVNGHSTGNHFHGGVTQRVAASAAPTECNVLPTYTGSSSSYQPTSFQSMAVHTPPAYTLRQIPPAHSIGYPYTSTAPTSESIILTAPTTTPSSTVYHTTQGSAIVKPLSDNQSQRDKLPYLMHKSQWHSNVTGHVPLSPGLPRRFVDGVLPPETSAHIQYSSGQSSPSPAGSATPVPTPRRESLAGSVPVRAGPAPPALATHELSSDANCTLTPPPVATRPEKTKSIYTKPVEAQCDGHLTIGDQQDASRRSLETPVPPQTAATIHGSENETRTNVTVLPTVHSDGNNSSVHAYQQATESRPLKPNTLERQGQKKVRPKISDEAIQEKLRMIVSIGDPNRKYQRQEKIGQGASGTVYGGIEVATGRRVAIKQMNLKQQPKKELIVNEIYVMKAKKHPNVVNYLDSYLVADELWVVMEYLDGGSLTEVVTETYMEEGQIAAVCRECLQALDFLHKNQVIHRDIKSDNILLGLDGSVKLTDFGFCAQLSSEQNKRSTMVGTPYWMAPEVVTRKQYGPKVDIWSLGIMAIEMLDGEPPYLNENPVRALYLIGTNGKPEIKERDKLSSEFQDFLDLCLEVKVERRATAQELLQHIFSRDGHRAMELLQTDNFHSSGVRKKRTPRLAIEKLVDPEVKRNYQNQLVECLPDGTVSDINGHWEKISKALLKPRRTVVMAAGEDELVVTVRGTSFNCPPTSLVEPNTGIIAPLIEPHHRGIGSYALEVVADIIGTLDYCGIAFLTMGSFVPYLYYSFYCVLWLKLFYLALIFALGSGAIAVSMSNTFASPAYRPLRALVFIALGLSGVIPCVHVTITNGFWPSLQHGSLGWLFLMAVLYITGASIYAVRVPERIFPGRFDIWFQSHQIFHVFVVAAALVHYHGIIGLTNYRLAIGDCRPPPGYPFPKHDYDNIELLRPFMTY,negative +ACGCGCTAGGATCAAAGCTGCACTGAAGTG,MANLGYWLLALFVTMWTDVGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGTWGQPHGGGWGQPHGGSWGQPHGGSWGQPHGGGWGQGGGTHNQWNKPSKPKTNLKHVAGAAAAGAVVGGLGGYMLGSAMSRPMIHFGNDWEDRYYRENMYRYPNQVYYRPVDQYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCVTQYQKESQAYYDGRRSSSTVLFSSPPVILLISFLIFLIVG,negative +GGGAGGACGAUGCGGACCGAAAAAGACCUGACUUCUAUACUAAGUCUACGUUCCCAGACGACUCGCCCGA,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +ACCAAAATCAACGCAAAGAGCGCGCCTGCACGTCACCTCA,MEGMLKGEGPGPLPPLLQQYVELRDQYPDYLLLFQVGDFYECFGEDAERLARALGLVLTHKTSKDFTTPMAGIPLRAFEAYAERLLKMGFRLAVADQVEPAEEAEGLVRREVTQLLTPGTLLQESLLPREANYLAAIATGDGWGLAFLDVSTGEFKGTVLKSKSALYDELFRHRPAEVLLAPELLENGAFLDEFRKRFPVMLSEAPFEPEGEGPLALRRARGALLAYAQRTQGGALSLQPFRFYDPGAFMRLPEATLRALEVFEPLRGQDTLFSVLDETRTAPGRRLLQSWLRHPLLDRGPLEARLDRVEGFVREGALREGVRRLLYRLADLERLATRLELGRASPKDLGALRRSLQILPELRALLGEEVGLPDLSPLKEELEAALVEDPPLKVSEGGLIREGYDPDLDALRAAHREGVAYFLELEERERERTGIPTLKVGYNAVFGYYLEVTRPYYERVPKEYRPVQTLKDRQRYTLPEMKEKEREVYRLEALIRRREEEVFLEVRERAKRQAEALREAARILAELDVYAALAEVAVRYGYVRPRFGDRLQIRAGRHPVVERRTEFVPNDLEMAHELVLITGPNMAGKSTFLRQTALIALLAQVGSFVPAEEAHLPLFDGIYTRIGASDDLAGGKSTFMVEMEEVALILKEATENSLVLLDEVGRGTSSLDGVAIATAVAEALHERRAYTLFATHYFELTALGLPRLKNLHVAAREEAGGLVFYHQVLPGPASKSYGVEVAAMAGLPKEVVARARALLQAMAARREGALDAVLERLLALDPDRLTPLEALRLLQELKALALGAPLDTMKG,negative +ACCCCTCTTACCCGAAGCGTTAAGCGGTGGAGGCTGTCA,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +GGAGUCUUAGGCAGCGCGUUUUCGAGCUACUCCA,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +UAAUACGACUCACUAUAGGGAGGACGAUGCGGAAUUGAGGGACCACGCGCUGCUUGUUGUGAUAAGCAGUUUGUCGUGAUGGUCGGGCGAGUCGUCUG,MEDDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKEEIAEVANEIESLGSTEERKNMQRNKQVAMGRKKFNMDPKKGIQFLIENGLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERDEFSIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNTGVFQSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIKNEPFKIPVWFFLQNLYESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEDWIKCIKAAISRDPFYEMLAARKKKVSSTKRH,negative +GGUAGAUACGAUGGAUCAGGGUACCCCCUGUGGCCCGUCAACACAGGGGAAGUGGCAUGACGCGCAGCCA,MARVRGPRLPGCLALAALFSLVHSQHVFLAHQQASSLLQRARRANKGFLEEVRKGNLERECLEEPCSREEAFEALESLSATDAFWAKYTACESARNPREKLNECLEGNCAEGVGMNYRGNVSVTRSGIECQLWRSRYPHKPEINSTTHPGADLRENFCRNPDGSITGPWCYTTSPTLRREECSVPVCGQDRVTVEVIPRSGGSTTSQSPLLETCVPDRGREYRGRLAVTTSGSRCLAWSSEQAKALSKDQDFNPAVPLAENFCRNPDGDEEGAWCYVADQPGDFEYCDLNYCEEPVDGDLGDRLGEDPDPDAAIEGRTSEDHFQPFFNEKTFGAGEADCGLRPLFEKKQVQDQTEKELFESYIEGRIVEGQDAEVGLSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTVDDLLVRIGKHSRTRYERKVEKISMLDKIYIHPRYNWKENLDRDIALLKLKRPIELSDYIHPVCLPDKQTAAKLLHAGFKGRVTGWGNRRETWTTSVAEVQPSVLQVVNLPLVERPVCKASTRIRITDNMFCAGYKPGEGKRGDACEGDSGGPFVMKSPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDRLGS,negative +GGGACGCGTGGTACCAAAGAGGCTGCGCGGAAGTGAGGGTGTTGGTTACGAAGGTTGGTGTGTGAAGCTT,MPVKMVAVLGASTVLWILFAVSQAFKIEISPEYKTIAQIGDSMALTCSTTGCESPLFSWRTQIDSPLNAKVRTEGSKSVLTMEPVSFENEHSYLCTATCGSGKLERSIHVDIYSFPKDPEIQFSGPLEVGKPVTVKCLAPDIYPVYRLEIDLFKGDQLMNRQEFSSEEMTKSLETKSLEVTFTPVIEDIGKALVCRAKLHIDQIDSTLKERETVKELQVYISPRNTTISVHPSTRLQEGGAVTMTCSSEGLPAPEIFWGRKLDNEVLQLLSGNATLTLIAMRMEDSGVYVCEGVNLIGRDKAEVELVVQEKPFIVDISPGSQVAAQVGDSVVLTCAAIGCDSPSFSWRTQTDSPLNGVVRNEGAKSTLVLSSVGFEDEHSYLCAVTCLQRTLEKRTQVEVYSFPEDPVIKMSGPLVHGRPVTVNCTVPNVYPFDHLEIELLKGETTLMKKYFLEEMGIKSLETKILETTFIPTIEDTGKSLVCLARLHSGEMESEPKQRQSVQPLYVNVAPKETTIWVSPSPILEEGSPVNLTCSSDGIPAPKILWSRQLNNGELQPLSENTTLTFMSTKRDDSGIYVCEGINEAGISRKSVELIIQVSPKDIQLTVFPSKSVKEGDTVIISCTCGNVPETWIILKKKAKTGDMVLKSVDGSYTIRQAQLQDAGIYECESKTEVGSQLRSLTLDVKGKEHNKDYFSPELLALYCASSLVIPAIGMIVYFARKANMKGSYSLVEAQKSKV,negative +AATACCCTCCCTTCGGTGCAAAGCACCGAAGGGAGGG,MKPGGNTIVIWMYAVATWLCFGSTSGWSFTLEDNNIFPKQYPIINFTTAGATVQSYTNFIRAVRGRLTTGADVRHEIPVLPNRVGLPINQRFILVELSNHAELSVTLALDVTNAYVVGYRAGNSAYFFHPDNQEDAEAITHLFTDVQNRYTFAFGGNYDRLEQLAGNLRENIELGNGPLEEAISALYYYSTGGTQLPTLARSFIICIQMISEAARFQYIEGEMRTRIRYNRRSAPDPSVITLENSWGRLSTAIQESNQGAFASPIQLQRRNGSKFSVYDVSILIPIIALMVYRCAPPPSSQFSLLIRPVVPNFNADVCMDPEPIVRIVGRNGLCVDVRDGRFHNGNAIQLWPCKSNTDANQLWTLKRDNTIRSNGKCLTTYGYSPGVYVMIYDCNTAATDATRWQIWDNGTIINPRSSLVLAATSGNSGTTLTVQTNIYAVSQGWLPTNNTQPFVTTIVGLYGLCLQANSGQVWIEDCSSEKAEQQWALYADGSIRPQQNRDNCLTSDSNIRETVVKILSCGPASSGQRWMFKNDGTILNLYSGLVLDVRASDPSLKQIILYPLHGDPNQIWLPLF,negative +ATCGATGACCCGTAGTGCAGTGAATTACGT,QDRPIKFSTEGATSQSYKQFIEALRERLRGGLIHDIPVLPDPTTLQERNRYITVELSNSDTESIEVGIDVTNAYVVAYRAGTQSYFLRDAPSSASDYLFTGTDQHSLPFYGTYGDLERWAHQSRQQIPLGLQALTHGISFFRSGGNDNEEKARTLIVIIQMVAEAARFRYISNRVRVSIQTGTAFQPDAAMISLENNWDNLSRGVQESVQDTFPNQVTLTNIRNEPVIVDSLSHPTVAVLALMLFVCNPPNANQSPLLIRSIVEKSKICSSRYEPTVRIGGRDGMCVDVYDNGYHNGNRIIMWKCKDRLEENQLWTLKSDKTIRSNGKCLTTYGYAPGSYVMIYDCTSAVAEATYWEIWDNGTIINPKSALVLSAESSSMGGTLTVQTNEYLMRQGWRTGNNTSPFVTSISGYSDLCMQAQGSNVWMADCDSNKKEQQWALYTDGSIRSVQNTNNCLTSKDHKQGSTILLMGCSNGWASQRWVFKNDGSIYSLYDDMVMDVKGSDPSLKQIILWPYTGKPNQIWLTLF,negative +ATACCAGTCTATTCAATTGGGCCCGTCCGTATGGTGGGTGTGCTGGCCAGATAGTATGTGCAATCA,MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP,negative +AAUAGCAAAAAAAAACAUGAAGUGCAACGC,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,negative +AAAAAGGAGGAGGAGGA,MNQTAILICCLIFLTLSGIQGVPLSRTVRCTCISISNQPVNPRSLEKLEIIPASQFCPRVEIIATMKKKGEKRCLNPESKAIKNLLKAVSKERSKRSP,negative +GACCGGUGUGUCCUGAUCCAACUGCCACAAGUACCAUAUGCAGGUGACGU,MEYASDASLDPEAPWPPAPRARACRVLPWALVAGLLLLLLLAAACAVFLACPWAVSGARASPGSAASPRLREGPELSPDDPAGLLDLRQGMFAQLVAQNVLLIDGPLSWYSDPGLAGVSLTGGLSYKEDTKELVVAKAGVYYVFFQLELRRVVAGEGSGSVSLALHLQPLRSAAGAAALALTVDLPPASSEARNSAFGFQGRLLHLSAGQRLGVHLHTEARARHAWQLTQGATVLGLFRVTPEIPAGLPSPRSE,negative +AUGACGUACCCGCACAAGCCACCACAAGUCUUAAUCGCGCCACCCUUGC,MTPDIQAPFLSLLLLFPVLTVANVPTLTTSDSINPRRTTPVSTTQSSPTSSPTKETSWSTTTTLLTASSPAPSPAASPGHDGASTPTSSPAPSPAASPGHDGASTPTSSPAPSPAASPGHDGASTPTSSPAPSPAASPGHDGASTPTSSPAPSPAASPGHNGTSSPTGSPAPSPAASPGHDGASTPTSSPAPSPAASPGHNGTSSPTGSPAPSPAASPGHDGASTPTSSPAPSPAASPGHNGTSSPTGSPAPSPTASPGHDSAPSLTSSPAPSPTASPGQHGASSPTSSDTSSMTTRSMSSSMVTSAHKGTSSRATMTPVSKGTPSSVPSSETAPTAASHITRTAASSPSIALSTSSNPKTSQQLSVRVSLYFLSFRITNLQFNSSLENPQTSYYQELQRSIWGLILQIYKQRDFLGLSEIKFRPGSVVVELTLAFREGTTAEWVKAQFSQLEAHAASYNLTISGVSVYSAPFPSSAQAGSGVPGWGIALLVLVCVLVALAIIYLIALVVCQCGRKKCEQLDVFPTLDAYHPMSEYSTYHTHGRYVPPGSTKRSPYEEVSAGNGGSNLSYTNLAATSANL,negative +GCAGAACCACCCCCUUCCAUCACUCCAGCC,MNIKAILSLCLFLILQCVRARVFVSRLEAASLLARSRRANSPFSMEETKQGSLERECREETCNFEEAREIFEDDQRTNAFWTLYIRPNPCLSNPCQNGGTCQHTHTVYMCVCPRGWEGRVCSQEVSTGQSCKVNNGRCDHYCEEEEAAAGGRRGAVCSCAPGYHLARNRRSCMAMEAFPCGRVASPKSDILMGNSSEAATDVPTPTSQAANVNSSSIIGDDSEPQASFGHSNHRGRVVGGKECPRGQCPWQVLISRKGAPVCGGTILSPQWILTAAHCTIYETKNLRILAGEHNVDEVEGSEQELGILRIVDHPSFNIKLSYDNDISLIQLSRPIQFTRYALPICLPNQRFVRGVLRSVVAGTVSGWGKLNEFGPAAGILQRLEVPYVDDEQCRAAMGSKVITANMFCAGYETGGQDSCSGDSGGPHATRYGSTWFLTGVVSWGKGCAREGKFGVYTKVLNYLDWIAQTMAETESHALPEPAQH,negative +CUCUUUUUGUCCCCGCACGUUGAACUCCUGUCCCUCUACU,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +CTTCTGCCCGCCTCCTTCCCTAGTGCAGGGGTTCACTCAGGACCTTACGAGCTTTTTCGGAGACGAGATAGGCGGACACT,MKEFEVKVASTAFVLVLFSLTINQILASETSTKFRSPVPAPTVPDWNHLPNEGNEENVVSAPKQDGASGGQKPYWTKREKMMKRLHAEPAGNTVRFRCAVDGNPKPQVLWYKNDLIVQKNDRVGGYKYRNQVLILESVVLSDKGNYMCVARNEYGSINHTYQLDVQERSASKPILAEGLPQNKSAYIGDDVTFKCKVYSDAHPHIQWLKSINNHNNAAPNYTVLKAAGVNTTDLDMEVLILKNVSFEEAGEYTCLAGNSIGISHQSAWLSVLPVPPPTTDTITKGIPNETNIIIYVMCGVLVILFGLAVVLVLYYHCYNGKDPPMLVRIENPDNIPPMTKIEHPTMLFGNTQAWQRMCMPMQEPFEFNIQLDLQWELQREDITLVERLDEGFFGQVFKADLVTCNNTRKEKMVCAVKMLKGNRNEKDVLDLLTEMDQMKRVGKHKNIINLLGVCTQNGPLWLVIEYAAQGNLRDYLRRNRPQNTLCNLVLPSEGRNPDDELPVPHGDTLTQKDIVSFAFQVARGLEFLAQKKCIHRDLAARNVLVTEELVMKIADFGLARDIRSCDYYRKHTRGHLPYKWMALEAMSDNIFTHATDVWSFGVLLWEIFSLAGSPYPGIKTHELVKFLRSGERLDKPQYASQEMYRLMRDCWEEDPSKRPNFRTLVEDLDRMLAESSTEVYIDFAAGCEAEYSESSEDESESQNSDEEDDDSVFERMRQIDSLSNGNIPFNEEDSSNSDPYVAPLLQNEENVLQNEHARLRSEA,negative +GUACAACACAUCAUUACGGCUGCUAUUGGCUCCAAGCGUCUUUCUCCCUGGUCAAUAGUCCGCCACCACG,ASFTCLAIWALASAGVVPLVLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAAFFFVPVIISTVCYVSIIRCLSSSAVANRSKK,negative +GCGCAAACCCGAAGAAUGCCCAAAUUGAUCCAGAGCAAGUGGGAAUGAUAUAAAGUACCUGGUCCUGG,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,negative +CCCAGGAUCACCGGG,MEDDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKEEIAEVANEIESLGSTEERKNMQRNKQVAMGRKKFNMDPKKGIQFLIENGLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERDEFSIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNTGVFQSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIKNEPFKIPVWFFLQNLYESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEDWIKCIKAAISRDPFYEMLAARKKKVSSTKRH,negative +GGGACACAAUGGACGCACCUCCGACGCACAGUCGCAGGCUCGAAAGAGACUAAAUGCUAACGGCCGACAUGAGAG,MLSWGYFLFLLPTLPGAQSQVQLVESGGDVRKPGDSLRLSCKGSGFTFSNYWLGWVRQAPGKALNGSLPLTPLAAAPTYIPGVSGRFTISRDNARALLHLDMSDLRPEDTGRYHCER,negative +TCGGATGCGCCGAGTCTCCGTTTACCTTCGT,MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPGPHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR,negative +GACCGGUGUGUCCUGAUCCAACUGCCACAAGUACCAUAUGCAGGUGACGU,MSAPASTTQATGSTTSTTTKTAGATPATASGLFTIPDGDFFSTARAVVASDAVATNEDLSEIEAVWKDMKVPTDTMAQAAWDLVRHCADVGSSAQTEMIDTGPYSNGISRARLAAAIKEVCTLRQFCMKYAPVVWNWMLTNNSPPANWQAQGFKPEHKFAAFDFFNGVTNPAAIMPKEGLIRPPSEAEMNAAQTAAFVKITKARAQSNDFASLDAAVTRGRITGTTTAEAVVTLPPP,negative +GGGAGCTCAGAATAAACGCTCAACATGGATGGGAGGGTGGGGCTGGGTTGTAGAATATTCGACATGAGGCCCGGATC,MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK,negative +TAGGGAATTCGTCGACGGATCCCGATACGCACTACAAACGGCGCATGCGTCGACCTGGAG,MAGRSGDSDEELLKAVRLIKFLYQSNPPPNPEGTRQARRNRRRRWRERQRQIHSISERILSTYLGRSAEPVPLQLPPLERLTLDCNEDCGTSGTQGVGSPQILVESPTILESGAKE,negative +GGAGUCUUAGGCAGCGCGUUUUCGAGCUACUCCA,MGLLGILCFLIFLGKTWGQEQTYVISAPKIFRVGASENIVIQVYGYTEAFDATISIKSYPDKKFSYSSGHVHLSSENKFQNSAILTIQPKQLPGGQNPVSYVYLEVVSKHFSKSKRMPITYDNGFLFIHTDKPVYTPDQSVKVRVYSLNDDLKPAKRETVLTFIDPEGSEVDMVEEIDHIGIISFPDFKIPSNPRYGMWTIKAKYKEDFSTTGTAYFEVKEYVLPHFSVSIEPEYNFIGYKNFKNFEITIKARYFYNKVVTEADVYITFGIREDLKDDQKEMMQTAMQNTMLINGIAQVTFDSETAVKELSYYSLEDLNNKYLYIAVTVIESTGGFSEEAEIPGIKYVLSPYKLNLVATPLFLKPGIPYPIKVQVKDSLDQLVGGVPVTLNAQTIDVNQETSDLDPSKSVTRVDDGVASFVLNLPSGVTVLEFNVKTDAPDLPEENQAREGYRAIAYSSLSQSYLYIDWTDNHKALLVGEHLNIIVTPKSPYIDKITHYNYLILSKGKIIHFGTREKFSDASYQSINIPVTQNMVPSSRLLVYYIVTGEQTAELVSDSVWLNIEEKCGNQLQVHLSPDADAYSPGQTVSLNMATGMDSWVALAAVDSAVYGVQRGAKKPLERVFQFLEKSDLGCGAGGGLNNANVFHLAGLTFLTNANADDSQENDEPCKEILRPRRTLQKKIEEIAAKYKHSVVKKCCYDGACVNNDETCEQRAARISLGPRCIKAFTECCVVASQLRANISHKDMQLGRLHMKTLLPVSKPEIRSYFPESWLWEVHLVPRRKQLQFALPDSLTTWEIQGVGISNTGICVADTVKAKVFKDVFLEMNIPYSVVRGEQIQLKGTVYNYRTSGMQFCVKMSAVEGICTSESPVIDHQGTKSSKCVRQKVEGSSSHLVTFTVLPLEIGLHNINFSLETWFGKEILVKTLRVVPEGVKRESYSGVTLDPRGIYGTISRRKEFPYRIPLDLVPKTEIKRILSVKGLLVGEILSAVLSQEGINILTHLPKGSAEAELMSVVPVFYVFHYLETGNHWNIFHSDPLIEKQKLKKKLKEGMLSIMSYRNADYSYSVWKGGSASTWLTAFALRVLGQVNKYVEQNQNSICNSLLWLVENYQLDNGSFKENSQYQPIKLQGTLPVEARENSLYLTAFTVIGIRKAFDICPLVKIDTALIKADNFLLENTLPAQSTFTLAISAYALSLGDKTHPQFRSIVSALKREALVKGNPPIYRFWKDNLQHKDSSVPNTGTARMVETTAYALLTSLNLKDINYVNPVIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVKQLRLSMDIDVSYKHKGALHNYKMTDKNFLGRPVEVLLNDDLIVSTGFGSGLATVHVTTVVHKTSTSEEVCSFYLKIDTQDIEASHYRGYGNSDYKRIVACASYKPSREESSSGSSHAVMDISLPTGISANEEDLKALVEGVDQLFTDYQIKDGHVILQLNSIPSSDFLCVRFRIFELFEVGFLSPATFTVYEYHRPDKQCTMFYSTSNIKIQKVCEGAACKCVEADCGQMQEELDLTISAETRKQTACKPEIAYAYKVSITSITVENVFVKYKATLLDIYKTGEAVAEKDSEITFIKKVTCTNAELVKGRQYLIMGKEALQIKYNFSFRYIYPLDSLTWIEYWPRDTTCSSCQAFLANLDEFAEDIFLNGC,negative +GGUUGGGUUGUCGUAGAUAUAGCUUAGCCA,MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYTFLLPEMDNCRSSSSPYVSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQDNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVLVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF,negative +CAGGAUGAACAAGCAGGACGUGAAAUGAAC,MDHLNEATQGKEHSEMSNNVSDPKGPPAKIARLEQNGSPLGRGRLGSTGAKMQGVPLKHSGHLMKTNLRKGTMLPVFCVVEHYENAIEYDCKEEHAEFVLVRKDMLFNQLIEMALLSLGYSHSSAAQAKGLIQVGKWNPVPLSYVTDAPDATVADMLQDVYHVVTLKIQLHSCPKLEDLPPEQWSHTTVRNALKDLLKDMNQSSLAKECPLSQSMISSIVNSTYYANVSAAKCQEFGRWYKHFKKTKDMMVEMDSLSELSQQGANHVNFGQQPVPGNTAEQPPSPAQLSHGSQPSVRTPLPNLHPGLVSTPISPQLVNQQLVMAQLLNQQYAVNRLLAQQSLNQQYLNHPPPVSRSMNKPLEQQVSTNTEVSSEIYQWVRDELKRAGISQAVFARVAFNRTQGLLSEILRKEEDPKTASQSLLVNLRAMQNFLQLPEAERDRIYQDERERSLNAASAMGPAPLISTPPSRPPQVKTATIATERNGKPENNTMNINASIYDEIQQEMKRAKVSQALFAKVAATKSQGWLCELLRWKEDPSPENRTLWENLSMIRRFLSLPQPERDAIYEQESNAVHHHGDRPPHIIHVPAEQIQQQQQQQQQQQQQQQAPPPPQPQQQPQTGPRLPPRQPTVASPAESDEENRQKTRPRTKISVEALGILQSFIQDVGLYPDEEAIQTLSAQLDLPKYTIIKFFQNQRYYLKHHGKLKDNSGLEVDVAEYKEEELLKDLEESVQDKNTNTLFSVKLEEELSVEGNTDINTDLKD,negative +GAGACGGCCAGCCAAGGCGCUGAGAUCCGAGGUUUCAG,WPLTEEKIKALVEICXEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEEFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDXIIYQYMDDLYVGSDLEIGQHRTKVEELRQHLLXWGFTTPDKKHQKEPPFLWMGYELHP,negative +ATCTCGGGTTTGGACTCCTGTTTATTTATAAGGAGACGAGAT,MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC,negative +CGAATACCTGGAGGAACACGGGAAAAGATCACTGAAGCCA,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +CCCCCAUGGCACGCCGAUCACGUUUUGCUGUCCGCCGGUCCAUAAAUACU,MNQVTIQWDAVIALYILFSWCHGGITNINCSGHIWVEPATIFKMGMNISIYCQAAIKNCQPRKLHFYKNGIKERFQITRINKTTARLWYKNFLEPHASMYCTAECPKHFQETLICGKDISSGYPPDIPDEVTCVIYEYSGNMTCTWNAGKLTYIDTKYVVHVKSLETEEEQQYLTSSYINISTDSLQGGKKYLVWVQAANALGMEESKQLQIHLDDIVIPSAAVISRAETINATVPKTIIYWDSQTTIEKVSCEMRYKATTNQTWNVKEFDTNFTYVQQSEFYLEPNIKYVFQVRCQETGKRYWQPWSSLFFHKTPETVPQVTSKAFQHDTWNSGLTVASISTGHLTSDNRGDIGLLLGMIVFAVMLSILSLIGIFNRSFRTGIKRRILLLIPKWLYEDIPNMKNSNVVKMLQENSELMNNNSSEQVLYVDPMITEIKEIFIPEHKPTDYKKENTGPLETRDYPQNSLFDNTTVVYIPDLNTGYKPQISNFLPEGSHLSNNNEITSLTLKPPVDSLDSGNNPRLQKHPNFAFSVSSVNSLSNTIFLGELSLILNQGECSSPDIQNSVEEETTMLLENDSPSETIPEQTLLPDEFVSCLGIVNEELPSINTYFPQNILESHFNRISLLEK,negative +UAUUAUGCCUUUAGCUAGCGCAUUCUGUGGGGUGGGUGGA,MRKIVVAAIAVSLTTVSITASASADPSKDSKAQVSAAEAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKVKPSAASIDAAKKAGVNNGNPLDAVQQ,negative +GTAGATTGAATTAATTGGAAGAGTCGATCAGTGTTTAATG,PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGKISKIGPENPYNTPVFAIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDESFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPXRXKNPEMVIYQYMDDLYVGSDLEIGQHRAKIEELRSHLLSWGFTTPDKKHQKEPPFLWMGYELHPDSWTVQPIELPEKDSWTVNE,negative +GGACCUUUGUACCCCAGAUGAUAGUAAAGCGCGGCUUGAUGGGUACAAAUGGCAG,MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTSQVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHPTNVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEALGYRQDDPSYRSFHSAGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL,negative +GUCUAGCUCUAGCCCCUGAUUACUUAAAGUGAUCACACAG,MIPPPRRSASSTPKDYRSSRDLQPWRGVSSGDAAETSQQSRHRRDAIADGGGRLKGAAQSSPSSGTRRSGPYAQGRAMPKNENIPKPGKQRLGPRKKKLSTLKKKILLDRLERWRDKQHEGALSTPSATASSEEAKCNNPFPLCPPGELSPPPSPPATICPAVVDKSTSYGQVGGANGERSVWAITIYNLVDQEDVEDDDDHAEIERDLWDMSSAFGVVRSVQVPRGTAVQVSDAEVSAAAAAGEPAAVAAKVAFATNAEAECARDGLNGRIVGGKPLLVRIHRCDGHFCGGVCPGDPDGSGLWRVAIENLIDEEDDLDDEDEYAEISANVSAMMGCYGKLVDVQVRRSSPSKGEVQEDVATRAATTAGATQAVVVTFGSLAEAEACVQGIKGCRVGGKELDAHVVLDSERVLPSNPAFKCDQEHAHSSDVAAAVAGQGDSMMKQEAGTEPSPCVDQDTAAAVASSTEWRVVIRGLIDEDDLQDDDDDYAEVCSDVTALVSSYGAVVGLDIPRGRETGSCCYGAEPGEAVVVFRSLQEAEACARGLSGRKVAGNILDAQVLTQPAPSQQGPLQGGASGTGPPVANRERKPAKECPLPQHQASSHQSCGKVPELDGSGPGMLRGFGNRVEDCCGRPKIACTDSDEPQAIAAAAPPGQSIEGPKTTALAKAGKRIQTKYQEAAALPKPPGVRGGLPNAYVNQPPDKEVNDLVFEMLQLLFKFQERARLSDPSKAKTRRRLVIGLREVLRGVKAKKVRLLIVAPNVDAVGGEGGLDDKVVEIIDKAREAEYPVVFALSKRKIGKALGKTIKVSAVGVYSFDGANEQQKQLKRRMETISSLPSPSPRQSDPPTDDALASPPSSSACGDSQDPAGKGSRV,negative +GGCGGCCGTGAAATTTGCCAAATGCCGTCTTGGCTTTCGCCCAATGTATCCTGGGTGTTC,QELLCAASLISDRWVLTAAHCLLYPPWDKNFTVNDILVRIGKYARSRYERNMEKISTLEKIIIHPGYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDKQIVTSLLQAGHKGRVTGWGNLKEMWTVNMNEVQPSVLQMVNLPLVERPICKASTGIRVTDNMFCAGYKPEEGKRGDACEGDSGGPFVMKNPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIRKMVDRFG,negative +UCGUGCCUUUUCUCGAUGGAGUGAGAAGAGGUGACGG,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,negative +GGTTGTGAAGATTGGGAGCGTCGTGGCTAC,VFTDNSSPPAVPQSFQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGFGAYMSKAHGVDPNIRTGVRTITTGSPITYSTYGKFLADGGCSGGAYDIIICDECHSTDATSILGIGTVLDQAETAGARLVVLATATPPGSVTVSHPNIEEVALSTTGEIPFYGKAIPLEVIKGGRHLIFCHSKKKCDELAAKLVALGINAVAYYRGLDVSVIPTSGDVVVVSTDALMTGFTGDFDSVIDCNTCVTQTVDFSLDPTFTIETTTLPQDAVSRTQRRGRTGRGKPGIYRFVAPGERPSGMFDSSVLCECYDAGCAWYELTPAETTVRLRAYMNTPGLPVCQDHLEFWEGVFTGLTHIDAHFLSQTKQSGENFPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPTLHGPTPLLYRLGAVQNEVT,negative +AGAGUCGCUGAUGGUAGACGCCGGCGGAUC,MTPDIQAPFLSLLLLFPVLTVANVPTLTTSDSINPRRTTPVSTTQSSPTSSPTKETSWSTTTTLLTASSPAPSPAASPGHDGASTPTSSPAPSPAASPGHDGASTPTSSPAPSPAASPGHDGASTPTSSPAPSPAASPGHDGASTPTSSPAPSPAASPGHNGTSSPTGSPAPSPAASPGHDGASTPTSSPAPSPAASPGHNGTSSPTGSPAPSPAASPGHDGASTPTSSPAPSPAASPGHNGTSSPTGSPAPSPTASPGHDSAPSLTSSPAPSPTASPGQHGASSPTSSDTSSMTTRSMSSSMVTSAHKGTSSRATMTPVSKGTPSSVPSSETAPTAASHITRTAASSPSIALSTSSNPKTSQQLSVRVSLYFLSFRITNLQFNSSLENPQTSYYQELQRSIWGLILQIYKQRDFLGLSEIKFRPGSVVVELTLAFREGTTAEWVKAQFSQLEAHAASYNLTISGVSVYSAPFPSSAQAGSGVPGWGIALLVLVCVLVALAIIYLIALVVCQCGRKKCEQLDVFPTLDAYHPMSEYSTYHTHGRYVPPGSTKRSPYEEVSAGNGGSNLSYTNLAATSANL,negative +UGGUCUCCCAAUUCUAAACUUUCUCCAUCGUAUCUGGG,MSSTESPVPAAAAPAEAVPASTPAPAAEQPAVGNGEQRNNADAANNTSLYVGELDPSVTEAMLFEIFSMIGTVASIRVCRDAVTRRSLGYAYVNFLNAADGERAMEQLNYSLIRNRPCRIMWSQRDPALRRTGQGNIFIKNLDAGIDNKALHDTFAAFGNILSCKVATNETGSLGYGFVHYETAEAAEAAIKHVNGMLLNDKKVYVGHHIPRKERQAKIEETRANFTNVYAKNVDPEVTDDEFEKLFTKFGKITSCVLQRDEDGKSKGFGFVNFEDHNEAQKAVDELHDSDFKGQKLFVARAQKKSEREEELRRSYEAAKNEKLAKFQGVNLYLKNIPESYDDERLREEFAPFGAITSCKIMRAPSGVSRGFGFVCYSAPEEANKAVSEMNGKMLDNRPLYVALAQRKDVRRQQLEAQIMQRNQLRLQQQAAAQGMGYPGPGMYYPQPGAFPGQPGGMVPRPRYAPAGMMPQGMPMAPYGQPGQFPAGMMPQGYRPARPPRGAPNAAGGPAPPAGARPPTGVNGAPRPAGQPVPGQPMPRGPAARPAGRPEADQPGALTAAALAKASPEEQKQMLGEAIYPKVAASQPELAGKLTGMILELPVTELLHLLEESEALDAKVNEALEVLKEYQQNDSAGAEAEANAEAPKTEA,negative +GGGAGAAGGGAAGTAACAGGCUAGAAGUUUAGACCAAGGGGCGGGAUGAGTGAGAAGAGGTGACGGTACCAG,ASFTCLAIWALASAGVVPLVLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAAFFFVPVIISTVCYVSIIRCLSSSAVANRSKK,negative +AUUACCGGCGAGUUUUGAACCGCGUAAU,MASTSRLDALPRVTCPNHPDAILVEDYRAGDMICPECDRVIDVGSEWRTFSNDKATKDPSRVGDSQNPLLSDGDLSTMIGKGTGAASFDEFGNSKYQNRRTMSSSDRAMMNAFKEITTMADRINLPRNIVDRTNNLFKQVYEQKSLKGRANDAIASACLYIACRQEGVPRTFKEICAVSRISKKEIGRCFKLILKALETSVDLITTGDFMSRFCSNLCLPKQVQMAATHIA,negative +AGATACGCTCGTGTTGCTCGATAGC,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +UACCGAAAACGCAUGCCUCUAGCCGUUCGAUACGAGCUGAGCAGCGGGCCAGUACUACAAGCUUCUGGACUCGGU,MSSSQKKAGGKAGKPTKRSQNYAALRKAQLPKPPALKVPVVKPTNTILPQTGCVWQSLGTPLSLSSFNGLGARFLYSFLKDFVGPRILEEDLIYRMVFSITPSHAGTFCLTDDVTTEDGRAVAHGNPMQEFPHGAFHANEKFGFELVFTAPTHAGMQNQNFKHSYAVALCLDFDAQPEGSKNPSFRFNEVWVERKAFPRAGPLRSLITVGLFDEADDLDRH,negative +GAATGAGGAATAATCTAGCTCCTTCGCTGA,MGCRRTREGPSKAMIFPWKCQSTQRDLWNIFKLWGWTMLCCDFLAHHGTDCWTYHYSEKPMNWQRARRFCRDNYTDLVAIQNKAEIEYLEKTLPFSRSYYWIGIRKIGGIWTWVGTNKSLTEEAENWGDGEPNNKKNKEDCVEIYIKRNKDAGKWNDDACHKLKAALCYTASCQPWSCSGHGECVEIINNYTCNCDVGYYGPQCQFVIQCEPLEAPELGTMDCTHPLGNFSFSSQCAFSCSEGTNLTGIEETTCGPFGNWSSPEPTCQVIQCEPLSAPDLGIMNCSHPLASFSFTSACTFICSEGTELIGKKKTICESSGIWSNPSPICQKLDKSFSMIKEGDYNPLFIPVAVMVTAFSGLAFIIWLARRLKKGM,negative +CAGAUACAGGCCAUGUGC,MGVLLTQRTLLSLVLALLFPSMASMAAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQGLDVPKLREHCRERPGAFPSEETLRGLGRRGFLQTLNATLGCVLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILGLRNNIYCMAQLLDNSDTAEPTKAGRGASQPPTPTPASDAFQRKLEGCRFLHGYHRFMHSVGRVFSKWGESPNRSRRHSPHQALRKGVRRTRPSRKGKRLMTRGQLPR,negative +AAGACGGCCCGGUAUGUAGCCGGAGAUCCGAGACUUGCU,MAGRSGDSDEELLKAVRLIKFLYQSNPPPNPEGTRQARRNRRRRWRERQRQIHSISERILSTYLGRSAEPVPLQLPPLERLTLDCNEDCGTSGTQGVGSPQILVESPTILESGAKE,negative +CCGACCTCCATGGAAACATTCTGCGACTACTTACTGGCC,QELLCAASLISDRWVLTAAHCLLYPPWDKNFTVNDILVRIGKYARSRYERNMEKISTLEKIIIHPGYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDKQIVTSLLQAGHKGRVTGWGNLKEMWTVNMNEVQPSVLQMVNLPLVERPICKASTGIRVTDNMFCAGYKPEEGKRGDACEGDSGGPFVMKNPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIRKMVDRFG,negative +CTCCTCTGACTGTAACCACGAGAAATTGGTACTGTATGAAACGGCAGCTGCACGTCGCGGCATAGGTAGTCCAGAAGCC,MNRNCASPEEGGTTEQLVKEASDIVERDGFENKKKPPTLKLEHVEVVGEKSPTPATVYDLFKKYKKPDIVTNSNGDDMNVGFDQLSSDEKNGFLRKLQMLTVSSRKSVKVVGESTPSSAGRLLKKFAPSRKPTEKISVDEPPSRFNFFGRSTKKLSDSDRPSSLPKKKSARRLLFGKEEQKPEPEVVKNRVLPAMTSQQSAKGAPIPINKPYRYQGPRGSLETPTDSPAKISSNSSSSSPIPPVPTRNHFTSMNEESPSKKRTFSRQGLSNRDNLSNGSWHGELPPRDYTSPTFSRKIFVGGVPWDITEAALKDSFGEFGSCAVEWPGQEARYRSGQSNIAPLTNLRNQSKYAGQAATGYVYMIFEDERAVASLLHECSQEIGGAGEWYFKIRAQRSKSTEIRQVQIIPWVTSDSMFCEDESLLETGIEPKRTVFVGALHGMMTAQVLHWIMEDCFGSVECVQLDTDKFKYPIGSGRVTFREHGAYFKAIEMGYLHVHTSKFRKRVQIDPFLESTSCMVCTTESAQCFCRNRNCFKYYCHTCWAIDHGKDNADDVHVPVIVPSSASKAYAGPHRRPHLTSNSLSKSHGCSTNNQLSHVLSPGFPMIVGGPSQTLSALYGYIQNNQQMMLTPAVYETPMTPPSNESNAKRRSFTEFQNPAIFFNPSSMMTPQKSATCSETPVPAFFTNSAAFLTPNSNYYGSPNHSSSNISQSPQQYYGANLYYGYMPPQVAYDGSTNGSKLSPIHVPHIPNYQ,negative +GGGUUAACAAGAUACCGAGAGAGCUGCAGCAUAAGCCUGCAGAGUGGACCAGUACUACAAGCUUCUGGACUCGGU,MPSNQEARLFLAVLVLAQVLPILVDSAAEKGFKQAFWQPLCQVSEELDDQPKGALFTLQAAASKIQKMRDAALRASIYAEINHGTNRAKAAVIVANHYAMKADSGLEALKQTLSSQEVTATATASYLKGRIDEYLNLLLQTKESGTSGCMMDTSGTNTVTKAGGTIGGVPCKLQLSPIQPKRPAATYLGKAGYVGLTRQADAANNFHDNDAECRLASGHNTNGLGKSGQLSAAVTMAAGYVTVANSQTAVTVQALDALQEASGAAHQPWIDAWKAKKALTGAETAEFRNETAGIAGKTGVTKLVEEALLKKKDSEASEIQTELKKYFSGHENEQWTAIEKLISEQPVAQNLVGDNQPTKLGELEGNAKLTTILAYYRMETAGKFEVLTQKHKPAESQQQAAETEGSCNKKDQNECKSPCKWHNDAENKKCTLDKEEAKKVADETAKDGKTGNTNTTGSSNSFVISKTPLWLAVLLF,negative +TATTAGTAATAATATTAGTAATAA,MRKIVVAAIAVSLTTVSITASASADPSKDSKAQVSAAEAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKVKPSAASIDAAKKAGVNNGNPLDAVQQ,negative +CTTCTGCCCGCCTCCTTCCCTGGAGTGACGGGCTTATTTGAATCGGGCGAACTGGACTGGAGACGAGATAGGCGGACACT,MAKGEFIRTKPHVNVGTIGHVDHGKTTLTAALTYVAAAENPNVEVKDYGDIDKAPEERARGITINTAHVEYETAKRHYSHVDCPGHADYIKNMITGAAQMDGAILVVSAADGPMPQTREHILLARQVGVPYIVVFMNKVDMVDDPELLDLVEMEVRDLLNQYEFPGDEVPVIRGSALLALEEMHKNPKTKRGENEWVDKIWELLDAIDEYIPTPVRDVDKPFLMPVEDVFTITGRGTVATGRIERGKVKVGDEVEIVGLAPETRKTVVTGVEMHRKTLQEGIAGDNVGLLLRGVSREEVERGQVLAKPGSITPHTKFEASVYILKKEEGGRHTGFFTGYRPQFYFRTTDVTGVVRLPQGVEMVMPGDNVTFTVELIKPVALEEGLRFAIREGGRTVGAGVVTKILE,negative +TTGACCGCT-GTGTGACGCAACACTCAATTTCTTCCAGCCGGTCCG,MLNQLDNLTERVRGSNKLVDRWLHVRKHLLVAYYNLVGIKPGKESYMRLNEKALDDFCQSLVDYLSAGHFSIYERILHKLEGNGQLARAAKIWPQLEANTQQIMDYYDSSLETAIDHDNYLEFQQVLSDIGEALEARFVLEDKLILLVLDAARVKHPA,negative +GACAUCUGUAAGUAAGAUUCUAUCUGCAAAGCGGUUAGGAGGGCUCGGACUCUGAUUGCCUCCCCGCACC,MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP,negative +TGCCTTGTTATTGTGGTGGGCGGGTGGGAC,WPLTEEKIKALVEICXEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEEFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDXIIYQYMDDLYVGSDLEIGQHRTKVEELRQHLLXWGFTTPDKKHQKEPPFLWMGYELHP,negative +GAAGCUUACAAGAAGGACAGCACGAAUAAAACCUGCGUAAAUCCGCCCCAUUUGUGUAAGGGUAGUGGGUCGAAUUCCGCUCA,MKKRKVLIPLMALSTILVSSTGNLEVIQAEVKQENRLLNESESSSQGLLGYYFSDLNFQAPMVVTSSTTGDLSIPSSELENIPSENQYFQSAIWSGFIKVKKSDEYTFATSADNHVTMWVDDQEVINKASNSNKIRLEKGRLYQIKIQYQRENPTEKGLDFKLYWTDSQNKKEVISSDNLQLPELKQKSSNSRKKRSTSAGPTVPDRDNDGIPDSLEVEGYTVDVKNKRTFLSPWISNIHEKKGLTKYKSSPEKWSTASDPYSDFEKVTGRIDKNVSPEARHPLVAAYPIVHVDMENIILSKNEDQSTQNTDSQTRTISKNTSTSRTHTSEVHGNAEVHASFFDIGGSVSAGFSNSNSSTVAIDHSLSLAGERTWAETMGLNTADTARLNANIRYVNTGTAPIYNVLPTTSLVLGKNQTLATIKAKENQLSQILAPNNYYPSKNLAPIALNAQDDFSSTPITMNYNQFLELEKTKQLRLDTDQVYGNIATYNFENGRVRVDTGSNWSEVLPQIQETTARIIFNGKDLNLVERRIAAVNPSDPLETTKPDMTLKEALKIAFGFNEPNGNLQYQGKDITEFDFNFDQQTSQNIKNQLAELNATNIYTVLDKIKLNAKMNILIRDKRFHYDRNNIAVGADESVVKEAHREVINSSTEGLLLNIDKDIRKILSGYIVEIEDTEGLKEVINDRYDMLNISSLRQDGKTFIDFKKYNDKLPLYISNPNYKVNVYAVTKENTIINPSENGDTSTNGIKKILIFSKKGYEIG,negative +GATTGAAAGGTCTGTTTTTGGGGTTGGTTTGGGTCAATA,MDSTNYISKLFEYAQRQGQISDIKFEEVGTDGPDHLKTFTLRVVIKGHAYPNGVGKTKKEAKRNAAKHALIGMMETTEQKDASVSCPPSPAPSPAPPVRAVISQPKYVSWLNEHSQKNKLSLKALEGARVGPNNTSQCCRYVVGEKEYPEGFGNTKKEAKEEAAMQVYLELCGGSQTTGTVDENCNGTTGKHKEELNGKVVVLSEKVEHMNMSPAQNVPEQYSFITTEETNFIGILNHYCQKTKRFLDFKLVEKSGPSHNPQFVYKVLIDKREYPDGLGKTAKEAKQQAAQLAWSALQEQSDWNSQVSCRSTVSEEGGLSSLTPSSTWESQDATPSSLSIAGSTSESIIFSDSVNVSSPKDESPVNVKPKIRLAANFQMSPVKTKQEGPNLKGNDLGTLSSGRTSNQPVISRFSSEFDSIENIGKGGFGHVYKARRKLEQKYFAVKIVRSKGKAKREVGALADLQHPNIVRYYTAWLEDTAYRCDTASESDTTSDSGSSSSSEFLYIQMELCDKRTLKVWIDERNAHRKPKRREESLSITQQIVNGVEYIHSKKLLHRDLKPANIMFGMSDGEGKGEVKIGDFGLVTAEDNDNDENLLERTKKTGTVSYMAPEQRNQTSYDRKVDIFALGLIYFEPLWDLSGMEKAKVWNDVRSQRFPQQFNSQFTLENKVIESLLCANPEERPDARQLKTKLNECSRVLTRVHNIHQDNRTI,negative +GGGCCGTTCGAACCGAGCATGGATCGAGGATGGGAACACCCAGTAGGAGGATGGGCATGGCCGGACCCAAAATTAGCAGTGGGACAGTACTCAGGTCATCCTAGG,SHGGLPCQNSQRGKRSFPAVEICKYKGPARIVVSLVTNEDTPRPHAHSLVGKHCKDGLCTVQVGPNDMTASFPNLGILHVTRKDVVPTLKTRILAQHRLYKDLINNSGGEGQWMEPSDQEIEKKAKEMAKDMDLSVVRLCFQTYLPDVKGHFTQPLEPVISVPVFDSKAPNATTLKICRMDKSAGCCTGGEEVYLLCDKVQKEVIQVKFFEVST,negative +GGGAAAAUAAUAAUAAA,MGVLLTQRTLLSLVLALLFPSMASMAAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQGLDVPKLREHCRERPGAFPSEETLRGLGRRGFLQTLNATLGCVLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILGLRNNIYCMAQLLDNSDTAEPTKAGRGASQPPTPTPASDAFQRKLEGCRFLHGYHRFMHSVGRVFSKWGESPNRSRRHSPHQALRKGVRRTRPSRKGKRLMTRGQLPR,negative +UAAAUCGUUGCUACAUUCCCAAUUGAACGGCCCGGGUUCUUAACACGUGC,MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINYDEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQAVAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQGIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADMDFSALLSQISS,negative +ACTCCAACGATCCCACCGCGACAAGGGTCATCGGCACCGT,MLNQLDNLTERVRGSNKLVDRWLHVRKHLLVAYYNLVGIKPGKESYMRLNEKALDDFCQSLVDYLSAGHFSIYERILHKLEGNGQLARAAKIWPQLEANTQQIMDYYDSSLETAIDHDNYLEFQQVLSDIGEALEARFVLEDKLILLVLDAARVKHPA,negative +GUAUUCUCGGUGGUUUAAUCAGAGUAGAGGAGGCUGACUCCUUUGGUUGGUCUACGUGGAGGUUCCUUUG,QELLCAASLISDRWVLTAAHCLLYPPWDKNFTVNDILVRIGKYARSRYERNMEKISTLEKIIIHPGYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDKQIVTSLLQAGHKGRVTGWGNLKEMWTVNMNEVQPSVLQMVNLPLVERPICKASTGIRVTDNMFCAGYKPEEGKRGDACEGDSGGPFVMKNPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIRKMVDRFG,negative +GGGACACAAUGGACGCACCUCCGACGCACAGUCGCAGGCUCGAAAGAGACUAAAUGCUAACGGCCGACAUGAGAG,MVKSHIGSWILVLFVAMWSDVGLCKKRPKPGGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGSHSQWNKPSKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGNDYEDRYYRENMYRYPNQVYYRPVDRYSNQNNFVHDCVNITVKQHTVTTTTKGENFTETDIKIMERVVEQMCITQYQRESQAYYQRGASVILFSSPPVILLISFLIFLIVG,negative +TCGGATGCGCCGAGTCTCCGTTTACCTTCGT,MAAGTAVGAWVLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISIIEPGEEGPTAGSVGGSGLGTLALALGILGGLGTAALLIGVILWQRRQRRGEERKAPENQEEEEERAELNQSEEPEAGESSTGGP,negative +GGGAGAGGAGAGAACGUUCUACCUUGCCUAACAGGAGGUGGAGUAUUGGACCCGCUGUCGAUCGAUCGAUCGAUG,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +GGGAGCTCAGAATAAACGCTCAAGGTGGTGGGCGGGGTGTAGAATTGGAAGGGATTCGACATGAGGCCCGGATC,MSGGDGRGHNTGAHSTSGNINGGPTGLGVGGGASDGSGWSSENNPWGGGSGSGIHWGGGSGHGNGGGNGNSGGGSGTGGNLSAVAAPVAFGFPALSTPGAGGLAVSISAGALSAAIADIMAALKGPFKFGLWGVALYGVLPSQIAKDDPNMMSKIVTSLPADDITESPVSSLPLDKATVNVNVRVVDDVKDERQNISVVSGVPMSVPVVDAKPTERPGVFTASIPGAPVLNISVNNSTPAVQTLSPGVTNNTDKDVRPAGFTQGGNTRDAVIRFPKDSGHNAVYVSVSDVLSPDQVKQRQDEENRRQQEWDATHPVEAAERNYERARAELNQANEDVARNQERQAKAVQVYNSRKSELDAANKTLADAIAEIKQFNRFAHDPMAGGHRMWQMAGLKAQRAQTDVNNKQAAFDAAAKEKSDADAALSSAMESRKKKEDKKRSAENNLNDEKNKPRKGFKDYGHDYHPAPKTENIKGLGDLKPGIPKTPKQNGGGKRKRWTGDKGRKIYEWDSQHGELEGYRASDGQHLGSFDPKTGNQLKGPDPKRNIKKYL,negative +UCGAAUCGAGUGGAAGUCACUUC,QDRPIKFSTEGATSQSYKQFIEALRERLRGGLIHDIPVLPDPTTLQERNRYITVELSNSDTESIEVGIDVTNAYVVAYRAGTQSYFLRDAPSSASDYLFTGTDQHSLPFYGTYGDLERWAHQSRQQIPLGLQALTHGISFFRSGGNDNEEKARTLIVIIQMVAEAARFRYISNRVRVSIQTGTAFQPDAAMISLENNWDNLSRGVQESVQDTFPNQVTLTNIRNEPVIVDSLSHPTVAVLALMLFVCNPPNANQSPLLIRSIVEKSKICSSRYEPTVRIGGRDGMCVDVYDNGYHNGNRIIMWKCKDRLEENQLWTLKSDKTIRSNGKCLTTYGYAPGSYVMIYDCTSAVAEATYWEIWDNGTIINPKSALVLSAESSSMGGTLTVQTNEYLMRQGWRTGNNTSPFVTSISGYSDLCMQAQGSNVWMADCDSNKKEQQWALYTDGSIRSVQNTNNCLTSKDHKQGSTILLMGCSNGWASQRWVFKNDGSIYSLYDDMVMDVKGSDPSLKQIILWPYTGKPNQIWLTLF,negative +UCGAAUCGAGUGGAAGUCACUUC,MKEFEVKVASTAFVLVLFSLTINQILASETSTKFRSPVPAPTVPDWNHLPNEGNEENVVSAPKQDGASGGQKPYWTKREKMMKRLHAEPAGNTVRFRCAVDGNPKPQVLWYKNDLIVQKNDRVGGYKYRNQVLILESVVLSDKGNYMCVARNEYGSINHTYQLDVQERSASKPILAEGLPQNKSAYIGDDVTFKCKVYSDAHPHIQWLKSINNHNNAAPNYTVLKAAGVNTTDLDMEVLILKNVSFEEAGEYTCLAGNSIGISHQSAWLSVLPVPPPTTDTITKGIPNETNIIIYVMCGVLVILFGLAVVLVLYYHCYNGKDPPMLVRIENPDNIPPMTKIEHPTMLFGNTQAWQRMCMPMQEPFEFNIQLDLQWELQREDITLVERLDEGFFGQVFKADLVTCNNTRKEKMVCAVKMLKGNRNEKDVLDLLTEMDQMKRVGKHKNIINLLGVCTQNGPLWLVIEYAAQGNLRDYLRRNRPQNTLCNLVLPSEGRNPDDELPVPHGDTLTQKDIVSFAFQVARGLEFLAQKKCIHRDLAARNVLVTEELVMKIADFGLARDIRSCDYYRKHTRGHLPYKWMALEAMSDNIFTHATDVWSFGVLLWEIFSLAGSPYPGIKTHELVKFLRSGERLDKPQYASQEMYRLMRDCWEEDPSKRPNFRTLVEDLDRMLAESSTEVYIDFAAGCEAEYSESSEDESESQNSDEEDDDSVFERMRQIDSLSNGNIPFNEEDSSNSDPYVAPLLQNEENVLQNEHARLRSEA,negative +GGGAGCTCAGAATAAACGCTCAAGAAGGTGGGAGGGTGGGGTGGTTGAAGAATGTTCGACATGAGGCCCGGATC,MAGRSGDSDEELLKAVRLIKFLYQSNPPPNPEGTRQARRNRRRRWRERQRQIHSISERILSTYLGRSAEPVPLQLPPLERLTLDCNEDCGTSGTQGVGSPQILVESPTILESGAKE,negative +CACUCGUACAUGUCCGUAGUUUUCCCACACUCCC,WPLTEEKIKALVEICXEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEEFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDXIIYQYMDDLYVGSDLEIGQHRTKVEELRQHLLXWGFTTPDKKHQKEPPFLWMGYELHP,negative +TATTAGTCATAATATTAGTCATAA,MVMGLGVLLLVFVLGLGLTPPTLAQDNSRYTHFLTQHYDAKPQGRDDRYCESIMRRRGLTSPCKDINTFIHGNKRSIKAICENKNGNPHRENLRISKSSFQVTTCKLHGGSPWPPCQYRATAGFRNVVVACENGLPVHLDQSIFRRP,negative +GGGAGAATTCCGACCAGAAGGCTTGCTGTTGTTTCCCTGTTGTTTTGTCTCTCAACTTTATTGTGGTAAAGATCACTGGGTTGATAAGGGCTAACTCTAATTTGACTACATGG,QELLCAASLISDRWVLTAAHCLLYPPWDKNFTVNDILVRIGKYARSRYERNMEKISTLEKIIIHPGYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDKQIVTSLLQAGHKGRVTGWGNLKEMWTVNMNEVQPSVLQMVNLPLVERPICKASTGIRVTDNMFCAGYKPEEGKRGDACEGDSGGPFVMKNPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIRKMVDRFG,negative +TCCCCGGAACCTTTCCCTAGCCGAAACAGCCC,MQLPLALCLVCLLVHTAFRVVEGQGWQAFKNDATEIIPELGEYPEPPPELENNKTMNRAENGGRPPHHPFETKDVSEYSCRELHFTRYVTDGPCRSAKPVTELVCSGQCGPARLLPNAIGRGKWWRPSGPDFRCIPDRYRAQRVQLLCPGGEAPRARKVRLVASCKCKRLTRFHNQSELKDFGTEAARPQKGRKPRPRARSAKANQAELENAY,negative +GCUAUCAUCAUUAACUUUAUUUAUUACCGUCAUUCAUUUCUGAAUGUCUGUUUACCCCUAUUUCAACCGGUUUUUUUU,MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYTFLLPEMDNCRSSSSPYVSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQDNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVLVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF,negative +CAGCTCAGAAGCTTGATCCTGTGCGGGCGGCAAGGCCCTGACAGAGATACTGGCTCGGGACTCGAAGTCGTGCATCTGCA,MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPGPHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR,negative +AAAAAGGAGGAGGAGGA,MPSKKNGRSGPQPHKRWVFTLNNPSEDERKKIRELPISLFDYFIVGEEGNEEGRTPHLQGFANFVKKQTFNKVKWYLGARCHIEKAKGTDQQNKEYCSKEGNLLMECGAPRSQGQRSDLSTAVSTLLESGSLVTVAEQHPVTFVRNFRGLAELLKVSGKMQKRDWKTNVHVIVGPPGCGKSKWAANFADPETTYWKPPRNKWWDGYHGEEVVVIDDFYGWLPWDDLLRLCDRYPLTVETKGGTVPFLARSILITSNQTPLEWYSSAAVPAVEALYRRITSLVFWKNATEQSTEEGGQFVTLSPPCPEFPYEINY,negative +GGGAGAGGAGGGAGAUAGAUAUCAAAGCAUAGAUAGGAAUGGCGGCAAGUCACGAACGGUACUGGAACGCACAAGGAGUUUCGUGGAUGCCACAGGAC,MSKRKAPQETLNGGITDMLVELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVTGIGPSAARKLVDEGIKTLEDLRKNEDKLNHHQRIGLKYFEDFEKRIPREEMLQMQDIVLNEVKKLDPEYIATVCGSFRRGAESSGDMDVLLTHPNFTSESSKQPKLLHRVVEQLQKVRFITDTLSKGETKFMGVCQLPSENDENEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEQDIFDYIQWRYREPKDRSE,negative +UCGAAUCGAGUGGAAGUCACUUC,MGVLLTQRTLLSLVLALLFPSMASMAAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQGLDVPKLREHCRERPGAFPSEETLRGLGRRGFLQTLNATLGCVLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILGLRNNIYCMAQLLDNSDTAEPTKAGRGASQPPTPTPASDAFQRKLEGCRFLHGYHRFMHSVGRVFSKWGESPNRSRRHSPHQALRKGVRRTRPSRKGKRLMTRGQLPR,negative +TAATACGACTCACTATAGGGAGACCCAAGCCGATTTATTTTGTGCAGCTTTTGTTCCCTTTAGTGAGGGTTAATT,MKPGGNTIVIWMYAVATWLCFGSTSGWSFTLEDNNIFPKQYPIINFTTAGATVQSYTNFIRAVRGRLTTGADVRHEIPVLPNRVGLPINQRFILVELSNHAELSVTLALDVTNAYVVGYRAGNSAYFFHPDNQEDAEAITHLFTDVQNRYTFAFGGNYDRLEQLAGNLRENIELGNGPLEEAISALYYYSTGGTQLPTLARSFIICIQMISEAARFQYIEGEMRTRIRYNRRSAPDPSVITLENSWGRLSTAIQESNQGAFASPIQLQRRNGSKFSVYDVSILIPIIALMVYRCAPPPSSQFSLLIRPVVPNFNADVCMDPEPIVRIVGRNGLCVDVRDGRFHNGNAIQLWPCKSNTDANQLWTLKRDNTIRSNGKCLTTYGYSPGVYVMIYDCNTAATDATRWQIWDNGTIINPRSSLVLAATSGNSGTTLTVQTNIYAVSQGWLPTNNTQPFVTTIVGLYGLCLQANSGQVWIEDCSSEKAEQQWALYADGSIRPQQNRDNCLTSDSNIRETVVKILSCGPASSGQRWMFKNDGTILNLYSGLVLDVRASDPSLKQIILYPLHGDPNQIWLPLF,negative +TCCCACGCATTCTCCACATCAGTTGAATGGTGTGGTCACTTCCAGTCCCGCAGGGCACACCCTTTCTGTCCTTCCGTCAC,ASFTCLAIWALASAGVVPLVLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAAFFFVPVIISTVCYVSIIRCLSSSAVANRSKK,negative +ATCAACTCACCGTAGGTCTAGTGAGAACTTCAAGTCTACT,MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINYDEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQAVAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQGIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADMDFSALLSQISS,negative +GGGUUCGCUAAGUUGGUCUACCCCUCUCGAAUAUCCGUUA,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +CACUCGUACAUGUCCGUAGUUUUCCCACACUCCC,MQLPLALCLVCLLVHTAFRVVEGQGWQAFKNDATEIIPELGEYPEPPPELENNKTMNRAENGGRPPHHPFETKDVSEYSCRELHFTRYVTDGPCRSAKPVTELVCSGQCGPARLLPNAIGRGKWWRPSGPDFRCIPDRYRAQRVQLLCPGGEAPRARKVRLVASCKCKRLTRFHNQSELKDFGTEAARPQKGRKPRPRARSAKANQAELENAY,negative +CAGAUACAGGCCAUGUGC,MANLGYWLLALFVTMWTDVGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGTWGQPHGGGWGQPHGGSWGQPHGGSWGQPHGGGWGQGGGTHNQWNKPSKPKTNLKHVAGAAAAGAVVGGLGGYMLGSAMSRPMIHFGNDWEDRYYRENMYRYPNQVYYRPVDQYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCVTQYQKESQAYYDGRRSSSTVLFSSPPVILLISFLIFLIVG,negative +CTCCTCTGACTGTAACCACGCAGCCACCAGGAAGATGAATGCTCGAGCAACTCGACGGTCGGCATAGGTAGTCCAGAAGCC,LQENFLPQPRQQHHGTLVLHYRPHREEAGMQHPCLWPGSSHCSDDSTLRRLQCESVTSIGAVCP,negative +GGAGUCUUAGGCAGCGCGUUUUCGAGCUACUCCA,GSNITRVESETKVVILDSFEPLRAETDDAELSVAAECLKKPPKYPPALPIWARPDYNPPLLDRWKAPDYVPPTVHGCALPPQA,negative +UCACCUGUACACUACCUCUACCAUGCUUGAGCCUACGCCGCCGACACCC,MGVLLTQRTLLSLVLALLFPSMASMAAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQGLDVPKLREHCRERPGAFPSEETLRGLGRRGFLQTLNATLGCVLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILGLRNNIYCMAQLLDNSDTAEPTKAGRGASQPPTPTPASDAFQRKLEGCRFLHGYHRFMHSVGRVFSKWGESPNRSRRHSPHQALRKGVRRTRPSRKGKRLMTRGQLPR,negative +ATACCAGCTTATTCAATTCAAGTTGCTGTGGGACAGAAACGGGCGCTAGACTATGCATAGATAGTAAGTGCAATCT,MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP,negative +CCTTCGTTGTCTGCCTTCGTAGCGGATCGAATTACGCGTTAACGGCAACCGATAACGGGACCGATTGCACACCCTTCAGAATTCGCACCA,MAGRSGDSDEELLKAVRLIKFLYQSNPPPNPEGTRQARRNRRRRWRERQRQIHSISERILSTYLGRSAEPVPLQLPPLERLTLDCNEDCGTSGTQGVGSPQILVESPTILESGAKE,negative +CTTCTGCCCGCCTCCTTCCGAGCATTCGTCAGATAGGTGGCAAACAGTTATGGGAACGGGAGACGAGATAGGCGGACACT,MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYTFLLPEMDNCRSSSSPYVSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQDNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVLVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF,negative +GGGAAAAUAAUAAUAAA,MPSNQEARLFLAVLVLAQVLPILVDSAAEKGFKQAFWQPLCQVSEELDDQPKGALFTLQAAASKIQKMRDAALRASIYAEINHGTNRAKAAVIVANHYAMKADSGLEALKQTLSSQEVTATATASYLKGRIDEYLNLLLQTKESGTSGCMMDTSGTNTVTKAGGTIGGVPCKLQLSPIQPKRPAATYLGKAGYVGLTRQADAANNFHDNDAECRLASGHNTNGLGKSGQLSAAVTMAAGYVTVANSQTAVTVQALDALQEASGAAHQPWIDAWKAKKALTGAETAEFRNETAGIAGKTGVTKLVEEALLKKKDSEASEIQTELKKYFSGHENEQWTAIEKLISEQPVAQNLVGDNQPTKLGELEGNAKLTTILAYYRMETAGKFEVLTQKHKPAESQQQAAETEGSCNKKDQNECKSPCKWHNDAENKKCTLDKEEAKKVADETAKDGKTGNTNTTGSSNSFVISKTPLWLAVLLF,negative +GACGGCAACCCGUUAUAACCUCCCACUGGCUAUCCCGUUAAGCUUCCCUA,MSDRKKIEIDAIDKKLLIELLKDSRISLRRLAEEMNVSPATLHNRLMRLVQEGVVKGFTALIDYSKLGYPVTSILMIKVDGKHILEFEKEVSNLDNVVAVYDVVGEYDVMLIAKFRSIEDLDTFIKSLLKNPKIERTYTSIVLNVVKEDPRIKII,negative +GTCTCAATACGCACCCTGCATTCCCTTACTCGAGCCTAGC,MKKTLIALAIAASAASGMAHAWMTGDFNGSVDIGGSITADDYRQKWEWKVGTGLNGFGNVLNDLTNGGTKLTITVTGNKPILLGRTKEAFATPVTGGVDGIPHIAFTDYEGASVVLRNPDGETNKKGLAYFVLPMKNAEGTKVGSVKVNASYAGVLGRGGVTSADGELLSLFADGLSSIFYGGLPRGSELSAGSAAAARTKLFGSLSRNDILGQIQRVNANITSLVDVAGSYRENMEYTDGTVVSAAYALGIANGQTIEATFNQAVTTSTQWSAPLNVAITYY,negative +ACCCCTCTTACCCGAAGCGTTAAGCGGTGGAGGCTGTCA,MGVLLTQRTLLSLVLALLFPSMASMAAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQGLDVPKLREHCRERPGAFPSEETLRGLGRRGFLQTLNATLGCVLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILGLRNNIYCMAQLLDNSDTAEPTKAGRGASQPPTPTPASDAFQRKLEGCRFLHGYHRFMHSVGRVFSKWGESPNRSRRHSPHQALRKGVRRTRPSRKGKRLMTRGQLPR,negative +CCCGUACCACCACACCCUAUGCACAUCGUUGUUUGUCGUCUUUCCCGCAU,MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINYDEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQAVAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQGIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADMDFSALLSQISS,negative +CAGCTCAGAAGCTTGATCCTGTGCAGCCGGGGGACAAGCGCGTTGGCCAGATCATCCGACTCGAAGTCGTGCATCTGCA,MLSWGYFLFLLPTLPGAQSQVQLVESGGDVRKPGDSLRLSCKGSGFTFSNYWLGWVRQAPGKALNGSLPLTPLAAAPTYIPGVSGRFTISRDNARALLHLDMSDLRPEDTGRYHCER,negative +UGACCAAGCCUCACGUUGAACCUGCCAGUAGACCCCGCCCA,MSAPASTTQATGSTTSTTTKTAGATPATASGLFTIPDGDFFSTARAVVASDAVATNEDLSEIEAVWKDMKVPTDTMAQAAWDLVRHCADVGSSAQTEMIDTGPYSNGISRARLAAAIKEVCTLRQFCMKYAPVVWNWMLTNNSPPANWQAQGFKPEHKFAAFDFFNGVTNPAAIMPKEGLIRPPSEAEMNAAQTAAFVKITKARAQSNDFASLDAAVTRGRITGTTTAEAVVTLPPP,negative +ACCGAAAAAGACCUGACUUCUAUACUAAGUCUACGUUCC,MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC,negative +GGGACACAAUGGACGCACCUCCGACGCACAGUCGCAGGCUCGAAAGAGACUAAAUGCUAACGGCCGACAUGAGAG,MLNQLDNLTERVRGSNKLVDRWLHVRKHLLVAYYNLVGIKPGKESYMRLNEKALDDFCQSLVDYLSAGHFSIYERILHKLEGNGQLARAAKIWPQLEANTQQIMDYYDSSLETAIDHDNYLEFQQVLSDIGEALEARFVLEDKLILLVLDAARVKHPA,negative +TCAGACACTTTGCCAAAAAACATGATACAAGTTCGCTGCC,ASFTCLAIWALASAGVVPLVLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAAFFFVPVIISTVCYVSIIRCLSSSAVANRSKK,negative +ATACCAGCTTATTCAATTGACATGACTGGGATTTTTGGCGAAATCGAAGGAAGCGGAGAGATAGTAAGTGCAATCT,MDHLNEATQGKEHSEMSNNVSDPKGPPAKIARLEQNGSPLGRGRLGSTGAKMQGVPLKHSGHLMKTNLRKGTMLPVFCVVEHYENAIEYDCKEEHAEFVLVRKDMLFNQLIEMALLSLGYSHSSAAQAKGLIQVGKWNPVPLSYVTDAPDATVADMLQDVYHVVTLKIQLHSCPKLEDLPPEQWSHTTVRNALKDLLKDMNQSSLAKECPLSQSMISSIVNSTYYANVSAAKCQEFGRWYKHFKKTKDMMVEMDSLSELSQQGANHVNFGQQPVPGNTAEQPPSPAQLSHGSQPSVRTPLPNLHPGLVSTPISPQLVNQQLVMAQLLNQQYAVNRLLAQQSLNQQYLNHPPPVSRSMNKPLEQQVSTNTEVSSEIYQWVRDELKRAGISQAVFARVAFNRTQGLLSEILRKEEDPKTASQSLLVNLRAMQNFLQLPEAERDRIYQDERERSLNAASAMGPAPLISTPPSRPPQVKTATIATERNGKPENNTMNINASIYDEIQQEMKRAKVSQALFAKVAATKSQGWLCELLRWKEDPSPENRTLWENLSMIRRFLSLPQPERDAIYEQESNAVHHHGDRPPHIIHVPAEQIQQQQQQQQQQQQQQQAPPPPQPQQQPQTGPRLPPRQPTVASPAESDEENRQKTRPRTKISVEALGILQSFIQDVGLYPDEEAIQTLSAQLDLPKYTIIKFFQNQRYYLKHHGKLKDNSGLEVDVAEYKEEELLKDLEESVQDKNTNTLFSVKLEEELSVEGNTDINTDLKD,negative +GUUCCAGGCGCGUUAGCAAAACCGCGGAUC,MSKRKAPQETLNGGITDMLVELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVTGIGPSAARKLVDEGIKTLEDLRKNEDKLNHHQRIGLKYFEDFEKRIPREEMLQMQDIVLNEVKKLDPEYIATVCGSFRRGAESSGDMDVLLTHPNFTSESSKQPKLLHRVVEQLQKVRFITDTLSKGETKFMGVCQLPSENDENEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEQDIFDYIQWRYREPKDRSE,negative +AUUUCUCUGAGAUGUUCGCAAGCGGGCCAGUCCCCUGAGCCGAUAUUUCAUACCACAAGAAAUGUGGCGCUCCGCGGUUGGUGAGCAUGCUCGGUCCGUCCGAGAAGCCUUAAAACUGCGACGACACAUUCACCUUGAACCAAGGGUUCAAGGGUUACAGCCUGCGGCGGCAUCUCGGAGAUUCC,MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICEVEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASSIVYKKEGEQVEFSFPLAFTVEKLTGSGELWWQAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLPQALPQYAGSGNLTLALEAKTGKLHQEVNLVVMRATQLQKNLTCEVWGPTSPKLMLSLKLENKEAKVSKREKAVWVLNPEAGMWQCLLSDSGQVLLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQAERMSQIKRLLSEKKTCQCPHRFQKTCSPI,negative +ATACCAGTCTATTCAATTGGGCCCTTTTCTGTGTCTTTCTGTGCCCTTAGATAGTATGTGCAATCA,MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICEVEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASSIVYKKEGEQVEFSFPLAFTVEKLTGSGELWWQAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLPQALPQYAGSGNLTLALEAKTGKLHQEVNLVVMRATQLQKNLTCEVWGPTSPKLMLSLKLENKEAKVSKREKAVWVLNPEAGMWQCLLSDSGQVLLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQAERMSQIKRLLSEKKTCQCPHRFQKTCSPI,negative +AGUCAUUUAUAAGAUCCGACAACCUGUCUAUUAGUUGCGCCGAUUAAGUGACU,WPLTEEKIKALVEICXEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEEFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDXIIYQYMDDLYVGSDLEIGQHRTKVEELRQHLLXWGFTTPDKKHQKEPPFLWMGYELHP,negative +CCGCGCAAGGGGUAACCGGAGAAUAUUUGG,MKPGGNTIVIWMYAVATWLCFGSTSGWSFTLEDNNIFPKQYPIINFTTAGATVQSYTNFIRAVRGRLTTGADVRHEIPVLPNRVGLPINQRFILVELSNHAELSVTLALDVTNAYVVGYRAGNSAYFFHPDNQEDAEAITHLFTDVQNRYTFAFGGNYDRLEQLAGNLRENIELGNGPLEEAISALYYYSTGGTQLPTLARSFIICIQMISEAARFQYIEGEMRTRIRYNRRSAPDPSVITLENSWGRLSTAIQESNQGAFASPIQLQRRNGSKFSVYDVSILIPIIALMVYRCAPPPSSQFSLLIRPVVPNFNADVCMDPEPIVRIVGRNGLCVDVRDGRFHNGNAIQLWPCKSNTDANQLWTLKRDNTIRSNGKCLTTYGYSPGVYVMIYDCNTAATDATRWQIWDNGTIINPRSSLVLAATSGNSGTTLTVQTNIYAVSQGWLPTNNTQPFVTTIVGLYGLCLQANSGQVWIEDCSSEKAEQQWALYADGSIRPQQNRDNCLTSDSNIRETVVKILSCGPASSGQRWMFKNDGTILNLYSGLVLDVRASDPSLKQIILYPLHGDPNQIWLPLF,negative +TCCCTACGGCGCTAACGGATCAAACATGCGCTCCAAGGAGTAGGGGCCACCGTGCTACAAC,WPLTEEKIKALVEICXEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEEFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDXIIYQYMDDLYVGSDLEIGQHRTKVEELRQHLLXWGFTTPDKKHQKEPPFLWMGYELHP,negative +GGGAAUAAUAAUAAUAAAG,MEGMLKGEGPGPLPPLLQQYVELRDQYPDYLLLFQVGDFYECFGEDAERLARALGLVLTHKTSKDFTTPMAGIPLRAFEAYAERLLKMGFRLAVADQVEPAEEAEGLVRREVTQLLTPGTLLQESLLPREANYLAAIATGDGWGLAFLDVSTGEFKGTVLKSKSALYDELFRHRPAEVLLAPELLENGAFLDEFRKRFPVMLSEAPFEPEGEGPLALRRARGALLAYAQRTQGGALSLQPFRFYDPGAFMRLPEATLRALEVFEPLRGQDTLFSVLDETRTAPGRRLLQSWLRHPLLDRGPLEARLDRVEGFVREGALREGVRRLLYRLADLERLATRLELGRASPKDLGALRRSLQILPELRALLGEEVGLPDLSPLKEELEAALVEDPPLKVSEGGLIREGYDPDLDALRAAHREGVAYFLELEERERERTGIPTLKVGYNAVFGYYLEVTRPYYERVPKEYRPVQTLKDRQRYTLPEMKEKEREVYRLEALIRRREEEVFLEVRERAKRQAEALREAARILAELDVYAALAEVAVRYGYVRPRFGDRLQIRAGRHPVVERRTEFVPNDLEMAHELVLITGPNMAGKSTFLRQTALIALLAQVGSFVPAEEAHLPLFDGIYTRIGASDDLAGGKSTFMVEMEEVALILKEATENSLVLLDEVGRGTSSLDGVAIATAVAEALHERRAYTLFATHYFELTALGLPRLKNLHVAAREEAGGLVFYHQVLPGPASKSYGVEVAAMAGLPKEVVARARALLQAMAARREGALDAVLERLLALDPDRLTPLEALRLLQELKALALGAPLDTMKG,negative +AGCTCAGAATGGATCCAAACGCTCATAACTCACTCCATACTCACTTGCTGATTCGCCAACAACACACCCTTAAACAGTCCCTTCGACATGAGAATTCGGCCGGATC,MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQRGLKNVFDEAILAALEPPETQPKRKCCIF,negative +ACACCCACCGCAGGCAGACGCAACGCCTCGGAGACTAGCC,MANLGYWLLALFVTMWTDVGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGTWGQPHGGGWGQPHGGSWGQPHGGSWGQPHGGGWGQGGGTHNQWNKPSKPKTNLKHVAGAAAAGAVVGGLGGYMLGSAMSRPMIHFGNDWEDRYYRENMYRYPNQVYYRPVDQYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCVTQYQKESQAYYDGRRSSSTVLFSSPPVILLISFLIFLIVG,negative +CAGGTCAGTTCAGCGGATCCTGTCGAAAAACACACACCCCGAGGCGAATTCAGTGCAACTGCAGC,MSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEMLDRHHTHFCPLEGESWQDFLRNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAFLCQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERETPTTDSMPPLLRQAIELFDHQGAEPAFLFGLELIICGLEKQLKCESGS,negative +GGGAGAAUUCCGACCAGAAGUUCGAUACGCCGUGGGGUGACGUUGGCUGCCCUUUCCUCUCUCCUCCUUCUUCU,MAAKVASTSSEEAEGSLVTEGEMGEKALPVVYKRYICSFADCGAAYNKNWKLQAHLCKHTGEKPFPCKEEGCEKGFTSLHHLTRHSLTHTGEKNFTCDSDGCDLRFTTKANMKKHFNRFHNIKICVYVCHFENCGKAFKKHNQLKVHQFSHTQQLPYECPHEGCDKRFSLPSRLKRHEKVHAGYPCKKDDSCSFVGKTWTLYLKHVAECHQDLAVCDVCNRKFRHKDYLRDHQKTHEKERTVYLCPRDGCDRSYTTAFNLRSHIQSFHEEQRPFVCEHAGCGKCFAMKKSLERHSVVHDPEKRKLKEKCPRPKRSLASRLTGYIPPKSKEKNASVSGTEKTDSLVKNKPSGTETNGSLVLDKLTIQ,negative +AGGCAGAGAAGAGUGGGUGCGACCACAGGAUGUUAUGG,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,negative +CGCCAGUGUGAAAGAUCCGAAGUUUAUGCCGGCACGCGCUGGCG,MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH,negative +GTCCAGCTAAATCTCTACGAACCCCGCATTCCCCGTAACT,MHGDTPTLHEYMLDLQPETTDLYCYEQLNDSSEEEDEIDGPAGQAEPDRAHYNIVTFCCKCDSTLRLCVQSTHVDIRTLEDLLMGTLGIVCPICSQKP,negative +TCCCACGCATTCTCCACATCATTTGAATAGTGTGGTCACTTCCAGTCCCGCAGGGCACACCCTTTCTGTCCTTCCGTCAC,MQPLLLLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVLTAAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRRNRNVNPVALPRAQEGLRPGTLCTVAGWGRVSMRRGTDTLREVQLRVQRDRQCLRIFGSYDPRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSGVPPEVFTRVSSFLPWIRTTMRSFKLLDQMETPL,negative +GGUUGGGUUGUCGUAGAUAGAGCGCUUCAA,ASFTCLAIWALASAGVVPLVLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAAFFFVPVIISTVCYVSIIRCLSSSAVANRSKK,negative +ATATTCGCGATTATT,MASNFTQFVLVDNGGTGDVTVAPSNFANGVAEWISSNSRSQAYKVTCSVRQSSAQNRKYTIKVEVPKVATQTVGGVELPVAAWRSYLNMELTIPIFATNSDCELIVKAMQGLLKDGNPIPSAIAANSGIY,negative +AATACCCCCCCTTCGGTGCAAAGCACCGAAGGGGGGG,MAVAQELYGFPASKLDSFVAQWLQPTREWKEEVLETVQTVEQFLRQENFREDRGPARDVRVLKVLKVGCFGNGTVLRSTTDVELVVFLSCFHSFQEEAKHHQAVLRLIQKRMYYCQELMDLGLSNLSVTNRVPSSLIFTIQTRETWETITVTVVPAYRALGPSCPSSEVYANLIKANGYPGNFSPSFSELQRNFVKHRPTKLKSLLRLVKHWYQQYVRDKCPRANLPPLYALELLTVYAWEAGTREDANFRLDEGLATVMELLQDHELLCIYWTKHYTLQHPVIEACVRRQLRGQRPIILDPADPTNNVAEGYRWDIVAQRANQCLKQDCCYDNRDSPVPSWRVKRAPDIQVTVQEWGHSDLTFWVNPYEPIKKLKEKIQLSQGYLGLQRLSFQEPGGERQLIRSHCTLAYYGIFCDTHICLLDTISPEIQVFVKNPDGRSHAYAIHPLDYVLNLKQQIEDRQGLRCQEQRLEFQGHILEDWFDFKSYGIQDSVTVILSKTTEGAAPFVPS,negative +CGTACCAAGATCCCACAACTAGCCGACCAGGATTGCCGGC,MASDSIFESFPSYPQCFMRECILGMNPSRDVHDASTSRRFTPPSTALSPGKMSEALPLGAPDAGAALAGKLRSGDRSMVEVLADHPGELARTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFNPQPQSQMQDTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLSTAPSFLFLSNKMLTCKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK,negative +GTCCAGCTAAATCTCTACGAACCCCGCATTCCCCGTAACT,MSAPASTTQATGSTTSTTTKTAGATPATASGLFTIPDGDFFSTARAVVASDAVATNEDLSEIEAVWKDMKVPTDTMAQAAWDLVRHCADVGSSAQTEMIDTGPYSNGISRARLAAAIKEVCTLRQFCMKYAPVVWNWMLTNNSPPANWQAQGFKPEHKFAAFDFFNGVTNPAAIMPKEGLIRPPSEAEMNAAQTAAFVKITKARAQSNDFASLDAAVTRGRITGTTTAEAVVTLPPP,negative +GGCGAAUUCAGGGGACGUAGCAAUGACUGCC,MLDLFADAEPWQEPLAAGAVILRRFAFNAAEQLIRDINDVASQSPFRQMVTPGGYTMSVAMTNCGHLGWTTHRQGYLYSPIDPQTNKPWPAMPQSFHNLCQRAATAAGYPDFQPDACLINRYAPGAKLSLHQDKDEPDLRAPIVSVSLGLPAIFQFGGLKRNDPLKRLLLEHGDVVVWGGESRLFYHGIQPLKAGFHPLTIDCRYNLTFRQAGKKE,negative +CACCTTGCGAAGCATAGTAACACCCAACACGCCCCATGCG,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +TGCAGATGCAAGGTAACCATATCCAAAGCA,MEGMLKGEGPGPLPPLLQQYVELRDQYPDYLLLFQVGDFYECFGEDAERLARALGLVLTHKTSKDFTTPMAGIPLRAFEAYAERLLKMGFRLAVADQVEPAEEAEGLVRREVTQLLTPGTLLQESLLPREANYLAAIATGDGWGLAFLDVSTGEFKGTVLKSKSALYDELFRHRPAEVLLAPELLENGAFLDEFRKRFPVMLSEAPFEPEGEGPLALRRARGALLAYAQRTQGGALSLQPFRFYDPGAFMRLPEATLRALEVFEPLRGQDTLFSVLDETRTAPGRRLLQSWLRHPLLDRGPLEARLDRVEGFVREGALREGVRRLLYRLADLERLATRLELGRASPKDLGALRRSLQILPELRALLGEEVGLPDLSPLKEELEAALVEDPPLKVSEGGLIREGYDPDLDALRAAHREGVAYFLELEERERERTGIPTLKVGYNAVFGYYLEVTRPYYERVPKEYRPVQTLKDRQRYTLPEMKEKEREVYRLEALIRRREEEVFLEVRERAKRQAEALREAARILAELDVYAALAEVAVRYGYVRPRFGDRLQIRAGRHPVVERRTEFVPNDLEMAHELVLITGPNMAGKSTFLRQTALIALLAQVGSFVPAEEAHLPLFDGIYTRIGASDDLAGGKSTFMVEMEEVALILKEATENSLVLLDEVGRGTSSLDGVAIATAVAEALHERRAYTLFATHYFELTALGLPRLKNLHVAAREEAGGLVFYHQVLPGPASKSYGVEVAAMAGLPKEVVARARALLQAMAARREGALDAVLERLLALDPDRLTPLEALRLLQELKALALGAPLDTMKG,negative +TCCCTTCATCATTAACCCGTCCACGCGC,MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYTFLLPEMDNCRSSSSPYVSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQDNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVLVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF,negative +UAUAUAUGUGUGUCUAUCGUCACUUGUAUGUCAAAUAUU,MKTLLLLLLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAKEPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHSRFQPSQSSTYSQPGQSFSIQYGTGSLSGIIGADQVSAFATQVEGLTVVGQQFGESVTEPGQTFVDAEFDGILGLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSHFSGSLNWVPVTKQAYWQIALDNIQVGGTVMFCSEGCQAIVDTGTSLITGPSDKIKQLQNAIGAAPVDGEYAVECANLNVMPDVTFTINGVPYTLSPTAYTLLDFVDGMQFCSSGFQGLDIHPPAGPLWILGDVFIRQFYSVFDRGNNRVGLAPAVP,negative +GGGAGCUCAGCCUUCACUGCACUCCGGCUGGUGGACGCGGUACGAGCAAUUUGUACCGGAUGGAUGUUCGGGCAGCGGUGUGGCAGGGAUGAGCGGCACCACGGUCGGAUCCAC,QSVEESRGGLIKPTDTLTLTCTVSGFSLSSYGEVWDRQAPGNGLEYIGAIGNSGSTYYASWAKSRSTITRNTNLNTVTLKMTSLTAADTATYFCAR,negative +CCTTCGTTGTCTGCCTTCGTAGCGGATCGAATTACGCGTTAACGGCAACCGATAACGGGACCGATTGCACACCCTTCAGAATTCGCACCA,MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC,negative +CGTACCAAGATCCCACAACTAGCCGACCACAATTGCCGGC,WPLTEEKIKALVEICXEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEEFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDXIIYQYMDDLYVGSDLEIGQHRTKVEELRQHLLXWGFTTPDKKHQKEPPFLWMGYELHP,negative +ATACCAGTCTATTCAATTGGGCCCTTTTCTGTGTCTTTCTGTGCCCTTAGATAGTATGTGCAATCA,MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH,negative +CATGACAGAATGTCTGCAGAGCTAATCTTGGTCACTGAT,MQQGQMAYDRAITVFSPDGRLFQVEYAREAVKKGSTALGMKFANGVLLISDKKVRSRLIEQNSIEKIQLIDDYVAAVTSGLVADARVLVDFARISAQQEKVTYGSLVNIENLVKRVADQMQQYTQYGGVRPYGVSLIFAGIDQIGPRLFDCDPAGTINEYKATAIGSGKDAVVSFLEREYKENLPEKEAVTLGIKALKSSLEEGEELKAPEIASITVGNKYRIYDQEEVKKFL,negative +GGGAACUCGAUGAAGCGAAUUCUGUUGGCGAACUGUACGCAAGUACACUGGAUGACAGGCCUAUCUAUCGGAUCCACG,MSARGEEAAGEASGSQEQPEPALAEPKKRGPGRPRKPQQEPTGEPVPKRPRGRPKGSKNKGPSKAAQKKAETTGEKRPRGRPRKWPQQVVQEKPAQEEEEEEEEEEAEED,negative +TCCCACGCATTCTCCACATCATTTGAATAGTGTGGTCACTTCCAGTCCCGCAGGGCACACCCTTTCTGTCCTTCCGTCAC,MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQRGLKNVFDEAILAALEPPETQPKRKCCIF,negative +ATACCAGCTTATTCAATTCCTAATCTTCATGCGTTAATATTTACTGTGCGTTGCTTCGAGATAGTAAGTGCAATCT,MGCRRTREGPSKAMIFPWKCQSTQRDLWNIFKLWGWTMLCCDFLAHHGTDCWTYHYSEKPMNWQRARRFCRDNYTDLVAIQNKAEIEYLEKTLPFSRSYYWIGIRKIGGIWTWVGTNKSLTEEAENWGDGEPNNKKNKEDCVEIYIKRNKDAGKWNDDACHKLKAALCYTASCQPWSCSGHGECVEIINNYTCNCDVGYYGPQCQFVIQCEPLEAPELGTMDCTHPLGNFSFSSQCAFSCSEGTNLTGIEETTCGPFGNWSSPEPTCQVIQCEPLSAPDLGIMNCSHPLASFSFTSACTFICSEGTELIGKKKTICESSGIWSNPSPICQKLDKSFSMIKEGDYNPLFIPVAVMVTAFSGLAFIIWLARRLKKGM,negative +CAAAACGTGGATTGGGTCAAATGAGTCGTTTTTC,MPFVNKQFNYKDPVNGVDIAYIKIPNVGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAGHRLYGIAINPNRVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNRKTYLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLKNFTGLFEFYKLLCVRGIITSKTKSLDKGYNKALNDLCIKVNNWDLFFSPSEDNFTNDLNKGEEITSDTNIEAAEENISLDLIQQYYLTFNFDNEPENISIENLSSDIIGQLELMPNIERFPNGKKYELDKYTMFHYLRAQEFEHGKSRIALTNSVNEALLNPSRVYTFFSSDYVKKVNKATEAAMFLGWVEQLVYDFTDETSEVSTTDKIADITIIIPYIGPALNIGNMLYKDDFVGALIFSGAVILLEFIPEIAIPVLGTFALVSYIANKVLTVQTIDNALSKRNEKWDEVYKYIVTNWLAKVNTQIDLIRKKMKEALENQAEATKAIINYQYNQYTEEEKNNINFNIDDLSSKLNESINKAMININKFLNQCSVSYLMNSMIPYGVKRLEDFDASLKDALLKYIYDNRGTLIGQVDRLKDKVNNTLSTDIPFQLSKYVDNQRLLSTFTEYIKNIINTSILNLRYESNHLIDLSRYASKINIGSKVNFDPIDKNQIQLFNLESSKIEVILKNAIVYNSMYENFSTSFWIRIPKYFNSISLNNEYTIINCMENNSGWKVSLNYGEIIWTLQDTQEIKQRVVFKYSQMINISDYINRWIFVTITNNRLNNSKIYINGRLIDQKPISNLGNIHASNNIMFKLDGCRDTHRYIWIKYFNLFDKELNEKEIKDLYDNQSNSGILKDFWGDYLQYDKPYYMLNLYDPNKYVDVNNVGIRGYMYLKGPRGSVMTTNIYLNSSLYRGTKFIIKKYASGNKDNIVRNNDRVYINVVVKNKEYRLATNASQAGVEKILSALEIPDVGNLSQVVVMKSKNDQGITNKCKMNLQDNNGNDIGFIGFHQFNNIAKLVASNWYNRQIERSSRTLGCSWEFIPVDDGWGERPL,negative +GCAAUGGUACGGUACUUCCAAGUGCGGGGGGGAGGUGGUGGUUCCAAAAGUGCACGCUACUUUGCUAA,MQLPLALCLVCLLVHTAFRVVEGQGWQAFKNDATEIIPELGEYPEPPPELENNKTMNRAENGGRPPHHPFETKDVSEYSCRELHFTRYVTDGPCRSAKPVTELVCSGQCGPARLLPNAIGRGKWWRPSGPDFRCIPDRYRAQRVQLLCPGGEAPRARKVRLVASCKCKRLTRFHNQSELKDFGTEAARPQKGRKPRPRARSAKANQAELENAY,negative +AGAAAAAAACAAUCCACAGAACAGCGCGUG,MAVAQELYGFPASKLDSFVAQWLQPTREWKEEVLETVQTVEQFLRQENFREDRGPARDVRVLKVLKVGCFGNGTVLRSTTDVELVVFLSCFHSFQEEAKHHQAVLRLIQKRMYYCQELMDLGLSNLSVTNRVPSSLIFTIQTRETWETITVTVVPAYRALGPSCPSSEVYANLIKANGYPGNFSPSFSELQRNFVKHRPTKLKSLLRLVKHWYQQYVRDKCPRANLPPLYALELLTVYAWEAGTREDANFRLDEGLATVMELLQDHELLCIYWTKHYTLQHPVIEACVRRQLRGQRPIILDPADPTNNVAEGYRWDIVAQRANQCLKQDCCYDNRDSPVPSWRVKRAPDIQVTVQEWGHSDLTFWVNPYEPIKKLKEKIQLSQGYLGLQRLSFQEPGGERQLIRSHCTLAYYGIFCDTHICLLDTISPEIQVFVKNPDGRSHAYAIHPLDYVLNLKQQIEDRQGLRCQEQRLEFQGHILEDWFDFKSYGIQDSVTVILSKTTEGAAPFVPS,negative +GGUCCGUAGUUCUGGCUGACUGGUUACCCGGUCGUACAGCUCG,MAVAQELYGFPASKLDSFVAQWLQPTREWKEEVLETVQTVEQFLRQENFREDRGPARDVRVLKVLKVGCFGNGTVLRSTTDVELVVFLSCFHSFQEEAKHHQAVLRLIQKRMYYCQELMDLGLSNLSVTNRVPSSLIFTIQTRETWETITVTVVPAYRALGPSCPSSEVYANLIKANGYPGNFSPSFSELQRNFVKHRPTKLKSLLRLVKHWYQQYVRDKCPRANLPPLYALELLTVYAWEAGTREDANFRLDEGLATVMELLQDHELLCIYWTKHYTLQHPVIEACVRRQLRGQRPIILDPADPTNNVAEGYRWDIVAQRANQCLKQDCCYDNRDSPVPSWRVKRAPDIQVTVQEWGHSDLTFWVNPYEPIKKLKEKIQLSQGYLGLQRLSFQEPGGERQLIRSHCTLAYYGIFCDTHICLLDTISPEIQVFVKNPDGRSHAYAIHPLDYVLNLKQQIEDRQGLRCQEQRLEFQGHILEDWFDFKSYGIQDSVTVILSKTTEGAAPFVPS,negative +GGTTGGTGTGGTTGG,MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC,negative +CAGCUAGAGGCAAAGUGGUCUCGACGUAGGGGGACCUGCUCGCUG,MLNQLDNLTERVRGSNKLVDRWLHVRKHLLVAYYNLVGIKPGKESYMRLNEKALDDFCQSLVDYLSAGHFSIYERILHKLEGNGQLARAAKIWPQLEANTQQIMDYYDSSLETAIDHDNYLEFQQVLSDIGEALEARFVLEDKLILLVLDAARVKHPA,negative +GGGAGAGGAGAGAACGUUCUACCUUGCCUAACAGGAGGUGGAGUAUUGGACCCGCUGUCGAUCGAUCGAUCGAUG,MTVFLSFAFLAAILTHIGCSNQRRSPENSGRRYNRIQHGQCAYTFILPEHDGNCRESTTDQYNTNALQRDAPHVEPDFSSQKLQHLEHVMENYTQWLQKLENYIVENMKSEMAQIQQNAVQNHTATMLEIGTSLLSQTAEQTRKLTDVETQVLNQTSRLEIQLLENSLSTYKLEKQLLQQTNEILKIHEKNSLLEHKILEMEGKHKEELDTLKEEKENLQGLVTRQTYIIQELEKQLNRATTNNSVLQKQQLELMDTVHNLVNLCTKEGVLLKGGKREEEKPFRDCADVYQAGFNKSGIYTIYINNMPEPKKVFCNMDVNGGGWTVIQHREDGSLDFQRGWKEYKMGFGNPSGEYWLGNEFIFAITSQRQYMLRIELMDWEGNRAYSQYDRFHIGNEKQNYRLYLKGHTGTAGKQSSLILHGADFSTKDADNDNCMCKCALMLTGGWWFDACGPSNLNGMFYTAGQNHGKLNGIKWHYFKGPSYSLRSTTMMIRPLDF,negative +CGCACTGAAGTGGGATACCGCCTAAACGG,MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICEVEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASSIVYKKEGEQVEFSFPLAFTVEKLTGSGELWWQAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLPQALPQYAGSGNLTLALEAKTGKLHQEVNLVVMRATQLQKNLTCEVWGPTSPKLMLSLKLENKEAKVSKREKAVWVLNPEAGMWQCLLSDSGQVLLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQAERMSQIKRLLSEKKTCQCPHRFQKTCSPI,negative +GAAGCUUACAAGAAGGACAGCACGAAUAAAACCUGCGUAAAUCCGCCCCAUUUGUGUAAGGGUAGUGGGUCGAAUUCCGCUCA,PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGKISKIGPENPYNTPVFAIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDESFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPXRXKNPEMVIYQYMDDLYVGSDLEIGQHRAKIEELRSHLLSWGFTTPDKKHQKEPPFLWMGYELHPDSWTVQPIELPEKDSWTVNE,negative +GGGAGAGGAGGGAGAUAGAUAUCAAGAUAAAAACGCCGGCGUAGCGCUGCAGCGCAAAAAAACACGACUGCUCGCACGAGGUGACUCAGGCAGAGAAGGCGAGUUUCGUGGAUGCCACAGGAC,GLVKKAHEISVLCDAELALIIFSPKGKLYEYATDSKMEIILERYERYTYAEKALIASDPDVQGNWCHEYIKLKAKFEALNKSQRHLMGEQLDTLNQKELLQLETKLEGSLKNVRSRKTQLMLDSISELQEKGKSLQEQNTCLEKEILGKQKDKAPKQHVQWEKQNQPPPTSSAPMPFLIGDIHPTPNIRNFQGRTVADA,negative +GGGAGGACGATGCGGTGACGTAAGAGTGTAATCGATGCAGCCTGGCAGACGACGAGCGGGA,MLNQLDNLTERVRGSNKLVDRWLHVRKHLLVAYYNLVGIKPGKESYMRLNEKALDDFCQSLVDYLSAGHFSIYERILHKLEGNGQLARAAKIWPQLEANTQQIMDYYDSSLETAIDHDNYLEFQQVLSDIGEALEARFVLEDKLILLVLDAARVKHPA,negative +GGCAGCGAAAGCGGAACAAGUAUGUAACCAUGCCUCGGCAACUUUACAUGCGUAGCCAAACCCA,MDKLVVNYYEYKHPIINKDLAIGAHGGKKFPTLGAWYDVINEYEFQTRCPIILKNSHRNKHFTFACHLKNCPFKVLLSYAGNAASSETSSPSANNNTNPPGTPDHIHHHSNNMNNEDNDNNNGSNNKVSNDSKLDFVTDDLEYHLANTHPDDTNDKVESRSNEVNGNNDDDADANNIFKQQGVTIKNDTEDDSINKASIDRGLDDESGPTHGNDSGNHRHNEEDDVHTQMTKNYSDVVNDEDINVAIANAVANVDSQSNNKHDGKDDDATNNNDGQDNNTNNDHNNNSNINNNNVGSHGISSHSPSSIRDTSMNLDVFNSATDDIPGPFVVTKIEPYHSHPLEDNLSLGKFILTKIPKILQNDLKFDQILESSYNNSNHTVSKFKVSHYVEESGLLDILMQRYGLTAEDFEKRLLSQIARRITTYKARFVLKKKKMGEYNDLQPSSSSNNNNNNDGELSGTNLRSNSIDYAKHQEISSAGTSSNTTKNVNNNKNDSNDDNNGNNNNDASNLMESVLDKTSSHRYQPKKMPSVNKWSKPDQITHSDVSMVGLDESNDGGNENVHPTLAEVDAQEARETAQLAIDKINSYKRSIDDKNGDGHNNSSRNVVDENLINDMDSEDAHKSKRQHLSDITLEERNEDDKLPHEVAEQLRLLSSHLKEVENLHQNNDDDVDDVMVDVDVESQYNKNTTHHNNHHSQPHHDEEDVAGLIGKADDEEDLSDENIQPELRGQ,negative +TCTCATGCGTCGAGTGTGAGTTTACCTTCGT,MASNFTQFVLVDNGGTGDVTVAPSNFANGVAEWISSNSRSQAYKVTCSVRQSSAQNRKYTIKVEVPKVATQTVGGVELPVAAWRSYLNMELTIPIFATNSDCELIVKAMQGLLKDGNPIPSAIAANSGIY,negative +ACCUUCUGUUCAUAUCGUGACCAACCCAAUAGAUUGUGAUAAAGGAGGAGGAGGA,MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYTFLLPEMDNCRSSSSPYVSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQDNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVLVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF,negative +CAGCTCAGAAGCTTGATCCTGTGCGATCGAATGAAAGCTGCTGGATTGTCGCTATCCTGACTCGAAGTCGTGCATCTGCA,MLSWGYFLFLLPTLPGAQSQVQLVESGGDVRKPGDSLRLSCKGSGFTFSNYWLGWVRQAPGKALNGSLPLTPLAAAPTYIPGVSGRFTISRDNARALLHLDMSDLRPEDTGRYHCER,negative +AGGACUGAAAUAUUCACGUUGACGUUGUCUUGGAGUGCUGAUCGGAAAACCAAUAUGAUUAAGGGUCCUG,MSSSQKKAGGKAGKPTKRSQNYAALRKAQLPKPPALKVPVVKPTNTILPQTGCVWQSLGTPLSLSSFNGLGARFLYSFLKDFVGPRILEEDLIYRMVFSITPSHAGTFCLTDDVTTEDGRAVAHGNPMQEFPHGAFHANEKFGFELVFTAPTHAGMQNQNFKHSYAVALCLDFDAQPEGSKNPSFRFNEVWVERKAFPRAGPLRSLITVGLFDEADDLDRH,negative +AACUAGCAGGCAGAGAAGAGUGGGUGCGACCACAGGAUGUUAUGGCCUG,MDKFWWHAAWGLCLVPLSLAQIDLNITCRFAGVFHVEKNGRYSISRTEAADLCKAFNSTLPTMAQMEKALSIGFETCRYGFIEGHVVIPRIHPNSICAANNTGVYILTSNTSQYDTYCFNASAPPEEDCTSVTDLPNAFDGPITITIVNRDGTRYVQKGEYRTNPEDIYPSNPTDDDVSSGSSSERSSTSGGYIFYTFSTVHPIPDEDSPWITDSTDRIPATTLMSTSATATETATKRQETWDWFSWLFLPSESKNHLHTTTQMAGTSSNTISAGWEPNEENEDERDRHLSFSGSGIDDDEDFISSTISTTPRAFDHTKQNQDWTQWNPSHSNPEVLLQTTTRMTDVDRNGTTAYEGNWNPEAHPPLIHHEHHEEEETPHSTSTIQATPSSTTEETATQKEQWFGNRWHEGYRQTPKEDSHSTTGTAAASAHTSHPMQGRTTPSPEDSSWTDFFNPISHPMGRGHQAGRRMDMDSSHSITLQPTANPNTGLVEDLDRTGPLSMTTQQSNSQSFSTSHEGLEEDKDHPTTSTLTSSNRNDVTGGRRDPNHSEGSTTLLEGYTSHYPHTKESRTFIPVTSAKTGSFGVTAVTVGDSNSNVNRSLSGDQDTFHPSGGSHTTHGSESDGHSHGSQEGGANTTSGPIRTPQIPEWLIILASLLALALILAVCIAVNSRRRCGQKKKLVINSGNGAVEDRKPSGLNGEASKSQEMVHLVNKESSETPDQFMTADETRNLQNVDMKIGV,negative +ACAAAUCCCCAGGAGUGCAAUACUCCGCAA,MVMGLGVLLLVFVLGLGLTPPTLAQDNSRYTHFLTQHYDAKPQGRDDRYCESIMRRRGLTSPCKDINTFIHGNKRSIKAICENKNGNPHRENLRISKSSFQVTTCKLHGGSPWPPCQYRATAGFRNVVVACENGLPVHLDQSIFRRP,negative +UAUAUAUGUGUGUCUAUCGUCACUUGUAUGUCAAAUAUU,AKVLVVLLLFAGVDAETHVTGGSAAHAASTFAGLFSPGAKQDIQLINTNGSWHINRTA,negative +GGCGACCCCCGGGCTACCAGACAATGTACGCAGCAAGAGTGACGGTCGTACCTCGGAGTC,MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYTFLLPEMDNCRSSSSPYVSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQDNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVLVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF,negative +GGGCGAAUUCGAGCCUCAAGACGUCGGGGAUUGGCAAACCCCGUUUCCUUGAGCGACCCCCUGUUACUCGGCGGAUCCUCU,MTSHYVIAIFALMSSCLATAGPEPGALCELSPVSASHPVQALMESFTVLSGCASRGTTGLPQEVHVLNLRTAGQGPGQLQREVTLHLNPISSVHIHHKSVVFLLNSPHPLVWHLKTERLATGVSRLFLVSEGSVVQFSSANFSLTAETEERNFPHGNEHLLNWARKEYGAVTSFTELKIARNIYIKVGEDQVFPPKCNIGKNFLSLNYLAEYLQPKAAEGCVMSSQPQNEEVHIIELITPNSNPYSAFQVDITIDIRPSQEDLEVVKNLILILKCKKSVNWVIKSFDVKGSLKIIAPNSIGFGKESERSMTMTKSIRDDIPSTQGNLVKWALDNGYSPITSYTMAPVANRFHLRLENNAEEMGDEEVHTIPPELRILLDPGALPALQNPPIRGGEGQNGGLPFPFPDISRRVWNEEGEDGLPRPKDPVIPSIQLFPGLREPEEVQGSVDIALSVKCDNEKMIVAVEKDSFQASGYSGMDVTLLDPTCKAKMNGTHFVLESPLNGCGTRPRWSALDGVVYYNSIVIQVPALGDSSGWPDGYEDLESGDNGFPGDMDEGDASLFTRPEIVVFNCSLQQVRNPSSFQEQPHGNITFNMELYNTDLFLVPSQGVFSVPENGHVYVEVSVTKAEQELGFAIQTCFISPYSNPDRMSHYTIIENICPKDESVKFYSPKRVHFPIPQADMDKKRFSFVFKPVFNTSLLFLQCELTLCTKMEKHPQKLPKCVPPDEACTSLDASIIWAMMQNKKTFTKPLAVIHHEAESKEKGPSMKEPNPISPPIFHGLDTLTVMGIAFAAFVIGALLTGALWYIYSHTGETAGRQQVPTSPPASENSSAAHSIGSTQSTPCSSSSTA,negative +GAACGACCACCGCTACCGACTACGCCATAAACTGCCCGG,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +CCCGGUUACCGUGUUUGUUCUGCUAGAUUUUGGUU,QELLCAASLISDRWVLTAAHCLLYPPWDKNFTVNDILVRIGKYARSRYERNMEKISTLEKIIIHPGYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDKQIVTSLLQAGHKGRVTGWGNLKEMWTVNMNEVQPSVLQMVNLPLVERPICKASTGIRVTDNMFCAGYKPEEGKRGDACEGDSGGPFVMKNPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIRKMVDRFG,negative +GGGCUAGCUGAUCGUACCAGUAGCGUGGCCUGGGGGGCCUAGUCGUGCGAUACUAACAGCUAACACCC,MLDLFADAEPWQEPLAAGAVILRRFAFNAAEQLIRDINDVASQSPFRQMVTPGGYTMSVAMTNCGHLGWTTHRQGYLYSPIDPQTNKPWPAMPQSFHNLCQRAATAAGYPDFQPDACLINRYAPGAKLSLHQDKDEPDLRAPIVSVSLGLPAIFQFGGLKRNDPLKRLLLEHGDVVVWGGESRLFYHGIQPLKAGFHPLTIDCRYNLTFRQAGKKE,negative +GGAGUCUUAGGCAGCGCGUUUUCGAGCUACUCCA,MARVRGPRLPGCLALAALFSLVHSQHVFLAHQQASSLLQRARRANKGFLEEVRKGNLERECLEEPCSREEAFEALESLSATDAFWAKYTACESARNPREKLNECLEGNCAEGVGMNYRGNVSVTRSGIECQLWRSRYPHKPEINSTTHPGADLRENFCRNPDGSITGPWCYTTSPTLRREECSVPVCGQDRVTVEVIPRSGGSTTSQSPLLETCVPDRGREYRGRLAVTTSGSRCLAWSSEQAKALSKDQDFNPAVPLAENFCRNPDGDEEGAWCYVADQPGDFEYCDLNYCEEPVDGDLGDRLGEDPDPDAAIEGRTSEDHFQPFFNEKTFGAGEADCGLRPLFEKKQVQDQTEKELFESYIEGRIVEGQDAEVGLSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTVDDLLVRIGKHSRTRYERKVEKISMLDKIYIHPRYNWKENLDRDIALLKLKRPIELSDYIHPVCLPDKQTAAKLLHAGFKGRVTGWGNRRETWTTSVAEVQPSVLQVVNLPLVERPVCKASTRIRITDNMFCAGYKPGEGKRGDACEGDSGGPFVMKSPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDRLGS,negative +CUCUUUUUGUCCCCGCACGUUGAACUCCUGUCCCUCUACU,MKPGGNTIVIWMYAVATWLCFGSTSGWSFTLEDNNIFPKQYPIINFTTAGATVQSYTNFIRAVRGRLTTGADVRHEIPVLPNRVGLPINQRFILVELSNHAELSVTLALDVTNAYVVGYRAGNSAYFFHPDNQEDAEAITHLFTDVQNRYTFAFGGNYDRLEQLAGNLRENIELGNGPLEEAISALYYYSTGGTQLPTLARSFIICIQMISEAARFQYIEGEMRTRIRYNRRSAPDPSVITLENSWGRLSTAIQESNQGAFASPIQLQRRNGSKFSVYDVSILIPIIALMVYRCAPPPSSQFSLLIRPVVPNFNADVCMDPEPIVRIVGRNGLCVDVRDGRFHNGNAIQLWPCKSNTDANQLWTLKRDNTIRSNGKCLTTYGYSPGVYVMIYDCNTAATDATRWQIWDNGTIINPRSSLVLAATSGNSGTTLTVQTNIYAVSQGWLPTNNTQPFVTTIVGLYGLCLQANSGQVWIEDCSSEKAEQQWALYADGSIRPQQNRDNCLTSDSNIRETVVKILSCGPASSGQRWMFKNDGTILNLYSGLVLDVRASDPSLKQIILYPLHGDPNQIWLPLF,negative +GCATGAATTCCCGAAGACGCAAACTGAAGAGGCACCGAAGGGGGGG,MKKRKVLIPLMALSTILVSSTGNLEVIQAEVKQENRLLNESESSSQGLLGYYFSDLNFQAPMVVTSSTTGDLSIPSSELENIPSENQYFQSAIWSGFIKVKKSDEYTFATSADNHVTMWVDDQEVINKASNSNKIRLEKGRLYQIKIQYQRENPTEKGLDFKLYWTDSQNKKEVISSDNLQLPELKQKSSNSRKKRSTSAGPTVPDRDNDGIPDSLEVEGYTVDVKNKRTFLSPWISNIHEKKGLTKYKSSPEKWSTASDPYSDFEKVTGRIDKNVSPEARHPLVAAYPIVHVDMENIILSKNEDQSTQNTDSQTRTISKNTSTSRTHTSEVHGNAEVHASFFDIGGSVSAGFSNSNSSTVAIDHSLSLAGERTWAETMGLNTADTARLNANIRYVNTGTAPIYNVLPTTSLVLGKNQTLATIKAKENQLSQILAPNNYYPSKNLAPIALNAQDDFSSTPITMNYNQFLELEKTKQLRLDTDQVYGNIATYNFENGRVRVDTGSNWSEVLPQIQETTARIIFNGKDLNLVERRIAAVNPSDPLETTKPDMTLKEALKIAFGFNEPNGNLQYQGKDITEFDFNFDQQTSQNIKNQLAELNATNIYTVLDKIKLNAKMNILIRDKRFHYDRNNIAVGADESVVKEAHREVINSSTEGLLLNIDKDIRKILSGYIVEIEDTEGLKEVINDRYDMLNISSLRQDGKTFIDFKKYNDKLPLYISNPNYKVNVYAVTKENTIINPSENGDTSTNGIKKILIFSKKGYEIG,negative +GTAAATCGTCGACAGGAATTGGCGGGCCGG,ASFTCLAIWALASAGVVPLVLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAAFFFVPVIISTVCYVSIIRCLSSSAVANRSKK,negative +CTTCTGCCCGCCTCCTTCCTTCTTGAATTTTGAGATGAGGTCACTAGGTCCTTCGCGGGGAGACGAGATAGGCGGACACT,PHITDVVLDKANKTPLRQLDPSRLPDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFAKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRQSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPINRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDTASEATRPATLNRFSALQQTLPAENTDNRRVVQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRTRTPATKRSFSKEVEERSRERPSQPEGLRKAASLTEDRGRDPVKREATLPPVSPPKAALSVDEVEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRLGIESTLERSTIAREHMGRLLHQLLCAGHLSTAQYYQGLYETLELAEDMEIDIPHVWLYLAELITPILQEDGVPMGELFREITKPLRPMGKATSLLLEILGLLCKSMGPKKVGMLWREAGLSWREFLAEGQDVGSFVAEKKVEYTLGEESEAPGQRTLAFEELRRQLEKLLKDGGSNQRVFDWIDANLNEQQIASNTLVRALMTTVCYSAIIFETPLRVDVQVLKVRARLLQKYLCDEQKELQALYALQALVVTLEQPANLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFNWLREAEDEESDHN,negative +GCCCUCCAACCACACCCCGCCAACAACCCC,VVIRSNNFTDNAKTIIVQLNESIAINCTRPNNNTRKSIHIGPGRAFYTTGDIIGNIRQAHCNLSRTKWENTLKQIAKKLREQFGNKTIVFNH,negative +TAGGGAATTCGTCGACGGATCCATCCTCAAAGGTTGGACACACATCAATAATAATTGTTCTTGTGGGCTCGCGCGGCGCATGCGTCGACCTGGAG,MKQYLNTVISNPRPAQALGINQPFVVFCFITSRALSFVPAIYWCFKCLHLAFVADKFKWLPLTSALWTLVSAYLSFVLANGFLLKWLIHYSIGPTIIRLFSLNVINFSFLSLSVSFITHGDNAYLLPAWIAISCFQTAAYIVQDWITSPIIRTLPFRSSSSSSSNYRHNLDFLEITVFAVVPVGIASFFTMVMLIWQLYKYPDSFLVSA,negative +ACTACACGAGGACCTACGACTACTACATTATGCCAACCGGTCTTGCTTCGACACAGATACCTC,RRIKRLEQEKLELSRKLQESTQTVQALQYSTVDGPLTASKDLEIKNLKEEIEKLRKQVTESSHLEQQLEEANAVRQELDDAFRQIKAYEKQIKTLQQEREDLNKELVQASERLKNQSKELKDAHCQRKLAMQEFMEINER,negative +GGUAGAUACGAUGGAGGUGUAUUUUAUGUGCGUAUUUGGAGGCAUGACGCGCAGCCA,MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYTFLLPEMDNCRSSSSPYVSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQDNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVLVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF,negative +AGUCAUUUAUAAGAUCCGACAACCUGUCUAUUAGUUGCGCCGAUUAAGUGACU,MKPGGNTIVIWMYAVATWLCFGSTSGWSFTLEDNNIFPKQYPIINFTTAGATVQSYTNFIRAVRGRLTTGADVRHEIPVLPNRVGLPINQRFILVELSNHAELSVTLALDVTNAYVVGYRAGNSAYFFHPDNQEDAEAITHLFTDVQNRYTFAFGGNYDRLEQLAGNLRENIELGNGPLEEAISALYYYSTGGTQLPTLARSFIICIQMISEAARFQYIEGEMRTRIRYNRRSAPDPSVITLENSWGRLSTAIQESNQGAFASPIQLQRRNGSKFSVYDVSILIPIIALMVYRCAPPPSSQFSLLIRPVVPNFNADVCMDPEPIVRIVGRNGLCVDVRDGRFHNGNAIQLWPCKSNTDANQLWTLKRDNTIRSNGKCLTTYGYSPGVYVMIYDCNTAATDATRWQIWDNGTIINPRSSLVLAATSGNSGTTLTVQTNIYAVSQGWLPTNNTQPFVTTIVGLYGLCLQANSGQVWIEDCSSEKAEQQWALYADGSIRPQQNRDNCLTSDSNIRETVVKILSCGPASSGQRWMFKNDGTILNLYSGLVLDVRASDPSLKQIILYPLHGDPNQIWLPLF,negative +UAAGCUCUUUGGCUUAGCCCGACACGUUGAACUCCAGAGU,VFTDNSSPPAVPQSFQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGFGAYMSKAHGVDPNIRTGVRTITTGSPITYSTYGKFLADGGCSGGAYDIIICDECHSTDATSILGIGTVLDQAETAGARLVVLATATPPGSVTVSHPNIEEVALSTTGEIPFYGKAIPLEVIKGGRHLIFCHSKKKCDELAAKLVALGINAVAYYRGLDVSVIPTSGDVVVVSTDALMTGFTGDFDSVIDCNTCVTQTVDFSLDPTFTIETTTLPQDAVSRTQRRGRTGRGKPGIYRFVAPGERPSGMFDSSVLCECYDAGCAWYELTPAETTVRLRAYMNTPGLPVCQDHLEFWEGVFTGLTHIDAHFLSQTKQSGENFPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPTLHGPTPLLYRLGAVQNEVT,negative +UAAACCUGCUGGCAGUGUGACCUAAGGACCAAGCCGUUCCUGAGGAACGUC,MAIPKELLVLLLGIAILSKVAECAAFGSRRGLVETVFDVTRFGARPNTPADSTRGLMMAWRSACQSPGPAKVVIPPGTYTTGETIFQGPCTSPRPITIEIQGTLLSNTDMSLYTRAAWISIEHVDGIVITGGGTLNGQGKSSWQFADKSGSTPPLPSSLVFQTVRSSSIKNLNFVDAKGVHLKITDSSDISVSNIKITAPGDSPNTDGLHISDTINVNVTDSTIGTGDDCISIGDGNSNVYISNINCGPGHGISIGSLGKRLDETDVKGVTVRNCTFRGTTNGARIKTYMGSPSLQVSGVVYEDIILDNVKNPIVIDQHYHSKNRNEPSRVKLVDIHFRNIRGTTTSKIPVLLNCSEALPCEGVELVDIDLAPVGSIGPLLPATCQNAKTILNGKNNPPAC,negative +AGCGACTGACGATCTTGAGTAAACCGCTCATCCACGTAGT,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,negative +UCCCUGGCCCAAGAUCCUAAUAAAGUUUUUUCGGACCGGAGCGAAACCACUAUCCUCUUAAGCAAUCUGU,MPEEWVRIFGEAGITQFEQQRNPRLCLSVLNILSKSEHPQEKFMFVPYEQSALPVTDNSPFGDTSITHNYADHHFKASTPENEGSSFYSRVPGPCTVGVRSSSLSSGRGSSEGVGSRSGSGSGGAASRSSSSGHGGAGFPLPVTSVPANGRSSAPGPNSMTVTSGSHSSSGSNCSTGSLTGGMELTNTMVATTQRTGPNNVLVNGHSTGNHFHGGVTQRVAASAAPTECNVLPTYTGSSSSYQPTSFQSMAVHTPPAYTLRQIPPAHSIGYPYTSTAPTSESIILTAPTTTPSSTVYHTTQGSAIVKPLSDNQSQRDKLPYLMHKSQWHSNVTGHVPLSPGLPRRFVDGVLPPETSAHIQYSSGQSSPSPAGSATPVPTPRRESLAGSVPVRAGPAPPALATHELSSDANCTLTPPPVATRPEKTKSIYTKPVEAQCDGHLTIGDQQDASRRSLETPVPPQTAATIHGSENETRTNVTVLPTVHSDGNNSSVHAYQQATESRPLKPNTLERQGQKKVRPKISDEAIQEKLRMIVSIGDPNRKYQRQEKIGQGASGTVYGGIEVATGRRVAIKQMNLKQQPKKELIVNEIYVMKAKKHPNVVNYLDSYLVADELWVVMEYLDGGSLTEVVTETYMEEGQIAAVCRECLQALDFLHKNQVIHRDIKSDNILLGLDGSVKLTDFGFCAQLSSEQNKRSTMVGTPYWMAPEVVTRKQYGPKVDIWSLGIMAIEMLDGEPPYLNENPVRALYLIGTNGKPEIKERDKLSSEFQDFLDLCLEVKVERRATAQELLQHIFSRDGHRAMELLQTDNFHSSGVRKKRTPRLAIEKLVDPEVKRNYQNQLVECLPDGTVSDINGHWEKISKALLKPRRTVVMAAGEDELVVTVRGTSFNCPPTSLVEPNTGIIAPLIEPHHRGIGSYALEVVADIIGTLDYCGIAFLTMGSFVPYLYYSFYCVLWLKLFYLALIFALGSGAIAVSMSNTFASPAYRPLRALVFIALGLSGVIPCVHVTITNGFWPSLQHGSLGWLFLMAVLYITGASIYAVRVPERIFPGRFDIWFQSHQIFHVFVVAAALVHYHGIIGLTNYRLAIGDCRPPPGYPFPKHDYDNIELLRPFMTY,negative +CACGGTAGTGCTACCAGATGGTTATGTTACTTCAATTCTG,PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGKISKIGPENPYNTPVFAIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDESFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPXRXKNPEMVIYQYMDDLYVGSDLEIGQHRAKIEELRSHLLSWGFTTPDKKHQKEPPFLWMGYELHPDSWTVQPIELPEKDSWTVNE,negative +GGGAAUAAUAAUAAUAAAG,MHGDTPTLHEYMLDLQPETTDLYCYEQLNDSSEEEDEIDGPAGQAEPDRAHYNIVTFCCKCDSTLRLCVQSTHVDIRTLEDLLMGTLGIVCPICSQKP,negative +UGUAGUUUCCCUGUAUGC,WPLTEEKIKALVEICXEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEEFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDXIIYQYMDDLYVGSDLEIGQHRTKVEELRQHLLXWGFTTPDKKHQKEPPFLWMGYELHP,negative +GAAUCAAUACACAGUCCUGGGUGCUAACCAUGAACACCCAAGGCCUUAGUGGUGUGUGGUCCCUG,MDSTNYISKLFEYAQRQGQISDIKFEEVGTDGPDHLKTFTLRVVIKGHAYPNGVGKTKKEAKRNAAKHALIGMMETTEQKDASVSCPPSPAPSPAPPVRAVISQPKYVSWLNEHSQKNKLSLKALEGARVGPNNTSQCCRYVVGEKEYPEGFGNTKKEAKEEAAMQVYLELCGGSQTTGTVDENCNGTTGKHKEELNGKVVVLSEKVEHMNMSPAQNVPEQYSFITTEETNFIGILNHYCQKTKRFLDFKLVEKSGPSHNPQFVYKVLIDKREYPDGLGKTAKEAKQQAAQLAWSALQEQSDWNSQVSCRSTVSEEGGLSSLTPSSTWESQDATPSSLSIAGSTSESIIFSDSVNVSSPKDESPVNVKPKIRLAANFQMSPVKTKQEGPNLKGNDLGTLSSGRTSNQPVISRFSSEFDSIENIGKGGFGHVYKARRKLEQKYFAVKIVRSKGKAKREVGALADLQHPNIVRYYTAWLEDTAYRCDTASESDTTSDSGSSSSSEFLYIQMELCDKRTLKVWIDERNAHRKPKRREESLSITQQIVNGVEYIHSKKLLHRDLKPANIMFGMSDGEGKGEVKIGDFGLVTAEDNDNDENLLERTKKTGTVSYMAPEQRNQTSYDRKVDIFALGLIYFEPLWDLSGMEKAKVWNDVRSQRFPQQFNSQFTLENKVIESLLCANPEERPDARQLKTKLNECSRVLTRVHNIHQDNRTI,negative +UCAAUCGGCGCUUUACUCUUGCGCUCACCGUGCCC,MQRTKEAVKASDGNLLGDPGRIPLSKRESIKWQRPRFTRQALMRCCLIKWILSSAAPQGSDSSDSELELSTVRHQPEGLDQLQAQTKFTKKELQSLYRGFKNECPTGLVDEDTFKLIYSQFFPQGDATTYAHFLFNAFDADGNGAIHFEDFVVGLSILLRGTVHEKLKWAFNLYDINKDGCITKEEMLAIMKSIYDMMGRHTYPILREDAPLEHVERFFQKMDRNQDGVVTIDEFLETCQKDENIMNSMQLFENVI,negative +CGCCGTATTAAGATTGGGAGACCTGGTAGA,MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC,negative +GGGAGAAGGGAAGTAACAGGCUAGAAGUUUAGACCAAGGGGCGGGAUGAGTGAGAAGAGGTGACGGTACCAG,MHRPQRQQWIANGCAPKWRAMMRLAAAVAVLVVVTTLATAATAAGAKNEHQQQQQQQAWMESFPPMSADFPAGPALSDAEAAFLQVPEAERCRAHLKYLTSLPHVAGTPGDYETAEYVLNQFKSFGLDAVIQNETVLLTAPVEAASAKLYSADGTTLVYAAALSEDLLDPTADTPYRNHSFLGYSPTGSAAGPLVYVNYGSTEDFEYLVAQGVNLTGAIAIARYGSIFRGLKALNAQTHGMAGLIIYSDPSDDGYAQGQLYPNGPWRPESGIQRGSVVFNSLCGGDPGRGVDKCGIPLEDLIPSIPVLPMGYGDAVQFLSHIVGAPAPASWQGALPFQYNIGPGAFARIATNNTQYTTDIWNVVAYINGTDPVEGEDYVILGNHRDAWVYGAVDPNSGTAALLEIARAYGVLLQGGWQPKRGLVLTSWDGEEYGLLGSTAFGERFADDLILHAVAYLNIDTAVMGPQLWVTLVPSLLTHFRQTAALVKDPVTGNPLSVEWDGSYDIMGSGSDYTVFLDALGVASGDLLFGGAYGVYHSVFDSFNWMETQGDPTFQYHEACAQIFGLVGLRLADARILPFNYTEYAYAISTFYLPQVQQLATDAKLPVDFTALTNAAQQFASGASKIMSRVEQAYNNPNYNVVDLNSRLFLAERQFTDPNGIINRKWFKHTVFAPDRENGYDASSFPGIVDMIRTGNATLAQQAITSAATALSNVGTFLSY,negative +UUUGGUUAUCAUGUUUAUGCGUACGGGCGCCCAU,VFTDNSSPPAVPQSFQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGFGAYMSKAHGVDPNIRTGVRTITTGSPITYSTYGKFLADGGCSGGAYDIIICDECHSTDATSILGIGTVLDQAETAGARLVVLATATPPGSVTVSHPNIEEVALSTTGEIPFYGKAIPLEVIKGGRHLIFCHSKKKCDELAAKLVALGINAVAYYRGLDVSVIPTSGDVVVVSTDALMTGFTGDFDSVIDCNTCVTQTVDFSLDPTFTIETTTLPQDAVSRTQRRGRTGRGKPGIYRFVAPGERPSGMFDSSVLCECYDAGCAWYELTPAETTVRLRAYMNTPGLPVCQDHLEFWEGVFTGLTHIDAHFLSQTKQSGENFPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPTLHGPTPLLYRLGAVQNEVT,negative +GGAGACCGTACCATCTGTTCGTGGAAGCGCTTTGCTCGTCCATTAGCCTTGTGCTCGTGC,MKKRKVLIPLMALSTILVSSTGNLEVIQAEVKQENRLLNESESSSQGLLGYYFSDLNFQAPMVVTSSTTGDLSIPSSELENIPSENQYFQSAIWSGFIKVKKSDEYTFATSADNHVTMWVDDQEVINKASNSNKIRLEKGRLYQIKIQYQRENPTEKGLDFKLYWTDSQNKKEVISSDNLQLPELKQKSSNSRKKRSTSAGPTVPDRDNDGIPDSLEVEGYTVDVKNKRTFLSPWISNIHEKKGLTKYKSSPEKWSTASDPYSDFEKVTGRIDKNVSPEARHPLVAAYPIVHVDMENIILSKNEDQSTQNTDSQTRTISKNTSTSRTHTSEVHGNAEVHASFFDIGGSVSAGFSNSNSSTVAIDHSLSLAGERTWAETMGLNTADTARLNANIRYVNTGTAPIYNVLPTTSLVLGKNQTLATIKAKENQLSQILAPNNYYPSKNLAPIALNAQDDFSSTPITMNYNQFLELEKTKQLRLDTDQVYGNIATYNFENGRVRVDTGSNWSEVLPQIQETTARIIFNGKDLNLVERRIAAVNPSDPLETTKPDMTLKEALKIAFGFNEPNGNLQYQGKDITEFDFNFDQQTSQNIKNQLAELNATNIYTVLDKIKLNAKMNILIRDKRFHYDRNNIAVGADESVVKEAHREVINSSTEGLLLNIDKDIRKILSGYIVEIEDTEGLKEVINDRYDMLNISSLRQDGKTFIDFKKYNDKLPLYISNPNYKVNVYAVTKENTIINPSENGDTSTNGIKKILIFSKKGYEIG,negative +AUCUCCCACACUUCAUCGGUUCACCCUACUCCCUUGCAU,MTRCTADNSLTNPAYRRRTMATGEMKEFLGIKGTEPTDFGINSDAQDLPSPSRQASTRRMSIGESIDGKINDWEEPRLDIEGFVVDYFTHRIRQNGMEWFGAPGLPCGVQPEHEMMRVMGTIFEKKHAENFETFCEQLLAVPRISFSLYQDVVRTVGNAQTDQCPMSYGRLIGLISFGGFVAAKMMESVELQGQVRNLFVYTSLFIKTRIRNNWKEHNRSWDDFMTLGKQMKEDYERAEAEKVGRRKQNRRWSMIGAGVTAGAIGIVGVVVCGRMMFSLK,negative +AGAGAGAAAGCCAACCATAGCAAATGATACGGAGATTTTG,MLSWGYFLFLLPTLPGAQSQVQLVESGGDVRKPGDSLRLSCKGSGFTFSNYWLGWVRQAPGKALNGSLPLTPLAAAPTYIPGVSGRFTISRDNARALLHLDMSDLRPEDTGRYHCER,negative +CAGCTCAGAAGCTTGATCCTGTGCGGGCGGCAAGGCCCTGACAGAGATACTGGCTCGGGACTCGAAGTCGTGCATCTGCA,MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINYDEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQAVAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQGIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADMDFSALLSQISS,negative +ACUCACCAGUCACCAUCAGCUCAUGCGCCCCUCCCCCGAC,MEGMLKGEGPGPLPPLLQQYVELRDQYPDYLLLFQVGDFYECFGEDAERLARALGLVLTHKTSKDFTTPMAGIPLRAFEAYAERLLKMGFRLAVADQVEPAEEAEGLVRREVTQLLTPGTLLQESLLPREANYLAAIATGDGWGLAFLDVSTGEFKGTVLKSKSALYDELFRHRPAEVLLAPELLENGAFLDEFRKRFPVMLSEAPFEPEGEGPLALRRARGALLAYAQRTQGGALSLQPFRFYDPGAFMRLPEATLRALEVFEPLRGQDTLFSVLDETRTAPGRRLLQSWLRHPLLDRGPLEARLDRVEGFVREGALREGVRRLLYRLADLERLATRLELGRASPKDLGALRRSLQILPELRALLGEEVGLPDLSPLKEELEAALVEDPPLKVSEGGLIREGYDPDLDALRAAHREGVAYFLELEERERERTGIPTLKVGYNAVFGYYLEVTRPYYERVPKEYRPVQTLKDRQRYTLPEMKEKEREVYRLEALIRRREEEVFLEVRERAKRQAEALREAARILAELDVYAALAEVAVRYGYVRPRFGDRLQIRAGRHPVVERRTEFVPNDLEMAHELVLITGPNMAGKSTFLRQTALIALLAQVGSFVPAEEAHLPLFDGIYTRIGASDDLAGGKSTFMVEMEEVALILKEATENSLVLLDEVGRGTSSLDGVAIATAVAEALHERRAYTLFATHYFELTALGLPRLKNLHVAAREEAGGLVFYHQVLPGPASKSYGVEVAAMAGLPKEVVARARALLQAMAARREGALDAVLERLLALDPDRLTPLEALRLLQELKALALGAPLDTMKG,negative +AGCUUACAAAACCUGUAGUUUUAUGCUUCACAUAUCGCACAGGACGCGUUAAGCU,MSDLANSEKYYDEDPYGFEDESAPITAEDSWAVISAFFREKGLVSQQLDSFNQFVDYTLQDIICEDSTLILEQLAQHTTESDNISRKYEISFGKIYVTKPMVNESDGVTHALYPQEARLRNLTYSSGLFVDVKKRTYEAIDVPGRELKYELIAEESEDDSESGKVFIGRLPIMLRSKNCYLSEATESDLYKLKECPFDMGGYFIINGSEKVLIAQERSAGNIVQVFKKAAPSPISHVAEIRSALEKGSRFISTLQVKLYGREGSSARTIKATLPYIKQDIPIVIIFRALGIIPDGEILEHICYDVNDWQMLEMLKPCVEDGFVIQDRETALDFIGRRGTALGIKKEKRIQYAKDILQKEFLPHITQLEGFESRKAFFLGYMINRLLLCALDRKDQDDRDHFGKKRLDLAGPLLAQLFKTLFKKLTKDIFRYMQRTVEEAHDFNMKLAINAKTITSGLKYALATGNWGEQKKAMSSRAGVSQVLNRYTYSSTLSHLRRTNTPIGRDGKLAKPRQLHNTHWGLVCPAETPEGQACGLVKNLSLMSCISVGTDPMPIITFLSEWGMEPLEDYVPHQSPDATRVFVNGVWHGVHRNPARLMETLRTLRRKGDINPEVSMIRDIREKELKIFTDAGRVYRPLFIVEDDESLGHKELKVRKGHIAKLMATEYQDIEGGFEDVEEYTWSSLLNEGLVEYIDAEEEESILIAMQPEDLEPAEANEENDLDVDPAKRIRVSHHATTFTHCEIHPSMILGVAASIIPFPDHNQSPRNTYQSAMGKQAMGVFLTNYNVRMDTMANILYYPQKPLGTTRAMEYLKFRELPAGQNAIVAIACYSGYNQEDSMIMNQSSIDRGLFRSLFFRSYMDQEKKYGMSITETFEKPQRTNTLRMKHGTYDKLDDDGLIAPGVRVSGEDVIIGKTTPISPDEEELGQRTAYHSKRDASTPLRSTENGIVDQVLVTTNQDGLKFVKVRVRTTKIPQIGDKFASRHGQKGTIGITYRREDMPFTAEGIVPDLIINPHAIPSRMTVAHLIECLLSKVAALSGNEGDASPFTDITVEGISKLLREHGYQSRGFEVMYNGHTGKKLMAQIFFGPTYYQRLRHMVDDKIHARARGPMQVLTRQPVEGRSRDGGLRFGEMERDCMIAHGAASFLKERLMEASDAFRVHICGICGLMTVIAKLNHNQFECKGCDNKIDIYQIHIPYAAKLLFQELMAMNITPRLYTDRSRDF,negative +AATACCCCCCCTTCGGTGCAAAGCACCGAAGGGGGGG,MAKGEFIRTKPHVNVGTIGHVDHGKTTLTAALTYVAAAENPNVEVKDYGDIDKAPEERARGITINTAHVEYETAKRHYSHVDCPGHADYIKNMITGAAQMDGAILVVSAADGPMPQTREHILLARQVGVPYIVVFMNKVDMVDDPELLDLVEMEVRDLLNQYEFPGDEVPVIRGSALLALEEMHKNPKTKRGENEWVDKIWELLDAIDEYIPTPVRDVDKPFLMPVEDVFTITGRGTVATGRIERGKVKVGDEVEIVGLAPETRKTVVTGVEMHRKTLQEGIAGDNVGLLLRGVSREEVERGQVLAKPGSITPHTKFEASVYILKKEEGGRHTGFFTGYRPQFYFRTTDVTGVVRLPQGVEMVMPGDNVTFTVELIKPVALEEGLRFAIREGGRTVGAGVVTKILE,negative +UUAGCACAAACAACCCCAGAAGUGCAACGC,MKRASAGGSRLLAWVLWLQAWQVAAPCPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDNPWVCDCRARPLWAWLQKFRGSSSEVPCSLPQRLAGRDLKRLAANDLQGCAVATGPYHPIWTGRATDEEPLGLPKCCQPDAADKASVLEPGRPASAGNALKGRVPPGDSPPGNGSGPRHINDSPFGTLPGSAEPPLTAVRPEGSEPPGFPTSGPRRRPGCSRKNRTRSHCRLGQAGSGGGGTGDSEGSGALPSLTCSLTPLGLALVLWTVLGPC,negative +CTTCTGCCCGCCTCCTTCCAGAGTAGCCAAGCGGAGAGTATTTTTGACTGCTTCCCCCGGAGACGAGATAGGCGGACACT,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +AGCATATAGTATAAAATTATCATATTGGTGTACGTGTACGGGGTACTTTT,MKPGGNTIVIWMYAVATWLCFGSTSGWSFTLEDNNIFPKQYPIINFTTAGATVQSYTNFIRAVRGRLTTGADVRHEIPVLPNRVGLPINQRFILVELSNHAELSVTLALDVTNAYVVGYRAGNSAYFFHPDNQEDAEAITHLFTDVQNRYTFAFGGNYDRLEQLAGNLRENIELGNGPLEEAISALYYYSTGGTQLPTLARSFIICIQMISEAARFQYIEGEMRTRIRYNRRSAPDPSVITLENSWGRLSTAIQESNQGAFASPIQLQRRNGSKFSVYDVSILIPIIALMVYRCAPPPSSQFSLLIRPVVPNFNADVCMDPEPIVRIVGRNGLCVDVRDGRFHNGNAIQLWPCKSNTDANQLWTLKRDNTIRSNGKCLTTYGYSPGVYVMIYDCNTAATDATRWQIWDNGTIINPRSSLVLAATSGNSGTTLTVQTNIYAVSQGWLPTNNTQPFVTTIVGLYGLCLQANSGQVWIEDCSSEKAEQQWALYADGSIRPQQNRDNCLTSDSNIRETVVKILSCGPASSGQRWMFKNDGTILNLYSGLVLDVRASDPSLKQIILYPLHGDPNQIWLPLF,negative +AGGTTTAGTGAATATCTTCGATGATCCGAGGCAGGCTAGATTCCGAAACATCGTTGAGCG,MIPPPRRSASSTPKDYRSSRDLQPWRGVSSGDAAETSQQSRHRRDAIADGGGRLKGAAQSSPSSGTRRSGPYAQGRAMPKNENIPKPGKQRLGPRKKKLSTLKKKILLDRLERWRDKQHEGALSTPSATASSEEAKCNNPFPLCPPGELSPPPSPPATICPAVVDKSTSYGQVGGANGERSVWAITIYNLVDQEDVEDDDDHAEIERDLWDMSSAFGVVRSVQVPRGTAVQVSDAEVSAAAAAGEPAAVAAKVAFATNAEAECARDGLNGRIVGGKPLLVRIHRCDGHFCGGVCPGDPDGSGLWRVAIENLIDEEDDLDDEDEYAEISANVSAMMGCYGKLVDVQVRRSSPSKGEVQEDVATRAATTAGATQAVVVTFGSLAEAEACVQGIKGCRVGGKELDAHVVLDSERVLPSNPAFKCDQEHAHSSDVAAAVAGQGDSMMKQEAGTEPSPCVDQDTAAAVASSTEWRVVIRGLIDEDDLQDDDDDYAEVCSDVTALVSSYGAVVGLDIPRGRETGSCCYGAEPGEAVVVFRSLQEAEACARGLSGRKVAGNILDAQVLTQPAPSQQGPLQGGASGTGPPVANRERKPAKECPLPQHQASSHQSCGKVPELDGSGPGMLRGFGNRVEDCCGRPKIACTDSDEPQAIAAAAPPGQSIEGPKTTALAKAGKRIQTKYQEAAALPKPPGVRGGLPNAYVNQPPDKEVNDLVFEMLQLLFKFQERARLSDPSKAKTRRRLVIGLREVLRGVKAKKVRLLIVAPNVDAVGGEGGLDDKVVEIIDKAREAEYPVVFALSKRKIGKALGKTIKVSAVGVYSFDGANEQQKQLKRRMETISSLPSPSPRQSDPPTDDALASPPSSSACGDSQDPAGKGSRV,negative +CGUAUUCAUCAGGUAGCGUAGAUCCGUGUGGCGGGCUGUUCCAUUUUA,MASNFTQFVLVDNGGTGDVTVAPSNFANGVAEWISSNSRSQAYKVTCSVRQSSAQNRKYTIKVEVPKVATQTVGGVELPVAAWRSYLNMELTIPIFATNSDCELIVKAMQGLLKDGNPIPSAIAANSGIY,negative +GGGAGAAGGGAAGTAACAGGUGGGCGCGUGAUUAUGUUUGUACGAAGACUGTGAGAAGAGGTGACGGTACCAG,MGVLLTQRTLLSLVLALLFPSMASMAAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQGLDVPKLREHCRERPGAFPSEETLRGLGRRGFLQTLNATLGCVLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILGLRNNIYCMAQLLDNSDTAEPTKAGRGASQPPTPTPASDAFQRKLEGCRFLHGYHRFMHSVGRVFSKWGESPNRSRRHSPHQALRKGVRRTRPSRKGKRLMTRGQLPR,negative +AGCGACCU,MGVHECPAWLWLLLSLLSLPLGLPVLGAPPRLICDSRVLERYLLEAKEAENITTGCAEHCSLNENITVPDTKVNFYAWKRMEVGQQAVEVWQGLALLSEAVLRGQALLVNSSQPWEPLQLHVDKAVSGLRSLTTLLRALGAQKEAISPPDAASAAPLRTITADTFRKLFRVYSNFLRGKLKLYTGEACRTGDR,negative +CTTCTGCCCGCCTCCTTCCCTAGTGCAGGGGTTCACTCAGGACCTTACGAGCTTTTTCGGAGACGAGATAGGCGGACACT,PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGKISKIGPENPYNTPVFAIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDESFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPXRXKNPEMVIYQYMDDLYVGSDLEIGQHRAKIEELRSHLLSWGFTTPDKKHQKEPPFLWMGYELHPDSWTVQPIELPEKDSWTVNE,negative +CCCAAUUCCGACCUGCGUCUACGUAACCUGCCAUCG,MHGDTPTLHEYMLDLQPETTDLYCYEQLNDSSEEEDEIDGPAGQAEPDRAHYNIVTFCCKCDSTLRLCVQSTHVDIRTLEDLLMGTLGIVCPICSQKP,negative +GGCAGGAAGACAAACACGATGGGGGGGTATGATTTGATGTGGTTGTTGCATGATCGTGGTCTGTGGTGCTCT,MPSNQEARLFLAVLVLAQVLPILVDSAAEKGFKQAFWQPLCQVSEELDDQPKGALFTLQAAASKIQKMRDAALRASIYAEINHGTNRAKAAVIVANHYAMKADSGLEALKQTLSSQEVTATATASYLKGRIDEYLNLLLQTKESGTSGCMMDTSGTNTVTKAGGTIGGVPCKLQLSPIQPKRPAATYLGKAGYVGLTRQADAANNFHDNDAECRLASGHNTNGLGKSGQLSAAVTMAAGYVTVANSQTAVTVQALDALQEASGAAHQPWIDAWKAKKALTGAETAEFRNETAGIAGKTGVTKLVEEALLKKKDSEASEIQTELKKYFSGHENEQWTAIEKLISEQPVAQNLVGDNQPTKLGELEGNAKLTTILAYYRMETAGKFEVLTQKHKPAESQQQAAETEGSCNKKDQNECKSPCKWHNDAENKKCTLDKEEAKKVADETAKDGKTGNTNTTGSSNSFVISKTPLWLAVLLF,negative +CGGTCGCTCCGTGTGGCTTGGGTTGGGTGTGGCAGTGAC,MQLPLALCLVCLLVHTAFRVVEGQGWQAFKNDATEIIPELGEYPEPPPELENNKTMNRAENGGRPPHHPFETKDVSEYSCRELHFTRYVTDGPCRSAKPVTELVCSGQCGPARLLPNAIGRGKWWRPSGPDFRCIPDRYRAQRVQLLCPGGEAPRARKVRLVASCKCKRLTRFHNQSELKDFGTEAARPQKGRKPRPRARSAKANQAELENAY,negative +AAUAACUC,QELLCAASLISDRWVLTAAHCLLYPPWDKNFTVNDILVRIGKYARSRYERNMEKISTLEKIIIHPGYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDKQIVTSLLQAGHKGRVTGWGNLKEMWTVNMNEVQPSVLQMVNLPLVERPICKASTGIRVTDNMFCAGYKPEEGKRGDACEGDSGGPFVMKNPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIRKMVDRFG,negative +CATCTCGGTCGTGAACTTTACATGCATGAGTATTTTGGTG,MGLLGILCFLIFLGKTWGQEQTYVISAPKIFRVGASENIVIQVYGYTEAFDATISIKSYPDKKFSYSSGHVHLSSENKFQNSAILTIQPKQLPGGQNPVSYVYLEVVSKHFSKSKRMPITYDNGFLFIHTDKPVYTPDQSVKVRVYSLNDDLKPAKRETVLTFIDPEGSEVDMVEEIDHIGIISFPDFKIPSNPRYGMWTIKAKYKEDFSTTGTAYFEVKEYVLPHFSVSIEPEYNFIGYKNFKNFEITIKARYFYNKVVTEADVYITFGIREDLKDDQKEMMQTAMQNTMLINGIAQVTFDSETAVKELSYYSLEDLNNKYLYIAVTVIESTGGFSEEAEIPGIKYVLSPYKLNLVATPLFLKPGIPYPIKVQVKDSLDQLVGGVPVTLNAQTIDVNQETSDLDPSKSVTRVDDGVASFVLNLPSGVTVLEFNVKTDAPDLPEENQAREGYRAIAYSSLSQSYLYIDWTDNHKALLVGEHLNIIVTPKSPYIDKITHYNYLILSKGKIIHFGTREKFSDASYQSINIPVTQNMVPSSRLLVYYIVTGEQTAELVSDSVWLNIEEKCGNQLQVHLSPDADAYSPGQTVSLNMATGMDSWVALAAVDSAVYGVQRGAKKPLERVFQFLEKSDLGCGAGGGLNNANVFHLAGLTFLTNANADDSQENDEPCKEILRPRRTLQKKIEEIAAKYKHSVVKKCCYDGACVNNDETCEQRAARISLGPRCIKAFTECCVVASQLRANISHKDMQLGRLHMKTLLPVSKPEIRSYFPESWLWEVHLVPRRKQLQFALPDSLTTWEIQGVGISNTGICVADTVKAKVFKDVFLEMNIPYSVVRGEQIQLKGTVYNYRTSGMQFCVKMSAVEGICTSESPVIDHQGTKSSKCVRQKVEGSSSHLVTFTVLPLEIGLHNINFSLETWFGKEILVKTLRVVPEGVKRESYSGVTLDPRGIYGTISRRKEFPYRIPLDLVPKTEIKRILSVKGLLVGEILSAVLSQEGINILTHLPKGSAEAELMSVVPVFYVFHYLETGNHWNIFHSDPLIEKQKLKKKLKEGMLSIMSYRNADYSYSVWKGGSASTWLTAFALRVLGQVNKYVEQNQNSICNSLLWLVENYQLDNGSFKENSQYQPIKLQGTLPVEARENSLYLTAFTVIGIRKAFDICPLVKIDTALIKADNFLLENTLPAQSTFTLAISAYALSLGDKTHPQFRSIVSALKREALVKGNPPIYRFWKDNLQHKDSSVPNTGTARMVETTAYALLTSLNLKDINYVNPVIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVKQLRLSMDIDVSYKHKGALHNYKMTDKNFLGRPVEVLLNDDLIVSTGFGSGLATVHVTTVVHKTSTSEEVCSFYLKIDTQDIEASHYRGYGNSDYKRIVACASYKPSREESSSGSSHAVMDISLPTGISANEEDLKALVEGVDQLFTDYQIKDGHVILQLNSIPSSDFLCVRFRIFELFEVGFLSPATFTVYEYHRPDKQCTMFYSTSNIKIQKVCEGAACKCVEADCGQMQEELDLTISAETRKQTACKPEIAYAYKVSITSITVENVFVKYKATLLDIYKTGEAVAEKDSEITFIKKVTCTNAELVKGRQYLIMGKEALQIKYNFSFRYIYPLDSLTWIEYWPRDTTCSSCQAFLANLDEFAEDIFLNGC,negative +CCGTAGGTTCGGGGCGGAGTGGTCCGGAAGGTGGCGTGG,MAGRSGDSDEELLKAVRLIKFLYQSNPPPNPEGTRQARRNRRRRWRERQRQIHSISERILSTYLGRSAEPVPLQLPPLERLTLDCNEDCGTSGTQGVGSPQILVESPTILESGAKE,negative +CGCCAGUGUGAAAGAUCCGAAGUUUAUGCCGGCACGCGCUGGCG,MKTLLLLLLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAKEPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHSRFQPSQSSTYSQPGQSFSIQYGTGSLSGIIGADQVSAFATQVEGLTVVGQQFGESVTEPGQTFVDAEFDGILGLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSHFSGSLNWVPVTKQAYWQIALDNIQVGGTVMFCSEGCQAIVDTGTSLITGPSDKIKQLQNAIGAAPVDGEYAVECANLNVMPDVTFTINGVPYTLSPTAYTLLDFVDGMQFCSSGFQGLDIHPPAGPLWILGDVFIRQFYSVFDRGNNRVGLAPAVP,negative +AAGACGGCCGGCGCCAUAGCCGAGAUCCGAGGUUGUAC,VENLMVQELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFSHFRLFDENNDAAILILLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVN,negative +CACGGTAGTGCTACCAGATGGTTATGTTACTTCAATTCTG,MAIPKELLVLLLGIAILSKVAECAAFGSRRGLVETVFDVTRFGARPNTPADSTRGLMMAWRSACQSPGPAKVVIPPGTYTTGETIFQGPCTSPRPITIEIQGTLLSNTDMSLYTRAAWISIEHVDGIVITGGGTLNGQGKSSWQFADKSGSTPPLPSSLVFQTVRSSSIKNLNFVDAKGVHLKITDSSDISVSNIKITAPGDSPNTDGLHISDTINVNVTDSTIGTGDDCISIGDGNSNVYISNINCGPGHGISIGSLGKRLDETDVKGVTVRNCTFRGTTNGARIKTYMGSPSLQVSGVVYEDIILDNVKNPIVIDQHYHSKNRNEPSRVKLVDIHFRNIRGTTTSKIPVLLNCSEALPCEGVELVDIDLAPVGSIGPLLPATCQNAKTILNGKNNPPAC,negative +GGTTGGTTTATTTTATTACTAGTGGCCAGG,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +GGAATAGAGACAAAGCCACTCATATGAGT,MSSSQKKAGGKAGKPTKRSQNYAALRKAQLPKPPALKVPVVKPTNTILPQTGCVWQSLGTPLSLSSFNGLGARFLYSFLKDFVGPRILEEDLIYRMVFSITPSHAGTFCLTDDVTTEDGRAVAHGNPMQEFPHGAFHANEKFGFELVFTAPTHAGMQNQNFKHSYAVALCLDFDAQPEGSKNPSFRFNEVWVERKAFPRAGPLRSLITVGLFDEADDLDRH,negative +AGGGAATCTTGCCTAGGGAGGGAGTAGCGAAAGGGCTCA,MEGMLKGEGPGPLPPLLQQYVELRDQYPDYLLLFQVGDFYECFGEDAERLARALGLVLTHKTSKDFTTPMAGIPLRAFEAYAERLLKMGFRLAVADQVEPAEEAEGLVRREVTQLLTPGTLLQESLLPREANYLAAIATGDGWGLAFLDVSTGEFKGTVLKSKSALYDELFRHRPAEVLLAPELLENGAFLDEFRKRFPVMLSEAPFEPEGEGPLALRRARGALLAYAQRTQGGALSLQPFRFYDPGAFMRLPEATLRALEVFEPLRGQDTLFSVLDETRTAPGRRLLQSWLRHPLLDRGPLEARLDRVEGFVREGALREGVRRLLYRLADLERLATRLELGRASPKDLGALRRSLQILPELRALLGEEVGLPDLSPLKEELEAALVEDPPLKVSEGGLIREGYDPDLDALRAAHREGVAYFLELEERERERTGIPTLKVGYNAVFGYYLEVTRPYYERVPKEYRPVQTLKDRQRYTLPEMKEKEREVYRLEALIRRREEEVFLEVRERAKRQAEALREAARILAELDVYAALAEVAVRYGYVRPRFGDRLQIRAGRHPVVERRTEFVPNDLEMAHELVLITGPNMAGKSTFLRQTALIALLAQVGSFVPAEEAHLPLFDGIYTRIGASDDLAGGKSTFMVEMEEVALILKEATENSLVLLDEVGRGTSSLDGVAIATAVAEALHERRAYTLFATHYFELTALGLPRLKNLHVAAREEAGGLVFYHQVLPGPASKSYGVEVAAMAGLPKEVVARARALLQAMAARREGALDAVLERLLALDPDRLTPLEALRLLQELKALALGAPLDTMKG,negative +TCAAAAGGGGTGATTGCTTGCACAATGACAGGGTAGGACA,MLDLFADAEPWQEPLAAGAVILRRFAFNAAEQLIRDINDVASQSPFRQMVTPGGYTMSVAMTNCGHLGWTTHRQGYLYSPIDPQTNKPWPAMPQSFHNLCQRAATAAGYPDFQPDACLINRYAPGAKLSLHQDKDEPDLRAPIVSVSLGLPAIFQFGGLKRNDPLKRLLLEHGDVVVWGGESRLFYHGIQPLKAGFHPLTIDCRYNLTFRQAGKKE,negative +AUCAGCCAUGUUUACGUCACUCCUUGUCAAUCCUCAUCGG,MEGMLKGEGPGPLPPLLQQYVELRDQYPDYLLLFQVGDFYECFGEDAERLARALGLVLTHKTSKDFTTPMAGIPLRAFEAYAERLLKMGFRLAVADQVEPAEEAEGLVRREVTQLLTPGTLLQESLLPREANYLAAIATGDGWGLAFLDVSTGEFKGTVLKSKSALYDELFRHRPAEVLLAPELLENGAFLDEFRKRFPVMLSEAPFEPEGEGPLALRRARGALLAYAQRTQGGALSLQPFRFYDPGAFMRLPEATLRALEVFEPLRGQDTLFSVLDETRTAPGRRLLQSWLRHPLLDRGPLEARLDRVEGFVREGALREGVRRLLYRLADLERLATRLELGRASPKDLGALRRSLQILPELRALLGEEVGLPDLSPLKEELEAALVEDPPLKVSEGGLIREGYDPDLDALRAAHREGVAYFLELEERERERTGIPTLKVGYNAVFGYYLEVTRPYYERVPKEYRPVQTLKDRQRYTLPEMKEKEREVYRLEALIRRREEEVFLEVRERAKRQAEALREAARILAELDVYAALAEVAVRYGYVRPRFGDRLQIRAGRHPVVERRTEFVPNDLEMAHELVLITGPNMAGKSTFLRQTALIALLAQVGSFVPAEEAHLPLFDGIYTRIGASDDLAGGKSTFMVEMEEVALILKEATENSLVLLDEVGRGTSSLDGVAIATAVAEALHERRAYTLFATHYFELTALGLPRLKNLHVAAREEAGGLVFYHQVLPGPASKSYGVEVAAMAGLPKEVVARARALLQAMAARREGALDAVLERLLALDPDRLTPLEALRLLQELKALALGAPLDTMKG,negative +CAUACCAUCCCCAUUUUCGCAAUGAAAAG,MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPGPHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR,negative +GGGAGCTCAGAATAAACGCTCAACATGGATGGGAGGGTGGGGCTGGGTTGTAGAATATTCGACATGAGGCCCGGATC,MKPGGNTIVIWMYAVATWLCFGSTSGWSFTLEDNNIFPKQYPIINFTTAGATVQSYTNFIRAVRGRLTTGADVRHEIPVLPNRVGLPINQRFILVELSNHAELSVTLALDVTNAYVVGYRAGNSAYFFHPDNQEDAEAITHLFTDVQNRYTFAFGGNYDRLEQLAGNLRENIELGNGPLEEAISALYYYSTGGTQLPTLARSFIICIQMISEAARFQYIEGEMRTRIRYNRRSAPDPSVITLENSWGRLSTAIQESNQGAFASPIQLQRRNGSKFSVYDVSILIPIIALMVYRCAPPPSSQFSLLIRPVVPNFNADVCMDPEPIVRIVGRNGLCVDVRDGRFHNGNAIQLWPCKSNTDANQLWTLKRDNTIRSNGKCLTTYGYSPGVYVMIYDCNTAATDATRWQIWDNGTIINPRSSLVLAATSGNSGTTLTVQTNIYAVSQGWLPTNNTQPFVTTIVGLYGLCLQANSGQVWIEDCSSEKAEQQWALYADGSIRPQQNRDNCLTSDSNIRETVVKILSCGPASSGQRWMFKNDGTILNLYSGLVLDVRASDPSLKQIILYPLHGDPNQIWLPLF,negative +ACUCACCAGUCACCAUCAGCUCAUGCGCCCCUCCCCCGAC,MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC,negative +GGCAGCGAAAGCGGAACAAGUAUGUAACCAUGCCUCGGCAACUUUACAUGCGUAGCCAAACCCA,MARVRGPRLPGCLALAALFSLVHSQHVFLAHQQASSLLQRARRANKGFLEEVRKGNLERECLEEPCSREEAFEALESLSATDAFWAKYTACESARNPREKLNECLEGNCAEGVGMNYRGNVSVTRSGIECQLWRSRYPHKPEINSTTHPGADLRENFCRNPDGSITGPWCYTTSPTLRREECSVPVCGQDRVTVEVIPRSGGSTTSQSPLLETCVPDRGREYRGRLAVTTSGSRCLAWSSEQAKALSKDQDFNPAVPLAENFCRNPDGDEEGAWCYVADQPGDFEYCDLNYCEEPVDGDLGDRLGEDPDPDAAIEGRTSEDHFQPFFNEKTFGAGEADCGLRPLFEKKQVQDQTEKELFESYIEGRIVEGQDAEVGLSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTVDDLLVRIGKHSRTRYERKVEKISMLDKIYIHPRYNWKENLDRDIALLKLKRPIELSDYIHPVCLPDKQTAAKLLHAGFKGRVTGWGNRRETWTTSVAEVQPSVLQVVNLPLVERPVCKASTRIRITDNMFCAGYKPGEGKRGDACEGDSGGPFVMKSPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDRLGS,negative +CCAAGCAUCAGCUGG,QDRPIKFSTEGATSQSYKQFIEALRERLRGGLIHDIPVLPDPTTLQERNRYITVELSNSDTESIEVGIDVTNAYVVAYRAGTQSYFLRDAPSSASDYLFTGTDQHSLPFYGTYGDLERWAHQSRQQIPLGLQALTHGISFFRSGGNDNEEKARTLIVIIQMVAEAARFRYISNRVRVSIQTGTAFQPDAAMISLENNWDNLSRGVQESVQDTFPNQVTLTNIRNEPVIVDSLSHPTVAVLALMLFVCNPPNANQSPLLIRSIVEKSKICSSRYEPTVRIGGRDGMCVDVYDNGYHNGNRIIMWKCKDRLEENQLWTLKSDKTIRSNGKCLTTYGYAPGSYVMIYDCTSAVAEATYWEIWDNGTIINPKSALVLSAESSSMGGTLTVQTNEYLMRQGWRTGNNTSPFVTSISGYSDLCMQAQGSNVWMADCDSNKKEQQWALYTDGSIRSVQNTNNCLTSKDHKQGSTILLMGCSNGWASQRWVFKNDGSIYSLYDDMVMDVKGSDPSLKQIILWPYTGKPNQIWLTLF,negative +AATTTCTAATATAATTTCTAATAT,MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYTFLLPEMDNCRSSSSPYVSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQDNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVLVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF,negative +GCUAGGCAAUGAAACGGUUGGAGUAAUCCGGUGGCUUGCCAUGAUUUACGUGAGUGCUGAUCCGUGAUG,MPSKKNGRSGPQPHKRWVFTLNNPSEDERKKIRELPISLFDYFIVGEEGNEEGRTPHLQGFANFVKKQTFNKVKWYLGARCHIEKAKGTDQQNKEYCSKEGNLLMECGAPRSQGQRSDLSTAVSTLLESGSLVTVAEQHPVTFVRNFRGLAELLKVSGKMQKRDWKTNVHVIVGPPGCGKSKWAANFADPETTYWKPPRNKWWDGYHGEEVVVIDDFYGWLPWDDLLRLCDRYPLTVETKGGTVPFLARSILITSNQTPLEWYSSAAVPAVEALYRRITSLVFWKNATEQSTEEGGQFVTLSPPCPEFPYEINY,negative +CTAAGGATCGGATCCACGGCCTACCAGGTC,MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNLERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCPFGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGRVSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVFHKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVEGTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT,negative +GGGGGAGGACGCGTAGTGGGGGGCCCATGGTTGTGTGG,MGCRRTREGPSKAMIFPWKCQSTQRDLWNIFKLWGWTMLCCDFLAHHGTDCWTYHYSEKPMNWQRARRFCRDNYTDLVAIQNKAEIEYLEKTLPFSRSYYWIGIRKIGGIWTWVGTNKSLTEEAENWGDGEPNNKKNKEDCVEIYIKRNKDAGKWNDDACHKLKAALCYTASCQPWSCSGHGECVEIINNYTCNCDVGYYGPQCQFVIQCEPLEAPELGTMDCTHPLGNFSFSSQCAFSCSEGTNLTGIEETTCGPFGNWSSPEPTCQVIQCEPLSAPDLGIMNCSHPLASFSFTSACTFICSEGTELIGKKKTICESSGIWSNPSPICQKLDKSFSMIKEGDYNPLFIPVAVMVTAFSGLAFIIWLARRLKKGM,negative +CCGTAGGTTCGGGGTCGGAGTGGTCCGGAAGATGGCGTGG,MNQVTIQWDAVIALYILFSWCHGGITNINCSGHIWVEPATIFKMGMNISIYCQAAIKNCQPRKLHFYKNGIKERFQITRINKTTARLWYKNFLEPHASMYCTAECPKHFQETLICGKDISSGYPPDIPDEVTCVIYEYSGNMTCTWNAGKLTYIDTKYVVHVKSLETEEEQQYLTSSYINISTDSLQGGKKYLVWVQAANALGMEESKQLQIHLDDIVIPSAAVISRAETINATVPKTIIYWDSQTTIEKVSCEMRYKATTNQTWNVKEFDTNFTYVQQSEFYLEPNIKYVFQVRCQETGKRYWQPWSSLFFHKTPETVPQVTSKAFQHDTWNSGLTVASISTGHLTSDNRGDIGLLLGMIVFAVMLSILSLIGIFNRSFRTGIKRRILLLIPKWLYEDIPNMKNSNVVKMLQENSELMNNNSSEQVLYVDPMITEIKEIFIPEHKPTDYKKENTGPLETRDYPQNSLFDNTTVVYIPDLNTGYKPQISNFLPEGSHLSNNNEITSLTLKPPVDSLDSGNNPRLQKHPNFAFSVSSVNSLSNTIFLGELSLILNQGECSSPDIQNSVEEETTMLLENDSPSETIPEQTLLPDEFVSCLGIVNEELPSINTYFPQNILESHFNRISLLEK,negative +CCACAGUCACUGGG,QELLCAASLISDRWVLTAAHCLLYPPWDKNFTVNDILVRIGKYARSRYERNMEKISTLEKIIIHPGYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDKQIVTSLLQAGHKGRVTGWGNLKEMWTVNMNEVQPSVLQMVNLPLVERPICKASTGIRVTDNMFCAGYKPEEGKRGDACEGDSGGPFVMKNPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIRKMVDRFG,negative +GAAGTGAAAATGACAGAACACAACA,MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC,negative +TCTCATGCGCCGAGTGTGAGTTTACCTTCGT,PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGKISKIGPENPYNTPVFAIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDESFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPXRXKNPEMVIYQYMDDLYVGSDLEIGQHRAKIEELRSHLLSWGFTTPDKKHQKEPPFLWMGYELHPDSWTVQPIELPEKDSWTVNE,negative +GGGACACAAUGGACGUCCGUAGAAACGCGUUAAGGUGAAAGUUUGAGGGCUCCUCAUAACGGCCGACAUGAGAG,MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPGPHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR,negative +GGGAGAATTCCGACCAGAAGGCTTGCTGTTGTTTCCCTGTTGTTTTGTCTCTCAACTTTATTGTGGTAAAGATCACTGGGTTGATAAGGGCTAACTCTAATTTGACTACATGG,MEKVQYLTRSAIRRASTIEMPQQARQKLQNLFINFCLILICLLLICIIVMLL,negative +ATATTCGCGATTATT,RRIKRLEQEKLELSRKLQESTQTVQALQYSTVDGPLTASKDLEIKNLKEEIEKLRKQVTESSHLEQQLEEANAVRQELDDAFRQIKAYEKQIKTLQQEREDLNKELVQASERLKNQSKELKDAHCQRKLAMQEFMEINER,negative +GAGGACGAUGCGGACUAGCCUCAUCAGCUCAUGUGCCCCUC,MGVLLTQRTLLSLVLALLFPSMASMAAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQGLDVPKLREHCRERPGAFPSEETLRGLGRRGFLQTLNATLGCVLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILGLRNNIYCMAQLLDNSDTAEPTKAGRGASQPPTPTPASDAFQRKLEGCRFLHGYHRFMHSVGRVFSKWGESPNRSRRHSPHQALRKGVRRTRPSRKGKRLMTRGQLPR,negative +GCATCAAGACCCTGCGCATGGAGCCTTCTGCAACCACTCC,MVMGLGVLLLVFVLGLGLTPPTLAQDNSRYTHFLTQHYDAKPQGRDDRYCESIMRRRGLTSPCKDINTFIHGNKRSIKAICENKNGNPHRENLRISKSSFQVTTCKLHGGSPWPPCQYRATAGFRNVVVACENGLPVHLDQSIFRRP,negative +UUGUUACACACCCGCUUGAAAAAGCAAGUCUGACAA,MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC,negative +UGCGAUAAGGUGGUAGCGACAGUGAUAGAAGC,IMEIRTVAVGIVAIKGVESEYYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHSGGEMFVALNQKGLPVKGKKTKKEQKTAHFLPMAIT,negative +GGGAGAGGAGAGAACGUUCUACAGCGCCGGUGGGCGGGCAUUGGGUGGAUGCGCUGUCGAUCGAUCGAUCGAUG,WPLTEEKIKALVEICXEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEEFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDXIIYQYMDDLYVGSDLEIGQHRTKVEELRQHLLXWGFTTPDKKHQKEPPFLWMGYELHP,negative +CAUGUCUACAACAAUCUCGCCCGUUGAGUCUCGUCGAAUU,MDKLVVNYYEYKHPIINKDLAIGAHGGKKFPTLGAWYDVINEYEFQTRCPIILKNSHRNKHFTFACHLKNCPFKVLLSYAGNAASSETSSPSANNNTNPPGTPDHIHHHSNNMNNEDNDNNNGSNNKVSNDSKLDFVTDDLEYHLANTHPDDTNDKVESRSNEVNGNNDDDADANNIFKQQGVTIKNDTEDDSINKASIDRGLDDESGPTHGNDSGNHRHNEEDDVHTQMTKNYSDVVNDEDINVAIANAVANVDSQSNNKHDGKDDDATNNNDGQDNNTNNDHNNNSNINNNNVGSHGISSHSPSSIRDTSMNLDVFNSATDDIPGPFVVTKIEPYHSHPLEDNLSLGKFILTKIPKILQNDLKFDQILESSYNNSNHTVSKFKVSHYVEESGLLDILMQRYGLTAEDFEKRLLSQIARRITTYKARFVLKKKKMGEYNDLQPSSSSNNNNNNDGELSGTNLRSNSIDYAKHQEISSAGTSSNTTKNVNNNKNDSNDDNNGNNNNDASNLMESVLDKTSSHRYQPKKMPSVNKWSKPDQITHSDVSMVGLDESNDGGNENVHPTLAEVDAQEARETAQLAIDKINSYKRSIDDKNGDGHNNSSRNVVDENLINDMDSEDAHKSKRQHLSDITLEERNEDDKLPHEVAEQLRLLSSHLKEVENLHQNNDDDVDDVMVDVDVESQYNKNTTHHNNHHSQPHHDEEDVAGLIGKADDEEDLSDENIQPELRGQ,negative +GGTTGGTGTGGTTGG,MASNFTQFVLVDNGGTGDVTVAPSNFANGVAEWISSNSRSQAYKVTCSVRQSSAQNRKYTIKVEVPKVATQTVGGVELPVAAWRSYLNMELTIPIFATNSDCELIVKAMQGLLKDGNPIPSAIAANSGIY,negative +CAUGUCUACAACAAUCUCGCCCGUUGAGUCUCGUCGAAUU,IMEIRTVAVGIVAIKGVESEYYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHSGGEMFVALNQKGLPVKGKKTKKEQKTAHFLPMAIT,negative +GAAUCAAUACACAGUCCUGGGUGCUAACCAUGAACACCCAAGGCCUUAGUGGUGUGUGGUCCCUG,MGLLGILCFLIFLGKTWGQEQTYVISAPKIFRVGASENIVIQVYGYTEAFDATISIKSYPDKKFSYSSGHVHLSSENKFQNSAILTIQPKQLPGGQNPVSYVYLEVVSKHFSKSKRMPITYDNGFLFIHTDKPVYTPDQSVKVRVYSLNDDLKPAKRETVLTFIDPEGSEVDMVEEIDHIGIISFPDFKIPSNPRYGMWTIKAKYKEDFSTTGTAYFEVKEYVLPHFSVSIEPEYNFIGYKNFKNFEITIKARYFYNKVVTEADVYITFGIREDLKDDQKEMMQTAMQNTMLINGIAQVTFDSETAVKELSYYSLEDLNNKYLYIAVTVIESTGGFSEEAEIPGIKYVLSPYKLNLVATPLFLKPGIPYPIKVQVKDSLDQLVGGVPVTLNAQTIDVNQETSDLDPSKSVTRVDDGVASFVLNLPSGVTVLEFNVKTDAPDLPEENQAREGYRAIAYSSLSQSYLYIDWTDNHKALLVGEHLNIIVTPKSPYIDKITHYNYLILSKGKIIHFGTREKFSDASYQSINIPVTQNMVPSSRLLVYYIVTGEQTAELVSDSVWLNIEEKCGNQLQVHLSPDADAYSPGQTVSLNMATGMDSWVALAAVDSAVYGVQRGAKKPLERVFQFLEKSDLGCGAGGGLNNANVFHLAGLTFLTNANADDSQENDEPCKEILRPRRTLQKKIEEIAAKYKHSVVKKCCYDGACVNNDETCEQRAARISLGPRCIKAFTECCVVASQLRANISHKDMQLGRLHMKTLLPVSKPEIRSYFPESWLWEVHLVPRRKQLQFALPDSLTTWEIQGVGISNTGICVADTVKAKVFKDVFLEMNIPYSVVRGEQIQLKGTVYNYRTSGMQFCVKMSAVEGICTSESPVIDHQGTKSSKCVRQKVEGSSSHLVTFTVLPLEIGLHNINFSLETWFGKEILVKTLRVVPEGVKRESYSGVTLDPRGIYGTISRRKEFPYRIPLDLVPKTEIKRILSVKGLLVGEILSAVLSQEGINILTHLPKGSAEAELMSVVPVFYVFHYLETGNHWNIFHSDPLIEKQKLKKKLKEGMLSIMSYRNADYSYSVWKGGSASTWLTAFALRVLGQVNKYVEQNQNSICNSLLWLVENYQLDNGSFKENSQYQPIKLQGTLPVEARENSLYLTAFTVIGIRKAFDICPLVKIDTALIKADNFLLENTLPAQSTFTLAISAYALSLGDKTHPQFRSIVSALKREALVKGNPPIYRFWKDNLQHKDSSVPNTGTARMVETTAYALLTSLNLKDINYVNPVIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVKQLRLSMDIDVSYKHKGALHNYKMTDKNFLGRPVEVLLNDDLIVSTGFGSGLATVHVTTVVHKTSTSEEVCSFYLKIDTQDIEASHYRGYGNSDYKRIVACASYKPSREESSSGSSHAVMDISLPTGISANEEDLKALVEGVDQLFTDYQIKDGHVILQLNSIPSSDFLCVRFRIFELFEVGFLSPATFTVYEYHRPDKQCTMFYSTSNIKIQKVCEGAACKCVEADCGQMQEELDLTISAETRKQTACKPEIAYAYKVSITSITVENVFVKYKATLLDIYKTGEAVAEKDSEITFIKKVTCTNAELVKGRQYLIMGKEALQIKYNFSFRYIYPLDSLTWIEYWPRDTTCSSCQAFLANLDEFAEDIFLNGC,negative +GCGCAGGCGGGGTTTGACTTCGAGGCCG,MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQRGLKNVFDEAILAALEPPETQPKRKCCIF,negative +CAAGGCAGAAUGUAAUGCUGAAUAAGAGAGAAAAGUGUUGGUGAG,IMEIRTVAVGIVAIKGVESEYYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHSGGEMFVALNQKGLPVKGKKTKKEQKTAHFLPMAIT,negative +GCATGAATTCCCGAAGACGCAAACTGAAGAGGCACCGAAGGGGGGG,MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINYDEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQAVAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQGIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADMDFSALLSQISS,negative +GGAGACCGTACCATCTGTTCGTGGAAGCGCTTTGCTCGTCCATTAGCCTTGTGCTCGTGC,MEGMLKGEGPGPLPPLLQQYVELRDQYPDYLLLFQVGDFYECFGEDAERLARALGLVLTHKTSKDFTTPMAGIPLRAFEAYAERLLKMGFRLAVADQVEPAEEAEGLVRREVTQLLTPGTLLQESLLPREANYLAAIATGDGWGLAFLDVSTGEFKGTVLKSKSALYDELFRHRPAEVLLAPELLENGAFLDEFRKRFPVMLSEAPFEPEGEGPLALRRARGALLAYAQRTQGGALSLQPFRFYDPGAFMRLPEATLRALEVFEPLRGQDTLFSVLDETRTAPGRRLLQSWLRHPLLDRGPLEARLDRVEGFVREGALREGVRRLLYRLADLERLATRLELGRASPKDLGALRRSLQILPELRALLGEEVGLPDLSPLKEELEAALVEDPPLKVSEGGLIREGYDPDLDALRAAHREGVAYFLELEERERERTGIPTLKVGYNAVFGYYLEVTRPYYERVPKEYRPVQTLKDRQRYTLPEMKEKEREVYRLEALIRRREEEVFLEVRERAKRQAEALREAARILAELDVYAALAEVAVRYGYVRPRFGDRLQIRAGRHPVVERRTEFVPNDLEMAHELVLITGPNMAGKSTFLRQTALIALLAQVGSFVPAEEAHLPLFDGIYTRIGASDDLAGGKSTFMVEMEEVALILKEATENSLVLLDEVGRGTSSLDGVAIATAVAEALHERRAYTLFATHYFELTALGLPRLKNLHVAAREEAGGLVFYHQVLPGPASKSYGVEVAAMAGLPKEVVARARALLQAMAARREGALDAVLERLLALDPDRLTPLEALRLLQELKALALGAPLDTMKG,negative +ATCTTTGGCCCTCCACAATATCCCTCCATGGGGTACCAG,MSSTESPVPAAAAPAEAVPASTPAPAAEQPAVGNGEQRNNADAANNTSLYVGELDPSVTEAMLFEIFSMIGTVASIRVCRDAVTRRSLGYAYVNFLNAADGERAMEQLNYSLIRNRPCRIMWSQRDPALRRTGQGNIFIKNLDAGIDNKALHDTFAAFGNILSCKVATNETGSLGYGFVHYETAEAAEAAIKHVNGMLLNDKKVYVGHHIPRKERQAKIEETRANFTNVYAKNVDPEVTDDEFEKLFTKFGKITSCVLQRDEDGKSKGFGFVNFEDHNEAQKAVDELHDSDFKGQKLFVARAQKKSEREEELRRSYEAAKNEKLAKFQGVNLYLKNIPESYDDERLREEFAPFGAITSCKIMRAPSGVSRGFGFVCYSAPEEANKAVSEMNGKMLDNRPLYVALAQRKDVRRQQLEAQIMQRNQLRLQQQAAAQGMGYPGPGMYYPQPGAFPGQPGGMVPRPRYAPAGMMPQGMPMAPYGQPGQFPAGMMPQGYRPARPPRGAPNAAGGPAPPAGARPPTGVNGAPRPAGQPVPGQPMPRGPAARPAGRPEADQPGALTAAALAKASPEEQKQMLGEAIYPKVAASQPELAGKLTGMILELPVTELLHLLEESEALDAKVNEALEVLKEYQQNDSAGAEAEANAEAPKTEA,negative +CAAGGCAGAAUGUAAUGCUGAAUAAGAGAGAAAAGUGUUGGUGAGUGUAG,MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQRGLKNVFDEAILAALEPPETQPKRKCCIF,negative +GUAUUCUCGGUGGUUUAAUCAGAGUAGAGGAGGCUGACUCCUUUGGUUGGACGACGGUGGAGGUUCUUCUUG,MEKVQYLTRSAIRRASTIEMPQQARQKLQNLFINFCLILICLLLICIIVMLL,negative +GTCTCAATACGCACCCTGCATTCCCTTACTCGAGCCTAGC,WPLTEEKIKALVEICXEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEEFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDXIIYQYMDDLYVGSDLEIGQHRTKVEELRQHLLXWGFTTPDKKHQKEPPFLWMGYELHP,negative +AGCUUACAAAACCUGUAGUUUUAUGCUUCACAUAUCGCACAGGACGCGUUAAGCU,MAAKVASTSSEEAEGSLVTEGEMGEKALPVVYKRYICSFADCGAAYNKNWKLQAHLCKHTGEKPFPCKEEGCEKGFTSLHHLTRHSLTHTGEKNFTCDSDGCDLRFTTKANMKKHFNRFHNIKICVYVCHFENCGKAFKKHNQLKVHQFSHTQQLPYECPHEGCDKRFSLPSRLKRHEKVHAGYPCKKDDSCSFVGKTWTLYLKHVAECHQDLAVCDVCNRKFRHKDYLRDHQKTHEKERTVYLCPRDGCDRSYTTAFNLRSHIQSFHEEQRPFVCEHAGCGKCFAMKKSLERHSVVHDPEKRKLKEKCPRPKRSLASRLTGYIPPKSKEKNASVSGTEKTDSLVKNKPSGTETNGSLVLDKLTIQ,negative +GGGUUAACAAGAUACCGAGAGAGCUGCAGCAUAAGCCUGCAGAGUGGACCAGUACUACAAGCUUCUGGACUCGGU,ASFTCLAIWALASAGVVPLVLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAAFFFVPVIISTVCYVSIIRCLSSSAVANRSKK,negative +CTCCTCTGACTGTAACCACGCCGAAGAGCCTTTTTAGCGTACTGAAAAGGAGTTACTCTCGCATAGGTAGTCCAGAAGCC,MDKLVVNYYEYKHPIINKDLAIGAHGGKKFPTLGAWYDVINEYEFQTRCPIILKNSHRNKHFTFACHLKNCPFKVLLSYAGNAASSETSSPSANNNTNPPGTPDHIHHHSNNMNNEDNDNNNGSNNKVSNDSKLDFVTDDLEYHLANTHPDDTNDKVESRSNEVNGNNDDDADANNIFKQQGVTIKNDTEDDSINKASIDRGLDDESGPTHGNDSGNHRHNEEDDVHTQMTKNYSDVVNDEDINVAIANAVANVDSQSNNKHDGKDDDATNNNDGQDNNTNNDHNNNSNINNNNVGSHGISSHSPSSIRDTSMNLDVFNSATDDIPGPFVVTKIEPYHSHPLEDNLSLGKFILTKIPKILQNDLKFDQILESSYNNSNHTVSKFKVSHYVEESGLLDILMQRYGLTAEDFEKRLLSQIARRITTYKARFVLKKKKMGEYNDLQPSSSSNNNNNNDGELSGTNLRSNSIDYAKHQEISSAGTSSNTTKNVNNNKNDSNDDNNGNNNNDASNLMESVLDKTSSHRYQPKKMPSVNKWSKPDQITHSDVSMVGLDESNDGGNENVHPTLAEVDAQEARETAQLAIDKINSYKRSIDDKNGDGHNNSSRNVVDENLINDMDSEDAHKSKRQHLSDITLEERNEDDKLPHEVAEQLRLLSSHLKEVENLHQNNDDDVDDVMVDVDVESQYNKNTTHHNNHHSQPHHDEEDVAGLIGKADDEEDLSDENIQPELRGQ,negative +TCCGGCGCGCTGAGTGCCGGTTTATCCTCGT,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +CTCCTCTGACTGTAACCACGCCGAAGAGCCTTTTTAGCGTACTGAAAAGGAGTTACTCTCGCATAGGTAGTCCAGAAGCC,MSARGEEAAGEASGSQEQPEPALAEPKKRGPGRPRKPQQEPTGEPVPKRPRGRPKGSKNKGPSKAAQKKAETTGEKRPRGRPRKWPQQVVQEKPAQEEEEEEEEEEAEED,negative +TATTAGCAACAATATTAGCAACAA,QELLCAASLISDRWVLTAAHCLLYPPWDKNFTVNDILVRIGKYARSRYERNMEKISTLEKIIIHPGYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDKQIVTSLLQAGHKGRVTGWGNLKEMWTVNMNEVQPSVLQMVNLPLVERPICKASTGIRVTDNMFCAGYKPEEGKRGDACEGDSGGPFVMKNPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIRKMVDRFG,negative +GGGAGCUCAGCCUUCACUGCACUCCGGCUGGUGGACGCGGUACGAGCAAUUUGUACCGGAUGGAUGUUCGGGCAGCGGUGUGGCAGGGAUGAGCGGCACCACGGUCGGAUCCAC,MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA,negative +CAUAGGCUUACAACAGAGCGGGGGUUCUGAUGGUAGACGCCGGGACGCCC,MNRPHSCLSFCWMYFAASGIRAVETANGKYAQKLFSDLFEDYSSALRPVEDTDAVLNVTLQVTLSQIKDMDERNQILTAYLWIRQTWHDAYLTWDRDQYDRLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDSPAITKSSCVVDVTYFPFDSQQCNLTFGSWTYNGNQVDIFNALDSGDLSDFIEDVEWEVHGMPAVKNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGEKVSLGVTILLAMTVFQLMVAEIMPASENVPLIGKYYIATMALITASTALTIMVMNIHFCGAEARPVPHWAKVVILKYMSRILFVYDVGESCLSPRHSQEPEQVTKVYSKLPESNLKTSRNKDLSRKKEVRKLLKNDLGYQGGIPQNTDSYCARYEALTKNIEYIAKCLKDHKATNSKGSEWKKVAKVIDRFFMWIFFAMVFVMTVLIIARAD,negative +GGGAGGACGCGUCGCCGUAAUGGAUGUUUUGCUCCCUG,MKRASAGGSRLLAWVLWLQAWQVAAPCPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDNPWVCDCRARPLWAWLQKFRGSSSEVPCSLPQRLAGRDLKRLAANDLQGCAVATGPYHPIWTGRATDEEPLGLPKCCQPDAADKASVLEPGRPASAGNALKGRVPPGDSPPGNGSGPRHINDSPFGTLPGSAEPPLTAVRPEGSEPPGFPTSGPRRRPGCSRKNRTRSHCRLGQAGSGGGGTGDSEGSGALPSLTCSLTPLGLALVLWTVLGPC,negative +TTGGGGTGGGAGGGCGGGTTAACAAAGATAGCGCAACAGG,MSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEMLDRHHTHFCPLEGESWQDFLRNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAFLCQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERETPTTDSMPPLLRQAIELFDHQGAEPAFLFGLELIICGLEKQLKCESGS,negative +GGACGCGUGGUACCAGGCCGAUCUAUGGACGCUAUAGGGACACCGGAUACUUUAACGAUUGGCUAAGCUUCCGCGGGGAUC,MSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA,negative +ACACCCACCGCAGGCAGACGCAACGCCTCGGAGACTAGCC,MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPGPHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR,negative +TCCCACGCATTCTCCACATCATTTGAATAGTGTGGTCACTTCCAGTCCCGCAGGGCACACCCTTTCTGTCCTTCCGTCAC,VVIRSNNFTDNAKTIIVQLNESIAINCTRPNNNTRKSIHIGPGRAFYTTGDIIGNIRQAHCNLSRTKWENTLKQIAKKLREQFGNKTIVFNH,negative +CAGCGGGCATTTCTAGGGCCATCTTTAATCTTCTTTATGGAGAGCCTCGTTCACACGTTG,MKQYLNTVISNPRPAQALGINQPFVVFCFITSRALSFVPAIYWCFKCLHLAFVADKFKWLPLTSALWTLVSAYLSFVLANGFLLKWLIHYSIGPTIIRLFSLNVINFSFLSLSVSFITHGDNAYLLPAWIAISCFQTAAYIVQDWITSPIIRTLPFRSSSSSSSNYRHNLDFLEITVFAVVPVGIASFFTMVMLIWQLYKYPDSFLVSA,negative +GUAAACCGAAGUACUAGACUUGACCUAACA,MGVLLTQRTLLSLVLALLFPSMASMAAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQGLDVPKLREHCRERPGAFPSEETLRGLGRRGFLQTLNATLGCVLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILGLRNNIYCMAQLLDNSDTAEPTKAGRGASQPPTPTPASDAFQRKLEGCRFLHGYHRFMHSVGRVFSKWGESPNRSRRHSPHQALRKGVRRTRPSRKGKRLMTRGQLPR,negative +ACUGGCUAGCUAACCAAUGGUGGAUAUGAGUACCUUGGGC,MSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEMLDRHHTHFCPLEGESWQDFLRNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAFLCQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERETPTTDSMPPLLRQAIELFDHQGAEPAFLFGLELIICGLEKQLKCESGS,negative +GCTGCAGTTGCACTGAATTCGCCTCTCGCCTCCGTACACTTAGTCGACAGGATCCGCTGAACTGACCTG,IMEIRTVAVGIVAIKGVESEYYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHSGGEMFVALNQKGLPVKGKKTKKEQKTAHFLPMAIT,negative +GTAAATCGTCGACAGGAATTGGCGGGCCGG,MRKIVVAAIAVSLTTVSITASASADPSKDSKAQVSAAEAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKVKPSAASIDAAKKAGVNNGNPLDAVQQ,negative +CTCCTCTGACTGTAACCACGTGCCTAGCGTTTCATTGTCCCTTCTTATTAGGTGATAATAGCATAGGTAGTCCAGAAGCC,MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP,negative +GGTTGTGAAGATTGGGAGCGTCGTGGCTAC,MAGRSGDSDEELLKAVRLIKFLYQSNPPPNPEGTRQARRNRRRRWRERQRQIHSISERILSTYLGRSAEPVPLQLPPLERLTLDCNEDCGTSGTQGVGSPQILVESPTILESGAKE,negative +CAGCGAAAGUUGCGUAUGGGUCACAUCGCAGGCACAUGUCAUCUGGGCG,MRKIVVAAIAVSLTTVSITASASADPSKDSKAQVSAAEAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKVKPSAASIDAAKKAGVNNGNPLDAVQQ,negative +TCCCTACGGCGCTAACTTCTGCAAGAGGCCGTCAACGGGCGAGTTAGCCACCGTGCTACAAC,MEGMLKGEGPGPLPPLLQQYVELRDQYPDYLLLFQVGDFYECFGEDAERLARALGLVLTHKTSKDFTTPMAGIPLRAFEAYAERLLKMGFRLAVADQVEPAEEAEGLVRREVTQLLTPGTLLQESLLPREANYLAAIATGDGWGLAFLDVSTGEFKGTVLKSKSALYDELFRHRPAEVLLAPELLENGAFLDEFRKRFPVMLSEAPFEPEGEGPLALRRARGALLAYAQRTQGGALSLQPFRFYDPGAFMRLPEATLRALEVFEPLRGQDTLFSVLDETRTAPGRRLLQSWLRHPLLDRGPLEARLDRVEGFVREGALREGVRRLLYRLADLERLATRLELGRASPKDLGALRRSLQILPELRALLGEEVGLPDLSPLKEELEAALVEDPPLKVSEGGLIREGYDPDLDALRAAHREGVAYFLELEERERERTGIPTLKVGYNAVFGYYLEVTRPYYERVPKEYRPVQTLKDRQRYTLPEMKEKEREVYRLEALIRRREEEVFLEVRERAKRQAEALREAARILAELDVYAALAEVAVRYGYVRPRFGDRLQIRAGRHPVVERRTEFVPNDLEMAHELVLITGPNMAGKSTFLRQTALIALLAQVGSFVPAEEAHLPLFDGIYTRIGASDDLAGGKSTFMVEMEEVALILKEATENSLVLLDEVGRGTSSLDGVAIATAVAEALHERRAYTLFATHYFELTALGLPRLKNLHVAAREEAGGLVFYHQVLPGPASKSYGVEVAAMAGLPKEVVARARALLQAMAARREGALDAVLERLLALDPDRLTPLEALRLLQELKALALGAPLDTMKG,negative +ATATTAAAAATTATT,MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINYDEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQAVAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQGIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADMDFSALLSQISS,negative +GAAGCUUACAAGAAGGACAGCACGAAUAAAACCUGCGUAAAUCCGCCCCAUUUGUGUAAAAAAAAAAAAAAAAAAAAAAAAA,MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPGPHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR,negative +GGGAGGACGATGCGGGCGAAGGCACACCGAGTTCATAGTATCCCACAGACGACGAGCGGGA,MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNLERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCPFGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGRVSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVFHKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVEGTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT,negative +TACCAAGATCCCACAACTAGCCGACCACAATTGCCGGCCA,MARVRGPRLPGCLALAALFSLVHSQHVFLAHQQASSLLQRARRANKGFLEEVRKGNLERECLEEPCSREEAFEALESLSATDAFWAKYTACESARNPREKLNECLEGNCAEGVGMNYRGNVSVTRSGIECQLWRSRYPHKPEINSTTHPGADLRENFCRNPDGSITGPWCYTTSPTLRREECSVPVCGQDRVTVEVIPRSGGSTTSQSPLLETCVPDRGREYRGRLAVTTSGSRCLAWSSEQAKALSKDQDFNPAVPLAENFCRNPDGDEEGAWCYVADQPGDFEYCDLNYCEEPVDGDLGDRLGEDPDPDAAIEGRTSEDHFQPFFNEKTFGAGEADCGLRPLFEKKQVQDQTEKELFESYIEGRIVEGQDAEVGLSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTVDDLLVRIGKHSRTRYERKVEKISMLDKIYIHPRYNWKENLDRDIALLKLKRPIELSDYIHPVCLPDKQTAAKLLHAGFKGRVTGWGNRRETWTTSVAEVQPSVLQVVNLPLVERPVCKASTRIRITDNMFCAGYKPGEGKRGDACEGDSGGPFVMKSPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDRLGS,negative +GGGAGAGCGGAAGCGUGCUGGGCCUGUCGUUCGCUGUCUUGCUACGUUACGUUACACGGUUGGCAUAACCCAGAGGUCGAUGGAUCCCCCC,MDHLNEATQGKEHSEMSNNVSDPKGPPAKIARLEQNGSPLGRGRLGSTGAKMQGVPLKHSGHLMKTNLRKGTMLPVFCVVEHYENAIEYDCKEEHAEFVLVRKDMLFNQLIEMALLSLGYSHSSAAQAKGLIQVGKWNPVPLSYVTDAPDATVADMLQDVYHVVTLKIQLHSCPKLEDLPPEQWSHTTVRNALKDLLKDMNQSSLAKECPLSQSMISSIVNSTYYANVSAAKCQEFGRWYKHFKKTKDMMVEMDSLSELSQQGANHVNFGQQPVPGNTAEQPPSPAQLSHGSQPSVRTPLPNLHPGLVSTPISPQLVNQQLVMAQLLNQQYAVNRLLAQQSLNQQYLNHPPPVSRSMNKPLEQQVSTNTEVSSEIYQWVRDELKRAGISQAVFARVAFNRTQGLLSEILRKEEDPKTASQSLLVNLRAMQNFLQLPEAERDRIYQDERERSLNAASAMGPAPLISTPPSRPPQVKTATIATERNGKPENNTMNINASIYDEIQQEMKRAKVSQALFAKVAATKSQGWLCELLRWKEDPSPENRTLWENLSMIRRFLSLPQPERDAIYEQESNAVHHHGDRPPHIIHVPAEQIQQQQQQQQQQQQQQQAPPPPQPQQQPQTGPRLPPRQPTVASPAESDEENRQKTRPRTKISVEALGILQSFIQDVGLYPDEEAIQTLSAQLDLPKYTIIKFFQNQRYYLKHHGKLKDNSGLEVDVAEYKEEELLKDLEESVQDKNTNTLFSVKLEEELSVEGNTDINTDLKD,negative +CTTCTGCCCGCCTCCTTCCAGCCGTCACAGGTCGCTCATTCATTACGGTCTGTTTGCGGGAGACGAGATAGGCGGACACT,MSDRKKIEIDAIDKKLLIELLKDSRISLRRLAEEMNVSPATLHNRLMRLVQEGVVKGFTALIDYSKLGYPVTSILMIKVDGKHILEFEKEVSNLDNVVAVYDVVGEYDVMLIAKFRSIEDLDTFIKSLLKNPKIERTYTSIVLNVVKEDPRIKII,negative +CTTCTGCCCGCCTCCTTCCTCGGGGTTAGAACGTCGTGTAGGACTCCTATCGGTTTATGGAGACGAGATAGGCGGACACT,MGCRRTREGPSKAMIFPWKCQSTQRDLWNIFKLWGWTMLCCDFLAHHGTDCWTYHYSEKPMNWQRARRFCRDNYTDLVAIQNKAEIEYLEKTLPFSRSYYWIGIRKIGGIWTWVGTNKSLTEEAENWGDGEPNNKKNKEDCVEIYIKRNKDAGKWNDDACHKLKAALCYTASCQPWSCSGHGECVEIINNYTCNCDVGYYGPQCQFVIQCEPLEAPELGTMDCTHPLGNFSFSSQCAFSCSEGTNLTGIEETTCGPFGNWSSPEPTCQVIQCEPLSAPDLGIMNCSHPLASFSFTSACTFICSEGTELIGKKKTICESSGIWSNPSPICQKLDKSFSMIKEGDYNPLFIPVAVMVTAFSGLAFIIWLARRLKKGM,negative +CACCAGACCGACAUCAGCUUAUGGCCCCUCACCCACACCG,SESGFNLSCQCLGFGSGHFKCDSSKWCHDNGVNYKIGEKWDRQGENGQMMSCTCLGNGKGEF,negative +AAGGACAGCACGAAUAAAACCUGCGUAAAUCCGCCCCAUUUGUGUAAGGGUAGUGGG,MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA,negative +GUUCCAGGCGCGUUAGCAAAACCGCGGAUC,GLVKKAHEISVLCDAELALIIFSPKGKLYEYATDSKMEIILERYERYTYAEKALIASDPDVQGNWCHEYIKLKAKFEALNKSQRHLMGEQLDTLNQKELLQLETKLEGSLKNVRSRKTQLMLDSISELQEKGKSLQEQNTCLEKEILGKQKDKAPKQHVQWEKQNQPPPTSSAPMPFLIGDIHPTPNIRNFQGRTVADA,negative +GGGAGCTCAGAATAAACGCTCAAGGGTTGGGTGGGGAGGTTGTAGAATGCAGGGGTTCGACATGAGGCCCGGATC,MAGRSGDSDEELLKAVRLIKFLYQSNPPPNPEGTRQARRNRRRRWRERQRQIHSISERILSTYLGRSAEPVPLQLPPLERLTLDCNEDCGTSGTQGVGSPQILVESPTILESGAKE,negative +ACGAAGCUUGAUCCCGUUUGCCGGUCGAUCGCUUCGA,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,negative +AGGAUGGAUCGAGCGCUGGAGUCUGGAGAAUGUCAC,PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGKISKIGPENPYNTPVFAIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDESFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPXRXKNPEMVIYQYMDDLYVGSDLEIGQHRAKIEELRSHLLSWGFTTPDKKHQKEPPFLWMGYELHPDSWTVQPIELPEKDSWTVNE,negative +AUCAGUCCCCACUGCCCCCGCUUGCAGACA,MPSKKNGRSGPQPHKRWVFTLNNPSEDERKKIRELPISLFDYFIVGEEGNEEGRTPHLQGFANFVKKQTFNKVKWYLGARCHIEKAKGTDQQNKEYCSKEGNLLMECGAPRSQGQRSDLSTAVSTLLESGSLVTVAEQHPVTFVRNFRGLAELLKVSGKMQKRDWKTNVHVIVGPPGCGKSKWAANFADPETTYWKPPRNKWWDGYHGEEVVVIDDFYGWLPWDDLLRLCDRYPLTVETKGGTVPFLARSILITSNQTPLEWYSSAAVPAVEALYRRITSLVFWKNATEQSTEEGGQFVTLSPPCPEFPYEINY,negative +UGAGCCGGUCGGCAGUAAUGUGACACUGCGG,MQPLLLLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVLTAAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRRNRNVNPVALPRAQEGLRPGTLCTVAGWGRVSMRRGTDTLREVQLRVQRDRQCLRIFGSYDPRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSGVPPEVFTRVSSFLPWIRTTMRSFKLLDQMETPL,negative +GUAUAUAGUAUAGUAUUGGC,MIPPPRRSASSTPKDYRSSRDLQPWRGVSSGDAAETSQQSRHRRDAIADGGGRLKGAAQSSPSSGTRRSGPYAQGRAMPKNENIPKPGKQRLGPRKKKLSTLKKKILLDRLERWRDKQHEGALSTPSATASSEEAKCNNPFPLCPPGELSPPPSPPATICPAVVDKSTSYGQVGGANGERSVWAITIYNLVDQEDVEDDDDHAEIERDLWDMSSAFGVVRSVQVPRGTAVQVSDAEVSAAAAAGEPAAVAAKVAFATNAEAECARDGLNGRIVGGKPLLVRIHRCDGHFCGGVCPGDPDGSGLWRVAIENLIDEEDDLDDEDEYAEISANVSAMMGCYGKLVDVQVRRSSPSKGEVQEDVATRAATTAGATQAVVVTFGSLAEAEACVQGIKGCRVGGKELDAHVVLDSERVLPSNPAFKCDQEHAHSSDVAAAVAGQGDSMMKQEAGTEPSPCVDQDTAAAVASSTEWRVVIRGLIDEDDLQDDDDDYAEVCSDVTALVSSYGAVVGLDIPRGRETGSCCYGAEPGEAVVVFRSLQEAEACARGLSGRKVAGNILDAQVLTQPAPSQQGPLQGGASGTGPPVANRERKPAKECPLPQHQASSHQSCGKVPELDGSGPGMLRGFGNRVEDCCGRPKIACTDSDEPQAIAAAAPPGQSIEGPKTTALAKAGKRIQTKYQEAAALPKPPGVRGGLPNAYVNQPPDKEVNDLVFEMLQLLFKFQERARLSDPSKAKTRRRLVIGLREVLRGVKAKKVRLLIVAPNVDAVGGEGGLDDKVVEIIDKAREAEYPVVFALSKRKIGKALGKTIKVSAVGVYSFDGANEQQKQLKRRMETISSLPSPSPRQSDPPTDDALASPPSSSACGDSQDPAGKGSRV,negative +UUAACUCCCAACGCAUCAAUCCCGAUCCGUGACUCCGCC,QSVEESRGGLIKPTDTLTLTCTVSGFSLSSYGEVWDRQAPGNGLEYIGAIGNSGSTYYASWAKSRSTITRNTNLNTVTLKMTSLTAADTATYFCAR,negative +GGGCGAAUUCGAGCCUCAAGAGUAGCAACAGAAUUGGAUCCCGACCACUAAGAACCCGGCCUGUUACUCGGCGGAUCCUCU,VENLMVQELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFSHFRLFDENNDAAILILLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVN,negative +CTTCGGCTTCACAGCTTTGGAAAGGGTACAAATTAAACTA,MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICEVEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASSIVYKKEGEQVEFSFPLAFTVEKLTGSGELWWQAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLPQALPQYAGSGNLTLALEAKTGKLHQEVNLVVMRATQLQKNLTCEVWGPTSPKLMLSLKLENKEAKVSKREKAVWVLNPEAGMWQCLLSDSGQVLLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQAERMSQIKRLLSEKKTCQCPHRFQKTCSPI,negative +GGGAGCTCAGAATAAACGCTCAAGGATGGGTGGGTGGGGAGGTTGTAGACTGTATTTCGACATGAGGCCCGGATC,MKKRKVLIPLMALSTILVSSTGNLEVIQAEVKQENRLLNESESSSQGLLGYYFSDLNFQAPMVVTSSTTGDLSIPSSELENIPSENQYFQSAIWSGFIKVKKSDEYTFATSADNHVTMWVDDQEVINKASNSNKIRLEKGRLYQIKIQYQRENPTEKGLDFKLYWTDSQNKKEVISSDNLQLPELKQKSSNSRKKRSTSAGPTVPDRDNDGIPDSLEVEGYTVDVKNKRTFLSPWISNIHEKKGLTKYKSSPEKWSTASDPYSDFEKVTGRIDKNVSPEARHPLVAAYPIVHVDMENIILSKNEDQSTQNTDSQTRTISKNTSTSRTHTSEVHGNAEVHASFFDIGGSVSAGFSNSNSSTVAIDHSLSLAGERTWAETMGLNTADTARLNANIRYVNTGTAPIYNVLPTTSLVLGKNQTLATIKAKENQLSQILAPNNYYPSKNLAPIALNAQDDFSSTPITMNYNQFLELEKTKQLRLDTDQVYGNIATYNFENGRVRVDTGSNWSEVLPQIQETTARIIFNGKDLNLVERRIAAVNPSDPLETTKPDMTLKEALKIAFGFNEPNGNLQYQGKDITEFDFNFDQQTSQNIKNQLAELNATNIYTVLDKIKLNAKMNILIRDKRFHYDRNNIAVGADESVVKEAHREVINSSTEGLLLNIDKDIRKILSGYIVEIEDTEGLKEVINDRYDMLNISSLRQDGKTFIDFKKYNDKLPLYISNPNYKVNVYAVTKENTIINPSENGDTSTNGIKKILIFSKKGYEIG,negative +CTCCTCTGACTGTAACCACGCAGGCCAATAACTAGCAGGTTACTGTTCATCATTTCGCACGCATAGGTAGTCCAGAAGCC,MKTLLLLLLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAKEPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHSRFQPSQSSTYSQPGQSFSIQYGTGSLSGIIGADQVSAFATQVEGLTVVGQQFGESVTEPGQTFVDAEFDGILGLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSHFSGSLNWVPVTKQAYWQIALDNIQVGGTVMFCSEGCQAIVDTGTSLITGPSDKIKQLQNAIGAAPVDGEYAVECANLNVMPDVTFTINGVPYTLSPTAYTLLDFVDGMQFCSSGFQGLDIHPPAGPLWILGDVFIRQFYSVFDRGNNRVGLAPAVP,negative +AGUCUGAGUCAAAUUGUGCCACUCCCACUCCAAUUGCGU,QELLCAASLISDRWVLTAAHCLLYPPWDKNFTVNDILVRIGKYARSRYERNMEKISTLEKIIIHPGYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDKQIVTSLLQAGHKGRVTGWGNLKEMWTVNMNEVQPSVLQMVNLPLVERPICKASTGIRVTDNMFCAGYKPEEGKRGDACEGDSGGPFVMKNPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIRKMVDRFG,negative +CAUUGGCCAAUUCCUUGAAUCUCGACUGCUCGGUAGAAUAGACCUUACCA,MAIPKELLVLLLGIAILSKVAECAAFGSRRGLVETVFDVTRFGARPNTPADSTRGLMMAWRSACQSPGPAKVVIPPGTYTTGETIFQGPCTSPRPITIEIQGTLLSNTDMSLYTRAAWISIEHVDGIVITGGGTLNGQGKSSWQFADKSGSTPPLPSSLVFQTVRSSSIKNLNFVDAKGVHLKITDSSDISVSNIKITAPGDSPNTDGLHISDTINVNVTDSTIGTGDDCISIGDGNSNVYISNINCGPGHGISIGSLGKRLDETDVKGVTVRNCTFRGTTNGARIKTYMGSPSLQVSGVVYEDIILDNVKNPIVIDQHYHSKNRNEPSRVKLVDIHFRNIRGTTTSKIPVLLNCSEALPCEGVELVDIDLAPVGSIGPLLPATCQNAKTILNGKNNPPAC,negative +GGGACGCTGAGGCTTCTATGGTTCCC,MASNFTQFVLVDNGGTGDVTVAPSNFANGVAEWISSNSRSQAYKVTCSVRQSSAQNRKYTIKVEVPKVATQTVGGVELPVAAWRSYLNMELTIPIFATNSDCELIVKAMQGLLKDGNPIPSAIAANSGIY,negative +CAUGAGGUCUAUCACUGCAUCGACAGCUAGGCGGACAAUG,MSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEMLDRHHTHFCPLEGESWQDFLRNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAFLCQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERETPTTDSMPPLLRQAIELFDHQGAEPAFLFGLELIICGLEKQLKCESGS,negative +ATACCAGCTTATTCAATTACAGTAGTGAGGGGTCCGTCGTGGGGTAGTTGGGTCGTGGAGATAGTAAGTGCAATCT,MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP,negative +CACCUACUAGACCACUUUUUGAGCCGGUUUUUUCGGGAACUUGCCAA,MEGMLKGEGPGPLPPLLQQYVELRDQYPDYLLLFQVGDFYECFGEDAERLARALGLVLTHKTSKDFTTPMAGIPLRAFEAYAERLLKMGFRLAVADQVEPAEEAEGLVRREVTQLLTPGTLLQESLLPREANYLAAIATGDGWGLAFLDVSTGEFKGTVLKSKSALYDELFRHRPAEVLLAPELLENGAFLDEFRKRFPVMLSEAPFEPEGEGPLALRRARGALLAYAQRTQGGALSLQPFRFYDPGAFMRLPEATLRALEVFEPLRGQDTLFSVLDETRTAPGRRLLQSWLRHPLLDRGPLEARLDRVEGFVREGALREGVRRLLYRLADLERLATRLELGRASPKDLGALRRSLQILPELRALLGEEVGLPDLSPLKEELEAALVEDPPLKVSEGGLIREGYDPDLDALRAAHREGVAYFLELEERERERTGIPTLKVGYNAVFGYYLEVTRPYYERVPKEYRPVQTLKDRQRYTLPEMKEKEREVYRLEALIRRREEEVFLEVRERAKRQAEALREAARILAELDVYAALAEVAVRYGYVRPRFGDRLQIRAGRHPVVERRTEFVPNDLEMAHELVLITGPNMAGKSTFLRQTALIALLAQVGSFVPAEEAHLPLFDGIYTRIGASDDLAGGKSTFMVEMEEVALILKEATENSLVLLDEVGRGTSSLDGVAIATAVAEALHERRAYTLFATHYFELTALGLPRLKNLHVAAREEAGGLVFYHQVLPGPASKSYGVEVAAMAGLPKEVVARARALLQAMAARREGALDAVLERLLALDPDRLTPLEALRLLQELKALALGAPLDTMKG,negative +ATCGATGACCCGTAGTGCAGTGAATTACGT,MHRPQRQQWIANGCAPKWRAMMRLAAAVAVLVVVTTLATAATAAGAKNEHQQQQQQQAWMESFPPMSADFPAGPALSDAEAAFLQVPEAERCRAHLKYLTSLPHVAGTPGDYETAEYVLNQFKSFGLDAVIQNETVLLTAPVEAASAKLYSADGTTLVYAAALSEDLLDPTADTPYRNHSFLGYSPTGSAAGPLVYVNYGSTEDFEYLVAQGVNLTGAIAIARYGSIFRGLKALNAQTHGMAGLIIYSDPSDDGYAQGQLYPNGPWRPESGIQRGSVVFNSLCGGDPGRGVDKCGIPLEDLIPSIPVLPMGYGDAVQFLSHIVGAPAPASWQGALPFQYNIGPGAFARIATNNTQYTTDIWNVVAYINGTDPVEGEDYVILGNHRDAWVYGAVDPNSGTAALLEIARAYGVLLQGGWQPKRGLVLTSWDGEEYGLLGSTAFGERFADDLILHAVAYLNIDTAVMGPQLWVTLVPSLLTHFRQTAALVKDPVTGNPLSVEWDGSYDIMGSGSDYTVFLDALGVASGDLLFGGAYGVYHSVFDSFNWMETQGDPTFQYHEACAQIFGLVGLRLADARILPFNYTEYAYAISTFYLPQVQQLATDAKLPVDFTALTNAAQQFASGASKIMSRVEQAYNNPNYNVVDLNSRLFLAERQFTDPNGIINRKWFKHTVFAPDRENGYDASSFPGIVDMIRTGNATLAQQAITSAATALSNVGTFLSY,negative +UUGUAAUGUAUACCGCGCGCCC,QSVEESRGGLIKPTDTLTLTCTVSGFSLSSYGEVWDRQAPGNGLEYIGAIGNSGSTYYASWAKSRSTITRNTNLNTVTLKMTSLTAADTATYFCAR,negative +TTATGGGGATGAAAGTGGTGTTCGGGTTCGCCACTTCCAC,MSARGEEAAGEASGSQEQPEPALAEPKKRGPGRPRKPQQEPTGEPVPKRPRGRPKGSKNKGPSKAAQKKAETTGEKRPRGRPRKWPQQVVQEKPAQEEEEEEEEEEAEED,negative +CAGCTCAGAAGCTTGATCCTGTGCGATCGAATGAAAGCTGCTGGATTGTCGCTATCCTGACTCGAAGTCGTGCATCTGCA,MSGGDGRGHNTGAHSTSGNINGGPTGLGVGGGASDGSGWSSENNPWGGGSGSGIHWGGGSGHGNGGGNGNSGGGSGTGGNLSAVAAPVAFGFPALSTPGAGGLAVSISAGALSAAIADIMAALKGPFKFGLWGVALYGVLPSQIAKDDPNMMSKIVTSLPADDITESPVSSLPLDKATVNVNVRVVDDVKDERQNISVVSGVPMSVPVVDAKPTERPGVFTASIPGAPVLNISVNNSTPAVQTLSPGVTNNTDKDVRPAGFTQGGNTRDAVIRFPKDSGHNAVYVSVSDVLSPDQVKQRQDEENRRQQEWDATHPVEAAERNYERARAELNQANEDVARNQERQAKAVQVYNSRKSELDAANKTLADAIAEIKQFNRFAHDPMAGGHRMWQMAGLKAQRAQTDVNNKQAAFDAAAKEKSDADAALSSAMESRKKKEDKKRSAENNLNDEKNKPRKGFKDYGHDYHPAPKTENIKGLGDLKPGIPKTPKQNGGGKRKRWTGDKGRKIYEWDSQHGELEGYRASDGQHLGSFDPKTGNQLKGPDPKRNIKKYL,negative +GGACCGAGAAGUUACCCUGUAAUCUUAGGAUGAAUCGCAUGCUCUAGCGACCUUUUCGGCUUCGGCGUACGCACAUCGCAGCAAC,MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA,negative +GGACCUUUGUACCCCAGAUGAUAGUAAGGCGCGGCUUGAUGGGUACAAAUGGCAG,MSEAEARPTNFIRQIIDEDLASGKHTTVHTRFPPEPNGYLHIGHAKSICLNFGIAQDYKGQCNLRFDDTNPVKEDIEYVESIKNDVEWLGFHWSGNVRYSSDYFDQLHAYAIELINKGLAYVDELTPEQIREYRGTLTQPGKNSPYRDRSVEENLALFEKMRAGGFEEGKACLRAKIDMASPFIVMRDPVLYRIKFAEHHQTGNKWCIYPMYDFTHCISDALEGITHSLCTLEFQDNRRLYDWVLDNITIPVHPRQYEFSRLNLEYTVMSKRKLNLLVTDKHVEGWDDPRMPTISGLRRRGYTAASIREFCKRIGVTKQDNTIEMASLESCIREDLNENAPRAMAVIDPVKLVIENYQGEGEMVTMPNHPNKPEMGSRQVPFSGEIWIDRADFREEANKQYKRLVLGKEVRLRNAYVIKAERVEKDAEGNITTIFCTYDADTLSKDPADGRKVKGVIHWVSAAHALPVEIRLYDRLFSVPNPGAADDFLSVINPESLVIKQGFAEPSLKDAVAGKAFQFEREGYFCLDSRHSTAEKPVFNRTVGLRDTWAKVGE,negative +BAGCGCCGGTGGTGGTGGGGGTTGTTGTTACGCGGTATTAT,MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA,negative +GACAGCGUGCCUAGAAGUCCAAGCUUAAAUAACCACGCUCGACAAGC,QDRPIKFSTEGATSQSYKQFIEALRERLRGGLIHDIPVLPDPTTLQERNRYITVELSNSDTESIEVGIDVTNAYVVAYRAGTQSYFLRDAPSSASDYLFTGTDQHSLPFYGTYGDLERWAHQSRQQIPLGLQALTHGISFFRSGGNDNEEKARTLIVIIQMVAEAARFRYISNRVRVSIQTGTAFQPDAAMISLENNWDNLSRGVQESVQDTFPNQVTLTNIRNEPVIVDSLSHPTVAVLALMLFVCNPPNANQSPLLIRSIVEKSKICSSRYEPTVRIGGRDGMCVDVYDNGYHNGNRIIMWKCKDRLEENQLWTLKSDKTIRSNGKCLTTYGYAPGSYVMIYDCTSAVAEATYWEIWDNGTIINPKSALVLSAESSSMGGTLTVQTNEYLMRQGWRTGNNTSPFVTSISGYSDLCMQAQGSNVWMADCDSNKKEQQWALYTDGSIRSVQNTNNCLTSKDHKQGSTILLMGCSNGWASQRWVFKNDGSIYSLYDDMVMDVKGSDPSLKQIILWPYTGKPNQIWLTLF,negative +GGCAGCGAGAGCAAAACAAGUAUGAGACCCAGCUACGGCGACUUCUCAUGCGUAGCCAAACCCA,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +AUCGCCCUGAACCGGCCCAGCAGACUGCUGACGGAACGAC,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,negative +CAGGAGGCTACTGTCCCTGGGC,MSARGEEAAGEASGSQEQPEPALAEPKKRGPGRPRKPQQEPTGEPVPKRPRGRPKGSKNKGPSKAAQKKAETTGEKRPRGRPRKWPQQVVQEKPAQEEEEEEEEEEAEED,negative +AGCAGCACAGAGGTCAGATGGTTCGTTGTAGCGCATAAAGTTTATCTCTCCCATGATTCACCTATGCGTGCTACCGTGAA,MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA,negative +AUCGCCCUGAACCGGCCCAGCAGACUGCUGACGGCACGAU,MSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEMLDRHHTHFCPLEGESWQDFLRNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAFLCQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERETPTTDSMPPLLRQAIELFDHQGAEPAFLFGLELIICGLEKQLKCESGS,negative +AATCCCAATGGATTGAACTGCCAACGAACG,WPLTEEKIKALVEICXEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEEFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDXIIYQYMDDLYVGSDLEIGQHRTKVEELRQHLLXWGFTTPDKKHQKEPPFLWMGYELHP,negative +CAGCTCAGAAGCTTGATCCTGTGAAGGGCTGATGAGGGGCGTAGCGGCTTGTTCGTAAGACTCGAAGTCGTGCATCTGCA,MGLLGILCFLIFLGKTWGQEQTYVISAPKIFRVGASENIVIQVYGYTEAFDATISIKSYPDKKFSYSSGHVHLSSENKFQNSAILTIQPKQLPGGQNPVSYVYLEVVSKHFSKSKRMPITYDNGFLFIHTDKPVYTPDQSVKVRVYSLNDDLKPAKRETVLTFIDPEGSEVDMVEEIDHIGIISFPDFKIPSNPRYGMWTIKAKYKEDFSTTGTAYFEVKEYVLPHFSVSIEPEYNFIGYKNFKNFEITIKARYFYNKVVTEADVYITFGIREDLKDDQKEMMQTAMQNTMLINGIAQVTFDSETAVKELSYYSLEDLNNKYLYIAVTVIESTGGFSEEAEIPGIKYVLSPYKLNLVATPLFLKPGIPYPIKVQVKDSLDQLVGGVPVTLNAQTIDVNQETSDLDPSKSVTRVDDGVASFVLNLPSGVTVLEFNVKTDAPDLPEENQAREGYRAIAYSSLSQSYLYIDWTDNHKALLVGEHLNIIVTPKSPYIDKITHYNYLILSKGKIIHFGTREKFSDASYQSINIPVTQNMVPSSRLLVYYIVTGEQTAELVSDSVWLNIEEKCGNQLQVHLSPDADAYSPGQTVSLNMATGMDSWVALAAVDSAVYGVQRGAKKPLERVFQFLEKSDLGCGAGGGLNNANVFHLAGLTFLTNANADDSQENDEPCKEILRPRRTLQKKIEEIAAKYKHSVVKKCCYDGACVNNDETCEQRAARISLGPRCIKAFTECCVVASQLRANISHKDMQLGRLHMKTLLPVSKPEIRSYFPESWLWEVHLVPRRKQLQFALPDSLTTWEIQGVGISNTGICVADTVKAKVFKDVFLEMNIPYSVVRGEQIQLKGTVYNYRTSGMQFCVKMSAVEGICTSESPVIDHQGTKSSKCVRQKVEGSSSHLVTFTVLPLEIGLHNINFSLETWFGKEILVKTLRVVPEGVKRESYSGVTLDPRGIYGTISRRKEFPYRIPLDLVPKTEIKRILSVKGLLVGEILSAVLSQEGINILTHLPKGSAEAELMSVVPVFYVFHYLETGNHWNIFHSDPLIEKQKLKKKLKEGMLSIMSYRNADYSYSVWKGGSASTWLTAFALRVLGQVNKYVEQNQNSICNSLLWLVENYQLDNGSFKENSQYQPIKLQGTLPVEARENSLYLTAFTVIGIRKAFDICPLVKIDTALIKADNFLLENTLPAQSTFTLAISAYALSLGDKTHPQFRSIVSALKREALVKGNPPIYRFWKDNLQHKDSSVPNTGTARMVETTAYALLTSLNLKDINYVNPVIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVKQLRLSMDIDVSYKHKGALHNYKMTDKNFLGRPVEVLLNDDLIVSTGFGSGLATVHVTTVVHKTSTSEEVCSFYLKIDTQDIEASHYRGYGNSDYKRIVACASYKPSREESSSGSSHAVMDISLPTGISANEEDLKALVEGVDQLFTDYQIKDGHVILQLNSIPSSDFLCVRFRIFELFEVGFLSPATFTVYEYHRPDKQCTMFYSTSNIKIQKVCEGAACKCVEADCGQMQEELDLTISAETRKQTACKPEIAYAYKVSITSITVENVFVKYKATLLDIYKTGEAVAEKDSEITFIKKVTCTNAELVKGRQYLIMGKEALQIKYNFSFRYIYPLDSLTWIEYWPRDTTCSSCQAFLANLDEFAEDIFLNGC,negative +GUAUUCUCGGUGGUUUAAUCAGAGUAGAGGAGGCUGACUCCUUUGGUUGGACGACGGUGGAGGUUCUUCUUG,AKVLVVLLLFAGVDAETHVTGGSAAHAASTFAGLFSPGAKQDIQLINTNGSWHINRTA,negative +CCACCACCACAACAAAACTCCAC,MAGRSGDSDEELLKAVRLIKFLYQSNPPPNPEGTRQARRNRRRRWRERQRQIHSISERILSTYLGRSAEPVPLQLPPLERLTLDCNEDCGTSGTQGVGSPQILVESPTILESGAKE,negative +UAUAUAUGUGUGUCUAUCGUCACUUGUAUGUCAAAUAUU,MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC,negative +CTTGCAAAATTTGCAACTGTGTG,MGVLLTQRTLLSLVLALLFPSMASMAAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQGLDVPKLREHCRERPGAFPSEETLRGLGRRGFLQTLNATLGCVLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILGLRNNIYCMAQLLDNSDTAEPTKAGRGASQPPTPTPASDAFQRKLEGCRFLHGYHRFMHSVGRVFSKWGESPNRSRRHSPHQALRKGVRRTRPSRKGKRLMTRGQLPR,negative +CACGGTAGTGCTACCAGATGGTTATGTTACTTCAATTCTG,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +AAGACGGCCGGGGAAACCCGAGAUCCGAGGUAACGC,MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQRGLKNVFDEAILAALEPPETQPKRKCCIF,negative +AGGCAGAGAAGAGUGGGUGCGACCACAGGAUGUUAUGG,MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC,negative +TCCCACGCATTCTCCACATCGAGGAGTATCGGGGCACGATCCTATTTAAGGCCGATAACCCCTTTCTGTCCTTCCGTCAC,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,negative +GCCCGAUCUACUGCAUUACCGAAACGAUUUCCCCACUGU,MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQRGLKNVFDEAILAALEPPETQPKRKCCIF,negative +GGGACACAAUGGACGAAGUCAGUCGCAUUGGCCGAGCUGUCGCUCUGACCAACUGAUAACGGCCGACAUGAGAG,MSPQRDRINAFYKDNPHPKGSRIVINREHLMIDRPYVLLAVLFVMFLSLIGLLAIAGIRLHRAAIYTAEIHKSLSTNLDVTNSIEHQVKDVLTPLFKIIGDEVGLRTPQRFTDLVKFISDKIKFLNPDREYDFRDLTWCINPPERIKLDYDQYCADVAAEELMNALVNSTLLEARATNQFLAVSKGNCSGPTTIRGQFSNMSLSLLDLYLSRGYNVSSIVTMTSQGMYGGTYLVEKPNLSSKGSELSQLSMHRVFEVGVIRNPGLGAPVFHMTNYFEQPVSNDFSNCMVALGELKFAALCHREDSITIPYQGSGKDVSFQLVKLGVWKSPTDMQSWVPLSTDDPVIDRLYLSSHRGVIADNQAKWAVPTTRTDDKLRMETCFQQACKGKIQALCENPDWAPLKDNRIPSYGVLSVNLSLTVELKIKIASGFGPLITHGSGMDLYKSNHNNMYWLTIPPMKNLALGVINTLEWIPRFRVSPNLFTVPIKEAGEDCHAPTYLPAEVDGDVKLSSNLVILPGQDLQYVLATYDTSRVEHAVVYYVYSPSRSFSYFYPFRLPIKGVPIELQVECFTWDQKLWCRHFCVLADSGSGGHITHSGMVGMGVSCTVTREDGTNRR,negative +GGGAGAAGGGAAGTAACAGGUUUCGUGCCUUUUCUCGAUGGAGUGAGAAGAGGTGACGGTACCAG,MPSKKNGRSGPQPHKRWVFTLNNPSEDERKKIRELPISLFDYFIVGEEGNEEGRTPHLQGFANFVKKQTFNKVKWYLGARCHIEKAKGTDQQNKEYCSKEGNLLMECGAPRSQGQRSDLSTAVSTLLESGSLVTVAEQHPVTFVRNFRGLAELLKVSGKMQKRDWKTNVHVIVGPPGCGKSKWAANFADPETTYWKPPRNKWWDGYHGEEVVVIDDFYGWLPWDDLLRLCDRYPLTVETKGGTVPFLARSILITSNQTPLEWYSSAAVPAVEALYRRITSLVFWKNATEQSTEEGGQFVTLSPPCPEFPYEINY,negative +GCUAUCAUCAUUAACUUUAUUUAUUACCGUCAUUCAUUUCUGAAUGUCUGUUUACCCCUAUUUCAACCGGUUUUUUUU,PGGVQVSLLKEYYEDGYHIVRDIDSTVGVSISDASLPPRTWNGFLAPKTYKNVYIDTYHNQVFDDIFRTFTIDQHVKLACSLPHGRLRGADKPLIVKEWSGAMTDCAMYLNGRGIGSRFDGSFPSGKPSGACGARSKGSSSELSAQQKKDTLRYIEAQLDAFEVGAGWYFWTW,negative +CAACGTGTGATATGTGGGTATACGCTTGGGTGTTACGCTGAGCACAGAGGGTATTCGTGT,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,negative +ACAAAUCCCCAGGAGUGCAAUACUCCGCAA,QELLCAASLISDRWVLTAAHCLLYPPWDKNFTVNDILVRIGKYARSRYERNMEKISTLEKIIIHPGYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDKQIVTSLLQAGHKGRVTGWGNLKEMWTVNMNEVQPSVLQMVNLPLVERPICKASTGIRVTDNMFCAGYKPEEGKRGDACEGDSGGPFVMKNPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIRKMVDRFG,negative +UGUUGUUGGACCAGUGUUAUUUUACGCGAUUGUGCGGUUGUGA,MDHLNEATQGKEHSEMSNNVSDPKGPPAKIARLEQNGSPLGRGRLGSTGAKMQGVPLKHSGHLMKTNLRKGTMLPVFCVVEHYENAIEYDCKEEHAEFVLVRKDMLFNQLIEMALLSLGYSHSSAAQAKGLIQVGKWNPVPLSYVTDAPDATVADMLQDVYHVVTLKIQLHSCPKLEDLPPEQWSHTTVRNALKDLLKDMNQSSLAKECPLSQSMISSIVNSTYYANVSAAKCQEFGRWYKHFKKTKDMMVEMDSLSELSQQGANHVNFGQQPVPGNTAEQPPSPAQLSHGSQPSVRTPLPNLHPGLVSTPISPQLVNQQLVMAQLLNQQYAVNRLLAQQSLNQQYLNHPPPVSRSMNKPLEQQVSTNTEVSSEIYQWVRDELKRAGISQAVFARVAFNRTQGLLSEILRKEEDPKTASQSLLVNLRAMQNFLQLPEAERDRIYQDERERSLNAASAMGPAPLISTPPSRPPQVKTATIATERNGKPENNTMNINASIYDEIQQEMKRAKVSQALFAKVAATKSQGWLCELLRWKEDPSPENRTLWENLSMIRRFLSLPQPERDAIYEQESNAVHHHGDRPPHIIHVPAEQIQQQQQQQQQQQQQQQAPPPPQPQQQPQTGPRLPPRQPTVASPAESDEENRQKTRPRTKISVEALGILQSFIQDVGLYPDEEAIQTLSAQLDLPKYTIIKFFQNQRYYLKHHGKLKDNSGLEVDVAEYKEEELLKDLEESVQDKNTNTLFSVKLEEELSVEGNTDINTDLKD,negative +AATACGACTCACTATAGAGGGAGGACGATGCGGGATGGACGCTTATCCGCATAGAGGTTTACTACTTCGGAGACTGCCGATACAGACGACGGA,VVIRSNNFTDNAKTIIVQLNESIAINCTRPNNNTRKSIHIGPGRAFYTTGDIIGNIRQAHCNLSRTKWENTLKQIAKKLREQFGNKTIVFNH,negative +AGGAGAAUUAUGAGCGGGACAACUUCGUUCCGUGUUCGCGUACUGAGCGC,MPSNQEARLFLAVLVLAQVLPILVDSAAEKGFKQAFWQPLCQVSEELDDQPKGALFTLQAAASKIQKMRDAALRASIYAEINHGTNRAKAAVIVANHYAMKADSGLEALKQTLSSQEVTATATASYLKGRIDEYLNLLLQTKESGTSGCMMDTSGTNTVTKAGGTIGGVPCKLQLSPIQPKRPAATYLGKAGYVGLTRQADAANNFHDNDAECRLASGHNTNGLGKSGQLSAAVTMAAGYVTVANSQTAVTVQALDALQEASGAAHQPWIDAWKAKKALTGAETAEFRNETAGIAGKTGVTKLVEEALLKKKDSEASEIQTELKKYFSGHENEQWTAIEKLISEQPVAQNLVGDNQPTKLGELEGNAKLTTILAYYRMETAGKFEVLTQKHKPAESQQQAAETEGSCNKKDQNECKSPCKWHNDAENKKCTLDKEEAKKVADETAKDGKTGNTNTTGSSNSFVISKTPLWLAVLLF,negative +AUUUCUCUGAGAUGUUCGCAAGCGGGCCAGUCCCCUGAGCCGAUAUUUCAUACCACAAGAAAUGUGGCGCUCCGCGGUUGGUGAGCAUGCUCGGUCCGUCCGAGAAGCCUUAAAACUGCGACGACACAUUCACCUUGAACCAAGGGUUCAAGGGUUACAGCCUGCGGCGGCAUCUCGGAGAUUCC,MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC,negative +AGCAACCU,MGVLLTQRTLLSLVLALLFPSMASMAAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQGLDVPKLREHCRERPGAFPSEETLRGLGRRGFLQTLNATLGCVLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILGLRNNIYCMAQLLDNSDTAEPTKAGRGASQPPTPTPASDAFQRKLEGCRFLHGYHRFMHSVGRVFSKWGESPNRSRRHSPHQALRKGVRRTRPSRKGKRLMTRGQLPR,negative +GGATGATGCCGCACTGACGCCACGTAGGTGGCGCACAGCC,PGGVQVSLLKEYYEDGYHIVRDIDSTVGVSISDASLPPRTWNGFLAPKTYKNVYIDTYHNQVFDDIFRTFTIDQHVKLACSLPHGRLRGADKPLIVKEWSGAMTDCAMYLNGRGIGSRFDGSFPSGKPSGACGARSKGSSSELSAQQKKDTLRYIEAQLDAFEVGAGWYFWTW,negative +ACACCCUCAACAAGUCCCGCCAACAACGC,MDHLNEATQGKEHSEMSNNVSDPKGPPAKIARLEQNGSPLGRGRLGSTGAKMQGVPLKHSGHLMKTNLRKGTMLPVFCVVEHYENAIEYDCKEEHAEFVLVRKDMLFNQLIEMALLSLGYSHSSAAQAKGLIQVGKWNPVPLSYVTDAPDATVADMLQDVYHVVTLKIQLHSCPKLEDLPPEQWSHTTVRNALKDLLKDMNQSSLAKECPLSQSMISSIVNSTYYANVSAAKCQEFGRWYKHFKKTKDMMVEMDSLSELSQQGANHVNFGQQPVPGNTAEQPPSPAQLSHGSQPSVRTPLPNLHPGLVSTPISPQLVNQQLVMAQLLNQQYAVNRLLAQQSLNQQYLNHPPPVSRSMNKPLEQQVSTNTEVSSEIYQWVRDELKRAGISQAVFARVAFNRTQGLLSEILRKEEDPKTASQSLLVNLRAMQNFLQLPEAERDRIYQDERERSLNAASAMGPAPLISTPPSRPPQVKTATIATERNGKPENNTMNINASIYDEIQQEMKRAKVSQALFAKVAATKSQGWLCELLRWKEDPSPENRTLWENLSMIRRFLSLPQPERDAIYEQESNAVHHHGDRPPHIIHVPAEQIQQQQQQQQQQQQQQQAPPPPQPQQQPQTGPRLPPRQPTVASPAESDEENRQKTRPRTKISVEALGILQSFIQDVGLYPDEEAIQTLSAQLDLPKYTIIKFFQNQRYYLKHHGKLKDNSGLEVDVAEYKEEELLKDLEESVQDKNTNTLFSVKLEEELSVEGNTDINTDLKD,negative +GGGAGAAUUCAACUGCCAUCUAUAGAAGAUGAUGCCUGGAUACAAUACAGCCACUCCUCGACUGUAAACCGAGUCCAGAAGCUUGUAGU,MHRPQRQQWIANGCAPKWRAMMRLAAAVAVLVVVTTLATAATAAGAKNEHQQQQQQQAWMESFPPMSADFPAGPALSDAEAAFLQVPEAERCRAHLKYLTSLPHVAGTPGDYETAEYVLNQFKSFGLDAVIQNETVLLTAPVEAASAKLYSADGTTLVYAAALSEDLLDPTADTPYRNHSFLGYSPTGSAAGPLVYVNYGSTEDFEYLVAQGVNLTGAIAIARYGSIFRGLKALNAQTHGMAGLIIYSDPSDDGYAQGQLYPNGPWRPESGIQRGSVVFNSLCGGDPGRGVDKCGIPLEDLIPSIPVLPMGYGDAVQFLSHIVGAPAPASWQGALPFQYNIGPGAFARIATNNTQYTTDIWNVVAYINGTDPVEGEDYVILGNHRDAWVYGAVDPNSGTAALLEIARAYGVLLQGGWQPKRGLVLTSWDGEEYGLLGSTAFGERFADDLILHAVAYLNIDTAVMGPQLWVTLVPSLLTHFRQTAALVKDPVTGNPLSVEWDGSYDIMGSGSDYTVFLDALGVASGDLLFGGAYGVYHSVFDSFNWMETQGDPTFQYHEACAQIFGLVGLRLADARILPFNYTEYAYAISTFYLPQVQQLATDAKLPVDFTALTNAAQQFASGASKIMSRVEQAYNNPNYNVVDLNSRLFLAERQFTDPNGIINRKWFKHTVFAPDRENGYDASSFPGIVDMIRTGNATLAQQAITSAATALSNVGTFLSY,negative +AGCCGCGAGGGGAGGGAUAGGGUAGGGCGCGGCU,MLNQLDNLTERVRGSNKLVDRWLHVRKHLLVAYYNLVGIKPGKESYMRLNEKALDDFCQSLVDYLSAGHFSIYERILHKLEGNGQLARAAKIWPQLEANTQQIMDYYDSSLETAIDHDNYLEFQQVLSDIGEALEARFVLEDKLILLVLDAARVKHPA,negative +AAGCTCTTAGTTGATGCGCGGTCAAAATTTAAGCT,MHGDTPTLHEYMLDLQPETTDLYCYEQLNDSSEEEDEIDGPAGQAEPDRAHYNIVTFCCKCDSTLRLCVQSTHVDIRTLEDLLMGTLGIVCPICSQKP,negative +TCCCACGCATTCTCCACATCTAGTCTGGTTACGGTCTCGATTGTCCCAAAAGGGCAGACACCTTTCTGTCCTTCCGTCAC,MKRASAGGSRLLAWVLWLQAWQVAAPCPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDNPWVCDCRARPLWAWLQKFRGSSSEVPCSLPQRLAGRDLKRLAANDLQGCAVATGPYHPIWTGRATDEEPLGLPKCCQPDAADKASVLEPGRPASAGNALKGRVPPGDSPPGNGSGPRHINDSPFGTLPGSAEPPLTAVRPEGSEPPGFPTSGPRRRPGCSRKNRTRSHCRLGQAGSGGGGTGDSEGSGALPSLTCSLTPLGLALVLWTVLGPC,negative +GAUGUUUCGAAUGUUGCGGGUGAGACACAGCAUGACAAACUACCGUGUCA,MEGMLKGEGPGPLPPLLQQYVELRDQYPDYLLLFQVGDFYECFGEDAERLARALGLVLTHKTSKDFTTPMAGIPLRAFEAYAERLLKMGFRLAVADQVEPAEEAEGLVRREVTQLLTPGTLLQESLLPREANYLAAIATGDGWGLAFLDVSTGEFKGTVLKSKSALYDELFRHRPAEVLLAPELLENGAFLDEFRKRFPVMLSEAPFEPEGEGPLALRRARGALLAYAQRTQGGALSLQPFRFYDPGAFMRLPEATLRALEVFEPLRGQDTLFSVLDETRTAPGRRLLQSWLRHPLLDRGPLEARLDRVEGFVREGALREGVRRLLYRLADLERLATRLELGRASPKDLGALRRSLQILPELRALLGEEVGLPDLSPLKEELEAALVEDPPLKVSEGGLIREGYDPDLDALRAAHREGVAYFLELEERERERTGIPTLKVGYNAVFGYYLEVTRPYYERVPKEYRPVQTLKDRQRYTLPEMKEKEREVYRLEALIRRREEEVFLEVRERAKRQAEALREAARILAELDVYAALAEVAVRYGYVRPRFGDRLQIRAGRHPVVERRTEFVPNDLEMAHELVLITGPNMAGKSTFLRQTALIALLAQVGSFVPAEEAHLPLFDGIYTRIGASDDLAGGKSTFMVEMEEVALILKEATENSLVLLDEVGRGTSSLDGVAIATAVAEALHERRAYTLFATHYFELTALGLPRLKNLHVAAREEAGGLVFYHQVLPGPASKSYGVEVAAMAGLPKEVVARARALLQAMAARREGALDAVLERLLALDPDRLTPLEALRLLQELKALALGAPLDTMKG,negative +TTGACCGCT-GTGTGACGCAACACTCAATTTCTTCCAGCCGGTCCG,MASTSRLDALPRVTCPNHPDAILVEDYRAGDMICPECDRVIDVGSEWRTFSNDKATKDPSRVGDSQNPLLSDGDLSTMIGKGTGAASFDEFGNSKYQNRRTMSSSDRAMMNAFKEITTMADRINLPRNIVDRTNNLFKQVYEQKSLKGRANDAIASACLYIACRQEGVPRTFKEICAVSRISKKEIGRCFKLILKALETSVDLITTGDFMSRFCSNLCLPKQVQMAATHIA,negative +TTCCGGCTATGGTTAAACAAAAGACTAGGGAGGTTATTCA,MHGDTPTLHEYMLDLQPETTDLYCYEQLNDSSEEEDEIDGPAGQAEPDRAHYNIVTFCCKCDSTLRLCVQSTHVDIRTLEDLLMGTLGIVCPICSQKP,negative +CCACAGUCACUGGG,MKTLLLLLLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAKEPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHSRFQPSQSSTYSQPGQSFSIQYGTGSLSGIIGADQVSAFATQVEGLTVVGQQFGESVTEPGQTFVDAEFDGILGLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSHFSGSLNWVPVTKQAYWQIALDNIQVGGTVMFCSEGCQAIVDTGTSLITGPSDKIKQLQNAIGAAPVDGEYAVECANLNVMPDVTFTINGVPYTLSPTAYTLLDFVDGMQFCSSGFQGLDIHPPAGPLWILGDVFIRQFYSVFDRGNNRVGLAPAVP,negative +ACAAAGCUGGAGUACUUACCGAACAUCCGUCUAACCCCU,MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA,negative +GCAACAGAGGCUGAUGGUAGACGCCGGCCA,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,negative +CAUUGGCCAAUUCCUUGAAUCUCGACUGCUCGGUAGAAUAGACCUUACCA,IMEIRTVAVGIVAIKGVESEYYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHSGGEMFVALNQKGLPVKGKKTKKEQKTAHFLPMAIT,negative +GGGAGGACGAUGCGGAUCAGCCAUGUUUACGUCACUCCUUGUCAAUCCUCAUCGGCAGACGACUCGCCCGA,MDSTNYISKLFEYAQRQGQISDIKFEEVGTDGPDHLKTFTLRVVIKGHAYPNGVGKTKKEAKRNAAKHALIGMMETTEQKDASVSCPPSPAPSPAPPVRAVISQPKYVSWLNEHSQKNKLSLKALEGARVGPNNTSQCCRYVVGEKEYPEGFGNTKKEAKEEAAMQVYLELCGGSQTTGTVDENCNGTTGKHKEELNGKVVVLSEKVEHMNMSPAQNVPEQYSFITTEETNFIGILNHYCQKTKRFLDFKLVEKSGPSHNPQFVYKVLIDKREYPDGLGKTAKEAKQQAAQLAWSALQEQSDWNSQVSCRSTVSEEGGLSSLTPSSTWESQDATPSSLSIAGSTSESIIFSDSVNVSSPKDESPVNVKPKIRLAANFQMSPVKTKQEGPNLKGNDLGTLSSGRTSNQPVISRFSSEFDSIENIGKGGFGHVYKARRKLEQKYFAVKIVRSKGKAKREVGALADLQHPNIVRYYTAWLEDTAYRCDTASESDTTSDSGSSSSSEFLYIQMELCDKRTLKVWIDERNAHRKPKRREESLSITQQIVNGVEYIHSKKLLHRDLKPANIMFGMSDGEGKGEVKIGDFGLVTAEDNDNDENLLERTKKTGTVSYMAPEQRNQTSYDRKVDIFALGLIYFEPLWDLSGMEKAKVWNDVRSQRFPQQFNSQFTLENKVIESLLCANPEERPDARQLKTKLNECSRVLTRVHNIHQDNRTI,negative +AAGACCACACACACAGAAACAGGGAACAGCGUUCAA,MASTSRLDALPRVTCPNHPDAILVEDYRAGDMICPECDRVIDVGSEWRTFSNDKATKDPSRVGDSQNPLLSDGDLSTMIGKGTGAASFDEFGNSKYQNRRTMSSSDRAMMNAFKEITTMADRINLPRNIVDRTNNLFKQVYEQKSLKGRANDAIASACLYIACRQEGVPRTFKEICAVSRISKKEIGRCFKLILKALETSVDLITTGDFMSRFCSNLCLPKQVQMAATHIA,negative +AGCGCGCACCTACTGTGATGCAGAAGTCACAGCAAGGCCC,PHITDVVLDKANKTPLRQLDPSRLPDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFAKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRQSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPINRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDTASEATRPATLNRFSALQQTLPAENTDNRRVVQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRTRTPATKRSFSKEVEERSRERPSQPEGLRKAASLTEDRGRDPVKREATLPPVSPPKAALSVDEVEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRLGIESTLERSTIAREHMGRLLHQLLCAGHLSTAQYYQGLYETLELAEDMEIDIPHVWLYLAELITPILQEDGVPMGELFREITKPLRPMGKATSLLLEILGLLCKSMGPKKVGMLWREAGLSWREFLAEGQDVGSFVAEKKVEYTLGEESEAPGQRTLAFEELRRQLEKLLKDGGSNQRVFDWIDANLNEQQIASNTLVRALMTTVCYSAIIFETPLRVDVQVLKVRARLLQKYLCDEQKELQALYALQALVVTLEQPANLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFNWLREAEDEESDHN,negative +GGGAGAAGGGAAGTAACAGGCUAGAAGUUUAGACCAAGGGGCGGGAUGAGTGAGAAGAGGTGACGGTACCAG,MKKRKVLIPLMALSTILVSSTGNLEVIQAEVKQENRLLNESESSSQGLLGYYFSDLNFQAPMVVTSSTTGDLSIPSSELENIPSENQYFQSAIWSGFIKVKKSDEYTFATSADNHVTMWVDDQEVINKASNSNKIRLEKGRLYQIKIQYQRENPTEKGLDFKLYWTDSQNKKEVISSDNLQLPELKQKSSNSRKKRSTSAGPTVPDRDNDGIPDSLEVEGYTVDVKNKRTFLSPWISNIHEKKGLTKYKSSPEKWSTASDPYSDFEKVTGRIDKNVSPEARHPLVAAYPIVHVDMENIILSKNEDQSTQNTDSQTRTISKNTSTSRTHTSEVHGNAEVHASFFDIGGSVSAGFSNSNSSTVAIDHSLSLAGERTWAETMGLNTADTARLNANIRYVNTGTAPIYNVLPTTSLVLGKNQTLATIKAKENQLSQILAPNNYYPSKNLAPIALNAQDDFSSTPITMNYNQFLELEKTKQLRLDTDQVYGNIATYNFENGRVRVDTGSNWSEVLPQIQETTARIIFNGKDLNLVERRIAAVNPSDPLETTKPDMTLKEALKIAFGFNEPNGNLQYQGKDITEFDFNFDQQTSQNIKNQLAELNATNIYTVLDKIKLNAKMNILIRDKRFHYDRNNIAVGADESVVKEAHREVINSSTEGLLLNIDKDIRKILSGYIVEIEDTEGLKEVINDRYDMLNISSLRQDGKTFIDFKKYNDKLPLYISNPNYKVNVYAVTKENTIINPSENGDTSTNGIKKILIFSKKGYEIG,negative +CTTCTGCCCGCCTCCTTCCAACGGGTACTGCCTATCAGACATGGAAACGGTGCCGTTGGGAGACGAGATAGGCGGACACT,MIPPPRRSASSTPKDYRSSRDLQPWRGVSSGDAAETSQQSRHRRDAIADGGGRLKGAAQSSPSSGTRRSGPYAQGRAMPKNENIPKPGKQRLGPRKKKLSTLKKKILLDRLERWRDKQHEGALSTPSATASSEEAKCNNPFPLCPPGELSPPPSPPATICPAVVDKSTSYGQVGGANGERSVWAITIYNLVDQEDVEDDDDHAEIERDLWDMSSAFGVVRSVQVPRGTAVQVSDAEVSAAAAAGEPAAVAAKVAFATNAEAECARDGLNGRIVGGKPLLVRIHRCDGHFCGGVCPGDPDGSGLWRVAIENLIDEEDDLDDEDEYAEISANVSAMMGCYGKLVDVQVRRSSPSKGEVQEDVATRAATTAGATQAVVVTFGSLAEAEACVQGIKGCRVGGKELDAHVVLDSERVLPSNPAFKCDQEHAHSSDVAAAVAGQGDSMMKQEAGTEPSPCVDQDTAAAVASSTEWRVVIRGLIDEDDLQDDDDDYAEVCSDVTALVSSYGAVVGLDIPRGRETGSCCYGAEPGEAVVVFRSLQEAEACARGLSGRKVAGNILDAQVLTQPAPSQQGPLQGGASGTGPPVANRERKPAKECPLPQHQASSHQSCGKVPELDGSGPGMLRGFGNRVEDCCGRPKIACTDSDEPQAIAAAAPPGQSIEGPKTTALAKAGKRIQTKYQEAAALPKPPGVRGGLPNAYVNQPPDKEVNDLVFEMLQLLFKFQERARLSDPSKAKTRRRLVIGLREVLRGVKAKKVRLLIVAPNVDAVGGEGGLDDKVVEIIDKAREAEYPVVFALSKRKIGKALGKTIKVSAVGVYSFDGANEQQKQLKRRMETISSLPSPSPRQSDPPTDDALASPPSSSACGDSQDPAGKGSRV,negative +GAUGUUUCGAAUGUUGCGGGUGAGACACAGCAUGACAAACUACCGUGUCA,MTVFLSFAFLAAILTHIGCSNQRRSPENSGRRYNRIQHGQCAYTFILPEHDGNCRESTTDQYNTNALQRDAPHVEPDFSSQKLQHLEHVMENYTQWLQKLENYIVENMKSEMAQIQQNAVQNHTATMLEIGTSLLSQTAEQTRKLTDVETQVLNQTSRLEIQLLENSLSTYKLEKQLLQQTNEILKIHEKNSLLEHKILEMEGKHKEELDTLKEEKENLQGLVTRQTYIIQELEKQLNRATTNNSVLQKQQLELMDTVHNLVNLCTKEGVLLKGGKREEEKPFRDCADVYQAGFNKSGIYTIYINNMPEPKKVFCNMDVNGGGWTVIQHREDGSLDFQRGWKEYKMGFGNPSGEYWLGNEFIFAITSQRQYMLRIELMDWEGNRAYSQYDRFHIGNEKQNYRLYLKGHTGTAGKQSSLILHGADFSTKDADNDNCMCKCALMLTGGWWFDACGPSNLNGMFYTAGQNHGKLNGIKWHYFKGPSYSLRSTTMMIRPLDF,negative +UAAGCUCUUUGGCUUAGCCCGACACGUUGAACUCCAGAGU,MKEFEVKVASTAFVLVLFSLTINQILASETSTKFRSPVPAPTVPDWNHLPNEGNEENVVSAPKQDGASGGQKPYWTKREKMMKRLHAEPAGNTVRFRCAVDGNPKPQVLWYKNDLIVQKNDRVGGYKYRNQVLILESVVLSDKGNYMCVARNEYGSINHTYQLDVQERSASKPILAEGLPQNKSAYIGDDVTFKCKVYSDAHPHIQWLKSINNHNNAAPNYTVLKAAGVNTTDLDMEVLILKNVSFEEAGEYTCLAGNSIGISHQSAWLSVLPVPPPTTDTITKGIPNETNIIIYVMCGVLVILFGLAVVLVLYYHCYNGKDPPMLVRIENPDNIPPMTKIEHPTMLFGNTQAWQRMCMPMQEPFEFNIQLDLQWELQREDITLVERLDEGFFGQVFKADLVTCNNTRKEKMVCAVKMLKGNRNEKDVLDLLTEMDQMKRVGKHKNIINLLGVCTQNGPLWLVIEYAAQGNLRDYLRRNRPQNTLCNLVLPSEGRNPDDELPVPHGDTLTQKDIVSFAFQVARGLEFLAQKKCIHRDLAARNVLVTEELVMKIADFGLARDIRSCDYYRKHTRGHLPYKWMALEAMSDNIFTHATDVWSFGVLLWEIFSLAGSPYPGIKTHELVKFLRSGERLDKPQYASQEMYRLMRDCWEEDPSKRPNFRTLVEDLDRMLAESSTEVYIDFAAGCEAEYSESSEDESESQNSDEEDDDSVFERMRQIDSLSNGNIPFNEEDSSNSDPYVAPLLQNEENVLQNEHARLRSEA,negative +GGGAGAGCGAAGCGUGCUGGGCUGCUAUUUUGGCGUAAGCUGGUUUUUGGUGGUUGCGUUUUGAUCAUAACCCAGAGGUCGAUGGAUCC,MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPGPHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR,negative +BAGCGCCGGTGGTGGTGGGGGTTGTTGTTACGCGGTATTAT,MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINYDEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQAVAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQGIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADMDFSALLSQISS,negative +GGGAGGACGATGCGGCATGCGTCTGACCTACGTGCCAAGCATTTGTGTAACCCGTCAGACGACTCGCCCGA,VFTDNSSPPAVPQSFQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGFGAYMSKAHGVDPNIRTGVRTITTGSPITYSTYGKFLADGGCSGGAYDIIICDECHSTDATSILGIGTVLDQAETAGARLVVLATATPPGSVTVSHPNIEEVALSTTGEIPFYGKAIPLEVIKGGRHLIFCHSKKKCDELAAKLVALGINAVAYYRGLDVSVIPTSGDVVVVSTDALMTGFTGDFDSVIDCNTCVTQTVDFSLDPTFTIETTTLPQDAVSRTQRRGRTGRGKPGIYRFVAPGERPSGMFDSSVLCECYDAGCAWYELTPAETTVRLRAYMNTPGLPVCQDHLEFWEGVFTGLTHIDAHFLSQTKQSGENFPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPTLHGPTPLLYRLGAVQNEVT,negative +AACUAGCAGGCAGAGAAGAGUGGGUGCGACCACAGGAUGUUAUGGCCUG,PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGKISKIGPENPYNTPVFAIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDESFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPXRXKNPEMVIYQYMDDLYVGSDLEIGQHRAKIEELRSHLLSWGFTTPDKKHQKEPPFLWMGYELHPDSWTVQPIELPEKDSWTVNE,negative +GUUCCAGGCGCGUUAGCAAAACCGCGGAUC,MAMQMQLEANADTSVEEESFGPQPISRLEQCGINANDVKKLEEAGFHTVEAVAYAPKKELINIKGISEAKADKILAEAAKLVPMGFTTATEFHQRRSEIIQITTGSKELDKLLQGGIETGSITEMFGEFRTGKTQICHTLAVTCQLPIDRGGGEGKAMYIDTEGTFRPERLLAVAERYGLSGSDVLDNVAYARAFNTDHQTQLLYQASAMMVESRYALLIVDSATALYRTDYSGRGELSARQMHLARFLRMLLRLADEFGVAVVITNQVVAQVDGAAMFAADPKKPIGGNIIAHASTTRLYLRKGRGETRICKIYDSPCLPEAEAMFAINADGVGDAKD,negative +CCGCGCAAGGGGUAACCGGAGAAUAUUUGG,IMEIRTVAVGIVAIKGVESEYYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHSGGEMFVALNQKGLPVKGKKTKKEQKTAHFLPMAIT,negative +CCCUGAUGGUAGACGCCGGGGUGCCGGAA,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,negative +GGGACACAAUGGACGCACCUCCGACGCACAGUCGCAGGCUCGAAAGAGACUAAAUGCUAACGGCCGACAUGAGAG,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,negative +GACGAGGCUAAAACAAUUGUGUUCCAGGAUUGCGGUACAGGCACCGCUGGGAGUACUACAAGCUUCUGGACUCGGU,GLVKKAHEISVLCDAELALIIFSPKGKLYEYATDSKMEIILERYERYTYAEKALIASDPDVQGNWCHEYIKLKAKFEALNKSQRHLMGEQLDTLNQKELLQLETKLEGSLKNVRSRKTQLMLDSISELQEKGKSLQEQNTCLEKEILGKQKDKAPKQHVQWEKQNQPPPTSSAPMPFLIGDIHPTPNIRNFQGRTVADA,negative +GGGAGAGGAGAGAACGUUCUACAGCGCCGGUGGGUGGGCAUAGGGUGGAUGCGCUGUCGAUCGAUCGAUCGAUG,GRQVDIDGEDYQRRDSIAQLLEDWGLIVIEDSAREDLFGLTNNFRVISFKQKDDWTLKAKYTIGN,negative +GUAAACCGAAGUACUAGACUUGACCUAACA,MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYTFLLPEMDNCRSSSSPYVSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQDNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVLVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF,negative +CACCUACCUAAUUAUUAAACUUUGGGCAGUAUCCCGCUUUGCUUCUUAUC,MIPPPRRSASSTPKDYRSSRDLQPWRGVSSGDAAETSQQSRHRRDAIADGGGRLKGAAQSSPSSGTRRSGPYAQGRAMPKNENIPKPGKQRLGPRKKKLSTLKKKILLDRLERWRDKQHEGALSTPSATASSEEAKCNNPFPLCPPGELSPPPSPPATICPAVVDKSTSYGQVGGANGERSVWAITIYNLVDQEDVEDDDDHAEIERDLWDMSSAFGVVRSVQVPRGTAVQVSDAEVSAAAAAGEPAAVAAKVAFATNAEAECARDGLNGRIVGGKPLLVRIHRCDGHFCGGVCPGDPDGSGLWRVAIENLIDEEDDLDDEDEYAEISANVSAMMGCYGKLVDVQVRRSSPSKGEVQEDVATRAATTAGATQAVVVTFGSLAEAEACVQGIKGCRVGGKELDAHVVLDSERVLPSNPAFKCDQEHAHSSDVAAAVAGQGDSMMKQEAGTEPSPCVDQDTAAAVASSTEWRVVIRGLIDEDDLQDDDDDYAEVCSDVTALVSSYGAVVGLDIPRGRETGSCCYGAEPGEAVVVFRSLQEAEACARGLSGRKVAGNILDAQVLTQPAPSQQGPLQGGASGTGPPVANRERKPAKECPLPQHQASSHQSCGKVPELDGSGPGMLRGFGNRVEDCCGRPKIACTDSDEPQAIAAAAPPGQSIEGPKTTALAKAGKRIQTKYQEAAALPKPPGVRGGLPNAYVNQPPDKEVNDLVFEMLQLLFKFQERARLSDPSKAKTRRRLVIGLREVLRGVKAKKVRLLIVAPNVDAVGGEGGLDDKVVEIIDKAREAEYPVVFALSKRKIGKALGKTIKVSAVGVYSFDGANEQQKQLKRRMETISSLPSPSPRQSDPPTDDALASPPSSSACGDSQDPAGKGSRV,negative +GAGGCUGAUGGCAGACGCCGGCCGAAGACA,MEKVQYLTRSAIRRASTIEMPQQARQKLQNLFINFCLILICLLLICIIVMLL,negative +GAUGUUUCGAAUGUUGCGGGUGAGACACAGCAUGACAAACUACCGUGUCA,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +CTCCTCTGACTGTAACCACGAGTTACTCTGCAAGAAGTTGTCAAGAGCGTGGGAGGGCGGGCATAGGTAGTCCAGAAGCC,MDKLVVNYYEYKHPIINKDLAIGAHGGKKFPTLGAWYDVINEYEFQTRCPIILKNSHRNKHFTFACHLKNCPFKVLLSYAGNAASSETSSPSANNNTNPPGTPDHIHHHSNNMNNEDNDNNNGSNNKVSNDSKLDFVTDDLEYHLANTHPDDTNDKVESRSNEVNGNNDDDADANNIFKQQGVTIKNDTEDDSINKASIDRGLDDESGPTHGNDSGNHRHNEEDDVHTQMTKNYSDVVNDEDINVAIANAVANVDSQSNNKHDGKDDDATNNNDGQDNNTNNDHNNNSNINNNNVGSHGISSHSPSSIRDTSMNLDVFNSATDDIPGPFVVTKIEPYHSHPLEDNLSLGKFILTKIPKILQNDLKFDQILESSYNNSNHTVSKFKVSHYVEESGLLDILMQRYGLTAEDFEKRLLSQIARRITTYKARFVLKKKKMGEYNDLQPSSSSNNNNNNDGELSGTNLRSNSIDYAKHQEISSAGTSSNTTKNVNNNKNDSNDDNNGNNNNDASNLMESVLDKTSSHRYQPKKMPSVNKWSKPDQITHSDVSMVGLDESNDGGNENVHPTLAEVDAQEARETAQLAIDKINSYKRSIDDKNGDGHNNSSRNVVDENLINDMDSEDAHKSKRQHLSDITLEERNEDDKLPHEVAEQLRLLSSHLKEVENLHQNNDDDVDDVMVDVDVESQYNKNTTHHNNHHSQPHHDEEDVAGLIGKADDEEDLSDENIQPELRGQ,negative +ACUGUCCUCCCUUCAGAGAGCGCGGGACCCUUAACUUGGGGCCCACGAACAGCUUCAGUUCCGUCUCGGCGU,MPSKKNGRSGPQPHKRWVFTLNNPSEDERKKIRELPISLFDYFIVGEEGNEEGRTPHLQGFANFVKKQTFNKVKWYLGARCHIEKAKGTDQQNKEYCSKEGNLLMECGAPRSQGQRSDLSTAVSTLLESGSLVTVAEQHPVTFVRNFRGLAELLKVSGKMQKRDWKTNVHVIVGPPGCGKSKWAANFADPETTYWKPPRNKWWDGYHGEEVVVIDDFYGWLPWDDLLRLCDRYPLTVETKGGTVPFLARSILITSNQTPLEWYSSAAVPAVEALYRRITSLVFWKNATEQSTEEGGQFVTLSPPCPEFPYEINY,negative +GUAGUCAAAAGUCAUACAGCUCUACCAACAGCUCGA,MRKIVVAAIAVSLTTVSITASASADPSKDSKAQVSAAEAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKVKPSAASIDAAKKAGVNNGNPLDAVQQ,negative +AATACGACTCACTATAGAGGGAGGACGATGCGGGGTGCTTCGAGCGTAGGAAGAAAGCCGGGGGCTGCAGATAATGTATAGCCAGACGACGGA,MEDDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKEEIAEVANEIESLGSTEERKNMQRNKQVAMGRKKFNMDPKKGIQFLIENGLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERDEFSIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNTGVFQSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIKNEPFKIPVWFFLQNLYESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEDWIKCIKAAISRDPFYEMLAARKKKVSSTKRH,negative +CATGCGCCTTCCCCCTGTGGTTGGTGTCAGCCGGCCTGTG,MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP,negative +AGAAAAAAACAAUCCACAGAACAGCGCGUG,MGCRRTREGPSKAMIFPWKCQSTQRDLWNIFKLWGWTMLCCDFLAHHGTDCWTYHYSEKPMNWQRARRFCRDNYTDLVAIQNKAEIEYLEKTLPFSRSYYWIGIRKIGGIWTWVGTNKSLTEEAENWGDGEPNNKKNKEDCVEIYIKRNKDAGKWNDDACHKLKAALCYTASCQPWSCSGHGECVEIINNYTCNCDVGYYGPQCQFVIQCEPLEAPELGTMDCTHPLGNFSFSSQCAFSCSEGTNLTGIEETTCGPFGNWSSPEPTCQVIQCEPLSAPDLGIMNCSHPLASFSFTSACTFICSEGTELIGKKKTICESSGIWSNPSPICQKLDKSFSMIKEGDYNPLFIPVAVMVTAFSGLAFIIWLARRLKKGM,negative +TGTATCGTATTTGGTGATGTTTGGTGTTCA,MPSKKNGRSGPQPHKRWVFTLNNPSEDERKKIRELPISLFDYFIVGEEGNEEGRTPHLQGFANFVKKQTFNKVKWYLGARCHIEKAKGTDQQNKEYCSKEGNLLMECGAPRSQGQRSDLSTAVSTLLESGSLVTVAEQHPVTFVRNFRGLAELLKVSGKMQKRDWKTNVHVIVGPPGCGKSKWAANFADPETTYWKPPRNKWWDGYHGEEVVVIDDFYGWLPWDDLLRLCDRYPLTVETKGGTVPFLARSILITSNQTPLEWYSSAAVPAVEALYRRITSLVFWKNATEQSTEEGGQFVTLSPPCPEFPYEINY,negative +GGATGGGTGGGTGGGGAGGTTGTAGACTGTAT,MASNFTQFVLVDNGGTGDVTVAPSNFANGVAEWISSNSRSQAYKVTCSVRQSSAQNRKYTIKVEVPKVATQTVGGVELPVAAWRSYLNMELTIPIFATNSDCELIVKAMQGLLKDGNPIPSAIAANSGIY,negative +AGCAGCACAGAGGTCAGATGGTTACTGCGGGGTATGGGGACTGGTTGCGTGGCTTGGTGTCCTATGCGTGCTACCGTGAA,AKVLVVLLLFAGVDAETHVTGGSAAHAASTFAGLFSPGAKQDIQLINTNGSWHINRTA,negative +CAGCTCAGAAGCTTGATCCTGTGAGCGAAAATCCGGAGTAGAGGAGCAGCTGGGTGCTGACTCGAAGTCGTGCATCTGCA,MPFVNKQFNYKDPVNGVDIAYIKIPNVGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAGHRLYGIAINPNRVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNRKTYLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLKNFTGLFEFYKLLCVRGIITSKTKSLDKGYNKALNDLCIKVNNWDLFFSPSEDNFTNDLNKGEEITSDTNIEAAEENISLDLIQQYYLTFNFDNEPENISIENLSSDIIGQLELMPNIERFPNGKKYELDKYTMFHYLRAQEFEHGKSRIALTNSVNEALLNPSRVYTFFSSDYVKKVNKATEAAMFLGWVEQLVYDFTDETSEVSTTDKIADITIIIPYIGPALNIGNMLYKDDFVGALIFSGAVILLEFIPEIAIPVLGTFALVSYIANKVLTVQTIDNALSKRNEKWDEVYKYIVTNWLAKVNTQIDLIRKKMKEALENQAEATKAIINYQYNQYTEEEKNNINFNIDDLSSKLNESINKAMININKFLNQCSVSYLMNSMIPYGVKRLEDFDASLKDALLKYIYDNRGTLIGQVDRLKDKVNNTLSTDIPFQLSKYVDNQRLLSTFTEYIKNIINTSILNLRYESNHLIDLSRYASKINIGSKVNFDPIDKNQIQLFNLESSKIEVILKNAIVYNSMYENFSTSFWIRIPKYFNSISLNNEYTIINCMENNSGWKVSLNYGEIIWTLQDTQEIKQRVVFKYSQMINISDYINRWIFVTITNNRLNNSKIYINGRLIDQKPISNLGNIHASNNIMFKLDGCRDTHRYIWIKYFNLFDKELNEKEIKDLYDNQSNSGILKDFWGDYLQYDKPYYMLNLYDPNKYVDVNNVGIRGYMYLKGPRGSVMTTNIYLNSSLYRGTKFIIKKYASGNKDNIVRNNDRVYINVVVKNKEYRLATNASQAGVEKILSALEIPDVGNLSQVVVMKSKNDQGITNKCKMNLQDNNGNDIGFIGFHQFNNIAKLVASNWYNRQIERSSRTLGCSWEFIPVDDGWGERPL,negative +CAAGGCAGAAUGUAAUGCUGAAUAAGAGAGAAAAGUGUUGGUGAG,MSMSPKHTTPFSVSDILSPLEESYKKVGMEGGGLGAPLAAYRQGQAAPPAAAMQQHAVGHHGAVTAAYHMTAAGVPQLSHSAVGGYCNGNLGNMSELPPYQDTMRNSASGPGWYGANPDPRFPAISRFMGPASGMNMSGMGGLGSLGDVSKNMAPLPSAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGGGGGGGAGCPQQQQAQQQSPRRVAVPVLVKDGKPCQAGAPAPGAGSLQGHAQQQAQQQAQAAQAAAAAISVGSGGPGLGAHPGHQPGSAGQSPDLAHHAASPAALQGQVSSLSHLNSSGSDYGTMSCSTLLYGRTW,negative +CAGCTCAGAAGCTTGATCCTGTGCGGGGCAAAGAGGTCCGAATTTGAAGGCTCCCCTGGACTCGAAGTCGTGCATCTGCA,MAIPKELLVLLLGIAILSKVAECAAFGSRRGLVETVFDVTRFGARPNTPADSTRGLMMAWRSACQSPGPAKVVIPPGTYTTGETIFQGPCTSPRPITIEIQGTLLSNTDMSLYTRAAWISIEHVDGIVITGGGTLNGQGKSSWQFADKSGSTPPLPSSLVFQTVRSSSIKNLNFVDAKGVHLKITDSSDISVSNIKITAPGDSPNTDGLHISDTINVNVTDSTIGTGDDCISIGDGNSNVYISNINCGPGHGISIGSLGKRLDETDVKGVTVRNCTFRGTTNGARIKTYMGSPSLQVSGVVYEDIILDNVKNPIVIDQHYHSKNRNEPSRVKLVDIHFRNIRGTTTSKIPVLLNCSEALPCEGVELVDIDLAPVGSIGPLLPATCQNAKTILNGKNNPPAC,negative +GGGAGCTCAGAATAAACGCTCAAGGTGGTGGGCGGGGTGTAGAATTGGAAGGGATTCGACATGAGGCCCGGATC,ASFTCLAIWALASAGVVPLVLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAAFFFVPVIISTVCYVSIIRCLSSSAVANRSKK,negative +TCCCACGCATTCTCCACATCGATACTGAGCATCGTACATGATCCCGCAACGGGCAGTATTCCTTTCTGTCCTTCCGTCAC,MKKTLIALAIAASAASGMAHAWMTGDFNGSVDIGGSITADDYRQKWEWKVGTGLNGFGNVLNDLTNGGTKLTITVTGNKPILLGRTKEAFATPVTGGVDGIPHIAFTDYEGASVVLRNPDGETNKKGLAYFVLPMKNAEGTKVGSVKVNASYAGVLGRGGVTSADGELLSLFADGLSSIFYGGLPRGSELSAGSAAAARTKLFGSLSRNDILGQIQRVNANITSLVDVAGSYRENMEYTDGTVVSAAYALGIANGQTIEATFNQAVTTSTQWSAPLNVAITYY,negative +GGGAGGACGATGCGGGCGAAGGCACACCGAGTTCATAGTATCCCACAGACGACGAGCGGGA,MSARGEEAAGEASGSQEQPEPALAEPKKRGPGRPRKPQQEPTGEPVPKRPRGRPKGSKNKGPSKAAQKKAETTGEKRPRGRPRKWPQQVVQEKPAQEEEEEEEEEEAEED,negative +GCGCAAACCCGAAGAAUGCCCAAAUUGAUCCAGAGCAAGUGGGAAUGAUAUAAAGUACCUGGUCCUGG,MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYTFLLPEMDNCRSSSSPYVSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQDNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVLVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF,negative +CAAAACGTGGATTGGGTCAAATGAGTCGTTTTTC,MLDLFADAEPWQEPLAAGAVILRRFAFNAAEQLIRDINDVASQSPFRQMVTPGGYTMSVAMTNCGHLGWTTHRQGYLYSPIDPQTNKPWPAMPQSFHNLCQRAATAAGYPDFQPDACLINRYAPGAKLSLHQDKDEPDLRAPIVSVSLGLPAIFQFGGLKRNDPLKRLLLEHGDVVVWGGESRLFYHGIQPLKAGFHPLTIDCRYNLTFRQAGKKE,negative +GGAGGCGCGATGTAGGTATGTGAGGGCGGCGCGGTGGGCG,MPSNQEARLFLAVLVLAQVLPILVDSAAEKGFKQAFWQPLCQVSEELDDQPKGALFTLQAAASKIQKMRDAALRASIYAEINHGTNRAKAAVIVANHYAMKADSGLEALKQTLSSQEVTATATASYLKGRIDEYLNLLLQTKESGTSGCMMDTSGTNTVTKAGGTIGGVPCKLQLSPIQPKRPAATYLGKAGYVGLTRQADAANNFHDNDAECRLASGHNTNGLGKSGQLSAAVTMAAGYVTVANSQTAVTVQALDALQEASGAAHQPWIDAWKAKKALTGAETAEFRNETAGIAGKTGVTKLVEEALLKKKDSEASEIQTELKKYFSGHENEQWTAIEKLISEQPVAQNLVGDNQPTKLGELEGNAKLTTILAYYRMETAGKFEVLTQKHKPAESQQQAAETEGSCNKKDQNECKSPCKWHNDAENKKCTLDKEEAKKVADETAKDGKTGNTNTTGSSNSFVISKTPLWLAVLLF,negative +GGGACACAAUGGACGACUCACUAUUUGUUUUCGCGCCCAGUUGCAAAAAGUGUCGUAACGGCCGACAUGAGAG,MAPFLRIAFNSYELGSLQAEDEANQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKSTFDAHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNGKAEFWLDLQPQAKVLMSVQYFLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQVTQRASRRSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTYGKIWEGSSKCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGVTGNIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKNLIDSMDQSAFAGFSFVNPKFEHLLED,negative +GTAGATTGAATTAATTGGAAGAGTCGATCAGTGTTTAATG,MAITKINDCFELLSMVTYADKLKSLIKKEFSISFEEFAVLTYISENKEKEYYLKDIINHLNYKQPQVVKAVKILSQEDYFDKKRNEHDERTVLILVNAQQRKKIESLLSRVNKRITEANNEIEL,negative +CGGAATTCCGAGCGTGGGCGTGAGCCCTAAACACAAGTCCGCAGGGGTGTGGTAATATTCGCAGTTGTGTGTACGCCCACGCTCGAG,MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP,negative +UCACCUGUACACUACCUCUACCAUGCUUGAGCCUACGCCGCCGACACCC,ASFTCLAIWALASAGVVPLVLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAAFFFVPVIISTVCYVSIIRCLSSSAVANRSKK,negative +TACCAAGATCCCACAACTAGCCGACCACAATTGCCGGCCA,MGLLGILCFLIFLGKTWGQEQTYVISAPKIFRVGASENIVIQVYGYTEAFDATISIKSYPDKKFSYSSGHVHLSSENKFQNSAILTIQPKQLPGGQNPVSYVYLEVVSKHFSKSKRMPITYDNGFLFIHTDKPVYTPDQSVKVRVYSLNDDLKPAKRETVLTFIDPEGSEVDMVEEIDHIGIISFPDFKIPSNPRYGMWTIKAKYKEDFSTTGTAYFEVKEYVLPHFSVSIEPEYNFIGYKNFKNFEITIKARYFYNKVVTEADVYITFGIREDLKDDQKEMMQTAMQNTMLINGIAQVTFDSETAVKELSYYSLEDLNNKYLYIAVTVIESTGGFSEEAEIPGIKYVLSPYKLNLVATPLFLKPGIPYPIKVQVKDSLDQLVGGVPVTLNAQTIDVNQETSDLDPSKSVTRVDDGVASFVLNLPSGVTVLEFNVKTDAPDLPEENQAREGYRAIAYSSLSQSYLYIDWTDNHKALLVGEHLNIIVTPKSPYIDKITHYNYLILSKGKIIHFGTREKFSDASYQSINIPVTQNMVPSSRLLVYYIVTGEQTAELVSDSVWLNIEEKCGNQLQVHLSPDADAYSPGQTVSLNMATGMDSWVALAAVDSAVYGVQRGAKKPLERVFQFLEKSDLGCGAGGGLNNANVFHLAGLTFLTNANADDSQENDEPCKEILRPRRTLQKKIEEIAAKYKHSVVKKCCYDGACVNNDETCEQRAARISLGPRCIKAFTECCVVASQLRANISHKDMQLGRLHMKTLLPVSKPEIRSYFPESWLWEVHLVPRRKQLQFALPDSLTTWEIQGVGISNTGICVADTVKAKVFKDVFLEMNIPYSVVRGEQIQLKGTVYNYRTSGMQFCVKMSAVEGICTSESPVIDHQGTKSSKCVRQKVEGSSSHLVTFTVLPLEIGLHNINFSLETWFGKEILVKTLRVVPEGVKRESYSGVTLDPRGIYGTISRRKEFPYRIPLDLVPKTEIKRILSVKGLLVGEILSAVLSQEGINILTHLPKGSAEAELMSVVPVFYVFHYLETGNHWNIFHSDPLIEKQKLKKKLKEGMLSIMSYRNADYSYSVWKGGSASTWLTAFALRVLGQVNKYVEQNQNSICNSLLWLVENYQLDNGSFKENSQYQPIKLQGTLPVEARENSLYLTAFTVIGIRKAFDICPLVKIDTALIKADNFLLENTLPAQSTFTLAISAYALSLGDKTHPQFRSIVSALKREALVKGNPPIYRFWKDNLQHKDSSVPNTGTARMVETTAYALLTSLNLKDINYVNPVIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVKQLRLSMDIDVSYKHKGALHNYKMTDKNFLGRPVEVLLNDDLIVSTGFGSGLATVHVTTVVHKTSTSEEVCSFYLKIDTQDIEASHYRGYGNSDYKRIVACASYKPSREESSSGSSHAVMDISLPTGISANEEDLKALVEGVDQLFTDYQIKDGHVILQLNSIPSSDFLCVRFRIFELFEVGFLSPATFTVYEYHRPDKQCTMFYSTSNIKIQKVCEGAACKCVEADCGQMQEELDLTISAETRKQTACKPEIAYAYKVSITSITVENVFVKYKATLLDIYKTGEAVAEKDSEITFIKKVTCTNAELVKGRQYLIMGKEALQIKYNFSFRYIYPLDSLTWIEYWPRDTTCSSCQAFLANLDEFAEDIFLNGC,negative +CCAAGCAUCAGCUGG,VVIRSNNFTDNAKTIIVQLNESIAINCTRPNNNTRKSIHIGPGRAFYTTGDIIGNIRQAHCNLSRTKWENTLKQIAKKLREQFGNKTIVFNH,negative +ACCUAGCGCGCUUGACGUGGCCCCUUCGCAGGUCCUGGAU,MLNQLDNLTERVRGSNKLVDRWLHVRKHLLVAYYNLVGIKPGKESYMRLNEKALDDFCQSLVDYLSAGHFSIYERILHKLEGNGQLARAAKIWPQLEANTQQIMDYYDSSLETAIDHDNYLEFQQVLSDIGEALEARFVLEDKLILLVLDAARVKHPA,negative +GGGAGCTCAGAATAAACGCTCAAGGAGGTGGGTGGGATGTAGACTGGAGAGGGATTCGACATGAGGCCCGGATC,MGVLLTQRTLLSLVLALLFPSMASMAAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQGLDVPKLREHCRERPGAFPSEETLRGLGRRGFLQTLNATLGCVLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILGLRNNIYCMAQLLDNSDTAEPTKAGRGASQPPTPTPASDAFQRKLEGCRFLHGYHRFMHSVGRVFSKWGESPNRSRRHSPHQALRKGVRRTRPSRKGKRLMTRGQLPR,negative +AUCGCCCUGAACCGGCCCAGCAGACUGCUGACGGAACGAC,ASFTCLAIWALASAGVVPLVLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAAFFFVPVIISTVCYVSIIRCLSSSAVANRSKK,negative +AGCAGCACAGAGGTCAGATGCGCGCAGAATTTTGAGTCATGTACTAAGGAATTGATTGGTCCTATGCGTGCTACCGTGAA,MLNQLDNLTERVRGSNKLVDRWLHVRKHLLVAYYNLVGIKPGKESYMRLNEKALDDFCQSLVDYLSAGHFSIYERILHKLEGNGQLARAAKIWPQLEANTQQIMDYYDSSLETAIDHDNYLEFQQVLSDIGEALEARFVLEDKLILLVLDAARVKHPA,negative +GGTTGGTGTGGTTGG,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,negative +GGGACGCGTGGTACCAAAGAGGCTGCGCGGAAGTGAGGGTGTTGGTTACGAAGGTTGGTGTGTGAAGCTT,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,negative +GACAGCGUGCCUAGAAGUCCAAGCUUAAAUAACCACGCUCGACAAGC,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,negative +CTTCTGCCCGCCTCCTTCCCTAGTGCAGGGGTTCACTCAGGACCTTACGAGCTTTTTCGGAGACGAGATAGGCGGACACT,MSSTESPVPAAAAPAEAVPASTPAPAAEQPAVGNGEQRNNADAANNTSLYVGELDPSVTEAMLFEIFSMIGTVASIRVCRDAVTRRSLGYAYVNFLNAADGERAMEQLNYSLIRNRPCRIMWSQRDPALRRTGQGNIFIKNLDAGIDNKALHDTFAAFGNILSCKVATNETGSLGYGFVHYETAEAAEAAIKHVNGMLLNDKKVYVGHHIPRKERQAKIEETRANFTNVYAKNVDPEVTDDEFEKLFTKFGKITSCVLQRDEDGKSKGFGFVNFEDHNEAQKAVDELHDSDFKGQKLFVARAQKKSEREEELRRSYEAAKNEKLAKFQGVNLYLKNIPESYDDERLREEFAPFGAITSCKIMRAPSGVSRGFGFVCYSAPEEANKAVSEMNGKMLDNRPLYVALAQRKDVRRQQLEAQIMQRNQLRLQQQAAAQGMGYPGPGMYYPQPGAFPGQPGGMVPRPRYAPAGMMPQGMPMAPYGQPGQFPAGMMPQGYRPARPPRGAPNAAGGPAPPAGARPPTGVNGAPRPAGQPVPGQPMPRGPAARPAGRPEADQPGALTAAALAKASPEEQKQMLGEAIYPKVAASQPELAGKLTGMILELPVTELLHLLEESEALDAKVNEALEVLKEYQQNDSAGAEAEANAEAPKTEA,negative +CCTTCGTTGTCTGCCTTCGTAGCGGATCGAATTACGCGTTAACGGCAACCGATAACGGGACCGATTGCACACCCTTCAGAATTCGCACCA,AKTALQVPLPHPMQMNALGGYSPASTCNGYGRMGLHQEKLPSDLDGMFIERLDCDMESIIRNDLMDGDTLDFNFDNVLPNQSFPHSVKTTTHSWVSG,negative +CCUGCCCUUUCCAACACCCGCCGAAACUCA,GRQVDIDGEDYQRRDSIAQLLEDWGLIVIEDSAREDLFGLTNNFRVISFKQKDDWTLKAKYTIGN,negative +GCCCGAUCUACUGCAUUACCGAAACGAUUUCCCCACUGU,QELLCAASLISDRWVLTAAHCLLYPPWDKNFTVNDILVRIGKYARSRYERNMEKISTLEKIIIHPGYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDKQIVTSLLQAGHKGRVTGWGNLKEMWTVNMNEVQPSVLQMVNLPLVERPICKASTGIRVTDNMFCAGYKPEEGKRGDACEGDSGGPFVMKNPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIRKMVDRFG,negative +CACGGTAGTGCTACCAGATGGTTATGTTACTTCAATTCTG,MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYTFLLPEMDNCRSSSSPYVSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQDNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVLVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF,negative +CTTCTGCCCGCCTCCTTCCCTAGTCACTATTGTCTGGCGTGGGTAGGTGCCAATGGTAGGAGACGAGATAGGCGGACACT,MKPGGNTIVIWMYAVATWLCFGSTSGWSFTLEDNNIFPKQYPIINFTTAGATVQSYTNFIRAVRGRLTTGADVRHEIPVLPNRVGLPINQRFILVELSNHAELSVTLALDVTNAYVVGYRAGNSAYFFHPDNQEDAEAITHLFTDVQNRYTFAFGGNYDRLEQLAGNLRENIELGNGPLEEAISALYYYSTGGTQLPTLARSFIICIQMISEAARFQYIEGEMRTRIRYNRRSAPDPSVITLENSWGRLSTAIQESNQGAFASPIQLQRRNGSKFSVYDVSILIPIIALMVYRCAPPPSSQFSLLIRPVVPNFNADVCMDPEPIVRIVGRNGLCVDVRDGRFHNGNAIQLWPCKSNTDANQLWTLKRDNTIRSNGKCLTTYGYSPGVYVMIYDCNTAATDATRWQIWDNGTIINPRSSLVLAATSGNSGTTLTVQTNIYAVSQGWLPTNNTQPFVTTIVGLYGLCLQANSGQVWIEDCSSEKAEQQWALYADGSIRPQQNRDNCLTSDSNIRETVVKILSCGPASSGQRWMFKNDGTILNLYSGLVLDVRASDPSLKQIILYPLHGDPNQIWLPLF,negative +AAGGACAGCACGAAUAAAACCUGCGUAAAUCCGCCCCAUUUGUGUAAGGGUAGUGGG,MDKLVVNYYEYKHPIINKDLAIGAHGGKKFPTLGAWYDVINEYEFQTRCPIILKNSHRNKHFTFACHLKNCPFKVLLSYAGNAASSETSSPSANNNTNPPGTPDHIHHHSNNMNNEDNDNNNGSNNKVSNDSKLDFVTDDLEYHLANTHPDDTNDKVESRSNEVNGNNDDDADANNIFKQQGVTIKNDTEDDSINKASIDRGLDDESGPTHGNDSGNHRHNEEDDVHTQMTKNYSDVVNDEDINVAIANAVANVDSQSNNKHDGKDDDATNNNDGQDNNTNNDHNNNSNINNNNVGSHGISSHSPSSIRDTSMNLDVFNSATDDIPGPFVVTKIEPYHSHPLEDNLSLGKFILTKIPKILQNDLKFDQILESSYNNSNHTVSKFKVSHYVEESGLLDILMQRYGLTAEDFEKRLLSQIARRITTYKARFVLKKKKMGEYNDLQPSSSSNNNNNNDGELSGTNLRSNSIDYAKHQEISSAGTSSNTTKNVNNNKNDSNDDNNGNNNNDASNLMESVLDKTSSHRYQPKKMPSVNKWSKPDQITHSDVSMVGLDESNDGGNENVHPTLAEVDAQEARETAQLAIDKINSYKRSIDDKNGDGHNNSSRNVVDENLINDMDSEDAHKSKRQHLSDITLEERNEDDKLPHEVAEQLRLLSSHLKEVENLHQNNDDDVDDVMVDVDVESQYNKNTTHHNNHHSQPHHDEEDVAGLIGKADDEEDLSDENIQPELRGQ,negative +GGGACGCGTGGTACCAAAGAGGCTGCGCGGAAGTGAGGGTGTTGGTTACGAAGGTTGGTGTGTGAAGCTT,MTPDIQAPFLSLLLLFPVLTVANVPTLTTSDSINPRRTTPVSTTQSSPTSSPTKETSWSTTTTLLTASSPAPSPAASPGHDGASTPTSSPAPSPAASPGHDGASTPTSSPAPSPAASPGHDGASTPTSSPAPSPAASPGHDGASTPTSSPAPSPAASPGHNGTSSPTGSPAPSPAASPGHDGASTPTSSPAPSPAASPGHNGTSSPTGSPAPSPAASPGHDGASTPTSSPAPSPAASPGHNGTSSPTGSPAPSPTASPGHDSAPSLTSSPAPSPTASPGQHGASSPTSSDTSSMTTRSMSSSMVTSAHKGTSSRATMTPVSKGTPSSVPSSETAPTAASHITRTAASSPSIALSTSSNPKTSQQLSVRVSLYFLSFRITNLQFNSSLENPQTSYYQELQRSIWGLILQIYKQRDFLGLSEIKFRPGSVVVELTLAFREGTTAEWVKAQFSQLEAHAASYNLTISGVSVYSAPFPSSAQAGSGVPGWGIALLVLVCVLVALAIIYLIALVVCQCGRKKCEQLDVFPTLDAYHPMSEYSTYHTHGRYVPPGSTKRSPYEEVSAGNGGSNLSYTNLAATSANL,negative +CTTCTGCCCGCCTCCTTCCCGGGTCATATGGGAACGCTACAGTGTTTCACGCTGAGTTGGAGACGAGATAGGCGGACACT,SRWDSTQQRAVLAAAVEIMVKFSSQPHLAQVVAEDLLSPSVMDVGDFKISITEGLPSGVPCTSQWNSIAHWLLTLCALSETTNLSPDIIQANSLFSFYG,negative +CGTACCAAGATCCCACAACTAGCCGACCAGGATTGCCGGC,MKRASAGGSRLLAWVLWLQAWQVAAPCPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDNPWVCDCRARPLWAWLQKFRGSSSEVPCSLPQRLAGRDLKRLAANDLQGCAVATGPYHPIWTGRATDEEPLGLPKCCQPDAADKASVLEPGRPASAGNALKGRVPPGDSPPGNGSGPRHINDSPFGTLPGSAEPPLTAVRPEGSEPPGFPTSGPRRRPGCSRKNRTRSHCRLGQAGSGGGGTGDSEGSGALPSLTCSLTPLGLALVLWTVLGPC,negative +CAGCGTCATTTAGGATTCGTCAGGTTCTACCGTAGTGTG,MDEVGAQVAAPMFIHQSLGRKRDLYYPMSNRLVQSQPQRRDEWNSKMWDWDSRRFEAKPVDVEVQEFDLTLRNRSGEERGLDLNLGSGLTAVEETTTTTQNVRPNKKVRSGSPGGNYPMCQVDNCTEDLSHAKDYHRRHKVCEVHSKATKALVGKQMQRFCQQCSRFHLLSEFDEGKRSCRRRLAGHNRRRRKTTQPEEVASGVVVPGNHDTTNNTANANMDLMALLTALACAQGKNAVKPPVGSPAVPDREQLLQILNKINALPLPMDLVSKLNNIGSLARKNMDHPTVNPQNDMNGASPSTMDLLAVLSTTLGSSSPDALAILSQGGFGNKDSEKTKLSSYENGVTTNLEKRTFGFSSVGGERSSSSNQSPSQDSDSRGQDTRSSLSLQLFTSSPEDESRPTVASSRKYYSSASSNPVEDRSPSSSPVMQELFPLQASPETMRSKNHKNSSPRTGCLPLELFGASNRGAADPNFKGFGQQSGYASSGSDYSPPSLNSDAQDRTGKIVFKLLDKDPSQLPGTLRSEIYNWLSNIPSEMESYIRPGCVVLSVYVAMSPAAWEQLEQKLLQRLGVLLQNSPSDFWRNARFIVNTGRQLASHKNGKVRCSKSWRTWNSPELISVSPVAVVAGEETSLVVRGRSLTNDGISIRCTHMGSYMAMEVTRAVCRQTIFDELNVNSFKVQNVHPGFLGRCFIEVENGFRGDSFPLIIANASICKELNRLGEEFHPKSQDMTEEQAQSSNRGPTSREEVLCFLNELGWLFQKNQTSELREQSDFSLARFKFLLVCSVERDYCALIRTLLDMLVERNLVNDELNREALDMLAEIQLLNRAVKRKSTKMVELLIHYLVNPLTLSSSRKFVFLPNITGPGGITPLHLAACTSGSDDMIDLLTNDPQEIGLSSWNTLRDATGQTPYSYAAIRNNHNYNSLVARKLADKRNKQVSLNIEHEVVDQTGLSKRLSLEMNKSSSSCASCATVALKYQRRVSGSQRLFPTPIIHSMLAVATVCVCVCVFMHAFPIVRQGSHFSWGGLDYGSI,negative +ACACGACGGGAATACTGACTCTCCCCCATGT,MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP,negative +GAGCCAGUAAGUGACCCGUACUAAUACUGUUGAGUAGUAUGUAGAGGAGUGGUGAUCCUCCAAACUGCUG,MAGPQALAFGLLLAVVTATLAAAQRDCVCDNYKLATSCSLNEYGECQCTSYGTQNTVICSKLASKCLAMKAEMTHSKSGRRIKPEGAIQNNDGLYDPDCDEQGLFKAKQCNGTATCWCVNTAGVRRTDKDTEITCSERVRTYWIIIELKHKERESPYDHQSLQTALQEAFTSRYKLNQKFIKNIMYENNVITIDLMQNSSQKTQDDVDIADVAYYFEKDVKGESLFHSSKSMDLRVNGEPLDLDPGQTLIYYVDEKAPEFSMQGLTAGIIAVIVVVSLAVIAGIVVLVISTRKKSAKYEKAEIKEMGEIHRELNA,negative +GGATGATGCCGCACTGACGCCACGTAGGTGGCGCACAGCC,PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKNSKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNRKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFYTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQK,negative +GAAGCUUUCACACAACAAGGCCCGGGACUGUAUUAGGGAAAUUAGAGUACAGACAGUCGCCGUGGGUCGAAUUCCGCUCA,MKKTLIALAIAASAASGMAHAWMTGDFNGSVDIGGSITADDYRQKWEWKVGTGLNGFGNVLNDLTNGGTKLTITVTGNKPILLGRTKEAFATPVTGGVDGIPHIAFTDYEGASVVLRNPDGETNKKGLAYFVLPMKNAEGTKVGSVKVNASYAGVLGRGGVTSADGELLSLFADGLSSIFYGGLPRGSELSAGSAAAARTKLFGSLSRNDILGQIQRVNANITSLVDVAGSYRENMEYTDGTVVSAAYALGIANGQTIEATFNQAVTTSTQWSAPLNVAITYY,negative +CCAGACGTGAGCACTAGATCAGTACGGAAG,MDHLNEATQGKEHSEMSNNVSDPKGPPAKIARLEQNGSPLGRGRLGSTGAKMQGVPLKHSGHLMKTNLRKGTMLPVFCVVEHYENAIEYDCKEEHAEFVLVRKDMLFNQLIEMALLSLGYSHSSAAQAKGLIQVGKWNPVPLSYVTDAPDATVADMLQDVYHVVTLKIQLHSCPKLEDLPPEQWSHTTVRNALKDLLKDMNQSSLAKECPLSQSMISSIVNSTYYANVSAAKCQEFGRWYKHFKKTKDMMVEMDSLSELSQQGANHVNFGQQPVPGNTAEQPPSPAQLSHGSQPSVRTPLPNLHPGLVSTPISPQLVNQQLVMAQLLNQQYAVNRLLAQQSLNQQYLNHPPPVSRSMNKPLEQQVSTNTEVSSEIYQWVRDELKRAGISQAVFARVAFNRTQGLLSEILRKEEDPKTASQSLLVNLRAMQNFLQLPEAERDRIYQDERERSLNAASAMGPAPLISTPPSRPPQVKTATIATERNGKPENNTMNINASIYDEIQQEMKRAKVSQALFAKVAATKSQGWLCELLRWKEDPSPENRTLWENLSMIRRFLSLPQPERDAIYEQESNAVHHHGDRPPHIIHVPAEQIQQQQQQQQQQQQQQQAPPPPQPQQQPQTGPRLPPRQPTVASPAESDEENRQKTRPRTKISVEALGILQSFIQDVGLYPDEEAIQTLSAQLDLPKYTIIKFFQNQRYYLKHHGKLKDNSGLEVDVAEYKEEELLKDLEESVQDKNTNTLFSVKLEEELSVEGNTDINTDLKD,negative +GGAGUCUUAGGCAGCGCGUUUUCGAGCUACUCCA,SHGGLPCQNSQRGKRSFPAVEICKYKGPARIVVSLVTNEDTPRPHAHSLVGKHCKDGLCTVQVGPNDMTASFPNLGILHVTRKDVVPTLKTRILAQHRLYKDLINNSGGEGQWMEPSDQEIEKKAKEMAKDMDLSVVRLCFQTYLPDVKGHFTQPLEPVISVPVFDSKAPNATTLKICRMDKSAGCCTGGEEVYLLCDKVQKEVIQVKFFEVST,negative +CTTCTGCCCGCCTCCTTCCGTTTGATCAAGCTGGTTTGGACTTTCGGAGACGAGATAGGCGGACACT,XQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGSTGSPGPGYGYSNYGFPPYGGITFHPGVTKSNAGVTHGTINTKFKNGPKDCAKSDDEESLTLPEKETEGEGPSLPMACTKTEPIALASTMEDKEQDMGFQDNLFLEKALQLARRHANALFDYAVTGDVKMLLAVQRHLTAVQDENGDSVLHLAIIHLHAQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRVGADLSLLDRWGNSVLHLAAKEGHDRILSILLKSRKAAPLIDHPNGEGLNAIHIAVMSNSLPCLLLLVAAGAEVNAQEQKSGRTALHLAVEYDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWEKAGEDEGVVPGTTPLDMAANWQVFDILNGKPYEPVFTSDDILPQGDMKQLTEDTRLQLCKLLEIPDPDKNWATLAQKLGLGILNNAFRLSPAPSKTLMDNYEMNSGIVTASVTVVWRHPSANSALQSLLLETAHCYL,negative +TTTTTGCTGATCTCGGGTTTGGACTCCTGTTTATTTATAA,IMEIRTVAVGIVAIKGVESEYYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHSGGEMFVALNQKGLPVKGKKTKKEQKTAHFLPMAIT,negative +TTGCACAAGATACGGCTACCTGTATGCGGCAATCGGCATTAAATCTATCTAAGCCAGCAGTAAC,QELLCAASLISDRWVLTAAHCLLYPPWDKNFTVNDILVRIGKYARSRYERNMEKISTLEKIIIHPGYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDKQIVTSLLQAGHKGRVTGWGNLKEMWTVNMNEVQPSVLQMVNLPLVERPICKASTGIRVTDNMFCAGYKPEEGKRGDACEGDSGGPFVMKNPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIRKMVDRFG,negative +TGGCTAGTGGGTAAGGGGCGGGAGGGTGACAGGGCGATCC,MAWYWWRRRRRRGWWKPRRRRWRRRRARRRGPARRHRARRRIVRHPCNGQTSSGNRVPRSVQAVDPKYVSLQLVWHSWDFRRGLFGQAGIKRMQQESDALTLSPVHRPKRPKRDTQVKEKTPEKDSDSAVQLRRLQPWIHSSQETKDEEEEIPEGPVQEQLLQQLQQQRLLRVQLESIAQEVLKIRRGHSLHPLLSSHA,negative +UCCAAACCCCGUUGAGAGUUGAUCCGGUCUAGGGAAUGGAAAGAAGUAGGUAUCGAAGAGAAUGUACCCU,MSMSPKHTTPFSVSDILSPLEESYKKVGMEGGGLGAPLAAYRQGQAAPPAAAMQQHAVGHHGAVTAAYHMTAAGVPQLSHSAVGGYCNGNLGNMSELPPYQDTMRNSASGPGWYGANPDPRFPAISRFMGPASGMNMSGMGGLGSLGDVSKNMAPLPSAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGGGGGGGAGCPQQQQAQQQSPRRVAVPVLVKDGKPCQAGAPAPGAGSLQGHAQQQAQQQAQAAQAAAAAISVGSGGPGLGAHPGHQPGSAGQSPDLAHHAASPAALQGQVSSLSHLNSSGSDYGTMSCSTLLYGRTW,negative +CAGCTCAGAAGCTTGATCCTGTGAGGAATGCTCATGCATAGCAAGGGCTAAACACGGCGACTCGAAGTCGTGCATCTGCA,IMEIRTVAVGIVAIKGVESEYYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHSGGEMFVALNQKGLPVKGKKTKKEQKTAHFLPMAIT,negative +GGATGATGCCGCACTGACGACACGTAGGTGGCGCACAGCC,MSSTESPVPAAAAPAEAVPASTPAPAAEQPAVGNGEQRNNADAANNTSLYVGELDPSVTEAMLFEIFSMIGTVASIRVCRDAVTRRSLGYAYVNFLNAADGERAMEQLNYSLIRNRPCRIMWSQRDPALRRTGQGNIFIKNLDAGIDNKALHDTFAAFGNILSCKVATNETGSLGYGFVHYETAEAAEAAIKHVNGMLLNDKKVYVGHHIPRKERQAKIEETRANFTNVYAKNVDPEVTDDEFEKLFTKFGKITSCVLQRDEDGKSKGFGFVNFEDHNEAQKAVDELHDSDFKGQKLFVARAQKKSEREEELRRSYEAAKNEKLAKFQGVNLYLKNIPESYDDERLREEFAPFGAITSCKIMRAPSGVSRGFGFVCYSAPEEANKAVSEMNGKMLDNRPLYVALAQRKDVRRQQLEAQIMQRNQLRLQQQAAAQGMGYPGPGMYYPQPGAFPGQPGGMVPRPRYAPAGMMPQGMPMAPYGQPGQFPAGMMPQGYRPARPPRGAPNAAGGPAPPAGARPPTGVNGAPRPAGQPVPGQPMPRGPAARPAGRPEADQPGALTAAALAKASPEEQKQMLGEAIYPKVAASQPELAGKLTGMILELPVTELLHLLEESEALDAKVNEALEVLKEYQQNDSAGAEAEANAEAPKTEA,negative +GAAGCUUACAAGAAGGACAGCACGAAUAAAACCUGCGUAAAUCCGCCCCAUUUGUGUAAAAAAAAAAAAAAAAAAAAAAAAA,AKVLVVLLLFAGVDAETHVTGGSAAHAASTFAGLFSPGAKQDIQLINTNGSWHINRTA,negative +CTTCTGCCCGCCTCCTTCCGATTGAAAGGTCTGTTTTTGGGGTTGGTTTGGGTCAATAGGAGACGAGATAGGCGGACACT,MAIPKELLVLLLGIAILSKVAECAAFGSRRGLVETVFDVTRFGARPNTPADSTRGLMMAWRSACQSPGPAKVVIPPGTYTTGETIFQGPCTSPRPITIEIQGTLLSNTDMSLYTRAAWISIEHVDGIVITGGGTLNGQGKSSWQFADKSGSTPPLPSSLVFQTVRSSSIKNLNFVDAKGVHLKITDSSDISVSNIKITAPGDSPNTDGLHISDTINVNVTDSTIGTGDDCISIGDGNSNVYISNINCGPGHGISIGSLGKRLDETDVKGVTVRNCTFRGTTNGARIKTYMGSPSLQVSGVVYEDIILDNVKNPIVIDQHYHSKNRNEPSRVKLVDIHFRNIRGTTTSKIPVLLNCSEALPCEGVELVDIDLAPVGSIGPLLPATCQNAKTILNGKNNPPAC,negative +CCTTCATCATTAACCCGTCCACGCGC,WPLTEEKIKALVEICXEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEEFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDXIIYQYMDDLYVGSDLEIGQHRTKVEELRQHLLXWGFTTPDKKHQKEPPFLWMGYELHP,negative +CTTCTGCCCGCCTCCTTCCGAGCATTCGTCAGATAGGTGGCAAACAGTTATGGGAACGGGAGACGAGATAGGCGGACACT,MKPGGNTIVIWMYAVATWLCFGSTSGWSFTLEDNNIFPKQYPIINFTTAGATVQSYTNFIRAVRGRLTTGADVRHEIPVLPNRVGLPINQRFILVELSNHAELSVTLALDVTNAYVVGYRAGNSAYFFHPDNQEDAEAITHLFTDVQNRYTFAFGGNYDRLEQLAGNLRENIELGNGPLEEAISALYYYSTGGTQLPTLARSFIICIQMISEAARFQYIEGEMRTRIRYNRRSAPDPSVITLENSWGRLSTAIQESNQGAFASPIQLQRRNGSKFSVYDVSILIPIIALMVYRCAPPPSSQFSLLIRPVVPNFNADVCMDPEPIVRIVGRNGLCVDVRDGRFHNGNAIQLWPCKSNTDANQLWTLKRDNTIRSNGKCLTTYGYSPGVYVMIYDCNTAATDATRWQIWDNGTIINPRSSLVLAATSGNSGTTLTVQTNIYAVSQGWLPTNNTQPFVTTIVGLYGLCLQANSGQVWIEDCSSEKAEQQWALYADGSIRPQQNRDNCLTSDSNIRETVVKILSCGPASSGQRWMFKNDGTILNLYSGLVLDVRASDPSLKQIILYPLHGDPNQIWLPLF,negative +TCCCCGGAACCTTTCCCTAGCCGAAACAGCCC,MSEAEARPTNFIRQIIDEDLASGKHTTVHTRFPPEPNGYLHIGHAKSICLNFGIAQDYKGQCNLRFDDTNPVKEDIEYVESIKNDVEWLGFHWSGNVRYSSDYFDQLHAYAIELINKGLAYVDELTPEQIREYRGTLTQPGKNSPYRDRSVEENLALFEKMRAGGFEEGKACLRAKIDMASPFIVMRDPVLYRIKFAEHHQTGNKWCIYPMYDFTHCISDALEGITHSLCTLEFQDNRRLYDWVLDNITIPVHPRQYEFSRLNLEYTVMSKRKLNLLVTDKHVEGWDDPRMPTISGLRRRGYTAASIREFCKRIGVTKQDNTIEMASLESCIREDLNENAPRAMAVIDPVKLVIENYQGEGEMVTMPNHPNKPEMGSRQVPFSGEIWIDRADFREEANKQYKRLVLGKEVRLRNAYVIKAERVEKDAEGNITTIFCTYDADTLSKDPADGRKVKGVIHWVSAAHALPVEIRLYDRLFSVPNPGAADDFLSVINPESLVIKQGFAEPSLKDAVAGKAFQFEREGYFCLDSRHSTAEKPVFNRTVGLRDTWAKVGE,negative +GAATTGCGACAGTCGGGACATGTCGCGAGG,MLSWGYFLFLLPTLPGAQSQVQLVESGGDVRKPGDSLRLSCKGSGFTFSNYWLGWVRQAPGKALNGSLPLTPLAAAPTYIPGVSGRFTISRDNARALLHLDMSDLRPEDTGRYHCER,negative +GGCGGCCGTGAAATTTGCCAAATGCCGTCTTGGCTTTCGCCCAATGTATCCTGGGTGTTC,MAWYWWRRRRRRGWWKPRRRRWRRRRARRRGPARRHRARRRIVRHPCNGQTSSGNRVPRSVQAVDPKYVSLQLVWHSWDFRRGLFGQAGIKRMQQESDALTLSPVHRPKRPKRDTQVKEKTPEKDSDSAVQLRRLQPWIHSSQETKDEEEEIPEGPVQEQLLQQLQQQRLLRVQLESIAQEVLKIRRGHSLHPLLSSHA,negative +GCGACUGGUUACCCGGUCG,PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGKISKIGPENPYNTPVFAIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDESFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPXRXKNPEMVIYQYMDDLYVGSDLEIGQHRAKIEELRSHLLSWGFTTPDKKHQKEPPFLWMGYELHPDSWTVQPIELPEKDSWTVNE,negative +UUGUAAGCUCAACGGGUGGAGGGANCGGGCGAACGGGCUGGAGCACUACAAGCUUCUGGACUCGGU,MAITKINDCFELLSMVTYADKLKSLIKKEFSISFEEFAVLTYISENKEKEYYLKDIINHLNYKQPQVVKAVKILSQEDYFDKKRNEHDERTVLILVNAQQRKKIESLLSRVNKRITEANNEIEL,negative +CCGCCTCCTTCCGATTGAAAGGTCTGTTTTTGGGGTTGGTTTGGGTCAATAGGAGACGAGATAGGCGG,MSDNGPQSNQRSAPRITFGGPTDSTDNNQNGGRNGARPKQRRPQGLPNNTASWFTALTQHGKEELRFPRGQGVPINTNSGPDDQIGYYRRATRRVRGGDGKMKELSPRWYFYYLGTGPEASLPYGANKEGIVWVATEGALNTPKDHIGTRNPNNNAATVLQLPQGTTLPKGFYAEGSRGGSQASSRSSSRSRGNSRNSTPGSSRGNSPARMASGGGETALALLLLDRLNQLESKVSGKGQQQQGQTVTKKSAAEASKKPRQKRTATKQYNVTQAFGRRGPEQTQGNFGDQDLIRQGTDYKHWPQIAQFAPSASAFFGMSRIGMEVTPSGTWLTYHGAIKLDDKDPQFKDNVILLNKHIDAYKTFPPTEPKKDKKKKTDEAQPLPQRQKKQPTVTLLPAADMDDFSRQLQNSMSGASADSTQA,negative +CAGGAUGAACAAGCAGGACGUGAAAUGAAC,MQLPLALCLVCLLVHTAFRVVEGQGWQAFKNDATEIIPELGEYPEPPPELENNKTMNRAENGGRPPHHPFETKDVSEYSCRELHFTRYVTDGPCRSAKPVTELVCSGQCGPARLLPNAIGRGKWWRPSGPDFRCIPDRYRAQRVQLLCPGGEAPRARKVRLVASCKCKRLTRFHNQSELKDFGTEAARPQKGRKPRPRARSAKANQAELENAY,negative +AGCAACCU,MHGDTPTLHEYMLDLQPETTDLYCYEQLNDSSEEEDEIDGPAGQAEPDRAHYNIVTFCCKCDSTLRLCVQSTHVDIRTLEDLLMGTLGIVCPICSQKP,negative +AGUGAGGUCAACGAUCUUGGGCCCGUUGACGGGAAGCGUAGAACUACAAGCUUCUGGACUCGGU,MAGRSGDSDEELLKAVRLIKFLYQSNPPPNPEGTRQARRNRRRRWRERQRQIHSISERILSTYLGRSAEPVPLQLPPLERLTLDCNEDCGTSGTQGVGSPQILVESPTILESGAKE,negative +GGCGGCCGTGAAATTTGCCAAATGCCGTCTTGGCTTTCGCCCAATGTATCCTGGGTGTTC,MVMGLGVLLLVFVLGLGLTPPTLAQDNSRYTHFLTQHYDAKPQGRDDRYCESIMRRRGLTSPCKDINTFIHGNKRSIKAICENKNGNPHRENLRISKSSFQVTTCKLHGGSPWPPCQYRATAGFRNVVVACENGLPVHLDQSIFRRP,negative +UCCAAACCCCGUUGAGAGUUGAUCCGGUCUAGGGAAUGGAAAGAAGUAGGUAUCGAAGAGAAUGUACCCU,MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP,negative +TCCCACGCATTCTCCACATCCGCACGAGCATCGTACTTCCGTTATGATCATGAGACACAGCCTTTCTGTCCTTCCGTCAC,MGVHECPAWLWLLLSLLSLPLGLPVLGAPPRLICDSRVLERYLLEAKEAENITTGCAEHCSLNENITVPDTKVNFYAWKRMEVGQQAVEVWQGLALLSEAVLRGQALLVNSSQPWEPLQLHVDKAVSGLRSLTTLLRALGAQKEAISPPDAASAAPLRTITADTFRKLFRVYSNFLRGKLKLYTGEACRTGDR,negative +CTTGGATCACCATAGTCGCTAGTCGAGGCT,IMEIRTVAVGIVAIKGVESEYYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHSGGEMFVALNQKGLPVKGKKTKKEQKTAHFLPMAIT,negative +CCAGACGUUCUCGCCCCGCCGAUCAUCAGCGCUGGCCCUAU,MKKRKVLIPLMALSTILVSSTGNLEVIQAEVKQENRLLNESESSSQGLLGYYFSDLNFQAPMVVTSSTTGDLSIPSSELENIPSENQYFQSAIWSGFIKVKKSDEYTFATSADNHVTMWVDDQEVINKASNSNKIRLEKGRLYQIKIQYQRENPTEKGLDFKLYWTDSQNKKEVISSDNLQLPELKQKSSNSRKKRSTSAGPTVPDRDNDGIPDSLEVEGYTVDVKNKRTFLSPWISNIHEKKGLTKYKSSPEKWSTASDPYSDFEKVTGRIDKNVSPEARHPLVAAYPIVHVDMENIILSKNEDQSTQNTDSQTRTISKNTSTSRTHTSEVHGNAEVHASFFDIGGSVSAGFSNSNSSTVAIDHSLSLAGERTWAETMGLNTADTARLNANIRYVNTGTAPIYNVLPTTSLVLGKNQTLATIKAKENQLSQILAPNNYYPSKNLAPIALNAQDDFSSTPITMNYNQFLELEKTKQLRLDTDQVYGNIATYNFENGRVRVDTGSNWSEVLPQIQETTARIIFNGKDLNLVERRIAAVNPSDPLETTKPDMTLKEALKIAFGFNEPNGNLQYQGKDITEFDFNFDQQTSQNIKNQLAELNATNIYTVLDKIKLNAKMNILIRDKRFHYDRNNIAVGADESVVKEAHREVINSSTEGLLLNIDKDIRKILSGYIVEIEDTEGLKEVINDRYDMLNISSLRQDGKTFIDFKKYNDKLPLYISNPNYKVNVYAVTKENTIINPSENGDTSTNGIKKILIFSKKGYEIG,negative +UAUGAUGGUAGACGCCGUACCGCAUCAGGCCAAGUCGUCACAGAUCGUG,MEKVQYLTRSAIRRASTIEMPQQARQKLQNLFINFCLILICLLLICIIVMLL,negative +GGCAGCGAAAGCAGAAGAAGUAUGUGACCAUGCUUCGGCAACUUCACAUGCGUAGCCAAACCGA,MIPPPRRSASSTPKDYRSSRDLQPWRGVSSGDAAETSQQSRHRRDAIADGGGRLKGAAQSSPSSGTRRSGPYAQGRAMPKNENIPKPGKQRLGPRKKKLSTLKKKILLDRLERWRDKQHEGALSTPSATASSEEAKCNNPFPLCPPGELSPPPSPPATICPAVVDKSTSYGQVGGANGERSVWAITIYNLVDQEDVEDDDDHAEIERDLWDMSSAFGVVRSVQVPRGTAVQVSDAEVSAAAAAGEPAAVAAKVAFATNAEAECARDGLNGRIVGGKPLLVRIHRCDGHFCGGVCPGDPDGSGLWRVAIENLIDEEDDLDDEDEYAEISANVSAMMGCYGKLVDVQVRRSSPSKGEVQEDVATRAATTAGATQAVVVTFGSLAEAEACVQGIKGCRVGGKELDAHVVLDSERVLPSNPAFKCDQEHAHSSDVAAAVAGQGDSMMKQEAGTEPSPCVDQDTAAAVASSTEWRVVIRGLIDEDDLQDDDDDYAEVCSDVTALVSSYGAVVGLDIPRGRETGSCCYGAEPGEAVVVFRSLQEAEACARGLSGRKVAGNILDAQVLTQPAPSQQGPLQGGASGTGPPVANRERKPAKECPLPQHQASSHQSCGKVPELDGSGPGMLRGFGNRVEDCCGRPKIACTDSDEPQAIAAAAPPGQSIEGPKTTALAKAGKRIQTKYQEAAALPKPPGVRGGLPNAYVNQPPDKEVNDLVFEMLQLLFKFQERARLSDPSKAKTRRRLVIGLREVLRGVKAKKVRLLIVAPNVDAVGGEGGLDDKVVEIIDKAREAEYPVVFALSKRKIGKALGKTIKVSAVGVYSFDGANEQQKQLKRRMETISSLPSPSPRQSDPPTDDALASPPSSSACGDSQDPAGKGSRV,negative +AAUAACUC,MGVLLTQRTLLSLVLALLFPSMASMAAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQGLDVPKLREHCRERPGAFPSEETLRGLGRRGFLQTLNATLGCVLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILGLRNNIYCMAQLLDNSDTAEPTKAGRGASQPPTPTPASDAFQRKLEGCRFLHGYHRFMHSVGRVFSKWGESPNRSRRHSPHQALRKGVRRTRPSRKGKRLMTRGQLPR,negative +UAAUACGACUCACUAUAGGGAGGACGAUGCGGACAUAGUAAUGACACGGAGGAUGGAGAAAAAACAGCCAUCUCUUGACGGUUCGGGCGAGUCGUCUG,MLDLFADAEPWQEPLAAGAVILRRFAFNAAEQLIRDINDVASQSPFRQMVTPGGYTMSVAMTNCGHLGWTTHRQGYLYSPIDPQTNKPWPAMPQSFHNLCQRAATAAGYPDFQPDACLINRYAPGAKLSLHQDKDEPDLRAPIVSVSLGLPAIFQFGGLKRNDPLKRLLLEHGDVVVWGGESRLFYHGIQPLKAGFHPLTIDCRYNLTFRQAGKKE,negative +UGGUAGGACGGCACCGGAGAAAGGUAGCAUGAUAAGCGAGUACCUGCCGU,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,negative +GGACAANNAGCGGUGUCUUUUCAUUUNNAUCCUCCGACNUCC,PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGKISKIGPENPYNTPVFAIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDESFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPXRXKNPEMVIYQYMDDLYVGSDLEIGQHRAKIEELRSHLLSWGFTTPDKKHQKEPPFLWMGYELHPDSWTVQPIELPEKDSWTVNE,negative +GCAAUGGUACGGUACUUCCAAGUGCGGGGGGGAGGUGGUGGUUCCAAAAGUGCACGCUACUUUGCUAA,MAGRSGDSDEELLKAVRLIKFLYQSNPPPNPEGTRQARRNRRRRWRERQRQIHSISERILSTYLGRSAEPVPLQLPPLERLTLDCNEDCGTSGTQGVGSPQILVESPTILESGAKE,negative +CAUAGGCUUACAACAGAGCGGGGGUUCUGAUGGUAGACGCCGGGACGCCC,MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP,negative +TCCCACGCATTCTCCACATCCGCACGAGCATCGTACTTCCGTTATGATCATGAGACACAGCCTTTCTGTCCTTCCGTCAC,MLNQLDNLTERVRGSNKLVDRWLHVRKHLLVAYYNLVGIKPGKESYMRLNEKALDDFCQSLVDYLSAGHFSIYERILHKLEGNGQLARAAKIWPQLEANTQQIMDYYDSSLETAIDHDNYLEFQQVLSDIGEALEARFVLEDKLILLVLDAARVKHPA,negative +TAGGGAATTCGTCGACGGATCCCGATACGCACTACAAACGGCGCATGCGTCGACCTGGAG,MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPGPHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR,negative +CAGGAGGCTACTGTCCCTGGGC,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +ACAUUCCAAAUUACCCACCCACUGCUCCUAUCUG,MDKLVVNYYEYKHPIINKDLAIGAHGGKKFPTLGAWYDVINEYEFQTRCPIILKNSHRNKHFTFACHLKNCPFKVLLSYAGNAASSETSSPSANNNTNPPGTPDHIHHHSNNMNNEDNDNNNGSNNKVSNDSKLDFVTDDLEYHLANTHPDDTNDKVESRSNEVNGNNDDDADANNIFKQQGVTIKNDTEDDSINKASIDRGLDDESGPTHGNDSGNHRHNEEDDVHTQMTKNYSDVVNDEDINVAIANAVANVDSQSNNKHDGKDDDATNNNDGQDNNTNNDHNNNSNINNNNVGSHGISSHSPSSIRDTSMNLDVFNSATDDIPGPFVVTKIEPYHSHPLEDNLSLGKFILTKIPKILQNDLKFDQILESSYNNSNHTVSKFKVSHYVEESGLLDILMQRYGLTAEDFEKRLLSQIARRITTYKARFVLKKKKMGEYNDLQPSSSSNNNNNNDGELSGTNLRSNSIDYAKHQEISSAGTSSNTTKNVNNNKNDSNDDNNGNNNNDASNLMESVLDKTSSHRYQPKKMPSVNKWSKPDQITHSDVSMVGLDESNDGGNENVHPTLAEVDAQEARETAQLAIDKINSYKRSIDDKNGDGHNNSSRNVVDENLINDMDSEDAHKSKRQHLSDITLEERNEDDKLPHEVAEQLRLLSSHLKEVENLHQNNDDDVDDVMVDVDVESQYNKNTTHHNNHHSQPHHDEEDVAGLIGKADDEEDLSDENIQPELRGQ,negative +CGGTCGCTCCGTGTGGCTTGGGTTGGGTGTGGCAGTGAC,MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP,negative +AAGGACAGCACGAAUAAAACCUGCGUAAAUCCGCCCCAUUUGUGUAAGGGUAGUGGG,MKQYLNTVISNPRPAQALGINQPFVVFCFITSRALSFVPAIYWCFKCLHLAFVADKFKWLPLTSALWTLVSAYLSFVLANGFLLKWLIHYSIGPTIIRLFSLNVINFSFLSLSVSFITHGDNAYLLPAWIAISCFQTAAYIVQDWITSPIIRTLPFRSSSSSSSNYRHNLDFLEITVFAVVPVGIASFFTMVMLIWQLYKYPDSFLVSA,negative +TATTAGTAATCATATTAGTAATCA,MPSNQEARLFLAVLVLAQVLPILVDSAAEKGFKQAFWQPLCQVSEELDDQPKGALFTLQAAASKIQKMRDAALRASIYAEINHGTNRAKAAVIVANHYAMKADSGLEALKQTLSSQEVTATATASYLKGRIDEYLNLLLQTKESGTSGCMMDTSGTNTVTKAGGTIGGVPCKLQLSPIQPKRPAATYLGKAGYVGLTRQADAANNFHDNDAECRLASGHNTNGLGKSGQLSAAVTMAAGYVTVANSQTAVTVQALDALQEASGAAHQPWIDAWKAKKALTGAETAEFRNETAGIAGKTGVTKLVEEALLKKKDSEASEIQTELKKYFSGHENEQWTAIEKLISEQPVAQNLVGDNQPTKLGELEGNAKLTTILAYYRMETAGKFEVLTQKHKPAESQQQAAETEGSCNKKDQNECKSPCKWHNDAENKKCTLDKEEAKKVADETAKDGKTGNTNTTGSSNSFVISKTPLWLAVLLF,negative +GGGAUCGUGGUAGUGCGAAGCCAGUAAACGAGGGCACCACGGUCC,MSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA,negative +CGTACGAAATTCGTACCTGTGTG,MAGRSGDSDEELLKAVRLIKFLYQSNPPPNPEGTRQARRNRRRRWRERQRQIHSISERILSTYLGRSAEPVPLQLPPLERLTLDCNEDCGTSGTQGVGSPQILVESPTILESGAKE,negative +GAAGTGAAAATGACAGAACACAACA,MNQVTIQWDAVIALYILFSWCHGGITNINCSGHIWVEPATIFKMGMNISIYCQAAIKNCQPRKLHFYKNGIKERFQITRINKTTARLWYKNFLEPHASMYCTAECPKHFQETLICGKDISSGYPPDIPDEVTCVIYEYSGNMTCTWNAGKLTYIDTKYVVHVKSLETEEEQQYLTSSYINISTDSLQGGKKYLVWVQAANALGMEESKQLQIHLDDIVIPSAAVISRAETINATVPKTIIYWDSQTTIEKVSCEMRYKATTNQTWNVKEFDTNFTYVQQSEFYLEPNIKYVFQVRCQETGKRYWQPWSSLFFHKTPETVPQVTSKAFQHDTWNSGLTVASISTGHLTSDNRGDIGLLLGMIVFAVMLSILSLIGIFNRSFRTGIKRRILLLIPKWLYEDIPNMKNSNVVKMLQENSELMNNNSSEQVLYVDPMITEIKEIFIPEHKPTDYKKENTGPLETRDYPQNSLFDNTTVVYIPDLNTGYKPQISNFLPEGSHLSNNNEITSLTLKPPVDSLDSGNNPRLQKHPNFAFSVSSVNSLSNTIFLGELSLILNQGECSSPDIQNSVEEETTMLLENDSPSETIPEQTLLPDEFVSCLGIVNEELPSINTYFPQNILESHFNRISLLEK,negative +GTCAAGNACGCGAACCCCGCATTCCCAAGAACGGCAACCCT,MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINYDEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQAVAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQGIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADMDFSALLSQISS,negative +CGCACTGAAGTGGGATACCGCCTAAACGG,MPSNQEARLFLAVLVLAQVLPILVDSAAEKGFKQAFWQPLCQVSEELDDQPKGALFTLQAAASKIQKMRDAALRASIYAEINHGTNRAKAAVIVANHYAMKADSGLEALKQTLSSQEVTATATASYLKGRIDEYLNLLLQTKESGTSGCMMDTSGTNTVTKAGGTIGGVPCKLQLSPIQPKRPAATYLGKAGYVGLTRQADAANNFHDNDAECRLASGHNTNGLGKSGQLSAAVTMAAGYVTVANSQTAVTVQALDALQEASGAAHQPWIDAWKAKKALTGAETAEFRNETAGIAGKTGVTKLVEEALLKKKDSEASEIQTELKKYFSGHENEQWTAIEKLISEQPVAQNLVGDNQPTKLGELEGNAKLTTILAYYRMETAGKFEVLTQKHKPAESQQQAAETEGSCNKKDQNECKSPCKWHNDAENKKCTLDKEEAKKVADETAKDGKTGNTNTTGSSNSFVISKTPLWLAVLLF,negative +AGCGACTGACGATCTTGAGTAAACCGCTCATCCACGTAGT,MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA,negative +CAGCTCAGAAGCTTGATCCTGTGCAGCCGGGGGACAAGCGCGTTGGCCAGATCATCCGACTCGAAGTCGTGCATCTGCA,QSVEESRGGLIKPTDTLTLTCTVSGFSLSSYGEVWDRQAPGNGLEYIGAIGNSGSTYYASWAKSRSTITRNTNLNTVTLKMTSLTAADTATYFCAR,negative +CAUGAGGUCUAUCACUGCAUCGACAGCUAGGCGGACAAUG,ASFTCLAIWALASAGVVPLVLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAAFFFVPVIISTVCYVSIIRCLSSSAVANRSKK,negative +UGUUGUUGGACCAGUGUUAUUUUACGCGAUUGUGCGGUUGUGA,MKPSIVAKLEALHERHEEVQALLGDAQTIADQERFRALSREYAQLSDVSRCFTDWQQVQEDIETAQMMLDDPEMREMAQDELREAKEKSEQLEQQLQVLLLPKDPDDERNAFLEVRAGTGGDEAALFAGDLFRMYSRYAEARRWRVEIMSASEGEHGGYKEIIAKISGDGVYGRLKFESGGHRVQRVPATESQGRIHTSACTVAVMPELPDAELPDINPADLRIDTFRSSGAGGQHVNTTDSAIRITHLPTGIVVECQDERSQHKNKAKALSVLGARIHAAEMAKRQQAEASTRRNLLGSGDRSDRNRTYNFPQGRVTDHRINLTLYRLDEVMEGKLDMLIEPIIQEHQADQLAALSEQE,negative +CACGATGGTTAGGCGGGCCTTGAGGCTAATAATGTTGTTA,MHGDTPTLHEYMLDLQPETTDLYCYEQLNDSSEEEDEIDGPAGQAEPDRAHYNIVTFCCKCDSTLRLCVQSTHVDIRTLEDLLMGTLGIVCPICSQKP,negative +UGCGAUAAGGUGGUAGCGACAGUGAUAGAAGC,ASFTCLAIWALASAGVVPLVLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAAFFFVPVIISTVCYVSIIRCLSSSAVANRSKK,negative +TCCCTACGGCGCTAACGACGGGGGAGTTGTGCTCCCGAAAGGAGGTGCCACCGTGCTACAAC,MSGGDGRGHNTGAHSTSGNINGGPTGLGVGGGASDGSGWSSENNPWGGGSGSGIHWGGGSGHGNGGGNGNSGGGSGTGGNLSAVAAPVAFGFPALSTPGAGGLAVSISAGALSAAIADIMAALKGPFKFGLWGVALYGVLPSQIAKDDPNMMSKIVTSLPADDITESPVSSLPLDKATVNVNVRVVDDVKDERQNISVVSGVPMSVPVVDAKPTERPGVFTASIPGAPVLNISVNNSTPAVQTLSPGVTNNTDKDVRPAGFTQGGNTRDAVIRFPKDSGHNAVYVSVSDVLSPDQVKQRQDEENRRQQEWDATHPVEAAERNYERARAELNQANEDVARNQERQAKAVQVYNSRKSELDAANKTLADAIAEIKQFNRFAHDPMAGGHRMWQMAGLKAQRAQTDVNNKQAAFDAAAKEKSDADAALSSAMESRKKKEDKKRSAENNLNDEKNKPRKGFKDYGHDYHPAPKTENIKGLGDLKPGIPKTPKQNGGGKRKRWTGDKGRKIYEWDSQHGELEGYRASDGQHLGSFDPKTGNQLKGPDPKRNIKKYL,negative +GAAGCUUACAAGAAGGACAGCACGAAUAAAACCUGCGUAAAUCCGCCCCAUUUGUGUAAAAAAAAAAAAAAAAAAAAAAAAA,MDSTNYISKLFEYAQRQGQISDIKFEEVGTDGPDHLKTFTLRVVIKGHAYPNGVGKTKKEAKRNAAKHALIGMMETTEQKDASVSCPPSPAPSPAPPVRAVISQPKYVSWLNEHSQKNKLSLKALEGARVGPNNTSQCCRYVVGEKEYPEGFGNTKKEAKEEAAMQVYLELCGGSQTTGTVDENCNGTTGKHKEELNGKVVVLSEKVEHMNMSPAQNVPEQYSFITTEETNFIGILNHYCQKTKRFLDFKLVEKSGPSHNPQFVYKVLIDKREYPDGLGKTAKEAKQQAAQLAWSALQEQSDWNSQVSCRSTVSEEGGLSSLTPSSTWESQDATPSSLSIAGSTSESIIFSDSVNVSSPKDESPVNVKPKIRLAANFQMSPVKTKQEGPNLKGNDLGTLSSGRTSNQPVISRFSSEFDSIENIGKGGFGHVYKARRKLEQKYFAVKIVRSKGKAKREVGALADLQHPNIVRYYTAWLEDTAYRCDTASESDTTSDSGSSSSSEFLYIQMELCDKRTLKVWIDERNAHRKPKRREESLSITQQIVNGVEYIHSKKLLHRDLKPANIMFGMSDGEGKGEVKIGDFGLVTAEDNDNDENLLERTKKTGTVSYMAPEQRNQTSYDRKVDIFALGLIYFEPLWDLSGMEKAKVWNDVRSQRFPQQFNSQFTLENKVIESLLCANPEERPDARQLKTKLNECSRVLTRVHNIHQDNRTI,negative +GGGACACAAUGGACGAAGCCAGUCGCAUUGGCCGAGCUGUCGCUCUGACCAACUGGUAACGGCCGACAUGAGAG,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,negative +GGGAACUCGAUGAAGCGAAUUCUGUUGGCGAACUGUACGCAAGUACACUGGAUGACAGGCCUAUCUAUCGGAUCCACG,MVKSHIGSWILVLFVAMWSDVGLCKKRPKPGGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGSHSQWNKPSKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGNDYEDRYYRENMYRYPNQVYYRPVDRYSNQNNFVHDCVNITVKQHTVTTTTKGENFTETDIKIMERVVEQMCITQYQRESQAYYQRGASVILFSSPPVILLISFLIFLIVG,negative +UUGUAAUGUAUACCGCGCGCCC,MPFVNKQFNYKDPVNGVDIAYIKIPNVGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAGHRLYGIAINPNRVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNRKTYLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLKNFTGLFEFYKLLCVRGIITSKTKSLDKGYNKALNDLCIKVNNWDLFFSPSEDNFTNDLNKGEEITSDTNIEAAEENISLDLIQQYYLTFNFDNEPENISIENLSSDIIGQLELMPNIERFPNGKKYELDKYTMFHYLRAQEFEHGKSRIALTNSVNEALLNPSRVYTFFSSDYVKKVNKATEAAMFLGWVEQLVYDFTDETSEVSTTDKIADITIIIPYIGPALNIGNMLYKDDFVGALIFSGAVILLEFIPEIAIPVLGTFALVSYIANKVLTVQTIDNALSKRNEKWDEVYKYIVTNWLAKVNTQIDLIRKKMKEALENQAEATKAIINYQYNQYTEEEKNNINFNIDDLSSKLNESINKAMININKFLNQCSVSYLMNSMIPYGVKRLEDFDASLKDALLKYIYDNRGTLIGQVDRLKDKVNNTLSTDIPFQLSKYVDNQRLLSTFTEYIKNIINTSILNLRYESNHLIDLSRYASKINIGSKVNFDPIDKNQIQLFNLESSKIEVILKNAIVYNSMYENFSTSFWIRIPKYFNSISLNNEYTIINCMENNSGWKVSLNYGEIIWTLQDTQEIKQRVVFKYSQMINISDYINRWIFVTITNNRLNNSKIYINGRLIDQKPISNLGNIHASNNIMFKLDGCRDTHRYIWIKYFNLFDKELNEKEIKDLYDNQSNSGILKDFWGDYLQYDKPYYMLNLYDPNKYVDVNNVGIRGYMYLKGPRGSVMTTNIYLNSSLYRGTKFIIKKYASGNKDNIVRNNDRVYINVVVKNKEYRLATNASQAGVEKILSALEIPDVGNLSQVVVMKSKNDQGITNKCKMNLQDNNGNDIGFIGFHQFNNIAKLVASNWYNRQIERSSRTLGCSWEFIPVDDGWGERPL,negative +GGGACACAAUGGACGUCCGUAGAAACGCGUUAAGGUGAAAGUUUGAGGGCUCCUCAUAACGGCCGACAUGAGAG,IMEIRTVAVGIVAIKGVESEYYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHSGGEMFVALNQKGLPVKGKKTKKEQKTAHFLPMAIT,negative +CCGTAGGTTCGGGGCGGAGTGGTCCGGAAGGTGGCGTGG,MSDRKKIEIDAIDKKLLIELLKDSRISLRRLAEEMNVSPATLHNRLMRLVQEGVVKGFTALIDYSKLGYPVTSILMIKVDGKHILEFEKEVSNLDNVVAVYDVVGEYDVMLIAKFRSIEDLDTFIKSLLKNPKIERTYTSIVLNVVKEDPRIKII,negative +GGTTGGTTTGGTTGG,MAGRSGDSDEELLKAVRLIKFLYQSNPPPNPEGTRQARRNRRRRWRERQRQIHSISERILSTYLGRSAEPVPLQLPPLERLTLDCNEDCGTSGTQGVGSPQILVESPTILESGAKE,negative +TATTAGTCATAATATTAGTCATAA,MGVLLTQRTLLSLVLALLFPSMASMAAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQGLDVPKLREHCRERPGAFPSEETLRGLGRRGFLQTLNATLGCVLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILGLRNNIYCMAQLLDNSDTAEPTKAGRGASQPPTPTPASDAFQRKLEGCRFLHGYHRFMHSVGRVFSKWGESPNRSRRHSPHQALRKGVRRTRPSRKGKRLMTRGQLPR,negative +UAAACCUGCUGGCAGUGUGACCUAAGGACCAAGCCGUUCCUGAGGAACGUC,MRKIVVAAIAVSLTTVSITASASADPSKDSKAQVSAAEAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKVKPSAASIDAAKKAGVNNGNPLDAVQQ,negative +CTTCTGCCCGCCTCCTTCCTCGGGGTTAGAACGTCGTGTAGGACTCCTATCGGTTTATGGAGACGAGATAGGCGGACACT,MLSWGYFLFLLPTLPGAQSQVQLVESGGDVRKPGDSLRLSCKGSGFTFSNYWLGWVRQAPGKALNGSLPLTPLAAAPTYIPGVSGRFTISRDNARALLHLDMSDLRPEDTGRYHCER,negative +GGGGCCACCAACGACAUUUAUCGAAUUGAUAACCUUACGCGAGAGCGUAGUUCGUUGAUAUAAAUAGUGCCCAUGGAUC,MSGGDGRGHNTGAHSTSGNINGGPTGLGVGGGASDGSGWSSENNPWGGGSGSGIHWGGGSGHGNGGGNGNSGGGSGTGGNLSAVAAPVAFGFPALSTPGAGGLAVSISAGALSAAIADIMAALKGPFKFGLWGVALYGVLPSQIAKDDPNMMSKIVTSLPADDITESPVSSLPLDKATVNVNVRVVDDVKDERQNISVVSGVPMSVPVVDAKPTERPGVFTASIPGAPVLNISVNNSTPAVQTLSPGVTNNTDKDVRPAGFTQGGNTRDAVIRFPKDSGHNAVYVSVSDVLSPDQVKQRQDEENRRQQEWDATHPVEAAERNYERARAELNQANEDVARNQERQAKAVQVYNSRKSELDAANKTLADAIAEIKQFNRFAHDPMAGGHRMWQMAGLKAQRAQTDVNNKQAAFDAAAKEKSDADAALSSAMESRKKKEDKKRSAENNLNDEKNKPRKGFKDYGHDYHPAPKTENIKGLGDLKPGIPKTPKQNGGGKRKRWTGDKGRKIYEWDSQHGELEGYRASDGQHLGSFDPKTGNQLKGPDPKRNIKKYL,negative +CAGCUAGAGGCAAAGUGGUCUCGACGUAGGGGGACCUGCUCGCUG,MSARGEEAAGEASGSQEQPEPALAEPKKRGPGRPRKPQQEPTGEPVPKRPRGRPKGSKNKGPSKAAQKKAETTGEKRPRGRPRKWPQQVVQEKPAQEEEEEEEEEEAEED,negative +AGGGAGCAAUGAACUCAAGUCAAGCCGGGCACGUGGG,MSMSPKHTTPFSVSDILSPLEESYKKVGMEGGGLGAPLAAYRQGQAAPPAAAMQQHAVGHHGAVTAAYHMTAAGVPQLSHSAVGGYCNGNLGNMSELPPYQDTMRNSASGPGWYGANPDPRFPAISRFMGPASGMNMSGMGGLGSLGDVSKNMAPLPSAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGGGGGGGAGCPQQQQAQQQSPRRVAVPVLVKDGKPCQAGAPAPGAGSLQGHAQQQAQQQAQAAQAAAAAISVGSGGPGLGAHPGHQPGSAGQSPDLAHHAASPAALQGQVSSLSHLNSSGSDYGTMSCSTLLYGRTW,negative +GGCUUAGCUAAACGUAGCGGGUAUCGAACGCGAGCGGCAUGCCGAUAUCAUGAGUAGCCGUGAUAGCAUGCUGCUCGGAUAAGCA,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,negative +ATACCAGCTTATTCAATTCAAGTTGCTGTGGGACAGAAACGGGCGCTAGACTATGCATAGATAGTAAGTGCAATCT,MKRASAGGSRLLAWVLWLQAWQVAAPCPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDNPWVCDCRARPLWAWLQKFRGSSSEVPCSLPQRLAGRDLKRLAANDLQGCAVATGPYHPIWTGRATDEEPLGLPKCCQPDAADKASVLEPGRPASAGNALKGRVPPGDSPPGNGSGPRHINDSPFGTLPGSAEPPLTAVRPEGSEPPGFPTSGPRRRPGCSRKNRTRSHCRLGQAGSGGGGTGDSEGSGALPSLTCSLTPLGLALVLWTVLGPC,negative +CTTCTGCCCGCCTCCTTCCAGAGTAGCCAAGCGGAGAGTATTTTTGACTGCTTCCCCCGGAGACGAGATAGGCGGACACT,MSKSESPKEPEQLRKLFIGGLSFETTDESLRSHFEQWGTLTDCVVMRDPNTKRSRGFGFVTYATVEEVDAAMNARPHKVDGRVVEPKRAVSREDSQRPGAHLTVKKIFVGGIKEDTEEHHLRDYFEQYGKIEVIEIMTDRGSGKKRGFAFVTFDDHDSVDKIVIQKYHTVNGHNCEVRKALSKQEMASASSSQRGRSGSGNFGGGRGGGFGGNDNFGRGGNFSGRGGFGGSRGGGGYGGSGDGYNGFGNDGGYGGGGPGYSGGSRGYGSGGQGYGNQGSGYGGSGSYDSYNNGGGGGFGGGSGSNFGGGGSYNDFGNYNNQSSNFGPMKGGNFGGRSSGPYGGGGQYFAKPRNQGGYGGSSSSSSYGSGRRF,negative +GGAAAAGATGGTATGGGCCCTAGAAAGTCCACCCGGCGCC,ASFTCLAIWALASAGVVPLVLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAAFFFVPVIISTVCYVSIIRCLSSSAVANRSKK,negative +CGAUACAGCACUGAUUGCGGUCGAGGUAGCUUGAUGGGCC,MVMGLGVLLLVFVLGLGLTPPTLAQDNSRYTHFLTQHYDAKPQGRDDRYCESIMRRRGLTSPCKDINTFIHGNKRSIKAICENKNGNPHRENLRISKSSFQVTTCKLHGGSPWPPCQYRATAGFRNVVVACENGLPVHLDQSIFRRP,negative +AAGACGGCCGGGGAAACCCGAGGUCCGAGGUAACGC,MANLGYWLLALFVTMWTDVGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGTWGQPHGGGWGQPHGGSWGQPHGGSWGQPHGGGWGQGGGTHNQWNKPSKPKTNLKHVAGAAAAGAVVGGLGGYMLGSAMSRPMIHFGNDWEDRYYRENMYRYPNQVYYRPVDQYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCVTQYQKESQAYYDGRRSSSTVLFSSPPVILLISFLIFLIVG,negative +GGGAGAGGAGAGAACGUUCUACGUCGUGAGUAAUGGCUCGUAGAUGAGGUCGCUGUCGAUCGAUCGAUCGAUG,MKPGGNTIVIWMYAVATWLCFGSTSGWSFTLEDNNIFPKQYPIINFTTAGATVQSYTNFIRAVRGRLTTGADVRHEIPVLPNRVGLPINQRFILVELSNHAELSVTLALDVTNAYVVGYRAGNSAYFFHPDNQEDAEAITHLFTDVQNRYTFAFGGNYDRLEQLAGNLRENIELGNGPLEEAISALYYYSTGGTQLPTLARSFIICIQMISEAARFQYIEGEMRTRIRYNRRSAPDPSVITLENSWGRLSTAIQESNQGAFASPIQLQRRNGSKFSVYDVSILIPIIALMVYRCAPPPSSQFSLLIRPVVPNFNADVCMDPEPIVRIVGRNGLCVDVRDGRFHNGNAIQLWPCKSNTDANQLWTLKRDNTIRSNGKCLTTYGYSPGVYVMIYDCNTAATDATRWQIWDNGTIINPRSSLVLAATSGNSGTTLTVQTNIYAVSQGWLPTNNTQPFVTTIVGLYGLCLQANSGQVWIEDCSSEKAEQQWALYADGSIRPQQNRDNCLTSDSNIRETVVKILSCGPASSGQRWMFKNDGTILNLYSGLVLDVRASDPSLKQIILYPLHGDPNQIWLPLF,negative +CGTACCAAGATCCCACAACTAGCCGACCAGGATTGCCGGC,ASFTCLAIWALASAGVVPLVLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAAFFFVPVIISTVCYVSIIRCLSSSAVANRSKK,negative +AATACGTGCTCCCTCCGCCAAAGGCGGAGGGAGCACG,MAAKVASTSSEEAEGSLVTEGEMGEKALPVVYKRYICSFADCGAAYNKNWKLQAHLCKHTGEKPFPCKEEGCEKGFTSLHHLTRHSLTHTGEKNFTCDSDGCDLRFTTKANMKKHFNRFHNIKICVYVCHFENCGKAFKKHNQLKVHQFSHTQQLPYECPHEGCDKRFSLPSRLKRHEKVHAGYPCKKDDSCSFVGKTWTLYLKHVAECHQDLAVCDVCNRKFRHKDYLRDHQKTHEKERTVYLCPRDGCDRSYTTAFNLRSHIQSFHEEQRPFVCEHAGCGKCFAMKKSLERHSVVHDPEKRKLKEKCPRPKRSLASRLTGYIPPKSKEKNASVSGTEKTDSLVKNKPSGTETNGSLVLDKLTIQ,negative +AATACGACTCACTATAGAGGGAGGACGATGCGGGATGGACGCTTATCCGCATAGAGGTTTACTACTTCGGAGACTGCCGATACAGACGACGGA,PHITDVVLDKANKTPLRQLDPSRLPDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFAKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRQSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPINRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDTASEATRPATLNRFSALQQTLPAENTDNRRVVQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRTRTPATKRSFSKEVEERSRERPSQPEGLRKAASLTEDRGRDPVKREATLPPVSPPKAALSVDEVEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRLGIESTLERSTIAREHMGRLLHQLLCAGHLSTAQYYQGLYETLELAEDMEIDIPHVWLYLAELITPILQEDGVPMGELFREITKPLRPMGKATSLLLEILGLLCKSMGPKKVGMLWREAGLSWREFLAEGQDVGSFVAEKKVEYTLGEESEAPGQRTLAFEELRRQLEKLLKDGGSNQRVFDWIDANLNEQQIASNTLVRALMTTVCYSAIIFETPLRVDVQVLKVRARLLQKYLCDEQKELQALYALQALVVTLEQPANLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFNWLREAEDEESDHN,negative +TCTCATGCGCCGAGTGTGAGTTTACCTTCGT,PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGKISKIGPENPYNTPVFAIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDESFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPXRXKNPEMVIYQYMDDLYVGSDLEIGQHRAKIEELRSHLLSWGFTTPDKKHQKEPPFLWMGYELHPDSWTVQPIELPEKDSWTVNE,negative +UGACUCCUCUGACAGCCUAAUUUCUCCCGAUUACCCUG,MGLLGILCFLIFLGKTWGQEQTYVISAPKIFRVGASENIVIQVYGYTEAFDATISIKSYPDKKFSYSSGHVHLSSENKFQNSAILTIQPKQLPGGQNPVSYVYLEVVSKHFSKSKRMPITYDNGFLFIHTDKPVYTPDQSVKVRVYSLNDDLKPAKRETVLTFIDPEGSEVDMVEEIDHIGIISFPDFKIPSNPRYGMWTIKAKYKEDFSTTGTAYFEVKEYVLPHFSVSIEPEYNFIGYKNFKNFEITIKARYFYNKVVTEADVYITFGIREDLKDDQKEMMQTAMQNTMLINGIAQVTFDSETAVKELSYYSLEDLNNKYLYIAVTVIESTGGFSEEAEIPGIKYVLSPYKLNLVATPLFLKPGIPYPIKVQVKDSLDQLVGGVPVTLNAQTIDVNQETSDLDPSKSVTRVDDGVASFVLNLPSGVTVLEFNVKTDAPDLPEENQAREGYRAIAYSSLSQSYLYIDWTDNHKALLVGEHLNIIVTPKSPYIDKITHYNYLILSKGKIIHFGTREKFSDASYQSINIPVTQNMVPSSRLLVYYIVTGEQTAELVSDSVWLNIEEKCGNQLQVHLSPDADAYSPGQTVSLNMATGMDSWVALAAVDSAVYGVQRGAKKPLERVFQFLEKSDLGCGAGGGLNNANVFHLAGLTFLTNANADDSQENDEPCKEILRPRRTLQKKIEEIAAKYKHSVVKKCCYDGACVNNDETCEQRAARISLGPRCIKAFTECCVVASQLRANISHKDMQLGRLHMKTLLPVSKPEIRSYFPESWLWEVHLVPRRKQLQFALPDSLTTWEIQGVGISNTGICVADTVKAKVFKDVFLEMNIPYSVVRGEQIQLKGTVYNYRTSGMQFCVKMSAVEGICTSESPVIDHQGTKSSKCVRQKVEGSSSHLVTFTVLPLEIGLHNINFSLETWFGKEILVKTLRVVPEGVKRESYSGVTLDPRGIYGTISRRKEFPYRIPLDLVPKTEIKRILSVKGLLVGEILSAVLSQEGINILTHLPKGSAEAELMSVVPVFYVFHYLETGNHWNIFHSDPLIEKQKLKKKLKEGMLSIMSYRNADYSYSVWKGGSASTWLTAFALRVLGQVNKYVEQNQNSICNSLLWLVENYQLDNGSFKENSQYQPIKLQGTLPVEARENSLYLTAFTVIGIRKAFDICPLVKIDTALIKADNFLLENTLPAQSTFTLAISAYALSLGDKTHPQFRSIVSALKREALVKGNPPIYRFWKDNLQHKDSSVPNTGTARMVETTAYALLTSLNLKDINYVNPVIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVKQLRLSMDIDVSYKHKGALHNYKMTDKNFLGRPVEVLLNDDLIVSTGFGSGLATVHVTTVVHKTSTSEEVCSFYLKIDTQDIEASHYRGYGNSDYKRIVACASYKPSREESSSGSSHAVMDISLPTGISANEEDLKALVEGVDQLFTDYQIKDGHVILQLNSIPSSDFLCVRFRIFELFEVGFLSPATFTVYEYHRPDKQCTMFYSTSNIKIQKVCEGAACKCVEADCGQMQEELDLTISAETRKQTACKPEIAYAYKVSITSITVENVFVKYKATLLDIYKTGEAVAEKDSEITFIKKVTCTNAELVKGRQYLIMGKEALQIKYNFSFRYIYPLDSLTWIEYWPRDTTCSSCQAFLANLDEFAEDIFLNGC,negative +GGGACACAAUGGACGAAGUCAGUCGCAUUGGCCGAGCUGUCGCUCUGACCAACUGAUAACGGCCGACAUGAGAG,MASTSRLDALPRVTCPNHPDAILVEDYRAGDMICPECDRVIDVGSEWRTFSNDKATKDPSRVGDSQNPLLSDGDLSTMIGKGTGAASFDEFGNSKYQNRRTMSSSDRAMMNAFKEITTMADRINLPRNIVDRTNNLFKQVYEQKSLKGRANDAIASACLYIACRQEGVPRTFKEICAVSRISKKEIGRCFKLILKALETSVDLITTGDFMSRFCSNLCLPKQVQMAATHIA,negative +UCGUGCCUUUUCUCGAUGGAGUGAGAAGAGGUGACGG,XQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGSTGSPGPGYGYSNYGFPPYGGITFHPGVTKSNAGVTHGTINTKFKNGPKDCAKSDDEESLTLPEKETEGEGPSLPMACTKTEPIALASTMEDKEQDMGFQDNLFLEKALQLARRHANALFDYAVTGDVKMLLAVQRHLTAVQDENGDSVLHLAIIHLHAQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRVGADLSLLDRWGNSVLHLAAKEGHDRILSILLKSRKAAPLIDHPNGEGLNAIHIAVMSNSLPCLLLLVAAGAEVNAQEQKSGRTALHLAVEYDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWEKAGEDEGVVPGTTPLDMAANWQVFDILNGKPYEPVFTSDDILPQGDMKQLTEDTRLQLCKLLEIPDPDKNWATLAQKLGLGILNNAFRLSPAPSKTLMDNYEMNSGIVTASVTVVWRHPSANSALQSLLLETAHCYL,negative +CGCGGATCCTGCAGCTCGAGTGGGTAAACAACAACATGTTGACATCGCGGCTCTAGAAGCTTGTCGAC,WWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMKSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGSKGKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMKVAKNAQNINPTSLQNSQNFA,negative +UUUCUGUGAUCUUUGCUCGGAAUGGCUGUGGGUAUGGGUGGGUUGGGCUAG,EFPPSTFYRVTLYGLYKGELLDPVFAEAITEAEPEVEHITVSDITPHSFKVTWTAPEAVFDSFALKVLDSSGLGRPHQISVSGDKRTEAVTGLNEDTDYEIELFGIILGRKFQPIFTVARTGLGTRKGIRFSDVTDTSATVHWTMPHTRVDNYRVIYVPIQGGSPLTLRVDGGESQAMLSNLTPGVTYQVTVIAVKGLEESEPGSERVTTALDKPRGLTAVNISDTEALLLWQPSIATVDGYVITYSADSVAPVMERVSGNTVEFEMSSLTPATLYTVKVYAFRDTAKSAATSTDFTTDVDAPQNLAASNIQTETAMLTWKPPRADISGYILSFESADGVVKEVVLSPTATFYSMSHLTASTEYTVKLQAIAGPKRSRVISTVFLTIGVLYKHPKDCSQALLNGDTTSGFYTIYLRGDESQPLQVYCDMTTDGGGWIVFVRRQSGKVEFFRNWKNYTAGFGDLNDEFWLGLSNLHKITSFGQYELRVDLRDKGESAYAQYDKFSISEPRARYKVHVGGYSGTAGDSMTYHHGRPFSTYDNDNDIAVTNCALSYKGAFWYKNCHRVNIMGRYGDNSHSKGVNWFHWKGHEHSVEFAEMKIRPANFRNFEGRKKRS,negative +ACACGACGGGAATACTGACTCTCCCCCATGT,MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINYDEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQAVAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQGIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADMDFSALLSQISS,negative +AATATCCCCCCTTCGGTGCAAAGCACCGAAGGGGGGA,MSWLLFLAHRVALAALPCRRGSRGFGMFYAVRRGRKTGVFLTWNECRAQVDRFPAARFKKFATEDEAWAFVRKSASPEVSEGHENQHGQESEAKASKRLREPLDGDGHESAEPYAKHMKPSVEPAPPVSRDTFSYMGDFVVVYTDGCCSSNGRRRPRAGIGVYWGPGHPLNVGIRLPGRQTNQRAEIHAACKAIEQAKTQNINKLVLYTDSMFTINGITNWVQGWKKNGWKTSAGKEVINKEDFVALERLTQGMDIQWMHVPGHSGFIGNEEADRLAREGAKQSED,negative +BAGCGCCGGTGGTGGTGGGGGTTGTTGTTACGCGGTATTAT,VENLMVQELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFSHFRLFDENNDAAILILLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVN,negative +GGAGUCUUAGGCAGCGCGUUUUCGAGCUACUCCA,MNQTAILICCLIFLTLSGIQGVPLSRTVRCTCISISNQPVNPRSLEKLEIIPASQFCPRVEIIATMKKKGEKRCLNPESKAIKNLLKAVSKERSKRSP,negative +GGGAGCUCAGCCUUCACUGCCUACGCGGGCGUUUACGUAACGGCUUAUGGGGAGCUGAGCGCUUGAUCGUGGUAGUGCGAAGCCAGUAAACGAGGGCACCACGGUCGGAUCCAC,MSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA,negative +GGAATGAGTGCCCTGCAAGCGAGGGCTAGC,MSGGDGRGHNTGAHSTSGNINGGPTGLGVGGGASDGSGWSSENNPWGGGSGSGIHWGGGSGHGNGGGNGNSGGGSGTGGNLSAVAAPVAFGFPALSTPGAGGLAVSISAGALSAAIADIMAALKGPFKFGLWGVALYGVLPSQIAKDDPNMMSKIVTSLPADDITESPVSSLPLDKATVNVNVRVVDDVKDERQNISVVSGVPMSVPVVDAKPTERPGVFTASIPGAPVLNISVNNSTPAVQTLSPGVTNNTDKDVRPAGFTQGGNTRDAVIRFPKDSGHNAVYVSVSDVLSPDQVKQRQDEENRRQQEWDATHPVEAAERNYERARAELNQANEDVARNQERQAKAVQVYNSRKSELDAANKTLADAIAEIKQFNRFAHDPMAGGHRMWQMAGLKAQRAQTDVNNKQAAFDAAAKEKSDADAALSSAMESRKKKEDKKRSAENNLNDEKNKPRKGFKDYGHDYHPAPKTENIKGLGDLKPGIPKTPKQNGGGKRKRWTGDKGRKIYEWDSQHGELEGYRASDGQHLGSFDPKTGNQLKGPDPKRNIKKYL,negative +GUAUAUGUAUGUGUUGUUUUAUUGUGUGUGUGUGU,MKPGGNTIVIWMYAVATWLCFGSTSGWSFTLEDNNIFPKQYPIINFTTAGATVQSYTNFIRAVRGRLTTGADVRHEIPVLPNRVGLPINQRFILVELSNHAELSVTLALDVTNAYVVGYRAGNSAYFFHPDNQEDAEAITHLFTDVQNRYTFAFGGNYDRLEQLAGNLRENIELGNGPLEEAISALYYYSTGGTQLPTLARSFIICIQMISEAARFQYIEGEMRTRIRYNRRSAPDPSVITLENSWGRLSTAIQESNQGAFASPIQLQRRNGSKFSVYDVSILIPIIALMVYRCAPPPSSQFSLLIRPVVPNFNADVCMDPEPIVRIVGRNGLCVDVRDGRFHNGNAIQLWPCKSNTDANQLWTLKRDNTIRSNGKCLTTYGYSPGVYVMIYDCNTAATDATRWQIWDNGTIINPRSSLVLAATSGNSGTTLTVQTNIYAVSQGWLPTNNTQPFVTTIVGLYGLCLQANSGQVWIEDCSSEKAEQQWALYADGSIRPQQNRDNCLTSDSNIRETVVKILSCGPASSGQRWMFKNDGTILNLYSGLVLDVRASDPSLKQIILYPLHGDPNQIWLPLF,negative +GCGACUGGUUACCCGGUCG,MEPVDPRLEPWKHPGSQPKTACTNCYCKKCCFHCQVCFITKALGISYGRKKRRQRRRAHQNSQTHQASLSKQPTSQPRGDPTGPKE,negative +CAGGCGTTAGGGAAGGGCGTCGAAAGCAGGGTGGG,MDHLNEATQGKEHSEMSNNVSDPKGPPAKIARLEQNGSPLGRGRLGSTGAKMQGVPLKHSGHLMKTNLRKGTMLPVFCVVEHYENAIEYDCKEEHAEFVLVRKDMLFNQLIEMALLSLGYSHSSAAQAKGLIQVGKWNPVPLSYVTDAPDATVADMLQDVYHVVTLKIQLHSCPKLEDLPPEQWSHTTVRNALKDLLKDMNQSSLAKECPLSQSMISSIVNSTYYANVSAAKCQEFGRWYKHFKKTKDMMVEMDSLSELSQQGANHVNFGQQPVPGNTAEQPPSPAQLSHGSQPSVRTPLPNLHPGLVSTPISPQLVNQQLVMAQLLNQQYAVNRLLAQQSLNQQYLNHPPPVSRSMNKPLEQQVSTNTEVSSEIYQWVRDELKRAGISQAVFARVAFNRTQGLLSEILRKEEDPKTASQSLLVNLRAMQNFLQLPEAERDRIYQDERERSLNAASAMGPAPLISTPPSRPPQVKTATIATERNGKPENNTMNINASIYDEIQQEMKRAKVSQALFAKVAATKSQGWLCELLRWKEDPSPENRTLWENLSMIRRFLSLPQPERDAIYEQESNAVHHHGDRPPHIIHVPAEQIQQQQQQQQQQQQQQQAPPPPQPQQQPQTGPRLPPRQPTVASPAESDEENRQKTRPRTKISVEALGILQSFIQDVGLYPDEEAIQTLSAQLDLPKYTIIKFFQNQRYYLKHHGKLKDNSGLEVDVAEYKEEELLKDLEESVQDKNTNTLFSVKLEEELSVEGNTDINTDLKD,negative +GGGGGAGGACGCGTAGTGGGGGGCCCATGGTTGTGTGG,MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINYDEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQAVAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQGIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADMDFSALLSQISS,negative +GGATGATGCCGCACTGACGCCACGTAGGTGGCGCACAGCC,MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYTFLLPEMDNCRSSSSPYVSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQDNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVLVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF,negative +GGTTGGTTTGGTTGG,IMEIRTVAVGIVAIKGVESEYYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHSGGEMFVALNQKGLPVKGKKTKKEQKTAHFLPMAIT,negative +AAATGATTGCTACAATACATAGAGTCATGGAGATTACATC,PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKNSKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNRKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFYTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQK,negative +GGCTGTTGTGAGCCTCCTCCCAGAGGGAAGACTTTAGGTTCGGTTCACGTCCCGCTTATTCTTACTCCC,MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICEVEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASSIVYKKEGEQVEFSFPLAFTVEKLTGSGELWWQAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLPQALPQYAGSGNLTLALEAKTGKLHQEVNLVVMRATQLQKNLTCEVWGPTSPKLMLSLKLENKEAKVSKREKAVWVLNPEAGMWQCLLSDSGQVLLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQAERMSQIKRLLSEKKTCQCPHRFQKTCSPI,negative +CTTCTGCCCGCCTCCTTCCCTAGTCACTATTGTCTGGCGTGGGTAGGTGCCAATGGTAGGAGACGAGATAGGCGGACACT,MEPVDPRLEPWKHPGSQPKTACTNCYCKKCCFHCQVCFITKALGISYGRKKRRQRRRAHQNSQTHQASLSKQPTSQPRGDPTGPKE,negative +AGCCGCGAGGGGAGGGAUAGGGUAGGGCGCGGCU,PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGKISKIGPENPYNTPVFAIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDESFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPXRXKNPEMVIYQYMDDLYVGSDLEIGQHRAKIEELRSHLLSWGFTTPDKKHQKEPPFLWMGYELHPDSWTVQPIELPEKDSWTVNE,negative +CTCCTCTGACTGTAACCACGCAGCACCAGGAAGATGAATGCTCGAGCAACTCGACGGTCGGCATAGGTAGTCCAGAAGCC,QELLCAASLISDRWVLTAAHCLLYPPWDKNFTVNDILVRIGKYARSRYERNMEKISTLEKIIIHPGYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDKQIVTSLLQAGHKGRVTGWGNLKEMWTVNMNEVQPSVLQMVNLPLVERPICKASTGIRVTDNMFCAGYKPEEGKRGDACEGDSGGPFVMKNPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIRKMVDRFG,negative +AGCUUACAAAACCUGUAGUUUUAUGCUUCACAUAUCGCACAGGACGCGUUAAGCU,MSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEMLDRHHTHFCPLEGESWQDFLRNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAFLCQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERETPTTDSMPPLLRQAIELFDHQGAEPAFLFGLELIICGLEKQLKCESGS,negative +CCTAGTGTGCGTCGATGGGGTGGGGTGGGGCTGAGTTGGGGGGTGGGATCAATCAATCTGGTTT,MAWYWWRRRRRRGWWKPRRRRWRRRRARRRGPARRHRARRRIVRHPCNGQTSSGNRVPRSVQAVDPKYVSLQLVWHSWDFRRGLFGQAGIKRMQQESDALTLSPVHRPKRPKRDTQVKEKTPEKDSDSAVQLRRLQPWIHSSQETKDEEEEIPEGPVQEQLLQQLQQQRLLRVQLESIAQEVLKIRRGHSLHPLLSSHA,negative +GGACGCGUGGUACCAGGCCGAUCUAUGGACGCUAUAGGGACACCGGAUACUUUAACGAUUGGCUAAGCUUCCGCGGGGAUC,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,negative +GCTGGTCTCTGCGGGTTGTTGCGCCGCGGCACCCTTGGCA,MKRASAGGSRLLAWVLWLQAWQVAAPCPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDNPWVCDCRARPLWAWLQKFRGSSSEVPCSLPQRLAGRDLKRLAANDLQGCAVATGPYHPIWTGRATDEEPLGLPKCCQPDAADKASVLEPGRPASAGNALKGRVPPGDSPPGNGSGPRHINDSPFGTLPGSAEPPLTAVRPEGSEPPGFPTSGPRRRPGCSRKNRTRSHCRLGQAGSGGGGTGDSEGSGALPSLTCSLTPLGLALVLWTVLGPC,negative +ATACCAGCTTATTCAATTGACATGACTGGGATTTTTGGCGAAATCGAAGGAAGCGGAGAGATAGTAAGTGCAATCT,MASTSRLDALPRVTCPNHPDAILVEDYRAGDMICPECDRVIDVGSEWRTFSNDKATKDPSRVGDSQNPLLSDGDLSTMIGKGTGAASFDEFGNSKYQNRRTMSSSDRAMMNAFKEITTMADRINLPRNIVDRTNNLFKQVYEQKSLKGRANDAIASACLYIACRQEGVPRTFKEICAVSRISKKEIGRCFKLILKALETSVDLITTGDFMSRFCSNLCLPKQVQMAATHIA,negative +AGAGAGAAAGCCAACCATAGCAAATGATACGGAGATTTTG,MGVLLTQRTLLSLVLALLFPSMASMAAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQGLDVPKLREHCRERPGAFPSEETLRGLGRRGFLQTLNATLGCVLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILGLRNNIYCMAQLLDNSDTAEPTKAGRGASQPPTPTPASDAFQRKLEGCRFLHGYHRFMHSVGRVFSKWGESPNRSRRHSPHQALRKGVRRTRPSRKGKRLMTRGQLPR,negative +GTGATCGTCCAGCGACCGAGCAGGAAACTTATGTAACGACCCGAAATTCCTGCTTAGACT,MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYTFLLPEMDNCRSSSSPYVSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQDNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVLVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF,negative +AUCGUACAGAGGCAAGCAGAACGCGCGGU,MASTSRLDALPRVTCPNHPDAILVEDYRAGDMICPECDRVIDVGSEWRTFSNDKATKDPSRVGDSQNPLLSDGDLSTMIGKGTGAASFDEFGNSKYQNRRTMSSSDRAMMNAFKEITTMADRINLPRNIVDRTNNLFKQVYEQKSLKGRANDAIASACLYIACRQEGVPRTFKEICAVSRISKKEIGRCFKLILKALETSVDLITTGDFMSRFCSNLCLPKQVQMAATHIA,negative +CTAAGGATCGGATCCACGGCCTACCAGGTC,GLVKKAHEISVLCDAELALIIFSPKGKLYEYATDSKMEIILERYERYTYAEKALIASDPDVQGNWCHEYIKLKAKFEALNKSQRHLMGEQLDTLNQKELLQLETKLEGSLKNVRSRKTQLMLDSISELQEKGKSLQEQNTCLEKEILGKQKDKAPKQHVQWEKQNQPPPTSSAPMPFLIGDIHPTPNIRNFQGRTVADA,negative +CTTGCAAAATTTGCAACTGTGTG,XQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGSTGSPGPGYGYSNYGFPPYGGITFHPGVTKSNAGVTHGTINTKFKNGPKDCAKSDDEESLTLPEKETEGEGPSLPMACTKTEPIALASTMEDKEQDMGFQDNLFLEKALQLARRHANALFDYAVTGDVKMLLAVQRHLTAVQDENGDSVLHLAIIHLHAQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRVGADLSLLDRWGNSVLHLAAKEGHDRILSILLKSRKAAPLIDHPNGEGLNAIHIAVMSNSLPCLLLLVAAGAEVNAQEQKSGRTALHLAVEYDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWEKAGEDEGVVPGTTPLDMAANWQVFDILNGKPYEPVFTSDDILPQGDMKQLTEDTRLQLCKLLEIPDPDKNWATLAQKLGLGILNNAFRLSPAPSKTLMDNYEMNSGIVTASVTVVWRHPSANSALQSLLLETAHCYL,negative +TCCCACGCATTCTCCACATCTAGTCTGGTTACGGTCTCGATTGTCCCAAAAGGGCAGACACCTTTCTGTCCTTCCGTCAC,MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA,negative +CTCCTCTGACTGTAACCACGCCCATATCGGTGAATGCACGAGCAACCGATTGACACGGGGCATAGGTAGTCCAGAAGCC,GLVKKAHEISVLCDAELALIIFSPKGKLYEYATDSKMEIILERYERYTYAEKALIASDPDVQGNWCHEYIKLKAKFEALNKSQRHLMGEQLDTLNQKELLQLETKLEGSLKNVRSRKTQLMLDSISELQEKGKSLQEQNTCLEKEILGKQKDKAPKQHVQWEKQNQPPPTSSAPMPFLIGDIHPTPNIRNFQGRTVADA,negative +CTTCTGCCCGCCTCCTTCCGTTTGATCAAGCTGGTTTGGACTTTCGGAGACGAGATAGGCGGACACT,MKKRKVLIPLMALSTILVSSTGNLEVIQAEVKQENRLLNESESSSQGLLGYYFSDLNFQAPMVVTSSTTGDLSIPSSELENIPSENQYFQSAIWSGFIKVKKSDEYTFATSADNHVTMWVDDQEVINKASNSNKIRLEKGRLYQIKIQYQRENPTEKGLDFKLYWTDSQNKKEVISSDNLQLPELKQKSSNSRKKRSTSAGPTVPDRDNDGIPDSLEVEGYTVDVKNKRTFLSPWISNIHEKKGLTKYKSSPEKWSTASDPYSDFEKVTGRIDKNVSPEARHPLVAAYPIVHVDMENIILSKNEDQSTQNTDSQTRTISKNTSTSRTHTSEVHGNAEVHASFFDIGGSVSAGFSNSNSSTVAIDHSLSLAGERTWAETMGLNTADTARLNANIRYVNTGTAPIYNVLPTTSLVLGKNQTLATIKAKENQLSQILAPNNYYPSKNLAPIALNAQDDFSSTPITMNYNQFLELEKTKQLRLDTDQVYGNIATYNFENGRVRVDTGSNWSEVLPQIQETTARIIFNGKDLNLVERRIAAVNPSDPLETTKPDMTLKEALKIAFGFNEPNGNLQYQGKDITEFDFNFDQQTSQNIKNQLAELNATNIYTVLDKIKLNAKMNILIRDKRFHYDRNNIAVGADESVVKEAHREVINSSTEGLLLNIDKDIRKILSGYIVEIEDTEGLKEVINDRYDMLNISSLRQDGKTFIDFKKYNDKLPLYISNPNYKVNVYAVTKENTIINPSENGDTSTNGIKKILIFSKKGYEIG,negative +CCTTCGTTGTCTGCCTTCGTTAATCGGCTCGATTGATTCGAGGTGACGGTCGTTGGACGTGACGTTACGCACCCTTCAGAATTCGCACCA,MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYTFLLPEMDNCRSSSSPYVSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQDNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVLVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF,negative +GGGAGAAUUCAACUGCCAUCUAGGCGCUAGUAGCCUCAGCAGCAUAGUUUCGCCGCUAUGCAGUAAGUACUACAAGCUUCUGGACUCGGU,MAMQMQLEANADTSVEEESFGPQPISRLEQCGINANDVKKLEEAGFHTVEAVAYAPKKELINIKGISEAKADKILAEAAKLVPMGFTTATEFHQRRSEIIQITTGSKELDKLLQGGIETGSITEMFGEFRTGKTQICHTLAVTCQLPIDRGGGEGKAMYIDTEGTFRPERLLAVAERYGLSGSDVLDNVAYARAFNTDHQTQLLYQASAMMVESRYALLIVDSATALYRTDYSGRGELSARQMHLARFLRMLLRLADEFGVAVVITNQVVAQVDGAAMFAADPKKPIGGNIIAHASTTRLYLRKGRGETRICKIYDSPCLPEAEAMFAINADGVGDAKD,negative +GGCGATAGTTTCTATAGCAAGGTACAGCATTCTCTCTCCCTATAGAACCAATCCAGTACTAGC,MAKGEFIRTKPHVNVGTIGHVDHGKTTLTAALTYVAAAENPNVEVKDYGDIDKAPEERARGITINTAHVEYETAKRHYSHVDCPGHADYIKNMITGAAQMDGAILVVSAADGPMPQTREHILLARQVGVPYIVVFMNKVDMVDDPELLDLVEMEVRDLLNQYEFPGDEVPVIRGSALLALEEMHKNPKTKRGENEWVDKIWELLDAIDEYIPTPVRDVDKPFLMPVEDVFTITGRGTVATGRIERGKVKVGDEVEIVGLAPETRKTVVTGVEMHRKTLQEGIAGDNVGLLLRGVSREEVERGQVLAKPGSITPHTKFEASVYILKKEEGGRHTGFFTGYRPQFYFRTTDVTGVVRLPQGVEMVMPGDNVTFTVELIKPVALEEGLRFAIREGGRTVGAGVVTKILE,negative +UUCCAUUGGAGUGGAACUGAGUUC,MANLGYWLLALFVTMWTDVGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGTWGQPHGGGWGQPHGGSWGQPHGGSWGQPHGGGWGQGGGTHNQWNKPSKPKTNLKHVAGAAAAGAVVGGLGGYMLGSAMSRPMIHFGNDWEDRYYRENMYRYPNQVYYRPVDQYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCVTQYQKESQAYYDGRRSSSTVLFSSPPVILLISFLIFLIVG,negative +GGACCUUUGUACCCCAGAUGACGGCUCAUUUCGUGCUUGAUGGGUACAAAUGGCAG,VENLMVQELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFSHFRLFDENNDAAILILLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVN,negative +TCCCTACGGCGCTAACTTCTGCAAGAGGCCGTCAACGGGCGAGTTAGCCACCGTGCTACAAC,VFTDNSSPPAVPQSFQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGFGAYMSKAHGVDPNIRTGVRTITTGSPITYSTYGKFLADGGCSGGAYDIIICDECHSTDATSILGIGTVLDQAETAGARLVVLATATPPGSVTVSHPNIEEVALSTTGEIPFYGKAIPLEVIKGGRHLIFCHSKKKCDELAAKLVALGINAVAYYRGLDVSVIPTSGDVVVVSTDALMTGFTGDFDSVIDCNTCVTQTVDFSLDPTFTIETTTLPQDAVSRTQRRGRTGRGKPGIYRFVAPGERPSGMFDSSVLCECYDAGCAWYELTPAETTVRLRAYMNTPGLPVCQDHLEFWEGVFTGLTHIDAHFLSQTKQSGENFPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPTLHGPTPLLYRLGAVQNEVT,negative +TTGGGGTGGGAGGGCGGGTTAACAAAGATAGCGCAACAGG,MASNFTQFVLVDNGGTGDVTVAPSNFANGVAEWISSNSRSQAYKVTCSVRQSSAQNRKYTIKVEVPKVATQTVGGVELPVAAWRSYLNMELTIPIFATNSDCELIVKAMQGLLKDGNPIPSAIAANSGIY,negative +CTTCTGCCCGCCTCCTTCCGACTGTTGGTTCTTGGGAGGAGTGCGGACTTTGCCACGCGGAGACGAGATAGGCGGACACT,MVMGLGVLLLVFVLGLGLTPPTLAQDNSRYTHFLTQHYDAKPQGRDDRYCESIMRRRGLTSPCKDINTFIHGNKRSIKAICENKNGNPHRENLRISKSSFQVTTCKLHGGSPWPPCQYRATAGFRNVVVACENGLPVHLDQSIFRRP,negative +UUAGCACAAACAACCCCAGAAGUGCAACGC,MSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEMLDRHHTHFCPLEGESWQDFLRNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAFLCQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERETPTTDSMPPLLRQAIELFDHQGAEPAFLFGLELIICGLEKQLKCESGS,negative +AGCAGCACAGAGGTCAGATGAAGCGATTGTAATCAACGCCGTAAGACCTCGAGTCGATTTCCTATGCGTGCTACCGTGAA,MSMSPKHTTPFSVSDILSPLEESYKKVGMEGGGLGAPLAAYRQGQAAPPAAAMQQHAVGHHGAVTAAYHMTAAGVPQLSHSAVGGYCNGNLGNMSELPPYQDTMRNSASGPGWYGANPDPRFPAISRFMGPASGMNMSGMGGLGSLGDVSKNMAPLPSAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGGGGGGGAGCPQQQQAQQQSPRRVAVPVLVKDGKPCQAGAPAPGAGSLQGHAQQQAQQQAQAAQAAAAAISVGSGGPGLGAHPGHQPGSAGQSPDLAHHAASPAALQGQVSSLSHLNSSGSDYGTMSCSTLLYGRTW,negative +TTGGGGAGGGGCACTGGGCAGTGTAATTTACGAAAGCGAG,MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICEVEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASSIVYKKEGEQVEFSFPLAFTVEKLTGSGELWWQAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLPQALPQYAGSGNLTLALEAKTGKLHQEVNLVVMRATQLQKNLTCEVWGPTSPKLMLSLKLENKEAKVSKREKAVWVLNPEAGMWQCLLSDSGQVLLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQAERMSQIKRLLSEKKTCQCPHRFQKTCSPI,negative +ATTTGCAACACTTACCACTAAAAGGGCCGACGACCGATGATGTTAGGTCCAGTGCTTTCT,MASNFTQFVLVDNGGTGDVTVAPSNFANGVAEWISSNSRSQAYKVTCSVRQSSAQNRKYTIKVEVPKVATQTVGGVELPVAAWRSYLNMELTIPIFATNSDCELIVKAMQGLLKDGNPIPSAIAANSGIY,negative +CAGCTCAGAAGCTTGATCCTGTGCGGGGCAAAGAGGTCCGAATTTGAAGGCTCCCCTGGACTCGAAGTCGTGCATCTGCA,AKTALQVPLPHPMQMNALGGYSPASTCNGYGRMGLHQEKLPSDLDGMFIERLDCDMESIIRNDLMDGDTLDFNFDNVLPNQSFPHSVKTTTHSWVSG,negative +CGTTCGAAATTCGAACCTGTGTG,MDSTNYISKLFEYAQRQGQISDIKFEEVGTDGPDHLKTFTLRVVIKGHAYPNGVGKTKKEAKRNAAKHALIGMMETTEQKDASVSCPPSPAPSPAPPVRAVISQPKYVSWLNEHSQKNKLSLKALEGARVGPNNTSQCCRYVVGEKEYPEGFGNTKKEAKEEAAMQVYLELCGGSQTTGTVDENCNGTTGKHKEELNGKVVVLSEKVEHMNMSPAQNVPEQYSFITTEETNFIGILNHYCQKTKRFLDFKLVEKSGPSHNPQFVYKVLIDKREYPDGLGKTAKEAKQQAAQLAWSALQEQSDWNSQVSCRSTVSEEGGLSSLTPSSTWESQDATPSSLSIAGSTSESIIFSDSVNVSSPKDESPVNVKPKIRLAANFQMSPVKTKQEGPNLKGNDLGTLSSGRTSNQPVISRFSSEFDSIENIGKGGFGHVYKARRKLEQKYFAVKIVRSKGKAKREVGALADLQHPNIVRYYTAWLEDTAYRCDTASESDTTSDSGSSSSSEFLYIQMELCDKRTLKVWIDERNAHRKPKRREESLSITQQIVNGVEYIHSKKLLHRDLKPANIMFGMSDGEGKGEVKIGDFGLVTAEDNDNDENLLERTKKTGTVSYMAPEQRNQTSYDRKVDIFALGLIYFEPLWDLSGMEKAKVWNDVRSQRFPQQFNSQFTLENKVIESLLCANPEERPDARQLKTKLNECSRVLTRVHNIHQDNRTI,negative +ACGAAACCUGCAGUCCUGCAAUGGGACAAG,MAKGEFIRTKPHVNVGTIGHVDHGKTTLTAALTYVAAAENPNVEVKDYGDIDKAPEERARGITINTAHVEYETAKRHYSHVDCPGHADYIKNMITGAAQMDGAILVVSAADGPMPQTREHILLARQVGVPYIVVFMNKVDMVDDPELLDLVEMEVRDLLNQYEFPGDEVPVIRGSALLALEEMHKNPKTKRGENEWVDKIWELLDAIDEYIPTPVRDVDKPFLMPVEDVFTITGRGTVATGRIERGKVKVGDEVEIVGLAPETRKTVVTGVEMHRKTLQEGIAGDNVGLLLRGVSREEVERGQVLAKPGSITPHTKFEASVYILKKEEGGRHTGFFTGYRPQFYFRTTDVTGVVRLPQGVEMVMPGDNVTFTVELIKPVALEEGLRFAIREGGRTVGAGVVTKILE,negative +GCAAUGACCAAGGUACCGACCCUAUGGCUCCGGCCUGCGU,MAGPQALAFGLLLAVVTATLAAAQRDCVCDNYKLATSCSLNEYGECQCTSYGTQNTVICSKLASKCLAMKAEMTHSKSGRRIKPEGAIQNNDGLYDPDCDEQGLFKAKQCNGTATCWCVNTAGVRRTDKDTEITCSERVRTYWIIIELKHKERESPYDHQSLQTALQEAFTSRYKLNQKFIKNIMYENNVITIDLMQNSSQKTQDDVDIADVAYYFEKDVKGESLFHSSKSMDLRVNGEPLDLDPGQTLIYYVDEKAPEFSMQGLTAGIIAVIVVVSLAVIAGIVVLVISTRKKSAKYEKAEIKEMGEIHRELNA,negative +TATTAGCAATAATATTAGCAATAA,MVKSHIGSWILVLFVAMWSDVGLCKKRPKPGGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGTHGQWNKPSKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGSDYEDRYYRENMHRYPNQVYYRPVDQYSNQNNFVHDCVNITVKEHTVTTTTKGENFTETDIKMMERVVEQMCITQYQRESQAYYQRGASVILFSSPPVILLISFLIFLIVG,negative +TATTAGTCATAATATTAGTCATAA,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +ATACCAGTCTATTCAATTGGGCCCGTCCGTATGGTGGGTGTGCTGGCCAGATAGTATGTGCAATCA,MAITKINDCFELLSMVTYADKLKSLIKKEFSISFEEFAVLTYISENKEKEYYLKDIINHLNYKQPQVVKAVKILSQEDYFDKKRNEHDERTVLILVNAQQRKKIESLLSRVNKRITEANNEIEL,negative +TTGGGGTGGGAGGGCGGGTTAACAAAGATAGCGCAACAGG,MAIPKELLVLLLGIAILSKVAECAAFGSRRGLVETVFDVTRFGARPNTPADSTRGLMMAWRSACQSPGPAKVVIPPGTYTTGETIFQGPCTSPRPITIEIQGTLLSNTDMSLYTRAAWISIEHVDGIVITGGGTLNGQGKSSWQFADKSGSTPPLPSSLVFQTVRSSSIKNLNFVDAKGVHLKITDSSDISVSNIKITAPGDSPNTDGLHISDTINVNVTDSTIGTGDDCISIGDGNSNVYISNINCGPGHGISIGSLGKRLDETDVKGVTVRNCTFRGTTNGARIKTYMGSPSLQVSGVVYEDIILDNVKNPIVIDQHYHSKNRNEPSRVKLVDIHFRNIRGTTTSKIPVLLNCSEALPCEGVELVDIDLAPVGSIGPLLPATCQNAKTILNGKNNPPAC,negative +GGGUUACCUAGGUGUAGAUGCUCUUCAGAUUCAUUUAUAAGAUCCGACAACCUGUCUAUUAGUUGCGCCGAUUAAGUGACGUCUGAACUGCUUCGAA,MKPGGNTIVIWMYAVATWLCFGSTSGWSFTLEDNNIFPKQYPIINFTTAGATVQSYTNFIRAVRGRLTTGADVRHEIPVLPNRVGLPINQRFILVELSNHAELSVTLALDVTNAYVVGYRAGNSAYFFHPDNQEDAEAITHLFTDVQNRYTFAFGGNYDRLEQLAGNLRENIELGNGPLEEAISALYYYSTGGTQLPTLARSFIICIQMISEAARFQYIEGEMRTRIRYNRRSAPDPSVITLENSWGRLSTAIQESNQGAFASPIQLQRRNGSKFSVYDVSILIPIIALMVYRCAPPPSSQFSLLIRPVVPNFNADVCMDPEPIVRIVGRNGLCVDVRDGRFHNGNAIQLWPCKSNTDANQLWTLKRDNTIRSNGKCLTTYGYSPGVYVMIYDCNTAATDATRWQIWDNGTIINPRSSLVLAATSGNSGTTLTVQTNIYAVSQGWLPTNNTQPFVTTIVGLYGLCLQANSGQVWIEDCSSEKAEQQWALYADGSIRPQQNRDNCLTSDSNIRETVVKILSCGPASSGQRWMFKNDGTILNLYSGLVLDVRASDPSLKQIILYPLHGDPNQIWLPLF,negative +UGAUGGUAUUGGAGCCACCUAAAGGGACGUUUUCGG,MSSSQKKAGGKAGKPTKRSQNYAALRKAQLPKPPALKVPVVKPTNTILPQTGCVWQSLGTPLSLSSFNGLGARFLYSFLKDFVGPRILEEDLIYRMVFSITPSHAGTFCLTDDVTTEDGRAVAHGNPMQEFPHGAFHANEKFGFELVFTAPTHAGMQNQNFKHSYAVALCLDFDAQPEGSKNPSFRFNEVWVERKAFPRAGPLRSLITVGLFDEADDLDRH,negative +ACUCACCAGUCACCAUCAGCUCAUGCGCCCCUCCCCCGAC,MAVAQELYGFPASKLDSFVAQWLQPTREWKEEVLETVQTVEQFLRQENFREDRGPARDVRVLKVLKVGCFGNGTVLRSTTDVELVVFLSCFHSFQEEAKHHQAVLRLIQKRMYYCQELMDLGLSNLSVTNRVPSSLIFTIQTRETWETITVTVVPAYRALGPSCPSSEVYANLIKANGYPGNFSPSFSELQRNFVKHRPTKLKSLLRLVKHWYQQYVRDKCPRANLPPLYALELLTVYAWEAGTREDANFRLDEGLATVMELLQDHELLCIYWTKHYTLQHPVIEACVRRQLRGQRPIILDPADPTNNVAEGYRWDIVAQRANQCLKQDCCYDNRDSPVPSWRVKRAPDIQVTVQEWGHSDLTFWVNPYEPIKKLKEKIQLSQGYLGLQRLSFQEPGGERQLIRSHCTLAYYGIFCDTHICLLDTISPEIQVFVKNPDGRSHAYAIHPLDYVLNLKQQIEDRQGLRCQEQRLEFQGHILEDWFDFKSYGIQDSVTVILSKTTEGAAPFVPS,negative +GGGAAUGGAUCCACAUCUACGAAUUCAGGGGACGUAGCAAUGACUGAGAUGCUGGGUUCACUGCAGACUUGACGAAGCUU,ASFTCLAIWALASAGVVPLVLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAAFFFVPVIISTVCYVSIIRCLSSSAVANRSKK,negative +GAGGACGAUGCGGACUAGCCUCAUCAGCUCAUGUGCCCCUC,MQRTKEAVKASDGNLLGDPGRIPLSKRESIKWQRPRFTRQALMRCCLIKWILSSAAPQGSDSSDSELELSTVRHQPEGLDQLQAQTKFTKKELQSLYRGFKNECPTGLVDEDTFKLIYSQFFPQGDATTYAHFLFNAFDADGNGAIHFEDFVVGLSILLRGTVHEKLKWAFNLYDINKDGCITKEEMLAIMKSIYDMMGRHTYPILREDAPLEHVERFFQKMDRNQDGVVTIDEFLETCQKDENIMNSMQLFENVI,negative +CTTCTGCCCGCCTCCTTCCGTTTTCCTGCGGCAGCGTTTTGTTGCTTTCGTTCCTCCGGGAGACGAGATAGGCGGACACT,XQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGSTGSPGPGYGYSNYGFPPYGGITFHPGVTKSNAGVTHGTINTKFKNGPKDCAKSDDEESLTLPEKETEGEGPSLPMACTKTEPIALASTMEDKEQDMGFQDNLFLEKALQLARRHANALFDYAVTGDVKMLLAVQRHLTAVQDENGDSVLHLAIIHLHAQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRVGADLSLLDRWGNSVLHLAAKEGHDRILSILLKSRKAAPLIDHPNGEGLNAIHIAVMSNSLPCLLLLVAAGAEVNAQEQKSGRTALHLAVEYDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWEKAGEDEGVVPGTTPLDMAANWQVFDILNGKPYEPVFTSDDILPQGDMKQLTEDTRLQLCKLLEIPDPDKNWATLAQKLGLGILNNAFRLSPAPSKTLMDNYEMNSGIVTASVTVVWRHPSANSALQSLLLETAHCYL,negative +CGGGGTGTTGTCCTGTGCTCTCCGGAGAGCACAGGACAACACCCCG,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +AACAUAUCCCCAGCCAUGCAACGUGGCGAA,MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYTFLLPEMDNCRSSSSPYVSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQDNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVLVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF,negative +CGACGCACCGATCGCAGGTTCGGGA,MNRPHSCLSFCWMYFAASGIRAVETANGKYAQKLFSDLFEDYSSALRPVEDTDAVLNVTLQVTLSQIKDMDERNQILTAYLWIRQTWHDAYLTWDRDQYDRLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDSPAITKSSCVVDVTYFPFDSQQCNLTFGSWTYNGNQVDIFNALDSGDLSDFIEDVEWEVHGMPAVKNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGEKVSLGVTILLAMTVFQLMVAEIMPASENVPLIGKYYIATMALITASTALTIMVMNIHFCGAEARPVPHWAKVVILKYMSRILFVYDVGESCLSPRHSQEPEQVTKVYSKLPESNLKTSRNKDLSRKKEVRKLLKNDLGYQGGIPQNTDSYCARYEALTKNIEYIAKCLKDHKATNSKGSEWKKVAKVIDRFFMWIFFAMVFVMTVLIIARAD,negative +AATTTCTACTGCAATTTCTACTGC,IMEIRTVAVGIVAIKGVESEYYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHSGGEMFVALNQKGLPVKGKKTKKEQKTAHFLPMAIT,negative +ACCCCTCTTACCCGAAGCGTTAAGCGGTGGAGGCTGTCA,MTPDIQAPFLSLLLLFPVLTVANVPTLTTSDSINPRRTTPVSTTQSSPTSSPTKETSWSTTTTLLTASSPAPSPAASPGHDGASTPTSSPAPSPAASPGHDGASTPTSSPAPSPAASPGHDGASTPTSSPAPSPAASPGHDGASTPTSSPAPSPAASPGHNGTSSPTGSPAPSPAASPGHDGASTPTSSPAPSPAASPGHNGTSSPTGSPAPSPAASPGHDGASTPTSSPAPSPAASPGHNGTSSPTGSPAPSPTASPGHDSAPSLTSSPAPSPTASPGQHGASSPTSSDTSSMTTRSMSSSMVTSAHKGTSSRATMTPVSKGTPSSVPSSETAPTAASHITRTAASSPSIALSTSSNPKTSQQLSVRVSLYFLSFRITNLQFNSSLENPQTSYYQELQRSIWGLILQIYKQRDFLGLSEIKFRPGSVVVELTLAFREGTTAEWVKAQFSQLEAHAASYNLTISGVSVYSAPFPSSAQAGSGVPGWGIALLVLVCVLVALAIIYLIALVVCQCGRKKCEQLDVFPTLDAYHPMSEYSTYHTHGRYVPPGSTKRSPYEEVSAGNGGSNLSYTNLAATSANL,negative +CAGGAAACAGCAAGACAAACGAUGGGGAGCGUAAGACUGCGAGUGUCGGA,PHITDVVLDKANKTPLRQLDPSRLPDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFAKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRQSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPINRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDTASEATRPATLNRFSALQQTLPAENTDNRRVVQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRTRTPATKRSFSKEVEERSRERPSQPEGLRKAASLTEDRGRDPVKREATLPPVSPPKAALSVDEVEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRLGIESTLERSTIAREHMGRLLHQLLCAGHLSTAQYYQGLYETLELAEDMEIDIPHVWLYLAELITPILQEDGVPMGELFREITKPLRPMGKATSLLLEILGLLCKSMGPKKVGMLWREAGLSWREFLAEGQDVGSFVAEKKVEYTLGEESEAPGQRTLAFEELRRQLEKLLKDGGSNQRVFDWIDANLNEQQIASNTLVRALMTTVCYSAIIFETPLRVDVQVLKVRARLLQKYLCDEQKELQALYALQALVVTLEQPANLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFNWLREAEDEESDHN,negative +AAUAACUU,MVKSHIGSWILVLFVAMWSDVGLCKKRPKPGGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGTHGQWNKPSKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGSDYEDRYYRENMHRYPNQVYYRPVDQYSNQNNFVHDCVNITVKEHTVTTTTKGENFTETDIKMMERVVEQMCITQYQRESQAYYQRGASVILFSSPPVILLISFLIFLIVG,negative +CTTCTGCCCGCCTCCTTCCTTCTTGAATTTTGAGATGAGGTCACTAGGTCCTTCGCGGGGAGACGAGATAGGCGGACACT,MASNFTQFVLVDNGGTGDVTVAPSNFANGVAEWISSNSRSQAYKVTCSVRQSSAQNRKYTIKVEVPKVATQTVGGVELPVAAWRSYLNMELTIPIFATNSDCELIVKAMQGLLKDGNPIPSAIAANSGIY,negative +GCATGAATTCCCGAAGACGCAAACTGAAGAGGCACCGAAGGGGGGG,MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA,negative +UAUGAUGGUAGACGCCGUACCGCAUCAGGCCAAGUCGUCACAGAUCGUG,QELLCAASLISDRWVLTAAHCLLYPPWDKNFTVNDILVRIGKYARSRYERNMEKISTLEKIIIHPGYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDKQIVTSLLQAGHKGRVTGWGNLKEMWTVNMNEVQPSVLQMVNLPLVERPICKASTGIRVTDNMFCAGYKPEEGKRGDACEGDSGGPFVMKNPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIRKMVDRFG,negative +UUUGGUUAUCAUGUUUAUGCGUACGGGCGCCCAU,MTPDIQAPFLSLLLLFPVLTVANVPTLTTSDSINPRRTTPVSTTQSSPTSSPTKETSWSTTTTLLTASSPAPSPAASPGHDGASTPTSSPAPSPAASPGHDGASTPTSSPAPSPAASPGHDGASTPTSSPAPSPAASPGHDGASTPTSSPAPSPAASPGHNGTSSPTGSPAPSPAASPGHDGASTPTSSPAPSPAASPGHNGTSSPTGSPAPSPAASPGHDGASTPTSSPAPSPAASPGHNGTSSPTGSPAPSPTASPGHDSAPSLTSSPAPSPTASPGQHGASSPTSSDTSSMTTRSMSSSMVTSAHKGTSSRATMTPVSKGTPSSVPSSETAPTAASHITRTAASSPSIALSTSSNPKTSQQLSVRVSLYFLSFRITNLQFNSSLENPQTSYYQELQRSIWGLILQIYKQRDFLGLSEIKFRPGSVVVELTLAFREGTTAEWVKAQFSQLEAHAASYNLTISGVSVYSAPFPSSAQAGSGVPGWGIALLVLVCVLVALAIIYLIALVVCQCGRKKCEQLDVFPTLDAYHPMSEYSTYHTHGRYVPPGSTKRSPYEEVSAGNGGSNLSYTNLAATSANL,negative +AUUUCUCUGAGAUGUUCGCAAGCGGGCCAGUCCCCUGAGCCGAUAUUUCAUACCACAAGAAAUGUGGCGCUCCGCGGUUGGUGAGCAUGCUCGGUCCGUCCGAGAAGCCUUAAAACUGCGACGACACAUUCACCUUGAACCAAGGGUUCAAGGGUUACAGCCUGCGGCGGCAUCUCGGAGAUUCC,IMEIRTVAVGIVAIKGVESEYYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHSGGEMFVALNQKGLPVKGKKTKKEQKTAHFLPMAIT,negative +GGGAGAAGGGAAGTAACAGGUUUCGUGCCUUUUCUCGAUGGAGUGAGAAGAGGTGACGGTACCAG,MAGRSGDSDEELLKAVRLIKFLYQSNPPPNPEGTRQARRNRRRRWRERQRQIHSISERILSTYLGRSAEPVPLQLPPLERLTLDCNEDCGTSGTQGVGSPQILVESPTILESGAKE,negative +CATCTCGGTCGTGAACTTTACATGCATGAGTATTTTGGTG,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,negative +GGTTGGTGTGGTTGG,MDKLVVNYYEYKHPIINKDLAIGAHGGKKFPTLGAWYDVINEYEFQTRCPIILKNSHRNKHFTFACHLKNCPFKVLLSYAGNAASSETSSPSANNNTNPPGTPDHIHHHSNNMNNEDNDNNNGSNNKVSNDSKLDFVTDDLEYHLANTHPDDTNDKVESRSNEVNGNNDDDADANNIFKQQGVTIKNDTEDDSINKASIDRGLDDESGPTHGNDSGNHRHNEEDDVHTQMTKNYSDVVNDEDINVAIANAVANVDSQSNNKHDGKDDDATNNNDGQDNNTNNDHNNNSNINNNNVGSHGISSHSPSSIRDTSMNLDVFNSATDDIPGPFVVTKIEPYHSHPLEDNLSLGKFILTKIPKILQNDLKFDQILESSYNNSNHTVSKFKVSHYVEESGLLDILMQRYGLTAEDFEKRLLSQIARRITTYKARFVLKKKKMGEYNDLQPSSSSNNNNNNDGELSGTNLRSNSIDYAKHQEISSAGTSSNTTKNVNNNKNDSNDDNNGNNNNDASNLMESVLDKTSSHRYQPKKMPSVNKWSKPDQITHSDVSMVGLDESNDGGNENVHPTLAEVDAQEARETAQLAIDKINSYKRSIDDKNGDGHNNSSRNVVDENLINDMDSEDAHKSKRQHLSDITLEERNEDDKLPHEVAEQLRLLSSHLKEVENLHQNNDDDVDDVMVDVDVESQYNKNTTHHNNHHSQPHHDEEDVAGLIGKADDEEDLSDENIQPELRGQ,negative +CACGATGGTTAGGCGGGCCTTGAGGCTAATAATGTTGTTA,MTSHYVIAIFALMSSCLATAGPEPGALCELSPVSASHPVQALMESFTVLSGCASRGTTGLPQEVHVLNLRTAGQGPGQLQREVTLHLNPISSVHIHHKSVVFLLNSPHPLVWHLKTERLATGVSRLFLVSEGSVVQFSSANFSLTAETEERNFPHGNEHLLNWARKEYGAVTSFTELKIARNIYIKVGEDQVFPPKCNIGKNFLSLNYLAEYLQPKAAEGCVMSSQPQNEEVHIIELITPNSNPYSAFQVDITIDIRPSQEDLEVVKNLILILKCKKSVNWVIKSFDVKGSLKIIAPNSIGFGKESERSMTMTKSIRDDIPSTQGNLVKWALDNGYSPITSYTMAPVANRFHLRLENNAEEMGDEEVHTIPPELRILLDPGALPALQNPPIRGGEGQNGGLPFPFPDISRRVWNEEGEDGLPRPKDPVIPSIQLFPGLREPEEVQGSVDIALSVKCDNEKMIVAVEKDSFQASGYSGMDVTLLDPTCKAKMNGTHFVLESPLNGCGTRPRWSALDGVVYYNSIVIQVPALGDSSGWPDGYEDLESGDNGFPGDMDEGDASLFTRPEIVVFNCSLQQVRNPSSFQEQPHGNITFNMELYNTDLFLVPSQGVFSVPENGHVYVEVSVTKAEQELGFAIQTCFISPYSNPDRMSHYTIIENICPKDESVKFYSPKRVHFPIPQADMDKKRFSFVFKPVFNTSLLFLQCELTLCTKMEKHPQKLPKCVPPDEACTSLDASIIWAMMQNKKTFTKPLAVIHHEAESKEKGPSMKEPNPISPPIFHGLDTLTVMGIAFAAFVIGALLTGALWYIYSHTGETAGRQQVPTSPPASENSSAAHSIGSTQSTPCSSSSTA,negative +AGAGUCGCUGAUGGUAGACGCCGGCGGAUC,MSMSPKHTTPFSVSDILSPLEESYKKVGMEGGGLGAPLAAYRQGQAAPPAAAMQQHAVGHHGAVTAAYHMTAAGVPQLSHSAVGGYCNGNLGNMSELPPYQDTMRNSASGPGWYGANPDPRFPAISRFMGPASGMNMSGMGGLGSLGDVSKNMAPLPSAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGGGGGGGAGCPQQQQAQQQSPRRVAVPVLVKDGKPCQAGAPAPGAGSLQGHAQQQAQQQAQAAQAAAAAISVGSGGPGLGAHPGHQPGSAGQSPDLAHHAASPAALQGQVSSLSHLNSSGSDYGTMSCSTLLYGRTW,negative +TGCCTTGTTATTGTGGTGGGCGGGTGGGAC,MEYASDASLDPEAPWPPAPRARACRVLPWALVAGLLLLLLLAAACAVFLACPWAVSGARASPGSAASPRLREGPELSPDDPAGLLDLRQGMFAQLVAQNVLLIDGPLSWYSDPGLAGVSLTGGLSYKEDTKELVVAKAGVYYVFFQLELRRVVAGEGSGSVSLALHLQPLRSAAGAAALALTVDLPPASSEARNSAFGFQGRLLHLSAGQRLGVHLHTEARARHAWQLTQGATVLGLFRVTPEIPAGLPSPRSE,negative +GAAUCAACACACAGUCCUGGGGGCGUAACCAUGAACACCCAAGGCCUUAGUGGUAUGUGGUUCUUG,PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGKISKIGPENPYNTPVFAIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDESFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPXRXKNPEMVIYQYMDDLYVGSDLEIGQHRAKIEELRSHLLSWGFTTPDKKHQKEPPFLWMGYELHPDSWTVQPIELPEKDSWTVNE,negative +CUCAGAGACAGAGCAGAAACGACAGUUCAAGCCGAA,VVIRSNNFTDNAKTIIVQLNESIAINCTRPNNNTRKSIHIGPGRAFYTTGDIIGNIRQAHCNLSRTKWENTLKQIAKKLREQFGNKTIVFNH,negative +GCGCAGGCGGGGTTTGACTTCGAGGCCG,MTPDIQAPFLSLLLLFPVLTVANVPTLTTSDSINPRRTTPVSTTQSSPTSSPTKETSWSTTTTLLTASSPAPSPAASPGHDGASTPTSSPAPSPAASPGHDGASTPTSSPAPSPAASPGHDGASTPTSSPAPSPAASPGHDGASTPTSSPAPSPAASPGHNGTSSPTGSPAPSPAASPGHDGASTPTSSPAPSPAASPGHNGTSSPTGSPAPSPAASPGHDGASTPTSSPAPSPAASPGHNGTSSPTGSPAPSPTASPGHDSAPSLTSSPAPSPTASPGQHGASSPTSSDTSSMTTRSMSSSMVTSAHKGTSSRATMTPVSKGTPSSVPSSETAPTAASHITRTAASSPSIALSTSSNPKTSQQLSVRVSLYFLSFRITNLQFNSSLENPQTSYYQELQRSIWGLILQIYKQRDFLGLSEIKFRPGSVVVELTLAFREGTTAEWVKAQFSQLEAHAASYNLTISGVSVYSAPFPSSAQAGSGVPGWGIALLVLVCVLVALAIIYLIALVVCQCGRKKCEQLDVFPTLDAYHPMSEYSTYHTHGRYVPPGSTKRSPYEEVSAGNGGSNLSYTNLAATSANL,negative +GGGCUAGCUGAUCGUACCCAUAGCGUGGGCAUGGGGUGCCUAGUCGGGCGAUACUAACAGCUAACACCC,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,negative +CCGTAGGTTCGGGGTCGGAGTGGTCCGGAAGATGGCGTGG,MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH,negative +GGTTGTGAAGATTGGGAGCGTCGTGGCTAC,MSDLANSEKYYDEDPYGFEDESAPITAEDSWAVISAFFREKGLVSQQLDSFNQFVDYTLQDIICEDSTLILEQLAQHTTESDNISRKYEISFGKIYVTKPMVNESDGVTHALYPQEARLRNLTYSSGLFVDVKKRTYEAIDVPGRELKYELIAEESEDDSESGKVFIGRLPIMLRSKNCYLSEATESDLYKLKECPFDMGGYFIINGSEKVLIAQERSAGNIVQVFKKAAPSPISHVAEIRSALEKGSRFISTLQVKLYGREGSSARTIKATLPYIKQDIPIVIIFRALGIIPDGEILEHICYDVNDWQMLEMLKPCVEDGFVIQDRETALDFIGRRGTALGIKKEKRIQYAKDILQKEFLPHITQLEGFESRKAFFLGYMINRLLLCALDRKDQDDRDHFGKKRLDLAGPLLAQLFKTLFKKLTKDIFRYMQRTVEEAHDFNMKLAINAKTITSGLKYALATGNWGEQKKAMSSRAGVSQVLNRYTYSSTLSHLRRTNTPIGRDGKLAKPRQLHNTHWGLVCPAETPEGQACGLVKNLSLMSCISVGTDPMPIITFLSEWGMEPLEDYVPHQSPDATRVFVNGVWHGVHRNPARLMETLRTLRRKGDINPEVSMIRDIREKELKIFTDAGRVYRPLFIVEDDESLGHKELKVRKGHIAKLMATEYQDIEGGFEDVEEYTWSSLLNEGLVEYIDAEEEESILIAMQPEDLEPAEANEENDLDVDPAKRIRVSHHATTFTHCEIHPSMILGVAASIIPFPDHNQSPRNTYQSAMGKQAMGVFLTNYNVRMDTMANILYYPQKPLGTTRAMEYLKFRELPAGQNAIVAIACYSGYNQEDSMIMNQSSIDRGLFRSLFFRSYMDQEKKYGMSITETFEKPQRTNTLRMKHGTYDKLDDDGLIAPGVRVSGEDVIIGKTTPISPDEEELGQRTAYHSKRDASTPLRSTENGIVDQVLVTTNQDGLKFVKVRVRTTKIPQIGDKFASRHGQKGTIGITYRREDMPFTAEGIVPDLIINPHAIPSRMTVAHLIECLLSKVAALSGNEGDASPFTDITVEGISKLLREHGYQSRGFEVMYNGHTGKKLMAQIFFGPTYYQRLRHMVDDKIHARARGPMQVLTRQPVEGRSRDGGLRFGEMERDCMIAHGAASFLKERLMEASDAFRVHICGICGLMTVIAKLNHNQFECKGCDNKIDIYQIHIPYAAKLLFQELMAMNITPRLYTDRSRDF,negative +GGGCGAAUUCAACUGCCAUCUAGGCAGUAACCAGGAGUUAGUAGGACAAGUUUCGUCC,PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGKISKIGPENPYNTPVFAIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDESFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPXRXKNPEMVIYQYMDDLYVGSDLEIGQHRAKIEELRSHLLSWGFTTPDKKHQKEPPFLWMGYELHPDSWTVQPIELPEKDSWTVNE,negative +CTCCTCTGACTGTAACCACGCCCATATCGGTGAATGCACGAGCAACCCGATTGACACGGGGCATAGGTAGTCCAGAAGCC,DHNPPTIELIQRFCSDVDMWLKEDSSNVVAVHCKAGKGRTGTMICAYLVFSGIKKSADEALAWYDEKRTKDRKGVTIPSQRRYVQYFSKLVCSSVPYSKVSLNVCEIRFSESSCVQNLGMVECSISVLHDSATENAKPDRLKTLPIDFQKSFVLTIKPSIPVSGDVKFELTKKSPDKIICHFWLNTFFVRNYSPCESDGTVNKYIHTLSKSEIDDVHKDSEHKRFSEEFKISIVFEAENFSNDVQAEASEKERNENVLNFERSDYDSLSPNCYAEKKVLTAIVNDNTTKSQTIETLDHKDIVTKIQYDTSTNSKNTSTACKRKQPNSKTLLPSLNDSTKEEIKRNHIFNQPSIKKTDLIKWQNSEVHITRSINENKNINYNSYITCKQSSPKFNCGTEDGEEDWESGESTYL,negative +CACUCAGCGCCCUGCGAAACGUUGCCGCCUCCCAACGUCU,QDRPIKFSTEGATSQSYKQFIEALRERLRGGLIHDIPVLPDPTTLQERNRYITVELSNSDTESIEVGIDVTNAYVVAYRAGTQSYFLRDAPSSASDYLFTGTDQHSLPFYGTYGDLERWAHQSRQQIPLGLQALTHGISFFRSGGNDNEEKARTLIVIIQMVAEAARFRYISNRVRVSIQTGTAFQPDAAMISLENNWDNLSRGVQESVQDTFPNQVTLTNIRNEPVIVDSLSHPTVAVLALMLFVCNPPNANQSPLLIRSIVEKSKICSSRYEPTVRIGGRDGMCVDVYDNGYHNGNRIIMWKCKDRLEENQLWTLKSDKTIRSNGKCLTTYGYAPGSYVMIYDCTSAVAEATYWEIWDNGTIINPKSALVLSAESSSMGGTLTVQTNEYLMRQGWRTGNNTSPFVTSISGYSDLCMQAQGSNVWMADCDSNKKEQQWALYTDGSIRSVQNTNNCLTSKDHKQGSTILLMGCSNGWASQRWVFKNDGSIYSLYDDMVMDVKGSDPSLKQIILWPYTGKPNQIWLTLF,negative +GUAUUCUCGGUGGUUUAAUCAGAGUAGAGGAGGCUGACUCCUUUGGUUGGUCUACGUGGAGGUUCUUUUG,MSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEMLDRHHTHFCPLEGESWQDFLRNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAFLCQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERETPTTDSMPPLLRQAIELFDHQGAEPAFLFGLELIICGLEKQLKCESGS,negative +GGUAGAUACGAUGGAUCAGGGUACCCCCUGUGGCCCGUCAACACAGGGGAAGUGGCAUGACGCGCAGCCA,MVKSHIGSWILVLFVAMWSDVGLCKKRPKPGGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGTHGQWNKPSKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGSDYEDRYYRENMHRYPNQVYYRPVDQYSNQNNFVHDCVNITVKEHTVTTTTKGENFTETDIKMMERVVEQMCITQYQRESQAYYQRGASVILFSSPPVILLISFLIFLIVG,negative +UCACUCUAUACCUCAAACGAAGUUGCACAACCCC,MKRASAGGSRLLAWVLWLQAWQVAAPCPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDNPWVCDCRARPLWAWLQKFRGSSSEVPCSLPQRLAGRDLKRLAANDLQGCAVATGPYHPIWTGRATDEEPLGLPKCCQPDAADKASVLEPGRPASAGNALKGRVPPGDSPPGNGSGPRHINDSPFGTLPGSAEPPLTAVRPEGSEPPGFPTSGPRRRPGCSRKNRTRSHCRLGQAGSGGGGTGDSEGSGALPSLTCSLTPLGLALVLWTVLGPC,negative +CACCGCAUUGAGCCCAGAGACGCCACAGAC,MDKFWWHAAWGLCLVPLSLAQIDLNITCRFAGVFHVEKNGRYSISRTEAADLCKAFNSTLPTMAQMEKALSIGFETCRYGFIEGHVVIPRIHPNSICAANNTGVYILTSNTSQYDTYCFNASAPPEEDCTSVTDLPNAFDGPITITIVNRDGTRYVQKGEYRTNPEDIYPSNPTDDDVSSGSSSERSSTSGGYIFYTFSTVHPIPDEDSPWITDSTDRIPATTLMSTSATATETATKRQETWDWFSWLFLPSESKNHLHTTTQMAGTSSNTISAGWEPNEENEDERDRHLSFSGSGIDDDEDFISSTISTTPRAFDHTKQNQDWTQWNPSHSNPEVLLQTTTRMTDVDRNGTTAYEGNWNPEAHPPLIHHEHHEEEETPHSTSTIQATPSSTTEETATQKEQWFGNRWHEGYRQTPKEDSHSTTGTAAASAHTSHPMQGRTTPSPEDSSWTDFFNPISHPMGRGHQAGRRMDMDSSHSITLQPTANPNTGLVEDLDRTGPLSMTTQQSNSQSFSTSHEGLEEDKDHPTTSTLTSSNRNDVTGGRRDPNHSEGSTTLLEGYTSHYPHTKESRTFIPVTSAKTGSFGVTAVTVGDSNSNVNRSLSGDQDTFHPSGGSHTTHGSESDGHSHGSQEGGANTTSGPIRTPQIPEWLIILASLLALALILAVCIAVNSRRRCGQKKKLVINSGNGAVEDRKPSGLNGEASKSQEMVHLVNKESSETPDQFMTADETRNLQNVDMKIGV,negative +AAAACCUACAACACACCCCUCAACUUUCCC,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,negative +CGGACGAAATTCGTCCCTGTGTG,MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYTFLLPEMDNCRSSSSPYVSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQDNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVLVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF,negative +AUCGUACAGAGGCAAGCAGAACGCGCGGU,MEGMLKGEGPGPLPPLLQQYVELRDQYPDYLLLFQVGDFYECFGEDAERLARALGLVLTHKTSKDFTTPMAGIPLRAFEAYAERLLKMGFRLAVADQVEPAEEAEGLVRREVTQLLTPGTLLQESLLPREANYLAAIATGDGWGLAFLDVSTGEFKGTVLKSKSALYDELFRHRPAEVLLAPELLENGAFLDEFRKRFPVMLSEAPFEPEGEGPLALRRARGALLAYAQRTQGGALSLQPFRFYDPGAFMRLPEATLRALEVFEPLRGQDTLFSVLDETRTAPGRRLLQSWLRHPLLDRGPLEARLDRVEGFVREGALREGVRRLLYRLADLERLATRLELGRASPKDLGALRRSLQILPELRALLGEEVGLPDLSPLKEELEAALVEDPPLKVSEGGLIREGYDPDLDALRAAHREGVAYFLELEERERERTGIPTLKVGYNAVFGYYLEVTRPYYERVPKEYRPVQTLKDRQRYTLPEMKEKEREVYRLEALIRRREEEVFLEVRERAKRQAEALREAARILAELDVYAALAEVAVRYGYVRPRFGDRLQIRAGRHPVVERRTEFVPNDLEMAHELVLITGPNMAGKSTFLRQTALIALLAQVGSFVPAEEAHLPLFDGIYTRIGASDDLAGGKSTFMVEMEEVALILKEATENSLVLLDEVGRGTSSLDGVAIATAVAEALHERRAYTLFATHYFELTALGLPRLKNLHVAAREEAGGLVFYHQVLPGPASKSYGVEVAAMAGLPKEVVARARALLQAMAARREGALDAVLERLLALDPDRLTPLEALRLLQELKALALGAPLDTMKG,negative +ACACTCTTTTGCTCGTGTTTTTGCCTGTTACATAAAATGAATCAGTGGATGTTTCCTTCT,MLNQLDNLTERVRGSNKLVDRWLHVRKHLLVAYYNLVGIKPGKESYMRLNEKALDDFCQSLVDYLSAGHFSIYERILHKLEGNGQLARAAKIWPQLEANTQQIMDYYDSSLETAIDHDNYLEFQQVLSDIGEALEARFVLEDKLILLVLDAARVKHPA,negative +AUCAGUCCCCACUGCCCCCGCUUGCAGACA,MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA,negative +AGGACUGAAAUAUUCACGUUGACGUUGUCUUGGAGUGCUGAUCGGAAAACCAAUAUGAUUAAGGGUCCUG,MDHLNEATQGKEHSEMSNNVSDPKGPPAKIARLEQNGSPLGRGRLGSTGAKMQGVPLKHSGHLMKTNLRKGTMLPVFCVVEHYENAIEYDCKEEHAEFVLVRKDMLFNQLIEMALLSLGYSHSSAAQAKGLIQVGKWNPVPLSYVTDAPDATVADMLQDVYHVVTLKIQLHSCPKLEDLPPEQWSHTTVRNALKDLLKDMNQSSLAKECPLSQSMISSIVNSTYYANVSAAKCQEFGRWYKHFKKTKDMMVEMDSLSELSQQGANHVNFGQQPVPGNTAEQPPSPAQLSHGSQPSVRTPLPNLHPGLVSTPISPQLVNQQLVMAQLLNQQYAVNRLLAQQSLNQQYLNHPPPVSRSMNKPLEQQVSTNTEVSSEIYQWVRDELKRAGISQAVFARVAFNRTQGLLSEILRKEEDPKTASQSLLVNLRAMQNFLQLPEAERDRIYQDERERSLNAASAMGPAPLISTPPSRPPQVKTATIATERNGKPENNTMNINASIYDEIQQEMKRAKVSQALFAKVAATKSQGWLCELLRWKEDPSPENRTLWENLSMIRRFLSLPQPERDAIYEQESNAVHHHGDRPPHIIHVPAEQIQQQQQQQQQQQQQQQAPPPPQPQQQPQTGPRLPPRQPTVASPAESDEENRQKTRPRTKISVEALGILQSFIQDVGLYPDEEAIQTLSAQLDLPKYTIIKFFQNQRYYLKHHGKLKDNSGLEVDVAEYKEEELLKDLEESVQDKNTNTLFSVKLEEELSVEGNTDINTDLKD,negative +AAGCCGGAUGCACGAAUAUUGAGGUAAGCG,MSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEMLDRHHTHFCPLEGESWQDFLRNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAFLCQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERETPTTDSMPPLLRQAIELFDHQGAEPAFLFGLELIICGLEKQLKCESGS,negative +CACCUACCUAAUUAUUAAACUUUGGGCAGUAUCCCGCUUUGCUUCUUAUC,MAITKINDCFELLSMVTYADKLKSLIKKEFSISFEEFAVLTYISENKEKEYYLKDIINHLNYKQPQVVKAVKILSQEDYFDKKRNEHDERTVLILVNAQQRKKIESLLSRVNKRITEANNEIEL,negative +UAAAUCGUUGCUACAUUCCCAAUUGAACGGCCCGGGUUCUUAACACGUGC,MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICEVEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASSIVYKKEGEQVEFSFPLAFTVEKLTGSGELWWQAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLPQALPQYAGSGNLTLALEAKTGKLHQEVNLVVMRATQLQKNLTCEVWGPTSPKLMLSLKLENKEAKVSKREKAVWVLNPEAGMWQCLLSDSGQVLLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQAERMSQIKRLLSEKKTCQCPHRFQKTCSPI,negative +CCCUGAUGGUAGACGCCGGGGUGCCGGAA,MSGGDGRGHNTGAHSTSGNINGGPTGLGVGGGASDGSGWSSENNPWGGGSGSGIHWGGGSGHGNGGGNGNSGGGSGTGGNLSAVAAPVAFGFPALSTPGAGGLAVSISAGALSAAIADIMAALKGPFKFGLWGVALYGVLPSQIAKDDPNMMSKIVTSLPADDITESPVSSLPLDKATVNVNVRVVDDVKDERQNISVVSGVPMSVPVVDAKPTERPGVFTASIPGAPVLNISVNNSTPAVQTLSPGVTNNTDKDVRPAGFTQGGNTRDAVIRFPKDSGHNAVYVSVSDVLSPDQVKQRQDEENRRQQEWDATHPVEAAERNYERARAELNQANEDVARNQERQAKAVQVYNSRKSELDAANKTLADAIAEIKQFNRFAHDPMAGGHRMWQMAGLKAQRAQTDVNNKQAAFDAAAKEKSDADAALSSAMESRKKKEDKKRSAENNLNDEKNKPRKGFKDYGHDYHPAPKTENIKGLGDLKPGIPKTPKQNGGGKRKRWTGDKGRKIYEWDSQHGELEGYRASDGQHLGSFDPKTGNQLKGPDPKRNIKKYL,negative +AGCGCGCACCTACTGTGATGAAGAAGTCACAGCAAGGCCC,MTPDIQAPFLSLLLLFPVLTVANVPTLTTSDSINPRRTTPVSTTQSSPTSSPTKETSWSTTTTLLTASSPAPSPAASPGHDGASTPTSSPAPSPAASPGHDGASTPTSSPAPSPAASPGHDGASTPTSSPAPSPAASPGHDGASTPTSSPAPSPAASPGHNGTSSPTGSPAPSPAASPGHDGASTPTSSPAPSPAASPGHNGTSSPTGSPAPSPAASPGHDGASTPTSSPAPSPAASPGHNGTSSPTGSPAPSPTASPGHDSAPSLTSSPAPSPTASPGQHGASSPTSSDTSSMTTRSMSSSMVTSAHKGTSSRATMTPVSKGTPSSVPSSETAPTAASHITRTAASSPSIALSTSSNPKTSQQLSVRVSLYFLSFRITNLQFNSSLENPQTSYYQELQRSIWGLILQIYKQRDFLGLSEIKFRPGSVVVELTLAFREGTTAEWVKAQFSQLEAHAASYNLTISGVSVYSAPFPSSAQAGSGVPGWGIALLVLVCVLVALAIIYLIALVVCQCGRKKCEQLDVFPTLDAYHPMSEYSTYHTHGRYVPPGSTKRSPYEEVSAGNGGSNLSYTNLAATSANL,negative +CGTGTCGTATTGAGTGATATGATGCACATA,MQQGQMAYDRAITVFSPDGRLFQVEYAREAVKKGSTALGMKFANGVLLISDKKVRSRLIEQNSIEKIQLIDDYVAAVTSGLVADARVLVDFARISAQQEKVTYGSLVNIENLVKRVADQMQQYTQYGGVRPYGVSLIFAGIDQIGPRLFDCDPAGTINEYKATAIGSGKDAVVSFLEREYKENLPEKEAVTLGIKALKSSLEEGEELKAPEIASITVGNKYRIYDQEEVKKFL,negative +TGGGGGTCGGGATACGGTCAGTGGTGGTGAGTGGTAACGG,MDKLVVNYYEYKHPIINKDLAIGAHGGKKFPTLGAWYDVINEYEFQTRCPIILKNSHRNKHFTFACHLKNCPFKVLLSYAGNAASSETSSPSANNNTNPPGTPDHIHHHSNNMNNEDNDNNNGSNNKVSNDSKLDFVTDDLEYHLANTHPDDTNDKVESRSNEVNGNNDDDADANNIFKQQGVTIKNDTEDDSINKASIDRGLDDESGPTHGNDSGNHRHNEEDDVHTQMTKNYSDVVNDEDINVAIANAVANVDSQSNNKHDGKDDDATNNNDGQDNNTNNDHNNNSNINNNNVGSHGISSHSPSSIRDTSMNLDVFNSATDDIPGPFVVTKIEPYHSHPLEDNLSLGKFILTKIPKILQNDLKFDQILESSYNNSNHTVSKFKVSHYVEESGLLDILMQRYGLTAEDFEKRLLSQIARRITTYKARFVLKKKKMGEYNDLQPSSSSNNNNNNDGELSGTNLRSNSIDYAKHQEISSAGTSSNTTKNVNNNKNDSNDDNNGNNNNDASNLMESVLDKTSSHRYQPKKMPSVNKWSKPDQITHSDVSMVGLDESNDGGNENVHPTLAEVDAQEARETAQLAIDKINSYKRSIDDKNGDGHNNSSRNVVDENLINDMDSEDAHKSKRQHLSDITLEERNEDDKLPHEVAEQLRLLSSHLKEVENLHQNNDDDVDDVMVDVDVESQYNKNTTHHNNHHSQPHHDEEDVAGLIGKADDEEDLSDENIQPELRGQ,negative +UAGGGAGAGAACUGUGUCAGAAUGUAGUGAACCAGACACGGAGUGGAGUA,MKKRKVLIPLMALSTILVSSTGNLEVIQAEVKQENRLLNESESSSQGLLGYYFSDLNFQAPMVVTSSTTGDLSIPSSELENIPSENQYFQSAIWSGFIKVKKSDEYTFATSADNHVTMWVDDQEVINKASNSNKIRLEKGRLYQIKIQYQRENPTEKGLDFKLYWTDSQNKKEVISSDNLQLPELKQKSSNSRKKRSTSAGPTVPDRDNDGIPDSLEVEGYTVDVKNKRTFLSPWISNIHEKKGLTKYKSSPEKWSTASDPYSDFEKVTGRIDKNVSPEARHPLVAAYPIVHVDMENIILSKNEDQSTQNTDSQTRTISKNTSTSRTHTSEVHGNAEVHASFFDIGGSVSAGFSNSNSSTVAIDHSLSLAGERTWAETMGLNTADTARLNANIRYVNTGTAPIYNVLPTTSLVLGKNQTLATIKAKENQLSQILAPNNYYPSKNLAPIALNAQDDFSSTPITMNYNQFLELEKTKQLRLDTDQVYGNIATYNFENGRVRVDTGSNWSEVLPQIQETTARIIFNGKDLNLVERRIAAVNPSDPLETTKPDMTLKEALKIAFGFNEPNGNLQYQGKDITEFDFNFDQQTSQNIKNQLAELNATNIYTVLDKIKLNAKMNILIRDKRFHYDRNNIAVGADESVVKEAHREVINSSTEGLLLNIDKDIRKILSGYIVEIEDTEGLKEVINDRYDMLNISSLRQDGKTFIDFKKYNDKLPLYISNPNYKVNVYAVTKENTIINPSENGDTSTNGIKKILIFSKKGYEIG,negative +UUAACUCCCAACGCAUCAAUCCCGAUCCGUGACUCCGCC,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,negative +UCAAUCGGCGCUUUACUCUUGCGCUCACCGUGCCC,MEDDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKEEIAEVANEIESLGSTEERKNMQRNKQVAMGRKKFNMDPKKGIQFLIENGLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERDEFSIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNTGVFQSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIKNEPFKIPVWFFLQNLYESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEDWIKCIKAAISRDPFYEMLAARKKKVSSTKRH,negative +AGCGCGGGAUGUUAUGGCACGAUGUGUAGAGAAUAGCGCUGAUCGGGCAA,MACAAARSPADQDRFICIYPAYLNNKKTIAEGRRIPISKAVENPTATEIQDVCSAVGLNVFLEKNKMYSREWNRDVQYRGRVRVQLKQEDGSLCLVQFPSRKSVMLYAAEMIPKLKTRTQKTGGADQSLQQGEGSKKGKGKKKK,negative +AUCCCUGAACCGGCCCAGCAGACUACUGACGGCACGAU,AKVLVVLLLFAGVDAETHVTGGSAAHAASTFAGLFSPGAKQDIQLINTNGSWHINRTA,negative +GGTTGGTGTGGTTGG,MAGRSGDSDEELLKAVRLIKFLYQSNPPPNPEGTRQARRNRRRRWRERQRQIHSISERILSTYLGRSAEPVPLQLPPLERLTLDCNEDCGTSGTQGVGSPQILVESPTILESGAKE,negative +AACUAGCAGGCAGAGAAGAGUGGGUGCGACCACAGGAUGUUAUGGCCUG,MLSWGYFLFLLPTLPGAQSQVQLVESGGDVRKPGDSLRLSCKGSGFTFSNYWLGWVRQAPGKALNGSLPLTPLAAAPTYIPGVSGRFTISRDNARALLHLDMSDLRPEDTGRYHCER,negative +GGUUGGGUUGUCGUAGAUAUAGCUUAGCCA,MDHLNEATQGKEHSEMSNNVSDPKGPPAKIARLEQNGSPLGRGRLGSTGAKMQGVPLKHSGHLMKTNLRKGTMLPVFCVVEHYENAIEYDCKEEHAEFVLVRKDMLFNQLIEMALLSLGYSHSSAAQAKGLIQVGKWNPVPLSYVTDAPDATVADMLQDVYHVVTLKIQLHSCPKLEDLPPEQWSHTTVRNALKDLLKDMNQSSLAKECPLSQSMISSIVNSTYYANVSAAKCQEFGRWYKHFKKTKDMMVEMDSLSELSQQGANHVNFGQQPVPGNTAEQPPSPAQLSHGSQPSVRTPLPNLHPGLVSTPISPQLVNQQLVMAQLLNQQYAVNRLLAQQSLNQQYLNHPPPVSRSMNKPLEQQVSTNTEVSSEIYQWVRDELKRAGISQAVFARVAFNRTQGLLSEILRKEEDPKTASQSLLVNLRAMQNFLQLPEAERDRIYQDERERSLNAASAMGPAPLISTPPSRPPQVKTATIATERNGKPENNTMNINASIYDEIQQEMKRAKVSQALFAKVAATKSQGWLCELLRWKEDPSPENRTLWENLSMIRRFLSLPQPERDAIYEQESNAVHHHGDRPPHIIHVPAEQIQQQQQQQQQQQQQQQAPPPPQPQQQPQTGPRLPPRQPTVASPAESDEENRQKTRPRTKISVEALGILQSFIQDVGLYPDEEAIQTLSAQLDLPKYTIIKFFQNQRYYLKHHGKLKDNSGLEVDVAEYKEEELLKDLEESVQDKNTNTLFSVKLEEELSVEGNTDINTDLKD,negative +ATACCAGTCTATTCAATTTGGCGGCGGGGGGGGAGCGGTTTCATCGTGAGATAGTATGTGCAATCA,MLNQLDNLTERVRGSNKLVDRWLHVRKHLLVAYYNLVGIKPGKESYMRLNEKALDDFCQSLVDYLSAGHFSIYERILHKLEGNGQLARAAKIWPQLEANTQQIMDYYDSSLETAIDHDNYLEFQQVLSDIGEALEARFVLEDKLILLVLDAARVKHPA,negative +TACGACCAATACGCCCAATACTGCTCCGACTGCTGCATTATCCAC,MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPGPHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR,negative +GGGAGGACGCGUCGCCGUAAUGGAUGUUUUGCUCCCUG,MHGDTPTLHEYMLDLQPETTDLYCYEQLNDSSEEEDEIDGPAGQAEPDRAHYNIVTFCCKCDSTLRLCVQSTHVDIRTLEDLLMGTLGIVCPICSQKP,negative +GGGAGAGGAGGGAGAUAGAUAUCAAGAUAAAAACGCCGGCGUAGCGCUGCAGCGCAAAAAAACACGACUGCUCGCACGAGGUGACUCAGGCAGAGAAGGCGAGUUUCGUGGAUGCCACAGGAC,MPSNQEARLFLAVLVLAQVLPILVDSAAEKGFKQAFWQPLCQVSEELDDQPKGALFTLQAAASKIQKMRDAALRASIYAEINHGTNRAKAAVIVANHYAMKADSGLEALKQTLSSQEVTATATASYLKGRIDEYLNLLLQTKESGTSGCMMDTSGTNTVTKAGGTIGGVPCKLQLSPIQPKRPAATYLGKAGYVGLTRQADAANNFHDNDAECRLASGHNTNGLGKSGQLSAAVTMAAGYVTVANSQTAVTVQALDALQEASGAAHQPWIDAWKAKKALTGAETAEFRNETAGIAGKTGVTKLVEEALLKKKDSEASEIQTELKKYFSGHENEQWTAIEKLISEQPVAQNLVGDNQPTKLGELEGNAKLTTILAYYRMETAGKFEVLTQKHKPAESQQQAAETEGSCNKKDQNECKSPCKWHNDAENKKCTLDKEEAKKVADETAKDGKTGNTNTTGSSNSFVISKTPLWLAVLLF,negative +GCAATGGTACGGTACTTCCTGTGGCGAGGTAGGTGGGGTGTGTGTGTATCCAAAAGTGCACGCTACTTTGCTAA,MSAPASTTQATGSTTSTTTKTAGATPATASGLFTIPDGDFFSTARAVVASDAVATNEDLSEIEAVWKDMKVPTDTMAQAAWDLVRHCADVGSSAQTEMIDTGPYSNGISRARLAAAIKEVCTLRQFCMKYAPVVWNWMLTNNSPPANWQAQGFKPEHKFAAFDFFNGVTNPAAIMPKEGLIRPPSEAEMNAAQTAAFVKITKARAQSNDFASLDAAVTRGRITGTTTAEAVVTLPPP,negative +CTTCTGCCCGCCTCCTTCCAGAGTAGCCAAGCGGAGAGTATTTTTGACTGCTTCCCCCGGAGACGAGATAGGCGGACACT,MDKLVVNYYEYKHPIINKDLAIGAHGGKKFPTLGAWYDVINEYEFQTRCPIILKNSHRNKHFTFACHLKNCPFKVLLSYAGNAASSETSSPSANNNTNPPGTPDHIHHHSNNMNNEDNDNNNGSNNKVSNDSKLDFVTDDLEYHLANTHPDDTNDKVESRSNEVNGNNDDDADANNIFKQQGVTIKNDTEDDSINKASIDRGLDDESGPTHGNDSGNHRHNEEDDVHTQMTKNYSDVVNDEDINVAIANAVANVDSQSNNKHDGKDDDATNNNDGQDNNTNNDHNNNSNINNNNVGSHGISSHSPSSIRDTSMNLDVFNSATDDIPGPFVVTKIEPYHSHPLEDNLSLGKFILTKIPKILQNDLKFDQILESSYNNSNHTVSKFKVSHYVEESGLLDILMQRYGLTAEDFEKRLLSQIARRITTYKARFVLKKKKMGEYNDLQPSSSSNNNNNNDGELSGTNLRSNSIDYAKHQEISSAGTSSNTTKNVNNNKNDSNDDNNGNNNNDASNLMESVLDKTSSHRYQPKKMPSVNKWSKPDQITHSDVSMVGLDESNDGGNENVHPTLAEVDAQEARETAQLAIDKINSYKRSIDDKNGDGHNNSSRNVVDENLINDMDSEDAHKSKRQHLSDITLEERNEDDKLPHEVAEQLRLLSSHLKEVENLHQNNDDDVDDVMVDVDVESQYNKNTTHHNNHHSQPHHDEEDVAGLIGKADDEEDLSDENIQPELRGQ,negative +UCUACCGCCUGCCCUAGCCGAA,MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYTFLLPEMDNCRSSSSPYVSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQDNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVLVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF,negative +GGGAGCTCAGAATAAACGCTCAAGGATGGGTGGGTGGGGAGGTTGTAGACTGTATTTCGACATGAGGCCCGGATC,QELLCAASLISDRWVLTAAHCLLYPPWDKNFTVNDILVRIGKYARSRYERNMEKISTLEKIIIHPGYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDKQIVTSLLQAGHKGRVTGWGNLKEMWTVNMNEVQPSVLQMVNLPLVERPICKASTGIRVTDNMFCAGYKPEEGKRGDACEGDSGGPFVMKNPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIRKMVDRFG,negative +UAUCCUCGCCCGUGCACGCCCUCCACUAAGCCCA,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +ACCGAAAAAGACCUGACUUCUAUACUAAGUCUACGUUCC,PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGKISKIGPENPYNTPVFAIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDESFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPXRXKNPEMVIYQYMDDLYVGSDLEIGQHRAKIEELRSHLLSWGFTTPDKKHQKEPPFLWMGYELHPDSWTVQPIELPEKDSWTVNE,negative +UAUCCUCCAGAGCAUCGCCGUCCAUAACCACUUACCUCCU,MNRNCASPEEGGTTEQLVKEASDIVERDGFENKKKPPTLKLEHVEVVGEKSPTPATVYDLFKKYKKPDIVTNSNGDDMNVGFDQLSSDEKNGFLRKLQMLTVSSRKSVKVVGESTPSSAGRLLKKFAPSRKPTEKISVDEPPSRFNFFGRSTKKLSDSDRPSSLPKKKSARRLLFGKEEQKPEPEVVKNRVLPAMTSQQSAKGAPIPINKPYRYQGPRGSLETPTDSPAKISSNSSSSSPIPPVPTRNHFTSMNEESPSKKRTFSRQGLSNRDNLSNGSWHGELPPRDYTSPTFSRKIFVGGVPWDITEAALKDSFGEFGSCAVEWPGQEARYRSGQSNIAPLTNLRNQSKYAGQAATGYVYMIFEDERAVASLLHECSQEIGGAGEWYFKIRAQRSKSTEIRQVQIIPWVTSDSMFCEDESLLETGIEPKRTVFVGALHGMMTAQVLHWIMEDCFGSVECVQLDTDKFKYPIGSGRVTFREHGAYFKAIEMGYLHVHTSKFRKRVQIDPFLESTSCMVCTTESAQCFCRNRNCFKYYCHTCWAIDHGKDNADDVHVPVIVPSSASKAYAGPHRRPHLTSNSLSKSHGCSTNNQLSHVLSPGFPMIVGGPSQTLSALYGYIQNNQQMMLTPAVYETPMTPPSNESNAKRRSFTEFQNPAIFFNPSSMMTPQKSATCSETPVPAFFTNSAAFLTPNSNYYGSPNHSSSNISQSPQQYYGANLYYGYMPPQVAYDGSTNGSKLSPIHVPHIPNYQ,negative +GGGAGAAUUCAACUGCCAUCUAGGCAGUAGGAAUACCCCCAUCCAAAGCUCGCUAGGCUGAACACAGUACUACAAGCUUCUGGACUCGGU,MRKIVVAAIAVSLTTVSITASASADPSKDSKAQVSAAEAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKVKPSAASIDAAKKAGVNNGNPLDAVQQ,negative +GGGAGCTCAGAATAAACGCTCAAGGGTTGGGTGGGGAGGTTGTAGAATGCAGGGGTTCGACATGAGGCCCGGATC,MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICEVEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASSIVYKKEGEQVEFSFPLAFTVEKLTGSGELWWQAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLPQALPQYAGSGNLTLALEAKTGKLHQEVNLVVMRATQLQKNLTCEVWGPTSPKLMLSLKLENKEAKVSKREKAVWVLNPEAGMWQCLLSDSGQVLLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQAERMSQIKRLLSEKKTCQCPHRFQKTCSPI,negative +TTTCTAGGAAATTCAAACAGGTTTGTATTTTTCTAGTTGA,MSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEMLDRHHTHFCPLEGESWQDFLRNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAFLCQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERETPTTDSMPPLLRQAIELFDHQGAEPAFLFGLELIICGLEKQLKCESGS,negative +ACTACACGAGGACCTACGACTACTACATTATGCCAACCGGTCTTGCTTCGACACAGATACCTC,MDKLVVNYYEYKHPIINKDLAIGAHGGKKFPTLGAWYDVINEYEFQTRCPIILKNSHRNKHFTFACHLKNCPFKVLLSYAGNAASSETSSPSANNNTNPPGTPDHIHHHSNNMNNEDNDNNNGSNNKVSNDSKLDFVTDDLEYHLANTHPDDTNDKVESRSNEVNGNNDDDADANNIFKQQGVTIKNDTEDDSINKASIDRGLDDESGPTHGNDSGNHRHNEEDDVHTQMTKNYSDVVNDEDINVAIANAVANVDSQSNNKHDGKDDDATNNNDGQDNNTNNDHNNNSNINNNNVGSHGISSHSPSSIRDTSMNLDVFNSATDDIPGPFVVTKIEPYHSHPLEDNLSLGKFILTKIPKILQNDLKFDQILESSYNNSNHTVSKFKVSHYVEESGLLDILMQRYGLTAEDFEKRLLSQIARRITTYKARFVLKKKKMGEYNDLQPSSSSNNNNNNDGELSGTNLRSNSIDYAKHQEISSAGTSSNTTKNVNNNKNDSNDDNNGNNNNDASNLMESVLDKTSSHRYQPKKMPSVNKWSKPDQITHSDVSMVGLDESNDGGNENVHPTLAEVDAQEARETAQLAIDKINSYKRSIDDKNGDGHNNSSRNVVDENLINDMDSEDAHKSKRQHLSDITLEERNEDDKLPHEVAEQLRLLSSHLKEVENLHQNNDDDVDDVMVDVDVESQYNKNTTHHNNHHSQPHHDEEDVAGLIGKADDEEDLSDENIQPELRGQ,negative +UUAACCAUCAGCUCAUGGCCCCUGCCCUCUCAAGGACCAC,MSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA,negative +CTCCTCTGACTGTAACCACGCCCATATCGGTGAATGCACGAGCAACCCGATTGACACGGGGCATAGGTAGTCCAGAAGCC,MVKSHIGSWILVLFVAMWSDVGLCKKRPKPGGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGSHSQWNKPSKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGNDYEDRYYRENMYRYPNQVYYRPVDRYSNQNNFVHDCVNITVKQHTVTTTTKGENFTETDIKIMERVVEQMCITQYQRESQAYYQRGASVILFSSPPVILLISFLIFLIVG,negative +TGACTGCCGCACCGACCATTCACGGTATTGGCACGGCC,MKKTLIALAIAASAASGMAHAWMTGDFNGSVDIGGSITADDYRQKWEWKVGTGLNGFGNVLNDLTNGGTKLTITVTGNKPILLGRTKEAFATPVTGGVDGIPHIAFTDYEGASVVLRNPDGETNKKGLAYFVLPMKNAEGTKVGSVKVNASYAGVLGRGGVTSADGELLSLFADGLSSIFYGGLPRGSELSAGSAAAARTKLFGSLSRNDILGQIQRVNANITSLVDVAGSYRENMEYTDGTVVSAAYALGIANGQTIEATFNQAVTTSTQWSAPLNVAITYY,negative +UCACCCUGAACCGGCCCAGCAGACUGCUGACGGCACGAU,MDKLVVNYYEYKHPIINKDLAIGAHGGKKFPTLGAWYDVINEYEFQTRCPIILKNSHRNKHFTFACHLKNCPFKVLLSYAGNAASSETSSPSANNNTNPPGTPDHIHHHSNNMNNEDNDNNNGSNNKVSNDSKLDFVTDDLEYHLANTHPDDTNDKVESRSNEVNGNNDDDADANNIFKQQGVTIKNDTEDDSINKASIDRGLDDESGPTHGNDSGNHRHNEEDDVHTQMTKNYSDVVNDEDINVAIANAVANVDSQSNNKHDGKDDDATNNNDGQDNNTNNDHNNNSNINNNNVGSHGISSHSPSSIRDTSMNLDVFNSATDDIPGPFVVTKIEPYHSHPLEDNLSLGKFILTKIPKILQNDLKFDQILESSYNNSNHTVSKFKVSHYVEESGLLDILMQRYGLTAEDFEKRLLSQIARRITTYKARFVLKKKKMGEYNDLQPSSSSNNNNNNDGELSGTNLRSNSIDYAKHQEISSAGTSSNTTKNVNNNKNDSNDDNNGNNNNDASNLMESVLDKTSSHRYQPKKMPSVNKWSKPDQITHSDVSMVGLDESNDGGNENVHPTLAEVDAQEARETAQLAIDKINSYKRSIDDKNGDGHNNSSRNVVDENLINDMDSEDAHKSKRQHLSDITLEERNEDDKLPHEVAEQLRLLSSHLKEVENLHQNNDDDVDDVMVDVDVESQYNKNTTHHNNHHSQPHHDEEDVAGLIGKADDEEDLSDENIQPELRGQ,negative +GGTTGGTGTGGTTGG,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,negative +CAUGAGGUCUAUCACUGCAUCGACAGCUAGGCGGACAAUG,QELLCAASLISDRWVLTAAHCLLYPPWDKNFTVNDILVRIGKYARSRYERNMEKISTLEKIIIHPGYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDKQIVTSLLQAGHKGRVTGWGNLKEMWTVNMNEVQPSVLQMVNLPLVERPICKASTGIRVTDNMFCAGYKPEEGKRGDACEGDSGGPFVMKNPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIRKMVDRFG,negative +GGTGATCATGGCAGTGTACGCGGGCGGACA,MKEFEVKVASTAFVLVLFSLTINQILASETSTKFRSPVPAPTVPDWNHLPNEGNEENVVSAPKQDGASGGQKPYWTKREKMMKRLHAEPAGNTVRFRCAVDGNPKPQVLWYKNDLIVQKNDRVGGYKYRNQVLILESVVLSDKGNYMCVARNEYGSINHTYQLDVQERSASKPILAEGLPQNKSAYIGDDVTFKCKVYSDAHPHIQWLKSINNHNNAAPNYTVLKAAGVNTTDLDMEVLILKNVSFEEAGEYTCLAGNSIGISHQSAWLSVLPVPPPTTDTITKGIPNETNIIIYVMCGVLVILFGLAVVLVLYYHCYNGKDPPMLVRIENPDNIPPMTKIEHPTMLFGNTQAWQRMCMPMQEPFEFNIQLDLQWELQREDITLVERLDEGFFGQVFKADLVTCNNTRKEKMVCAVKMLKGNRNEKDVLDLLTEMDQMKRVGKHKNIINLLGVCTQNGPLWLVIEYAAQGNLRDYLRRNRPQNTLCNLVLPSEGRNPDDELPVPHGDTLTQKDIVSFAFQVARGLEFLAQKKCIHRDLAARNVLVTEELVMKIADFGLARDIRSCDYYRKHTRGHLPYKWMALEAMSDNIFTHATDVWSFGVLLWEIFSLAGSPYPGIKTHELVKFLRSGERLDKPQYASQEMYRLMRDCWEEDPSKRPNFRTLVEDLDRMLAESSTEVYIDFAAGCEAEYSESSEDESESQNSDEEDDDSVFERMRQIDSLSNGNIPFNEEDSSNSDPYVAPLLQNEENVLQNEHARLRSEA,negative +GCATGAATTCCCGAAGACGCAAACTGAAGAGGCACCGAAGGGGGGG,MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH,negative +CAGGCGTTAGGGAAGGGCGTCGAAAGCAGGGTGGG,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +ACCUAGCGCGCUUGACGUGGCCCCUUCGCAGGUCCUGGAU,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +AGUAAUACGACUCACUAUAGGGAGAAUUCCGACCAGAAGGGUUAGCGGUCGUCUUAAGUAGUUUUUGGUCCUUUCCUCUCUCCUUCCUCUUCU,MAIPKELLVLLLGIAILSKVAECAAFGSRRGLVETVFDVTRFGARPNTPADSTRGLMMAWRSACQSPGPAKVVIPPGTYTTGETIFQGPCTSPRPITIEIQGTLLSNTDMSLYTRAAWISIEHVDGIVITGGGTLNGQGKSSWQFADKSGSTPPLPSSLVFQTVRSSSIKNLNFVDAKGVHLKITDSSDISVSNIKITAPGDSPNTDGLHISDTINVNVTDSTIGTGDDCISIGDGNSNVYISNINCGPGHGISIGSLGKRLDETDVKGVTVRNCTFRGTTNGARIKTYMGSPSLQVSGVVYEDIILDNVKNPIVIDQHYHSKNRNEPSRVKLVDIHFRNIRGTTTSKIPVLLNCSEALPCEGVELVDIDLAPVGSIGPLLPATCQNAKTILNGKNNPPAC,negative +UUAUUAUUGUUUAUUUUGUGUUGUGUGUUUGUGUU,MLSWGYFLFLLPTLPGAQSQVQLVESGGDVRKPGDSLRLSCKGSGFTFSNYWLGWVRQAPGKALNGSLPLTPLAAAPTYIPGVSGRFTISRDNARALLHLDMSDLRPEDTGRYHCER,negative +ACAGATACGGAACTACAGAGGTCAATTACGGTGGCCACGC,MASNFTQFVLVDNGGTGDVTVAPSNFANGVAEWISSNSRSQAYKVTCSVRQSSAQNRKYTIKVEVPKVATQTVGGVELPVAAWRSYLNMELTIPIFATNSDCELIVKAMQGLLKDGNPIPSAIAANSGIY,negative +GUAGUCAAAAGUCAUACAGCUCUACCAACAGCUCGA,MKPGGNTIVIWMYAVATWLCFGSTSGWSFTLEDNNIFPKQYPIINFTTAGATVQSYTNFIRAVRGRLTTGADVRHEIPVLPNRVGLPINQRFILVELSNHAELSVTLALDVTNAYVVGYRAGNSAYFFHPDNQEDAEAITHLFTDVQNRYTFAFGGNYDRLEQLAGNLRENIELGNGPLEEAISALYYYSTGGTQLPTLARSFIICIQMISEAARFQYIEGEMRTRIRYNRRSAPDPSVITLENSWGRLSTAIQESNQGAFASPIQLQRRNGSKFSVYDVSILIPIIALMVYRCAPPPSSQFSLLIRPVVPNFNADVCMDPEPIVRIVGRNGLCVDVRDGRFHNGNAIQLWPCKSNTDANQLWTLKRDNTIRSNGKCLTTYGYSPGVYVMIYDCNTAATDATRWQIWDNGTIINPRSSLVLAATSGNSGTTLTVQTNIYAVSQGWLPTNNTQPFVTTIVGLYGLCLQANSGQVWIEDCSSEKAEQQWALYADGSIRPQQNRDNCLTSDSNIRETVVKILSCGPASSGQRWMFKNDGTILNLYSGLVLDVRASDPSLKQIILYPLHGDPNQIWLPLF,negative +GCTTTACCGCACTTCCGATCTTTAATTTCGAGTGTATCAT,MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP,negative +CGAUACAGCACUGAUUGCGGUCGAGGUAGCUUGAUGGGCC,MDSTNYISKLFEYAQRQGQISDIKFEEVGTDGPDHLKTFTLRVVIKGHAYPNGVGKTKKEAKRNAAKHALIGMMETTEQKDASVSCPPSPAPSPAPPVRAVISQPKYVSWLNEHSQKNKLSLKALEGARVGPNNTSQCCRYVVGEKEYPEGFGNTKKEAKEEAAMQVYLELCGGSQTTGTVDENCNGTTGKHKEELNGKVVVLSEKVEHMNMSPAQNVPEQYSFITTEETNFIGILNHYCQKTKRFLDFKLVEKSGPSHNPQFVYKVLIDKREYPDGLGKTAKEAKQQAAQLAWSALQEQSDWNSQVSCRSTVSEEGGLSSLTPSSTWESQDATPSSLSIAGSTSESIIFSDSVNVSSPKDESPVNVKPKIRLAANFQMSPVKTKQEGPNLKGNDLGTLSSGRTSNQPVISRFSSEFDSIENIGKGGFGHVYKARRKLEQKYFAVKIVRSKGKAKREVGALADLQHPNIVRYYTAWLEDTAYRCDTASESDTTSDSGSSSSSEFLYIQMELCDKRTLKVWIDERNAHRKPKRREESLSITQQIVNGVEYIHSKKLLHRDLKPANIMFGMSDGEGKGEVKIGDFGLVTAEDNDNDENLLERTKKTGTVSYMAPEQRNQTSYDRKVDIFALGLIYFEPLWDLSGMEKAKVWNDVRSQRFPQQFNSQFTLENKVIESLLCANPEERPDARQLKTKLNECSRVLTRVHNIHQDNRTI,negative +GACCGGUGUGUCCUGAUCCAACUGCCACAAGUACCAUAUGCAGGUGACGU,MKKRKVLIPLMALSTILVSSTGNLEVIQAEVKQENRLLNESESSSQGLLGYYFSDLNFQAPMVVTSSTTGDLSIPSSELENIPSENQYFQSAIWSGFIKVKKSDEYTFATSADNHVTMWVDDQEVINKASNSNKIRLEKGRLYQIKIQYQRENPTEKGLDFKLYWTDSQNKKEVISSDNLQLPELKQKSSNSRKKRSTSAGPTVPDRDNDGIPDSLEVEGYTVDVKNKRTFLSPWISNIHEKKGLTKYKSSPEKWSTASDPYSDFEKVTGRIDKNVSPEARHPLVAAYPIVHVDMENIILSKNEDQSTQNTDSQTRTISKNTSTSRTHTSEVHGNAEVHASFFDIGGSVSAGFSNSNSSTVAIDHSLSLAGERTWAETMGLNTADTARLNANIRYVNTGTAPIYNVLPTTSLVLGKNQTLATIKAKENQLSQILAPNNYYPSKNLAPIALNAQDDFSSTPITMNYNQFLELEKTKQLRLDTDQVYGNIATYNFENGRVRVDTGSNWSEVLPQIQETTARIIFNGKDLNLVERRIAAVNPSDPLETTKPDMTLKEALKIAFGFNEPNGNLQYQGKDITEFDFNFDQQTSQNIKNQLAELNATNIYTVLDKIKLNAKMNILIRDKRFHYDRNNIAVGADESVVKEAHREVINSSTEGLLLNIDKDIRKILSGYIVEIEDTEGLKEVINDRYDMLNISSLRQDGKTFIDFKKYNDKLPLYISNPNYKVNVYAVTKENTIINPSENGDTSTNGIKKILIFSKKGYEIG,negative +CCAAGGGCUAAGUCCGCAAAUAUCCUUCCUAAAGGACUCGUUACGUCGG,MHGDTPTLHEYMLDLQPETTDLYCYEQLNDSSEEEDEIDGPAGQAEPDRAHYNIVTFCCKCDSTLRLCVQSTHVDIRTLEDLLMGTLGIVCPICSQKP,negative +AAAACCUACAACACACCCCUCAACUUUCCC,MKKRKVLIPLMALSTILVSSTGNLEVIQAEVKQENRLLNESESSSQGLLGYYFSDLNFQAPMVVTSSTTGDLSIPSSELENIPSENQYFQSAIWSGFIKVKKSDEYTFATSADNHVTMWVDDQEVINKASNSNKIRLEKGRLYQIKIQYQRENPTEKGLDFKLYWTDSQNKKEVISSDNLQLPELKQKSSNSRKKRSTSAGPTVPDRDNDGIPDSLEVEGYTVDVKNKRTFLSPWISNIHEKKGLTKYKSSPEKWSTASDPYSDFEKVTGRIDKNVSPEARHPLVAAYPIVHVDMENIILSKNEDQSTQNTDSQTRTISKNTSTSRTHTSEVHGNAEVHASFFDIGGSVSAGFSNSNSSTVAIDHSLSLAGERTWAETMGLNTADTARLNANIRYVNTGTAPIYNVLPTTSLVLGKNQTLATIKAKENQLSQILAPNNYYPSKNLAPIALNAQDDFSSTPITMNYNQFLELEKTKQLRLDTDQVYGNIATYNFENGRVRVDTGSNWSEVLPQIQETTARIIFNGKDLNLVERRIAAVNPSDPLETTKPDMTLKEALKIAFGFNEPNGNLQYQGKDITEFDFNFDQQTSQNIKNQLAELNATNIYTVLDKIKLNAKMNILIRDKRFHYDRNNIAVGADESVVKEAHREVINSSTEGLLLNIDKDIRKILSGYIVEIEDTEGLKEVINDRYDMLNISSLRQDGKTFIDFKKYNDKLPLYISNPNYKVNVYAVTKENTIINPSENGDTSTNGIKKILIFSKKGYEIG,negative +TCCGGCGCGCTGAGTGCCGGTTTATCCTCGT,MKKRKVLIPLMALSTILVSSTGNLEVIQAEVKQENRLLNESESSSQGLLGYYFSDLNFQAPMVVTSSTTGDLSIPSSELENIPSENQYFQSAIWSGFIKVKKSDEYTFATSADNHVTMWVDDQEVINKASNSNKIRLEKGRLYQIKIQYQRENPTEKGLDFKLYWTDSQNKKEVISSDNLQLPELKQKSSNSRKKRSTSAGPTVPDRDNDGIPDSLEVEGYTVDVKNKRTFLSPWISNIHEKKGLTKYKSSPEKWSTASDPYSDFEKVTGRIDKNVSPEARHPLVAAYPIVHVDMENIILSKNEDQSTQNTDSQTRTISKNTSTSRTHTSEVHGNAEVHASFFDIGGSVSAGFSNSNSSTVAIDHSLSLAGERTWAETMGLNTADTARLNANIRYVNTGTAPIYNVLPTTSLVLGKNQTLATIKAKENQLSQILAPNNYYPSKNLAPIALNAQDDFSSTPITMNYNQFLELEKTKQLRLDTDQVYGNIATYNFENGRVRVDTGSNWSEVLPQIQETTARIIFNGKDLNLVERRIAAVNPSDPLETTKPDMTLKEALKIAFGFNEPNGNLQYQGKDITEFDFNFDQQTSQNIKNQLAELNATNIYTVLDKIKLNAKMNILIRDKRFHYDRNNIAVGADESVVKEAHREVINSSTEGLLLNIDKDIRKILSGYIVEIEDTEGLKEVINDRYDMLNISSLRQDGKTFIDFKKYNDKLPLYISNPNYKVNVYAVTKENTIINPSENGDTSTNGIKKILIFSKKGYEIG,negative +GAGCGGUUAAGGGAGAUUUAGGCAGCAGCUUGGACAGUGUAUCGGCUGAG,PHITDVVLDKANKTPLRQLDPSRLPDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFAKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRQSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPINRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDTASEATRPATLNRFSALQQTLPAENTDNRRVVQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRTRTPATKRSFSKEVEERSRERPSQPEGLRKAASLTEDRGRDPVKREATLPPVSPPKAALSVDEVEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRLGIESTLERSTIAREHMGRLLHQLLCAGHLSTAQYYQGLYETLELAEDMEIDIPHVWLYLAELITPILQEDGVPMGELFREITKPLRPMGKATSLLLEILGLLCKSMGPKKVGMLWREAGLSWREFLAEGQDVGSFVAEKKVEYTLGEESEAPGQRTLAFEELRRQLEKLLKDGGSNQRVFDWIDANLNEQQIASNTLVRALMTTVCYSAIIFETPLRVDVQVLKVRARLLQKYLCDEQKELQALYALQALVVTLEQPANLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFNWLREAEDEESDHN,negative +CCACAGTACTACCGTATAACATGATGTCAA,PGGVQVSLLKEYYEDGYHIVRDIDSTVGVSISDASLPPRTWNGFLAPKTYKNVYIDTYHNQVFDDIFRTFTIDQHVKLACSLPHGRLRGADKPLIVKEWSGAMTDCAMYLNGRGIGSRFDGSFPSGKPSGACGARSKGSSSELSAQQKKDTLRYIEAQLDAFEVGAGWYFWTW,negative +CCTTCGTTGTCTGCCTTCGTAGCGGATCGAATTACGCGTTAACGGCAACCGATAACGGGACCGATTGCACACCCTTCAGAATTCGCACCA,MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICEVEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASSIVYKKEGEQVEFSFPLAFTVEKLTGSGELWWQAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLPQALPQYAGSGNLTLALEAKTGKLHQEVNLVVMRATQLQKNLTCEVWGPTSPKLMLSLKLENKEAKVSKREKAVWVLNPEAGMWQCLLSDSGQVLLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQAERMSQIKRLLSEKKTCQCPHRFQKTCSPI,negative +GGGAGAGCGGAAGCGUGCUGGGCCGGAGUUGAGGCGUAGAUGGUUCAGAUCCGAACGAUGAAGCAUAACCCAGAGGUCGAUGGAUCC,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,negative +GGCUUAGCUAAACGUAGCGGGUAUCGAACGCGAGCGGCAUGCCGAUAUCAUGAGUAGCCGUGAUAGCAUGCUGCUCGGAUAAGCA,WPLTEEKIKALVEICXEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEEFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDXIIYQYMDDLYVGSDLEIGQHRTKVEELRQHLLXWGFTTPDKKHQKEPPFLWMGYELHP,negative +CTTCTGCCCGCCTCCTTCCGTGGGGATGCCATTGGTCCACAGGGTTATGGGAGCATCAGGAGACGAGATAGGCGGACACT,MNRPHSCLSFCWMYFAASGIRAVETANGKYAQKLFSDLFEDYSSALRPVEDTDAVLNVTLQVTLSQIKDMDERNQILTAYLWIRQTWHDAYLTWDRDQYDRLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDSPAITKSSCVVDVTYFPFDSQQCNLTFGSWTYNGNQVDIFNALDSGDLSDFIEDVEWEVHGMPAVKNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGEKVSLGVTILLAMTVFQLMVAEIMPASENVPLIGKYYIATMALITASTALTIMVMNIHFCGAEARPVPHWAKVVILKYMSRILFVYDVGESCLSPRHSQEPEQVTKVYSKLPESNLKTSRNKDLSRKKEVRKLLKNDLGYQGGIPQNTDSYCARYEALTKNIEYIAKCLKDHKATNSKGSEWKKVAKVIDRFFMWIFFAMVFVMTVLIIARAD,negative +ACTCGAACATTTCCACTAACCAACCATACTAAAGCACCGC,MKKRKVLIPLMALSTILVSSTGNLEVIQAEVKQENRLLNESESSSQGLLGYYFSDLNFQAPMVVTSSTTGDLSIPSSELENIPSENQYFQSAIWSGFIKVKKSDEYTFATSADNHVTMWVDDQEVINKASNSNKIRLEKGRLYQIKIQYQRENPTEKGLDFKLYWTDSQNKKEVISSDNLQLPELKQKSSNSRKKRSTSAGPTVPDRDNDGIPDSLEVEGYTVDVKNKRTFLSPWISNIHEKKGLTKYKSSPEKWSTASDPYSDFEKVTGRIDKNVSPEARHPLVAAYPIVHVDMENIILSKNEDQSTQNTDSQTRTISKNTSTSRTHTSEVHGNAEVHASFFDIGGSVSAGFSNSNSSTVAIDHSLSLAGERTWAETMGLNTADTARLNANIRYVNTGTAPIYNVLPTTSLVLGKNQTLATIKAKENQLSQILAPNNYYPSKNLAPIALNAQDDFSSTPITMNYNQFLELEKTKQLRLDTDQVYGNIATYNFENGRVRVDTGSNWSEVLPQIQETTARIIFNGKDLNLVERRIAAVNPSDPLETTKPDMTLKEALKIAFGFNEPNGNLQYQGKDITEFDFNFDQQTSQNIKNQLAELNATNIYTVLDKIKLNAKMNILIRDKRFHYDRNNIAVGADESVVKEAHREVINSSTEGLLLNIDKDIRKILSGYIVEIEDTEGLKEVINDRYDMLNISSLRQDGKTFIDFKKYNDKLPLYISNPNYKVNVYAVTKENTIINPSENGDTSTNGIKKILIFSKKGYEIG,negative +CTTCGGCTTCACAGCTTTGGAAAGGGTACAAATTAAACTA,MKRASAGGSRLLAWVLWLQAWQVAAPCPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDNPWVCDCRARPLWAWLQKFRGSSSEVPCSLPQRLAGRDLKRLAANDLQGCAVATGPYHPIWTGRATDEEPLGLPKCCQPDAADKASVLEPGRPASAGNALKGRVPPGDSPPGNGSGPRHINDSPFGTLPGSAEPPLTAVRPEGSEPPGFPTSGPRRRPGCSRKNRTRSHCRLGQAGSGGGGTGDSEGSGALPSLTCSLTPLGLALVLWTVLGPC,negative +AATATCCCCCCTTCGGTGCAAAGCACCGAAGGGGGGA,GRQVDIDGEDYQRRDSIAQLLEDWGLIVIEDSAREDLFGLTNNFRVISFKQKDDWTLKAKYTIGN,negative +GGGAAAAUAAUAAUAAA,IMEIRTVAVGIVAIKGVESEYYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHSGGEMFVALNQKGLPVKGKKTKKEQKTAHFLPMAIT,negative +AUCAGUCCCCACUGCCCCCGCUUGCAGACA,MSSTESPVPAAAAPAEAVPASTPAPAAEQPAVGNGEQRNNADAANNTSLYVGELDPSVTEAMLFEIFSMIGTVASIRVCRDAVTRRSLGYAYVNFLNAADGERAMEQLNYSLIRNRPCRIMWSQRDPALRRTGQGNIFIKNLDAGIDNKALHDTFAAFGNILSCKVATNETGSLGYGFVHYETAEAAEAAIKHVNGMLLNDKKVYVGHHIPRKERQAKIEETRANFTNVYAKNVDPEVTDDEFEKLFTKFGKITSCVLQRDEDGKSKGFGFVNFEDHNEAQKAVDELHDSDFKGQKLFVARAQKKSEREEELRRSYEAAKNEKLAKFQGVNLYLKNIPESYDDERLREEFAPFGAITSCKIMRAPSGVSRGFGFVCYSAPEEANKAVSEMNGKMLDNRPLYVALAQRKDVRRQQLEAQIMQRNQLRLQQQAAAQGMGYPGPGMYYPQPGAFPGQPGGMVPRPRYAPAGMMPQGMPMAPYGQPGQFPAGMMPQGYRPARPPRGAPNAAGGPAPPAGARPPTGVNGAPRPAGQPVPGQPMPRGPAARPAGRPEADQPGALTAAALAKASPEEQKQMLGEAIYPKVAASQPELAGKLTGMILELPVTELLHLLEESEALDAKVNEALEVLKEYQQNDSAGAEAEANAEAPKTEA,negative +GCUAUCAUCAUUAACUUUAUUUAUUACCGUCAUUCAUUUCUGAAUGUCUGUUUACCCCUAUUUCAACCGGUUUUUUUU,MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPGPHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR,negative +CGGAATTCCGAGCGTGGGCGTGAGCCCTAAACACAAGTCCGCAGGGGTGTGGTAATATTCGCAGTTGTGTGTACGCCCACGCTCGAG,MKPGGNTIVIWMYAVATWLCFGSTSGWSFTLEDNNIFPKQYPIINFTTAGATVQSYTNFIRAVRGRLTTGADVRHEIPVLPNRVGLPINQRFILVELSNHAELSVTLALDVTNAYVVGYRAGNSAYFFHPDNQEDAEAITHLFTDVQNRYTFAFGGNYDRLEQLAGNLRENIELGNGPLEEAISALYYYSTGGTQLPTLARSFIICIQMISEAARFQYIEGEMRTRIRYNRRSAPDPSVITLENSWGRLSTAIQESNQGAFASPIQLQRRNGSKFSVYDVSILIPIIALMVYRCAPPPSSQFSLLIRPVVPNFNADVCMDPEPIVRIVGRNGLCVDVRDGRFHNGNAIQLWPCKSNTDANQLWTLKRDNTIRSNGKCLTTYGYSPGVYVMIYDCNTAATDATRWQIWDNGTIINPRSSLVLAATSGNSGTTLTVQTNIYAVSQGWLPTNNTQPFVTTIVGLYGLCLQANSGQVWIEDCSSEKAEQQWALYADGSIRPQQNRDNCLTSDSNIRETVVKILSCGPASSGQRWMFKNDGTILNLYSGLVLDVRASDPSLKQIILYPLHGDPNQIWLPLF,negative +TCTCATGCGTCGAGTGTGAGTTTACCTTCGT,MKPGGNTIVIWMYAVATWLCFGSTSGWSFTLEDNNIFPKQYPIINFTTAGATVQSYTNFIRAVRGRLTTGADVRHEIPVLPNRVGLPINQRFILVELSNHAELSVTLALDVTNAYVVGYRAGNSAYFFHPDNQEDAEAITHLFTDVQNRYTFAFGGNYDRLEQLAGNLRENIELGNGPLEEAISALYYYSTGGTQLPTLARSFIICIQMISEAARFQYIEGEMRTRIRYNRRSAPDPSVITLENSWGRLSTAIQESNQGAFASPIQLQRRNGSKFSVYDVSILIPIIALMVYRCAPPPSSQFSLLIRPVVPNFNADVCMDPEPIVRIVGRNGLCVDVRDGRFHNGNAIQLWPCKSNTDANQLWTLKRDNTIRSNGKCLTTYGYSPGVYVMIYDCNTAATDATRWQIWDNGTIINPRSSLVLAATSGNSGTTLTVQTNIYAVSQGWLPTNNTQPFVTTIVGLYGLCLQANSGQVWIEDCSSEKAEQQWALYADGSIRPQQNRDNCLTSDSNIRETVVKILSCGPASSGQRWMFKNDGTILNLYSGLVLDVRASDPSLKQIILYPLHGDPNQIWLPLF,negative +GGGCGAAUUCGAGCCUCAAGACGUCGGGGAUUGGCAAACCCCGUUUCCUUGAGCGACCCCCUGUUACUCGGCGGAUCCUCU,MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNLERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCPFGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGRVSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVFHKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVEGTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT,negative +GGGAGAGGAGAGAACGUUCUACAGCGCCGGUGGGCGGGCAUUGGGUGGAUGCGCUGUCGAUCGAUCGAUCGAUG,MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP,negative +GATGTGGGTGTAGTTGGAGGGTAAACGTT,MPSNQEARLFLAVLVLAQVLPILVDSAAEKGFKQAFWQPLCQVSEELDDQPKGALFTLQAAASKIQKMRDAALRASIYAEINHGTNRAKAAVIVANHYAMKADSGLEALKQTLSSQEVTATATASYLKGRIDEYLNLLLQTKESGTSGCMMDTSGTNTVTKAGGTIGGVPCKLQLSPIQPKRPAATYLGKAGYVGLTRQADAANNFHDNDAECRLASGHNTNGLGKSGQLSAAVTMAAGYVTVANSQTAVTVQALDALQEASGAAHQPWIDAWKAKKALTGAETAEFRNETAGIAGKTGVTKLVEEALLKKKDSEASEIQTELKKYFSGHENEQWTAIEKLISEQPVAQNLVGDNQPTKLGELEGNAKLTTILAYYRMETAGKFEVLTQKHKPAESQQQAAETEGSCNKKDQNECKSPCKWHNDAENKKCTLDKEEAKKVADETAKDGKTGNTNTTGSSNSFVISKTPLWLAVLLF,negative +AAGACGGCCGGGGAAACCCGAGGUCCGAUGUAACGC,MDSTNYISKLFEYAQRQGQISDIKFEEVGTDGPDHLKTFTLRVVIKGHAYPNGVGKTKKEAKRNAAKHALIGMMETTEQKDASVSCPPSPAPSPAPPVRAVISQPKYVSWLNEHSQKNKLSLKALEGARVGPNNTSQCCRYVVGEKEYPEGFGNTKKEAKEEAAMQVYLELCGGSQTTGTVDENCNGTTGKHKEELNGKVVVLSEKVEHMNMSPAQNVPEQYSFITTEETNFIGILNHYCQKTKRFLDFKLVEKSGPSHNPQFVYKVLIDKREYPDGLGKTAKEAKQQAAQLAWSALQEQSDWNSQVSCRSTVSEEGGLSSLTPSSTWESQDATPSSLSIAGSTSESIIFSDSVNVSSPKDESPVNVKPKIRLAANFQMSPVKTKQEGPNLKGNDLGTLSSGRTSNQPVISRFSSEFDSIENIGKGGFGHVYKARRKLEQKYFAVKIVRSKGKAKREVGALADLQHPNIVRYYTAWLEDTAYRCDTASESDTTSDSGSSSSSEFLYIQMELCDKRTLKVWIDERNAHRKPKRREESLSITQQIVNGVEYIHSKKLLHRDLKPANIMFGMSDGEGKGEVKIGDFGLVTAEDNDNDENLLERTKKTGTVSYMAPEQRNQTSYDRKVDIFALGLIYFEPLWDLSGMEKAKVWNDVRSQRFPQQFNSQFTLENKVIESLLCANPEERPDARQLKTKLNECSRVLTRVHNIHQDNRTI,negative +TAGGGAATTTCGACGGATCCAGCUGAUGUGGGACGUCAGUUAUAGGAAUGUGGAGGUUGGAAGUUAUGGCUUGCAUCAGCTGCAGGTCGACGCATGCGCCG,MHGDTPTLHEYMLDLQPETTDLYCYEQLNDSSEEEDEIDGPAGQAEPDRAHYNIVTFCCKCDSTLRLCVQSTHVDIRTLEDLLMGTLGIVCPICSQKP,negative +CCUGCCCUUUCCAACACCCGCCGAAACUCA,MKKRKVLIPLMALSTILVSSTGNLEVIQAEVKQENRLLNESESSSQGLLGYYFSDLNFQAPMVVTSSTTGDLSIPSSELENIPSENQYFQSAIWSGFIKVKKSDEYTFATSADNHVTMWVDDQEVINKASNSNKIRLEKGRLYQIKIQYQRENPTEKGLDFKLYWTDSQNKKEVISSDNLQLPELKQKSSNSRKKRSTSAGPTVPDRDNDGIPDSLEVEGYTVDVKNKRTFLSPWISNIHEKKGLTKYKSSPEKWSTASDPYSDFEKVTGRIDKNVSPEARHPLVAAYPIVHVDMENIILSKNEDQSTQNTDSQTRTISKNTSTSRTHTSEVHGNAEVHASFFDIGGSVSAGFSNSNSSTVAIDHSLSLAGERTWAETMGLNTADTARLNANIRYVNTGTAPIYNVLPTTSLVLGKNQTLATIKAKENQLSQILAPNNYYPSKNLAPIALNAQDDFSSTPITMNYNQFLELEKTKQLRLDTDQVYGNIATYNFENGRVRVDTGSNWSEVLPQIQETTARIIFNGKDLNLVERRIAAVNPSDPLETTKPDMTLKEALKIAFGFNEPNGNLQYQGKDITEFDFNFDQQTSQNIKNQLAELNATNIYTVLDKIKLNAKMNILIRDKRFHYDRNNIAVGADESVVKEAHREVINSSTEGLLLNIDKDIRKILSGYIVEIEDTEGLKEVINDRYDMLNISSLRQDGKTFIDFKKYNDKLPLYISNPNYKVNVYAVTKENTIINPSENGDTSTNGIKKILIFSKKGYEIG,negative +UGGGGUAUCGCCAAAAGAAAGGCACCGGAUUCUGAUUCCGGAGGUCGAGAUUGUCGUCCUCGUACCCCAGCCA,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,negative +ATTGACCGCTGTGTGACGCAACACTCAAT,MASNFTQFVLVDNGGTGDVTVAPSNFANGVAEWISSNSRSQAYKVTCSVRQSSAQNRKYTIKVEVPKVATQTVGGVELPVAAWRSYLNMELTIPIFATNSDCELIVKAMQGLLKDGNPIPSAIAANSGIY,negative +CAUGUCUACAACAAUCUCGCCCGUUGAGUCUCGUCGAAUU,MVKSHIGSWILVLFVAMWSDVGLCKKRPKPGGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGTHGQWNKPSKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGSDYEDRYYRENMHRYPNQVYYRPVDQYSNQNNFVHDCVNITVKEHTVTTTTKGENFTETDIKMMERVVEQMCITQYQRESQAYYQRGASVILFSSPPVILLISFLIFLIVG,negative +GGGAGGGAAUCAGUGAAUGCUUAUACAUCCCUCCUUGAGCAGUCGAUUAGUUUCGACAGGAGGCUCAC,MGLLGILCFLIFLGKTWGQEQTYVISAPKIFRVGASENIVIQVYGYTEAFDATISIKSYPDKKFSYSSGHVHLSSENKFQNSAILTIQPKQLPGGQNPVSYVYLEVVSKHFSKSKRMPITYDNGFLFIHTDKPVYTPDQSVKVRVYSLNDDLKPAKRETVLTFIDPEGSEVDMVEEIDHIGIISFPDFKIPSNPRYGMWTIKAKYKEDFSTTGTAYFEVKEYVLPHFSVSIEPEYNFIGYKNFKNFEITIKARYFYNKVVTEADVYITFGIREDLKDDQKEMMQTAMQNTMLINGIAQVTFDSETAVKELSYYSLEDLNNKYLYIAVTVIESTGGFSEEAEIPGIKYVLSPYKLNLVATPLFLKPGIPYPIKVQVKDSLDQLVGGVPVTLNAQTIDVNQETSDLDPSKSVTRVDDGVASFVLNLPSGVTVLEFNVKTDAPDLPEENQAREGYRAIAYSSLSQSYLYIDWTDNHKALLVGEHLNIIVTPKSPYIDKITHYNYLILSKGKIIHFGTREKFSDASYQSINIPVTQNMVPSSRLLVYYIVTGEQTAELVSDSVWLNIEEKCGNQLQVHLSPDADAYSPGQTVSLNMATGMDSWVALAAVDSAVYGVQRGAKKPLERVFQFLEKSDLGCGAGGGLNNANVFHLAGLTFLTNANADDSQENDEPCKEILRPRRTLQKKIEEIAAKYKHSVVKKCCYDGACVNNDETCEQRAARISLGPRCIKAFTECCVVASQLRANISHKDMQLGRLHMKTLLPVSKPEIRSYFPESWLWEVHLVPRRKQLQFALPDSLTTWEIQGVGISNTGICVADTVKAKVFKDVFLEMNIPYSVVRGEQIQLKGTVYNYRTSGMQFCVKMSAVEGICTSESPVIDHQGTKSSKCVRQKVEGSSSHLVTFTVLPLEIGLHNINFSLETWFGKEILVKTLRVVPEGVKRESYSGVTLDPRGIYGTISRRKEFPYRIPLDLVPKTEIKRILSVKGLLVGEILSAVLSQEGINILTHLPKGSAEAELMSVVPVFYVFHYLETGNHWNIFHSDPLIEKQKLKKKLKEGMLSIMSYRNADYSYSVWKGGSASTWLTAFALRVLGQVNKYVEQNQNSICNSLLWLVENYQLDNGSFKENSQYQPIKLQGTLPVEARENSLYLTAFTVIGIRKAFDICPLVKIDTALIKADNFLLENTLPAQSTFTLAISAYALSLGDKTHPQFRSIVSALKREALVKGNPPIYRFWKDNLQHKDSSVPNTGTARMVETTAYALLTSLNLKDINYVNPVIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVKQLRLSMDIDVSYKHKGALHNYKMTDKNFLGRPVEVLLNDDLIVSTGFGSGLATVHVTTVVHKTSTSEEVCSFYLKIDTQDIEASHYRGYGNSDYKRIVACASYKPSREESSSGSSHAVMDISLPTGISANEEDLKALVEGVDQLFTDYQIKDGHVILQLNSIPSSDFLCVRFRIFELFEVGFLSPATFTVYEYHRPDKQCTMFYSTSNIKIQKVCEGAACKCVEADCGQMQEELDLTISAETRKQTACKPEIAYAYKVSITSITVENVFVKYKATLLDIYKTGEAVAEKDSEITFIKKVTCTNAELVKGRQYLIMGKEALQIKYNFSFRYIYPLDSLTWIEYWPRDTTCSSCQAFLANLDEFAEDIFLNGC,negative +AAGACGGCCGGGGAAACCCGAGAUCCGAGGUAACGC,MAAKVASTSSEEAEGSLVTEGEMGEKALPVVYKRYICSFADCGAAYNKNWKLQAHLCKHTGEKPFPCKEEGCEKGFTSLHHLTRHSLTHTGEKNFTCDSDGCDLRFTTKANMKKHFNRFHNIKICVYVCHFENCGKAFKKHNQLKVHQFSHTQQLPYECPHEGCDKRFSLPSRLKRHEKVHAGYPCKKDDSCSFVGKTWTLYLKHVAECHQDLAVCDVCNRKFRHKDYLRDHQKTHEKERTVYLCPRDGCDRSYTTAFNLRSHIQSFHEEQRPFVCEHAGCGKCFAMKKSLERHSVVHDPEKRKLKEKCPRPKRSLASRLTGYIPPKSKEKNASVSGTEKTDSLVKNKPSGTETNGSLVLDKLTIQ,negative +CGAAAGUCUCACUUCCUAAUCCCCUUCUUC,MRANDALQVLGLLFSLARGSEVGNSQAVCPGTLNGLSVTGDAENQYQTLYKLYERCEVVMGNLEIVLTGHNADLSFLQWIREVTGYVLVAMNEFSTLPLPNLRVVRGTQVYDGKFAIFVMLNYNTNSSHALRQLRLTQLTEILSGGVYIEKNDKLCHMDTIDWRDIVRDRDAEIVVKDNGRSCPPCHEVCKGRCWGPGSEDCQTLTKTICAPQCNGHCFGPNPNQCCHDECAGGCSGPQDTDCFACRHFNDSGACVPRCPQPLVYNKLTFQLEPNPHTKYQYGGVCVASCPHNFVVDQTSCVRACPPDKMEVDKNGLKMCEPCGGLCPKACEGTGSGSRFQTVDSSNIDGFVNCTKILGNLDFLITGLNGDPWHKIPALDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSNLTTIGGRSLYNRGFSLLIMKNLNVTSLGFRSLKEISAGRIYISANRQLCYHHSLNWTKVLRGPTEERLDIKHNRPRRDCVAEGKVCDPLCSSGGCWGPGPGQCLSCRNYSRGGVCVTHCNFLNGEPREFAHEAECFSCHPECQPMEGTATCNGSGSDTCAQCAHFRDGPHCVSSCPHGVLGAKGPIYKYPDVQNECRPCHENCTQGCKGPELQDCLGQTLVLIGKTHLTMALTVIAGLVVIFMMLGGTFLYWRGRRIQNKRAMRRYLERGESIEPLDPSEKANKVLARIFKETELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANEFTRMARDPPRYLVIKRESGPGIAPGPEPHGLTNKKLEEVELEPELDLDLDLEAEEDNLATTTLGSALSLPVGTLNRPRGSQSLLSPSSGYMPMNQGNLGESCQESAVSGSSERCPRPVSLHPMPRGCLASESSEGHVTGSEAELQEKVSMCRSRSRSRSPRPRGDSAYHSQRHSLLTPVTPLSPPGLEEEDVNGYVMPDTHLKGTPSSREGTLSSVGLSSVLGTEEEDEDEEYEYMNRRRRHSPPHPPRPSSLEELGYEYMDVGSDLSASLGSTQSCPLHPVPIMPTAGTTPDEDYEYMNRQRDGGGPGGDYAAMGACPASEQGYEEMRAFQGPGHQAPHVHYARLKTLRSLEATDSAFDNPDYWHSRLFPKANAQRT,negative +UGGUCUCCCAAUUCUAAACUUUCUCCAUCGUAUCUGGG,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,negative +GGGGTTCCACCTTCACTGGGCGCGCCCAGTGAAGGTGGAACCCC,MAGRSGDSDEELLKAVRLIKFLYQSNPPPNPEGTRQARRNRRRRWRERQRQIHSISERILSTYLGRSAEPVPLQLPPLERLTLDCNEDCGTSGTQGVGSPQILVESPTILESGAKE,negative +AAAGAGCUAAUGUAGGAUGCUGGGGUAGUCCAGCCCUAGAAUAAGCGCUAGUACUACAAGCUUCUGGAGCUCGGU,MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH,negative +GGCUUAGCUAAACGUAGCGGGUAUCGAACGCGAGCGGCAUGCCGAUAUCAUGAGUAGCCGUGAUAGCAUGCUGCUCGGAUAAGCA,MASNFTQFVLVDNGGTGDVTVAPSNFANGVAEWISSNSRSQAYKVTCSVRQSSAQNRKYTIKVEVPKVATQTVGGVELPVAAWRSYLNMELTIPIFATNSDCELIVKAMQGLLKDGNPIPSAIAANSGIY,negative +CTAAGGATCGGATCCACGGCCTACCAGGTC,MKPGGNTIVIWMYAVATWLCFGSTSGWSFTLEDNNIFPKQYPIINFTTAGATVQSYTNFIRAVRGRLTTGADVRHEIPVLPNRVGLPINQRFILVELSNHAELSVTLALDVTNAYVVGYRAGNSAYFFHPDNQEDAEAITHLFTDVQNRYTFAFGGNYDRLEQLAGNLRENIELGNGPLEEAISALYYYSTGGTQLPTLARSFIICIQMISEAARFQYIEGEMRTRIRYNRRSAPDPSVITLENSWGRLSTAIQESNQGAFASPIQLQRRNGSKFSVYDVSILIPIIALMVYRCAPPPSSQFSLLIRPVVPNFNADVCMDPEPIVRIVGRNGLCVDVRDGRFHNGNAIQLWPCKSNTDANQLWTLKRDNTIRSNGKCLTTYGYSPGVYVMIYDCNTAATDATRWQIWDNGTIINPRSSLVLAATSGNSGTTLTVQTNIYAVSQGWLPTNNTQPFVTTIVGLYGLCLQANSGQVWIEDCSSEKAEQQWALYADGSIRPQQNRDNCLTSDSNIRETVVKILSCGPASSGQRWMFKNDGTILNLYSGLVLDVRASDPSLKQIILYPLHGDPNQIWLPLF,negative +AGUCAUUUAUAAGAUCCGACAACCUGUCUAUUAGUUGCGCCGAUUAAGUGACU,MHGDTPTLHEYMLDLQPETTDLYCYEQLNDSSEEEDEIDGPAGQAEPDRAHYNIVTFCCKCDSTLRLCVQSTHVDIRTLEDLLMGTLGIVCPICSQKP,negative +GGCGAAUUCAGGGGACGUAGCAAUGACUGCC,MRKIVVAAIAVSLTTVSITASASADPSKDSKAQVSAAEAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKVKPSAASIDAAKKAGVNNGNPLDAVQQ,negative +GGUAGAUACGAUGGAGGUGUAUUUUAUGUGCGUAUUUGGAGGCAUGACGCGCAGCCA,MELAAWCRWGFLLALLPPGIAGTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYVPANASLSFLQDIQEVQGYMLIAHNQVKRVPLQRLRIVRGTQLFEDKYALAVLDNRDPQDNVAASTPGRTPEGLRELQLRSLTEILKGGVLIRGNPQLCYQDMVLWKDVFRKNNQLAPVDIDTNRSRACPPCAPACKDNHCWGESPEDCQILTGTICTSGCARCKGRLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMHNPEGRYTFGASCVTTCPYNYLSTEVGSCTLVCPPNNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLRGARAITSDNVQEFDGCKKIFGSLAFLPESFDGDPSSGIAPLRPEQLQVFETLEEITGYLYISAWPDSLRDLSVFQNLRIIRGRILHDGAYSLTLQGLGIHSLGLRSLRELGSGLALIHRNAHLCFVHTVPWDQLFRNPHQALLHSGNRPEEDLCVSSGLVCNSLCAHGHCWGPGPTQCVNCSHFLRGQECVEECRVWKGLPREYVSDKRCLPCHPECQPQNSSETCFGSEADQCAACAHYKDSSSCVARCPSGVKPDLSYMPIWKYPDEEGICQPCPINCTHSCVDLDERGCPAEQRASPVTFIIATVVGVLLFLILVVVVGILIKRRRQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVREHRGRLGSQDLLNWCVQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPSSPMDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFSPDPTPGTGSTAHRRHRSSSTRSGGGELTLGLEPSEEGPPRSPLAPSEGAGSDVFDGDLAMGVTKGLQSLSPHDLSPLQRYSEDPTLPLPPETDGYVAPLACSPQPEYVNQSEVQPQPPLTPEGPLPPVRPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLVPREGTASPPHPSPAFSPAFDNLYYWDQNSSEQGPPPSNFEGTPTAENPEYLGLDVPV,negative +UGACGCGAUCCGCCGUUCCCAUCCGCACGCCCUACACCU,MAVAQELYGFPASKLDSFVAQWLQPTREWKEEVLETVQTVEQFLRQENFREDRGPARDVRVLKVLKVGCFGNGTVLRSTTDVELVVFLSCFHSFQEEAKHHQAVLRLIQKRMYYCQELMDLGLSNLSVTNRVPSSLIFTIQTRETWETITVTVVPAYRALGPSCPSSEVYANLIKANGYPGNFSPSFSELQRNFVKHRPTKLKSLLRLVKHWYQQYVRDKCPRANLPPLYALELLTVYAWEAGTREDANFRLDEGLATVMELLQDHELLCIYWTKHYTLQHPVIEACVRRQLRGQRPIILDPADPTNNVAEGYRWDIVAQRANQCLKQDCCYDNRDSPVPSWRVKRAPDIQVTVQEWGHSDLTFWVNPYEPIKKLKEKIQLSQGYLGLQRLSFQEPGGERQLIRSHCTLAYYGIFCDTHICLLDTISPEIQVFVKNPDGRSHAYAIHPLDYVLNLKQQIEDRQGLRCQEQRLEFQGHILEDWFDFKSYGIQDSVTVILSKTTEGAAPFVPS,negative +UAAGCUCUUUGGCUUAGCCCGACACGUUGAACUCCAGAGU,PGGVQVSLLKEYYEDGYHIVRDIDSTVGVSISDASLPPRTWNGFLAPKTYKNVYIDTYHNQVFDDIFRTFTIDQHVKLACSLPHGRLRGADKPLIVKEWSGAMTDCAMYLNGRGIGSRFDGSFPSGKPSGACGARSKGSSSELSAQQKKDTLRYIEAQLDAFEVGAGWYFWTW,negative +GGGGGGAGCAATATCTGTGTGTCAAAACCTAACGATGACT,PHITDVVLDKANKTPLRQLDPSRLPDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFAKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRQSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPINRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDTASEATRPATLNRFSALQQTLPAENTDNRRVVQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRTRTPATKRSFSKEVEERSRERPSQPEGLRKAASLTEDRGRDPVKREATLPPVSPPKAALSVDEVEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRLGIESTLERSTIAREHMGRLLHQLLCAGHLSTAQYYQGLYETLELAEDMEIDIPHVWLYLAELITPILQEDGVPMGELFREITKPLRPMGKATSLLLEILGLLCKSMGPKKVGMLWREAGLSWREFLAEGQDVGSFVAEKKVEYTLGEESEAPGQRTLAFEELRRQLEKLLKDGGSNQRVFDWIDANLNEQQIASNTLVRALMTTVCYSAIIFETPLRVDVQVLKVRARLLQKYLCDEQKELQALYALQALVVTLEQPANLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFNWLREAEDEESDHN,negative +TAGGGAATTTCGACGGATCCAGCUGAUGUGGGACGUCAGUUAUAGGAAUGUGGAGGUUGGAAGUUAUGGCUUGCAUCAGCTGCAGGTCGACGCATGCGCCG,MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPGPHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR,negative +CAGGTCAGTTCAGCGGATCCTGTCGAAAAACACACACCCCGAGGCGAATTCAGTGCAACTGCAGC,GRQVDIDGEDYQRRDSIAQLLEDWGLIVIEDSAREDLFGLTNNFRVISFKQKDDWTLKAKYTIGN,negative +TTGGGGAGGGGCACTGGGCAGTGTAATTTACGAAAGCGAG,WPLTEEKIKALVEICXEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEEFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDXIIYQYMDDLYVGSDLEIGQHRTKVEELRQHLLXWGFTTPDKKHQKEPPFLWMGYELHP,negative +GUAUAUAGUAUAGUAUUGGC,ASFTCLAIWALASAGVVPLVLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAAFFFVPVIISTVCYVSIIRCLSSSAVANRSKK,negative +ATACCAGTCTATTCAATTGGGCCCGTCCGTATGGTGGGTGTGCTGGCCAGATAGTATGTGCAATCA,MSARGEEAAGEASGSQEQPEPALAEPKKRGPGRPRKPQQEPTGEPVPKRPRGRPKGSKNKGPSKAAQKKAETTGEKRPRGRPRKWPQQVVQEKPAQEEEEEEEEEEAEED,negative +AATACCCGCCCTTCGGTGCAAAGCACCGAAGGGCGGG,MDHLNEATQGKEHSEMSNNVSDPKGPPAKIARLEQNGSPLGRGRLGSTGAKMQGVPLKHSGHLMKTNLRKGTMLPVFCVVEHYENAIEYDCKEEHAEFVLVRKDMLFNQLIEMALLSLGYSHSSAAQAKGLIQVGKWNPVPLSYVTDAPDATVADMLQDVYHVVTLKIQLHSCPKLEDLPPEQWSHTTVRNALKDLLKDMNQSSLAKECPLSQSMISSIVNSTYYANVSAAKCQEFGRWYKHFKKTKDMMVEMDSLSELSQQGANHVNFGQQPVPGNTAEQPPSPAQLSHGSQPSVRTPLPNLHPGLVSTPISPQLVNQQLVMAQLLNQQYAVNRLLAQQSLNQQYLNHPPPVSRSMNKPLEQQVSTNTEVSSEIYQWVRDELKRAGISQAVFARVAFNRTQGLLSEILRKEEDPKTASQSLLVNLRAMQNFLQLPEAERDRIYQDERERSLNAASAMGPAPLISTPPSRPPQVKTATIATERNGKPENNTMNINASIYDEIQQEMKRAKVSQALFAKVAATKSQGWLCELLRWKEDPSPENRTLWENLSMIRRFLSLPQPERDAIYEQESNAVHHHGDRPPHIIHVPAEQIQQQQQQQQQQQQQQQAPPPPQPQQQPQTGPRLPPRQPTVASPAESDEENRQKTRPRTKISVEALGILQSFIQDVGLYPDEEAIQTLSAQLDLPKYTIIKFFQNQRYYLKHHGKLKDNSGLEVDVAEYKEEELLKDLEESVQDKNTNTLFSVKLEEELSVEGNTDINTDLKD,negative +GTCTCAATACGCACCCTGCATTCCCTTACTCGAGCCTAGC,MASNFTQFVLVDNGGTGDVTVAPSNFANGVAEWISSNSRSQAYKVTCSVRQSSAQNRKYTIKVEVPKVATQTVGGVELPVAAWRSYLNMELTIPIFATNSDCELIVKAMQGLLKDGNPIPSAIAANSGIY,negative +TATTAGTAATACTATTAGTAATAC,PHITDVVLDKANKTPLRQLDPSRLPDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFAKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRQSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPINRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDTASEATRPATLNRFSALQQTLPAENTDNRRVVQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRTRTPATKRSFSKEVEERSRERPSQPEGLRKAASLTEDRGRDPVKREATLPPVSPPKAALSVDEVEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRLGIESTLERSTIAREHMGRLLHQLLCAGHLSTAQYYQGLYETLELAEDMEIDIPHVWLYLAELITPILQEDGVPMGELFREITKPLRPMGKATSLLLEILGLLCKSMGPKKVGMLWREAGLSWREFLAEGQDVGSFVAEKKVEYTLGEESEAPGQRTLAFEELRRQLEKLLKDGGSNQRVFDWIDANLNEQQIASNTLVRALMTTVCYSAIIFETPLRVDVQVLKVRARLLQKYLCDEQKELQALYALQALVVTLEQPANLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFNWLREAEDEESDHN,negative +ATACCAGTCTATTCAATTTGGCGGCGGGGGGGGAGCGGTTTCATCGTGAGATAGTATGTGCAATCA,MRKIVVAAIAVSLTTVSITASASADPSKDSKAQVSAAEAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKVKPSAASIDAAKKAGVNNGNPLDAVQQ,negative +UACCGAAAACGCAUGCCUCUAGCCGUUCGAUACGAGCUGAGCAGCGGGCCAGUACUACAAGCUUCUGGACUCGGU,MSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA,negative +UCGAUCACACAGUUCAAACGUAAUAAGCCAAUGUACGAGG,MDKLVVNYYEYKHPIINKDLAIGAHGGKKFPTLGAWYDVINEYEFQTRCPIILKNSHRNKHFTFACHLKNCPFKVLLSYAGNAASSETSSPSANNNTNPPGTPDHIHHHSNNMNNEDNDNNNGSNNKVSNDSKLDFVTDDLEYHLANTHPDDTNDKVESRSNEVNGNNDDDADANNIFKQQGVTIKNDTEDDSINKASIDRGLDDESGPTHGNDSGNHRHNEEDDVHTQMTKNYSDVVNDEDINVAIANAVANVDSQSNNKHDGKDDDATNNNDGQDNNTNNDHNNNSNINNNNVGSHGISSHSPSSIRDTSMNLDVFNSATDDIPGPFVVTKIEPYHSHPLEDNLSLGKFILTKIPKILQNDLKFDQILESSYNNSNHTVSKFKVSHYVEESGLLDILMQRYGLTAEDFEKRLLSQIARRITTYKARFVLKKKKMGEYNDLQPSSSSNNNNNNDGELSGTNLRSNSIDYAKHQEISSAGTSSNTTKNVNNNKNDSNDDNNGNNNNDASNLMESVLDKTSSHRYQPKKMPSVNKWSKPDQITHSDVSMVGLDESNDGGNENVHPTLAEVDAQEARETAQLAIDKINSYKRSIDDKNGDGHNNSSRNVVDENLINDMDSEDAHKSKRQHLSDITLEERNEDDKLPHEVAEQLRLLSSHLKEVENLHQNNDDDVDDVMVDVDVESQYNKNTTHHNNHHSQPHHDEEDVAGLIGKADDEEDLSDENIQPELRGQ,negative +AUCGCAUCUGAACCGGCCCAGCAGACUGCUGACGGCACGAU,MDSTNYISKLFEYAQRQGQISDIKFEEVGTDGPDHLKTFTLRVVIKGHAYPNGVGKTKKEAKRNAAKHALIGMMETTEQKDASVSCPPSPAPSPAPPVRAVISQPKYVSWLNEHSQKNKLSLKALEGARVGPNNTSQCCRYVVGEKEYPEGFGNTKKEAKEEAAMQVYLELCGGSQTTGTVDENCNGTTGKHKEELNGKVVVLSEKVEHMNMSPAQNVPEQYSFITTEETNFIGILNHYCQKTKRFLDFKLVEKSGPSHNPQFVYKVLIDKREYPDGLGKTAKEAKQQAAQLAWSALQEQSDWNSQVSCRSTVSEEGGLSSLTPSSTWESQDATPSSLSIAGSTSESIIFSDSVNVSSPKDESPVNVKPKIRLAANFQMSPVKTKQEGPNLKGNDLGTLSSGRTSNQPVISRFSSEFDSIENIGKGGFGHVYKARRKLEQKYFAVKIVRSKGKAKREVGALADLQHPNIVRYYTAWLEDTAYRCDTASESDTTSDSGSSSSSEFLYIQMELCDKRTLKVWIDERNAHRKPKRREESLSITQQIVNGVEYIHSKKLLHRDLKPANIMFGMSDGEGKGEVKIGDFGLVTAEDNDNDENLLERTKKTGTVSYMAPEQRNQTSYDRKVDIFALGLIYFEPLWDLSGMEKAKVWNDVRSQRFPQQFNSQFTLENKVIESLLCANPEERPDARQLKTKLNECSRVLTRVHNIHQDNRTI,negative +GCAATGGTACGGTACTTCCTGTGGCGAGGTAGGTGGGGTGTGTGTGTATCCAAAAGTGCACGCTACTTTGCTAA,WPLTEEKIKALVEICXEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEEFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDXIIYQYMDDLYVGSDLEIGQHRTKVEELRQHLLXWGFTTPDKKHQKEPPFLWMGYELHP,negative +CTTGCAAAATTTGCAACTGTGTG,MKKRKVLIPLMALSTILVSSTGNLEVIQAEVKQENRLLNESESSSQGLLGYYFSDLNFQAPMVVTSSTTGDLSIPSSELENIPSENQYFQSAIWSGFIKVKKSDEYTFATSADNHVTMWVDDQEVINKASNSNKIRLEKGRLYQIKIQYQRENPTEKGLDFKLYWTDSQNKKEVISSDNLQLPELKQKSSNSRKKRSTSAGPTVPDRDNDGIPDSLEVEGYTVDVKNKRTFLSPWISNIHEKKGLTKYKSSPEKWSTASDPYSDFEKVTGRIDKNVSPEARHPLVAAYPIVHVDMENIILSKNEDQSTQNTDSQTRTISKNTSTSRTHTSEVHGNAEVHASFFDIGGSVSAGFSNSNSSTVAIDHSLSLAGERTWAETMGLNTADTARLNANIRYVNTGTAPIYNVLPTTSLVLGKNQTLATIKAKENQLSQILAPNNYYPSKNLAPIALNAQDDFSSTPITMNYNQFLELEKTKQLRLDTDQVYGNIATYNFENGRVRVDTGSNWSEVLPQIQETTARIIFNGKDLNLVERRIAAVNPSDPLETTKPDMTLKEALKIAFGFNEPNGNLQYQGKDITEFDFNFDQQTSQNIKNQLAELNATNIYTVLDKIKLNAKMNILIRDKRFHYDRNNIAVGADESVVKEAHREVINSSTEGLLLNIDKDIRKILSGYIVEIEDTEGLKEVINDRYDMLNISSLRQDGKTFIDFKKYNDKLPLYISNPNYKVNVYAVTKENTIINPSENGDTSTNGIKKILIFSKKGYEIG,negative +GCGUGCAGUGCCUUCGGCCGTGCGGTGCCUCCGUCACGCT,LQENFLPQPRQQHHGTLVLHYRPHREEAGMQHPCLWPGSSHCSDDSTLRRLQCESVTSIGAVCP,negative +CAGCTCAGAAGCTTGATCCTGTGCGATCGAATGAAAGCTGCTGGATTGTCGCTATCCTGACTCGAAGTCGTGCATCTGCA,MSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEMLDRHHTHFCPLEGESWQDFLRNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAFLCQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERETPTTDSMPPLLRQAIELFDHQGAEPAFLFGLELIICGLEKQLKCESGS,negative +GAAGCUUUCACACAACAAGGCCCGGGACUGUAUUAGGGAAAUUAGAGUACAGACAGUCGCCGUGGGUCGAAUUCCGCUCA,MKKRKVLIPLMALSTILVSSTGNLEVIQAEVKQENRLLNESESSSQGLLGYYFSDLNFQAPMVVTSSTTGDLSIPSSELENIPSENQYFQSAIWSGFIKVKKSDEYTFATSADNHVTMWVDDQEVINKASNSNKIRLEKGRLYQIKIQYQRENPTEKGLDFKLYWTDSQNKKEVISSDNLQLPELKQKSSNSRKKRSTSAGPTVPDRDNDGIPDSLEVEGYTVDVKNKRTFLSPWISNIHEKKGLTKYKSSPEKWSTASDPYSDFEKVTGRIDKNVSPEARHPLVAAYPIVHVDMENIILSKNEDQSTQNTDSQTRTISKNTSTSRTHTSEVHGNAEVHASFFDIGGSVSAGFSNSNSSTVAIDHSLSLAGERTWAETMGLNTADTARLNANIRYVNTGTAPIYNVLPTTSLVLGKNQTLATIKAKENQLSQILAPNNYYPSKNLAPIALNAQDDFSSTPITMNYNQFLELEKTKQLRLDTDQVYGNIATYNFENGRVRVDTGSNWSEVLPQIQETTARIIFNGKDLNLVERRIAAVNPSDPLETTKPDMTLKEALKIAFGFNEPNGNLQYQGKDITEFDFNFDQQTSQNIKNQLAELNATNIYTVLDKIKLNAKMNILIRDKRFHYDRNNIAVGADESVVKEAHREVINSSTEGLLLNIDKDIRKILSGYIVEIEDTEGLKEVINDRYDMLNISSLRQDGKTFIDFKKYNDKLPLYISNPNYKVNVYAVTKENTIINPSENGDTSTNGIKKILIFSKKGYEIG,negative +AUUACCGGCGAGUUUUGAACCGCGUAAU,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +CCTTCGTTGTCTGCCTTCGTTAATCGGCTCGATTGATTCGAGGTGACGGTCGTTGGACGTGACGTTACGCACCCTTCAGAATTCGCACCA,GRQVDIDGEDYQRRDSIAQLLEDWGLIVIEDSAREDLFGLTNNFRVISFKQKDDWTLKAKYTIGN,negative +CGCGGATCCTGCAGCTCGAGTGGGTAAACAACAACATGTTGACATCGCGGCTCTAGAAGCTTGTCGAC,MDKLVVNYYEYKHPIINKDLAIGAHGGKKFPTLGAWYDVINEYEFQTRCPIILKNSHRNKHFTFACHLKNCPFKVLLSYAGNAASSETSSPSANNNTNPPGTPDHIHHHSNNMNNEDNDNNNGSNNKVSNDSKLDFVTDDLEYHLANTHPDDTNDKVESRSNEVNGNNDDDADANNIFKQQGVTIKNDTEDDSINKASIDRGLDDESGPTHGNDSGNHRHNEEDDVHTQMTKNYSDVVNDEDINVAIANAVANVDSQSNNKHDGKDDDATNNNDGQDNNTNNDHNNNSNINNNNVGSHGISSHSPSSIRDTSMNLDVFNSATDDIPGPFVVTKIEPYHSHPLEDNLSLGKFILTKIPKILQNDLKFDQILESSYNNSNHTVSKFKVSHYVEESGLLDILMQRYGLTAEDFEKRLLSQIARRITTYKARFVLKKKKMGEYNDLQPSSSSNNNNNNDGELSGTNLRSNSIDYAKHQEISSAGTSSNTTKNVNNNKNDSNDDNNGNNNNDASNLMESVLDKTSSHRYQPKKMPSVNKWSKPDQITHSDVSMVGLDESNDGGNENVHPTLAEVDAQEARETAQLAIDKINSYKRSIDDKNGDGHNNSSRNVVDENLINDMDSEDAHKSKRQHLSDITLEERNEDDKLPHEVAEQLRLLSSHLKEVENLHQNNDDDVDDVMVDVDVESQYNKNTTHHNNHHSQPHHDEEDVAGLIGKADDEEDLSDENIQPELRGQ,negative +GGUAGAUACGAUGGAGGUGUAUUUUAUGUGCGUAUUUGGAGGCAUGACGCGCAGCCA,MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP,negative +CCACCACCACAACAAAACTCCAC,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,negative +ACCCACCUACACCCCUCACCACACUACCAC,MPEEWVRIFGEAGITQFEQQRNPRLCLSVLNILSKSEHPQEKFMFVPYEQSALPVTDNSPFGDTSITHNYADHHFKASTPENEGSSFYSRVPGPCTVGVRSSSLSSGRGSSEGVGSRSGSGSGGAASRSSSSGHGGAGFPLPVTSVPANGRSSAPGPNSMTVTSGSHSSSGSNCSTGSLTGGMELTNTMVATTQRTGPNNVLVNGHSTGNHFHGGVTQRVAASAAPTECNVLPTYTGSSSSYQPTSFQSMAVHTPPAYTLRQIPPAHSIGYPYTSTAPTSESIILTAPTTTPSSTVYHTTQGSAIVKPLSDNQSQRDKLPYLMHKSQWHSNVTGHVPLSPGLPRRFVDGVLPPETSAHIQYSSGQSSPSPAGSATPVPTPRRESLAGSVPVRAGPAPPALATHELSSDANCTLTPPPVATRPEKTKSIYTKPVEAQCDGHLTIGDQQDASRRSLETPVPPQTAATIHGSENETRTNVTVLPTVHSDGNNSSVHAYQQATESRPLKPNTLERQGQKKVRPKISDEAIQEKLRMIVSIGDPNRKYQRQEKIGQGASGTVYGGIEVATGRRVAIKQMNLKQQPKKELIVNEIYVMKAKKHPNVVNYLDSYLVADELWVVMEYLDGGSLTEVVTETYMEEGQIAAVCRECLQALDFLHKNQVIHRDIKSDNILLGLDGSVKLTDFGFCAQLSSEQNKRSTMVGTPYWMAPEVVTRKQYGPKVDIWSLGIMAIEMLDGEPPYLNENPVRALYLIGTNGKPEIKERDKLSSEFQDFLDLCLEVKVERRATAQELLQHIFSRDGHRAMELLQTDNFHSSGVRKKRTPRLAIEKLVDPEVKRNYQNQLVECLPDGTVSDINGHWEKISKALLKPRRTVVMAAGEDELVVTVRGTSFNCPPTSLVEPNTGIIAPLIEPHHRGIGSYALEVVADIIGTLDYCGIAFLTMGSFVPYLYYSFYCVLWLKLFYLALIFALGSGAIAVSMSNTFASPAYRPLRALVFIALGLSGVIPCVHVTITNGFWPSLQHGSLGWLFLMAVLYITGASIYAVRVPERIFPGRFDIWFQSHQIFHVFVVAAALVHYHGIIGLTNYRLAIGDCRPPPGYPFPKHDYDNIELLRPFMTY,negative +GAAUCAAUACACAGUCCUGGGUGCUAACCAUGAACACCCAAGGCCUUAGUGGUGUGUGGUCCCUG,PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGKISKIGPENPYNTPVFAIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDESFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPXRXKNPEMVIYQYMDDLYVGSDLEIGQHRAKIEELRSHLLSWGFTTPDKKHQKEPPFLWMGYELHPDSWTVQPIELPEKDSWTVNE,negative +UUUUUUUAAUUUUUGUUUAUUAAUCUUUAUGCUUUUUUCAUUUAUCUAUAAUUUUUAUU,MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYTFLLPEMDNCRSSSSPYVSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQDNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVLVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF,negative +CACGGUACCACCAAGUCACACGUUGAACUCCAUGCAGCUG,WPLTEEKIKALVEICXEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEEFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDXIIYQYMDDLYVGSDLEIGQHRTKVEELRQHLLXWGFTTPDKKHQKEPPFLWMGYELHP,negative +GGGAGAAUUCAACUGCCAUCUAUAGAAGAUGAUGCCUGGAUACAAUACAGCCACUCCUCGACUGUAAACCGAGUCCAGAAGCUUGUAGU,MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM,negative +GGCGACCCCCGGGCTACCAGACAATGTACGCAGCAAGAGTGACGGTCGTACCTCGGAGTC,MGVLLTQRTLLSLVLALLFPSMASMAAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQGLDVPKLREHCRERPGAFPSEETLRGLGRRGFLQTLNATLGCVLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILGLRNNIYCMAQLLDNSDTAEPTKAGRGASQPPTPTPASDAFQRKLEGCRFLHGYHRFMHSVGRVFSKWGESPNRSRRHSPHQALRKGVRRTRPSRKGKRLMTRGQLPR,negative +GUAUUCUCGGUGGUUUAAUCAGAGUAGAGGAGGCUGACUCCUUUGGUUGGUCUACGUGGAGGUUCCUUUG,MSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA,negative +UUCCAUUGGAGUGGAACUGAGUUC,MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP,negative +GACCGGUGUGUCCUGAUCCAACUGCCACAAGUACCAUAUGCAGGUGACGU,MTPDIQAPFLSLLLLFPVLTVANVPTLTTSDSINPRRTTPVSTTQSSPTSSPTKETSWSTTTTLLTASSPAPSPAASPGHDGASTPTSSPAPSPAASPGHDGASTPTSSPAPSPAASPGHDGASTPTSSPAPSPAASPGHDGASTPTSSPAPSPAASPGHNGTSSPTGSPAPSPAASPGHDGASTPTSSPAPSPAASPGHNGTSSPTGSPAPSPAASPGHDGASTPTSSPAPSPAASPGHNGTSSPTGSPAPSPTASPGHDSAPSLTSSPAPSPTASPGQHGASSPTSSDTSSMTTRSMSSSMVTSAHKGTSSRATMTPVSKGTPSSVPSSETAPTAASHITRTAASSPSIALSTSSNPKTSQQLSVRVSLYFLSFRITNLQFNSSLENPQTSYYQELQRSIWGLILQIYKQRDFLGLSEIKFRPGSVVVELTLAFREGTTAEWVKAQFSQLEAHAASYNLTISGVSVYSAPFPSSAQAGSGVPGWGIALLVLVCVLVALAIIYLIALVVCQCGRKKCEQLDVFPTLDAYHPMSEYSTYHTHGRYVPPGSTKRSPYEEVSAGNGGSNLSYTNLAATSANL,negative +GGGGGAGGACGCGTAGTGGGGGGCCCATGGTTGTGTGG,MAITKINDCFELLSMVTYADKLKSLIKKEFSISFEEFAVLTYISENKEKEYYLKDIINHLNYKQPQVVKAVKILSQEDYFDKKRNEHDERTVLILVNAQQRKKIESLLSRVNKRITEANNEIEL,negative +GGUAGAUACGAUGGAGGUGUAUUUUAUGUGCGUAUUUGGAGGCAUGACGCGCAGCCA,MKPGGNTIVIWMYAVATWLCFGSTSGWSFTLEDNNIFPKQYPIINFTTAGATVQSYTNFIRAVRGRLTTGADVRHEIPVLPNRVGLPINQRFILVELSNHAELSVTLALDVTNAYVVGYRAGNSAYFFHPDNQEDAEAITHLFTDVQNRYTFAFGGNYDRLEQLAGNLRENIELGNGPLEEAISALYYYSTGGTQLPTLARSFIICIQMISEAARFQYIEGEMRTRIRYNRRSAPDPSVITLENSWGRLSTAIQESNQGAFASPIQLQRRNGSKFSVYDVSILIPIIALMVYRCAPPPSSQFSLLIRPVVPNFNADVCMDPEPIVRIVGRNGLCVDVRDGRFHNGNAIQLWPCKSNTDANQLWTLKRDNTIRSNGKCLTTYGYSPGVYVMIYDCNTAATDATRWQIWDNGTIINPRSSLVLAATSGNSGTTLTVQTNIYAVSQGWLPTNNTQPFVTTIVGLYGLCLQANSGQVWIEDCSSEKAEQQWALYADGSIRPQQNRDNCLTSDSNIRETVVKILSCGPASSGQRWMFKNDGTILNLYSGLVLDVRASDPSLKQIILYPLHGDPNQIWLPLF,negative +TCCCTACGGCGCTAACGGATCAAACATGCGCTCCAAGGAGTAGGGGCCACCGTGCTACAAC,MSGGDGRGHNTGAHSTSGNINGGPTGLGVGGGASDGSGWSSENNPWGGGSGSGIHWGGGSGHGNGGGNGNSGGGSGTGGNLSAVAAPVAFGFPALSTPGAGGLAVSISAGALSAAIADIMAALKGPFKFGLWGVALYGVLPSQIAKDDPNMMSKIVTSLPADDITESPVSSLPLDKATVNVNVRVVDDVKDERQNISVVSGVPMSVPVVDAKPTERPGVFTASIPGAPVLNISVNNSTPAVQTLSPGVTNNTDKDVRPAGFTQGGNTRDAVIRFPKDSGHNAVYVSVSDVLSPDQVKQRQDEENRRQQEWDATHPVEAAERNYERARAELNQANEDVARNQERQAKAVQVYNSRKSELDAANKTLADAIAEIKQFNRFAHDPMAGGHRMWQMAGLKAQRAQTDVNNKQAAFDAAAKEKSDADAALSSAMESRKKKEDKKRSAENNLNDEKNKPRKGFKDYGHDYHPAPKTENIKGLGDLKPGIPKTPKQNGGGKRKRWTGDKGRKIYEWDSQHGELEGYRASDGQHLGSFDPKTGNQLKGPDPKRNIKKYL,negative +GGGAGGACGATGCGGACTGAACCTAATTTGAAATTGGCTGGCGCGCATATTCCGTCAGACGACTCGCCCGA,QDRPIKFSTEGATSQSYKQFIEALRERLRGGLIHDIPVLPDPTTLQERNRYITVELSNSDTESIEVGIDVTNAYVVAYRAGTQSYFLRDAPSSASDYLFTGTDQHSLPFYGTYGDLERWAHQSRQQIPLGLQALTHGISFFRSGGNDNEEKARTLIVIIQMVAEAARFRYISNRVRVSIQTGTAFQPDAAMISLENNWDNLSRGVQESVQDTFPNQVTLTNIRNEPVIVDSLSHPTVAVLALMLFVCNPPNANQSPLLIRSIVEKSKICSSRYEPTVRIGGRDGMCVDVYDNGYHNGNRIIMWKCKDRLEENQLWTLKSDKTIRSNGKCLTTYGYAPGSYVMIYDCTSAVAEATYWEIWDNGTIINPKSALVLSAESSSMGGTLTVQTNEYLMRQGWRTGNNTSPFVTSISGYSDLCMQAQGSNVWMADCDSNKKEQQWALYTDGSIRSVQNTNNCLTSKDHKQGSTILLMGCSNGWASQRWVFKNDGSIYSLYDDMVMDVKGSDPSLKQIILWPYTGKPNQIWLTLF,negative +GGUGAUCGCACAGACACGGGCACUGAUGCGGCUCCCGUACAUAGGCCGGUAGUACUACAAGCUUCUGGACUCGGU,MDKLVVNYYEYKHPIINKDLAIGAHGGKKFPTLGAWYDVINEYEFQTRCPIILKNSHRNKHFTFACHLKNCPFKVLLSYAGNAASSETSSPSANNNTNPPGTPDHIHHHSNNMNNEDNDNNNGSNNKVSNDSKLDFVTDDLEYHLANTHPDDTNDKVESRSNEVNGNNDDDADANNIFKQQGVTIKNDTEDDSINKASIDRGLDDESGPTHGNDSGNHRHNEEDDVHTQMTKNYSDVVNDEDINVAIANAVANVDSQSNNKHDGKDDDATNNNDGQDNNTNNDHNNNSNINNNNVGSHGISSHSPSSIRDTSMNLDVFNSATDDIPGPFVVTKIEPYHSHPLEDNLSLGKFILTKIPKILQNDLKFDQILESSYNNSNHTVSKFKVSHYVEESGLLDILMQRYGLTAEDFEKRLLSQIARRITTYKARFVLKKKKMGEYNDLQPSSSSNNNNNNDGELSGTNLRSNSIDYAKHQEISSAGTSSNTTKNVNNNKNDSNDDNNGNNNNDASNLMESVLDKTSSHRYQPKKMPSVNKWSKPDQITHSDVSMVGLDESNDGGNENVHPTLAEVDAQEARETAQLAIDKINSYKRSIDDKNGDGHNNSSRNVVDENLINDMDSEDAHKSKRQHLSDITLEERNEDDKLPHEVAEQLRLLSSHLKEVENLHQNNDDDVDDVMVDVDVESQYNKNTTHHNNHHSQPHHDEEDVAGLIGKADDEEDLSDENIQPELRGQ,negative +UCUCUGGGCUCUUAGGAGAACGGAUAGGAGUGUGCUCGCU,MAAKVASTSSEEAEGSLVTEGEMGEKALPVVYKRYICSFADCGAAYNKNWKLQAHLCKHTGEKPFPCKEEGCEKGFTSLHHLTRHSLTHTGEKNFTCDSDGCDLRFTTKANMKKHFNRFHNIKICVYVCHFENCGKAFKKHNQLKVHQFSHTQQLPYECPHEGCDKRFSLPSRLKRHEKVHAGYPCKKDDSCSFVGKTWTLYLKHVAECHQDLAVCDVCNRKFRHKDYLRDHQKTHEKERTVYLCPRDGCDRSYTTAFNLRSHIQSFHEEQRPFVCEHAGCGKCFAMKKSLERHSVVHDPEKRKLKEKCPRPKRSLASRLTGYIPPKSKEKNASVSGTEKTDSLVKNKPSGTETNGSLVLDKLTIQ,negative +ACGAAACCUGCAGUCCUGCAAUGGGACAAG,MKQYLNTVISNPRPAQALGINQPFVVFCFITSRALSFVPAIYWCFKCLHLAFVADKFKWLPLTSALWTLVSAYLSFVLANGFLLKWLIHYSIGPTIIRLFSLNVINFSFLSLSVSFITHGDNAYLLPAWIAISCFQTAAYIVQDWITSPIIRTLPFRSSSSSSSNYRHNLDFLEITVFAVVPVGIASFFTMVMLIWQLYKYPDSFLVSA,negative +AATACGACTCACTATAGAGGGAGGACGATGCGGGGTGCTTCGAGCGTAGGAAGAAAGCCGGGGGCTGCAGATAATGTATAGCCAGACGACGGA,MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA,negative +GAAGGGACGAUAAAGAGGAAUCGAACAACAAGUGGCUGGC,PGGVQVSLLKEYYEDGYHIVRDIDSTVGVSISDASLPPRTWNGFLAPKTYKNVYIDTYHNQVFDDIFRTFTIDQHVKLACSLPHGRLRGADKPLIVKEWSGAMTDCAMYLNGRGIGSRFDGSFPSGKPSGACGARSKGSSSELSAQQKKDTLRYIEAQLDAFEVGAGWYFWTW,negative +CTCCTCTGACTGTAACCACGCAGGCCAATAACTAGCAGGTTACTGTTCATCATTTCGCACGCATAGGTAGTCCAGAAGCC,VVIRSNNFTDNAKTIIVQLNESIAINCTRPNNNTRKSIHIGPGRAFYTTGDIIGNIRQAHCNLSRTKWENTLKQIAKKLREQFGNKTIVFNH,negative +CTTCGGCTTCACAGCTTTGGAAAGGGTACAAATTAAACTA,MAMQMQLEANADTSVEEESFGPQPISRLEQCGINANDVKKLEEAGFHTVEAVAYAPKKELINIKGISEAKADKILAEAAKLVPMGFTTATEFHQRRSEIIQITTGSKELDKLLQGGIETGSITEMFGEFRTGKTQICHTLAVTCQLPIDRGGGEGKAMYIDTEGTFRPERLLAVAERYGLSGSDVLDNVAYARAFNTDHQTQLLYQASAMMVESRYALLIVDSATALYRTDYSGRGELSARQMHLARFLRMLLRLADEFGVAVVITNQVVAQVDGAAMFAADPKKPIGGNIIAHASTTRLYLRKGRGETRICKIYDSPCLPEAEAMFAINADGVGDAKD,negative +UUAGCACAAACAACCCCAGAAGUGCAACGC,WPLTEEKIKALVEICXEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEEFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDXIIYQYMDDLYVGSDLEIGQHRTKVEELRQHLLXWGFTTPDKKHQKEPPFLWMGYELHP,negative +CTAAGGATCGGATCCACGGCCTACCAGGTC,IMEIRTVAVGIVAIKGVESEYYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHSGGEMFVALNQKGLPVKGKKTKKEQKTAHFLPMAIT,negative +GAGCGGUUAAGGGAGAUUUAGGCAGCAGCUUGGACAGUGUAUCGGCUGAG,MSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEMLDRHHTHFCPLEGESWQDFLRNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAFLCQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERETPTTDSMPPLLRQAIELFDHQGAEPAFLFGLELIICGLEKQLKCESGS,negative +GUCAGCUGCUCGCGGGAUCGAUCCAUUCGGUGGCCAUGCUCCGGAAGACGGGCCGGCUUCGCAAGACUCAGG,MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA,negative +GAACGACCACCGCTACCGACTACGCCATAAACTGCCCGG,MSSTESPVPAAAAPAEAVPASTPAPAAEQPAVGNGEQRNNADAANNTSLYVGELDPSVTEAMLFEIFSMIGTVASIRVCRDAVTRRSLGYAYVNFLNAADGERAMEQLNYSLIRNRPCRIMWSQRDPALRRTGQGNIFIKNLDAGIDNKALHDTFAAFGNILSCKVATNETGSLGYGFVHYETAEAAEAAIKHVNGMLLNDKKVYVGHHIPRKERQAKIEETRANFTNVYAKNVDPEVTDDEFEKLFTKFGKITSCVLQRDEDGKSKGFGFVNFEDHNEAQKAVDELHDSDFKGQKLFVARAQKKSEREEELRRSYEAAKNEKLAKFQGVNLYLKNIPESYDDERLREEFAPFGAITSCKIMRAPSGVSRGFGFVCYSAPEEANKAVSEMNGKMLDNRPLYVALAQRKDVRRQQLEAQIMQRNQLRLQQQAAAQGMGYPGPGMYYPQPGAFPGQPGGMVPRPRYAPAGMMPQGMPMAPYGQPGQFPAGMMPQGYRPARPPRGAPNAAGGPAPPAGARPPTGVNGAPRPAGQPVPGQPMPRGPAARPAGRPEADQPGALTAAALAKASPEEQKQMLGEAIYPKVAASQPELAGKLTGMILELPVTELLHLLEESEALDAKVNEALEVLKEYQQNDSAGAEAEANAEAPKTEA,negative +UUGUAAGCUCAACGGGUGGAGGGANCGGGCGAACGGGCUGGAGCACUACAAGCUUCUGGACUCGGU,MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINYDEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQAVAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQGIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADMDFSALLSQISS,negative +AAAGAGGAUUUGUGUUUUUCAGGAC,QDRPIKFSTEGATSQSYKQFIEALRERLRGGLIHDIPVLPDPTTLQERNRYITVELSNSDTESIEVGIDVTNAYVVAYRAGTQSYFLRDAPSSASDYLFTGTDQHSLPFYGTYGDLERWAHQSRQQIPLGLQALTHGISFFRSGGNDNEEKARTLIVIIQMVAEAARFRYISNRVRVSIQTGTAFQPDAAMISLENNWDNLSRGVQESVQDTFPNQVTLTNIRNEPVIVDSLSHPTVAVLALMLFVCNPPNANQSPLLIRSIVEKSKICSSRYEPTVRIGGRDGMCVDVYDNGYHNGNRIIMWKCKDRLEENQLWTLKSDKTIRSNGKCLTTYGYAPGSYVMIYDCTSAVAEATYWEIWDNGTIINPKSALVLSAESSSMGGTLTVQTNEYLMRQGWRTGNNTSPFVTSISGYSDLCMQAQGSNVWMADCDSNKKEQQWALYTDGSIRSVQNTNNCLTSKDHKQGSTILLMGCSNGWASQRWVFKNDGSIYSLYDDMVMDVKGSDPSLKQIILWPYTGKPNQIWLTLF,negative +NGACUGAUUUUUCCUUGNCAGUGUAAUUUCCUGGCUGCCC,MAGRSGDSDEELLKAVRLIKFLYQSNPPPNPEGTRQARRNRRRRWRERQRQIHSISERILSTYLGRSAEPVPLQLPPLERLTLDCNEDCGTSGTQGVGSPQILVESPTILESGAKE,negative +CCUGCCCUUUCCAACACCCGCCGAAACUCA,MDKLVVNYYEYKHPIINKDLAIGAHGGKKFPTLGAWYDVINEYEFQTRCPIILKNSHRNKHFTFACHLKNCPFKVLLSYAGNAASSETSSPSANNNTNPPGTPDHIHHHSNNMNNEDNDNNNGSNNKVSNDSKLDFVTDDLEYHLANTHPDDTNDKVESRSNEVNGNNDDDADANNIFKQQGVTIKNDTEDDSINKASIDRGLDDESGPTHGNDSGNHRHNEEDDVHTQMTKNYSDVVNDEDINVAIANAVANVDSQSNNKHDGKDDDATNNNDGQDNNTNNDHNNNSNINNNNVGSHGISSHSPSSIRDTSMNLDVFNSATDDIPGPFVVTKIEPYHSHPLEDNLSLGKFILTKIPKILQNDLKFDQILESSYNNSNHTVSKFKVSHYVEESGLLDILMQRYGLTAEDFEKRLLSQIARRITTYKARFVLKKKKMGEYNDLQPSSSSNNNNNNDGELSGTNLRSNSIDYAKHQEISSAGTSSNTTKNVNNNKNDSNDDNNGNNNNDASNLMESVLDKTSSHRYQPKKMPSVNKWSKPDQITHSDVSMVGLDESNDGGNENVHPTLAEVDAQEARETAQLAIDKINSYKRSIDDKNGDGHNNSSRNVVDENLINDMDSEDAHKSKRQHLSDITLEERNEDDKLPHEVAEQLRLLSSHLKEVENLHQNNDDDVDDVMVDVDVESQYNKNTTHHNNHHSQPHHDEEDVAGLIGKADDEEDLSDENIQPELRGQ,negative +GGGACACAAUGGACGUCCGUAGUUCUGGCUGACUGGUUACCCGGUCGUACAGCUCUAACGGCCGACAUGAGAG,MHGDTPTLHEYMLDLQPETTDLYCYEQLNDSSEEEDEIDGPAGQAEPDRAHYNIVTFCCKCDSTLRLCVQSTHVDIRTLEDLLMGTLGIVCPICSQKP,negative +GUGGUGAAGAGGUACCGGAAUUGCUAAAGAUACCACGGCC,MGVLLTQRTLLSLVLALLFPSMASMAAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQGLDVPKLREHCRERPGAFPSEETLRGLGRRGFLQTLNATLGCVLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILGLRNNIYCMAQLLDNSDTAEPTKAGRGASQPPTPTPASDAFQRKLEGCRFLHGYHRFMHSVGRVFSKWGESPNRSRRHSPHQALRKGVRRTRPSRKGKRLMTRGQLPR,negative +AGGGAATCTTGCCTAGGGAGGGAGTAGCGAAAGGGCTCA,MPEEWVRIFGEAGITQFEQQRNPRLCLSVLNILSKSEHPQEKFMFVPYEQSALPVTDNSPFGDTSITHNYADHHFKASTPENEGSSFYSRVPGPCTVGVRSSSLSSGRGSSEGVGSRSGSGSGGAASRSSSSGHGGAGFPLPVTSVPANGRSSAPGPNSMTVTSGSHSSSGSNCSTGSLTGGMELTNTMVATTQRTGPNNVLVNGHSTGNHFHGGVTQRVAASAAPTECNVLPTYTGSSSSYQPTSFQSMAVHTPPAYTLRQIPPAHSIGYPYTSTAPTSESIILTAPTTTPSSTVYHTTQGSAIVKPLSDNQSQRDKLPYLMHKSQWHSNVTGHVPLSPGLPRRFVDGVLPPETSAHIQYSSGQSSPSPAGSATPVPTPRRESLAGSVPVRAGPAPPALATHELSSDANCTLTPPPVATRPEKTKSIYTKPVEAQCDGHLTIGDQQDASRRSLETPVPPQTAATIHGSENETRTNVTVLPTVHSDGNNSSVHAYQQATESRPLKPNTLERQGQKKVRPKISDEAIQEKLRMIVSIGDPNRKYQRQEKIGQGASGTVYGGIEVATGRRVAIKQMNLKQQPKKELIVNEIYVMKAKKHPNVVNYLDSYLVADELWVVMEYLDGGSLTEVVTETYMEEGQIAAVCRECLQALDFLHKNQVIHRDIKSDNILLGLDGSVKLTDFGFCAQLSSEQNKRSTMVGTPYWMAPEVVTRKQYGPKVDIWSLGIMAIEMLDGEPPYLNENPVRALYLIGTNGKPEIKERDKLSSEFQDFLDLCLEVKVERRATAQELLQHIFSRDGHRAMELLQTDNFHSSGVRKKRTPRLAIEKLVDPEVKRNYQNQLVECLPDGTVSDINGHWEKISKALLKPRRTVVMAAGEDELVVTVRGTSFNCPPTSLVEPNTGIIAPLIEPHHRGIGSYALEVVADIIGTLDYCGIAFLTMGSFVPYLYYSFYCVLWLKLFYLALIFALGSGAIAVSMSNTFASPAYRPLRALVFIALGLSGVIPCVHVTITNGFWPSLQHGSLGWLFLMAVLYITGASIYAVRVPERIFPGRFDIWFQSHQIFHVFVVAAALVHYHGIIGLTNYRLAIGDCRPPPGYPFPKHDYDNIELLRPFMTY,negative +ACCGAAAAAGACCUGACUUCUAUACUAAGUCUACGUUCC,MAGRSGDSDEELLKAVRLIKFLYQSNPPPNPEGTRQARRNRRRRWRERQRQIHSISERILSTYLGRSAEPVPLQLPPLERLTLDCNEDCGTSGTQGVGSPQILVESPTILESGAKE,negative +CACCUACUAGACCACUUUUUGAGCCGGUUUUUUCGGGAACUUGCCAA,MKKTLIALAIAASAASGMAHAWMTGDFNGSVDIGGSITADDYRQKWEWKVGTGLNGFGNVLNDLTNGGTKLTITVTGNKPILLGRTKEAFATPVTGGVDGIPHIAFTDYEGASVVLRNPDGETNKKGLAYFVLPMKNAEGTKVGSVKVNASYAGVLGRGGVTSADGELLSLFADGLSSIFYGGLPRGSELSAGSAAAARTKLFGSLSRNDILGQIQRVNANITSLVDVAGSYRENMEYTDGTVVSAAYALGIANGQTIEATFNQAVTTSTQWSAPLNVAITYY,negative +ACGCGCTAGGATCAAAGCTGCACTGAAGTG,MSAPASTTQATGSTTSTTTKTAGATPATASGLFTIPDGDFFSTARAVVASDAVATNEDLSEIEAVWKDMKVPTDTMAQAAWDLVRHCADVGSSAQTEMIDTGPYSNGISRARLAAAIKEVCTLRQFCMKYAPVVWNWMLTNNSPPANWQAQGFKPEHKFAAFDFFNGVTNPAAIMPKEGLIRPPSEAEMNAAQTAAFVKITKARAQSNDFASLDAAVTRGRITGTTTAEAVVTLPPP,negative +CAGCUAGAGGCAAAGUGGUCUCGACGUAGGGGGACCUGCUCGCUG,DHNPPTIELIQRFCSDVDMWLKEDSSNVVAVHCKAGKGRTGTMICAYLVFSGIKKSADEALAWYDEKRTKDRKGVTIPSQRRYVQYFSKLVCSSVPYSKVSLNVCEIRFSESSCVQNLGMVECSISVLHDSATENAKPDRLKTLPIDFQKSFVLTIKPSIPVSGDVKFELTKKSPDKIICHFWLNTFFVRNYSPCESDGTVNKYIHTLSKSEIDDVHKDSEHKRFSEEFKISIVFEAENFSNDVQAEASEKERNENVLNFERSDYDSLSPNCYAEKKVLTAIVNDNTTKSQTIETLDHKDIVTKIQYDTSTNSKNTSTACKRKQPNSKTLLPSLNDSTKEEIKRNHIFNQPSIKKTDLIKWQNSEVHITRSINENKNINYNSYITCKQSSPKFNCGTEDGEEDWESGESTYL,negative +GCUUGGUACCGAGCUCGGAUCCACGUAGUAACGGGCCGCCAGUGUGCUGGAAUUCGGGUCGUUCUUG,QDRPIKFSTEGATSQSYKQFIEALRERLRGGLIHDIPVLPDPTTLQERNRYITVELSNSDTESIEVGIDVTNAYVVAYRAGTQSYFLRDAPSSASDYLFTGTDQHSLPFYGTYGDLERWAHQSRQQIPLGLQALTHGISFFRSGGNDNEEKARTLIVIIQMVAEAARFRYISNRVRVSIQTGTAFQPDAAMISLENNWDNLSRGVQESVQDTFPNQVTLTNIRNEPVIVDSLSHPTVAVLALMLFVCNPPNANQSPLLIRSIVEKSKICSSRYEPTVRIGGRDGMCVDVYDNGYHNGNRIIMWKCKDRLEENQLWTLKSDKTIRSNGKCLTTYGYAPGSYVMIYDCTSAVAEATYWEIWDNGTIINPKSALVLSAESSSMGGTLTVQTNEYLMRQGWRTGNNTSPFVTSISGYSDLCMQAQGSNVWMADCDSNKKEQQWALYTDGSIRSVQNTNNCLTSKDHKQGSTILLMGCSNGWASQRWVFKNDGSIYSLYDDMVMDVKGSDPSLKQIILWPYTGKPNQIWLTLF,negative +GAAGTGAAAATGACAGAACACAACA,MVKSHIGSWILVLFVAMWSDVGLCKKRPKPGGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGSHSQWNKPSKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGNDYEDRYYRENMYRYPNQVYYRPVDRYSNQNNFVHDCVNITVKQHTVTTTTKGENFTETDIKIMERVVEQMCITQYQRESQAYYQRGASVILFSSPPVILLISFLIFLIVG,negative +AAAGAGGAUUUGUGUUUUUCAGGAC,MEGMLKGEGPGPLPPLLQQYVELRDQYPDYLLLFQVGDFYECFGEDAERLARALGLVLTHKTSKDFTTPMAGIPLRAFEAYAERLLKMGFRLAVADQVEPAEEAEGLVRREVTQLLTPGTLLQESLLPREANYLAAIATGDGWGLAFLDVSTGEFKGTVLKSKSALYDELFRHRPAEVLLAPELLENGAFLDEFRKRFPVMLSEAPFEPEGEGPLALRRARGALLAYAQRTQGGALSLQPFRFYDPGAFMRLPEATLRALEVFEPLRGQDTLFSVLDETRTAPGRRLLQSWLRHPLLDRGPLEARLDRVEGFVREGALREGVRRLLYRLADLERLATRLELGRASPKDLGALRRSLQILPELRALLGEEVGLPDLSPLKEELEAALVEDPPLKVSEGGLIREGYDPDLDALRAAHREGVAYFLELEERERERTGIPTLKVGYNAVFGYYLEVTRPYYERVPKEYRPVQTLKDRQRYTLPEMKEKEREVYRLEALIRRREEEVFLEVRERAKRQAEALREAARILAELDVYAALAEVAVRYGYVRPRFGDRLQIRAGRHPVVERRTEFVPNDLEMAHELVLITGPNMAGKSTFLRQTALIALLAQVGSFVPAEEAHLPLFDGIYTRIGASDDLAGGKSTFMVEMEEVALILKEATENSLVLLDEVGRGTSSLDGVAIATAVAEALHERRAYTLFATHYFELTALGLPRLKNLHVAAREEAGGLVFYHQVLPGPASKSYGVEVAAMAGLPKEVVARARALLQAMAARREGALDAVLERLLALDPDRLTPLEALRLLQELKALALGAPLDTMKG,negative +UUUGGUUAUCAUGUUUAUGCGUACGGGCGCCCAU,MSMSPKHTTPFSVSDILSPLEESYKKVGMEGGGLGAPLAAYRQGQAAPPAAAMQQHAVGHHGAVTAAYHMTAAGVPQLSHSAVGGYCNGNLGNMSELPPYQDTMRNSASGPGWYGANPDPRFPAISRFMGPASGMNMSGMGGLGSLGDVSKNMAPLPSAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGGGGGGGAGCPQQQQAQQQSPRRVAVPVLVKDGKPCQAGAPAPGAGSLQGHAQQQAQQQAQAAQAAAAAISVGSGGPGLGAHPGHQPGSAGQSPDLAHHAASPAALQGQVSSLSHLNSSGSDYGTMSCSTLLYGRTW,negative +GGGAUGAAUAAUAAUAAUA,QDRPIKFSTEGATSQSYKQFIEALRERLRGGLIHDIPVLPDPTTLQERNRYITVELSNSDTESIEVGIDVTNAYVVAYRAGTQSYFLRDAPSSASDYLFTGTDQHSLPFYGTYGDLERWAHQSRQQIPLGLQALTHGISFFRSGGNDNEEKARTLIVIIQMVAEAARFRYISNRVRVSIQTGTAFQPDAAMISLENNWDNLSRGVQESVQDTFPNQVTLTNIRNEPVIVDSLSHPTVAVLALMLFVCNPPNANQSPLLIRSIVEKSKICSSRYEPTVRIGGRDGMCVDVYDNGYHNGNRIIMWKCKDRLEENQLWTLKSDKTIRSNGKCLTTYGYAPGSYVMIYDCTSAVAEATYWEIWDNGTIINPKSALVLSAESSSMGGTLTVQTNEYLMRQGWRTGNNTSPFVTSISGYSDLCMQAQGSNVWMADCDSNKKEQQWALYTDGSIRSVQNTNNCLTSKDHKQGSTILLMGCSNGWASQRWVFKNDGSIYSLYDDMVMDVKGSDPSLKQIILWPYTGKPNQIWLTLF,negative +UCCCCCGCGCACAUUCCCGCCAACCUGCAA,AKVLVVLLLFAGVDAETHVTGGSAAHAASTFAGLFSPGAKQDIQLINTNGSWHINRTA,negative +CAGGCGTTAGGGAAGGGCGTCGAAAGCAGGGTGGG,MASNFTQFVLVDNGGTGDVTVAPSNFANGVAEWISSNSRSQAYKVTCSVRQSSAQNRKYTIKVEVPKVATQTVGGVELPVAAWRSYLNMELTIPIFATNSDCELIVKAMQGLLKDGNPIPSAIAANSGIY,negative +UUGUUACACACCCGAUUGAAAAAGCGAGUCUGACAG,MSSSQKKAGGKAGKPTKRSQNYAALRKAQLPKPPALKVPVVKPTNTILPQTGCVWQSLGTPLSLSSFNGLGARFLYSFLKDFVGPRILEEDLIYRMVFSITPSHAGTFCLTDDVTTEDGRAVAHGNPMQEFPHGAFHANEKFGFELVFTAPTHAGMQNQNFKHSYAVALCLDFDAQPEGSKNPSFRFNEVWVERKAFPRAGPLRSLITVGLFDEADDLDRH,negative +GGACCUUUGUACCCCAGAUGACGGCUCAUUUCGUGCUUGAUGGGUACAAAUGGCAG,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,negative +CGUAUUCAUCAGGUAGCGUAGAUCCGUGUGGCGGGCUGUUCCAUUUUA,VVIRSNNFTDNAKTIIVQLNESIAINCTRPNNNTRKSIHIGPGRAFYTTGDIIGNIRQAHCNLSRTKWENTLKQIAKKLREQFGNKTIVFNH,negative +CCCTTCATCATTAACCCGTCCACGCGC,MKPGGNTIVIWMYAVATWLCFGSTSGWSFTLEDNNIFPKQYPIINFTTAGATVQSYTNFIRAVRGRLTTGADVRHEIPVLPNRVGLPINQRFILVELSNHAELSVTLALDVTNAYVVGYRAGNSAYFFHPDNQEDAEAITHLFTDVQNRYTFAFGGNYDRLEQLAGNLRENIELGNGPLEEAISALYYYSTGGTQLPTLARSFIICIQMISEAARFQYIEGEMRTRIRYNRRSAPDPSVITLENSWGRLSTAIQESNQGAFASPIQLQRRNGSKFSVYDVSILIPIIALMVYRCAPPPSSQFSLLIRPVVPNFNADVCMDPEPIVRIVGRNGLCVDVRDGRFHNGNAIQLWPCKSNTDANQLWTLKRDNTIRSNGKCLTTYGYSPGVYVMIYDCNTAATDATRWQIWDNGTIINPRSSLVLAATSGNSGTTLTVQTNIYAVSQGWLPTNNTQPFVTTIVGLYGLCLQANSGQVWIEDCSSEKAEQQWALYADGSIRPQQNRDNCLTSDSNIRETVVKILSCGPASSGQRWMFKNDGTILNLYSGLVLDVRASDPSLKQIILYPLHGDPNQIWLPLF,negative +GAGCAUUAACAAAAAGAUCACUAGGAACAGCGGUA,MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPGPHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR,negative +TCCCACGCATTCTCCACATCTAGTCTGGTTACGGTCTCGATTGTCCCAAAAGGGCAGACACCTTTCTGTCCTTCCGTCAC,MGLLGILCFLIFLGKTWGQEQTYVISAPKIFRVGASENIVIQVYGYTEAFDATISIKSYPDKKFSYSSGHVHLSSENKFQNSAILTIQPKQLPGGQNPVSYVYLEVVSKHFSKSKRMPITYDNGFLFIHTDKPVYTPDQSVKVRVYSLNDDLKPAKRETVLTFIDPEGSEVDMVEEIDHIGIISFPDFKIPSNPRYGMWTIKAKYKEDFSTTGTAYFEVKEYVLPHFSVSIEPEYNFIGYKNFKNFEITIKARYFYNKVVTEADVYITFGIREDLKDDQKEMMQTAMQNTMLINGIAQVTFDSETAVKELSYYSLEDLNNKYLYIAVTVIESTGGFSEEAEIPGIKYVLSPYKLNLVATPLFLKPGIPYPIKVQVKDSLDQLVGGVPVTLNAQTIDVNQETSDLDPSKSVTRVDDGVASFVLNLPSGVTVLEFNVKTDAPDLPEENQAREGYRAIAYSSLSQSYLYIDWTDNHKALLVGEHLNIIVTPKSPYIDKITHYNYLILSKGKIIHFGTREKFSDASYQSINIPVTQNMVPSSRLLVYYIVTGEQTAELVSDSVWLNIEEKCGNQLQVHLSPDADAYSPGQTVSLNMATGMDSWVALAAVDSAVYGVQRGAKKPLERVFQFLEKSDLGCGAGGGLNNANVFHLAGLTFLTNANADDSQENDEPCKEILRPRRTLQKKIEEIAAKYKHSVVKKCCYDGACVNNDETCEQRAARISLGPRCIKAFTECCVVASQLRANISHKDMQLGRLHMKTLLPVSKPEIRSYFPESWLWEVHLVPRRKQLQFALPDSLTTWEIQGVGISNTGICVADTVKAKVFKDVFLEMNIPYSVVRGEQIQLKGTVYNYRTSGMQFCVKMSAVEGICTSESPVIDHQGTKSSKCVRQKVEGSSSHLVTFTVLPLEIGLHNINFSLETWFGKEILVKTLRVVPEGVKRESYSGVTLDPRGIYGTISRRKEFPYRIPLDLVPKTEIKRILSVKGLLVGEILSAVLSQEGINILTHLPKGSAEAELMSVVPVFYVFHYLETGNHWNIFHSDPLIEKQKLKKKLKEGMLSIMSYRNADYSYSVWKGGSASTWLTAFALRVLGQVNKYVEQNQNSICNSLLWLVENYQLDNGSFKENSQYQPIKLQGTLPVEARENSLYLTAFTVIGIRKAFDICPLVKIDTALIKADNFLLENTLPAQSTFTLAISAYALSLGDKTHPQFRSIVSALKREALVKGNPPIYRFWKDNLQHKDSSVPNTGTARMVETTAYALLTSLNLKDINYVNPVIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVKQLRLSMDIDVSYKHKGALHNYKMTDKNFLGRPVEVLLNDDLIVSTGFGSGLATVHVTTVVHKTSTSEEVCSFYLKIDTQDIEASHYRGYGNSDYKRIVACASYKPSREESSSGSSHAVMDISLPTGISANEEDLKALVEGVDQLFTDYQIKDGHVILQLNSIPSSDFLCVRFRIFELFEVGFLSPATFTVYEYHRPDKQCTMFYSTSNIKIQKVCEGAACKCVEADCGQMQEELDLTISAETRKQTACKPEIAYAYKVSITSITVENVFVKYKATLLDIYKTGEAVAEKDSEITFIKKVTCTNAELVKGRQYLIMGKEALQIKYNFSFRYIYPLDSLTWIEYWPRDTTCSSCQAFLANLDEFAEDIFLNGC,negative +CTTCTGCCCGCCTCCTTCCGGAATGATGCGTAAAGGACCGAGGGTGCTTGCCATAATCGGAGACGAGATAGGCGGACACT,IMEIRTVAVGIVAIKGVESEYYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHSGGEMFVALNQKGLPVKGKKTKKEQKTAHFLPMAIT,negative +GCGGACCCGCCGAAAACGCAACCGUGCACAAUUCUGAGCAUGGGCGGGCCAGUACUACAAGCUUCUGGACUCGGU,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,negative +CAGCTCAGAAGCTTGATCCTGTGAAGGGCTGATGAGGGGCGTAGCGGCTTGTTCGTAAGACTCGAAGTCGTGCATCTGCA,MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQRGLKNVFDEAILAALEPPETQPKRKCCIF,negative +AGAAUGACCCGAUGAGGUACGCCACGACUGCCCACUUCUU,MSPQRDRINAFYKDNPHPKGSRIVINREHLMIDRPYVLLAVLFVMFLSLIGLLAIAGIRLHRAAIYTAEIHKSLSTNLDVTNSIEHQVKDVLTPLFKIIGDEVGLRTPQRFTDLVKFISDKIKFLNPDREYDFRDLTWCINPPERIKLDYDQYCADVAAEELMNALVNSTLLEARATNQFLAVSKGNCSGPTTIRGQFSNMSLSLLDLYLSRGYNVSSIVTMTSQGMYGGTYLVEKPNLSSKGSELSQLSMHRVFEVGVIRNPGLGAPVFHMTNYFEQPVSNDFSNCMVALGELKFAALCHREDSITIPYQGSGKDVSFQLVKLGVWKSPTDMQSWVPLSTDDPVIDRLYLSSHRGVIADNQAKWAVPTTRTDDKLRMETCFQQACKGKIQALCENPDWAPLKDNRIPSYGVLSVNLSLTVELKIKIASGFGPLITHGSGMDLYKSNHNNMYWLTIPPMKNLALGVINTLEWIPRFRVSPNLFTVPIKEAGEDCHAPTYLPAEVDGDVKLSSNLVILPGQDLQYVLATYDTSRVEHAVVYYVYSPSRSFSYFYPFRLPIKGVPIELQVECFTWDQKLWCRHFCVLADSGSGGHITHSGMVGMGVSCTVTREDGTNRR,negative +AGUCUGAGUCAAAUUGUGCCACUCCCACUCCAAUUGCGU,MRKIVVAAIAVSLTTVSITASASADPSKDSKAQVSAAEAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKVKPSAASIDAAKKAGVNNGNPLDAVQQ,negative +TGGGGGTCGGGATACGGTCAGTGGTGGTGAGTGGTAACGG,MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYTFLLPEMDNCRSSSSPYVSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQDNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVLVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF,negative +TCCCACGCATTCTCCACATCGATACTGAGCATCGTACATGATCCCGCAACGGGCAGTATTCCTTTCTGTCCTTCCGTCAC,RRIKRLEQEKLELSRKLQESTQTVQALQYSTVDGPLTASKDLEIKNLKEEIEKLRKQVTESSHLEQQLEEANAVRQELDDAFRQIKAYEKQIKTLQQEREDLNKELVQASERLKNQSKELKDAHCQRKLAMQEFMEINER,negative +GCCAGCATCCCGACTGGGCTCCTCGATAACGAGTGCCCG,MKKTLIALAIAASAASGMAHAWMTGDFNGSVDIGGSITADDYRQKWEWKVGTGLNGFGNVLNDLTNGGTKLTITVTGNKPILLGRTKEAFATPVTGGVDGIPHIAFTDYEGASVVLRNPDGETNKKGLAYFVLPMKNAEGTKVGSVKVNASYAGVLGRGGVTSADGELLSLFADGLSSIFYGGLPRGSELSAGSAAAARTKLFGSLSRNDILGQIQRVNANITSLVDVAGSYRENMEYTDGTVVSAAYALGIANGQTIEATFNQAVTTSTQWSAPLNVAITYY,negative +CCCCCAUGGCACGCCGAUCACGUUUUGCUGUCCGCCGGUCCAUAAAUACU,MSSTESPVPAAAAPAEAVPASTPAPAAEQPAVGNGEQRNNADAANNTSLYVGELDPSVTEAMLFEIFSMIGTVASIRVCRDAVTRRSLGYAYVNFLNAADGERAMEQLNYSLIRNRPCRIMWSQRDPALRRTGQGNIFIKNLDAGIDNKALHDTFAAFGNILSCKVATNETGSLGYGFVHYETAEAAEAAIKHVNGMLLNDKKVYVGHHIPRKERQAKIEETRANFTNVYAKNVDPEVTDDEFEKLFTKFGKITSCVLQRDEDGKSKGFGFVNFEDHNEAQKAVDELHDSDFKGQKLFVARAQKKSEREEELRRSYEAAKNEKLAKFQGVNLYLKNIPESYDDERLREEFAPFGAITSCKIMRAPSGVSRGFGFVCYSAPEEANKAVSEMNGKMLDNRPLYVALAQRKDVRRQQLEAQIMQRNQLRLQQQAAAQGMGYPGPGMYYPQPGAFPGQPGGMVPRPRYAPAGMMPQGMPMAPYGQPGQFPAGMMPQGYRPARPPRGAPNAAGGPAPPAGARPPTGVNGAPRPAGQPVPGQPMPRGPAARPAGRPEADQPGALTAAALAKASPEEQKQMLGEAIYPKVAASQPELAGKLTGMILELPVTELLHLLEESEALDAKVNEALEVLKEYQQNDSAGAEAEANAEAPKTEA,negative +UUCCAUUGGAGUGGAACUGAGUUC,MGCRRTREGPSKAMIFPWKCQSTQRDLWNIFKLWGWTMLCCDFLAHHGTDCWTYHYSEKPMNWQRARRFCRDNYTDLVAIQNKAEIEYLEKTLPFSRSYYWIGIRKIGGIWTWVGTNKSLTEEAENWGDGEPNNKKNKEDCVEIYIKRNKDAGKWNDDACHKLKAALCYTASCQPWSCSGHGECVEIINNYTCNCDVGYYGPQCQFVIQCEPLEAPELGTMDCTHPLGNFSFSSQCAFSCSEGTNLTGIEETTCGPFGNWSSPEPTCQVIQCEPLSAPDLGIMNCSHPLASFSFTSACTFICSEGTELIGKKKTICESSGIWSNPSPICQKLDKSFSMIKEGDYNPLFIPVAVMVTAFSGLAFIIWLARRLKKGM,negative +GUCUAGCUCUAGCCCCUGAUUACUUAAAGUGAUCACACAG,MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINYDEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQAVAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQGIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADMDFSALLSQISS,negative +GGGAGAAGGGAAGTAACAGGAGCAUUAGCUACCAAGGGGUCGGGUUGUGGGUGAGAAGAGGTGACGGTACCAG,MKQYLNTVISNPRPAQALGINQPFVVFCFITSRALSFVPAIYWCFKCLHLAFVADKFKWLPLTSALWTLVSAYLSFVLANGFLLKWLIHYSIGPTIIRLFSLNVINFSFLSLSVSFITHGDNAYLLPAWIAISCFQTAAYIVQDWITSPIIRTLPFRSSSSSSSNYRHNLDFLEITVFAVVPVGIASFFTMVMLIWQLYKYPDSFLVSA,negative +TATTAGTACTAATATTAGTACTAA,RRIKRLEQEKLELSRKLQESTQTVQALQYSTVDGPLTASKDLEIKNLKEEIEKLRKQVTESSHLEQQLEEANAVRQELDDAFRQIKAYEKQIKTLQQEREDLNKELVQASERLKNQSKELKDAHCQRKLAMQEFMEINER,negative +CTACTGAATTTGGCTTTATAAGGGTTACGACCGTCCTCGT,MLPWTALGLALSLRLALARSGAERGPPASAPRGDLMFLLDSSASVSHYEFSRVREFVGQLVAPLPLGTGALRASLVHVGSRPYTEFPFGQHSSGEAAQDAVRASAQRMGDTHTGLALVYAKEQLFAEASGARPGVPKVLVWVTDGGSSDPVGPPMQELKDLGVTVFIVSTGRGNFLELSAAASAPAEKHLHFVDVDDLHIIVQELRGSILDAMRPQQLHATEITSSGFRLAWPPLLTADSGYYVLELVPSAQPGAARRQQLPGNATDWIWAGLDPDTDYDVALVPESNVRLLRPQILRVRTRPGEAGPGASGPESGAGPAPTQLAALPAPEEAGPERIVISHARPRSLRVSWAPALGSAAALGYHVQFGPLRGGEAQRVEVPAGRNCTTLQGLAPGTAYLVTVTAAFRSGRESALSAKACTPDGPRPRPRPVPRAPTPGTASREP,negative +GGGUUAACAAGAUACCGAGAGAGCUGCAGCAUAAGCCUGCAGAGUGGACCAGUACUACAAGCUUCUGGACUCGGU,PGGVQVSLLKEYYEDGYHIVRDIDSTVGVSISDASLPPRTWNGFLAPKTYKNVYIDTYHNQVFDDIFRTFTIDQHVKLACSLPHGRLRGADKPLIVKEWSGAMTDCAMYLNGRGIGSRFDGSFPSGKPSGACGARSKGSSSELSAQQKKDTLRYIEAQLDAFEVGAGWYFWTW,negative +GGTTGGTGTGGTTGG,MGVLLTQRTLLSLVLALLFPSMASMAAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQGLDVPKLREHCRERPGAFPSEETLRGLGRRGFLQTLNATLGCVLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILGLRNNIYCMAQLLDNSDTAEPTKAGRGASQPPTPTPASDAFQRKLEGCRFLHGYHRFMHSVGRVFSKWGESPNRSRRHSPHQALRKGVRRTRPSRKGKRLMTRGQLPR,negative +CUUUCCUAGCGCACAUGCGACCUCUAUGCGUAAUACGAACGUUGACGGU,MNPSAAVIFCLILLGLSGTQGIPLARTVRCNCIHIDDGPVRMRAIGKLEIIPASLSCPRVEIIATMKKNDEQRCLNPESKTIKNLMKAFSQKRSKRAP,negative +GUAUUCUCGGUGGUUUAAUCAGAGUAGAGGAGGCUGACUCCUUUGGUUGGUCUACGUGGAGGUUCCUUUG,MVDREQLVQKARLAEQAERYDDMAAAMKNVTELNEPLSNEERNLLSVAYKNVVGARRSSWRVISSIEQKTSADGNEKKIEMVRAYREKIEKELEAVCQDVLSLLDNYLIKNCSETQYESKVFYLKMKGDYYRYLAEVATGEKRATVVESSEKAYSEAHEISKEHMQPTHPIRLGLALNYSVFYYEIQNAPEQACHLAKTAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDQQDDDGGEGNN,negative +GTGATCGTCCAGCGACCGAGCAGGAAACTTATGTAACGACCCGAAATTCCTGCTTAGACT,PHITDVVLDKANKTPLRQLDPSRLPDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFAKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRQSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPINRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDTASEATRPATLNRFSALQQTLPAENTDNRRVVQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRTRTPATKRSFSKEVEERSRERPSQPEGLRKAASLTEDRGRDPVKREATLPPVSPPKAALSVDEVEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRLGIESTLERSTIAREHMGRLLHQLLCAGHLSTAQYYQGLYETLELAEDMEIDIPHVWLYLAELITPILQEDGVPMGELFREITKPLRPMGKATSLLLEILGLLCKSMGPKKVGMLWREAGLSWREFLAEGQDVGSFVAEKKVEYTLGEESEAPGQRTLAFEELRRQLEKLLKDGGSNQRVFDWIDANLNEQQIASNTLVRALMTTVCYSAIIFETPLRVDVQVLKVRARLLQKYLCDEQKELQALYALQALVVTLEQPANLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFNWLREAEDEESDHN,negative +UGGGGUAUCGCCAAGCGGUAAGGCACCGGAUUCUGAUUCCGGAGGUCGAGGUUCGAAUCCUCGUACCCCAGCCA,MVMGLGVLLLVFVLGLGLTPPTLAQDNSRYTHFLTQHYDAKPQGRDDRYCESIMRRRGLTSPCKDINTFIHGNKRSIKAICENKNGNPHRENLRISKSSFQVTTCKLHGGSPWPPCQYRATAGFRNVVVACENGLPVHLDQSIFRRP,negative +GGTTGGTGTGGTTGG,MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPGPHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR,negative +CAGCGAAAGUUGCGUAUGGGUCACAUCGCAGGCACAUGUCAUCUGGGCG,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,negative +TATTAGTCATAATATTAGTCATAA,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,negative +CCCTTCATCATTAACCCGTCCACGCGC,MEGMLKGEGPGPLPPLLQQYVELRDQYPDYLLLFQVGDFYECFGEDAERLARALGLVLTHKTSKDFTTPMAGIPLRAFEAYAERLLKMGFRLAVADQVEPAEEAEGLVRREVTQLLTPGTLLQESLLPREANYLAAIATGDGWGLAFLDVSTGEFKGTVLKSKSALYDELFRHRPAEVLLAPELLENGAFLDEFRKRFPVMLSEAPFEPEGEGPLALRRARGALLAYAQRTQGGALSLQPFRFYDPGAFMRLPEATLRALEVFEPLRGQDTLFSVLDETRTAPGRRLLQSWLRHPLLDRGPLEARLDRVEGFVREGALREGVRRLLYRLADLERLATRLELGRASPKDLGALRRSLQILPELRALLGEEVGLPDLSPLKEELEAALVEDPPLKVSEGGLIREGYDPDLDALRAAHREGVAYFLELEERERERTGIPTLKVGYNAVFGYYLEVTRPYYERVPKEYRPVQTLKDRQRYTLPEMKEKEREVYRLEALIRRREEEVFLEVRERAKRQAEALREAARILAELDVYAALAEVAVRYGYVRPRFGDRLQIRAGRHPVVERRTEFVPNDLEMAHELVLITGPNMAGKSTFLRQTALIALLAQVGSFVPAEEAHLPLFDGIYTRIGASDDLAGGKSTFMVEMEEVALILKEATENSLVLLDEVGRGTSSLDGVAIATAVAEALHERRAYTLFATHYFELTALGLPRLKNLHVAAREEAGGLVFYHQVLPGPASKSYGVEVAAMAGLPKEVVARARALLQAMAARREGALDAVLERLLALDPDRLTPLEALRLLQELKALALGAPLDTMKG,negative +TATTAATAATAATATTAATAATAA,MAAKVASTSSEEAEGSLVTEGEMGEKALPVVYKRYICSFADCGAAYNKNWKLQAHLCKHTGEKPFPCKEEGCEKGFTSLHHLTRHSLTHTGEKNFTCDSDGCDLRFTTKANMKKHFNRFHNIKICVYVCHFENCGKAFKKHNQLKVHQFSHTQQLPYECPHEGCDKRFSLPSRLKRHEKVHAGYPCKKDDSCSFVGKTWTLYLKHVAECHQDLAVCDVCNRKFRHKDYLRDHQKTHEKERTVYLCPRDGCDRSYTTAFNLRSHIQSFHEEQRPFVCEHAGCGKCFAMKKSLERHSVVHDPEKRKLKEKCPRPKRSLASRLTGYIPPKSKEKNASVSGTEKTDSLVKNKPSGTETNGSLVLDKLTIQ,negative +AAGACGGCCCGGUAUGUAGCCGGAGAUCCGAGACUUGCU,MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP,negative +AUCGGUCUGAACCGGCCCAGCAGACUGCGACGGCACGAU,MSGGDGRGHNTGAHSTSGNINGGPTGLGVGGGASDGSGWSSENNPWGGGSGSGIHWGGGSGHGNGGGNGNSGGGSGTGGNLSAVAAPVAFGFPALSTPGAGGLAVSISAGALSAAIADIMAALKGPFKFGLWGVALYGVLPSQIAKDDPNMMSKIVTSLPADDITESPVSSLPLDKATVNVNVRVVDDVKDERQNISVVSGVPMSVPVVDAKPTERPGVFTASIPGAPVLNISVNNSTPAVQTLSPGVTNNTDKDVRPAGFTQGGNTRDAVIRFPKDSGHNAVYVSVSDVLSPDQVKQRQDEENRRQQEWDATHPVEAAERNYERARAELNQANEDVARNQERQAKAVQVYNSRKSELDAANKTLADAIAEIKQFNRFAHDPMAGGHRMWQMAGLKAQRAQTDVNNKQAAFDAAAKEKSDADAALSSAMESRKKKEDKKRSAENNLNDEKNKPRKGFKDYGHDYHPAPKTENIKGLGDLKPGIPKTPKQNGGGKRKRWTGDKGRKIYEWDSQHGELEGYRASDGQHLGSFDPKTGNQLKGPDPKRNIKKYL,negative +CGTACCAAGATCCCACAACTAGCCGACCAGGATTGCCGGC,MSMSPKHTTPFSVSDILSPLEESYKKVGMEGGGLGAPLAAYRQGQAAPPAAAMQQHAVGHHGAVTAAYHMTAAGVPQLSHSAVGGYCNGNLGNMSELPPYQDTMRNSASGPGWYGANPDPRFPAISRFMGPASGMNMSGMGGLGSLGDVSKNMAPLPSAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGGGGGGGAGCPQQQQAQQQSPRRVAVPVLVKDGKPCQAGAPAPGAGSLQGHAQQQAQQQAQAAQAAAAAISVGSGGPGLGAHPGHQPGSAGQSPDLAHHAASPAALQGQVSSLSHLNSSGSDYGTMSCSTLLYGRTW,negative +TGCAGATGCAAGGTAACCATATCCAAAGCA,VENLMVQELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFSHFRLFDENNDAAILILLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVN,negative +GUAUUCUCGGGUGGUUUAAUCAGGAGUAGAGGAGGGUGAUUCCUUUGGUUGGACUACGUGGAGCUUGUGUUG,MVMGLGVLLLVFVLGLGLTPPTLAQDNSRYTHFLTQHYDAKPQGRDDRYCESIMRRRGLTSPCKDINTFIHGNKRSIKAICENKNGNPHRENLRISKSSFQVTTCKLHGGSPWPPCQYRATAGFRNVVVACENGLPVHLDQSIFRRP,negative +TTCCGGCTATGGTTAAACAAAAGACTAGGGAGGTTATTCA,MRKIVVAAIAVSLTTVSITASASADPSKDSKAQVSAAEAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKVKPSAASIDAAKKAGVNNGNPLDAVQQ,negative +AGCATATAGTATAAAATTATCATATTGGTGTACGTGTACGGGGTACTTTT,MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYTFLLPEMDNCRSSSSPYVSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQDNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVLVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF,negative +CCGCGCAAGGGGUAACCGGAGAAUAUUUGG,MDSTNYISKLFEYAQRQGQISDIKFEEVGTDGPDHLKTFTLRVVIKGHAYPNGVGKTKKEAKRNAAKHALIGMMETTEQKDASVSCPPSPAPSPAPPVRAVISQPKYVSWLNEHSQKNKLSLKALEGARVGPNNTSQCCRYVVGEKEYPEGFGNTKKEAKEEAAMQVYLELCGGSQTTGTVDENCNGTTGKHKEELNGKVVVLSEKVEHMNMSPAQNVPEQYSFITTEETNFIGILNHYCQKTKRFLDFKLVEKSGPSHNPQFVYKVLIDKREYPDGLGKTAKEAKQQAAQLAWSALQEQSDWNSQVSCRSTVSEEGGLSSLTPSSTWESQDATPSSLSIAGSTSESIIFSDSVNVSSPKDESPVNVKPKIRLAANFQMSPVKTKQEGPNLKGNDLGTLSSGRTSNQPVISRFSSEFDSIENIGKGGFGHVYKARRKLEQKYFAVKIVRSKGKAKREVGALADLQHPNIVRYYTAWLEDTAYRCDTASESDTTSDSGSSSSSEFLYIQMELCDKRTLKVWIDERNAHRKPKRREESLSITQQIVNGVEYIHSKKLLHRDLKPANIMFGMSDGEGKGEVKIGDFGLVTAEDNDNDENLLERTKKTGTVSYMAPEQRNQTSYDRKVDIFALGLIYFEPLWDLSGMEKAKVWNDVRSQRFPQQFNSQFTLENKVIESLLCANPEERPDARQLKTKLNECSRVLTRVHNIHQDNRTI,negative +UUGUAAUGUAUACCGCGCGCCC,MPSNQEARLFLAVLVLAQVLPILVDSAAEKGFKQAFWQPLCQVSEELDDQPKGALFTLQAAASKIQKMRDAALRASIYAEINHGTNRAKAAVIVANHYAMKADSGLEALKQTLSSQEVTATATASYLKGRIDEYLNLLLQTKESGTSGCMMDTSGTNTVTKAGGTIGGVPCKLQLSPIQPKRPAATYLGKAGYVGLTRQADAANNFHDNDAECRLASGHNTNGLGKSGQLSAAVTMAAGYVTVANSQTAVTVQALDALQEASGAAHQPWIDAWKAKKALTGAETAEFRNETAGIAGKTGVTKLVEEALLKKKDSEASEIQTELKKYFSGHENEQWTAIEKLISEQPVAQNLVGDNQPTKLGELEGNAKLTTILAYYRMETAGKFEVLTQKHKPAESQQQAAETEGSCNKKDQNECKSPCKWHNDAENKKCTLDKEEAKKVADETAKDGKTGNTNTTGSSNSFVISKTPLWLAVLLF,negative +GGGAGAAUUCAACUGCCAUCUAGGCAGUAGGAAUACCCCCAUCCAAAGCUCGCUAGGCUGAACACAGUACUACAAGCUUCUGGACUCGGU,PHITDVVLDKANKTPLRQLDPSRLPDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFAKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRQSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPINRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDTASEATRPATLNRFSALQQTLPAENTDNRRVVQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRTRTPATKRSFSKEVEERSRERPSQPEGLRKAASLTEDRGRDPVKREATLPPVSPPKAALSVDEVEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRLGIESTLERSTIAREHMGRLLHQLLCAGHLSTAQYYQGLYETLELAEDMEIDIPHVWLYLAELITPILQEDGVPMGELFREITKPLRPMGKATSLLLEILGLLCKSMGPKKVGMLWREAGLSWREFLAEGQDVGSFVAEKKVEYTLGEESEAPGQRTLAFEELRRQLEKLLKDGGSNQRVFDWIDANLNEQQIASNTLVRALMTTVCYSAIIFETPLRVDVQVLKVRARLLQKYLCDEQKELQALYALQALVVTLEQPANLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFNWLREAEDEESDHN,negative +TGCAGTGCCGAAATAAAGTGTAAAAGCAGTATAAGAAGAC,MDSTNYISKLFEYAQRQGQISDIKFEEVGTDGPDHLKTFTLRVVIKGHAYPNGVGKTKKEAKRNAAKHALIGMMETTEQKDASVSCPPSPAPSPAPPVRAVISQPKYVSWLNEHSQKNKLSLKALEGARVGPNNTSQCCRYVVGEKEYPEGFGNTKKEAKEEAAMQVYLELCGGSQTTGTVDENCNGTTGKHKEELNGKVVVLSEKVEHMNMSPAQNVPEQYSFITTEETNFIGILNHYCQKTKRFLDFKLVEKSGPSHNPQFVYKVLIDKREYPDGLGKTAKEAKQQAAQLAWSALQEQSDWNSQVSCRSTVSEEGGLSSLTPSSTWESQDATPSSLSIAGSTSESIIFSDSVNVSSPKDESPVNVKPKIRLAANFQMSPVKTKQEGPNLKGNDLGTLSSGRTSNQPVISRFSSEFDSIENIGKGGFGHVYKARRKLEQKYFAVKIVRSKGKAKREVGALADLQHPNIVRYYTAWLEDTAYRCDTASESDTTSDSGSSSSSEFLYIQMELCDKRTLKVWIDERNAHRKPKRREESLSITQQIVNGVEYIHSKKLLHRDLKPANIMFGMSDGEGKGEVKIGDFGLVTAEDNDNDENLLERTKKTGTVSYMAPEQRNQTSYDRKVDIFALGLIYFEPLWDLSGMEKAKVWNDVRSQRFPQQFNSQFTLENKVIESLLCANPEERPDARQLKTKLNECSRVLTRVHNIHQDNRTI,negative +CACGGUACCACCAAGUCACACGUUGAACUCCAUGCAGCUG,QDRPIKFSTEGATSQSYKQFIEALRERLRGGLIHDIPVLPDPTTLQERNRYITVELSNSDTESIEVGIDVTNAYVVAYRAGTQSYFLRDAPSSASDYLFTGTDQHSLPFYGTYGDLERWAHQSRQQIPLGLQALTHGISFFRSGGNDNEEKARTLIVIIQMVAEAARFRYISNRVRVSIQTGTAFQPDAAMISLENNWDNLSRGVQESVQDTFPNQVTLTNIRNEPVIVDSLSHPTVAVLALMLFVCNPPNANQSPLLIRSIVEKSKICSSRYEPTVRIGGRDGMCVDVYDNGYHNGNRIIMWKCKDRLEENQLWTLKSDKTIRSNGKCLTTYGYAPGSYVMIYDCTSAVAEATYWEIWDNGTIINPKSALVLSAESSSMGGTLTVQTNEYLMRQGWRTGNNTSPFVTSISGYSDLCMQAQGSNVWMADCDSNKKEQQWALYTDGSIRSVQNTNNCLTSKDHKQGSTILLMGCSNGWASQRWVFKNDGSIYSLYDDMVMDVKGSDPSLKQIILWPYTGKPNQIWLTLF,negative +TCGAATAGCCCCCCGCGTCCGTCTTCCTTTAGCGATCTATGCTCCTTTGTATGGTCGGGC,SHGGLPCQNSQRGKRSFPAVEICKYKGPARIVVSLVTNEDTPRPHAHSLVGKHCKDGLCTVQVGPNDMTASFPNLGILHVTRKDVVPTLKTRILAQHRLYKDLINNSGGEGQWMEPSDQEIEKKAKEMAKDMDLSVVRLCFQTYLPDVKGHFTQPLEPVISVPVFDSKAPNATTLKICRMDKSAGCCTGGEEVYLLCDKVQKEVIQVKFFEVST,negative +CTTCTGCCCGCCTCCTTCCCGCACTTGCAAACCTTCATGGTCTCGTGCTTGAGTGGTTGGAGACGAGATAGGCGGACACT,MSMSPKHTTPFSVSDILSPLEESYKKVGMEGGGLGAPLAAYRQGQAAPPAAAMQQHAVGHHGAVTAAYHMTAAGVPQLSHSAVGGYCNGNLGNMSELPPYQDTMRNSASGPGWYGANPDPRFPAISRFMGPASGMNMSGMGGLGSLGDVSKNMAPLPSAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGGGGGGGAGCPQQQQAQQQSPRRVAVPVLVKDGKPCQAGAPAPGAGSLQGHAQQQAQQQAQAAQAAAAAISVGSGGPGLGAHPGHQPGSAGQSPDLAHHAASPAALQGQVSSLSHLNSSGSDYGTMSCSTLLYGRTW,negative +GAAUCAUACACAAGUUGUGGAG,MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPGPHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR,negative +CCUCUUGCACCGCCGAGAAUAUAAUUCAAGAGGUCCACAACUAAUUAG,MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA,negative +GGATGATGCCGCACTGACGCCACGTAGGTGGCGCACAGCC,MSKRKAPQETLNGGITDMLVELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVTGIGPSAARKLVDEGIKTLEDLRKNEDKLNHHQRIGLKYFEDFEKRIPREEMLQMQDIVLNEVKKLDPEYIATVCGSFRRGAESSGDMDVLLTHPNFTSESSKQPKLLHRVVEQLQKVRFITDTLSKGETKFMGVCQLPSENDENEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEQDIFDYIQWRYREPKDRSE,negative +CCCCGGAACCTTTCCCTAGCCGAAACAGCCC,MKPGGNTIVIWMYAVATWLCFGSTSGWSFTLEDNNIFPKQYPIINFTTAGATVQSYTNFIRAVRGRLTTGADVRHEIPVLPNRVGLPINQRFILVELSNHAELSVTLALDVTNAYVVGYRAGNSAYFFHPDNQEDAEAITHLFTDVQNRYTFAFGGNYDRLEQLAGNLRENIELGNGPLEEAISALYYYSTGGTQLPTLARSFIICIQMISEAARFQYIEGEMRTRIRYNRRSAPDPSVITLENSWGRLSTAIQESNQGAFASPIQLQRRNGSKFSVYDVSILIPIIALMVYRCAPPPSSQFSLLIRPVVPNFNADVCMDPEPIVRIVGRNGLCVDVRDGRFHNGNAIQLWPCKSNTDANQLWTLKRDNTIRSNGKCLTTYGYSPGVYVMIYDCNTAATDATRWQIWDNGTIINPRSSLVLAATSGNSGTTLTVQTNIYAVSQGWLPTNNTQPFVTTIVGLYGLCLQANSGQVWIEDCSSEKAEQQWALYADGSIRPQQNRDNCLTSDSNIRETVVKILSCGPASSGQRWMFKNDGTILNLYSGLVLDVRASDPSLKQIILYPLHGDPNQIWLPLF,negative +CAGCTCAGAAGCTTGATCCTGTGAAGGGCTGATGAGGGGCGTAGCGGCTTGTTCGTAAGACTCGAAGTCGTGCATCTGCA,MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINYDEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQAVAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQGIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADMDFSALLSQISS,negative +GCUAGGCAAUGAAACGGUUGGAGUAAUCCGGUGGCUUGCCAUGAUUUACGUGAGUGCUGAUCCGUGAUG,MVMGLGVLLLVFVLGLGLTPPTLAQDNSRYTHFLTQHYDAKPQGRDDRYCESIMRRRGLTSPCKDINTFIHGNKRSIKAICENKNGNPHRENLRISKSSFQVTTCKLHGGSPWPPCQYRATAGFRNVVVACENGLPVHLDQSIFRRP,negative +GCAACAGAGGCUGAUGGUAGACGCCGGCCA,MRQTLPCIYFWGGLLPFGMLCASSTTKCTVSHEVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQALKSEELDIFANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFNPFDCTCESIAWFVNWINETHTNIPELSSHYLCNTPPHYHGFPVRLFDTSSCKDSAPFELFFMINTSILLIFIFIVLLIHFEGWRISFYWNVSVHRVLGFKEIDRQTEQFEYAAYIIHAYKDKDWVWEHFSSMEKEDQSLKFCLEERDFEAGVFELEAIVNSIKRSRKIIFVITHHLLKDPLCKRFKVHHAVQQAIEQNLDSIILVFLEEIPDYKLNHALCLRRGMFKSHCILNWPVQKERIGAFRHKLQVALGSKNSVH,negative +CGAUACAGCACUGAUUGCGGUCGAGGUAGCUUGAUGGGCC,MLNQLDNLTERVRGSNKLVDRWLHVRKHLLVAYYNLVGIKPGKESYMRLNEKALDDFCQSLVDYLSAGHFSIYERILHKLEGNGQLARAAKIWPQLEANTQQIMDYYDSSLETAIDHDNYLEFQQVLSDIGEALEARFVLEDKLILLVLDAARVKHPA,negative +GGGGCCACCAACGACAUUUAUCGAAUUGAUAACCUUACGCGAGAGCGUAGUUCGUUGAUAUAAAUAGUGCCCAUGGAUC,VVIRSNNFTDNAKTIIVQLNESIAINCTRPNNNTRKSIHIGPGRAFYTTGDIIGNIRQAHCNLSRTKWENTLKQIAKKLREQFGNKTIVFNH,negative +CGGGGTGTTGTCCTGTGCTCTCCGGAGAGCACAGGACAACACCCCG,MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTSQVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHPTNVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEALGYRQDDPSYRSFHSAGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL,negative +TCCCTACGGCGCTAACGACGGGGGAGTTGTGCTCCCGAAAGGAGGTGCCACCGTGCTACAAC,MIPPPRRSASSTPKDYRSSRDLQPWRGVSSGDAAETSQQSRHRRDAIADGGGRLKGAAQSSPSSGTRRSGPYAQGRAMPKNENIPKPGKQRLGPRKKKLSTLKKKILLDRLERWRDKQHEGALSTPSATASSEEAKCNNPFPLCPPGELSPPPSPPATICPAVVDKSTSYGQVGGANGERSVWAITIYNLVDQEDVEDDDDHAEIERDLWDMSSAFGVVRSVQVPRGTAVQVSDAEVSAAAAAGEPAAVAAKVAFATNAEAECARDGLNGRIVGGKPLLVRIHRCDGHFCGGVCPGDPDGSGLWRVAIENLIDEEDDLDDEDEYAEISANVSAMMGCYGKLVDVQVRRSSPSKGEVQEDVATRAATTAGATQAVVVTFGSLAEAEACVQGIKGCRVGGKELDAHVVLDSERVLPSNPAFKCDQEHAHSSDVAAAVAGQGDSMMKQEAGTEPSPCVDQDTAAAVASSTEWRVVIRGLIDEDDLQDDDDDYAEVCSDVTALVSSYGAVVGLDIPRGRETGSCCYGAEPGEAVVVFRSLQEAEACARGLSGRKVAGNILDAQVLTQPAPSQQGPLQGGASGTGPPVANRERKPAKECPLPQHQASSHQSCGKVPELDGSGPGMLRGFGNRVEDCCGRPKIACTDSDEPQAIAAAAPPGQSIEGPKTTALAKAGKRIQTKYQEAAALPKPPGVRGGLPNAYVNQPPDKEVNDLVFEMLQLLFKFQERARLSDPSKAKTRRRLVIGLREVLRGVKAKKVRLLIVAPNVDAVGGEGGLDDKVVEIIDKAREAEYPVVFALSKRKIGKALGKTIKVSAVGVYSFDGANEQQKQLKRRMETISSLPSPSPRQSDPPTDDALASPPSSSACGDSQDPAGKGSRV,negative +CCACCACCACAACAAAACTCCAC,MSMSPKHTTPFSVSDILSPLEESYKKVGMEGGGLGAPLAAYRQGQAAPPAAAMQQHAVGHHGAVTAAYHMTAAGVPQLSHSAVGGYCNGNLGNMSELPPYQDTMRNSASGPGWYGANPDPRFPAISRFMGPASGMNMSGMGGLGSLGDVSKNMAPLPSAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGGGGGGGAGCPQQQQAQQQSPRRVAVPVLVKDGKPCQAGAPAPGAGSLQGHAQQQAQQQAQAAQAAAAAISVGSGGPGLGAHPGHQPGSAGQSPDLAHHAASPAALQGQVSSLSHLNSSGSDYGTMSCSTLLYGRTW,negative +GCCACGAUCACGGGC,MDKFWWHAAWGLCLVPLSLAQIDLNITCRFAGVFHVEKNGRYSISRTEAADLCKAFNSTLPTMAQMEKALSIGFETCRYGFIEGHVVIPRIHPNSICAANNTGVYILTSNTSQYDTYCFNASAPPEEDCTSVTDLPNAFDGPITITIVNRDGTRYVQKGEYRTNPEDIYPSNPTDDDVSSGSSSERSSTSGGYIFYTFSTVHPIPDEDSPWITDSTDRIPATTLMSTSATATETATKRQETWDWFSWLFLPSESKNHLHTTTQMAGTSSNTISAGWEPNEENEDERDRHLSFSGSGIDDDEDFISSTISTTPRAFDHTKQNQDWTQWNPSHSNPEVLLQTTTRMTDVDRNGTTAYEGNWNPEAHPPLIHHEHHEEEETPHSTSTIQATPSSTTEETATQKEQWFGNRWHEGYRQTPKEDSHSTTGTAAASAHTSHPMQGRTTPSPEDSSWTDFFNPISHPMGRGHQAGRRMDMDSSHSITLQPTANPNTGLVEDLDRTGPLSMTTQQSNSQSFSTSHEGLEEDKDHPTTSTLTSSNRNDVTGGRRDPNHSEGSTTLLEGYTSHYPHTKESRTFIPVTSAKTGSFGVTAVTVGDSNSNVNRSLSGDQDTFHPSGGSHTTHGSESDGHSHGSQEGGANTTSGPIRTPQIPEWLIILASLLALALILAVCIAVNSRRRCGQKKKLVINSGNGAVEDRKPSGLNGEASKSQEMVHLVNKESSETPDQFMTADETRNLQNVDMKIGV,negative +GUUUAUAUAUACACAGGUUAAGCGUAACUUCGCUGGACAGCAAGAAUCCU,MKKRKVLIPLMALSTILVSSTGNLEVIQAEVKQENRLLNESESSSQGLLGYYFSDLNFQAPMVVTSSTTGDLSIPSSELENIPSENQYFQSAIWSGFIKVKKSDEYTFATSADNHVTMWVDDQEVINKASNSNKIRLEKGRLYQIKIQYQRENPTEKGLDFKLYWTDSQNKKEVISSDNLQLPELKQKSSNSRKKRSTSAGPTVPDRDNDGIPDSLEVEGYTVDVKNKRTFLSPWISNIHEKKGLTKYKSSPEKWSTASDPYSDFEKVTGRIDKNVSPEARHPLVAAYPIVHVDMENIILSKNEDQSTQNTDSQTRTISKNTSTSRTHTSEVHGNAEVHASFFDIGGSVSAGFSNSNSSTVAIDHSLSLAGERTWAETMGLNTADTARLNANIRYVNTGTAPIYNVLPTTSLVLGKNQTLATIKAKENQLSQILAPNNYYPSKNLAPIALNAQDDFSSTPITMNYNQFLELEKTKQLRLDTDQVYGNIATYNFENGRVRVDTGSNWSEVLPQIQETTARIIFNGKDLNLVERRIAAVNPSDPLETTKPDMTLKEALKIAFGFNEPNGNLQYQGKDITEFDFNFDQQTSQNIKNQLAELNATNIYTVLDKIKLNAKMNILIRDKRFHYDRNNIAVGADESVVKEAHREVINSSTEGLLLNIDKDIRKILSGYIVEIEDTEGLKEVINDRYDMLNISSLRQDGKTFIDFKKYNDKLPLYISNPNYKVNVYAVTKENTIINPSENGDTSTNGIKKILIFSKKGYEIG,negative +ATTGACCGCTGTGTGACGCAACACTCAAT,PHITDVVLDKANKTPLRQLDPSRLPDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFAKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRQSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPINRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDTASEATRPATLNRFSALQQTLPAENTDNRRVVQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRTRTPATKRSFSKEVEERSRERPSQPEGLRKAASLTEDRGRDPVKREATLPPVSPPKAALSVDEVEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRLGIESTLERSTIAREHMGRLLHQLLCAGHLSTAQYYQGLYETLELAEDMEIDIPHVWLYLAELITPILQEDGVPMGELFREITKPLRPMGKATSLLLEILGLLCKSMGPKKVGMLWREAGLSWREFLAEGQDVGSFVAEKKVEYTLGEESEAPGQRTLAFEELRRQLEKLLKDGGSNQRVFDWIDANLNEQQIASNTLVRALMTTVCYSAIIFETPLRVDVQVLKVRARLLQKYLCDEQKELQALYALQALVVTLEQPANLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFNWLREAEDEESDHN,negative +UGUUGUUGGACCAGUGUUAUUUUACGCGAUUGUGCGGUUGUGA,MKRASAGGSRLLAWVLWLQAWQVAAPCPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDNPWVCDCRARPLWAWLQKFRGSSSEVPCSLPQRLAGRDLKRLAANDLQGCAVATGPYHPIWTGRATDEEPLGLPKCCQPDAADKASVLEPGRPASAGNALKGRVPPGDSPPGNGSGPRHINDSPFGTLPGSAEPPLTAVRPEGSEPPGFPTSGPRRRPGCSRKNRTRSHCRLGQAGSGGGGTGDSEGSGALPSLTCSLTPLGLALVLWTVLGPC,negative +GAAGCUUACAAGAAGGACAGCACGAAUAAAACCUGCGUAAAUCCGCCCCAUUUGUGUAAGGGUAGUGGGUCGAAUUCCGCUCA,MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM,negative +AAGACTAGAAGAAGTATTAAGCCTGTATTACAGAAGAGGT,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +GGGAUAUCCUCGAGCAUAAGAAACAAGAUAGAUCCUGAAACUGUUUUAAGGUUGGCCGAUCUUCUGCUCGAGAAUGCAUGAAGCGUUCCAUAUUUUU,MLPWTALGLALSLRLALARSGAERGPPASAPRGDLMFLLDSSASVSHYEFSRVREFVGQLVAPLPLGTGALRASLVHVGSRPYTEFPFGQHSSGEAAQDAVRASAQRMGDTHTGLALVYAKEQLFAEASGARPGVPKVLVWVTDGGSSDPVGPPMQELKDLGVTVFIVSTGRGNFLELSAAASAPAEKHLHFVDVDDLHIIVQELRGSILDAMRPQQLHATEITSSGFRLAWPPLLTADSGYYVLELVPSAQPGAARRQQLPGNATDWIWAGLDPDTDYDVALVPESNVRLLRPQILRVRTRPGEAGPGASGPESGAGPAPTQLAALPAPEEAGPERIVISHARPRSLRVSWAPALGSAAALGYHVQFGPLRGGEAQRVEVPAGRNCTTLQGLAPGTAYLVTVTAAFRSGRESALSAKACTPDGPRPRPRPVPRAPTPGTASREP,negative +CTCCTCTGACTGTAACCACGCAGCCACCAGGAAGATGAATGCTCGAGCAACTCGACGGTCGGCATAGGTAGTCCAGAAGCC,QELLCAASLISDRWVLTAAHCLLYPPWDKNFTVNDILVRIGKYARSRYERNMEKISTLEKIIIHPGYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDKQIVTSLLQAGHKGRVTGWGNLKEMWTVNMNEVQPSVLQMVNLPLVERPICKASTGIRVTDNMFCAGYKPEEGKRGDACEGDSGGPFVMKNPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIRKMVDRFG,negative +GGACCGAGAAGUUACCCUGUAAUCUUAGGAUGAAUCGCAUGCUCUAGCGACCUUUUCGGCUUCGGCGUACGCACAUCGCAGCAAC,MKKRKVLIPLMALSTILVSSTGNLEVIQAEVKQENRLLNESESSSQGLLGYYFSDLNFQAPMVVTSSTTGDLSIPSSELENIPSENQYFQSAIWSGFIKVKKSDEYTFATSADNHVTMWVDDQEVINKASNSNKIRLEKGRLYQIKIQYQRENPTEKGLDFKLYWTDSQNKKEVISSDNLQLPELKQKSSNSRKKRSTSAGPTVPDRDNDGIPDSLEVEGYTVDVKNKRTFLSPWISNIHEKKGLTKYKSSPEKWSTASDPYSDFEKVTGRIDKNVSPEARHPLVAAYPIVHVDMENIILSKNEDQSTQNTDSQTRTISKNTSTSRTHTSEVHGNAEVHASFFDIGGSVSAGFSNSNSSTVAIDHSLSLAGERTWAETMGLNTADTARLNANIRYVNTGTAPIYNVLPTTSLVLGKNQTLATIKAKENQLSQILAPNNYYPSKNLAPIALNAQDDFSSTPITMNYNQFLELEKTKQLRLDTDQVYGNIATYNFENGRVRVDTGSNWSEVLPQIQETTARIIFNGKDLNLVERRIAAVNPSDPLETTKPDMTLKEALKIAFGFNEPNGNLQYQGKDITEFDFNFDQQTSQNIKNQLAELNATNIYTVLDKIKLNAKMNILIRDKRFHYDRNNIAVGADESVVKEAHREVINSSTEGLLLNIDKDIRKILSGYIVEIEDTEGLKEVINDRYDMLNISSLRQDGKTFIDFKKYNDKLPLYISNPNYKVNVYAVTKENTIINPSENGDTSTNGIKKILIFSKKGYEIG,negative +GGGGCCACCAACGACAUUGAACCACGUAGGCUCGUUUCUGAGCCGAUCUCGAUGUUGAUAUAAAUAGUGCCCAUGGAUC,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,negative +UCGUGCCUUUUCUCGAUGGAGUGAGAAGAGGUGACGG,MKPGGNTIVIWMYAVATWLCFGSTSGWSFTLEDNNIFPKQYPIINFTTAGATVQSYTNFIRAVRGRLTTGADVRHEIPVLPNRVGLPINQRFILVELSNHAELSVTLALDVTNAYVVGYRAGNSAYFFHPDNQEDAEAITHLFTDVQNRYTFAFGGNYDRLEQLAGNLRENIELGNGPLEEAISALYYYSTGGTQLPTLARSFIICIQMISEAARFQYIEGEMRTRIRYNRRSAPDPSVITLENSWGRLSTAIQESNQGAFASPIQLQRRNGSKFSVYDVSILIPIIALMVYRCAPPPSSQFSLLIRPVVPNFNADVCMDPEPIVRIVGRNGLCVDVRDGRFHNGNAIQLWPCKSNTDANQLWTLKRDNTIRSNGKCLTTYGYSPGVYVMIYDCNTAATDATRWQIWDNGTIINPRSSLVLAATSGNSGTTLTVQTNIYAVSQGWLPTNNTQPFVTTIVGLYGLCLQANSGQVWIEDCSSEKAEQQWALYADGSIRPQQNRDNCLTSDSNIRETVVKILSCGPASSGQRWMFKNDGTILNLYSGLVLDVRASDPSLKQIILYPLHGDPNQIWLPLF,negative +ATCGATGACCCGTAGTGCAGTGAATTACGT,MSSSQKKAGGKAGKPTKRSQNYAALRKAQLPKPPALKVPVVKPTNTILPQTGCVWQSLGTPLSLSSFNGLGARFLYSFLKDFVGPRILEEDLIYRMVFSITPSHAGTFCLTDDVTTEDGRAVAHGNPMQEFPHGAFHANEKFGFELVFTAPTHAGMQNQNFKHSYAVALCLDFDAQPEGSKNPSFRFNEVWVERKAFPRAGPLRSLITVGLFDEADDLDRH,negative +ATCGATGACCCGTAGTGCAGTGAATTACGT,MSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEMLDRHHTHFCPLEGESWQDFLRNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAFLCQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERETPTTDSMPPLLRQAIELFDHQGAEPAFLFGLELIICGLEKQLKCESGS,negative +TCTGCTACGCTGAGTGGCTGTTTACCTTCGT,MKPGGNTIVIWMYAVATWLCFGSTSGWSFTLEDNNIFPKQYPIINFTTAGATVQSYTNFIRAVRGRLTTGADVRHEIPVLPNRVGLPINQRFILVELSNHAELSVTLALDVTNAYVVGYRAGNSAYFFHPDNQEDAEAITHLFTDVQNRYTFAFGGNYDRLEQLAGNLRENIELGNGPLEEAISALYYYSTGGTQLPTLARSFIICIQMISEAARFQYIEGEMRTRIRYNRRSAPDPSVITLENSWGRLSTAIQESNQGAFASPIQLQRRNGSKFSVYDVSILIPIIALMVYRCAPPPSSQFSLLIRPVVPNFNADVCMDPEPIVRIVGRNGLCVDVRDGRFHNGNAIQLWPCKSNTDANQLWTLKRDNTIRSNGKCLTTYGYSPGVYVMIYDCNTAATDATRWQIWDNGTIINPRSSLVLAATSGNSGTTLTVQTNIYAVSQGWLPTNNTQPFVTTIVGLYGLCLQANSGQVWIEDCSSEKAEQQWALYADGSIRPQQNRDNCLTSDSNIRETVVKILSCGPASSGQRWMFKNDGTILNLYSGLVLDVRASDPSLKQIILYPLHGDPNQIWLPLF,negative +UAUAUAUGUGUGUCUAUCGUCACUUGUAUGUCAAAUAUU,PHITDVVLDKANKTPLRQLDPSRLPDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFAKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRQSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPINRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDTASEATRPATLNRFSALQQTLPAENTDNRRVVQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRTRTPATKRSFSKEVEERSRERPSQPEGLRKAASLTEDRGRDPVKREATLPPVSPPKAALSVDEVEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRLGIESTLERSTIAREHMGRLLHQLLCAGHLSTAQYYQGLYETLELAEDMEIDIPHVWLYLAELITPILQEDGVPMGELFREITKPLRPMGKATSLLLEILGLLCKSMGPKKVGMLWREAGLSWREFLAEGQDVGSFVAEKKVEYTLGEESEAPGQRTLAFEELRRQLEKLLKDGGSNQRVFDWIDANLNEQQIASNTLVRALMTTVCYSAIIFETPLRVDVQVLKVRARLLQKYLCDEQKELQALYALQALVVTLEQPANLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFNWLREAEDEESDHN,negative +CUUGCCGUAGACCCAUUUUCCAAUCACAAGUCACGCGUCUCAAGCUGUUA,AKVLVVLLLFAGVDAETHVTGGSAAHAASTFAGLFSPGAKQDIQLINTNGSWHINRTA,negative +ATGGCTGTGGTGGAGGGCCGAAGCCTGTACAAAACAGGAATGCGCTTATCTTGGAGTAT,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,negative +CGGACGAAATTCGTCCCTGTGTG,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +CGGGGTGTTGTCCTGTGCTCTCCGGAGAGCACAGGACAACACCCCG,MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPGPHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR,negative +GUCGAGACAUAAGAAACAAGAAGAUCCUGAAACUGUUUUAAGGUUGGCCGAUCUUCUGCUCGAGAAUGCAUGAAAGCGUU,MTRCTADNSLTNPAYRRRTMATGEMKEFLGIKGTEPTDFGINSDAQDLPSPSRQASTRRMSIGESIDGKINDWEEPRLDIEGFVVDYFTHRIRQNGMEWFGAPGLPCGVQPEHEMMRVMGTIFEKKHAENFETFCEQLLAVPRISFSLYQDVVRTVGNAQTDQCPMSYGRLIGLISFGGFVAAKMMESVELQGQVRNLFVYTSLFIKTRIRNNWKEHNRSWDDFMTLGKQMKEDYERAEAEKVGRRKQNRRWSMIGAGVTAGAIGIVGVVVCGRMMFSLK,negative +CCCTTCATCATTAACCCGTCCACGCGC,MSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA,negative +CCTTCGTTGTCTGCCTTCGTTAATCGGCTCGATTGATTCGAGGTGACGGTCGTTGGACGTGACGTTACGCACCCTTCAGAATTCGCACCA,MGVLLTQRTLLSLVLALLFPSMASMAAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQGLDVPKLREHCRERPGAFPSEETLRGLGRRGFLQTLNATLGCVLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILGLRNNIYCMAQLLDNSDTAEPTKAGRGASQPPTPTPASDAFQRKLEGCRFLHGYHRFMHSVGRVFSKWGESPNRSRRHSPHQALRKGVRRTRPSRKGKRLMTRGQLPR,negative +GGCUUAGCUAAACGUAGCGGGUAUCGAACGCGAGCGGCAUGCCGAUAUCAUGAGUAGCCGUGAUAGCAUGCUGCUCGGAUAAGCA,MLDLFADAEPWQEPLAAGAVILRRFAFNAAEQLIRDINDVASQSPFRQMVTPGGYTMSVAMTNCGHLGWTTHRQGYLYSPIDPQTNKPWPAMPQSFHNLCQRAATAAGYPDFQPDACLINRYAPGAKLSLHQDKDEPDLRAPIVSVSLGLPAIFQFGGLKRNDPLKRLLLEHGDVVVWGGESRLFYHGIQPLKAGFHPLTIDCRYNLTFRQAGKKE,negative +TTACCGTGATGTATGATATGCATCCACCGTG,MKQYLNTVISNPRPAQALGINQPFVVFCFITSRALSFVPAIYWCFKCLHLAFVADKFKWLPLTSALWTLVSAYLSFVLANGFLLKWLIHYSIGPTIIRLFSLNVINFSFLSLSVSFITHGDNAYLLPAWIAISCFQTAAYIVQDWITSPIIRTLPFRSSSSSSSNYRHNLDFLEITVFAVVPVGIASFFTMVMLIWQLYKYPDSFLVSA,negative +GUAUUCUCGGUGGUUUAAUCAGAGUAGAGGAGGCUGACUCCUUUGGUUGGACGACGGUGGAGGUUCUUCUUG,MRKIVVAAIAVSLTTVSITASASADPSKDSKAQVSAAEAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKVKPSAASIDAAKKAGVNNGNPLDAVQQ,negative +CCAAGCAUCAGCUGG,MAAKVASTSSEEAEGSLVTEGEMGEKALPVVYKRYICSFADCGAAYNKNWKLQAHLCKHTGEKPFPCKEEGCEKGFTSLHHLTRHSLTHTGEKNFTCDSDGCDLRFTTKANMKKHFNRFHNIKICVYVCHFENCGKAFKKHNQLKVHQFSHTQQLPYECPHEGCDKRFSLPSRLKRHEKVHAGYPCKKDDSCSFVGKTWTLYLKHVAECHQDLAVCDVCNRKFRHKDYLRDHQKTHEKERTVYLCPRDGCDRSYTTAFNLRSHIQSFHEEQRPFVCEHAGCGKCFAMKKSLERHSVVHDPEKRKLKEKCPRPKRSLASRLTGYIPPKSKEKNASVSGTEKTDSLVKNKPSGTETNGSLVLDKLTIQ,negative +TTCCGGCTATGGTTAAACAAAAGACTAGGGAGGTTATTCA,PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKNSKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNRKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFYTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQK,negative +TATAACGCCCGTGTTGCTCGGTTAT,MQLPLALCLVCLLVHTAFRVVEGQGWQAFKNDATEIIPELGEYPEPPPELENNKTMNRAENGGRPPHHPFETKDVSEYSCRELHFTRYVTDGPCRSAKPVTELVCSGQCGPARLLPNAIGRGKWWRPSGPDFRCIPDRYRAQRVQLLCPGGEAPRARKVRLVASCKCKRLTRFHNQSELKDFGTEAARPQKGRKPRPRARSAKANQAELENAY,negative +GGACCUUUGUACCCCAGAUGAUAGUGAGGCGCGGCUUGAUGGGUACAAAUGGCAG,MSGGDGRGHNTGAHSTSGNINGGPTGLGVGGGASDGSGWSSENNPWGGGSGSGIHWGGGSGHGNGGGNGNSGGGSGTGGNLSAVAAPVAFGFPALSTPGAGGLAVSISAGALSAAIADIMAALKGPFKFGLWGVALYGVLPSQIAKDDPNMMSKIVTSLPADDITESPVSSLPLDKATVNVNVRVVDDVKDERQNISVVSGVPMSVPVVDAKPTERPGVFTASIPGAPVLNISVNNSTPAVQTLSPGVTNNTDKDVRPAGFTQGGNTRDAVIRFPKDSGHNAVYVSVSDVLSPDQVKQRQDEENRRQQEWDATHPVEAAERNYERARAELNQANEDVARNQERQAKAVQVYNSRKSELDAANKTLADAIAEIKQFNRFAHDPMAGGHRMWQMAGLKAQRAQTDVNNKQAAFDAAAKEKSDADAALSSAMESRKKKEDKKRSAENNLNDEKNKPRKGFKDYGHDYHPAPKTENIKGLGDLKPGIPKTPKQNGGGKRKRWTGDKGRKIYEWDSQHGELEGYRASDGQHLGSFDPKTGNQLKGPDPKRNIKKYL,negative +GTCCTAGCAGACACTCGGCCATCACGCCCATTGGTTTGCA,PHITDVVLDKANKTPLRQLDPSRLPDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFAKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRQSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPINRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDTASEATRPATLNRFSALQQTLPAENTDNRRVVQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRTRTPATKRSFSKEVEERSRERPSQPEGLRKAASLTEDRGRDPVKREATLPPVSPPKAALSVDEVEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRLGIESTLERSTIAREHMGRLLHQLLCAGHLSTAQYYQGLYETLELAEDMEIDIPHVWLYLAELITPILQEDGVPMGELFREITKPLRPMGKATSLLLEILGLLCKSMGPKKVGMLWREAGLSWREFLAEGQDVGSFVAEKKVEYTLGEESEAPGQRTLAFEELRRQLEKLLKDGGSNQRVFDWIDANLNEQQIASNTLVRALMTTVCYSAIIFETPLRVDVQVLKVRARLLQKYLCDEQKELQALYALQALVVTLEQPANLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFNWLREAEDEESDHN,negative +CAUAGGCUUACAACAGAGCGGGGGUUCUGAUGGUAGACGCCGGGACGCCC,MIPPPRRSASSTPKDYRSSRDLQPWRGVSSGDAAETSQQSRHRRDAIADGGGRLKGAAQSSPSSGTRRSGPYAQGRAMPKNENIPKPGKQRLGPRKKKLSTLKKKILLDRLERWRDKQHEGALSTPSATASSEEAKCNNPFPLCPPGELSPPPSPPATICPAVVDKSTSYGQVGGANGERSVWAITIYNLVDQEDVEDDDDHAEIERDLWDMSSAFGVVRSVQVPRGTAVQVSDAEVSAAAAAGEPAAVAAKVAFATNAEAECARDGLNGRIVGGKPLLVRIHRCDGHFCGGVCPGDPDGSGLWRVAIENLIDEEDDLDDEDEYAEISANVSAMMGCYGKLVDVQVRRSSPSKGEVQEDVATRAATTAGATQAVVVTFGSLAEAEACVQGIKGCRVGGKELDAHVVLDSERVLPSNPAFKCDQEHAHSSDVAAAVAGQGDSMMKQEAGTEPSPCVDQDTAAAVASSTEWRVVIRGLIDEDDLQDDDDDYAEVCSDVTALVSSYGAVVGLDIPRGRETGSCCYGAEPGEAVVVFRSLQEAEACARGLSGRKVAGNILDAQVLTQPAPSQQGPLQGGASGTGPPVANRERKPAKECPLPQHQASSHQSCGKVPELDGSGPGMLRGFGNRVEDCCGRPKIACTDSDEPQAIAAAAPPGQSIEGPKTTALAKAGKRIQTKYQEAAALPKPPGVRGGLPNAYVNQPPDKEVNDLVFEMLQLLFKFQERARLSDPSKAKTRRRLVIGLREVLRGVKAKKVRLLIVAPNVDAVGGEGGLDDKVVEIIDKAREAEYPVVFALSKRKIGKALGKTIKVSAVGVYSFDGANEQQKQLKRRMETISSLPSPSPRQSDPPTDDALASPPSSSACGDSQDPAGKGSRV,negative +UGGUCUCCCAAUUCUAAACUUUCUCCAUCGUAUCUGGG,MQLPLALCLVCLLVHTAFRVVEGQGWQAFKNDATEIIPELGEYPEPPPELENNKTMNRAENGGRPPHHPFETKDVSEYSCRELHFTRYVTDGPCRSAKPVTELVCSGQCGPARLLPNAIGRGKWWRPSGPDFRCIPDRYRAQRVQLLCPGGEAPRARKVRLVASCKCKRLTRFHNQSELKDFGTEAARPQKGRKPRPRARSAKANQAELENAY,negative +TCCCTTCATCATTAACCCGTCCACGCGC,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,negative +GGGAUGAAUAAUAAUAAUA,MSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEMLDRHHTHFCPLEGESWQDFLRNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAFLCQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERETPTTDSMPPLLRQAIELFDHQGAEPAFLFGLELIICGLEKQLKCESGS,negative +CTCCTCTGACTGTAACCACGGACTGCTGATGAGTCACTTTAACGTGGAGCAAAGATTAAAGCATAGGTAGTCCAGAAGCC,MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA,negative +ATAACACGACATCCATATGTCAGTGGTCTGTGTACGTACACGGTATTCGC,MSWLLFLAHRVALAALPCRRGSRGFGMFYAVRRGRKTGVFLTWNECRAQVDRFPAARFKKFATEDEAWAFVRKSASPEVSEGHENQHGQESEAKASKRLREPLDGDGHESAEPYAKHMKPSVEPAPPVSRDTFSYMGDFVVVYTDGCCSSNGRRRPRAGIGVYWGPGHPLNVGIRLPGRQTNQRAEIHAACKAIEQAKTQNINKLVLYTDSMFTINGITNWVQGWKKNGWKTSAGKEVINKEDFVALERLTQGMDIQWMHVPGHSGFIGNEEADRLAREGAKQSED,negative +AGAAAAAAACAAUCCACAGAACAGCGCGUG,MASTSRLDALPRVTCPNHPDAILVEDYRAGDMICPECDRVIDVGSEWRTFSNDKATKDPSRVGDSQNPLLSDGDLSTMIGKGTGAASFDEFGNSKYQNRRTMSSSDRAMMNAFKEITTMADRINLPRNIVDRTNNLFKQVYEQKSLKGRANDAIASACLYIACRQEGVPRTFKEICAVSRISKKEIGRCFKLILKALETSVDLITTGDFMSRFCSNLCLPKQVQMAATHIA,negative +GGCGAGAACAGGTCGTCCGAGGGTGACCCAACAAGGAAAA,MANLGYWLLALFVTMWTDVGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGTWGQPHGGGWGQPHGGSWGQPHGGSWGQPHGGGWGQGGGTHNQWNKPSKPKTNLKHVAGAAAAGAVVGGLGGYMLGSAMSRPMIHFGNDWEDRYYRENMYRYPNQVYYRPVDQYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCVTQYQKESQAYYDGRRSSSTVLFSSPPVILLISFLIFLIVG,negative +AATACGTGCTCCCTCCGCCAAAGGCGGAGGGAGCACG,MTPDIQAPFLSLLLLFPVLTVANVPTLTTSDSINPRRTTPVSTTQSSPTSSPTKETSWSTTTTLLTASSPAPSPAASPGHDGASTPTSSPAPSPAASPGHDGASTPTSSPAPSPAASPGHDGASTPTSSPAPSPAASPGHDGASTPTSSPAPSPAASPGHNGTSSPTGSPAPSPAASPGHDGASTPTSSPAPSPAASPGHNGTSSPTGSPAPSPAASPGHDGASTPTSSPAPSPAASPGHNGTSSPTGSPAPSPTASPGHDSAPSLTSSPAPSPTASPGQHGASSPTSSDTSSMTTRSMSSSMVTSAHKGTSSRATMTPVSKGTPSSVPSSETAPTAASHITRTAASSPSIALSTSSNPKTSQQLSVRVSLYFLSFRITNLQFNSSLENPQTSYYQELQRSIWGLILQIYKQRDFLGLSEIKFRPGSVVVELTLAFREGTTAEWVKAQFSQLEAHAASYNLTISGVSVYSAPFPSSAQAGSGVPGWGIALLVLVCVLVALAIIYLIALVVCQCGRKKCEQLDVFPTLDAYHPMSEYSTYHTHGRYVPPGSTKRSPYEEVSAGNGGSNLSYTNLAATSANL,negative +UCAUGGUGUCUUUCCACAGCUCUUCCCAUGAUCGCCCGG,QELLCAASLISDRWVLTAAHCLLYPPWDKNFTVNDILVRIGKYARSRYERNMEKISTLEKIIIHPGYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDKQIVTSLLQAGHKGRVTGWGNLKEMWTVNMNEVQPSVLQMVNLPLVERPICKASTGIRVTDNMFCAGYKPEEGKRGDACEGDSGGPFVMKNPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIRKMVDRFG,negative +ACAAAGCUGGAGUACUUACCGAACAUCCGUCUAACCCCU,MDKFWWHAAWGLCLVPLSLAQIDLNITCRFAGVFHVEKNGRYSISRTEAADLCKAFNSTLPTMAQMEKALSIGFETCRYGFIEGHVVIPRIHPNSICAANNTGVYILTSNTSQYDTYCFNASAPPEEDCTSVTDLPNAFDGPITITIVNRDGTRYVQKGEYRTNPEDIYPSNPTDDDVSSGSSSERSSTSGGYIFYTFSTVHPIPDEDSPWITDSTDRIPATTLMSTSATATETATKRQETWDWFSWLFLPSESKNHLHTTTQMAGTSSNTISAGWEPNEENEDERDRHLSFSGSGIDDDEDFISSTISTTPRAFDHTKQNQDWTQWNPSHSNPEVLLQTTTRMTDVDRNGTTAYEGNWNPEAHPPLIHHEHHEEEETPHSTSTIQATPSSTTEETATQKEQWFGNRWHEGYRQTPKEDSHSTTGTAAASAHTSHPMQGRTTPSPEDSSWTDFFNPISHPMGRGHQAGRRMDMDSSHSITLQPTANPNTGLVEDLDRTGPLSMTTQQSNSQSFSTSHEGLEEDKDHPTTSTLTSSNRNDVTGGRRDPNHSEGSTTLLEGYTSHYPHTKESRTFIPVTSAKTGSFGVTAVTVGDSNSNVNRSLSGDQDTFHPSGGSHTTHGSESDGHSHGSQEGGANTTSGPIRTPQIPEWLIILASLLALALILAVCIAVNSRRRCGQKKKLVINSGNGAVEDRKPSGLNGEASKSQEMVHLVNKESSETPDQFMTADETRNLQNVDMKIGV,negative +GGGAGCTCAGAATAAACGCTCAAAATGCGGGGTGGGTGGGGTGGTTGAAGAATATTCGACATGAGGCCCGGATC,MSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEMLDRHHTHFCPLEGESWQDFLRNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAFLCQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERETPTTDSMPPLLRQAIELFDHQGAEPAFLFGLELIICGLEKQLKCESGS,negative +TCCCTACGGCGCTAACGTATAAGTCGCCTGCATCACGGCCAGATTTGCCACCGTGCTACAAC,IMEIRTVAVGIVAIKGVESEYYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHSGGEMFVALNQKGLPVKGKKTKKEQKTAHFLPMAIT,negative +TCCCACGCATTCTCCACATCATTTGAATAGTGTGGTCACTTCCAGTCCCGCAGGGCACACCCTTTCTGTCCTTCCGTCAC,MQRTKEAVKASDGNLLGDPGRIPLSKRESIKWQRPRFTRQALMRCCLIKWILSSAAPQGSDSSDSELELSTVRHQPEGLDQLQAQTKFTKKELQSLYRGFKNECPTGLVDEDTFKLIYSQFFPQGDATTYAHFLFNAFDADGNGAIHFEDFVVGLSILLRGTVHEKLKWAFNLYDINKDGCITKEEMLAIMKSIYDMMGRHTYPILREDAPLEHVERFFQKMDRNQDGVVTIDEFLETCQKDENIMNSMQLFENVI,negative +ACACCCACCGCAGGCAGACGCAACGCCTCGGAGACTAGCC,MLNQLDNLTERVRGSNKLVDRWLHVRKHLLVAYYNLVGIKPGKESYMRLNEKALDDFCQSLVDYLSAGHFSIYERILHKLEGNGQLARAAKIWPQLEANTQQIMDYYDSSLETAIDHDNYLEFQQVLSDIGEALEARFVLEDKLILLVLDAARVKHPA,negative +CCUGUGUCUUGUGUGUGUGUUUUGUUUCUGGUCUA,MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC,negative +AAGACGGCCGGCGCCAUAGCCGAGAUCCGAGGUUGUAC,QELLCAASLISDRWVLTAAHCLLYPPWDKNFTVNDILVRIGKYARSRYERNMEKISTLEKIIIHPGYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDKQIVTSLLQAGHKGRVTGWGNLKEMWTVNMNEVQPSVLQMVNLPLVERPICKASTGIRVTDNMFCAGYKPEEGKRGDACEGDSGGPFVMKNPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIRKMVDRFG,negative +AAGACCACACAUAAGAAACAGGGAACAGCGUUCAA,MDHLNEATQGKEHSEMSNNVSDPKGPPAKIARLEQNGSPLGRGRLGSTGAKMQGVPLKHSGHLMKTNLRKGTMLPVFCVVEHYENAIEYDCKEEHAEFVLVRKDMLFNQLIEMALLSLGYSHSSAAQAKGLIQVGKWNPVPLSYVTDAPDATVADMLQDVYHVVTLKIQLHSCPKLEDLPPEQWSHTTVRNALKDLLKDMNQSSLAKECPLSQSMISSIVNSTYYANVSAAKCQEFGRWYKHFKKTKDMMVEMDSLSELSQQGANHVNFGQQPVPGNTAEQPPSPAQLSHGSQPSVRTPLPNLHPGLVSTPISPQLVNQQLVMAQLLNQQYAVNRLLAQQSLNQQYLNHPPPVSRSMNKPLEQQVSTNTEVSSEIYQWVRDELKRAGISQAVFARVAFNRTQGLLSEILRKEEDPKTASQSLLVNLRAMQNFLQLPEAERDRIYQDERERSLNAASAMGPAPLISTPPSRPPQVKTATIATERNGKPENNTMNINASIYDEIQQEMKRAKVSQALFAKVAATKSQGWLCELLRWKEDPSPENRTLWENLSMIRRFLSLPQPERDAIYEQESNAVHHHGDRPPHIIHVPAEQIQQQQQQQQQQQQQQQAPPPPQPQQQPQTGPRLPPRQPTVASPAESDEENRQKTRPRTKISVEALGILQSFIQDVGLYPDEEAIQTLSAQLDLPKYTIIKFFQNQRYYLKHHGKLKDNSGLEVDVAEYKEEELLKDLEESVQDKNTNTLFSVKLEEELSVEGNTDINTDLKD,negative +AGTAATACGACTCACTATAGGGAGAATTCCGACCAGAAGGGUUAGCGGUCGUCUUAAGUAGUUUUUGGUCCTTTCCTCTCTCCTTCCTCTTCT,RRIKRLEQEKLELSRKLQESTQTVQALQYSTVDGPLTASKDLEIKNLKEEIEKLRKQVTESSHLEQQLEEANAVRQELDDAFRQIKAYEKQIKTLQQEREDLNKELVQASERLKNQSKELKDAHCQRKLAMQEFMEINER,negative +CCCTTCATCATTAACCCGTCCACGCGC,MVKSHIGSWILVLFVAMWSDVGLCKKRPKPGGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGTHGQWNKPSKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGSDYEDRYYRENMHRYPNQVYYRPVDQYSNQNNFVHDCVNITVKEHTVTTTTKGENFTETDIKMMERVVEQMCITQYQRESQAYYQRGASVILFSSPPVILLISFLIFLIVG,negative +GAATGAGGAATAATCTAGCTCCTTCGCTGA,MSPQRDRINAFYKDNPHPKGSRIVINREHLMIDRPYVLLAVLFVMFLSLIGLLAIAGIRLHRAAIYTAEIHKSLSTNLDVTNSIEHQVKDVLTPLFKIIGDEVGLRTPQRFTDLVKFISDKIKFLNPDREYDFRDLTWCINPPERIKLDYDQYCADVAAEELMNALVNSTLLEARATNQFLAVSKGNCSGPTTIRGQFSNMSLSLLDLYLSRGYNVSSIVTMTSQGMYGGTYLVEKPNLSSKGSELSQLSMHRVFEVGVIRNPGLGAPVFHMTNYFEQPVSNDFSNCMVALGELKFAALCHREDSITIPYQGSGKDVSFQLVKLGVWKSPTDMQSWVPLSTDDPVIDRLYLSSHRGVIADNQAKWAVPTTRTDDKLRMETCFQQACKGKIQALCENPDWAPLKDNRIPSYGVLSVNLSLTVELKIKIASGFGPLITHGSGMDLYKSNHNNMYWLTIPPMKNLALGVINTLEWIPRFRVSPNLFTVPIKEAGEDCHAPTYLPAEVDGDVKLSSNLVILPGQDLQYVLATYDTSRVEHAVVYYVYSPSRSFSYFYPFRLPIKGVPIELQVECFTWDQKLWCRHFCVLADSGSGGHITHSGMVGMGVSCTVTREDGTNRR,negative +GGGAAAAGAGACGGCCGGCGCCAUAGCCGAGAUCCGAGGUGUUGA,ASFTCLAIWALASAGVVPLVLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAAFFFVPVIISTVCYVSIIRCLSSSAVANRSKK,negative +GGCGAGAACAGGTCGTCCGAGGGTGACCCAACAAGGAAAA,IMEIRTVAVGIVAIKGVESEYYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHSGGEMFVALNQKGLPVKGKKTKKEQKTAHFLPMAIT,negative +GGGUUACCUAGGUGUAGAUGCUCACUUACACAAACCUGUAGUUUUAUGCUUCACAUAUCGCACAGGACGCUUAAGUGACGUCUGAACUGCUUCGAA,MSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA,negative +TCTCATGCGCCGAGTGTGAGTTTACCTTCGT,MAVAQELYGFPASKLDSFVAQWLQPTREWKEEVLETVQTVEQFLRQENFREDRGPARDVRVLKVLKVGCFGNGTVLRSTTDVELVVFLSCFHSFQEEAKHHQAVLRLIQKRMYYCQELMDLGLSNLSVTNRVPSSLIFTIQTRETWETITVTVVPAYRALGPSCPSSEVYANLIKANGYPGNFSPSFSELQRNFVKHRPTKLKSLLRLVKHWYQQYVRDKCPRANLPPLYALELLTVYAWEAGTREDANFRLDEGLATVMELLQDHELLCIYWTKHYTLQHPVIEACVRRQLRGQRPIILDPADPTNNVAEGYRWDIVAQRANQCLKQDCCYDNRDSPVPSWRVKRAPDIQVTVQEWGHSDLTFWVNPYEPIKKLKEKIQLSQGYLGLQRLSFQEPGGERQLIRSHCTLAYYGIFCDTHICLLDTISPEIQVFVKNPDGRSHAYAIHPLDYVLNLKQQIEDRQGLRCQEQRLEFQGHILEDWFDFKSYGIQDSVTVILSKTTEGAAPFVPS,negative +CCCCACCGACCGAUGAUCUUGAGCGUACAUCGCGGG,MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC,negative +AUCGGUCUGAACCGGCCCAGCAGACUGCGACGGCACGAU,VVIRSNNFTDNAKTIIVQLNESIAINCTRPNNNTRKSIHIGPGRAFYTTGDIIGNIRQAHCNLSRTKWENTLKQIAKKLREQFGNKTIVFNH,negative +CAAACAATCAAACAGCAGTGGGGTG,MLSWGYFLFLLPTLPGAQSQVQLVESGGDVRKPGDSLRLSCKGSGFTFSNYWLGWVRQAPGKALNGSLPLTPLAAAPTYIPGVSGRFTISRDNARALLHLDMSDLRPEDTGRYHCER,negative +GAAUAUCUUCCGAAGCCGAACGGGAAAACCGGCAUCU,MSDLANSEKYYDEDPYGFEDESAPITAEDSWAVISAFFREKGLVSQQLDSFNQFVDYTLQDIICEDSTLILEQLAQHTTESDNISRKYEISFGKIYVTKPMVNESDGVTHALYPQEARLRNLTYSSGLFVDVKKRTYEAIDVPGRELKYELIAEESEDDSESGKVFIGRLPIMLRSKNCYLSEATESDLYKLKECPFDMGGYFIINGSEKVLIAQERSAGNIVQVFKKAAPSPISHVAEIRSALEKGSRFISTLQVKLYGREGSSARTIKATLPYIKQDIPIVIIFRALGIIPDGEILEHICYDVNDWQMLEMLKPCVEDGFVIQDRETALDFIGRRGTALGIKKEKRIQYAKDILQKEFLPHITQLEGFESRKAFFLGYMINRLLLCALDRKDQDDRDHFGKKRLDLAGPLLAQLFKTLFKKLTKDIFRYMQRTVEEAHDFNMKLAINAKTITSGLKYALATGNWGEQKKAMSSRAGVSQVLNRYTYSSTLSHLRRTNTPIGRDGKLAKPRQLHNTHWGLVCPAETPEGQACGLVKNLSLMSCISVGTDPMPIITFLSEWGMEPLEDYVPHQSPDATRVFVNGVWHGVHRNPARLMETLRTLRRKGDINPEVSMIRDIREKELKIFTDAGRVYRPLFIVEDDESLGHKELKVRKGHIAKLMATEYQDIEGGFEDVEEYTWSSLLNEGLVEYIDAEEEESILIAMQPEDLEPAEANEENDLDVDPAKRIRVSHHATTFTHCEIHPSMILGVAASIIPFPDHNQSPRNTYQSAMGKQAMGVFLTNYNVRMDTMANILYYPQKPLGTTRAMEYLKFRELPAGQNAIVAIACYSGYNQEDSMIMNQSSIDRGLFRSLFFRSYMDQEKKYGMSITETFEKPQRTNTLRMKHGTYDKLDDDGLIAPGVRVSGEDVIIGKTTPISPDEEELGQRTAYHSKRDASTPLRSTENGIVDQVLVTTNQDGLKFVKVRVRTTKIPQIGDKFASRHGQKGTIGITYRREDMPFTAEGIVPDLIINPHAIPSRMTVAHLIECLLSKVAALSGNEGDASPFTDITVEGISKLLREHGYQSRGFEVMYNGHTGKKLMAQIFFGPTYYQRLRHMVDDKIHARARGPMQVLTRQPVEGRSRDGGLRFGEMERDCMIAHGAASFLKERLMEASDAFRVHICGICGLMTVIAKLNHNQFECKGCDNKIDIYQIHIPYAAKLLFQELMAMNITPRLYTDRSRDF,negative +GGGAGGACGAUGCGGAUCAGCCAUGUUUACGUCACUCCUUGUCAAUCCUCAUCGGCAGACGACUCGCCCGA,MGCRRTREGPSKAMIFPWKCQSTQRDLWNIFKLWGWTMLCCDFLAHHGTDCWTYHYSEKPMNWQRARRFCRDNYTDLVAIQNKAEIEYLEKTLPFSRSYYWIGIRKIGGIWTWVGTNKSLTEEAENWGDGEPNNKKNKEDCVEIYIKRNKDAGKWNDDACHKLKAALCYTASCQPWSCSGHGECVEIINNYTCNCDVGYYGPQCQFVIQCEPLEAPELGTMDCTHPLGNFSFSSQCAFSCSEGTNLTGIEETTCGPFGNWSSPEPTCQVIQCEPLSAPDLGIMNCSHPLASFSFTSACTFICSEGTELIGKKKTICESSGIWSNPSPICQKLDKSFSMIKEGDYNPLFIPVAVMVTAFSGLAFIIWLARRLKKGM,negative +AACUAGCAGGCAGAGAAGAGUGGGUGCGACCACAGGAUGUUAUGGCCUG,MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPGPHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR,negative +UCAAUCGGCGCUUUACUCUUGCGCUCACCGUGCCC,MAWYWWRRRRRRGWWKPRRRRWRRRRARRRGPARRHRARRRIVRHPCNGQTSSGNRVPRSVQAVDPKYVSLQLVWHSWDFRRGLFGQAGIKRMQQESDALTLSPVHRPKRPKRDTQVKEKTPEKDSDSAVQLRRLQPWIHSSQETKDEEEEIPEGPVQEQLLQQLQQQRLLRVQLESIAQEVLKIRRGHSLHPLLSSHA,negative +TCCCTTCATCATTAACCCGTCCACGCGC,MSAPASTTQATGSTTSTTTKTAGATPATASGLFTIPDGDFFSTARAVVASDAVATNEDLSEIEAVWKDMKVPTDTMAQAAWDLVRHCADVGSSAQTEMIDTGPYSNGISRARLAAAIKEVCTLRQFCMKYAPVVWNWMLTNNSPPANWQAQGFKPEHKFAAFDFFNGVTNPAAIMPKEGLIRPPSEAEMNAAQTAAFVKITKARAQSNDFASLDAAVTRGRITGTTTAEAVVTLPPP,negative +GGGAGAAUUCCGACCAGAAGUUCGAUACGCCGUGGGGUGACGUUGGCUGCCCUUUCCUCUCUCCUCCUUCUUCU,MANLGYWLLALFVTMWTDVGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGTWGQPHGGGWGQPHGGSWGQPHGGSWGQPHGGGWGQGGGTHNQWNKPSKPKTNLKHVAGAAAAGAVVGGLGGYMLGSAMSRPMIHFGNDWEDRYYRENMYRYPNQVYYRPVDQYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCVTQYQKESQAYYDGRRSSSTVLFSSPPVILLISFLIFLIVG,negative +UUAACUCCCAACGCAUCAAUCCCGAUCCGUGACUCCGCC,PHITDVVLDKANKTPLRQLDPSRLPDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFAKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRQSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPINRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDTASEATRPATLNRFSALQQTLPAENTDNRRVVQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRTRTPATKRSFSKEVEERSRERPSQPEGLRKAASLTEDRGRDPVKREATLPPVSPPKAALSVDEVEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRLGIESTLERSTIAREHMGRLLHQLLCAGHLSTAQYYQGLYETLELAEDMEIDIPHVWLYLAELITPILQEDGVPMGELFREITKPLRPMGKATSLLLEILGLLCKSMGPKKVGMLWREAGLSWREFLAEGQDVGSFVAEKKVEYTLGEESEAPGQRTLAFEELRRQLEKLLKDGGSNQRVFDWIDANLNEQQIASNTLVRALMTTVCYSAIIFETPLRVDVQVLKVRARLLQKYLCDEQKELQALYALQALVVTLEQPANLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFNWLREAEDEESDHN,negative +GUAAGGGUUCACUCUGCAUCGACAACUGGA,MAWYWWRRRRRRGWWKPRRRRWRRRRARRRGPARRHRARRRIVRHPCNGQTSSGNRVPRSVQAVDPKYVSLQLVWHSWDFRRGLFGQAGIKRMQQESDALTLSPVHRPKRPKRDTQVKEKTPEKDSDSAVQLRRLQPWIHSSQETKDEEEEIPEGPVQEQLLQQLQQQRLLRVQLESIAQEVLKIRRGHSLHPLLSSHA,negative +GGGAGGACGATGCGGCATGCGTCTGACCTACGTGCCAAGCATTTGTGTAACCCGTCAGACGACTCGCCCGA,MDSTNYISKLFEYAQRQGQISDIKFEEVGTDGPDHLKTFTLRVVIKGHAYPNGVGKTKKEAKRNAAKHALIGMMETTEQKDASVSCPPSPAPSPAPPVRAVISQPKYVSWLNEHSQKNKLSLKALEGARVGPNNTSQCCRYVVGEKEYPEGFGNTKKEAKEEAAMQVYLELCGGSQTTGTVDENCNGTTGKHKEELNGKVVVLSEKVEHMNMSPAQNVPEQYSFITTEETNFIGILNHYCQKTKRFLDFKLVEKSGPSHNPQFVYKVLIDKREYPDGLGKTAKEAKQQAAQLAWSALQEQSDWNSQVSCRSTVSEEGGLSSLTPSSTWESQDATPSSLSIAGSTSESIIFSDSVNVSSPKDESPVNVKPKIRLAANFQMSPVKTKQEGPNLKGNDLGTLSSGRTSNQPVISRFSSEFDSIENIGKGGFGHVYKARRKLEQKYFAVKIVRSKGKAKREVGALADLQHPNIVRYYTAWLEDTAYRCDTASESDTTSDSGSSSSSEFLYIQMELCDKRTLKVWIDERNAHRKPKRREESLSITQQIVNGVEYIHSKKLLHRDLKPANIMFGMSDGEGKGEVKIGDFGLVTAEDNDNDENLLERTKKTGTVSYMAPEQRNQTSYDRKVDIFALGLIYFEPLWDLSGMEKAKVWNDVRSQRFPQQFNSQFTLENKVIESLLCANPEERPDARQLKTKLNECSRVLTRVHNIHQDNRTI,negative +CTTCTGCCCGCCTCCTTCCCGCACTTGCAAACCTTCATGGTCTCGTGCTTGAGTGGTTGGAGACGAGATAGGCGGACACT,MAAKVASTSSEEAEGSLVTEGEMGEKALPVVYKRYICSFADCGAAYNKNWKLQAHLCKHTGEKPFPCKEEGCEKGFTSLHHLTRHSLTHTGEKNFTCDSDGCDLRFTTKANMKKHFNRFHNIKICVYVCHFENCGKAFKKHNQLKVHQFSHTQQLPYECPHEGCDKRFSLPSRLKRHEKVHAGYPCKKDDSCSFVGKTWTLYLKHVAECHQDLAVCDVCNRKFRHKDYLRDHQKTHEKERTVYLCPRDGCDRSYTTAFNLRSHIQSFHEEQRPFVCEHAGCGKCFAMKKSLERHSVVHDPEKRKLKEKCPRPKRSLASRLTGYIPPKSKEKNASVSGTEKTDSLVKNKPSGTETNGSLVLDKLTIQ,negative +CAGCTCAGAAGCTTGATCCTGTGAGGAATGCTCATGCATAGCAAGGGCTAAACACGGCGACTCGAAGTCGTGCATCTGCA,MSEAEARPTNFIRQIIDEDLASGKHTTVHTRFPPEPNGYLHIGHAKSICLNFGIAQDYKGQCNLRFDDTNPVKEDIEYVESIKNDVEWLGFHWSGNVRYSSDYFDQLHAYAIELINKGLAYVDELTPEQIREYRGTLTQPGKNSPYRDRSVEENLALFEKMRAGGFEEGKACLRAKIDMASPFIVMRDPVLYRIKFAEHHQTGNKWCIYPMYDFTHCISDALEGITHSLCTLEFQDNRRLYDWVLDNITIPVHPRQYEFSRLNLEYTVMSKRKLNLLVTDKHVEGWDDPRMPTISGLRRRGYTAASIREFCKRIGVTKQDNTIEMASLESCIREDLNENAPRAMAVIDPVKLVIENYQGEGEMVTMPNHPNKPEMGSRQVPFSGEIWIDRADFREEANKQYKRLVLGKEVRLRNAYVIKAERVEKDAEGNITTIFCTYDADTLSKDPADGRKVKGVIHWVSAAHALPVEIRLYDRLFSVPNPGAADDFLSVINPESLVIKQGFAEPSLKDAVAGKAFQFEREGYFCLDSRHSTAEKPVFNRTVGLRDTWAKVGE,negative +CAGGAAACAGCAAGACAAACGAUGGGGAGCGUAAGACUGCGAGUGUCGGA,MNRNCASPEEGGTTEQLVKEASDIVERDGFENKKKPPTLKLEHVEVVGEKSPTPATVYDLFKKYKKPDIVTNSNGDDMNVGFDQLSSDEKNGFLRKLQMLTVSSRKSVKVVGESTPSSAGRLLKKFAPSRKPTEKISVDEPPSRFNFFGRSTKKLSDSDRPSSLPKKKSARRLLFGKEEQKPEPEVVKNRVLPAMTSQQSAKGAPIPINKPYRYQGPRGSLETPTDSPAKISSNSSSSSPIPPVPTRNHFTSMNEESPSKKRTFSRQGLSNRDNLSNGSWHGELPPRDYTSPTFSRKIFVGGVPWDITEAALKDSFGEFGSCAVEWPGQEARYRSGQSNIAPLTNLRNQSKYAGQAATGYVYMIFEDERAVASLLHECSQEIGGAGEWYFKIRAQRSKSTEIRQVQIIPWVTSDSMFCEDESLLETGIEPKRTVFVGALHGMMTAQVLHWIMEDCFGSVECVQLDTDKFKYPIGSGRVTFREHGAYFKAIEMGYLHVHTSKFRKRVQIDPFLESTSCMVCTTESAQCFCRNRNCFKYYCHTCWAIDHGKDNADDVHVPVIVPSSASKAYAGPHRRPHLTSNSLSKSHGCSTNNQLSHVLSPGFPMIVGGPSQTLSALYGYIQNNQQMMLTPAVYETPMTPPSNESNAKRRSFTEFQNPAIFFNPSSMMTPQKSATCSETPVPAFFTNSAAFLTPNSNYYGSPNHSSSNISQSPQQYYGANLYYGYMPPQVAYDGSTNGSKLSPIHVPHIPNYQ,negative +CACCUACCUAAUUAUUAAACUUUGGGCAGUAUCCCGCUUUGCUUCUUAUC,MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA,negative +CTTCTGCCCGCCTCCTTCCGGAATGATGCGTAAAGGACCGAGGGTGCTTGCCATAATCGGAGACGAGATAGGCGGACACT,MGCRRTREGPSKAMIFPWKCQSTQRDLWNIFKLWGWTMLCCDFLAHHGTDCWTYHYSEKPMNWQRARRFCRDNYTDLVAIQNKAEIEYLEKTLPFSRSYYWIGIRKIGGIWTWVGTNKSLTEEAENWGDGEPNNKKNKEDCVEIYIKRNKDAGKWNDDACHKLKAALCYTASCQPWSCSGHGECVEIINNYTCNCDVGYYGPQCQFVIQCEPLEAPELGTMDCTHPLGNFSFSSQCAFSCSEGTNLTGIEETTCGPFGNWSSPEPTCQVIQCEPLSAPDLGIMNCSHPLASFSFTSACTFICSEGTELIGKKKTICESSGIWSNPSPICQKLDKSFSMIKEGDYNPLFIPVAVMVTAFSGLAFIIWLARRLKKGM,negative +AATACGACTCACTATAGAGGGAGGACGATGCGGGATGGACGCTTATCCGCATAGAGGTTTACTACTTCGGAGACTGCCGATACAGACGACGGA,MTVFLSFAFLAAILTHIGCSNQRRSPENSGRRYNRIQHGQCAYTFILPEHDGNCRESTTDQYNTNALQRDAPHVEPDFSSQKLQHLEHVMENYTQWLQKLENYIVENMKSEMAQIQQNAVQNHTATMLEIGTSLLSQTAEQTRKLTDVETQVLNQTSRLEIQLLENSLSTYKLEKQLLQQTNEILKIHEKNSLLEHKILEMEGKHKEELDTLKEEKENLQGLVTRQTYIIQELEKQLNRATTNNSVLQKQQLELMDTVHNLVNLCTKEGVLLKGGKREEEKPFRDCADVYQAGFNKSGIYTIYINNMPEPKKVFCNMDVNGGGWTVIQHREDGSLDFQRGWKEYKMGFGNPSGEYWLGNEFIFAITSQRQYMLRIELMDWEGNRAYSQYDRFHIGNEKQNYRLYLKGHTGTAGKQSSLILHGADFSTKDADNDNCMCKCALMLTGGWWFDACGPSNLNGMFYTAGQNHGKLNGIKWHYFKGPSYSLRSTTMMIRPLDF,negative +AATACCCTCCCTTCGGTGCAAAGCACCGAAGGGAGGG,MSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEMLDRHHTHFCPLEGESWQDFLRNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAFLCQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERETPTTDSMPPLLRQAIELFDHQGAEPAFLFGLELIICGLEKQLKCESGS,negative +TCAGACACTTTGCCAAAAAACATGATACAAGTTCGCTGCC,MNQTAILICCLIFLTLSGIQGVPLSRTVRCTCISISNQPVNPRSLEKLEIIPASQFCPRVEIIATMKKKGEKRCLNPESKAIKNLLKAVSKERSKRSP,negative +CTTCTGCCCGCCTCCTTCCAGAGTAGCCAAGCGGAGAGTATTTTTGACTGCTTCCCCCGGAGACGAGATAGGCGGACACT,VFTDNSSPPAVPQSFQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGFGAYMSKAHGVDPNIRTGVRTITTGSPITYSTYGKFLADGGCSGGAYDIIICDECHSTDATSILGIGTVLDQAETAGARLVVLATATPPGSVTVSHPNIEEVALSTTGEIPFYGKAIPLEVIKGGRHLIFCHSKKKCDELAAKLVALGINAVAYYRGLDVSVIPTSGDVVVVSTDALMTGFTGDFDSVIDCNTCVTQTVDFSLDPTFTIETTTLPQDAVSRTQRRGRTGRGKPGIYRFVAPGERPSGMFDSSVLCECYDAGCAWYELTPAETTVRLRAYMNTPGLPVCQDHLEFWEGVFTGLTHIDAHFLSQTKQSGENFPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPTLHGPTPLLYRLGAVQNEVT,negative +AATACGACTCACTATAGAGGGAGGACGATGCGGGGTGCTTCGAGCGTAGGAAGAAAGCCGGGGGCTGCAGATAATGTATAGCCAGACGACGGA,MHGDTPTLHEYMLDLQPETTDLYCYEQLNDSSEEEDEIDGPAGQAEPDRAHYNIVTFCCKCDSTLRLCVQSTHVDIRTLEDLLMGTLGIVCPICSQKP,negative +GGTGATCATGGCAGTGTACGCGGGCGGACA,MDSTNYISKLFEYAQRQGQISDIKFEEVGTDGPDHLKTFTLRVVIKGHAYPNGVGKTKKEAKRNAAKHALIGMMETTEQKDASVSCPPSPAPSPAPPVRAVISQPKYVSWLNEHSQKNKLSLKALEGARVGPNNTSQCCRYVVGEKEYPEGFGNTKKEAKEEAAMQVYLELCGGSQTTGTVDENCNGTTGKHKEELNGKVVVLSEKVEHMNMSPAQNVPEQYSFITTEETNFIGILNHYCQKTKRFLDFKLVEKSGPSHNPQFVYKVLIDKREYPDGLGKTAKEAKQQAAQLAWSALQEQSDWNSQVSCRSTVSEEGGLSSLTPSSTWESQDATPSSLSIAGSTSESIIFSDSVNVSSPKDESPVNVKPKIRLAANFQMSPVKTKQEGPNLKGNDLGTLSSGRTSNQPVISRFSSEFDSIENIGKGGFGHVYKARRKLEQKYFAVKIVRSKGKAKREVGALADLQHPNIVRYYTAWLEDTAYRCDTASESDTTSDSGSSSSSEFLYIQMELCDKRTLKVWIDERNAHRKPKRREESLSITQQIVNGVEYIHSKKLLHRDLKPANIMFGMSDGEGKGEVKIGDFGLVTAEDNDNDENLLERTKKTGTVSYMAPEQRNQTSYDRKVDIFALGLIYFEPLWDLSGMEKAKVWNDVRSQRFPQQFNSQFTLENKVIESLLCANPEERPDARQLKTKLNECSRVLTRVHNIHQDNRTI,negative +ACAGATACGGAACTACAGAGGTCAATTACGGTGGCCACGC,MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP,negative +CUUGCUGCAGAGGGUCCAGAAUAUGUGUGACACUGCGUCGACGGGUUAAG,MTSHYVIAIFALMSSCLATAGPEPGALCELSPVSASHPVQALMESFTVLSGCASRGTTGLPQEVHVLNLRTAGQGPGQLQREVTLHLNPISSVHIHHKSVVFLLNSPHPLVWHLKTERLATGVSRLFLVSEGSVVQFSSANFSLTAETEERNFPHGNEHLLNWARKEYGAVTSFTELKIARNIYIKVGEDQVFPPKCNIGKNFLSLNYLAEYLQPKAAEGCVMSSQPQNEEVHIIELITPNSNPYSAFQVDITIDIRPSQEDLEVVKNLILILKCKKSVNWVIKSFDVKGSLKIIAPNSIGFGKESERSMTMTKSIRDDIPSTQGNLVKWALDNGYSPITSYTMAPVANRFHLRLENNAEEMGDEEVHTIPPELRILLDPGALPALQNPPIRGGEGQNGGLPFPFPDISRRVWNEEGEDGLPRPKDPVIPSIQLFPGLREPEEVQGSVDIALSVKCDNEKMIVAVEKDSFQASGYSGMDVTLLDPTCKAKMNGTHFVLESPLNGCGTRPRWSALDGVVYYNSIVIQVPALGDSSGWPDGYEDLESGDNGFPGDMDEGDASLFTRPEIVVFNCSLQQVRNPSSFQEQPHGNITFNMELYNTDLFLVPSQGVFSVPENGHVYVEVSVTKAEQELGFAIQTCFISPYSNPDRMSHYTIIENICPKDESVKFYSPKRVHFPIPQADMDKKRFSFVFKPVFNTSLLFLQCELTLCTKMEKHPQKLPKCVPPDEACTSLDASIIWAMMQNKKTFTKPLAVIHHEAESKEKGPSMKEPNPISPPIFHGLDTLTVMGIAFAAFVIGALLTGALWYIYSHTGETAGRQQVPTSPPASENSSAAHSIGSTQSTPCSSSSTA,negative +GAATGAGGAATAATCTAGCTCCTTCGCTGA,QDRPIKFSTEGATSQSYKQFIEALRERLRGGLIHDIPVLPDPTTLQERNRYITVELSNSDTESIEVGIDVTNAYVVAYRAGTQSYFLRDAPSSASDYLFTGTDQHSLPFYGTYGDLERWAHQSRQQIPLGLQALTHGISFFRSGGNDNEEKARTLIVIIQMVAEAARFRYISNRVRVSIQTGTAFQPDAAMISLENNWDNLSRGVQESVQDTFPNQVTLTNIRNEPVIVDSLSHPTVAVLALMLFVCNPPNANQSPLLIRSIVEKSKICSSRYEPTVRIGGRDGMCVDVYDNGYHNGNRIIMWKCKDRLEENQLWTLKSDKTIRSNGKCLTTYGYAPGSYVMIYDCTSAVAEATYWEIWDNGTIINPKSALVLSAESSSMGGTLTVQTNEYLMRQGWRTGNNTSPFVTSISGYSDLCMQAQGSNVWMADCDSNKKEQQWALYTDGSIRSVQNTNNCLTSKDHKQGSTILLMGCSNGWASQRWVFKNDGSIYSLYDDMVMDVKGSDPSLKQIILWPYTGKPNQIWLTLF,negative +GGGAGGGAAUCAGUGAAUGCUUAUACAUCCCUCCUUGAGCAGUCGAUUAGUUUCGACAGGAGGCUCAC,MGVHECPAWLWLLLSLLSLPLGLPVLGAPPRLICDSRVLERYLLEAKEAENITTGCAEHCSLNENITVPDTKVNFYAWKRMEVGQQAVEVWQGLALLSEAVLRGQALLVNSSQPWEPLQLHVDKAVSGLRSLTTLLRALGAQKEAISPPDAASAAPLRTITADTFRKLFRVYSNFLRGKLKLYTGEACRTGDR,negative +UGUUUGGCUUGGCUCUGCAUCGACAGGUGGUU,MDKLVVNYYEYKHPIINKDLAIGAHGGKKFPTLGAWYDVINEYEFQTRCPIILKNSHRNKHFTFACHLKNCPFKVLLSYAGNAASSETSSPSANNNTNPPGTPDHIHHHSNNMNNEDNDNNNGSNNKVSNDSKLDFVTDDLEYHLANTHPDDTNDKVESRSNEVNGNNDDDADANNIFKQQGVTIKNDTEDDSINKASIDRGLDDESGPTHGNDSGNHRHNEEDDVHTQMTKNYSDVVNDEDINVAIANAVANVDSQSNNKHDGKDDDATNNNDGQDNNTNNDHNNNSNINNNNVGSHGISSHSPSSIRDTSMNLDVFNSATDDIPGPFVVTKIEPYHSHPLEDNLSLGKFILTKIPKILQNDLKFDQILESSYNNSNHTVSKFKVSHYVEESGLLDILMQRYGLTAEDFEKRLLSQIARRITTYKARFVLKKKKMGEYNDLQPSSSSNNNNNNDGELSGTNLRSNSIDYAKHQEISSAGTSSNTTKNVNNNKNDSNDDNNGNNNNDASNLMESVLDKTSSHRYQPKKMPSVNKWSKPDQITHSDVSMVGLDESNDGGNENVHPTLAEVDAQEARETAQLAIDKINSYKRSIDDKNGDGHNNSSRNVVDENLINDMDSEDAHKSKRQHLSDITLEERNEDDKLPHEVAEQLRLLSSHLKEVENLHQNNDDDVDDVMVDVDVESQYNKNTTHHNNHHSQPHHDEEDVAGLIGKADDEEDLSDENIQPELRGQ,negative +GGGAGAGCGGAAGCGUGCUGGGCCGGAGUUGAGGCGUAGAUGGUUCAGAUCCGAACGAUGAAGCAUAACCCAGAGGUCGAUGGAUCC,SESGFNLSCQCLGFGSGHFKCDSSKWCHDNGVNYKIGEKWDRQGENGQMMSCTCLGNGKGEF,negative +CAAGAAGUGGAAAUGCGCAGCGACCAUGAAACCUCGCAUGGUUCAUCGAUUGUUUGGAUAGUGUCUGUGUG,MCLSEGIMCSIPPYLQFVFRYPLKSYSFGTKEPNYERDRSVPARFQRLQEDFEKYGMRRSVEGILLVHEHNLPHVLLLQLGTFFKLPGGELHPGEEEIEGLKRLLSEMLGRTDGIPVDWIPEDCIGNWWRPNFEPPRYPYIPAHVTKPKEQTRLFLIQLPEKTLFAVPSNYKLVAAPLFELFDNARAYGPIISSLPQVLSRFNFAYND,negative +GGGAGAAUUCAACUGCCAUCUAUAGAAGAUGAUGCCUGGAUACAAUACAGCCACUCCUCGACUGUAAACCGAGUCCAGAAGCUUGUAGU,MTPDIQAPFLSLLLLFPVLTVANVPTLTTSDSINPRRTTPVSTTQSSPTSSPTKETSWSTTTTLLTASSPAPSPAASPGHDGASTPTSSPAPSPAASPGHDGASTPTSSPAPSPAASPGHDGASTPTSSPAPSPAASPGHDGASTPTSSPAPSPAASPGHNGTSSPTGSPAPSPAASPGHDGASTPTSSPAPSPAASPGHNGTSSPTGSPAPSPAASPGHDGASTPTSSPAPSPAASPGHNGTSSPTGSPAPSPTASPGHDSAPSLTSSPAPSPTASPGQHGASSPTSSDTSSMTTRSMSSSMVTSAHKGTSSRATMTPVSKGTPSSVPSSETAPTAASHITRTAASSPSIALSTSSNPKTSQQLSVRVSLYFLSFRITNLQFNSSLENPQTSYYQELQRSIWGLILQIYKQRDFLGLSEIKFRPGSVVVELTLAFREGTTAEWVKAQFSQLEAHAASYNLTISGVSVYSAPFPSSAQAGSGVPGWGIALLVLVCVLVALAIIYLIALVVCQCGRKKCEQLDVFPTLDAYHPMSEYSTYHTHGRYVPPGSTKRSPYEEVSAGNGGSNLSYTNLAATSANL,negative +AGGAGAAUUAUGAGCGGGACAACUUCGUUCCGUGUUCGCGUACUGAGCGC,MAMQMQLEANADTSVEEESFGPQPISRLEQCGINANDVKKLEEAGFHTVEAVAYAPKKELINIKGISEAKADKILAEAAKLVPMGFTTATEFHQRRSEIIQITTGSKELDKLLQGGIETGSITEMFGEFRTGKTQICHTLAVTCQLPIDRGGGEGKAMYIDTEGTFRPERLLAVAERYGLSGSDVLDNVAYARAFNTDHQTQLLYQASAMMVESRYALLIVDSATALYRTDYSGRGELSARQMHLARFLRMLLRLADEFGVAVVITNQVVAQVDGAAMFAADPKKPIGGNIIAHASTTRLYLRKGRGETRICKIYDSPCLPEAEAMFAINADGVGDAKD,negative +TACTGCATGCACACCACTTCAACTA,MGVLLTQRTLLSLVLALLFPSMASMAAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQGLDVPKLREHCRERPGAFPSEETLRGLGRRGFLQTLNATLGCVLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILGLRNNIYCMAQLLDNSDTAEPTKAGRGASQPPTPTPASDAFQRKLEGCRFLHGYHRFMHSVGRVFSKWGESPNRSRRHSPHQALRKGVRRTRPSRKGKRLMTRGQLPR,negative +GCAGAGAAAGGGUAAGUAUGAUGUCUACCGGAAUGUGUGGGCUUGGUGCG,MSGGDGRGHNTGAHSTSGNINGGPTGLGVGGGASDGSGWSSENNPWGGGSGSGIHWGGGSGHGNGGGNGNSGGGSGTGGNLSAVAAPVAFGFPALSTPGAGGLAVSISAGALSAAIADIMAALKGPFKFGLWGVALYGVLPSQIAKDDPNMMSKIVTSLPADDITESPVSSLPLDKATVNVNVRVVDDVKDERQNISVVSGVPMSVPVVDAKPTERPGVFTASIPGAPVLNISVNNSTPAVQTLSPGVTNNTDKDVRPAGFTQGGNTRDAVIRFPKDSGHNAVYVSVSDVLSPDQVKQRQDEENRRQQEWDATHPVEAAERNYERARAELNQANEDVARNQERQAKAVQVYNSRKSELDAANKTLADAIAEIKQFNRFAHDPMAGGHRMWQMAGLKAQRAQTDVNNKQAAFDAAAKEKSDADAALSSAMESRKKKEDKKRSAENNLNDEKNKPRKGFKDYGHDYHPAPKTENIKGLGDLKPGIPKTPKQNGGGKRKRWTGDKGRKIYEWDSQHGELEGYRASDGQHLGSFDPKTGNQLKGPDPKRNIKKYL,negative +GTTTCCAAAGCCGGGGGGGTGGGATGGGTT,QSVEESRGGLIKPTDTLTLTCTVSGFSLSSYGEVWDRQAPGNGLEYIGAIGNSGSTYYASWAKSRSTITRNTNLNTVTLKMTSLTAADTATYFCAR,negative +GACAGCACGAAUAAAACCUGCGUAAAUCCGCCCCAUUUGUGUAAGGGUAGUGGG,GSNITRVESETKVVILDSFEPLRAETDDAELSVAAECLKKPPKYPPALPIWARPDYNPPLLDRWKAPDYVPPTVHGCALPPQA,negative +GUAAACCGAAGUACUAGACUUGACCUAACA,VVIRSNNFTDNAKTIIVQLNESIAINCTRPNNNTRKSIHIGPGRAFYTTGDIIGNIRQAHCNLSRTKWENTLKQIAKKLREQFGNKTIVFNH,negative +GGAGGCGCGATGTAGGTATGTGAGGGCGGCGCGGTGGGCG,PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGKISKIGPENPYNTPVFAIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDESFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPXRXKNPEMVIYQYMDDLYVGSDLEIGQHRAKIEELRSHLLSWGFTTPDKKHQKEPPFLWMGYELHPDSWTVQPIELPEKDSWTVNE,negative +GGGGGAGGACGCGTAGTGGGGGGCCCATGGTTGTGTGG,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,negative +CCUCUUGCACCGCCGAGAAUAUAAUUCAAGAGGUCCACAACUAAUUAG,MVKSHIGSWILVLFVAMWSDVGLCKKRPKPGGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGTHGQWNKPSKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGSDYEDRYYRENMHRYPNQVYYRPVDQYSNQNNFVHDCVNITVKEHTVTTTTKGENFTETDIKMMERVVEQMCITQYQRESQAYYQRGASVILFSSPPVILLISFLIFLIVG,negative +UUAUUAUUGUUUAUUUUGUGUUGUGUGUUUGUGUU,MEGMLKGEGPGPLPPLLQQYVELRDQYPDYLLLFQVGDFYECFGEDAERLARALGLVLTHKTSKDFTTPMAGIPLRAFEAYAERLLKMGFRLAVADQVEPAEEAEGLVRREVTQLLTPGTLLQESLLPREANYLAAIATGDGWGLAFLDVSTGEFKGTVLKSKSALYDELFRHRPAEVLLAPELLENGAFLDEFRKRFPVMLSEAPFEPEGEGPLALRRARGALLAYAQRTQGGALSLQPFRFYDPGAFMRLPEATLRALEVFEPLRGQDTLFSVLDETRTAPGRRLLQSWLRHPLLDRGPLEARLDRVEGFVREGALREGVRRLLYRLADLERLATRLELGRASPKDLGALRRSLQILPELRALLGEEVGLPDLSPLKEELEAALVEDPPLKVSEGGLIREGYDPDLDALRAAHREGVAYFLELEERERERTGIPTLKVGYNAVFGYYLEVTRPYYERVPKEYRPVQTLKDRQRYTLPEMKEKEREVYRLEALIRRREEEVFLEVRERAKRQAEALREAARILAELDVYAALAEVAVRYGYVRPRFGDRLQIRAGRHPVVERRTEFVPNDLEMAHELVLITGPNMAGKSTFLRQTALIALLAQVGSFVPAEEAHLPLFDGIYTRIGASDDLAGGKSTFMVEMEEVALILKEATENSLVLLDEVGRGTSSLDGVAIATAVAEALHERRAYTLFATHYFELTALGLPRLKNLHVAAREEAGGLVFYHQVLPGPASKSYGVEVAAMAGLPKEVVARARALLQAMAARREGALDAVLERLLALDPDRLTPLEALRLLQELKALALGAPLDTMKG,negative +CACGGTAGTGCTACCAGATGGTTATGTTACTTCAATTCTG,PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGKISKIGPENPYNTPVFAIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDESFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPXRXKNPEMVIYQYMDDLYVGSDLEIGQHRAKIEELRSHLLSWGFTTPDKKHQKEPPFLWMGYELHPDSWTVQPIELPEKDSWTVNE,negative +GAAUAUCUUCCGAAGCCGAACGGGAAAACCGGCAUCU,MKPGGNTIVIWMYAVATWLCFGSTSGWSFTLEDNNIFPKQYPIINFTTAGATVQSYTNFIRAVRGRLTTGADVRHEIPVLPNRVGLPINQRFILVELSNHAELSVTLALDVTNAYVVGYRAGNSAYFFHPDNQEDAEAITHLFTDVQNRYTFAFGGNYDRLEQLAGNLRENIELGNGPLEEAISALYYYSTGGTQLPTLARSFIICIQMISEAARFQYIEGEMRTRIRYNRRSAPDPSVITLENSWGRLSTAIQESNQGAFASPIQLQRRNGSKFSVYDVSILIPIIALMVYRCAPPPSSQFSLLIRPVVPNFNADVCMDPEPIVRIVGRNGLCVDVRDGRFHNGNAIQLWPCKSNTDANQLWTLKRDNTIRSNGKCLTTYGYSPGVYVMIYDCNTAATDATRWQIWDNGTIINPRSSLVLAATSGNSGTTLTVQTNIYAVSQGWLPTNNTQPFVTTIVGLYGLCLQANSGQVWIEDCSSEKAEQQWALYADGSIRPQQNRDNCLTSDSNIRETVVKILSCGPASSGQRWMFKNDGTILNLYSGLVLDVRASDPSLKQIILYPLHGDPNQIWLPLF,negative +GCAAUGGUACGGUACUUCCAAGUGCGGGGGGGAGGUGGUGGUUCCAAAAGUGCACGCUACUUUGCUAA,PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGKISKIGPENPYNTPVFAIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDESFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPXRXKNPEMVIYQYMDDLYVGSDLEIGQHRAKIEELRSHLLSWGFTTPDKKHQKEPPFLWMGYELHPDSWTVQPIELPEKDSWTVNE,negative +CTCCTCTGACTGTAACCACGCCCATATCGGTGAATGCACGAGCAACCGATTGACACGGGGCATAGGTAGTCCAGAAGCC,IMEIRTVAVGIVAIKGVESEYYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHSGGEMFVALNQKGLPVKGKKTKKEQKTAHFLPMAIT,negative +GGGAGACAAGAATAAACGCTCAACAGAGAAGAAGCACCGATGCAACGCGAAAAGCACACGGCCTTCGACAGGAGGCTCACAACAGGC,MSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA,negative +AATCCCAATGGATTGAACTGCCAACGAACG,MPSKKNGRSGPQPHKRWVFTLNNPSEDERKKIRELPISLFDYFIVGEEGNEEGRTPHLQGFANFVKKQTFNKVKWYLGARCHIEKAKGTDQQNKEYCSKEGNLLMECGAPRSQGQRSDLSTAVSTLLESGSLVTVAEQHPVTFVRNFRGLAELLKVSGKMQKRDWKTNVHVIVGPPGCGKSKWAANFADPETTYWKPPRNKWWDGYHGEEVVVIDDFYGWLPWDDLLRLCDRYPLTVETKGGTVPFLARSILITSNQTPLEWYSSAAVPAVEALYRRITSLVFWKNATEQSTEEGGQFVTLSPPCPEFPYEINY,negative +TATTAGCAATAATATTAGCAATAA,MKRASAGGSRLLAWVLWLQAWQVAAPCPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDNPWVCDCRARPLWAWLQKFRGSSSEVPCSLPQRLAGRDLKRLAANDLQGCAVATGPYHPIWTGRATDEEPLGLPKCCQPDAADKASVLEPGRPASAGNALKGRVPPGDSPPGNGSGPRHINDSPFGTLPGSAEPPLTAVRPEGSEPPGFPTSGPRRRPGCSRKNRTRSHCRLGQAGSGGGGTGDSEGSGALPSLTCSLTPLGLALVLWTVLGPC,negative +UAUAUAUGUGUGUCUAUCGUCACUUGUAUGUCAAAUAUU,MLDLFADAEPWQEPLAAGAVILRRFAFNAAEQLIRDINDVASQSPFRQMVTPGGYTMSVAMTNCGHLGWTTHRQGYLYSPIDPQTNKPWPAMPQSFHNLCQRAATAAGYPDFQPDACLINRYAPGAKLSLHQDKDEPDLRAPIVSVSLGLPAIFQFGGLKRNDPLKRLLLEHGDVVVWGGESRLFYHGIQPLKAGFHPLTIDCRYNLTFRQAGKKE,negative +AAGCTCTTAGTTGATGCGCGGTCAAAATTTAAGCT,MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC,negative +TCAAAAGGGGTGATTGCTTGCACAATGACAGGGTAGGACA,IMEIRTVAVGIVAIKGVESEYYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHSGGEMFVALNQKGLPVKGKKTKKEQKTAHFLPMAIT,negative +GGTTGGTTTGGTTGG,MLNQLDNLTERVRGSNKLVDRWLHVRKHLLVAYYNLVGIKPGKESYMRLNEKALDDFCQSLVDYLSAGHFSIYERILHKLEGNGQLARAAKIWPQLEANTQQIMDYYDSSLETAIDHDNYLEFQQVLSDIGEALEARFVLEDKLILLVLDAARVKHPA,negative +CGCCGTATTAAGATTGGGAGACCTGGTAGA,RRIKRLEQEKLELSRKLQESTQTVQALQYSTVDGPLTASKDLEIKNLKEEIEKLRKQVTESSHLEQQLEEANAVRQELDDAFRQIKAYEKQIKTLQQEREDLNKELVQASERLKNQSKELKDAHCQRKLAMQEFMEINER,negative +CCAGAAGAAGCCCACTAGCGTGCTTTTGTC,MNRPHSCLSFCWMYFAASGIRAVETANGKYAQKLFSDLFEDYSSALRPVEDTDAVLNVTLQVTLSQIKDMDERNQILTAYLWIRQTWHDAYLTWDRDQYDRLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDSPAITKSSCVVDVTYFPFDSQQCNLTFGSWTYNGNQVDIFNALDSGDLSDFIEDVEWEVHGMPAVKNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGEKVSLGVTILLAMTVFQLMVAEIMPASENVPLIGKYYIATMALITASTALTIMVMNIHFCGAEARPVPHWAKVVILKYMSRILFVYDVGESCLSPRHSQEPEQVTKVYSKLPESNLKTSRNKDLSRKKEVRKLLKNDLGYQGGIPQNTDSYCARYEALTKNIEYIAKCLKDHKATNSKGSEWKKVAKVIDRFFMWIFFAMVFVMTVLIIARAD,negative +GCCAGGGUUCAUCAUUCACGGCCGAUUUCGAAGCUCCUAACUCGAGACAC,MSAPASTTQATGSTTSTTTKTAGATPATASGLFTIPDGDFFSTARAVVASDAVATNEDLSEIEAVWKDMKVPTDTMAQAAWDLVRHCADVGSSAQTEMIDTGPYSNGISRARLAAAIKEVCTLRQFCMKYAPVVWNWMLTNNSPPANWQAQGFKPEHKFAAFDFFNGVTNPAAIMPKEGLIRPPSEAEMNAAQTAAFVKITKARAQSNDFASLDAAVTRGRITGTTTAEAVVTLPPP,negative +GGTGATCATGGCAGTGTACGCGGGCGGACA,MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICEVEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASSIVYKKEGEQVEFSFPLAFTVEKLTGSGELWWQAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLPQALPQYAGSGNLTLALEAKTGKLHQEVNLVVMRATQLQKNLTCEVWGPTSPKLMLSLKLENKEAKVSKREKAVWVLNPEAGMWQCLLSDSGQVLLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQAERMSQIKRLLSEKKTCQCPHRFQKTCSPI,negative +TCCCACGCATTCTCCACATCCGCACGAGCATCGTACTTCCGTTATGATCATGAGACACAGCCTTTCTGTCCTTCCGTCAC,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +CAACGTGTGATATGTGGGTATACGCTTGGGTGTTACGCTGAGCACAGAGGGTATTCGTGT,MLDLFADAEPWQEPLAAGAVILRRFAFNAAEQLIRDINDVASQSPFRQMVTPGGYTMSVAMTNCGHLGWTTHRQGYLYSPIDPQTNKPWPAMPQSFHNLCQRAATAAGYPDFQPDACLINRYAPGAKLSLHQDKDEPDLRAPIVSVSLGLPAIFQFGGLKRNDPLKRLLLEHGDVVVWGGESRLFYHGIQPLKAGFHPLTIDCRYNLTFRQAGKKE,negative +CCGACCTCCATGGAAACATTCTGCGACTACTTACTGGCC,MLSWGYFLFLLPTLPGAQSQVQLVESGGDVRKPGDSLRLSCKGSGFTFSNYWLGWVRQAPGKALNGSLPLTPLAAAPTYIPGVSGRFTISRDNARALLHLDMSDLRPEDTGRYHCER,negative +AAUAGCAAAAAAAAACAUGAAGUGCAACGC,MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA,negative +GGGAUAUCCUCGAGCAUAAGAAACAAGAUAGAUCCUGAAACUGUUUUAAGGUUGGCCGAUCUUCUGCUCGAGAAUGCAUGAAGCGUUCCAUAUUUUU,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +CCAAGGGCUAAGUCCGCAAAUAUCCUUCCUAAAGGACUCGUUACGUCGG,MSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEMLDRHHTHFCPLEGESWQDFLRNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAFLCQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERETPTTDSMPPLLRQAIELFDHQGAEPAFLFGLELIICGLEKQLKCESGS,negative +GGGAGCTCAGAATAAACGCTCAAAATGCGGGGTGGGTGGGGTGGTTGAAGAATATTCGACATGAGGCCCGGATC,MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM,negative +GUCAGCUGCUCGCGGGAUCGAUCCAUUCGGUGGCCAUGCUCCGGAAGACGGGCCGGCUUCGCAAGACUCAGG,IMEIRTVAVGIVAIKGVESEYYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHSGGEMFVALNQKGLPVKGKKTKKEQKTAHFLPMAIT,negative +GCGAGCAUCAGCCGC,MRKIVVAAIAVSLTTVSITASASADPSKDSKAQVSAAEAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKVKPSAASIDAAKKAGVNNGNPLDAVQQ,negative +ACUGUCCUCCCUUCAGAGAGCGCGGGACCCUUAACUUGGGGCCCACGAACAGCUUCAGUUCCGUCUCGGCGU,ASFTCLAIWALASAGVVPLVLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAAFFFVPVIISTVCYVSIIRCLSSSAVANRSKK,negative +UCUACCAGAGCGAGUGUGCUGAACGUUCUAAGGACGGGAUUGAAUCGAGAUGCGUAUACUAGGACCUUAGG,VVIRSNNFTDNAKTIIVQLNESIAINCTRPNNNTRKSIHIGPGRAFYTTGDIIGNIRQAHCNLSRTKWENTLKQIAKKLREQFGNKTIVFNH,negative +AGCACUUCAGAUAUGAUAACAGGUUCAAGGAUGUGCACA,IMEIRTVAVGIVAIKGVESEYYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHSGGEMFVALNQKGLPVKGKKTKKEQKTAHFLPMAIT,negative +GGGAGGACGATGCGGGCGAAGGCACACCGAGTTCATAGTATCCCACAGACGACGAGCGGGA,MHGDTPTLHEYMLDLQPETTDLYCYEQLNDSSEEEDEIDGPAGQAEPDRAHYNIVTFCCKCDSTLRLCVQSTHVDIRTLEDLLMGTLGIVCPICSQKP,negative +CAGCTCAGAAGCTTGATCCTGTGCGGGCGGCAAGGCCCTGACAGAGATACTGGCTCGGGACTCGAAGTCGTGCATCTGCA,MASTSRLDALPRVTCPNHPDAILVEDYRAGDMICPECDRVIDVGSEWRTFSNDKATKDPSRVGDSQNPLLSDGDLSTMIGKGTGAASFDEFGNSKYQNRRTMSSSDRAMMNAFKEITTMADRINLPRNIVDRTNNLFKQVYEQKSLKGRANDAIASACLYIACRQEGVPRTFKEICAVSRISKKEIGRCFKLILKALETSVDLITTGDFMSRFCSNLCLPKQVQMAATHIA,negative +AGCAGCACAGAGGTCAGATGCGCGCAGAATTTTGAGTCATGTACTAAGGAATTGATTGGTCCTATGCGTGCTACCGTGAA,MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP,negative +CGGAATTCCGAGCGTGGGCGTGGTCATACCGCGCCTATCGAACTCGCCACTCGCGTGCAGCTCTGTGTAGGTACGCCCACGCTCGAG,MKKTLIALAIAASAASGMAHAWMTGDFNGSVDIGGSITADDYRQKWEWKVGTGLNGFGNVLNDLTNGGTKLTITVTGNKPILLGRTKEAFATPVTGGVDGIPHIAFTDYEGASVVLRNPDGETNKKGLAYFVLPMKNAEGTKVGSVKVNASYAGVLGRGGVTSADGELLSLFADGLSSIFYGGLPRGSELSAGSAAAARTKLFGSLSRNDILGQIQRVNANITSLVDVAGSYRENMEYTDGTVVSAAYALGIANGQTIEATFNQAVTTSTQWSAPLNVAITYY,negative +GGGCCGTTCGAACCGAGCATGGATCGAGGATGGGAACACCCAGTAGGAGGATGGGCATGGCCGGACCCAAAATTAGCAGTGGGACAGTACTCAGGTCATCCTAGG,MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC,negative +ACAAAGCUGGAGUACUUACCGAACAUCCGUCUAACCCCU,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +TATTAATAATAATATTAATAATAA,MSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEMLDRHHTHFCPLEGESWQDFLRNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAFLCQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERETPTTDSMPPLLRQAIELFDHQGAEPAFLFGLELIICGLEKQLKCESGS,negative +AGGACUGAAAUAUUCACGUUGACGUUGUCUUGGAGUGCUGAUCGGAAAACCAAUAUGAUUAAGGGUCCUG,MEGMLKGEGPGPLPPLLQQYVELRDQYPDYLLLFQVGDFYECFGEDAERLARALGLVLTHKTSKDFTTPMAGIPLRAFEAYAERLLKMGFRLAVADQVEPAEEAEGLVRREVTQLLTPGTLLQESLLPREANYLAAIATGDGWGLAFLDVSTGEFKGTVLKSKSALYDELFRHRPAEVLLAPELLENGAFLDEFRKRFPVMLSEAPFEPEGEGPLALRRARGALLAYAQRTQGGALSLQPFRFYDPGAFMRLPEATLRALEVFEPLRGQDTLFSVLDETRTAPGRRLLQSWLRHPLLDRGPLEARLDRVEGFVREGALREGVRRLLYRLADLERLATRLELGRASPKDLGALRRSLQILPELRALLGEEVGLPDLSPLKEELEAALVEDPPLKVSEGGLIREGYDPDLDALRAAHREGVAYFLELEERERERTGIPTLKVGYNAVFGYYLEVTRPYYERVPKEYRPVQTLKDRQRYTLPEMKEKEREVYRLEALIRRREEEVFLEVRERAKRQAEALREAARILAELDVYAALAEVAVRYGYVRPRFGDRLQIRAGRHPVVERRTEFVPNDLEMAHELVLITGPNMAGKSTFLRQTALIALLAQVGSFVPAEEAHLPLFDGIYTRIGASDDLAGGKSTFMVEMEEVALILKEATENSLVLLDEVGRGTSSLDGVAIATAVAEALHERRAYTLFATHYFELTALGLPRLKNLHVAAREEAGGLVFYHQVLPGPASKSYGVEVAAMAGLPKEVVARARALLQAMAARREGALDAVLERLLALDPDRLTPLEALRLLQELKALALGAPLDTMKG,negative +GGGAGCTCAGAATAAACGCTCAATCGGTGGGCGGGTGGGGTGGTTGCAGAATGAATTCGACATGAGGCCCGGATC,MQRTKEAVKASDGNLLGDPGRIPLSKRESIKWQRPRFTRQALMRCCLIKWILSSAAPQGSDSSDSELELSTVRHQPEGLDQLQAQTKFTKKELQSLYRGFKNECPTGLVDEDTFKLIYSQFFPQGDATTYAHFLFNAFDADGNGAIHFEDFVVGLSILLRGTVHEKLKWAFNLYDINKDGCITKEEMLAIMKSIYDMMGRHTYPILREDAPLEHVERFFQKMDRNQDGVVTIDEFLETCQKDENIMNSMQLFENVI,negative +TCCCACGCATTCTCCACATCTAGTCTGGTTACGGTCTCGATTGTCCCAAAAGGGCAGACACCTTTCTGTCCTTCCGTCAC,LQENFLPQPRQQHHGTLVLHYRPHREEAGMQHPCLWPGSSHCSDDSTLRRLQCESVTSIGAVCP,negative +UAAGCUCUUUGGCUUAGCCCGACACGUUGAACUCCAGAGU,MAGRSGDSDEELLKAVRLIKFLYQSNPPPNPEGTRQARRNRRRRWRERQRQIHSISERILSTYLGRSAEPVPLQLPPLERLTLDCNEDCGTSGTQGVGSPQILVESPTILESGAKE,negative +GGGUUACCUAGGUGUAGAUGCUCUUCAGAUUCAUUUAUAAGAUCCGACAACCUGUCUAUUAGUUGCGCCGAUUAAGUGACGUCUGAACUGCUUCGAA,QELLCAASLISDRWVLTAAHCLLYPPWDKNFTVNDILVRIGKYARSRYERNMEKISTLEKIIIHPGYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDKQIVTSLLQAGHKGRVTGWGNLKEMWTVNMNEVQPSVLQMVNLPLVERPICKASTGIRVTDNMFCAGYKPEEGKRGDACEGDSGGPFVMKNPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIRKMVDRFG,negative +CTTCTGCCCGCCTCCTTCCGTTTTCCTGCGGCAGCGTTTTGTTGCTTTCGTTCCTCCGGGAGACGAGATAGGCGGACACT,MKKRKVLIPLMALSTILVSSTGNLEVIQAEVKQENRLLNESESSSQGLLGYYFSDLNFQAPMVVTSSTTGDLSIPSSELENIPSENQYFQSAIWSGFIKVKKSDEYTFATSADNHVTMWVDDQEVINKASNSNKIRLEKGRLYQIKIQYQRENPTEKGLDFKLYWTDSQNKKEVISSDNLQLPELKQKSSNSRKKRSTSAGPTVPDRDNDGIPDSLEVEGYTVDVKNKRTFLSPWISNIHEKKGLTKYKSSPEKWSTASDPYSDFEKVTGRIDKNVSPEARHPLVAAYPIVHVDMENIILSKNEDQSTQNTDSQTRTISKNTSTSRTHTSEVHGNAEVHASFFDIGGSVSAGFSNSNSSTVAIDHSLSLAGERTWAETMGLNTADTARLNANIRYVNTGTAPIYNVLPTTSLVLGKNQTLATIKAKENQLSQILAPNNYYPSKNLAPIALNAQDDFSSTPITMNYNQFLELEKTKQLRLDTDQVYGNIATYNFENGRVRVDTGSNWSEVLPQIQETTARIIFNGKDLNLVERRIAAVNPSDPLETTKPDMTLKEALKIAFGFNEPNGNLQYQGKDITEFDFNFDQQTSQNIKNQLAELNATNIYTVLDKIKLNAKMNILIRDKRFHYDRNNIAVGADESVVKEAHREVINSSTEGLLLNIDKDIRKILSGYIVEIEDTEGLKEVINDRYDMLNISSLRQDGKTFIDFKKYNDKLPLYISNPNYKVNVYAVTKENTIINPSENGDTSTNGIKKILIFSKKGYEIG,negative +CTTTGGAGACAGTCCGTGGTAGGGCAGGTTGGGGTGACTTCGTGGAAGAAGCGAGACGGT,MAGRSGDSDEELLKAVRLIKFLYQSNPPPNPEGTRQARRNRRRRWRERQRQIHSISERILSTYLGRSAEPVPLQLPPLERLTLDCNEDCGTSGTQGVGSPQILVESPTILESGAKE,negative +UAAACCUGCUGGCAGUGUGACCUAAGGACCAAGCCGUUCCUGAGGAACGUC,MAKGEFIRTKPHVNVGTIGHVDHGKTTLTAALTYVAAAENPNVEVKDYGDIDKAPEERARGITINTAHVEYETAKRHYSHVDCPGHADYIKNMITGAAQMDGAILVVSAADGPMPQTREHILLARQVGVPYIVVFMNKVDMVDDPELLDLVEMEVRDLLNQYEFPGDEVPVIRGSALLALEEMHKNPKTKRGENEWVDKIWELLDAIDEYIPTPVRDVDKPFLMPVEDVFTITGRGTVATGRIERGKVKVGDEVEIVGLAPETRKTVVTGVEMHRKTLQEGIAGDNVGLLLRGVSREEVERGQVLAKPGSITPHTKFEASVYILKKEEGGRHTGFFTGYRPQFYFRTTDVTGVVRLPQGVEMVMPGDNVTFTVELIKPVALEEGLRFAIREGGRTVGAGVVTKILE,negative +UAUCCUCGCCCGUGCACGCCCUCCACUAAGCCCA,MAWYWWRRRRRRGWWKPRRRRWRRRRARRRGPARRHRARRRIVRHPCNGQTSSGNRVPRSVQAVDPKYVSLQLVWHSWDFRRGLFGQAGIKRMQQESDALTLSPVHRPKRPKRDTQVKEKTPEKDSDSAVQLRRLQPWIHSSQETKDEEEEIPEGPVQEQLLQQLQQQRLLRVQLESIAQEVLKIRRGHSLHPLLSSHA,negative +ACCGAAAAAGACCUGACUUCUAUACUAAGUCUACGUUCC,MVKSHIGSWILVLFVAMWSDVGLCKKRPKPGGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGSHSQWNKPSKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGNDYEDRYYRENMYRYPNQVYYRPVDRYSNQNNFVHDCVNITVKQHTVTTTTKGENFTETDIKIMERVVEQMCITQYQRESQAYYQRGASVILFSSPPVILLISFLIFLIVG,negative +GGGAAUGGAUCCACAUCUACGAAUUCAGGGGACGUAGCAAUGACUGAGAUGCUGGGUUCACUGCAGACUUGACGAAGCUU,MAWYWWRRRRRRGWWKPRRRRWRRRRARRRGPARRHRARRRIVRHPCNGQTSSGNRVPRSVQAVDPKYVSLQLVWHSWDFRRGLFGQAGIKRMQQESDALTLSPVHRPKRPKRDTQVKEKTPEKDSDSAVQLRRLQPWIHSSQETKDEEEEIPEGPVQEQLLQQLQQQRLLRVQLESIAQEVLKIRRGHSLHPLLSSHA,negative +GCAUGCAGUGUCUAUUCUCGAGUAGCGAUCGUUGAAGGGGUAUAAGGUUGGCAGAUCGCUAGCAUGCAACUGACUCGGAUAAGCA,MASTSRLDALPRVTCPNHPDAILVEDYRAGDMICPECDRVIDVGSEWRTFSNDKATKDPSRVGDSQNPLLSDGDLSTMIGKGTGAASFDEFGNSKYQNRRTMSSSDRAMMNAFKEITTMADRINLPRNIVDRTNNLFKQVYEQKSLKGRANDAIASACLYIACRQEGVPRTFKEICAVSRISKKEIGRCFKLILKALETSVDLITTGDFMSRFCSNLCLPKQVQMAATHIA,negative +AGTAATACGACTCACTATAGGGAGAATTCCGACCAGAAGGGUUAGCGGUCGUCUUAAGUAGUUUUUGGUCCTTTCCTCTCTCCTTCCTCTTCT,VFTDNSSPPAVPQSFQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGFGAYMSKAHGVDPNIRTGVRTITTGSPITYSTYGKFLADGGCSGGAYDIIICDECHSTDATSILGIGTVLDQAETAGARLVVLATATPPGSVTVSHPNIEEVALSTTGEIPFYGKAIPLEVIKGGRHLIFCHSKKKCDELAAKLVALGINAVAYYRGLDVSVIPTSGDVVVVSTDALMTGFTGDFDSVIDCNTCVTQTVDFSLDPTFTIETTTLPQDAVSRTQRRGRTGRGKPGIYRFVAPGERPSGMFDSSVLCECYDAGCAWYELTPAETTVRLRAYMNTPGLPVCQDHLEFWEGVFTGLTHIDAHFLSQTKQSGENFPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPTLHGPTPLLYRLGAVQNEVT,negative +UAAUACGACUCACUAUAGGGAGGACGAUGCGGACAUAGUAAUGACACGGAGGAUGGAGAAAAAACAGCCAUCUCUUGACGGUUCGGGCGAGUCGUCUG,MAVAQELYGFPASKLDSFVAQWLQPTREWKEEVLETVQTVEQFLRQENFREDRGPARDVRVLKVLKVGCFGNGTVLRSTTDVELVVFLSCFHSFQEEAKHHQAVLRLIQKRMYYCQELMDLGLSNLSVTNRVPSSLIFTIQTRETWETITVTVVPAYRALGPSCPSSEVYANLIKANGYPGNFSPSFSELQRNFVKHRPTKLKSLLRLVKHWYQQYVRDKCPRANLPPLYALELLTVYAWEAGTREDANFRLDEGLATVMELLQDHELLCIYWTKHYTLQHPVIEACVRRQLRGQRPIILDPADPTNNVAEGYRWDIVAQRANQCLKQDCCYDNRDSPVPSWRVKRAPDIQVTVQEWGHSDLTFWVNPYEPIKKLKEKIQLSQGYLGLQRLSFQEPGGERQLIRSHCTLAYYGIFCDTHICLLDTISPEIQVFVKNPDGRSHAYAIHPLDYVLNLKQQIEDRQGLRCQEQRLEFQGHILEDWFDFKSYGIQDSVTVILSKTTEGAAPFVPS,negative +ACAAAUCCCCAGGAGUGCAAUACUCCGCAA,MKRASAGGSRLLAWVLWLQAWQVAAPCPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDNPWVCDCRARPLWAWLQKFRGSSSEVPCSLPQRLAGRDLKRLAANDLQGCAVATGPYHPIWTGRATDEEPLGLPKCCQPDAADKASVLEPGRPASAGNALKGRVPPGDSPPGNGSGPRHINDSPFGTLPGSAEPPLTAVRPEGSEPPGFPTSGPRRRPGCSRKNRTRSHCRLGQAGSGGGGTGDSEGSGALPSLTCSLTPLGLALVLWTVLGPC,negative +GGACCUUUGUACCCCAGAUGAUAGUGAGGCGCGGCUUGAUGGGUACAAAUGGCAG,MASTSRLDALPRVTCPNHPDAILVEDYRAGDMICPECDRVIDVGSEWRTFSNDKATKDPSRVGDSQNPLLSDGDLSTMIGKGTGAASFDEFGNSKYQNRRTMSSSDRAMMNAFKEITTMADRINLPRNIVDRTNNLFKQVYEQKSLKGRANDAIASACLYIACRQEGVPRTFKEICAVSRISKKEIGRCFKLILKALETSVDLITTGDFMSRFCSNLCLPKQVQMAATHIA,negative +CGGACGAAATTCGTCCCTGTGTG,MVKSHIGSWILVLFVAMWSDVGLCKKRPKPGGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGTHGQWNKPSKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGSDYEDRYYRENMHRYPNQVYYRPVDQYSNQNNFVHDCVNITVKEHTVTTTTKGENFTETDIKMMERVVEQMCITQYQRESQAYYQRGASVILFSSPPVILLISFLIFLIVG,negative +CAUACCAUCCCCAUUUUCGCAAUGAAAAG,MHGDTPTLHEYMLDLQPETTDLYCYEQLNDSSEEEDEIDGPAGQAEPDRAHYNIVTFCCKCDSTLRLCVQSTHVDIRTLEDLLMGTLGIVCPICSQKP,negative +AGUUUCAUCGUCCGAGCAAGAUCCUAAUGGCGUCCGGCGCGUUUAUGACU,QELLCAASLISDRWVLTAAHCLLYPPWDKNFTVNDILVRIGKYARSRYERNMEKISTLEKIIIHPGYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDKQIVTSLLQAGHKGRVTGWGNLKEMWTVNMNEVQPSVLQMVNLPLVERPICKASTGIRVTDNMFCAGYKPEEGKRGDACEGDSGGPFVMKNPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIRKMVDRFG,negative +CTCCTCTGACTGTAACCACGCCGAAGACCTTTTTAGCGTACTGAAAAGGAGTTACTCTCGCATAGGTAGTCCAGAAGCC,MKKRKVLIPLMALSTILVSSTGNLEVIQAEVKQENRLLNESESSSQGLLGYYFSDLNFQAPMVVTSSTTGDLSIPSSELENIPSENQYFQSAIWSGFIKVKKSDEYTFATSADNHVTMWVDDQEVINKASNSNKIRLEKGRLYQIKIQYQRENPTEKGLDFKLYWTDSQNKKEVISSDNLQLPELKQKSSNSRKKRSTSAGPTVPDRDNDGIPDSLEVEGYTVDVKNKRTFLSPWISNIHEKKGLTKYKSSPEKWSTASDPYSDFEKVTGRIDKNVSPEARHPLVAAYPIVHVDMENIILSKNEDQSTQNTDSQTRTISKNTSTSRTHTSEVHGNAEVHASFFDIGGSVSAGFSNSNSSTVAIDHSLSLAGERTWAETMGLNTADTARLNANIRYVNTGTAPIYNVLPTTSLVLGKNQTLATIKAKENQLSQILAPNNYYPSKNLAPIALNAQDDFSSTPITMNYNQFLELEKTKQLRLDTDQVYGNIATYNFENGRVRVDTGSNWSEVLPQIQETTARIIFNGKDLNLVERRIAAVNPSDPLETTKPDMTLKEALKIAFGFNEPNGNLQYQGKDITEFDFNFDQQTSQNIKNQLAELNATNIYTVLDKIKLNAKMNILIRDKRFHYDRNNIAVGADESVVKEAHREVINSSTEGLLLNIDKDIRKILSGYIVEIEDTEGLKEVINDRYDMLNISSLRQDGKTFIDFKKYNDKLPLYISNPNYKVNVYAVTKENTIINPSENGDTSTNGIKKILIFSKKGYEIG,negative +GGTTGGTTTATTTTATTACTAGTGGCCAGG,MAVAQELYGFPASKLDSFVAQWLQPTREWKEEVLETVQTVEQFLRQENFREDRGPARDVRVLKVLKVGCFGNGTVLRSTTDVELVVFLSCFHSFQEEAKHHQAVLRLIQKRMYYCQELMDLGLSNLSVTNRVPSSLIFTIQTRETWETITVTVVPAYRALGPSCPSSEVYANLIKANGYPGNFSPSFSELQRNFVKHRPTKLKSLLRLVKHWYQQYVRDKCPRANLPPLYALELLTVYAWEAGTREDANFRLDEGLATVMELLQDHELLCIYWTKHYTLQHPVIEACVRRQLRGQRPIILDPADPTNNVAEGYRWDIVAQRANQCLKQDCCYDNRDSPVPSWRVKRAPDIQVTVQEWGHSDLTFWVNPYEPIKKLKEKIQLSQGYLGLQRLSFQEPGGERQLIRSHCTLAYYGIFCDTHICLLDTISPEIQVFVKNPDGRSHAYAIHPLDYVLNLKQQIEDRQGLRCQEQRLEFQGHILEDWFDFKSYGIQDSVTVILSKTTEGAAPFVPS,negative +ATTGACCGCTGTGTGACGCAACACTCAAT,MASTSRLDALPRVTCPNHPDAILVEDYRAGDMICPECDRVIDVGSEWRTFSNDKATKDPSRVGDSQNPLLSDGDLSTMIGKGTGAASFDEFGNSKYQNRRTMSSSDRAMMNAFKEITTMADRINLPRNIVDRTNNLFKQVYEQKSLKGRANDAIASACLYIACRQEGVPRTFKEICAVSRISKKEIGRCFKLILKALETSVDLITTGDFMSRFCSNLCLPKQVQMAATHIA,negative +GCUAUCAUCAUUAACUUUAUUUAUUACCGUCAUUCAUUUCUGAAUGUCUGUUUACCCCUAUUUCAACCGGUUUUUUUU,MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINYDEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQAVAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQGIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADMDFSALLSQISS,negative +GAAGTAGCATGAACATATACCCGTTGACTCAATTTTATTTTAGTCCAACA,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,negative +UGUUGUUGGACCAGUGUUAUUUUACGCGAUUGUGCGGUUGUGA,PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGKISKIGPENPYNTPVFAIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDESFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPXRXKNPEMVIYQYMDDLYVGSDLEIGQHRAKIEELRSHLLSWGFTTPDKKHQKEPPFLWMGYELHPDSWTVQPIELPEKDSWTVNE,negative +ACTCGAACATTTCCACTAACCAACCATACTAAAGCACCGC,MSGGDGRGHNTGAHSTSGNINGGPTGLGVGGGASDGSGWSSENNPWGGGSGSGIHWGGGSGHGNGGGNGNSGGGSGTGGNLSAVAAPVAFGFPALSTPGAGGLAVSISAGALSAAIADIMAALKGPFKFGLWGVALYGVLPSQIAKDDPNMMSKIVTSLPADDITESPVSSLPLDKATVNVNVRVVDDVKDERQNISVVSGVPMSVPVVDAKPTERPGVFTASIPGAPVLNISVNNSTPAVQTLSPGVTNNTDKDVRPAGFTQGGNTRDAVIRFPKDSGHNAVYVSVSDVLSPDQVKQRQDEENRRQQEWDATHPVEAAERNYERARAELNQANEDVARNQERQAKAVQVYNSRKSELDAANKTLADAIAEIKQFNRFAHDPMAGGHRMWQMAGLKAQRAQTDVNNKQAAFDAAAKEKSDADAALSSAMESRKKKEDKKRSAENNLNDEKNKPRKGFKDYGHDYHPAPKTENIKGLGDLKPGIPKTPKQNGGGKRKRWTGDKGRKIYEWDSQHGELEGYRASDGQHLGSFDPKTGNQLKGPDPKRNIKKYL,negative +CCAGAAGAAGCCCACTAGCGTGCTTTTGTC,MHGDTPTLHEYMLDLQPETTDLYCYEQLNDSSEEEDEIDGPAGQAEPDRAHYNIVTFCCKCDSTLRLCVQSTHVDIRTLEDLLMGTLGIVCPICSQKP,negative +UCCAAACCCCGUUGAGAGUUGAUCCGGUCUAGGGAAUGGAAAGAAGUAGGUAUCGAAGAGAAUGUACCCU,MGVLLTQRTLLSLVLALLFPSMASMAAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQGLDVPKLREHCRERPGAFPSEETLRGLGRRGFLQTLNATLGCVLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILGLRNNIYCMAQLLDNSDTAEPTKAGRGASQPPTPTPASDAFQRKLEGCRFLHGYHRFMHSVGRVFSKWGESPNRSRRHSPHQALRKGVRRTRPSRKGKRLMTRGQLPR,negative +GAAGCUUACAAGAAGGACAGCACGAAUAAAACCUGCGUAAAUCCGCCCCAUUUGUGUAAGGGUAGUGGGUCGAAUUCCGCUCA,MKEFEVKVASTAFVLVLFSLTINQILASETSTKFRSPVPAPTVPDWNHLPNEGNEENVVSAPKQDGASGGQKPYWTKREKMMKRLHAEPAGNTVRFRCAVDGNPKPQVLWYKNDLIVQKNDRVGGYKYRNQVLILESVVLSDKGNYMCVARNEYGSINHTYQLDVQERSASKPILAEGLPQNKSAYIGDDVTFKCKVYSDAHPHIQWLKSINNHNNAAPNYTVLKAAGVNTTDLDMEVLILKNVSFEEAGEYTCLAGNSIGISHQSAWLSVLPVPPPTTDTITKGIPNETNIIIYVMCGVLVILFGLAVVLVLYYHCYNGKDPPMLVRIENPDNIPPMTKIEHPTMLFGNTQAWQRMCMPMQEPFEFNIQLDLQWELQREDITLVERLDEGFFGQVFKADLVTCNNTRKEKMVCAVKMLKGNRNEKDVLDLLTEMDQMKRVGKHKNIINLLGVCTQNGPLWLVIEYAAQGNLRDYLRRNRPQNTLCNLVLPSEGRNPDDELPVPHGDTLTQKDIVSFAFQVARGLEFLAQKKCIHRDLAARNVLVTEELVMKIADFGLARDIRSCDYYRKHTRGHLPYKWMALEAMSDNIFTHATDVWSFGVLLWEIFSLAGSPYPGIKTHELVKFLRSGERLDKPQYASQEMYRLMRDCWEEDPSKRPNFRTLVEDLDRMLAESSTEVYIDFAAGCEAEYSESSEDESESQNSDEEDDDSVFERMRQIDSLSNGNIPFNEEDSSNSDPYVAPLLQNEENVLQNEHARLRSEA,negative +GCGGAAGGUCCGAAGACCGGCGAAAGGAACGAGAUUGCC,MHGDTPTLHEYMLDLQPETTDLYCYEQLNDSSEEEDEIDGPAGQAEPDRAHYNIVTFCCKCDSTLRLCVQSTHVDIRTLEDLLMGTLGIVCPICSQKP,negative +ACACGGGCCGTGAACGCAGCGAGTTCGCCCGTCGTGACATT,MSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEMLDRHHTHFCPLEGESWQDFLRNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAFLCQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERETPTTDSMPPLLRQAIELFDHQGAEPAFLFGLELIICGLEKQLKCESGS,negative +ACCAAAATCAACGCAAAGAGCGCGCCTGCACGTCACCTCA,GRQVDIDGEDYQRRDSIAQLLEDWGLIVIEDSAREDLFGLTNNFRVISFKQKDDWTLKAKYTIGN,negative +GGACCUUUGUACCCCAGAUGAUGCUUUAUCAGGCGGAUGGGUACAAAUGGCAG,MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC,negative +GGGAGAAGGGAAGTAACAGGCUAGAAGUUUAGACCAAGGGGCGGGAUGAGTGAGAAGAGGTGACGGTACCAG,MAVAQELYGFPASKLDSFVAQWLQPTREWKEEVLETVQTVEQFLRQENFREDRGPARDVRVLKVLKVGCFGNGTVLRSTTDVELVVFLSCFHSFQEEAKHHQAVLRLIQKRMYYCQELMDLGLSNLSVTNRVPSSLIFTIQTRETWETITVTVVPAYRALGPSCPSSEVYANLIKANGYPGNFSPSFSELQRNFVKHRPTKLKSLLRLVKHWYQQYVRDKCPRANLPPLYALELLTVYAWEAGTREDANFRLDEGLATVMELLQDHELLCIYWTKHYTLQHPVIEACVRRQLRGQRPIILDPADPTNNVAEGYRWDIVAQRANQCLKQDCCYDNRDSPVPSWRVKRAPDIQVTVQEWGHSDLTFWVNPYEPIKKLKEKIQLSQGYLGLQRLSFQEPGGERQLIRSHCTLAYYGIFCDTHICLLDTISPEIQVFVKNPDGRSHAYAIHPLDYVLNLKQQIEDRQGLRCQEQRLEFQGHILEDWFDFKSYGIQDSVTVILSKTTEGAAPFVPS,negative +GGAATAGAGACAAAGCCACTCATATGAGT,MDKFWWHAAWGLCLVPLSLAQIDLNITCRFAGVFHVEKNGRYSISRTEAADLCKAFNSTLPTMAQMEKALSIGFETCRYGFIEGHVVIPRIHPNSICAANNTGVYILTSNTSQYDTYCFNASAPPEEDCTSVTDLPNAFDGPITITIVNRDGTRYVQKGEYRTNPEDIYPSNPTDDDVSSGSSSERSSTSGGYIFYTFSTVHPIPDEDSPWITDSTDRIPATTLMSTSATATETATKRQETWDWFSWLFLPSESKNHLHTTTQMAGTSSNTISAGWEPNEENEDERDRHLSFSGSGIDDDEDFISSTISTTPRAFDHTKQNQDWTQWNPSHSNPEVLLQTTTRMTDVDRNGTTAYEGNWNPEAHPPLIHHEHHEEEETPHSTSTIQATPSSTTEETATQKEQWFGNRWHEGYRQTPKEDSHSTTGTAAASAHTSHPMQGRTTPSPEDSSWTDFFNPISHPMGRGHQAGRRMDMDSSHSITLQPTANPNTGLVEDLDRTGPLSMTTQQSNSQSFSTSHEGLEEDKDHPTTSTLTSSNRNDVTGGRRDPNHSEGSTTLLEGYTSHYPHTKESRTFIPVTSAKTGSFGVTAVTVGDSNSNVNRSLSGDQDTFHPSGGSHTTHGSESDGHSHGSQEGGANTTSGPIRTPQIPEWLIILASLLALALILAVCIAVNSRRRCGQKKKLVINSGNGAVEDRKPSGLNGEASKSQEMVHLVNKESSETPDQFMTADETRNLQNVDMKIGV,negative +CATCTCGGTCGTGAACTTTACATGCATGAGTATTTTGGTG,MGVLLTQRTLLSLVLALLFPSMASMAAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQGLDVPKLREHCRERPGAFPSEETLRGLGRRGFLQTLNATLGCVLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILGLRNNIYCMAQLLDNSDTAEPTKAGRGASQPPTPTPASDAFQRKLEGCRFLHGYHRFMHSVGRVFSKWGESPNRSRRHSPHQALRKGVRRTRPSRKGKRLMTRGQLPR,negative +ACAGCGCCGGUGGGCGGGCAUUGGGUGGAUGCGCUGU,MAGRSGDSDEELLKAVRLIKFLYQSNPPPNPEGTRQARRNRRRRWRERQRQIHSISERILSTYLGRSAEPVPLQLPPLERLTLDCNEDCGTSGTQGVGSPQILVESPTILESGAKE,negative +CCCAAUUCCGACCUGCGUCUACGUAACCUGCCAUCG,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,negative +CTTCTGCCCGCCTCCTTCCCGGGTCATATGGGAACGCTACAGTGTTTCACGCTGAGTTGGAGACGAGATAGGCGGACACT,MPFVNKQFNYKDPVNGVDIAYIKIPNVGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAGHRLYGIAINPNRVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNRKTYLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLKNFTGLFEFYKLLCVRGIITSKTKSLDKGYNKALNDLCIKVNNWDLFFSPSEDNFTNDLNKGEEITSDTNIEAAEENISLDLIQQYYLTFNFDNEPENISIENLSSDIIGQLELMPNIERFPNGKKYELDKYTMFHYLRAQEFEHGKSRIALTNSVNEALLNPSRVYTFFSSDYVKKVNKATEAAMFLGWVEQLVYDFTDETSEVSTTDKIADITIIIPYIGPALNIGNMLYKDDFVGALIFSGAVILLEFIPEIAIPVLGTFALVSYIANKVLTVQTIDNALSKRNEKWDEVYKYIVTNWLAKVNTQIDLIRKKMKEALENQAEATKAIINYQYNQYTEEEKNNINFNIDDLSSKLNESINKAMININKFLNQCSVSYLMNSMIPYGVKRLEDFDASLKDALLKYIYDNRGTLIGQVDRLKDKVNNTLSTDIPFQLSKYVDNQRLLSTFTEYIKNIINTSILNLRYESNHLIDLSRYASKINIGSKVNFDPIDKNQIQLFNLESSKIEVILKNAIVYNSMYENFSTSFWIRIPKYFNSISLNNEYTIINCMENNSGWKVSLNYGEIIWTLQDTQEIKQRVVFKYSQMINISDYINRWIFVTITNNRLNNSKIYINGRLIDQKPISNLGNIHASNNIMFKLDGCRDTHRYIWIKYFNLFDKELNEKEIKDLYDNQSNSGILKDFWGDYLQYDKPYYMLNLYDPNKYVDVNNVGIRGYMYLKGPRGSVMTTNIYLNSSLYRGTKFIIKKYASGNKDNIVRNNDRVYINVVVKNKEYRLATNASQAGVEKILSALEIPDVGNLSQVVVMKSKNDQGITNKCKMNLQDNNGNDIGFIGFHQFNNIAKLVASNWYNRQIERSSRTLGCSWEFIPVDDGWGERPL,negative +CTTCTGCCCGCCTCCTTCCAGCCGTCACAGGTCGCTCATTCATTACGGTCTGTTTGCGGGAGACGAGATAGGCGGACACT,MAPFLRIAFNSYELGSLQAEDEANQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKSTFDAHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNGKAEFWLDLQPQAKVLMSVQYFLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQVTQRASRRSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTYGKIWEGSSKCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGVTGNIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKNLIDSMDQSAFAGFSFVNPKFEHLLED,negative +UCGUGU,QELLCAASLISDRWVLTAAHCLLYPPWDKNFTVNDILVRIGKYARSRYERNMEKISTLEKIIIHPGYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDKQIVTSLLQAGHKGRVTGWGNLKEMWTVNMNEVQPSVLQMVNLPLVERPICKASTGIRVTDNMFCAGYKPEEGKRGDACEGDSGGPFVMKNPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIRKMVDRFG,negative +GGGAGGACGAUGCGGACCGAAAAAGACCUGACUUCUAUACUAAGUCUACGUUCCCAGACGACUCGCCCGA,VFTDNSSPPAVPQSFQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGFGAYMSKAHGVDPNIRTGVRTITTGSPITYSTYGKFLADGGCSGGAYDIIICDECHSTDATSILGIGTVLDQAETAGARLVVLATATPPGSVTVSHPNIEEVALSTTGEIPFYGKAIPLEVIKGGRHLIFCHSKKKCDELAAKLVALGINAVAYYRGLDVSVIPTSGDVVVVSTDALMTGFTGDFDSVIDCNTCVTQTVDFSLDPTFTIETTTLPQDAVSRTQRRGRTGRGKPGIYRFVAPGERPSGMFDSSVLCECYDAGCAWYELTPAETTVRLRAYMNTPGLPVCQDHLEFWEGVFTGLTHIDAHFLSQTKQSGENFPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPTLHGPTPLLYRLGAVQNEVT,negative +CCCGUACCACCACACCCUAUGCACAUCGUUGUUUGUCGUCUUUCCCGCAU,MLNQLDNLTERVRGSNKLVDRWLHVRKHLLVAYYNLVGIKPGKESYMRLNEKALDDFCQSLVDYLSAGHFSIYERILHKLEGNGQLARAAKIWPQLEANTQQIMDYYDSSLETAIDHDNYLEFQQVLSDIGEALEARFVLEDKLILLVLDAARVKHPA,negative +GGTTGGTGTGGTTGG,MAWYWWRRRRRRGWWKPRRRRWRRRRARRRGPARRHRARRRIVRHPCNGQTSSGNRVPRSVQAVDPKYVSLQLVWHSWDFRRGLFGQAGIKRMQQESDALTLSPVHRPKRPKRDTQVKEKTPEKDSDSAVQLRRLQPWIHSSQETKDEEEEIPEGPVQEQLLQQLQQQRLLRVQLESIAQEVLKIRRGHSLHPLLSSHA,negative +GGGUUCGCUAAGUUGGUCUACCCCUCUCGAAUAUCCGUUA,MLPWTALGLALSLRLALARSGAERGPPASAPRGDLMFLLDSSASVSHYEFSRVREFVGQLVAPLPLGTGALRASLVHVGSRPYTEFPFGQHSSGEAAQDAVRASAQRMGDTHTGLALVYAKEQLFAEASGARPGVPKVLVWVTDGGSSDPVGPPMQELKDLGVTVFIVSTGRGNFLELSAAASAPAEKHLHFVDVDDLHIIVQELRGSILDAMRPQQLHATEITSSGFRLAWPPLLTADSGYYVLELVPSAQPGAARRQQLPGNATDWIWAGLDPDTDYDVALVPESNVRLLRPQILRVRTRPGEAGPGASGPESGAGPAPTQLAALPAPEEAGPERIVISHARPRSLRVSWAPALGSAAALGYHVQFGPLRGGEAQRVEVPAGRNCTTLQGLAPGTAYLVTVTAAFRSGRESALSAKACTPDGPRPRPRPVPRAPTPGTASREP,negative +TTTCTAGGAAATTCAAACAGGTTTGTATTTTTCTAGTTGA,PHITDVVLDKANKTPLRQLDPSRLPDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFAKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRQSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPINRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDTASEATRPATLNRFSALQQTLPAENTDNRRVVQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRTRTPATKRSFSKEVEERSRERPSQPEGLRKAASLTEDRGRDPVKREATLPPVSPPKAALSVDEVEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRLGIESTLERSTIAREHMGRLLHQLLCAGHLSTAQYYQGLYETLELAEDMEIDIPHVWLYLAELITPILQEDGVPMGELFREITKPLRPMGKATSLLLEILGLLCKSMGPKKVGMLWREAGLSWREFLAEGQDVGSFVAEKKVEYTLGEESEAPGQRTLAFEELRRQLEKLLKDGGSNQRVFDWIDANLNEQQIASNTLVRALMTTVCYSAIIFETPLRVDVQVLKVRARLLQKYLCDEQKELQALYALQALVVTLEQPANLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFNWLREAEDEESDHN,negative +GGUAGAUACGAUGGAUCAGGGUACCCCCUGUGGCCCGUCAACACAGGGGAAGUGGCAUGACGCGCAGCCA,MKKRKVLIPLMALSTILVSSTGNLEVIQAEVKQENRLLNESESSSQGLLGYYFSDLNFQAPMVVTSSTTGDLSIPSSELENIPSENQYFQSAIWSGFIKVKKSDEYTFATSADNHVTMWVDDQEVINKASNSNKIRLEKGRLYQIKIQYQRENPTEKGLDFKLYWTDSQNKKEVISSDNLQLPELKQKSSNSRKKRSTSAGPTVPDRDNDGIPDSLEVEGYTVDVKNKRTFLSPWISNIHEKKGLTKYKSSPEKWSTASDPYSDFEKVTGRIDKNVSPEARHPLVAAYPIVHVDMENIILSKNEDQSTQNTDSQTRTISKNTSTSRTHTSEVHGNAEVHASFFDIGGSVSAGFSNSNSSTVAIDHSLSLAGERTWAETMGLNTADTARLNANIRYVNTGTAPIYNVLPTTSLVLGKNQTLATIKAKENQLSQILAPNNYYPSKNLAPIALNAQDDFSSTPITMNYNQFLELEKTKQLRLDTDQVYGNIATYNFENGRVRVDTGSNWSEVLPQIQETTARIIFNGKDLNLVERRIAAVNPSDPLETTKPDMTLKEALKIAFGFNEPNGNLQYQGKDITEFDFNFDQQTSQNIKNQLAELNATNIYTVLDKIKLNAKMNILIRDKRFHYDRNNIAVGADESVVKEAHREVINSSTEGLLLNIDKDIRKILSGYIVEIEDTEGLKEVINDRYDMLNISSLRQDGKTFIDFKKYNDKLPLYISNPNYKVNVYAVTKENTIINPSENGDTSTNGIKKILIFSKKGYEIG,negative +GGGACACAAUGGACGUCCGUAGUUCUGGCUGACUGGUUACCCGGUCGUACAGCUCUAACGGCCGACAUGAGAG,MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNLERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCPFGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGRVSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVFHKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVEGTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT,negative +AGGGAATCTTGCCTAGGGAGGGAGTAGCGAAAGGGCTCA,MKPGGNTIVIWMYAVATWLCFGSTSGWSFTLEDNNIFPKQYPIINFTTAGATVQSYTNFIRAVRGRLTTGADVRHEIPVLPNRVGLPINQRFILVELSNHAELSVTLALDVTNAYVVGYRAGNSAYFFHPDNQEDAEAITHLFTDVQNRYTFAFGGNYDRLEQLAGNLRENIELGNGPLEEAISALYYYSTGGTQLPTLARSFIICIQMISEAARFQYIEGEMRTRIRYNRRSAPDPSVITLENSWGRLSTAIQESNQGAFASPIQLQRRNGSKFSVYDVSILIPIIALMVYRCAPPPSSQFSLLIRPVVPNFNADVCMDPEPIVRIVGRNGLCVDVRDGRFHNGNAIQLWPCKSNTDANQLWTLKRDNTIRSNGKCLTTYGYSPGVYVMIYDCNTAATDATRWQIWDNGTIINPRSSLVLAATSGNSGTTLTVQTNIYAVSQGWLPTNNTQPFVTTIVGLYGLCLQANSGQVWIEDCSSEKAEQQWALYADGSIRPQQNRDNCLTSDSNIRETVVKILSCGPASSGQRWMFKNDGTILNLYSGLVLDVRASDPSLKQIILYPLHGDPNQIWLPLF,negative +GGTTGGTGTGGTTGG,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,negative +GTCAAGNACGCGAACCCCGCATTCCCAAGAACGGCAACCCT,MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINYDEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQAVAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQGIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADMDFSALLSQISS,negative +GCGCAGAACGGTGCTGTAACGGTGTGGC,MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA,negative +CCCAGCGGACGCCTCATGCCGAGTAGCC,MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPGPHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR,negative +UCGGACCGGCAAUAAGGGUAUGGCCGUAUAAUCCAGGUCGCCGCUGUCCGA,QSVEESRGGLIKPTDTLTLTCTVSGFSLSSYGEVWDRQAPGNGLEYIGAIGNSGSTYYASWAKSRSTITRNTNLNTVTLKMTSLTAADTATYFCAR,negative +CAGUCGUCAUGGUUAUAGCUGCCACAACCUCGGUCCUGUCUUCAACGGCC,MIPPPRRSASSTPKDYRSSRDLQPWRGVSSGDAAETSQQSRHRRDAIADGGGRLKGAAQSSPSSGTRRSGPYAQGRAMPKNENIPKPGKQRLGPRKKKLSTLKKKILLDRLERWRDKQHEGALSTPSATASSEEAKCNNPFPLCPPGELSPPPSPPATICPAVVDKSTSYGQVGGANGERSVWAITIYNLVDQEDVEDDDDHAEIERDLWDMSSAFGVVRSVQVPRGTAVQVSDAEVSAAAAAGEPAAVAAKVAFATNAEAECARDGLNGRIVGGKPLLVRIHRCDGHFCGGVCPGDPDGSGLWRVAIENLIDEEDDLDDEDEYAEISANVSAMMGCYGKLVDVQVRRSSPSKGEVQEDVATRAATTAGATQAVVVTFGSLAEAEACVQGIKGCRVGGKELDAHVVLDSERVLPSNPAFKCDQEHAHSSDVAAAVAGQGDSMMKQEAGTEPSPCVDQDTAAAVASSTEWRVVIRGLIDEDDLQDDDDDYAEVCSDVTALVSSYGAVVGLDIPRGRETGSCCYGAEPGEAVVVFRSLQEAEACARGLSGRKVAGNILDAQVLTQPAPSQQGPLQGGASGTGPPVANRERKPAKECPLPQHQASSHQSCGKVPELDGSGPGMLRGFGNRVEDCCGRPKIACTDSDEPQAIAAAAPPGQSIEGPKTTALAKAGKRIQTKYQEAAALPKPPGVRGGLPNAYVNQPPDKEVNDLVFEMLQLLFKFQERARLSDPSKAKTRRRLVIGLREVLRGVKAKKVRLLIVAPNVDAVGGEGGLDDKVVEIIDKAREAEYPVVFALSKRKIGKALGKTIKVSAVGVYSFDGANEQQKQLKRRMETISSLPSPSPRQSDPPTDDALASPPSSSACGDSQDPAGKGSRV,negative +TCCCACGCATTCTCCACATCAGTTGAATGGTGTGGTCACTTCCAGTCCCGCAGGGCACACCCTTTCTGTCCTTCCGTCAC,MLNQLDNLTERVRGSNKLVDRWLHVRKHLLVAYYNLVGIKPGKESYMRLNEKALDDFCQSLVDYLSAGHFSIYERILHKLEGNGQLARAAKIWPQLEANTQQIMDYYDSSLETAIDHDNYLEFQQVLSDIGEALEARFVLEDKLILLVLDAARVKHPA,negative +UUAGCACAAACAACCCCAGAAGUGCAACGC,RRIKRLEQEKLELSRKLQESTQTVQALQYSTVDGPLTASKDLEIKNLKEEIEKLRKQVTESSHLEQQLEEANAVRQELDDAFRQIKAYEKQIKTLQQEREDLNKELVQASERLKNQSKELKDAHCQRKLAMQEFMEINER,negative +GUCAAGUGCACACCCUUGCUCGUUUCUCGAUCGCCACAACCGAUUCCAAG,MKTLLLLLLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAKEPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHSRFQPSQSSTYSQPGQSFSIQYGTGSLSGIIGADQVSAFATQVEGLTVVGQQFGESVTEPGQTFVDAEFDGILGLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSHFSGSLNWVPVTKQAYWQIALDNIQVGGTVMFCSEGCQAIVDTGTSLITGPSDKIKQLQNAIGAAPVDGEYAVECANLNVMPDVTFTINGVPYTLSPTAYTLLDFVDGMQFCSSGFQGLDIHPPAGPLWILGDVFIRQFYSVFDRGNNRVGLAPAVP,negative +ACAAAGCUGGAGUACUUACCGAACAUCCGUCUAACCCCU,GRQVDIDGEDYQRRDSIAQLLEDWGLIVIEDSAREDLFGLTNNFRVISFKQKDDWTLKAKYTIGN,negative +GCAGUUAACCAAGCCUGCAUACUGGAUAGACGGCUUAUUUGACUGAAUGCCUCCCGAAAGGUGCAGUU,MSSTESPVPAAAAPAEAVPASTPAPAAEQPAVGNGEQRNNADAANNTSLYVGELDPSVTEAMLFEIFSMIGTVASIRVCRDAVTRRSLGYAYVNFLNAADGERAMEQLNYSLIRNRPCRIMWSQRDPALRRTGQGNIFIKNLDAGIDNKALHDTFAAFGNILSCKVATNETGSLGYGFVHYETAEAAEAAIKHVNGMLLNDKKVYVGHHIPRKERQAKIEETRANFTNVYAKNVDPEVTDDEFEKLFTKFGKITSCVLQRDEDGKSKGFGFVNFEDHNEAQKAVDELHDSDFKGQKLFVARAQKKSEREEELRRSYEAAKNEKLAKFQGVNLYLKNIPESYDDERLREEFAPFGAITSCKIMRAPSGVSRGFGFVCYSAPEEANKAVSEMNGKMLDNRPLYVALAQRKDVRRQQLEAQIMQRNQLRLQQQAAAQGMGYPGPGMYYPQPGAFPGQPGGMVPRPRYAPAGMMPQGMPMAPYGQPGQFPAGMMPQGYRPARPPRGAPNAAGGPAPPAGARPPTGVNGAPRPAGQPVPGQPMPRGPAARPAGRPEADQPGALTAAALAKASPEEQKQMLGEAIYPKVAASQPELAGKLTGMILELPVTELLHLLEESEALDAKVNEALEVLKEYQQNDSAGAEAEANAEAPKTEA,negative +GGGAGAGAGGAAGAGGGAUGGGCGACCGAACGUGCCCUUCAAAGCCGUUCACUAACCAGUGGCAUAACCCAGAGGUCGAUAGUACUGGUCCCCCC,MNIKAILSLCLFLILQCVRARVFVSRLEAASLLARSRRANSPFSMEETKQGSLERECREETCNFEEAREIFEDDQRTNAFWTLYIRPNPCLSNPCQNGGTCQHTHTVYMCVCPRGWEGRVCSQEVSTGQSCKVNNGRCDHYCEEEEAAAGGRRGAVCSCAPGYHLARNRRSCMAMEAFPCGRVASPKSDILMGNSSEAATDVPTPTSQAANVNSSSIIGDDSEPQASFGHSNHRGRVVGGKECPRGQCPWQVLISRKGAPVCGGTILSPQWILTAAHCTIYETKNLRILAGEHNVDEVEGSEQELGILRIVDHPSFNIKLSYDNDISLIQLSRPIQFTRYALPICLPNQRFVRGVLRSVVAGTVSGWGKLNEFGPAAGILQRLEVPYVDDEQCRAAMGSKVITANMFCAGYETGGQDSCSGDSGGPHATRYGSTWFLTGVVSWGKGCAREGKFGVYTKVLNYLDWIAQTMAETESHALPEPAQH,negative +TATCAACTAACGTACTGCCGCATTCCCACAATCCACAGGCTCC,MDHLNEATQGKEHSEMSNNVSDPKGPPAKIARLEQNGSPLGRGRLGSTGAKMQGVPLKHSGHLMKTNLRKGTMLPVFCVVEHYENAIEYDCKEEHAEFVLVRKDMLFNQLIEMALLSLGYSHSSAAQAKGLIQVGKWNPVPLSYVTDAPDATVADMLQDVYHVVTLKIQLHSCPKLEDLPPEQWSHTTVRNALKDLLKDMNQSSLAKECPLSQSMISSIVNSTYYANVSAAKCQEFGRWYKHFKKTKDMMVEMDSLSELSQQGANHVNFGQQPVPGNTAEQPPSPAQLSHGSQPSVRTPLPNLHPGLVSTPISPQLVNQQLVMAQLLNQQYAVNRLLAQQSLNQQYLNHPPPVSRSMNKPLEQQVSTNTEVSSEIYQWVRDELKRAGISQAVFARVAFNRTQGLLSEILRKEEDPKTASQSLLVNLRAMQNFLQLPEAERDRIYQDERERSLNAASAMGPAPLISTPPSRPPQVKTATIATERNGKPENNTMNINASIYDEIQQEMKRAKVSQALFAKVAATKSQGWLCELLRWKEDPSPENRTLWENLSMIRRFLSLPQPERDAIYEQESNAVHHHGDRPPHIIHVPAEQIQQQQQQQQQQQQQQQAPPPPQPQQQPQTGPRLPPRQPTVASPAESDEENRQKTRPRTKISVEALGILQSFIQDVGLYPDEEAIQTLSAQLDLPKYTIIKFFQNQRYYLKHHGKLKDNSGLEVDVAEYKEEELLKDLEESVQDKNTNTLFSVKLEEELSVEGNTDINTDLKD,negative +CCUGUGUCUUGUGUGUGUGUUUUGUUUCUGGUCUA,MPEEWVRIFGEAGITQFEQQRNPRLCLSVLNILSKSEHPQEKFMFVPYEQSALPVTDNSPFGDTSITHNYADHHFKASTPENEGSSFYSRVPGPCTVGVRSSSLSSGRGSSEGVGSRSGSGSGGAASRSSSSGHGGAGFPLPVTSVPANGRSSAPGPNSMTVTSGSHSSSGSNCSTGSLTGGMELTNTMVATTQRTGPNNVLVNGHSTGNHFHGGVTQRVAASAAPTECNVLPTYTGSSSSYQPTSFQSMAVHTPPAYTLRQIPPAHSIGYPYTSTAPTSESIILTAPTTTPSSTVYHTTQGSAIVKPLSDNQSQRDKLPYLMHKSQWHSNVTGHVPLSPGLPRRFVDGVLPPETSAHIQYSSGQSSPSPAGSATPVPTPRRESLAGSVPVRAGPAPPALATHELSSDANCTLTPPPVATRPEKTKSIYTKPVEAQCDGHLTIGDQQDASRRSLETPVPPQTAATIHGSENETRTNVTVLPTVHSDGNNSSVHAYQQATESRPLKPNTLERQGQKKVRPKISDEAIQEKLRMIVSIGDPNRKYQRQEKIGQGASGTVYGGIEVATGRRVAIKQMNLKQQPKKELIVNEIYVMKAKKHPNVVNYLDSYLVADELWVVMEYLDGGSLTEVVTETYMEEGQIAAVCRECLQALDFLHKNQVIHRDIKSDNILLGLDGSVKLTDFGFCAQLSSEQNKRSTMVGTPYWMAPEVVTRKQYGPKVDIWSLGIMAIEMLDGEPPYLNENPVRALYLIGTNGKPEIKERDKLSSEFQDFLDLCLEVKVERRATAQELLQHIFSRDGHRAMELLQTDNFHSSGVRKKRTPRLAIEKLVDPEVKRNYQNQLVECLPDGTVSDINGHWEKISKALLKPRRTVVMAAGEDELVVTVRGTSFNCPPTSLVEPNTGIIAPLIEPHHRGIGSYALEVVADIIGTLDYCGIAFLTMGSFVPYLYYSFYCVLWLKLFYLALIFALGSGAIAVSMSNTFASPAYRPLRALVFIALGLSGVIPCVHVTITNGFWPSLQHGSLGWLFLMAVLYITGASIYAVRVPERIFPGRFDIWFQSHQIFHVFVVAAALVHYHGIIGLTNYRLAIGDCRPPPGYPFPKHDYDNIELLRPFMTY,negative +TCCGGCGCGCTGAGTGCCGGTTATCCTCGT,MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYTFLLPEMDNCRSSSSPYVSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQDNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVLVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF,negative +AUCAGUCCCCACUGCCCCCGCUUGCAGACA,IMEIRTVAVGIVAIKGVESEYYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHSGGEMFVALNQKGLPVKGKKTKKEQKTAHFLPMAIT,negative +CACCGCAUUGAGCCCAGAGACGCCACAGAC,EFPPSTFYRVTLYGLYKGELLDPVFAEAITEAEPEVEHITVSDITPHSFKVTWTAPEAVFDSFALKVLDSSGLGRPHQISVSGDKRTEAVTGLNEDTDYEIELFGIILGRKFQPIFTVARTGLGTRKGIRFSDVTDTSATVHWTMPHTRVDNYRVIYVPIQGGSPLTLRVDGGESQAMLSNLTPGVTYQVTVIAVKGLEESEPGSERVTTALDKPRGLTAVNISDTEALLLWQPSIATVDGYVITYSADSVAPVMERVSGNTVEFEMSSLTPATLYTVKVYAFRDTAKSAATSTDFTTDVDAPQNLAASNIQTETAMLTWKPPRADISGYILSFESADGVVKEVVLSPTATFYSMSHLTASTEYTVKLQAIAGPKRSRVISTVFLTIGVLYKHPKDCSQALLNGDTTSGFYTIYLRGDESQPLQVYCDMTTDGGGWIVFVRRQSGKVEFFRNWKNYTAGFGDLNDEFWLGLSNLHKITSFGQYELRVDLRDKGESAYAQYDKFSISEPRARYKVHVGGYSGTAGDSMTYHHGRPFSTYDNDNDIAVTNCALSYKGAFWYKNCHRVNIMGRYGDNSHSKGVNWFHWKGHEHSVEFAEMKIRPANFRNFEGRKKRS,negative +CGTATAGGTCCCCTGCCGCTAAACAGCGCCGCGGTA,MEGMLKGEGPGPLPPLLQQYVELRDQYPDYLLLFQVGDFYECFGEDAERLARALGLVLTHKTSKDFTTPMAGIPLRAFEAYAERLLKMGFRLAVADQVEPAEEAEGLVRREVTQLLTPGTLLQESLLPREANYLAAIATGDGWGLAFLDVSTGEFKGTVLKSKSALYDELFRHRPAEVLLAPELLENGAFLDEFRKRFPVMLSEAPFEPEGEGPLALRRARGALLAYAQRTQGGALSLQPFRFYDPGAFMRLPEATLRALEVFEPLRGQDTLFSVLDETRTAPGRRLLQSWLRHPLLDRGPLEARLDRVEGFVREGALREGVRRLLYRLADLERLATRLELGRASPKDLGALRRSLQILPELRALLGEEVGLPDLSPLKEELEAALVEDPPLKVSEGGLIREGYDPDLDALRAAHREGVAYFLELEERERERTGIPTLKVGYNAVFGYYLEVTRPYYERVPKEYRPVQTLKDRQRYTLPEMKEKEREVYRLEALIRRREEEVFLEVRERAKRQAEALREAARILAELDVYAALAEVAVRYGYVRPRFGDRLQIRAGRHPVVERRTEFVPNDLEMAHELVLITGPNMAGKSTFLRQTALIALLAQVGSFVPAEEAHLPLFDGIYTRIGASDDLAGGKSTFMVEMEEVALILKEATENSLVLLDEVGRGTSSLDGVAIATAVAEALHERRAYTLFATHYFELTALGLPRLKNLHVAAREEAGGLVFYHQVLPGPASKSYGVEVAAMAGLPKEVVARARALLQAMAARREGALDAVLERLLALDPDRLTPLEALRLLQELKALALGAPLDTMKG,negative +AGCCGUCGCUAGUUUGAUUCCGUGUGUUAGUGGUU,AKTALQVPLPHPMQMNALGGYSPASTCNGYGRMGLHQEKLPSDLDGMFIERLDCDMESIIRNDLMDGDTLDFNFDNVLPNQSFPHSVKTTTHSWVSG,negative +UCGGAGGUGGUUCAGCUCUGCAUCGACAGUUGGC,QDRPIKFSTEGATSQSYKQFIEALRERLRGGLIHDIPVLPDPTTLQERNRYITVELSNSDTESIEVGIDVTNAYVVAYRAGTQSYFLRDAPSSASDYLFTGTDQHSLPFYGTYGDLERWAHQSRQQIPLGLQALTHGISFFRSGGNDNEEKARTLIVIIQMVAEAARFRYISNRVRVSIQTGTAFQPDAAMISLENNWDNLSRGVQESVQDTFPNQVTLTNIRNEPVIVDSLSHPTVAVLALMLFVCNPPNANQSPLLIRSIVEKSKICSSRYEPTVRIGGRDGMCVDVYDNGYHNGNRIIMWKCKDRLEENQLWTLKSDKTIRSNGKCLTTYGYAPGSYVMIYDCTSAVAEATYWEIWDNGTIINPKSALVLSAESSSMGGTLTVQTNEYLMRQGWRTGNNTSPFVTSISGYSDLCMQAQGSNVWMADCDSNKKEQQWALYTDGSIRSVQNTNNCLTSKDHKQGSTILLMGCSNGWASQRWVFKNDGSIYSLYDDMVMDVKGSDPSLKQIILWPYTGKPNQIWLTLF,negative +TTGCACAAGATACGGCTACCTGTATGCGGCAATCGGCATTAAATCTATCTAAGCCAGCAGTAAC,MAMQMQLEANADTSVEEESFGPQPISRLEQCGINANDVKKLEEAGFHTVEAVAYAPKKELINIKGISEAKADKILAEAAKLVPMGFTTATEFHQRRSEIIQITTGSKELDKLLQGGIETGSITEMFGEFRTGKTQICHTLAVTCQLPIDRGGGEGKAMYIDTEGTFRPERLLAVAERYGLSGSDVLDNVAYARAFNTDHQTQLLYQASAMMVESRYALLIVDSATALYRTDYSGRGELSARQMHLARFLRMLLRLADEFGVAVVITNQVVAQVDGAAMFAADPKKPIGGNIIAHASTTRLYLRKGRGETRICKIYDSPCLPEAEAMFAINADGVGDAKD,negative +AAGCTCTTAGTTGATGCGCGGTCAAAATTTAAGCT,MEGMLKGEGPGPLPPLLQQYVELRDQYPDYLLLFQVGDFYECFGEDAERLARALGLVLTHKTSKDFTTPMAGIPLRAFEAYAERLLKMGFRLAVADQVEPAEEAEGLVRREVTQLLTPGTLLQESLLPREANYLAAIATGDGWGLAFLDVSTGEFKGTVLKSKSALYDELFRHRPAEVLLAPELLENGAFLDEFRKRFPVMLSEAPFEPEGEGPLALRRARGALLAYAQRTQGGALSLQPFRFYDPGAFMRLPEATLRALEVFEPLRGQDTLFSVLDETRTAPGRRLLQSWLRHPLLDRGPLEARLDRVEGFVREGALREGVRRLLYRLADLERLATRLELGRASPKDLGALRRSLQILPELRALLGEEVGLPDLSPLKEELEAALVEDPPLKVSEGGLIREGYDPDLDALRAAHREGVAYFLELEERERERTGIPTLKVGYNAVFGYYLEVTRPYYERVPKEYRPVQTLKDRQRYTLPEMKEKEREVYRLEALIRRREEEVFLEVRERAKRQAEALREAARILAELDVYAALAEVAVRYGYVRPRFGDRLQIRAGRHPVVERRTEFVPNDLEMAHELVLITGPNMAGKSTFLRQTALIALLAQVGSFVPAEEAHLPLFDGIYTRIGASDDLAGGKSTFMVEMEEVALILKEATENSLVLLDEVGRGTSSLDGVAIATAVAEALHERRAYTLFATHYFELTALGLPRLKNLHVAAREEAGGLVFYHQVLPGPASKSYGVEVAAMAGLPKEVVARARALLQAMAARREGALDAVLERLLALDPDRLTPLEALRLLQELKALALGAPLDTMKG,negative +CGTCTTGCATAATATAAAATTTTGTTTTGAGTTGTAATCGAATGCGGTCT,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,negative +CTTCTGCCCGCCTCCTTCCTGGTAAAGTCATTAATAGGTGTGGGGTGCCGGGCATTTCGGAGACGAGATAGGCGGACACT,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +UGUUGUUGGACCAGUGUUAUUUUACGCGAUUGUGCGGUUGUGA,MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICEVEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASSIVYKKEGEQVEFSFPLAFTVEKLTGSGELWWQAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLPQALPQYAGSGNLTLALEAKTGKLHQEVNLVVMRATQLQKNLTCEVWGPTSPKLMLSLKLENKEAKVSKREKAVWVLNPEAGMWQCLLSDSGQVLLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQAERMSQIKRLLSEKKTCQCPHRFQKTCSPI,negative +ATTGACCGCTGTGTGACGCAACACTCAAT,MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYTFLLPEMDNCRSSSSPYVSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQDNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVLVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF,negative +CAUGAGGUCUAUCACUGCAUCGACAGCUAGGCGGACAAUG,MHGDTPTLHEYMLDLQPETTDLYCYEQLNDSSEEEDEIDGPAGQAEPDRAHYNIVTFCCKCDSTLRLCVQSTHVDIRTLEDLLMGTLGIVCPICSQKP,negative +GGGAGACAAGAATAAACGCTCAACAGAGAAGAAGCACCGATGCAACGCGAAAAGCACACGGCCTTCGACAGGAGGCTCACAACAGGC,MKPGGNTIVIWMYAVATWLCFGSTSGWSFTLEDNNIFPKQYPIINFTTAGATVQSYTNFIRAVRGRLTTGADVRHEIPVLPNRVGLPINQRFILVELSNHAELSVTLALDVTNAYVVGYRAGNSAYFFHPDNQEDAEAITHLFTDVQNRYTFAFGGNYDRLEQLAGNLRENIELGNGPLEEAISALYYYSTGGTQLPTLARSFIICIQMISEAARFQYIEGEMRTRIRYNRRSAPDPSVITLENSWGRLSTAIQESNQGAFASPIQLQRRNGSKFSVYDVSILIPIIALMVYRCAPPPSSQFSLLIRPVVPNFNADVCMDPEPIVRIVGRNGLCVDVRDGRFHNGNAIQLWPCKSNTDANQLWTLKRDNTIRSNGKCLTTYGYSPGVYVMIYDCNTAATDATRWQIWDNGTIINPRSSLVLAATSGNSGTTLTVQTNIYAVSQGWLPTNNTQPFVTTIVGLYGLCLQANSGQVWIEDCSSEKAEQQWALYADGSIRPQQNRDNCLTSDSNIRETVVKILSCGPASSGQRWMFKNDGTILNLYSGLVLDVRASDPSLKQIILYPLHGDPNQIWLPLF,negative +GCAGAGAAAGGGUAAGUAUGAUGUCUACCGGAAUGUGUGGGCUUGGUGCG,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,negative +ATCTCGGGTTTGGACTCCTGTTTATTTATAAGGAGACGAGAT,MGVLLTQRTLLSLVLALLFPSMASMAAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQGLDVPKLREHCRERPGAFPSEETLRGLGRRGFLQTLNATLGCVLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILGLRNNIYCMAQLLDNSDTAEPTKAGRGASQPPTPTPASDAFQRKLEGCRFLHGYHRFMHSVGRVFSKWGESPNRSRRHSPHQALRKGVRRTRPSRKGKRLMTRGQLPR,negative +GGGAGAGGAGAGAACGUUCUACGUCGUGAGUAAUGGCUCGUAGAUGAGGUCGCUGUCGAUCGAUCGAUCGAUG,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,negative +GGGAGAAGGGAAGTAACAGGAGCAUUAGCUACCAAGGGGUCGGGUUGUGGGUGAGAAGAGGTGACGGTACCAG,SRWDSTQQRAVLAAAVEIMVKFSSQPHLAQVVAEDLLSPSVMDVGDFKISITEGLPSGVPCTSQWNSIAHWLLTLCALSETTNLSPDIIQANSLFSFYG,negative +GCTGGTCTCTGCGGGTTGTTGCGCCGCGGCACCCTTGGCA,MVMGLGVLLLVFVLGLGLTPPTLAQDNSRYTHFLTQHYDAKPQGRDDRYCESIMRRRGLTSPCKDINTFIHGNKRSIKAICENKNGNPHRENLRISKSSFQVTTCKLHGGSPWPPCQYRATAGFRNVVVACENGLPVHLDQSIFRRP,negative +GAAUCAAUACACAGUCCUGGGUGCUAACCAUGAACACCCAAGGCCUUAGUGGUAUGUGGUUCUUG,MVKSHIGSWILVLFVAMWSDVGLCKKRPKPGGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGSHSQWNKPSKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGNDYEDRYYRENMYRYPNQVYYRPVDRYSNQNNFVHDCVNITVKQHTVTTTTKGENFTETDIKIMERVVEQMCITQYQRESQAYYQRGASVILFSSPPVILLISFLIFLIVG,negative +ACGAAGCUUGAUCCCGUUUGCCGGUCGAUCGCUUCGA,VVIRSNNFTDNAKTIIVQLNESIAINCTRPNNNTRKSIHIGPGRAFYTTGDIIGNIRQAHCNLSRTKWENTLKQIAKKLREQFGNKTIVFNH,negative +UCCAGGGAUUGAAGUGUCGGGGUAGGAACAUAAAGGCGGC,PHITDVVLDKANKTPLRQLDPSRLPDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFAKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRQSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPINRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDTASEATRPATLNRFSALQQTLPAENTDNRRVVQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRTRTPATKRSFSKEVEERSRERPSQPEGLRKAASLTEDRGRDPVKREATLPPVSPPKAALSVDEVEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRLGIESTLERSTIAREHMGRLLHQLLCAGHLSTAQYYQGLYETLELAEDMEIDIPHVWLYLAELITPILQEDGVPMGELFREITKPLRPMGKATSLLLEILGLLCKSMGPKKVGMLWREAGLSWREFLAEGQDVGSFVAEKKVEYTLGEESEAPGQRTLAFEELRRQLEKLLKDGGSNQRVFDWIDANLNEQQIASNTLVRALMTTVCYSAIIFETPLRVDVQVLKVRARLLQKYLCDEQKELQALYALQALVVTLEQPANLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFNWLREAEDEESDHN,negative +GCCCACGGACGAATGCTTTGATGTTGTG,PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGKISKIGPENPYNTPVFAIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDESFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPXRXKNPEMVIYQYMDDLYVGSDLEIGQHRAKIEELRSHLLSWGFTTPDKKHQKEPPFLWMGYELHPDSWTVQPIELPEKDSWTVNE,negative +GGGAGAGGAGGGAGAUAGAUAUCAAACAAGAUCGCGUCUACUGGCACAGAAAGAGCAAUGCGGAACUAUAGCUGAGAGUUUCGUGGAUGCCACAGGAC,MASTSRLDALPRVTCPNHPDAILVEDYRAGDMICPECDRVIDVGSEWRTFSNDKATKDPSRVGDSQNPLLSDGDLSTMIGKGTGAASFDEFGNSKYQNRRTMSSSDRAMMNAFKEITTMADRINLPRNIVDRTNNLFKQVYEQKSLKGRANDAIASACLYIACRQEGVPRTFKEICAVSRISKKEIGRCFKLILKALETSVDLITTGDFMSRFCSNLCLPKQVQMAATHIA,negative +GGACAANNAGCGGUGUCUUUUCAUUUNNAUCCUCCGACNUCC,MKKRKVLIPLMALSTILVSSTGNLEVIQAEVKQENRLLNESESSSQGLLGYYFSDLNFQAPMVVTSSTTGDLSIPSSELENIPSENQYFQSAIWSGFIKVKKSDEYTFATSADNHVTMWVDDQEVINKASNSNKIRLEKGRLYQIKIQYQRENPTEKGLDFKLYWTDSQNKKEVISSDNLQLPELKQKSSNSRKKRSTSAGPTVPDRDNDGIPDSLEVEGYTVDVKNKRTFLSPWISNIHEKKGLTKYKSSPEKWSTASDPYSDFEKVTGRIDKNVSPEARHPLVAAYPIVHVDMENIILSKNEDQSTQNTDSQTRTISKNTSTSRTHTSEVHGNAEVHASFFDIGGSVSAGFSNSNSSTVAIDHSLSLAGERTWAETMGLNTADTARLNANIRYVNTGTAPIYNVLPTTSLVLGKNQTLATIKAKENQLSQILAPNNYYPSKNLAPIALNAQDDFSSTPITMNYNQFLELEKTKQLRLDTDQVYGNIATYNFENGRVRVDTGSNWSEVLPQIQETTARIIFNGKDLNLVERRIAAVNPSDPLETTKPDMTLKEALKIAFGFNEPNGNLQYQGKDITEFDFNFDQQTSQNIKNQLAELNATNIYTVLDKIKLNAKMNILIRDKRFHYDRNNIAVGADESVVKEAHREVINSSTEGLLLNIDKDIRKILSGYIVEIEDTEGLKEVINDRYDMLNISSLRQDGKTFIDFKKYNDKLPLYISNPNYKVNVYAVTKENTIINPSENGDTSTNGIKKILIFSKKGYEIG,negative +GGACCGAGAAGUUACCCUGUAAUCUUAGGAUGAAUCGCAUGCUCUAGCGACCUUUUCGGCUUCGGCGUACGCACAUCGCAGCAAC,MRKIVVAAIAVSLTTVSITASASADPSKDSKAQVSAAEAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKVKPSAASIDAAKKAGVNNGNPLDAVQQ,negative +CATGCGCCTTCCCCCTGTGGTTGGTGTCAGCCGGCCTGTG,PHITDVVLDKANKTPLRQLDPSRLPDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFAKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRQSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPINRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDTASEATRPATLNRFSALQQTLPAENTDNRRVVQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRTRTPATKRSFSKEVEERSRERPSQPEGLRKAASLTEDRGRDPVKREATLPPVSPPKAALSVDEVEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRLGIESTLERSTIAREHMGRLLHQLLCAGHLSTAQYYQGLYETLELAEDMEIDIPHVWLYLAELITPILQEDGVPMGELFREITKPLRPMGKATSLLLEILGLLCKSMGPKKVGMLWREAGLSWREFLAEGQDVGSFVAEKKVEYTLGEESEAPGQRTLAFEELRRQLEKLLKDGGSNQRVFDWIDANLNEQQIASNTLVRALMTTVCYSAIIFETPLRVDVQVLKVRARLLQKYLCDEQKELQALYALQALVVTLEQPANLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFNWLREAEDEESDHN,negative +CCTTCGTTGTCTGCCTTCGTAGCGGATCGAATTACGCGTTAACGGCAACCGATAACGGGACCGATTGCACACCCTTCAGAATTCGCACCA,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,negative +GGGACGCGTGGTACCGACGGAGGCTTGTTTATGTAGGGATGTAAGGGGATGGGCAATGTGGCGACAGCTT,MELAAWCRWGFLLALLPPGIAGTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYVPANASLSFLQDIQEVQGYMLIAHNQVKRVPLQRLRIVRGTQLFEDKYALAVLDNRDPQDNVAASTPGRTPEGLRELQLRSLTEILKGGVLIRGNPQLCYQDMVLWKDVFRKNNQLAPVDIDTNRSRACPPCAPACKDNHCWGESPEDCQILTGTICTSGCARCKGRLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMHNPEGRYTFGASCVTTCPYNYLSTEVGSCTLVCPPNNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLRGARAITSDNVQEFDGCKKIFGSLAFLPESFDGDPSSGIAPLRPEQLQVFETLEEITGYLYISAWPDSLRDLSVFQNLRIIRGRILHDGAYSLTLQGLGIHSLGLRSLRELGSGLALIHRNAHLCFVHTVPWDQLFRNPHQALLHSGNRPEEDLCVSSGLVCNSLCAHGHCWGPGPTQCVNCSHFLRGQECVEECRVWKGLPREYVSDKRCLPCHPECQPQNSSETCFGSEADQCAACAHYKDSSSCVARCPSGVKPDLSYMPIWKYPDEEGICQPCPINCTHSCVDLDERGCPAEQRASPVTFIIATVVGVLLFLILVVVVGILIKRRRQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVREHRGRLGSQDLLNWCVQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPSSPMDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFSPDPTPGTGSTAHRRHRSSSTRSGGGELTLGLEPSEEGPPRSPLAPSEGAGSDVFDGDLAMGVTKGLQSLSPHDLSPLQRYSEDPTLPLPPETDGYVAPLACSPQPEYVNQSEVQPQPPLTPEGPLPPVRPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLVPREGTASPPHPSPAFSPAFDNLYYWDQNSSEQGPPPSNFEGTPTAENPEYLGLDVPV,negative +TATTAGTAATACTATTAGTAATAC,MIPPPRRSASSTPKDYRSSRDLQPWRGVSSGDAAETSQQSRHRRDAIADGGGRLKGAAQSSPSSGTRRSGPYAQGRAMPKNENIPKPGKQRLGPRKKKLSTLKKKILLDRLERWRDKQHEGALSTPSATASSEEAKCNNPFPLCPPGELSPPPSPPATICPAVVDKSTSYGQVGGANGERSVWAITIYNLVDQEDVEDDDDHAEIERDLWDMSSAFGVVRSVQVPRGTAVQVSDAEVSAAAAAGEPAAVAAKVAFATNAEAECARDGLNGRIVGGKPLLVRIHRCDGHFCGGVCPGDPDGSGLWRVAIENLIDEEDDLDDEDEYAEISANVSAMMGCYGKLVDVQVRRSSPSKGEVQEDVATRAATTAGATQAVVVTFGSLAEAEACVQGIKGCRVGGKELDAHVVLDSERVLPSNPAFKCDQEHAHSSDVAAAVAGQGDSMMKQEAGTEPSPCVDQDTAAAVASSTEWRVVIRGLIDEDDLQDDDDDYAEVCSDVTALVSSYGAVVGLDIPRGRETGSCCYGAEPGEAVVVFRSLQEAEACARGLSGRKVAGNILDAQVLTQPAPSQQGPLQGGASGTGPPVANRERKPAKECPLPQHQASSHQSCGKVPELDGSGPGMLRGFGNRVEDCCGRPKIACTDSDEPQAIAAAAPPGQSIEGPKTTALAKAGKRIQTKYQEAAALPKPPGVRGGLPNAYVNQPPDKEVNDLVFEMLQLLFKFQERARLSDPSKAKTRRRLVIGLREVLRGVKAKKVRLLIVAPNVDAVGGEGGLDDKVVEIIDKAREAEYPVVFALSKRKIGKALGKTIKVSAVGVYSFDGANEQQKQLKRRMETISSLPSPSPRQSDPPTDDALASPPSSSACGDSQDPAGKGSRV,negative +CAGCUAGAGGCAAAGUGGUCUCGACGUAGGGGGACCUGCUCGCUG,MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQRGLKNVFDEAILAALEPPETQPKRKCCIF,negative +GGACAANNAGCGGUGUCUUUUCAUUUNNAUCCUCCGACNUCC,MAAKVASTSSEEAEGSLVTEGEMGEKALPVVYKRYICSFADCGAAYNKNWKLQAHLCKHTGEKPFPCKEEGCEKGFTSLHHLTRHSLTHTGEKNFTCDSDGCDLRFTTKANMKKHFNRFHNIKICVYVCHFENCGKAFKKHNQLKVHQFSHTQQLPYECPHEGCDKRFSLPSRLKRHEKVHAGYPCKKDDSCSFVGKTWTLYLKHVAECHQDLAVCDVCNRKFRHKDYLRDHQKTHEKERTVYLCPRDGCDRSYTTAFNLRSHIQSFHEEQRPFVCEHAGCGKCFAMKKSLERHSVVHDPEKRKLKEKCPRPKRSLASRLTGYIPPKSKEKNASVSGTEKTDSLVKNKPSGTETNGSLVLDKLTIQ,negative +GGGAGACAAGAATAAACGCTCAACAGAGAAGAAGCACCGATGCAACGCGAAAAGCACACGGCCTTCGACAGGAGGCTCACAACAGGC,MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPGPHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR,negative +ACAAAUCCCCAGGAGUGCAAUACUCCGCAA,MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM,negative +GCGACUGGUUACCCGGUCG,MAPFLRIAFNSYELGSLQAEDEANQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKSTFDAHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNGKAEFWLDLQPQAKVLMSVQYFLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQVTQRASRRSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTYGKIWEGSSKCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGVTGNIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKNLIDSMDQSAFAGFSFVNPKFEHLLED,negative +ACACGGGCCGTGAACGCAGCGAGTTCGCCCGTCGTGACATT,MGVLLTQRTLLSLVLALLFPSMASMAAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQGLDVPKLREHCRERPGAFPSEETLRGLGRRGFLQTLNATLGCVLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILGLRNNIYCMAQLLDNSDTAEPTKAGRGASQPPTPTPASDAFQRKLEGCRFLHGYHRFMHSVGRVFSKWGESPNRSRRHSPHQALRKGVRRTRPSRKGKRLMTRGQLPR,negative +GGGAGAAGGGAAGTAACAGGUGGGCGCGUGAUUAUGUUUGUACGAAGACUGTGAGAAGAGGTGACGGTACCAG,MSARGEEAAGEASGSQEQPEPALAEPKKRGPGRPRKPQQEPTGEPVPKRPRGRPKGSKNKGPSKAAQKKAETTGEKRPRGRPRKWPQQVVQEKPAQEEEEEEEEEEAEED,negative +UCACUCUAUACCUCAAACGAAGUUGCACAACCCC,PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGKISKIGPENPYNTPVFAIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDESFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPXRXKNPEMVIYQYMDDLYVGSDLEIGQHRAKIEELRSHLLSWGFTTPDKKHQKEPPFLWMGYELHPDSWTVQPIELPEKDSWTVNE,negative +GAGCAUUAACAAAAAGAUCACUAGGAACAGCGGUA,MVKSHIGSWILVLFVAMWSDVGLCKKRPKPGGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGSHSQWNKPSKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGNDYEDRYYRENMYRYPNQVYYRPVDRYSNQNNFVHDCVNITVKQHTVTTTTKGENFTETDIKIMERVVEQMCITQYQRESQAYYQRGASVILFSSPPVILLISFLIFLIVG,negative +AGUCUGAGUCAAAUUGUGCCACUCCCACUCCAAUUGCGU,LQENFLPQPRQQHHGTLVLHYRPHREEAGMQHPCLWPGSSHCSDDSTLRRLQCESVTSIGAVCP,negative +GCAGUUAACCAAGCCUGCAUACUGGAUAGACGGCUUAUUUGACUGAAUGCCUCCCGAAAGGUGCAGUU,MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP,negative +CTCCTCTGACTGTAACCACGCAGCACCAGGAAGATGAATGCTCGAGCAACTCGACGGTCGGCATAGGTAGTCCAGAAGCC,MTPDIQAPFLSLLLLFPVLTVANVPTLTTSDSINPRRTTPVSTTQSSPTSSPTKETSWSTTTTLLTASSPAPSPAASPGHDGASTPTSSPAPSPAASPGHDGASTPTSSPAPSPAASPGHDGASTPTSSPAPSPAASPGHDGASTPTSSPAPSPAASPGHNGTSSPTGSPAPSPAASPGHDGASTPTSSPAPSPAASPGHNGTSSPTGSPAPSPAASPGHDGASTPTSSPAPSPAASPGHNGTSSPTGSPAPSPTASPGHDSAPSLTSSPAPSPTASPGQHGASSPTSSDTSSMTTRSMSSSMVTSAHKGTSSRATMTPVSKGTPSSVPSSETAPTAASHITRTAASSPSIALSTSSNPKTSQQLSVRVSLYFLSFRITNLQFNSSLENPQTSYYQELQRSIWGLILQIYKQRDFLGLSEIKFRPGSVVVELTLAFREGTTAEWVKAQFSQLEAHAASYNLTISGVSVYSAPFPSSAQAGSGVPGWGIALLVLVCVLVALAIIYLIALVVCQCGRKKCEQLDVFPTLDAYHPMSEYSTYHTHGRYVPPGSTKRSPYEEVSAGNGGSNLSYTNLAATSANL,negative +UAUGUUGUGUGUGUGUUGUUUUUGUGUUUUGUUUU,MKRASAGGSRLLAWVLWLQAWQVAAPCPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDNPWVCDCRARPLWAWLQKFRGSSSEVPCSLPQRLAGRDLKRLAANDLQGCAVATGPYHPIWTGRATDEEPLGLPKCCQPDAADKASVLEPGRPASAGNALKGRVPPGDSPPGNGSGPRHINDSPFGTLPGSAEPPLTAVRPEGSEPPGFPTSGPRRRPGCSRKNRTRSHCRLGQAGSGGGGTGDSEGSGALPSLTCSLTPLGLALVLWTVLGPC,negative +CACUACCACGCCAUAUCAGCUAAUGGCCCCUCCCUACGCA,MASTSRLDALPRVTCPNHPDAILVEDYRAGDMICPECDRVIDVGSEWRTFSNDKATKDPSRVGDSQNPLLSDGDLSTMIGKGTGAASFDEFGNSKYQNRRTMSSSDRAMMNAFKEITTMADRINLPRNIVDRTNNLFKQVYEQKSLKGRANDAIASACLYIACRQEGVPRTFKEICAVSRISKKEIGRCFKLILKALETSVDLITTGDFMSRFCSNLCLPKQVQMAATHIA,negative +ATACCAGTCTATTCAATTGCACTCTGTGGGGGTGGACGGGCCGGGTAGATAGTATGTGCAATC,MANLGYWLLALFVTMWTDVGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGTWGQPHGGGWGQPHGGSWGQPHGGSWGQPHGGGWGQGGGTHNQWNKPSKPKTNLKHVAGAAAAGAVVGGLGGYMLGSAMSRPMIHFGNDWEDRYYRENMYRYPNQVYYRPVDQYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCVTQYQKESQAYYDGRRSSSTVLFSSPPVILLISFLIFLIVG,negative +UCGUGCCUUUUCUCGAUGGAGUGAGAAGAGGUGACGG,MGLLGILCFLIFLGKTWGQEQTYVISAPKIFRVGASENIVIQVYGYTEAFDATISIKSYPDKKFSYSSGHVHLSSENKFQNSAILTIQPKQLPGGQNPVSYVYLEVVSKHFSKSKRMPITYDNGFLFIHTDKPVYTPDQSVKVRVYSLNDDLKPAKRETVLTFIDPEGSEVDMVEEIDHIGIISFPDFKIPSNPRYGMWTIKAKYKEDFSTTGTAYFEVKEYVLPHFSVSIEPEYNFIGYKNFKNFEITIKARYFYNKVVTEADVYITFGIREDLKDDQKEMMQTAMQNTMLINGIAQVTFDSETAVKELSYYSLEDLNNKYLYIAVTVIESTGGFSEEAEIPGIKYVLSPYKLNLVATPLFLKPGIPYPIKVQVKDSLDQLVGGVPVTLNAQTIDVNQETSDLDPSKSVTRVDDGVASFVLNLPSGVTVLEFNVKTDAPDLPEENQAREGYRAIAYSSLSQSYLYIDWTDNHKALLVGEHLNIIVTPKSPYIDKITHYNYLILSKGKIIHFGTREKFSDASYQSINIPVTQNMVPSSRLLVYYIVTGEQTAELVSDSVWLNIEEKCGNQLQVHLSPDADAYSPGQTVSLNMATGMDSWVALAAVDSAVYGVQRGAKKPLERVFQFLEKSDLGCGAGGGLNNANVFHLAGLTFLTNANADDSQENDEPCKEILRPRRTLQKKIEEIAAKYKHSVVKKCCYDGACVNNDETCEQRAARISLGPRCIKAFTECCVVASQLRANISHKDMQLGRLHMKTLLPVSKPEIRSYFPESWLWEVHLVPRRKQLQFALPDSLTTWEIQGVGISNTGICVADTVKAKVFKDVFLEMNIPYSVVRGEQIQLKGTVYNYRTSGMQFCVKMSAVEGICTSESPVIDHQGTKSSKCVRQKVEGSSSHLVTFTVLPLEIGLHNINFSLETWFGKEILVKTLRVVPEGVKRESYSGVTLDPRGIYGTISRRKEFPYRIPLDLVPKTEIKRILSVKGLLVGEILSAVLSQEGINILTHLPKGSAEAELMSVVPVFYVFHYLETGNHWNIFHSDPLIEKQKLKKKLKEGMLSIMSYRNADYSYSVWKGGSASTWLTAFALRVLGQVNKYVEQNQNSICNSLLWLVENYQLDNGSFKENSQYQPIKLQGTLPVEARENSLYLTAFTVIGIRKAFDICPLVKIDTALIKADNFLLENTLPAQSTFTLAISAYALSLGDKTHPQFRSIVSALKREALVKGNPPIYRFWKDNLQHKDSSVPNTGTARMVETTAYALLTSLNLKDINYVNPVIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVKQLRLSMDIDVSYKHKGALHNYKMTDKNFLGRPVEVLLNDDLIVSTGFGSGLATVHVTTVVHKTSTSEEVCSFYLKIDTQDIEASHYRGYGNSDYKRIVACASYKPSREESSSGSSHAVMDISLPTGISANEEDLKALVEGVDQLFTDYQIKDGHVILQLNSIPSSDFLCVRFRIFELFEVGFLSPATFTVYEYHRPDKQCTMFYSTSNIKIQKVCEGAACKCVEADCGQMQEELDLTISAETRKQTACKPEIAYAYKVSITSITVENVFVKYKATLLDIYKTGEAVAEKDSEITFIKKVTCTNAELVKGRQYLIMGKEALQIKYNFSFRYIYPLDSLTWIEYWPRDTTCSSCQAFLANLDEFAEDIFLNGC,negative +AGAAAAAAACAAUCCACAGAACAGCGCGUG,MKRASAGGSRLLAWVLWLQAWQVAAPCPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDNPWVCDCRARPLWAWLQKFRGSSSEVPCSLPQRLAGRDLKRLAANDLQGCAVATGPYHPIWTGRATDEEPLGLPKCCQPDAADKASVLEPGRPASAGNALKGRVPPGDSPPGNGSGPRHINDSPFGTLPGSAEPPLTAVRPEGSEPPGFPTSGPRRRPGCSRKNRTRSHCRLGQAGSGGGGTGDSEGSGALPSLTCSLTPLGLALVLWTVLGPC,negative +GGGACACAAUGGACGAAGUCAGUCGCAUUGGCCGAGCUGUCGCUCUGACCAACUGAUAACGGCCGACAUGAGAG,MLNQLDNLTERVRGSNKLVDRWLHVRKHLLVAYYNLVGIKPGKESYMRLNEKALDDFCQSLVDYLSAGHFSIYERILHKLEGNGQLARAAKIWPQLEANTQQIMDYYDSSLETAIDHDNYLEFQQVLSDIGEALEARFVLEDKLILLVLDAARVKHPA,negative +CUUCUCCCUUGAGGGCCCCAUGACCUGACUGUAGAUAUCUGCCCUCGAG,MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYTFLLPEMDNCRSSSSPYVSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQDNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVLVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF,negative +GCAATGGTACGGTACTTCCTGTGGCGAGGTAGGTGGGGTGTGTGTGTATCCAAAAGTGCACGCTACTTTGCTAA,MAIPKELLVLLLGIAILSKVAECAAFGSRRGLVETVFDVTRFGARPNTPADSTRGLMMAWRSACQSPGPAKVVIPPGTYTTGETIFQGPCTSPRPITIEIQGTLLSNTDMSLYTRAAWISIEHVDGIVITGGGTLNGQGKSSWQFADKSGSTPPLPSSLVFQTVRSSSIKNLNFVDAKGVHLKITDSSDISVSNIKITAPGDSPNTDGLHISDTINVNVTDSTIGTGDDCISIGDGNSNVYISNINCGPGHGISIGSLGKRLDETDVKGVTVRNCTFRGTTNGARIKTYMGSPSLQVSGVVYEDIILDNVKNPIVIDQHYHSKNRNEPSRVKLVDIHFRNIRGTTTSKIPVLLNCSEALPCEGVELVDIDLAPVGSIGPLLPATCQNAKTILNGKNNPPAC,negative +AGCGACCU,PHITDVVLDKANKTPLRQLDPSRLPDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFAKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRQSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPINRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDTASEATRPATLNRFSALQQTLPAENTDNRRVVQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRTRTPATKRSFSKEVEERSRERPSQPEGLRKAASLTEDRGRDPVKREATLPPVSPPKAALSVDEVEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRLGIESTLERSTIAREHMGRLLHQLLCAGHLSTAQYYQGLYETLELAEDMEIDIPHVWLYLAELITPILQEDGVPMGELFREITKPLRPMGKATSLLLEILGLLCKSMGPKKVGMLWREAGLSWREFLAEGQDVGSFVAEKKVEYTLGEESEAPGQRTLAFEELRRQLEKLLKDGGSNQRVFDWIDANLNEQQIASNTLVRALMTTVCYSAIIFETPLRVDVQVLKVRARLLQKYLCDEQKELQALYALQALVVTLEQPANLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFNWLREAEDEESDHN,negative +GUCAGCUGCUCGCGGGAUCGAUCCAUUCGGUGGCCAUGCUCCGGAAGACGGGCCGGCUUCGCAAGACUCAGG,MLDLFADAEPWQEPLAAGAVILRRFAFNAAEQLIRDINDVASQSPFRQMVTPGGYTMSVAMTNCGHLGWTTHRQGYLYSPIDPQTNKPWPAMPQSFHNLCQRAATAAGYPDFQPDACLINRYAPGAKLSLHQDKDEPDLRAPIVSVSLGLPAIFQFGGLKRNDPLKRLLLEHGDVVVWGGESRLFYHGIQPLKAGFHPLTIDCRYNLTFRQAGKKE,negative +CAUGUCUACAACAAUCUCGCCCGUUGAGUCUCGUCGAAUU,QSVEESRGGLIKPTDTLTLTCTVSGFSLSSYGEVWDRQAPGNGLEYIGAIGNSGSTYYASWAKSRSTITRNTNLNTVTLKMTSLTAADTATYFCAR,negative +AGCAGCACAGAGGTCAGATGGTTCGTTGTAGCGCATAAAGTTTATCTCTCCCATGATTCACCTATGCGTGCTACCGTGAA,MSGGDGRGHNTGAHSTSGNINGGPTGLGVGGGASDGSGWSSENNPWGGGSGSGIHWGGGSGHGNGGGNGNSGGGSGTGGNLSAVAAPVAFGFPALSTPGAGGLAVSISAGALSAAIADIMAALKGPFKFGLWGVALYGVLPSQIAKDDPNMMSKIVTSLPADDITESPVSSLPLDKATVNVNVRVVDDVKDERQNISVVSGVPMSVPVVDAKPTERPGVFTASIPGAPVLNISVNNSTPAVQTLSPGVTNNTDKDVRPAGFTQGGNTRDAVIRFPKDSGHNAVYVSVSDVLSPDQVKQRQDEENRRQQEWDATHPVEAAERNYERARAELNQANEDVARNQERQAKAVQVYNSRKSELDAANKTLADAIAEIKQFNRFAHDPMAGGHRMWQMAGLKAQRAQTDVNNKQAAFDAAAKEKSDADAALSSAMESRKKKEDKKRSAENNLNDEKNKPRKGFKDYGHDYHPAPKTENIKGLGDLKPGIPKTPKQNGGGKRKRWTGDKGRKIYEWDSQHGELEGYRASDGQHLGSFDPKTGNQLKGPDPKRNIKKYL,negative +GGAGUCUUAGGCAGCGCGUUUUCGAGCUACUCCA,MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYTFLLPEMDNCRSSSSPYVSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQDNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVLVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF,negative +GACAUCUGUAAGUAAGAUUCUAUCUGCAAAGCGGUUAGGAGGGCUCGGACUCUGAUUGCCUCCCCGCACC,MACAAARSPADQDRFICIYPAYLNNKKTIAEGRRIPISKAVENPTATEIQDVCSAVGLNVFLEKNKMYSREWNRDVQYRGRVRVQLKQEDGSLCLVQFPSRKSVMLYAAEMIPKLKTRTQKTGGADQSLQQGEGSKKGKGKKKK,negative +ACUUCAGCUCUAUUAACAGCUCAAGGACUGGCACA,MNQVTIQWDAVIALYILFSWCHGGITNINCSGHIWVEPATIFKMGMNISIYCQAAIKNCQPRKLHFYKNGIKERFQITRINKTTARLWYKNFLEPHASMYCTAECPKHFQETLICGKDISSGYPPDIPDEVTCVIYEYSGNMTCTWNAGKLTYIDTKYVVHVKSLETEEEQQYLTSSYINISTDSLQGGKKYLVWVQAANALGMEESKQLQIHLDDIVIPSAAVISRAETINATVPKTIIYWDSQTTIEKVSCEMRYKATTNQTWNVKEFDTNFTYVQQSEFYLEPNIKYVFQVRCQETGKRYWQPWSSLFFHKTPETVPQVTSKAFQHDTWNSGLTVASISTGHLTSDNRGDIGLLLGMIVFAVMLSILSLIGIFNRSFRTGIKRRILLLIPKWLYEDIPNMKNSNVVKMLQENSELMNNNSSEQVLYVDPMITEIKEIFIPEHKPTDYKKENTGPLETRDYPQNSLFDNTTVVYIPDLNTGYKPQISNFLPEGSHLSNNNEITSLTLKPPVDSLDSGNNPRLQKHPNFAFSVSSVNSLSNTIFLGELSLILNQGECSSPDIQNSVEEETTMLLENDSPSETIPEQTLLPDEFVSCLGIVNEELPSINTYFPQNILESHFNRISLLEK,negative +CCTTCATCATTAACCCGTCCACGCGC,MSSTESPVPAAAAPAEAVPASTPAPAAEQPAVGNGEQRNNADAANNTSLYVGELDPSVTEAMLFEIFSMIGTVASIRVCRDAVTRRSLGYAYVNFLNAADGERAMEQLNYSLIRNRPCRIMWSQRDPALRRTGQGNIFIKNLDAGIDNKALHDTFAAFGNILSCKVATNETGSLGYGFVHYETAEAAEAAIKHVNGMLLNDKKVYVGHHIPRKERQAKIEETRANFTNVYAKNVDPEVTDDEFEKLFTKFGKITSCVLQRDEDGKSKGFGFVNFEDHNEAQKAVDELHDSDFKGQKLFVARAQKKSEREEELRRSYEAAKNEKLAKFQGVNLYLKNIPESYDDERLREEFAPFGAITSCKIMRAPSGVSRGFGFVCYSAPEEANKAVSEMNGKMLDNRPLYVALAQRKDVRRQQLEAQIMQRNQLRLQQQAAAQGMGYPGPGMYYPQPGAFPGQPGGMVPRPRYAPAGMMPQGMPMAPYGQPGQFPAGMMPQGYRPARPPRGAPNAAGGPAPPAGARPPTGVNGAPRPAGQPVPGQPMPRGPAARPAGRPEADQPGALTAAALAKASPEEQKQMLGEAIYPKVAASQPELAGKLTGMILELPVTELLHLLEESEALDAKVNEALEVLKEYQQNDSAGAEAEANAEAPKTEA,negative +AUGACGUACCCGCACAAGCCACCACAAGUCUUAAUCGCGCCACCCUUGC,PHITDVVLDKANKTPLRQLDPSRLPDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFAKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRQSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPINRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDTASEATRPATLNRFSALQQTLPAENTDNRRVVQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRTRTPATKRSFSKEVEERSRERPSQPEGLRKAASLTEDRGRDPVKREATLPPVSPPKAALSVDEVEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRLGIESTLERSTIAREHMGRLLHQLLCAGHLSTAQYYQGLYETLELAEDMEIDIPHVWLYLAELITPILQEDGVPMGELFREITKPLRPMGKATSLLLEILGLLCKSMGPKKVGMLWREAGLSWREFLAEGQDVGSFVAEKKVEYTLGEESEAPGQRTLAFEELRRQLEKLLKDGGSNQRVFDWIDANLNEQQIASNTLVRALMTTVCYSAIIFETPLRVDVQVLKVRARLLQKYLCDEQKELQALYALQALVVTLEQPANLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFNWLREAEDEESDHN,negative +CACUGCAGUGUAUGCAAAGCUU,MLNQLDNLTERVRGSNKLVDRWLHVRKHLLVAYYNLVGIKPGKESYMRLNEKALDDFCQSLVDYLSAGHFSIYERILHKLEGNGQLARAAKIWPQLEANTQQIMDYYDSSLETAIDHDNYLEFQQVLSDIGEALEARFVLEDKLILLVLDAARVKHPA,negative +TACTGCATGCACACCACTTCAACTA,QELLCAASLISDRWVLTAAHCLLYPPWDKNFTVNDILVRIGKYARSRYERNMEKISTLEKIIIHPGYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDKQIVTSLLQAGHKGRVTGWGNLKEMWTVNMNEVQPSVLQMVNLPLVERPICKASTGIRVTDNMFCAGYKPEEGKRGDACEGDSGGPFVMKNPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIRKMVDRFG,negative +GATTGAAAGGTCTGTTTTTGGGGTTGGTTTGGGTCAATA,MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP,negative +GGGAGAGAGGAAGAGGGAUGGGCGACCGAACGUGCCCUUCAAAGCCGUUCACUAACCAGUGGCAUAACCCAGAGGUCGAUAGUACUGGUCCCCCC,MASNFTQFVLVDNGGTGDVTVAPSNFANGVAEWISSNSRSQAYKVTCSVRQSSAQNRKYTIKVEVPKVATQTVGGVELPVAAWRSYLNMELTIPIFATNSDCELIVKAMQGLLKDGNPIPSAIAANSGIY,negative +TATTAGTAATCATATTAGTAATCA,MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA,negative +GGACCUUUGUACCCCAGAUGAUAGUGAGGCGCGGCUUGAUGGGUACAAAUGGCAG,MAITKINDCFELLSMVTYADKLKSLIKKEFSISFEEFAVLTYISENKEKEYYLKDIINHLNYKQPQVVKAVKILSQEDYFDKKRNEHDERTVLILVNAQQRKKIESLLSRVNKRITEANNEIEL,negative +GCAGAACCACCCCCUUCCAUCACUCCAGCC,MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC,negative +CACUCAGCGCCCUGCGAAACGUUGCCGCCUCCCAACGUCU,ASFTCLAIWALASAGVVPLVLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAAFFFVPVIISTVCYVSIIRCLSSSAVANRSKK,negative +UAAUACGACUCACUAUAGGGAGGACGAUGCGGAAUUGAGGGACCACGCGCUGCUUGUUGUGAUAAGCAGUUUGUCGUGAUGGUCGGGCGAGUCGUCUG,MVDREQLVQKARLAEQAERYDDMAAAMKNVTELNEPLSNEERNLLSVAYKNVVGARRSSWRVISSIEQKTSADGNEKKIEMVRAYREKIEKELEAVCQDVLSLLDNYLIKNCSETQYESKVFYLKMKGDYYRYLAEVATGEKRATVVESSEKAYSEAHEISKEHMQPTHPIRLGLALNYSVFYYEIQNAPEQACHLAKTAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDQQDDDGGEGNN,negative +TGACACAAAGACAGACAGGCTATCCAAGAACCCTCTTACTCTGTGAGACGACGCACCGGTCGCAGGTTTTGTCTCACAGACGCTAAAAATACAGACATGCACCAATGAACAATGAGTTCGACCGTGTTCTTGAGTTTTATGGCCGATGTGGTAAGTACTTCTACTGTATCTTCGCGTACCTTAGGTTTAACGTTCTCTTTTTCGGAATGTGCTCGCCCGCGGCATCCGACGTCCCTTTGGGGGGTAGGTGCAACGGGAATCTTGAGGGATCATT,XQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGSTGSPGPGYGYSNYGFPPYGGITFHPGVTKSNAGVTHGTINTKFKNGPKDCAKSDDEESLTLPEKETEGEGPSLPMACTKTEPIALASTMEDKEQDMGFQDNLFLEKALQLARRHANALFDYAVTGDVKMLLAVQRHLTAVQDENGDSVLHLAIIHLHAQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRVGADLSLLDRWGNSVLHLAAKEGHDRILSILLKSRKAAPLIDHPNGEGLNAIHIAVMSNSLPCLLLLVAAGAEVNAQEQKSGRTALHLAVEYDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWEKAGEDEGVVPGTTPLDMAANWQVFDILNGKPYEPVFTSDDILPQGDMKQLTEDTRLQLCKLLEIPDPDKNWATLAQKLGLGILNNAFRLSPAPSKTLMDNYEMNSGIVTASVTVVWRHPSANSALQSLLLETAHCYL,negative +GGGGCCACCAACGACAUUUAUCGAAUUGAUAACCUUACGCGAGAGCGUAGUUCGUUGAUAUAAAUAGUGCCCAUGGAUC,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +TGACTGCCGCACCGACCATTCACGGTATTTGGCACGGCC,MGCRRTREGPSKAMIFPWKCQSTQRDLWNIFKLWGWTMLCCDFLAHHGTDCWTYHYSEKPMNWQRARRFCRDNYTDLVAIQNKAEIEYLEKTLPFSRSYYWIGIRKIGGIWTWVGTNKSLTEEAENWGDGEPNNKKNKEDCVEIYIKRNKDAGKWNDDACHKLKAALCYTASCQPWSCSGHGECVEIINNYTCNCDVGYYGPQCQFVIQCEPLEAPELGTMDCTHPLGNFSFSSQCAFSCSEGTNLTGIEETTCGPFGNWSSPEPTCQVIQCEPLSAPDLGIMNCSHPLASFSFTSACTFICSEGTELIGKKKTICESSGIWSNPSPICQKLDKSFSMIKEGDYNPLFIPVAVMVTAFSGLAFIIWLARRLKKGM,negative +AGCGCGCACCTACTGTGATGCAGAAGTCACAGCAAGGCCC,MGVLLTQRTLLSLVLALLFPSMASMAAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQGLDVPKLREHCRERPGAFPSEETLRGLGRRGFLQTLNATLGCVLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILGLRNNIYCMAQLLDNSDTAEPTKAGRGASQPPTPTPASDAFQRKLEGCRFLHGYHRFMHSVGRVFSKWGESPNRSRRHSPHQALRKGVRRTRPSRKGKRLMTRGQLPR,negative +AGATACGCTCGTGTTGCTCGATAGC,MKKTLIALAIAASAASGMAHAWMTGDFNGSVDIGGSITADDYRQKWEWKVGTGLNGFGNVLNDLTNGGTKLTITVTGNKPILLGRTKEAFATPVTGGVDGIPHIAFTDYEGASVVLRNPDGETNKKGLAYFVLPMKNAEGTKVGSVKVNASYAGVLGRGGVTSADGELLSLFADGLSSIFYGGLPRGSELSAGSAAAARTKLFGSLSRNDILGQIQRVNANITSLVDVAGSYRENMEYTDGTVVSAAYALGIANGQTIEATFNQAVTTSTQWSAPLNVAITYY,negative +TCCCTACGGCGCTAACCAGTGCTAGCCACTGCGGGGTTCCCTTGTTGCCACCGTGCTACAAC,MDSTNYISKLFEYAQRQGQISDIKFEEVGTDGPDHLKTFTLRVVIKGHAYPNGVGKTKKEAKRNAAKHALIGMMETTEQKDASVSCPPSPAPSPAPPVRAVISQPKYVSWLNEHSQKNKLSLKALEGARVGPNNTSQCCRYVVGEKEYPEGFGNTKKEAKEEAAMQVYLELCGGSQTTGTVDENCNGTTGKHKEELNGKVVVLSEKVEHMNMSPAQNVPEQYSFITTEETNFIGILNHYCQKTKRFLDFKLVEKSGPSHNPQFVYKVLIDKREYPDGLGKTAKEAKQQAAQLAWSALQEQSDWNSQVSCRSTVSEEGGLSSLTPSSTWESQDATPSSLSIAGSTSESIIFSDSVNVSSPKDESPVNVKPKIRLAANFQMSPVKTKQEGPNLKGNDLGTLSSGRTSNQPVISRFSSEFDSIENIGKGGFGHVYKARRKLEQKYFAVKIVRSKGKAKREVGALADLQHPNIVRYYTAWLEDTAYRCDTASESDTTSDSGSSSSSEFLYIQMELCDKRTLKVWIDERNAHRKPKRREESLSITQQIVNGVEYIHSKKLLHRDLKPANIMFGMSDGEGKGEVKIGDFGLVTAEDNDNDENLLERTKKTGTVSYMAPEQRNQTSYDRKVDIFALGLIYFEPLWDLSGMEKAKVWNDVRSQRFPQQFNSQFTLENKVIESLLCANPEERPDARQLKTKLNECSRVLTRVHNIHQDNRTI,negative +GUUUAUAUAUACACAGGUUAAGCGUAACUUCGCUGGACAGCAAGAAUCCU,MSSTESPVPAAAAPAEAVPASTPAPAAEQPAVGNGEQRNNADAANNTSLYVGELDPSVTEAMLFEIFSMIGTVASIRVCRDAVTRRSLGYAYVNFLNAADGERAMEQLNYSLIRNRPCRIMWSQRDPALRRTGQGNIFIKNLDAGIDNKALHDTFAAFGNILSCKVATNETGSLGYGFVHYETAEAAEAAIKHVNGMLLNDKKVYVGHHIPRKERQAKIEETRANFTNVYAKNVDPEVTDDEFEKLFTKFGKITSCVLQRDEDGKSKGFGFVNFEDHNEAQKAVDELHDSDFKGQKLFVARAQKKSEREEELRRSYEAAKNEKLAKFQGVNLYLKNIPESYDDERLREEFAPFGAITSCKIMRAPSGVSRGFGFVCYSAPEEANKAVSEMNGKMLDNRPLYVALAQRKDVRRQQLEAQIMQRNQLRLQQQAAAQGMGYPGPGMYYPQPGAFPGQPGGMVPRPRYAPAGMMPQGMPMAPYGQPGQFPAGMMPQGYRPARPPRGAPNAAGGPAPPAGARPPTGVNGAPRPAGQPVPGQPMPRGPAARPAGRPEADQPGALTAAALAKASPEEQKQMLGEAIYPKVAASQPELAGKLTGMILELPVTELLHLLEESEALDAKVNEALEVLKEYQQNDSAGAEAEANAEAPKTEA,negative +ACAAAGCUGGAGUACUUACCGAACAUCCGUCUAACCCCU,MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPGPHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR,negative +CTCCTCTGACTGTAACCACGGTATAAACCTAGTACGAAGCGTATCTTTACGGGTGCCTGAGCATAGGTAGTCCAGAAGCC,MDKFWWHAAWGLCLVPLSLAQIDLNITCRFAGVFHVEKNGRYSISRTEAADLCKAFNSTLPTMAQMEKALSIGFETCRYGFIEGHVVIPRIHPNSICAANNTGVYILTSNTSQYDTYCFNASAPPEEDCTSVTDLPNAFDGPITITIVNRDGTRYVQKGEYRTNPEDIYPSNPTDDDVSSGSSSERSSTSGGYIFYTFSTVHPIPDEDSPWITDSTDRIPATTLMSTSATATETATKRQETWDWFSWLFLPSESKNHLHTTTQMAGTSSNTISAGWEPNEENEDERDRHLSFSGSGIDDDEDFISSTISTTPRAFDHTKQNQDWTQWNPSHSNPEVLLQTTTRMTDVDRNGTTAYEGNWNPEAHPPLIHHEHHEEEETPHSTSTIQATPSSTTEETATQKEQWFGNRWHEGYRQTPKEDSHSTTGTAAASAHTSHPMQGRTTPSPEDSSWTDFFNPISHPMGRGHQAGRRMDMDSSHSITLQPTANPNTGLVEDLDRTGPLSMTTQQSNSQSFSTSHEGLEEDKDHPTTSTLTSSNRNDVTGGRRDPNHSEGSTTLLEGYTSHYPHTKESRTFIPVTSAKTGSFGVTAVTVGDSNSNVNRSLSGDQDTFHPSGGSHTTHGSESDGHSHGSQEGGANTTSGPIRTPQIPEWLIILASLLALALILAVCIAVNSRRRCGQKKKLVINSGNGAVEDRKPSGLNGEASKSQEMVHLVNKESSETPDQFMTADETRNLQNVDMKIGV,negative +AATGATAAACCACTGGTGAATCGCTCAAGTCAGTAGTAGG,MAGPQALAFGLLLAVVTATLAAAQRDCVCDNYKLATSCSLNEYGECQCTSYGTQNTVICSKLASKCLAMKAEMTHSKSGRRIKPEGAIQNNDGLYDPDCDEQGLFKAKQCNGTATCWCVNTAGVRRTDKDTEITCSERVRTYWIIIELKHKERESPYDHQSLQTALQEAFTSRYKLNQKFIKNIMYENNVITIDLMQNSSQKTQDDVDIADVAYYFEKDVKGESLFHSSKSMDLRVNGEPLDLDPGQTLIYYVDEKAPEFSMQGLTAGIIAVIVVVSLAVIAGIVVLVISTRKKSAKYEKAEIKEMGEIHRELNA,negative +GCAAUGGUACGGUACUUCCUUUGGAAGAUAGCUGGAGAACUAACCAAAAGUGCACGCUACUUUGCUAA,MEDDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKEEIAEVANEIESLGSTEERKNMQRNKQVAMGRKKFNMDPKKGIQFLIENGLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERDEFSIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNTGVFQSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIKNEPFKIPVWFFLQNLYESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEDWIKCIKAAISRDPFYEMLAARKKKVSSTKRH,negative +GACAUCUGUAAGUAAGAUUCUAUCUGCAAAGCGGUUAGGGGGGCUCGGACUCUGAUUGCCUCCCCGCACC,MGCRRTREGPSKAMIFPWKCQSTQRDLWNIFKLWGWTMLCCDFLAHHGTDCWTYHYSEKPMNWQRARRFCRDNYTDLVAIQNKAEIEYLEKTLPFSRSYYWIGIRKIGGIWTWVGTNKSLTEEAENWGDGEPNNKKNKEDCVEIYIKRNKDAGKWNDDACHKLKAALCYTASCQPWSCSGHGECVEIINNYTCNCDVGYYGPQCQFVIQCEPLEAPELGTMDCTHPLGNFSFSSQCAFSCSEGTNLTGIEETTCGPFGNWSSPEPTCQVIQCEPLSAPDLGIMNCSHPLASFSFTSACTFICSEGTELIGKKKTICESSGIWSNPSPICQKLDKSFSMIKEGDYNPLFIPVAVMVTAFSGLAFIIWLARRLKKGM,negative +GCAGCAGGGAGAGTTGTGTGAGGGAAGTGGTCGGTAGGTG,MSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEMLDRHHTHFCPLEGESWQDFLRNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAFLCQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERETPTTDSMPPLLRQAIELFDHQGAEPAFLFGLELIICGLEKQLKCESGS,negative +GGAATGAGTGCCCTGCAAGCGAGGGCTAGC,PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGKISKIGPENPYNTPVFAIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDESFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPXRXKNPEMVIYQYMDDLYVGSDLEIGQHRAKIEELRSHLLSWGFTTPDKKHQKEPPFLWMGYELHPDSWTVQPIELPEKDSWTVNE,negative +GAAGCUUACAAGAAGGACAGCACGAAUAAAACCUGCGUAAAUCCGCCCCAUUUGUGUAAGGGUAGUAAAUCGAAUUCCGCUCA,PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGKISKIGPENPYNTPVFAIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDESFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPXRXKNPEMVIYQYMDDLYVGSDLEIGQHRAKIEELRSHLLSWGFTTPDKKHQKEPPFLWMGYELHPDSWTVQPIELPEKDSWTVNE,negative +UGUAGUUUCCCUGUAUGC,MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYTFLLPEMDNCRSSSSPYVSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQDNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVLVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF,negative +CCACCACCACAACAAAACTCCAC,MLNQLDNLTERVRGSNKLVDRWLHVRKHLLVAYYNLVGIKPGKESYMRLNEKALDDFCQSLVDYLSAGHFSIYERILHKLEGNGQLARAAKIWPQLEANTQQIMDYYDSSLETAIDHDNYLEFQQVLSDIGEALEARFVLEDKLILLVLDAARVKHPA,negative +CCCGGUUACCGUGUUUGUUCUGCUAGAUUUUGGUU,GRQVDIDGEDYQRRDSIAQLLEDWGLIVIEDSAREDLFGLTNNFRVISFKQKDDWTLKAKYTIGN,negative +AAGCCGGAUGCACGAAUAUUGAGGUAAGCG,MTRCTADNSLTNPAYRRRTMATGEMKEFLGIKGTEPTDFGINSDAQDLPSPSRQASTRRMSIGESIDGKINDWEEPRLDIEGFVVDYFTHRIRQNGMEWFGAPGLPCGVQPEHEMMRVMGTIFEKKHAENFETFCEQLLAVPRISFSLYQDVVRTVGNAQTDQCPMSYGRLIGLISFGGFVAAKMMESVELQGQVRNLFVYTSLFIKTRIRNNWKEHNRSWDDFMTLGKQMKEDYERAEAEKVGRRKQNRRWSMIGAGVTAGAIGIVGVVVCGRMMFSLK,negative +GGGAGAGAGGAAGAGGGAUGGGCGACCGAACGUGCCCUUCAAAGCCGUUCACUAACCAGUGGCAUAACCCAGAGGUCGAUAGUACUGGUCCCCCC,MKPGGNTIVIWMYAVATWLCFGSTSGWSFTLEDNNIFPKQYPIINFTTAGATVQSYTNFIRAVRGRLTTGADVRHEIPVLPNRVGLPINQRFILVELSNHAELSVTLALDVTNAYVVGYRAGNSAYFFHPDNQEDAEAITHLFTDVQNRYTFAFGGNYDRLEQLAGNLRENIELGNGPLEEAISALYYYSTGGTQLPTLARSFIICIQMISEAARFQYIEGEMRTRIRYNRRSAPDPSVITLENSWGRLSTAIQESNQGAFASPIQLQRRNGSKFSVYDVSILIPIIALMVYRCAPPPSSQFSLLIRPVVPNFNADVCMDPEPIVRIVGRNGLCVDVRDGRFHNGNAIQLWPCKSNTDANQLWTLKRDNTIRSNGKCLTTYGYSPGVYVMIYDCNTAATDATRWQIWDNGTIINPRSSLVLAATSGNSGTTLTVQTNIYAVSQGWLPTNNTQPFVTTIVGLYGLCLQANSGQVWIEDCSSEKAEQQWALYADGSIRPQQNRDNCLTSDSNIRETVVKILSCGPASSGQRWMFKNDGTILNLYSGLVLDVRASDPSLKQIILYPLHGDPNQIWLPLF,negative +ATTGACCGCTGTGTGACGCAACACTCAAT,ASFTCLAIWALASAGVVPLVLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAAFFFVPVIISTVCYVSIIRCLSSSAVANRSKK,negative +TAGTGATGTTCGTGGCGAATGATACACTTA,MDHLNEATQGKEHSEMSNNVSDPKGPPAKIARLEQNGSPLGRGRLGSTGAKMQGVPLKHSGHLMKTNLRKGTMLPVFCVVEHYENAIEYDCKEEHAEFVLVRKDMLFNQLIEMALLSLGYSHSSAAQAKGLIQVGKWNPVPLSYVTDAPDATVADMLQDVYHVVTLKIQLHSCPKLEDLPPEQWSHTTVRNALKDLLKDMNQSSLAKECPLSQSMISSIVNSTYYANVSAAKCQEFGRWYKHFKKTKDMMVEMDSLSELSQQGANHVNFGQQPVPGNTAEQPPSPAQLSHGSQPSVRTPLPNLHPGLVSTPISPQLVNQQLVMAQLLNQQYAVNRLLAQQSLNQQYLNHPPPVSRSMNKPLEQQVSTNTEVSSEIYQWVRDELKRAGISQAVFARVAFNRTQGLLSEILRKEEDPKTASQSLLVNLRAMQNFLQLPEAERDRIYQDERERSLNAASAMGPAPLISTPPSRPPQVKTATIATERNGKPENNTMNINASIYDEIQQEMKRAKVSQALFAKVAATKSQGWLCELLRWKEDPSPENRTLWENLSMIRRFLSLPQPERDAIYEQESNAVHHHGDRPPHIIHVPAEQIQQQQQQQQQQQQQQQAPPPPQPQQQPQTGPRLPPRQPTVASPAESDEENRQKTRPRTKISVEALGILQSFIQDVGLYPDEEAIQTLSAQLDLPKYTIIKFFQNQRYYLKHHGKLKDNSGLEVDVAEYKEEELLKDLEESVQDKNTNTLFSVKLEEELSVEGNTDINTDLKD,negative +GGGGTTCCACCTTCACTGGGCGCGCCCAGTGAAGGTGGAACCCC,MKEFEVKVASTAFVLVLFSLTINQILASETSTKFRSPVPAPTVPDWNHLPNEGNEENVVSAPKQDGASGGQKPYWTKREKMMKRLHAEPAGNTVRFRCAVDGNPKPQVLWYKNDLIVQKNDRVGGYKYRNQVLILESVVLSDKGNYMCVARNEYGSINHTYQLDVQERSASKPILAEGLPQNKSAYIGDDVTFKCKVYSDAHPHIQWLKSINNHNNAAPNYTVLKAAGVNTTDLDMEVLILKNVSFEEAGEYTCLAGNSIGISHQSAWLSVLPVPPPTTDTITKGIPNETNIIIYVMCGVLVILFGLAVVLVLYYHCYNGKDPPMLVRIENPDNIPPMTKIEHPTMLFGNTQAWQRMCMPMQEPFEFNIQLDLQWELQREDITLVERLDEGFFGQVFKADLVTCNNTRKEKMVCAVKMLKGNRNEKDVLDLLTEMDQMKRVGKHKNIINLLGVCTQNGPLWLVIEYAAQGNLRDYLRRNRPQNTLCNLVLPSEGRNPDDELPVPHGDTLTQKDIVSFAFQVARGLEFLAQKKCIHRDLAARNVLVTEELVMKIADFGLARDIRSCDYYRKHTRGHLPYKWMALEAMSDNIFTHATDVWSFGVLLWEIFSLAGSPYPGIKTHELVKFLRSGERLDKPQYASQEMYRLMRDCWEEDPSKRPNFRTLVEDLDRMLAESSTEVYIDFAAGCEAEYSESSEDESESQNSDEEDDDSVFERMRQIDSLSNGNIPFNEEDSSNSDPYVAPLLQNEENVLQNEHARLRSEA,negative +CGAATACCTGGAGGAACACGGGAAAAGATCACTGAAGCCA,MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICEVEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASSIVYKKEGEQVEFSFPLAFTVEKLTGSGELWWQAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLPQALPQYAGSGNLTLALEAKTGKLHQEVNLVVMRATQLQKNLTCEVWGPTSPKLMLSLKLENKEAKVSKREKAVWVLNPEAGMWQCLLSDSGQVLLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQAERMSQIKRLLSEKKTCQCPHRFQKTCSPI,negative +CAAUCCAUUCAUCUCUCGAAUGAGGAAGUAGCCCAAGAGGAGGAGGAGGAUGAGC,MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPGPHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR,negative +GUUCCAGGCGCGUUAGCAAAACCGCGGAUC,MAITKINDCFELLSMVTYADKLKSLIKKEFSISFEEFAVLTYISENKEKEYYLKDIINHLNYKQPQVVKAVKILSQEDYFDKKRNEHDERTVLILVNAQQRKKIESLLSRVNKRITEANNEIEL,negative +CGTATAGGTCCCCTGCCGCTAAACAGCGCCGCGGTA,MKKRKVLIPLMALSTILVSSTGNLEVIQAEVKQENRLLNESESSSQGLLGYYFSDLNFQAPMVVTSSTTGDLSIPSSELENIPSENQYFQSAIWSGFIKVKKSDEYTFATSADNHVTMWVDDQEVINKASNSNKIRLEKGRLYQIKIQYQRENPTEKGLDFKLYWTDSQNKKEVISSDNLQLPELKQKSSNSRKKRSTSAGPTVPDRDNDGIPDSLEVEGYTVDVKNKRTFLSPWISNIHEKKGLTKYKSSPEKWSTASDPYSDFEKVTGRIDKNVSPEARHPLVAAYPIVHVDMENIILSKNEDQSTQNTDSQTRTISKNTSTSRTHTSEVHGNAEVHASFFDIGGSVSAGFSNSNSSTVAIDHSLSLAGERTWAETMGLNTADTARLNANIRYVNTGTAPIYNVLPTTSLVLGKNQTLATIKAKENQLSQILAPNNYYPSKNLAPIALNAQDDFSSTPITMNYNQFLELEKTKQLRLDTDQVYGNIATYNFENGRVRVDTGSNWSEVLPQIQETTARIIFNGKDLNLVERRIAAVNPSDPLETTKPDMTLKEALKIAFGFNEPNGNLQYQGKDITEFDFNFDQQTSQNIKNQLAELNATNIYTVLDKIKLNAKMNILIRDKRFHYDRNNIAVGADESVVKEAHREVINSSTEGLLLNIDKDIRKILSGYIVEIEDTEGLKEVINDRYDMLNISSLRQDGKTFIDFKKYNDKLPLYISNPNYKVNVYAVTKENTIINPSENGDTSTNGIKKILIFSKKGYEIG,negative +CAGCUAGAGGCAAAGUGGUCUCGACGUAGGGGGACCUGCUCGCUG,MGVLLTQRTLLSLVLALLFPSMASMAAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQGLDVPKLREHCRERPGAFPSEETLRGLGRRGFLQTLNATLGCVLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILGLRNNIYCMAQLLDNSDTAEPTKAGRGASQPPTPTPASDAFQRKLEGCRFLHGYHRFMHSVGRVFSKWGESPNRSRRHSPHQALRKGVRRTRPSRKGKRLMTRGQLPR,negative +ATTGACCGCTGTGTGACGCAACACTCAAT,MSSTESPVPAAAAPAEAVPASTPAPAAEQPAVGNGEQRNNADAANNTSLYVGELDPSVTEAMLFEIFSMIGTVASIRVCRDAVTRRSLGYAYVNFLNAADGERAMEQLNYSLIRNRPCRIMWSQRDPALRRTGQGNIFIKNLDAGIDNKALHDTFAAFGNILSCKVATNETGSLGYGFVHYETAEAAEAAIKHVNGMLLNDKKVYVGHHIPRKERQAKIEETRANFTNVYAKNVDPEVTDDEFEKLFTKFGKITSCVLQRDEDGKSKGFGFVNFEDHNEAQKAVDELHDSDFKGQKLFVARAQKKSEREEELRRSYEAAKNEKLAKFQGVNLYLKNIPESYDDERLREEFAPFGAITSCKIMRAPSGVSRGFGFVCYSAPEEANKAVSEMNGKMLDNRPLYVALAQRKDVRRQQLEAQIMQRNQLRLQQQAAAQGMGYPGPGMYYPQPGAFPGQPGGMVPRPRYAPAGMMPQGMPMAPYGQPGQFPAGMMPQGYRPARPPRGAPNAAGGPAPPAGARPPTGVNGAPRPAGQPVPGQPMPRGPAARPAGRPEADQPGALTAAALAKASPEEQKQMLGEAIYPKVAASQPELAGKLTGMILELPVTELLHLLEESEALDAKVNEALEVLKEYQQNDSAGAEAEANAEAPKTEA,negative +AAGACCACACAUAAGAAACAGGGAACAGCGUUCAA,QSVEESRGGLIKPTDTLTLTCTVSGFSLSSYGEVWDRQAPGNGLEYIGAIGNSGSTYYASWAKSRSTITRNTNLNTVTLKMTSLTAADTATYFCAR,negative +GGAGUCUUAGGCAGCGCGUUUUCGAGCUACUCCA,MHGDTPTLHEYMLDLQPETTDLYCYEQLNDSSEEEDEIDGPAGQAEPDRAHYNIVTFCCKCDSTLRLCVQSTHVDIRTLEDLLMGTLGIVCPICSQKP,negative +ACGCGCTAGGATCAAAGCTGCACTGAAGTG,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +GGGCGAAUUCGAGCCUCAAGUGCCAUGAGUGAAAUAAAACCAUCCGGAACUAAGACUGCGCUGUUACUCGGCGGAUCCUCU,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,negative +CAGGAUGAACAAGCAGGACGUGAAAUGAAC,MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP,negative +GGGACACAAUGGACGUCCGUAGAAACGCGUUAAGGUGAAAGUUUGAGGGCUCCUCAUAACGGCCGACAUGAGAG,QELLCAASLISDRWVLTAAHCLLYPPWDKNFTVNDILVRIGKYARSRYERNMEKISTLEKIIIHPGYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDKQIVTSLLQAGHKGRVTGWGNLKEMWTVNMNEVQPSVLQMVNLPLVERPICKASTGIRVTDNMFCAGYKPEEGKRGDACEGDSGGPFVMKNPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIRKMVDRFG,negative +CGGAATTCCGAGCGTGGGCGTGGTCATACCGCGCCTATCGAACTCGCCACTCGCGTGCAGCTCTGTGTAGGTACGCCCACGCTCGAG,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +ATATTCGCGATTATT,MPSNQEARLFLAVLVLAQVLPILVDSAAEKGFKQAFWQPLCQVSEELDDQPKGALFTLQAAASKIQKMRDAALRASIYAEINHGTNRAKAAVIVANHYAMKADSGLEALKQTLSSQEVTATATASYLKGRIDEYLNLLLQTKESGTSGCMMDTSGTNTVTKAGGTIGGVPCKLQLSPIQPKRPAATYLGKAGYVGLTRQADAANNFHDNDAECRLASGHNTNGLGKSGQLSAAVTMAAGYVTVANSQTAVTVQALDALQEASGAAHQPWIDAWKAKKALTGAETAEFRNETAGIAGKTGVTKLVEEALLKKKDSEASEIQTELKKYFSGHENEQWTAIEKLISEQPVAQNLVGDNQPTKLGELEGNAKLTTILAYYRMETAGKFEVLTQKHKPAESQQQAAETEGSCNKKDQNECKSPCKWHNDAENKKCTLDKEEAKKVADETAKDGKTGNTNTTGSSNSFVISKTPLWLAVLLF,negative +AGCAGCACAGAGGTCAGATGGGTAGGTAGCCGTGCCGGTTGTGCCATTGATTGTACAGTTCCTATGCGTGCTACCGTGAA,MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP,negative +TCCCTACGGCGCTAACTCCCGATAGGAGGCCCGTGGCCGTGTTATCGCCACCGTGCTACAAC,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,negative +GCAGUUAACCAAGCCUGCAUACUGGAUAGACGGCUUAUUUGACUGAAUGCCUCCCGAAAGGUGCAGUU,DPAFEGPYFQSHNAGRHREAAEGLFAAGRAYYCDCTREQLKERTGSEHLGYDGFCRERGLGYAAGRALRFRTPDEGETVVADLVRGEPAFPNSAIEDFVIARGDGSPVFLLANVVDDLDEGITQVIRGEEHLSNTPKQQLLWEALGAGPPVWAHLPVIVNEKRQKLSKRRDKVALEDYLGEGFLPEALVNYLMLLGWGPGGDREIMPYEELERLFRIEDVNTAPAFFDVKKLTAFNGEYLRALAPAQFAAACVPWLVAPYAPWRPEAFDKDVFEAAAPLARTRLTRLSEITGYVDFLFLDEPVDDEVSWHKAMKEGAADILTDVRAGLAAVTGWTAEELKGVLLAVGEQHGLKLGKAQAPVRVAVTGRTVGLPLFRVPGTGSAGSGCWPGWTPQIRRLAGRGAPG,negative +GGGCCGTTCGAACCGAGCATGGATCGAGGATGGGAACACCCAGTAGGAGGATGGGCATGGCCGGACCCAAAATTAGCAGTGGGACAGTACTCAGGTCATCCTAGG,PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGKISKIGPENPYNTPVFAIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDESFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPXRXKNPEMVIYQYMDDLYVGSDLEIGQHRAKIEELRSHLLSWGFTTPDKKHQKEPPFLWMGYELHPDSWTVQPIELPEKDSWTVNE,negative +GCGAGCAUCAGCCGC,EFPPSTFYRVTLYGLYKGELLDPVFAEAITEAEPEVEHITVSDITPHSFKVTWTAPEAVFDSFALKVLDSSGLGRPHQISVSGDKRTEAVTGLNEDTDYEIELFGIILGRKFQPIFTVARTGLGTRKGIRFSDVTDTSATVHWTMPHTRVDNYRVIYVPIQGGSPLTLRVDGGESQAMLSNLTPGVTYQVTVIAVKGLEESEPGSERVTTALDKPRGLTAVNISDTEALLLWQPSIATVDGYVITYSADSVAPVMERVSGNTVEFEMSSLTPATLYTVKVYAFRDTAKSAATSTDFTTDVDAPQNLAASNIQTETAMLTWKPPRADISGYILSFESADGVVKEVVLSPTATFYSMSHLTASTEYTVKLQAIAGPKRSRVISTVFLTIGVLYKHPKDCSQALLNGDTTSGFYTIYLRGDESQPLQVYCDMTTDGGGWIVFVRRQSGKVEFFRNWKNYTAGFGDLNDEFWLGLSNLHKITSFGQYELRVDLRDKGESAYAQYDKFSISEPRARYKVHVGGYSGTAGDSMTYHHGRPFSTYDNDNDIAVTNCALSYKGAFWYKNCHRVNIMGRYGDNSHSKGVNWFHWKGHEHSVEFAEMKIRPANFRNFEGRKKRS,negative +CGCGGATCCTGCAGCTCGAGCTCCAAGTTATTGTTTATGCTTTGCAGGGACTCTAGAAGCTTGTCGAC,MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICEVEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASSIVYKKEGEQVEFSFPLAFTVEKLTGSGELWWQAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLPQALPQYAGSGNLTLALEAKTGKLHQEVNLVVMRATQLQKNLTCEVWGPTSPKLMLSLKLENKEAKVSKREKAVWVLNPEAGMWQCLLSDSGQVLLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQAERMSQIKRLLSEKKTCQCPHRFQKTCSPI,negative +CTTCTGCCCGCCTCCTTCCCGCACTTGCAAACCTTCATGGTCTCGTGCTTGAGTGGTTGGAGACGAGATAGGCGGACACT,MVKSHIGSWILVLFVAMWSDVGLCKKRPKPGGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGSHSQWNKPSKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGNDYEDRYYRENMYRYPNQVYYRPVDRYSNQNNFVHDCVNITVKQHTVTTTTKGENFTETDIKIMERVVEQMCITQYQRESQAYYQRGASVILFSSPPVILLISFLIFLIVG,negative +GGCTATAGCACATGGGTAAAACGAC,MLSWGYFLFLLPTLPGAQSQVQLVESGGDVRKPGDSLRLSCKGSGFTFSNYWLGWVRQAPGKALNGSLPLTPLAAAPTYIPGVSGRFTISRDNARALLHLDMSDLRPEDTGRYHCER,negative +GGACCUUUGUACCCCAGAUGAUGCUUUAUCAGGCGGAUGGGUACAAAUGGCAG,MVKSHIGSWILVLFVAMWSDVGLCKKRPKPGGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGSHSQWNKPSKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGNDYEDRYYRENMYRYPNQVYYRPVDRYSNQNNFVHDCVNITVKQHTVTTTTKGENFTETDIKIMERVVEQMCITQYQRESQAYYQRGASVILFSSPPVILLISFLIFLIVG,negative +ACACCCACCGCAGGCAGACGCAACGCCTCGGAGACTAGCC,MSMSPKHTTPFSVSDILSPLEESYKKVGMEGGGLGAPLAAYRQGQAAPPAAAMQQHAVGHHGAVTAAYHMTAAGVPQLSHSAVGGYCNGNLGNMSELPPYQDTMRNSASGPGWYGANPDPRFPAISRFMGPASGMNMSGMGGLGSLGDVSKNMAPLPSAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGGGGGGGAGCPQQQQAQQQSPRRVAVPVLVKDGKPCQAGAPAPGAGSLQGHAQQQAQQQAQAAQAAAAAISVGSGGPGLGAHPGHQPGSAGQSPDLAHHAASPAALQGQVSSLSHLNSSGSDYGTMSCSTLLYGRTW,negative +GUAUUCUCGGUGGUUUAAUCAGAGUAGAGGAGGCUGACUCCUUUGGUUGGACGACGGUGGAGGUUCUUCUUG,MKPGGNTIVIWMYAVATWLCFGSTSGWSFTLEDNNIFPKQYPIINFTTAGATVQSYTNFIRAVRGRLTTGADVRHEIPVLPNRVGLPINQRFILVELSNHAELSVTLALDVTNAYVVGYRAGNSAYFFHPDNQEDAEAITHLFTDVQNRYTFAFGGNYDRLEQLAGNLRENIELGNGPLEEAISALYYYSTGGTQLPTLARSFIICIQMISEAARFQYIEGEMRTRIRYNRRSAPDPSVITLENSWGRLSTAIQESNQGAFASPIQLQRRNGSKFSVYDVSILIPIIALMVYRCAPPPSSQFSLLIRPVVPNFNADVCMDPEPIVRIVGRNGLCVDVRDGRFHNGNAIQLWPCKSNTDANQLWTLKRDNTIRSNGKCLTTYGYSPGVYVMIYDCNTAATDATRWQIWDNGTIINPRSSLVLAATSGNSGTTLTVQTNIYAVSQGWLPTNNTQPFVTTIVGLYGLCLQANSGQVWIEDCSSEKAEQQWALYADGSIRPQQNRDNCLTSDSNIRETVVKILSCGPASSGQRWMFKNDGTILNLYSGLVLDVRASDPSLKQIILYPLHGDPNQIWLPLF,negative +UCCCCCGCGCACAUUCCCGCCAACCUGCAA,MPEEWVRIFGEAGITQFEQQRNPRLCLSVLNILSKSEHPQEKFMFVPYEQSALPVTDNSPFGDTSITHNYADHHFKASTPENEGSSFYSRVPGPCTVGVRSSSLSSGRGSSEGVGSRSGSGSGGAASRSSSSGHGGAGFPLPVTSVPANGRSSAPGPNSMTVTSGSHSSSGSNCSTGSLTGGMELTNTMVATTQRTGPNNVLVNGHSTGNHFHGGVTQRVAASAAPTECNVLPTYTGSSSSYQPTSFQSMAVHTPPAYTLRQIPPAHSIGYPYTSTAPTSESIILTAPTTTPSSTVYHTTQGSAIVKPLSDNQSQRDKLPYLMHKSQWHSNVTGHVPLSPGLPRRFVDGVLPPETSAHIQYSSGQSSPSPAGSATPVPTPRRESLAGSVPVRAGPAPPALATHELSSDANCTLTPPPVATRPEKTKSIYTKPVEAQCDGHLTIGDQQDASRRSLETPVPPQTAATIHGSENETRTNVTVLPTVHSDGNNSSVHAYQQATESRPLKPNTLERQGQKKVRPKISDEAIQEKLRMIVSIGDPNRKYQRQEKIGQGASGTVYGGIEVATGRRVAIKQMNLKQQPKKELIVNEIYVMKAKKHPNVVNYLDSYLVADELWVVMEYLDGGSLTEVVTETYMEEGQIAAVCRECLQALDFLHKNQVIHRDIKSDNILLGLDGSVKLTDFGFCAQLSSEQNKRSTMVGTPYWMAPEVVTRKQYGPKVDIWSLGIMAIEMLDGEPPYLNENPVRALYLIGTNGKPEIKERDKLSSEFQDFLDLCLEVKVERRATAQELLQHIFSRDGHRAMELLQTDNFHSSGVRKKRTPRLAIEKLVDPEVKRNYQNQLVECLPDGTVSDINGHWEKISKALLKPRRTVVMAAGEDELVVTVRGTSFNCPPTSLVEPNTGIIAPLIEPHHRGIGSYALEVVADIIGTLDYCGIAFLTMGSFVPYLYYSFYCVLWLKLFYLALIFALGSGAIAVSMSNTFASPAYRPLRALVFIALGLSGVIPCVHVTITNGFWPSLQHGSLGWLFLMAVLYITGASIYAVRVPERIFPGRFDIWFQSHQIFHVFVVAAALVHYHGIIGLTNYRLAIGDCRPPPGYPFPKHDYDNIELLRPFMTY,negative +UUGUUACACACCCGCUUGAAAAAGCAAGUCUGACAA,MAIPKELLVLLLGIAILSKVAECAAFGSRRGLVETVFDVTRFGARPNTPADSTRGLMMAWRSACQSPGPAKVVIPPGTYTTGETIFQGPCTSPRPITIEIQGTLLSNTDMSLYTRAAWISIEHVDGIVITGGGTLNGQGKSSWQFADKSGSTPPLPSSLVFQTVRSSSIKNLNFVDAKGVHLKITDSSDISVSNIKITAPGDSPNTDGLHISDTINVNVTDSTIGTGDDCISIGDGNSNVYISNINCGPGHGISIGSLGKRLDETDVKGVTVRNCTFRGTTNGARIKTYMGSPSLQVSGVVYEDIILDNVKNPIVIDQHYHSKNRNEPSRVKLVDIHFRNIRGTTTSKIPVLLNCSEALPCEGVELVDIDLAPVGSIGPLLPATCQNAKTILNGKNNPPAC,negative +GUUCACUCGAAUCUUCAGAACACGCAACGG,MPSKKNGRSGPQPHKRWVFTLNNPSEDERKKIRELPISLFDYFIVGEEGNEEGRTPHLQGFANFVKKQTFNKVKWYLGARCHIEKAKGTDQQNKEYCSKEGNLLMECGAPRSQGQRSDLSTAVSTLLESGSLVTVAEQHPVTFVRNFRGLAELLKVSGKMQKRDWKTNVHVIVGPPGCGKSKWAANFADPETTYWKPPRNKWWDGYHGEEVVVIDDFYGWLPWDDLLRLCDRYPLTVETKGGTVPFLARSILITSNQTPLEWYSSAAVPAVEALYRRITSLVFWKNATEQSTEEGGQFVTLSPPCPEFPYEINY,negative +AATACCCCCCCTTCGGTGCCTCTTCAGTTAAAAATAACTGAAGAGGCACCGAAGGGGGGG,MEGMLKGEGPGPLPPLLQQYVELRDQYPDYLLLFQVGDFYECFGEDAERLARALGLVLTHKTSKDFTTPMAGIPLRAFEAYAERLLKMGFRLAVADQVEPAEEAEGLVRREVTQLLTPGTLLQESLLPREANYLAAIATGDGWGLAFLDVSTGEFKGTVLKSKSALYDELFRHRPAEVLLAPELLENGAFLDEFRKRFPVMLSEAPFEPEGEGPLALRRARGALLAYAQRTQGGALSLQPFRFYDPGAFMRLPEATLRALEVFEPLRGQDTLFSVLDETRTAPGRRLLQSWLRHPLLDRGPLEARLDRVEGFVREGALREGVRRLLYRLADLERLATRLELGRASPKDLGALRRSLQILPELRALLGEEVGLPDLSPLKEELEAALVEDPPLKVSEGGLIREGYDPDLDALRAAHREGVAYFLELEERERERTGIPTLKVGYNAVFGYYLEVTRPYYERVPKEYRPVQTLKDRQRYTLPEMKEKEREVYRLEALIRRREEEVFLEVRERAKRQAEALREAARILAELDVYAALAEVAVRYGYVRPRFGDRLQIRAGRHPVVERRTEFVPNDLEMAHELVLITGPNMAGKSTFLRQTALIALLAQVGSFVPAEEAHLPLFDGIYTRIGASDDLAGGKSTFMVEMEEVALILKEATENSLVLLDEVGRGTSSLDGVAIATAVAEALHERRAYTLFATHYFELTALGLPRLKNLHVAAREEAGGLVFYHQVLPGPASKSYGVEVAAMAGLPKEVVARARALLQAMAARREGALDAVLERLLALDPDRLTPLEALRLLQELKALALGAPLDTMKG,negative +TCCCTACGGCGCTAACGGATCAAACATGCGCTCCAAGGAGTAGGGGCCACCGTGCTACAAC,MNQTAILICCLIFLTLSGIQGVPLSRTVRCTCISISNQPVNPRSLEKLEIIPASQFCPRVEIIATMKKKGEKRCLNPESKAIKNLLKAVSKERSKRSP,negative +CCACAGTACTACCGTATAACATGATGTCAA,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +AGUGAGGUCAACGAUCUUGGGCCCGUUGACGGGAAGCGUAGAACUACAAGCUUCUGGACUCGGU,MSPQRDRINAFYKDNPHPKGSRIVINREHLMIDRPYVLLAVLFVMFLSLIGLLAIAGIRLHRAAIYTAEIHKSLSTNLDVTNSIEHQVKDVLTPLFKIIGDEVGLRTPQRFTDLVKFISDKIKFLNPDREYDFRDLTWCINPPERIKLDYDQYCADVAAEELMNALVNSTLLEARATNQFLAVSKGNCSGPTTIRGQFSNMSLSLLDLYLSRGYNVSSIVTMTSQGMYGGTYLVEKPNLSSKGSELSQLSMHRVFEVGVIRNPGLGAPVFHMTNYFEQPVSNDFSNCMVALGELKFAALCHREDSITIPYQGSGKDVSFQLVKLGVWKSPTDMQSWVPLSTDDPVIDRLYLSSHRGVIADNQAKWAVPTTRTDDKLRMETCFQQACKGKIQALCENPDWAPLKDNRIPSYGVLSVNLSLTVELKIKIASGFGPLITHGSGMDLYKSNHNNMYWLTIPPMKNLALGVINTLEWIPRFRVSPNLFTVPIKEAGEDCHAPTYLPAEVDGDVKLSSNLVILPGQDLQYVLATYDTSRVEHAVVYYVYSPSRSFSYFYPFRLPIKGVPIELQVECFTWDQKLWCRHFCVLADSGSGGHITHSGMVGMGVSCTVTREDGTNRR,negative +GACAGCACGAAUAAAACCUGCGUAAAUCCGCCCCAUUUGUGUAAGGGUAGUGGG,ASFTCLAIWALASAGVVPLVLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAAFFFVPVIISTVCYVSIIRCLSSSAVANRSKK,negative +AAGACGGCCCGGUGUGUAGCCGGAGAUCCGAGACUUGCU,MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA,negative +AAGGACAGCACGAAUAAAACCUGCGUAAAUCCGCCCCAUUUGUGUAAGGGUAGUGGG,MSGGDGRGHNTGAHSTSGNINGGPTGLGVGGGASDGSGWSSENNPWGGGSGSGIHWGGGSGHGNGGGNGNSGGGSGTGGNLSAVAAPVAFGFPALSTPGAGGLAVSISAGALSAAIADIMAALKGPFKFGLWGVALYGVLPSQIAKDDPNMMSKIVTSLPADDITESPVSSLPLDKATVNVNVRVVDDVKDERQNISVVSGVPMSVPVVDAKPTERPGVFTASIPGAPVLNISVNNSTPAVQTLSPGVTNNTDKDVRPAGFTQGGNTRDAVIRFPKDSGHNAVYVSVSDVLSPDQVKQRQDEENRRQQEWDATHPVEAAERNYERARAELNQANEDVARNQERQAKAVQVYNSRKSELDAANKTLADAIAEIKQFNRFAHDPMAGGHRMWQMAGLKAQRAQTDVNNKQAAFDAAAKEKSDADAALSSAMESRKKKEDKKRSAENNLNDEKNKPRKGFKDYGHDYHPAPKTENIKGLGDLKPGIPKTPKQNGGGKRKRWTGDKGRKIYEWDSQHGELEGYRASDGQHLGSFDPKTGNQLKGPDPKRNIKKYL,negative +CAAGAACTCCTAAGTATAATGTGAGGGATCCGAAATTCTGCTCTTATGTATGGCAAGATT,MHGDTPTLHEYMLDLQPETTDLYCYEQLNDSSEEEDEIDGPAGQAEPDRAHYNIVTFCCKCDSTLRLCVQSTHVDIRTLEDLLMGTLGIVCPICSQKP,negative +GCGGACCCGCCGAAAACGCAACCGUGCACAAUUCUGAGCAUGGGCGGGCCAGUACUACAAGCUUCUGGACUCGGU,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +CATCTCGGTCGTGAACTTTACATGCATGAGTATTTTGGTG,MIPPPRRSASSTPKDYRSSRDLQPWRGVSSGDAAETSQQSRHRRDAIADGGGRLKGAAQSSPSSGTRRSGPYAQGRAMPKNENIPKPGKQRLGPRKKKLSTLKKKILLDRLERWRDKQHEGALSTPSATASSEEAKCNNPFPLCPPGELSPPPSPPATICPAVVDKSTSYGQVGGANGERSVWAITIYNLVDQEDVEDDDDHAEIERDLWDMSSAFGVVRSVQVPRGTAVQVSDAEVSAAAAAGEPAAVAAKVAFATNAEAECARDGLNGRIVGGKPLLVRIHRCDGHFCGGVCPGDPDGSGLWRVAIENLIDEEDDLDDEDEYAEISANVSAMMGCYGKLVDVQVRRSSPSKGEVQEDVATRAATTAGATQAVVVTFGSLAEAEACVQGIKGCRVGGKELDAHVVLDSERVLPSNPAFKCDQEHAHSSDVAAAVAGQGDSMMKQEAGTEPSPCVDQDTAAAVASSTEWRVVIRGLIDEDDLQDDDDDYAEVCSDVTALVSSYGAVVGLDIPRGRETGSCCYGAEPGEAVVVFRSLQEAEACARGLSGRKVAGNILDAQVLTQPAPSQQGPLQGGASGTGPPVANRERKPAKECPLPQHQASSHQSCGKVPELDGSGPGMLRGFGNRVEDCCGRPKIACTDSDEPQAIAAAAPPGQSIEGPKTTALAKAGKRIQTKYQEAAALPKPPGVRGGLPNAYVNQPPDKEVNDLVFEMLQLLFKFQERARLSDPSKAKTRRRLVIGLREVLRGVKAKKVRLLIVAPNVDAVGGEGGLDDKVVEIIDKAREAEYPVVFALSKRKIGKALGKTIKVSAVGVYSFDGANEQQKQLKRRMETISSLPSPSPRQSDPPTDDALASPPSSSACGDSQDPAGKGSRV,negative +ACCUAGCGCGCUUGACGUGGCCCCUUCGCAGGUCCUGGAU,MGCRRTREGPSKAMIFPWKCQSTQRDLWNIFKLWGWTMLCCDFLAHHGTDCWTYHYSEKPMNWQRARRFCRDNYTDLVAIQNKAEIEYLEKTLPFSRSYYWIGIRKIGGIWTWVGTNKSLTEEAENWGDGEPNNKKNKEDCVEIYIKRNKDAGKWNDDACHKLKAALCYTASCQPWSCSGHGECVEIINNYTCNCDVGYYGPQCQFVIQCEPLEAPELGTMDCTHPLGNFSFSSQCAFSCSEGTNLTGIEETTCGPFGNWSSPEPTCQVIQCEPLSAPDLGIMNCSHPLASFSFTSACTFICSEGTELIGKKKTICESSGIWSNPSPICQKLDKSFSMIKEGDYNPLFIPVAVMVTAFSGLAFIIWLARRLKKGM,negative +AATAGGGGGGGTTCGGTGCAAAGCACCGAACCCCCCC,MSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA,negative +CTTCTGCCCGCCTCCTTCCGTGGGGATGCCATTGGTCCACAGGGTTATGGGAGCATCAGGAGACGAGATAGGCGGACACT,AKVLVVLLLFAGVDAETHVTGGSAAHAASTFAGLFSPGAKQDIQLINTNGSWHINRTA,negative +TTGCGCGTTAATTGGGGGGGTGGGTGGGTT,MRKIVVAAIAVSLTTVSITASASADPSKDSKAQVSAAEAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKVKPSAASIDAAKKAGVNNGNPLDAVQQ,negative +AUAGCCUCCGAUCCGCUAACUCUAACCCGCCAACUCCU,MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA,negative +AGGGAGCAAUGAACUCAAGUCAAGCCGGGCACGUGGG,MLDLFADAEPWQEPLAAGAVILRRFAFNAAEQLIRDINDVASQSPFRQMVTPGGYTMSVAMTNCGHLGWTTHRQGYLYSPIDPQTNKPWPAMPQSFHNLCQRAATAAGYPDFQPDACLINRYAPGAKLSLHQDKDEPDLRAPIVSVSLGLPAIFQFGGLKRNDPLKRLLLEHGDVVVWGGESRLFYHGIQPLKAGFHPLTIDCRYNLTFRQAGKKE,negative +GTTTCCAAAGCCGGGGGGGTGGGATGGGTT,AKVLVVLLLFAGVDAETHVTGGSAAHAASTFAGLFSPGAKQDIQLINTNGSWHINRTA,negative +BCGAGGCGTGTGCAAGGCGTGTTGTTCAAAGGTGTGTGTGT,MVMGLGVLLLVFVLGLGLTPPTLAQDNSRYTHFLTQHYDAKPQGRDDRYCESIMRRRGLTSPCKDINTFIHGNKRSIKAICENKNGNPHRENLRISKSSFQVTTCKLHGGSPWPPCQYRATAGFRNVVVACENGLPVHLDQSIFRRP,negative +TATTAATAATAATATTAATAATAA,MEGMLKGEGPGPLPPLLQQYVELRDQYPDYLLLFQVGDFYECFGEDAERLARALGLVLTHKTSKDFTTPMAGIPLRAFEAYAERLLKMGFRLAVADQVEPAEEAEGLVRREVTQLLTPGTLLQESLLPREANYLAAIATGDGWGLAFLDVSTGEFKGTVLKSKSALYDELFRHRPAEVLLAPELLENGAFLDEFRKRFPVMLSEAPFEPEGEGPLALRRARGALLAYAQRTQGGALSLQPFRFYDPGAFMRLPEATLRALEVFEPLRGQDTLFSVLDETRTAPGRRLLQSWLRHPLLDRGPLEARLDRVEGFVREGALREGVRRLLYRLADLERLATRLELGRASPKDLGALRRSLQILPELRALLGEEVGLPDLSPLKEELEAALVEDPPLKVSEGGLIREGYDPDLDALRAAHREGVAYFLELEERERERTGIPTLKVGYNAVFGYYLEVTRPYYERVPKEYRPVQTLKDRQRYTLPEMKEKEREVYRLEALIRRREEEVFLEVRERAKRQAEALREAARILAELDVYAALAEVAVRYGYVRPRFGDRLQIRAGRHPVVERRTEFVPNDLEMAHELVLITGPNMAGKSTFLRQTALIALLAQVGSFVPAEEAHLPLFDGIYTRIGASDDLAGGKSTFMVEMEEVALILKEATENSLVLLDEVGRGTSSLDGVAIATAVAEALHERRAYTLFATHYFELTALGLPRLKNLHVAAREEAGGLVFYHQVLPGPASKSYGVEVAAMAGLPKEVVARARALLQAMAARREGALDAVLERLLALDPDRLTPLEALRLLQELKALALGAPLDTMKG,negative +CTCCTCTGACTGTAACCACGCCGAAGAGCCTTTTTAGCGTACTGAAAAGGAGTTACTCTCGCATAGGTAGTCCAGAAGCC,MTRCTADNSLTNPAYRRRTMATGEMKEFLGIKGTEPTDFGINSDAQDLPSPSRQASTRRMSIGESIDGKINDWEEPRLDIEGFVVDYFTHRIRQNGMEWFGAPGLPCGVQPEHEMMRVMGTIFEKKHAENFETFCEQLLAVPRISFSLYQDVVRTVGNAQTDQCPMSYGRLIGLISFGGFVAAKMMESVELQGQVRNLFVYTSLFIKTRIRNNWKEHNRSWDDFMTLGKQMKEDYERAEAEKVGRRKQNRRWSMIGAGVTAGAIGIVGVVVCGRMMFSLK,negative +GGUAGAUACGAUGGAUCAGGGUACCCCCUGUGGCCCGUCAACACAGGGGAAGUGGCAUGACGCGCAGCCA,MDSTNYISKLFEYAQRQGQISDIKFEEVGTDGPDHLKTFTLRVVIKGHAYPNGVGKTKKEAKRNAAKHALIGMMETTEQKDASVSCPPSPAPSPAPPVRAVISQPKYVSWLNEHSQKNKLSLKALEGARVGPNNTSQCCRYVVGEKEYPEGFGNTKKEAKEEAAMQVYLELCGGSQTTGTVDENCNGTTGKHKEELNGKVVVLSEKVEHMNMSPAQNVPEQYSFITTEETNFIGILNHYCQKTKRFLDFKLVEKSGPSHNPQFVYKVLIDKREYPDGLGKTAKEAKQQAAQLAWSALQEQSDWNSQVSCRSTVSEEGGLSSLTPSSTWESQDATPSSLSIAGSTSESIIFSDSVNVSSPKDESPVNVKPKIRLAANFQMSPVKTKQEGPNLKGNDLGTLSSGRTSNQPVISRFSSEFDSIENIGKGGFGHVYKARRKLEQKYFAVKIVRSKGKAKREVGALADLQHPNIVRYYTAWLEDTAYRCDTASESDTTSDSGSSSSSEFLYIQMELCDKRTLKVWIDERNAHRKPKRREESLSITQQIVNGVEYIHSKKLLHRDLKPANIMFGMSDGEGKGEVKIGDFGLVTAEDNDNDENLLERTKKTGTVSYMAPEQRNQTSYDRKVDIFALGLIYFEPLWDLSGMEKAKVWNDVRSQRFPQQFNSQFTLENKVIESLLCANPEERPDARQLKTKLNECSRVLTRVHNIHQDNRTI,negative +GTCCAGCTAAATCTCTACGAACCCCGCATTCCCCGTAACT,MGLLGILCFLIFLGKTWGQEQTYVISAPKIFRVGASENIVIQVYGYTEAFDATISIKSYPDKKFSYSSGHVHLSSENKFQNSAILTIQPKQLPGGQNPVSYVYLEVVSKHFSKSKRMPITYDNGFLFIHTDKPVYTPDQSVKVRVYSLNDDLKPAKRETVLTFIDPEGSEVDMVEEIDHIGIISFPDFKIPSNPRYGMWTIKAKYKEDFSTTGTAYFEVKEYVLPHFSVSIEPEYNFIGYKNFKNFEITIKARYFYNKVVTEADVYITFGIREDLKDDQKEMMQTAMQNTMLINGIAQVTFDSETAVKELSYYSLEDLNNKYLYIAVTVIESTGGFSEEAEIPGIKYVLSPYKLNLVATPLFLKPGIPYPIKVQVKDSLDQLVGGVPVTLNAQTIDVNQETSDLDPSKSVTRVDDGVASFVLNLPSGVTVLEFNVKTDAPDLPEENQAREGYRAIAYSSLSQSYLYIDWTDNHKALLVGEHLNIIVTPKSPYIDKITHYNYLILSKGKIIHFGTREKFSDASYQSINIPVTQNMVPSSRLLVYYIVTGEQTAELVSDSVWLNIEEKCGNQLQVHLSPDADAYSPGQTVSLNMATGMDSWVALAAVDSAVYGVQRGAKKPLERVFQFLEKSDLGCGAGGGLNNANVFHLAGLTFLTNANADDSQENDEPCKEILRPRRTLQKKIEEIAAKYKHSVVKKCCYDGACVNNDETCEQRAARISLGPRCIKAFTECCVVASQLRANISHKDMQLGRLHMKTLLPVSKPEIRSYFPESWLWEVHLVPRRKQLQFALPDSLTTWEIQGVGISNTGICVADTVKAKVFKDVFLEMNIPYSVVRGEQIQLKGTVYNYRTSGMQFCVKMSAVEGICTSESPVIDHQGTKSSKCVRQKVEGSSSHLVTFTVLPLEIGLHNINFSLETWFGKEILVKTLRVVPEGVKRESYSGVTLDPRGIYGTISRRKEFPYRIPLDLVPKTEIKRILSVKGLLVGEILSAVLSQEGINILTHLPKGSAEAELMSVVPVFYVFHYLETGNHWNIFHSDPLIEKQKLKKKLKEGMLSIMSYRNADYSYSVWKGGSASTWLTAFALRVLGQVNKYVEQNQNSICNSLLWLVENYQLDNGSFKENSQYQPIKLQGTLPVEARENSLYLTAFTVIGIRKAFDICPLVKIDTALIKADNFLLENTLPAQSTFTLAISAYALSLGDKTHPQFRSIVSALKREALVKGNPPIYRFWKDNLQHKDSSVPNTGTARMVETTAYALLTSLNLKDINYVNPVIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVKQLRLSMDIDVSYKHKGALHNYKMTDKNFLGRPVEVLLNDDLIVSTGFGSGLATVHVTTVVHKTSTSEEVCSFYLKIDTQDIEASHYRGYGNSDYKRIVACASYKPSREESSSGSSHAVMDISLPTGISANEEDLKALVEGVDQLFTDYQIKDGHVILQLNSIPSSDFLCVRFRIFELFEVGFLSPATFTVYEYHRPDKQCTMFYSTSNIKIQKVCEGAACKCVEADCGQMQEELDLTISAETRKQTACKPEIAYAYKVSITSITVENVFVKYKATLLDIYKTGEAVAEKDSEITFIKKVTCTNAELVKGRQYLIMGKEALQIKYNFSFRYIYPLDSLTWIEYWPRDTTCSSCQAFLANLDEFAEDIFLNGC,negative +BAGCGCCGGTGGTGGTGGGGGTTGTTGTTACGCGGTATTAT,MAIPKELLVLLLGIAILSKVAECAAFGSRRGLVETVFDVTRFGARPNTPADSTRGLMMAWRSACQSPGPAKVVIPPGTYTTGETIFQGPCTSPRPITIEIQGTLLSNTDMSLYTRAAWISIEHVDGIVITGGGTLNGQGKSSWQFADKSGSTPPLPSSLVFQTVRSSSIKNLNFVDAKGVHLKITDSSDISVSNIKITAPGDSPNTDGLHISDTINVNVTDSTIGTGDDCISIGDGNSNVYISNINCGPGHGISIGSLGKRLDETDVKGVTVRNCTFRGTTNGARIKTYMGSPSLQVSGVVYEDIILDNVKNPIVIDQHYHSKNRNEPSRVKLVDIHFRNIRGTTTSKIPVLLNCSEALPCEGVELVDIDLAPVGSIGPLLPATCQNAKTILNGKNNPPAC,negative +GGGAGGACGATGCGGAGTTTCTTCTGAGGTCTGAACCTTTCGAAAGCTGGCGCTCAGACGACTCGCCCGA,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,negative +CTTCTGCCCGCCTCCTTCCAGCCGTCACAGGTCGCTCATTCATTACGGTCTGTTTGCGGGAGACGAGATAGGCGGACACT,AKTALQVPLPHPMQMNALGGYSPASTCNGYGRMGLHQEKLPSDLDGMFIERLDCDMESIIRNDLMDGDTLDFNFDNVLPNQSFPHSVKTTTHSWVSG,negative +ATGGCTGTGGTGGAGGGCCGAAGCCTGTACAAAACAGGAATGCGCTTATCTTGGAGTAT,MEGMLKGEGPGPLPPLLQQYVELRDQYPDYLLLFQVGDFYECFGEDAERLARALGLVLTHKTSKDFTTPMAGIPLRAFEAYAERLLKMGFRLAVADQVEPAEEAEGLVRREVTQLLTPGTLLQESLLPREANYLAAIATGDGWGLAFLDVSTGEFKGTVLKSKSALYDELFRHRPAEVLLAPELLENGAFLDEFRKRFPVMLSEAPFEPEGEGPLALRRARGALLAYAQRTQGGALSLQPFRFYDPGAFMRLPEATLRALEVFEPLRGQDTLFSVLDETRTAPGRRLLQSWLRHPLLDRGPLEARLDRVEGFVREGALREGVRRLLYRLADLERLATRLELGRASPKDLGALRRSLQILPELRALLGEEVGLPDLSPLKEELEAALVEDPPLKVSEGGLIREGYDPDLDALRAAHREGVAYFLELEERERERTGIPTLKVGYNAVFGYYLEVTRPYYERVPKEYRPVQTLKDRQRYTLPEMKEKEREVYRLEALIRRREEEVFLEVRERAKRQAEALREAARILAELDVYAALAEVAVRYGYVRPRFGDRLQIRAGRHPVVERRTEFVPNDLEMAHELVLITGPNMAGKSTFLRQTALIALLAQVGSFVPAEEAHLPLFDGIYTRIGASDDLAGGKSTFMVEMEEVALILKEATENSLVLLDEVGRGTSSLDGVAIATAVAEALHERRAYTLFATHYFELTALGLPRLKNLHVAAREEAGGLVFYHQVLPGPASKSYGVEVAAMAGLPKEVVARARALLQAMAARREGALDAVLERLLALDPDRLTPLEALRLLQELKALALGAPLDTMKG,negative +ATATTCGCGATTATT,MIPPPRRSASSTPKDYRSSRDLQPWRGVSSGDAAETSQQSRHRRDAIADGGGRLKGAAQSSPSSGTRRSGPYAQGRAMPKNENIPKPGKQRLGPRKKKLSTLKKKILLDRLERWRDKQHEGALSTPSATASSEEAKCNNPFPLCPPGELSPPPSPPATICPAVVDKSTSYGQVGGANGERSVWAITIYNLVDQEDVEDDDDHAEIERDLWDMSSAFGVVRSVQVPRGTAVQVSDAEVSAAAAAGEPAAVAAKVAFATNAEAECARDGLNGRIVGGKPLLVRIHRCDGHFCGGVCPGDPDGSGLWRVAIENLIDEEDDLDDEDEYAEISANVSAMMGCYGKLVDVQVRRSSPSKGEVQEDVATRAATTAGATQAVVVTFGSLAEAEACVQGIKGCRVGGKELDAHVVLDSERVLPSNPAFKCDQEHAHSSDVAAAVAGQGDSMMKQEAGTEPSPCVDQDTAAAVASSTEWRVVIRGLIDEDDLQDDDDDYAEVCSDVTALVSSYGAVVGLDIPRGRETGSCCYGAEPGEAVVVFRSLQEAEACARGLSGRKVAGNILDAQVLTQPAPSQQGPLQGGASGTGPPVANRERKPAKECPLPQHQASSHQSCGKVPELDGSGPGMLRGFGNRVEDCCGRPKIACTDSDEPQAIAAAAPPGQSIEGPKTTALAKAGKRIQTKYQEAAALPKPPGVRGGLPNAYVNQPPDKEVNDLVFEMLQLLFKFQERARLSDPSKAKTRRRLVIGLREVLRGVKAKKVRLLIVAPNVDAVGGEGGLDDKVVEIIDKAREAEYPVVFALSKRKIGKALGKTIKVSAVGVYSFDGANEQQKQLKRRMETISSLPSPSPRQSDPPTDDALASPPSSSACGDSQDPAGKGSRV,negative +CATGCGCCTTCCCCCTGTGGTTGGTGTCAGCCGGCCTGTG,MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQRGLKNVFDEAILAALEPPETQPKRKCCIF,negative +AGAGUCGCUGAUGGUAGACGCCGGCGGAUC,AKVLVVLLLFAGVDAETHVTGGSAAHAASTFAGLFSPGAKQDIQLINTNGSWHINRTA,negative +ACCGAAAAAGACCUGACUUCUAUACUAAGUCUACGUUCC,SNTRNFVLRDEDGNEHGVFTGKQPRQAALKAANRGSGTKANPDIIRLRERGTKKVHVFKAWKEIVDAPKNRPAWMPEKISKPFVKKERIEKLE,negative +GCCCUCCAACCACACCCCGCCAACAACCCC,MLSWGYFLFLLPTLPGAQSQVQLVESGGDVRKPGDSLRLSCKGSGFTFSNYWLGWVRQAPGKALNGSLPLTPLAAAPTYIPGVSGRFTISRDNARALLHLDMSDLRPEDTGRYHCER,negative +UAUCCUCGCCCGUGCACGCCCUCCACUAAGCCCA,MKEFEVKVASTAFVLVLFSLTINQILASETSTKFRSPVPAPTVPDWNHLPNEGNEENVVSAPKQDGASGGQKPYWTKREKMMKRLHAEPAGNTVRFRCAVDGNPKPQVLWYKNDLIVQKNDRVGGYKYRNQVLILESVVLSDKGNYMCVARNEYGSINHTYQLDVQERSASKPILAEGLPQNKSAYIGDDVTFKCKVYSDAHPHIQWLKSINNHNNAAPNYTVLKAAGVNTTDLDMEVLILKNVSFEEAGEYTCLAGNSIGISHQSAWLSVLPVPPPTTDTITKGIPNETNIIIYVMCGVLVILFGLAVVLVLYYHCYNGKDPPMLVRIENPDNIPPMTKIEHPTMLFGNTQAWQRMCMPMQEPFEFNIQLDLQWELQREDITLVERLDEGFFGQVFKADLVTCNNTRKEKMVCAVKMLKGNRNEKDVLDLLTEMDQMKRVGKHKNIINLLGVCTQNGPLWLVIEYAAQGNLRDYLRRNRPQNTLCNLVLPSEGRNPDDELPVPHGDTLTQKDIVSFAFQVARGLEFLAQKKCIHRDLAARNVLVTEELVMKIADFGLARDIRSCDYYRKHTRGHLPYKWMALEAMSDNIFTHATDVWSFGVLLWEIFSLAGSPYPGIKTHELVKFLRSGERLDKPQYASQEMYRLMRDCWEEDPSKRPNFRTLVEDLDRMLAESSTEVYIDFAAGCEAEYSESSEDESESQNSDEEDDDSVFERMRQIDSLSNGNIPFNEEDSSNSDPYVAPLLQNEENVLQNEHARLRSEA,negative +CGAATACCTGGAGGAACACGGGAAAAGATCACTGAAGCCA,MPFVNKQFNYKDPVNGVDIAYIKIPNVGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAGHRLYGIAINPNRVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNRKTYLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLKNFTGLFEFYKLLCVRGIITSKTKSLDKGYNKALNDLCIKVNNWDLFFSPSEDNFTNDLNKGEEITSDTNIEAAEENISLDLIQQYYLTFNFDNEPENISIENLSSDIIGQLELMPNIERFPNGKKYELDKYTMFHYLRAQEFEHGKSRIALTNSVNEALLNPSRVYTFFSSDYVKKVNKATEAAMFLGWVEQLVYDFTDETSEVSTTDKIADITIIIPYIGPALNIGNMLYKDDFVGALIFSGAVILLEFIPEIAIPVLGTFALVSYIANKVLTVQTIDNALSKRNEKWDEVYKYIVTNWLAKVNTQIDLIRKKMKEALENQAEATKAIINYQYNQYTEEEKNNINFNIDDLSSKLNESINKAMININKFLNQCSVSYLMNSMIPYGVKRLEDFDASLKDALLKYIYDNRGTLIGQVDRLKDKVNNTLSTDIPFQLSKYVDNQRLLSTFTEYIKNIINTSILNLRYESNHLIDLSRYASKINIGSKVNFDPIDKNQIQLFNLESSKIEVILKNAIVYNSMYENFSTSFWIRIPKYFNSISLNNEYTIINCMENNSGWKVSLNYGEIIWTLQDTQEIKQRVVFKYSQMINISDYINRWIFVTITNNRLNNSKIYINGRLIDQKPISNLGNIHASNNIMFKLDGCRDTHRYIWIKYFNLFDKELNEKEIKDLYDNQSNSGILKDFWGDYLQYDKPYYMLNLYDPNKYVDVNNVGIRGYMYLKGPRGSVMTTNIYLNSSLYRGTKFIIKKYASGNKDNIVRNNDRVYINVVVKNKEYRLATNASQAGVEKILSALEIPDVGNLSQVVVMKSKNDQGITNKCKMNLQDNNGNDIGFIGFHQFNNIAKLVASNWYNRQIERSSRTLGCSWEFIPVDDGWGERPL,negative +AGGAUGGAUCGAGCGCUGGAGUCUGGAGAAUGUCAC,MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYTFLLPEMDNCRSSSSPYVSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQDNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVLVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF,negative +GAAGCUUUCACACAACAAGGCCCGGGACUGUAUUAGGGAAAUUAGAGUACAGACAGUCGCCGUGGGUCGAAUUCCGCUCA,MASNFTQFVLVDNGGTGDVTVAPSNFANGVAEWISSNSRSQAYKVTCSVRQSSAQNRKYTIKVEVPKVATQTVGGVELPVAAWRSYLNMELTIPIFATNSDCELIVKAMQGLLKDGNPIPSAIAANSGIY,negative +UCGGAGGUGGUUCAGCUCUGCAUCGACAGUUGGC,MRKIVVAAIAVSLTTVSITASASADPSKDSKAQVSAAEAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKVKPSAASIDAAKKAGVNNGNPLDAVQQ,negative +GAAUCAAUACACAGUCCUGGGUGCUAACCAUGAACACCCAAGGCCUUAGUGGUAUGUGGUUCUUG,MVMGLGVLLLVFVLGLGLTPPTLAQDNSRYTHFLTQHYDAKPQGRDDRYCESIMRRRGLTSPCKDINTFIHGNKRSIKAICENKNGNPHRENLRISKSSFQVTTCKLHGGSPWPPCQYRATAGFRNVVVACENGLPVHLDQSIFRRP,negative +AGCAACCU,MGVHECPAWLWLLLSLLSLPLGLPVLGAPPRLICDSRVLERYLLEAKEAENITTGCAEHCSLNENITVPDTKVNFYAWKRMEVGQQAVEVWQGLALLSEAVLRGQALLVNSSQPWEPLQLHVDKAVSGLRSLTTLLRALGAQKEAISPPDAASAAPLRTITADTFRKLFRVYSNFLRGKLKLYTGEACRTGDR,negative +CGCACTGAAGTGGGATACCGCCTAAACGG,MKPGGNTIVIWMYAVATWLCFGSTSGWSFTLEDNNIFPKQYPIINFTTAGATVQSYTNFIRAVRGRLTTGADVRHEIPVLPNRVGLPINQRFILVELSNHAELSVTLALDVTNAYVVGYRAGNSAYFFHPDNQEDAEAITHLFTDVQNRYTFAFGGNYDRLEQLAGNLRENIELGNGPLEEAISALYYYSTGGTQLPTLARSFIICIQMISEAARFQYIEGEMRTRIRYNRRSAPDPSVITLENSWGRLSTAIQESNQGAFASPIQLQRRNGSKFSVYDVSILIPIIALMVYRCAPPPSSQFSLLIRPVVPNFNADVCMDPEPIVRIVGRNGLCVDVRDGRFHNGNAIQLWPCKSNTDANQLWTLKRDNTIRSNGKCLTTYGYSPGVYVMIYDCNTAATDATRWQIWDNGTIINPRSSLVLAATSGNSGTTLTVQTNIYAVSQGWLPTNNTQPFVTTIVGLYGLCLQANSGQVWIEDCSSEKAEQQWALYADGSIRPQQNRDNCLTSDSNIRETVVKILSCGPASSGQRWMFKNDGTILNLYSGLVLDVRASDPSLKQIILYPLHGDPNQIWLPLF,negative +GGGUUCGCUAAGUUGGUCUACCCCUCUCGAAUAUCCGUUA,MSSSQKKAGGKAGKPTKRSQNYAALRKAQLPKPPALKVPVVKPTNTILPQTGCVWQSLGTPLSLSSFNGLGARFLYSFLKDFVGPRILEEDLIYRMVFSITPSHAGTFCLTDDVTTEDGRAVAHGNPMQEFPHGAFHANEKFGFELVFTAPTHAGMQNQNFKHSYAVALCLDFDAQPEGSKNPSFRFNEVWVERKAFPRAGPLRSLITVGLFDEADDLDRH,negative +AGCCAGTCAAGTTAATGGGTGCCATGCAGAAGCA,MHGDTPTLHEYMLDLQPETTDLYCYEQLNDSSEEEDEIDGPAGQAEPDRAHYNIVTFCCKCDSTLRLCVQSTHVDIRTLEDLLMGTLGIVCPICSQKP,negative +UAAUACGACUCACUAUAGGGAGGACGAUGCGGAAUUGAGGGACCACGCGCUGCUUGUUGUGAUAAGCAGUUUGUCGUGAUGGUCGGGCGAGUCGUCUG,MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA,negative +CGAATACCTGGAGGAACACGGGAAAAGATCACTGAAGCCA,MLDLFADAEPWQEPLAAGAVILRRFAFNAAEQLIRDINDVASQSPFRQMVTPGGYTMSVAMTNCGHLGWTTHRQGYLYSPIDPQTNKPWPAMPQSFHNLCQRAATAAGYPDFQPDACLINRYAPGAKLSLHQDKDEPDLRAPIVSVSLGLPAIFQFGGLKRNDPLKRLLLEHGDVVVWGGESRLFYHGIQPLKAGFHPLTIDCRYNLTFRQAGKKE,negative +GGAGUCUUAGGCAGCGCGUUUUCGAGCUACUCCA,MSMSPKHTTPFSVSDILSPLEESYKKVGMEGGGLGAPLAAYRQGQAAPPAAAMQQHAVGHHGAVTAAYHMTAAGVPQLSHSAVGGYCNGNLGNMSELPPYQDTMRNSASGPGWYGANPDPRFPAISRFMGPASGMNMSGMGGLGSLGDVSKNMAPLPSAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGGGGGGGAGCPQQQQAQQQSPRRVAVPVLVKDGKPCQAGAPAPGAGSLQGHAQQQAQQQAQAAQAAAAAISVGSGGPGLGAHPGHQPGSAGQSPDLAHHAASPAALQGQVSSLSHLNSSGSDYGTMSCSTLLYGRTW,negative +GGGAGAGCGGAAGCGUGCUGGGCCUGUCGUUCGCUGUCUUGCUACGUUACGUUACACGGUUGGCAUAACCCAGAGGUCGAUGGAUCCCCCC,MKKRKVLIPLMALSTILVSSTGNLEVIQAEVKQENRLLNESESSSQGLLGYYFSDLNFQAPMVVTSSTTGDLSIPSSELENIPSENQYFQSAIWSGFIKVKKSDEYTFATSADNHVTMWVDDQEVINKASNSNKIRLEKGRLYQIKIQYQRENPTEKGLDFKLYWTDSQNKKEVISSDNLQLPELKQKSSNSRKKRSTSAGPTVPDRDNDGIPDSLEVEGYTVDVKNKRTFLSPWISNIHEKKGLTKYKSSPEKWSTASDPYSDFEKVTGRIDKNVSPEARHPLVAAYPIVHVDMENIILSKNEDQSTQNTDSQTRTISKNTSTSRTHTSEVHGNAEVHASFFDIGGSVSAGFSNSNSSTVAIDHSLSLAGERTWAETMGLNTADTARLNANIRYVNTGTAPIYNVLPTTSLVLGKNQTLATIKAKENQLSQILAPNNYYPSKNLAPIALNAQDDFSSTPITMNYNQFLELEKTKQLRLDTDQVYGNIATYNFENGRVRVDTGSNWSEVLPQIQETTARIIFNGKDLNLVERRIAAVNPSDPLETTKPDMTLKEALKIAFGFNEPNGNLQYQGKDITEFDFNFDQQTSQNIKNQLAELNATNIYTVLDKIKLNAKMNILIRDKRFHYDRNNIAVGADESVVKEAHREVINSSTEGLLLNIDKDIRKILSGYIVEIEDTEGLKEVINDRYDMLNISSLRQDGKTFIDFKKYNDKLPLYISNPNYKVNVYAVTKENTIINPSENGDTSTNGIKKILIFSKKGYEIG,negative +GAGGCUGAUGGCAGACGCCGGCCGAAGACA,XQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGSTGSPGPGYGYSNYGFPPYGGITFHPGVTKSNAGVTHGTINTKFKNGPKDCAKSDDEESLTLPEKETEGEGPSLPMACTKTEPIALASTMEDKEQDMGFQDNLFLEKALQLARRHANALFDYAVTGDVKMLLAVQRHLTAVQDENGDSVLHLAIIHLHAQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRVGADLSLLDRWGNSVLHLAAKEGHDRILSILLKSRKAAPLIDHPNGEGLNAIHIAVMSNSLPCLLLLVAAGAEVNAQEQKSGRTALHLAVEYDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWEKAGEDEGVVPGTTPLDMAANWQVFDILNGKPYEPVFTSDDILPQGDMKQLTEDTRLQLCKLLEIPDPDKNWATLAQKLGLGILNNAFRLSPAPSKTLMDNYEMNSGIVTASVTVVWRHPSANSALQSLLLETAHCYL,negative +TCCCACGCATTCTCCACATCTAGTCTGGTTACGGTCTCGATTGTCCCAAAAGGGCAGACACCTTTCTGTCCTTCCGTCAC,MNIKAILSLCLFLILQCVRARVFVSRLEAASLLARSRRANSPFSMEETKQGSLERECREETCNFEEAREIFEDDQRTNAFWTLYIRPNPCLSNPCQNGGTCQHTHTVYMCVCPRGWEGRVCSQEVSTGQSCKVNNGRCDHYCEEEEAAAGGRRGAVCSCAPGYHLARNRRSCMAMEAFPCGRVASPKSDILMGNSSEAATDVPTPTSQAANVNSSSIIGDDSEPQASFGHSNHRGRVVGGKECPRGQCPWQVLISRKGAPVCGGTILSPQWILTAAHCTIYETKNLRILAGEHNVDEVEGSEQELGILRIVDHPSFNIKLSYDNDISLIQLSRPIQFTRYALPICLPNQRFVRGVLRSVVAGTVSGWGKLNEFGPAAGILQRLEVPYVDDEQCRAAMGSKVITANMFCAGYETGGQDSCSGDSGGPHATRYGSTWFLTGVVSWGKGCAREGKFGVYTKVLNYLDWIAQTMAETESHALPEPAQH,negative +GCTGCAGTTGCACTGAATTCGCCTCTCGCCTCCGTACACTTAGTCGACAGGATCCGCTGAACTGACCTG,MEGMLKGEGPGPLPPLLQQYVELRDQYPDYLLLFQVGDFYECFGEDAERLARALGLVLTHKTSKDFTTPMAGIPLRAFEAYAERLLKMGFRLAVADQVEPAEEAEGLVRREVTQLLTPGTLLQESLLPREANYLAAIATGDGWGLAFLDVSTGEFKGTVLKSKSALYDELFRHRPAEVLLAPELLENGAFLDEFRKRFPVMLSEAPFEPEGEGPLALRRARGALLAYAQRTQGGALSLQPFRFYDPGAFMRLPEATLRALEVFEPLRGQDTLFSVLDETRTAPGRRLLQSWLRHPLLDRGPLEARLDRVEGFVREGALREGVRRLLYRLADLERLATRLELGRASPKDLGALRRSLQILPELRALLGEEVGLPDLSPLKEELEAALVEDPPLKVSEGGLIREGYDPDLDALRAAHREGVAYFLELEERERERTGIPTLKVGYNAVFGYYLEVTRPYYERVPKEYRPVQTLKDRQRYTLPEMKEKEREVYRLEALIRRREEEVFLEVRERAKRQAEALREAARILAELDVYAALAEVAVRYGYVRPRFGDRLQIRAGRHPVVERRTEFVPNDLEMAHELVLITGPNMAGKSTFLRQTALIALLAQVGSFVPAEEAHLPLFDGIYTRIGASDDLAGGKSTFMVEMEEVALILKEATENSLVLLDEVGRGTSSLDGVAIATAVAEALHERRAYTLFATHYFELTALGLPRLKNLHVAAREEAGGLVFYHQVLPGPASKSYGVEVAAMAGLPKEVVARARALLQAMAARREGALDAVLERLLALDPDRLTPLEALRLLQELKALALGAPLDTMKG,negative +CGTACGAAATTCGTACCTGTGTG,PGGVQVSLLKEYYEDGYHIVRDIDSTVGVSISDASLPPRTWNGFLAPKTYKNVYIDTYHNQVFDDIFRTFTIDQHVKLACSLPHGRLRGADKPLIVKEWSGAMTDCAMYLNGRGIGSRFDGSFPSGKPSGACGARSKGSSSELSAQQKKDTLRYIEAQLDAFEVGAGWYFWTW,negative +TATTAGTAATACTATTAGTAATAC,MAWYWWRRRRRRGWWKPRRRRWRRRRARRRGPARRHRARRRIVRHPCNGQTSSGNRVPRSVQAVDPKYVSLQLVWHSWDFRRGLFGQAGIKRMQQESDALTLSPVHRPKRPKRDTQVKEKTPEKDSDSAVQLRRLQPWIHSSQETKDEEEEIPEGPVQEQLLQQLQQQRLLRVQLESIAQEVLKIRRGHSLHPLLSSHA,negative +GGGAGCTCAGAATAAACGCTCAACATGGATGGGAGGGTGGGGCTGGGTTGTAGAATATTCGACATGAGGCCCGGATC,MPSNQEARLFLAVLVLAQVLPILVDSAAEKGFKQAFWQPLCQVSEELDDQPKGALFTLQAAASKIQKMRDAALRASIYAEINHGTNRAKAAVIVANHYAMKADSGLEALKQTLSSQEVTATATASYLKGRIDEYLNLLLQTKESGTSGCMMDTSGTNTVTKAGGTIGGVPCKLQLSPIQPKRPAATYLGKAGYVGLTRQADAANNFHDNDAECRLASGHNTNGLGKSGQLSAAVTMAAGYVTVANSQTAVTVQALDALQEASGAAHQPWIDAWKAKKALTGAETAEFRNETAGIAGKTGVTKLVEEALLKKKDSEASEIQTELKKYFSGHENEQWTAIEKLISEQPVAQNLVGDNQPTKLGELEGNAKLTTILAYYRMETAGKFEVLTQKHKPAESQQQAAETEGSCNKKDQNECKSPCKWHNDAENKKCTLDKEEAKKVADETAKDGKTGNTNTTGSSNSFVISKTPLWLAVLLF,negative +UAAAUCGUUGCUACAUUCCCAAUUGAACGGCCCGGGUUCUUAACACGUGC,MAIPKELLVLLLGIAILSKVAECAAFGSRRGLVETVFDVTRFGARPNTPADSTRGLMMAWRSACQSPGPAKVVIPPGTYTTGETIFQGPCTSPRPITIEIQGTLLSNTDMSLYTRAAWISIEHVDGIVITGGGTLNGQGKSSWQFADKSGSTPPLPSSLVFQTVRSSSIKNLNFVDAKGVHLKITDSSDISVSNIKITAPGDSPNTDGLHISDTINVNVTDSTIGTGDDCISIGDGNSNVYISNINCGPGHGISIGSLGKRLDETDVKGVTVRNCTFRGTTNGARIKTYMGSPSLQVSGVVYEDIILDNVKNPIVIDQHYHSKNRNEPSRVKLVDIHFRNIRGTTTSKIPVLLNCSEALPCEGVELVDIDLAPVGSIGPLLPATCQNAKTILNGKNNPPAC,negative +UCAAUCGGCGCUUUACUCUUGCGCUCACCGUGCCC,MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPGPHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR,negative +UCACUCUAUACCUCAAACGAAGUUGCACAACCCC,IMEIRTVAVGIVAIKGVESEYYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHSGGEMFVALNQKGLPVKGKKTKKEQKTAHFLPMAIT,negative +UUAGCACAAACAACCCCAGAAGUGCAACGC,IMEIRTVAVGIVAIKGVESEYYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHSGGEMFVALNQKGLPVKGKKTKKEQKTAHFLPMAIT,negative +CCUGUGUCUUGUGUGUGUGUUUUGUUUCUGGUCUA,MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPGPHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR,negative +CUCUUUUUGUCCCCGCACGUUGAACUCCUGUCCCUCUACU,MSGGDGRGHNTGAHSTSGNINGGPTGLGVGGGASDGSGWSSENNPWGGGSGSGIHWGGGSGHGNGGGNGNSGGGSGTGGNLSAVAAPVAFGFPALSTPGAGGLAVSISAGALSAAIADIMAALKGPFKFGLWGVALYGVLPSQIAKDDPNMMSKIVTSLPADDITESPVSSLPLDKATVNVNVRVVDDVKDERQNISVVSGVPMSVPVVDAKPTERPGVFTASIPGAPVLNISVNNSTPAVQTLSPGVTNNTDKDVRPAGFTQGGNTRDAVIRFPKDSGHNAVYVSVSDVLSPDQVKQRQDEENRRQQEWDATHPVEAAERNYERARAELNQANEDVARNQERQAKAVQVYNSRKSELDAANKTLADAIAEIKQFNRFAHDPMAGGHRMWQMAGLKAQRAQTDVNNKQAAFDAAAKEKSDADAALSSAMESRKKKEDKKRSAENNLNDEKNKPRKGFKDYGHDYHPAPKTENIKGLGDLKPGIPKTPKQNGGGKRKRWTGDKGRKIYEWDSQHGELEGYRASDGQHLGSFDPKTGNQLKGPDPKRNIKKYL,negative +GGACCUUUGUACCCCAGAUGAUGCUUUAUCAGGCGGAUGGGUACAAAUGGCAG,MDHLNEATQGKEHSEMSNNVSDPKGPPAKIARLEQNGSPLGRGRLGSTGAKMQGVPLKHSGHLMKTNLRKGTMLPVFCVVEHYENAIEYDCKEEHAEFVLVRKDMLFNQLIEMALLSLGYSHSSAAQAKGLIQVGKWNPVPLSYVTDAPDATVADMLQDVYHVVTLKIQLHSCPKLEDLPPEQWSHTTVRNALKDLLKDMNQSSLAKECPLSQSMISSIVNSTYYANVSAAKCQEFGRWYKHFKKTKDMMVEMDSLSELSQQGANHVNFGQQPVPGNTAEQPPSPAQLSHGSQPSVRTPLPNLHPGLVSTPISPQLVNQQLVMAQLLNQQYAVNRLLAQQSLNQQYLNHPPPVSRSMNKPLEQQVSTNTEVSSEIYQWVRDELKRAGISQAVFARVAFNRTQGLLSEILRKEEDPKTASQSLLVNLRAMQNFLQLPEAERDRIYQDERERSLNAASAMGPAPLISTPPSRPPQVKTATIATERNGKPENNTMNINASIYDEIQQEMKRAKVSQALFAKVAATKSQGWLCELLRWKEDPSPENRTLWENLSMIRRFLSLPQPERDAIYEQESNAVHHHGDRPPHIIHVPAEQIQQQQQQQQQQQQQQQAPPPPQPQQQPQTGPRLPPRQPTVASPAESDEENRQKTRPRTKISVEALGILQSFIQDVGLYPDEEAIQTLSAQLDLPKYTIIKFFQNQRYYLKHHGKLKDNSGLEVDVAEYKEEELLKDLEESVQDKNTNTLFSVKLEEELSVEGNTDINTDLKD,negative +GACUAAACGCAUUGUGCCCC,MAGRSGDSDEELLKAVRLIKFLYQSNPPPNPEGTRQARRNRRRRWRERQRQIHSISERILSTYLGRSAEPVPLQLPPLERLTLDCNEDCGTSGTQGVGSPQILVESPTILESGAKE,negative +CCGTAGGTTCGGGGTCGGAGTGGTCCGGAAGGTGGCGTGG,MVMGLGVLLLVFVLGLGLTPPTLAQDNSRYTHFLTQHYDAKPQGRDDRYCESIMRRRGLTSPCKDINTFIHGNKRSIKAICENKNGNPHRENLRISKSSFQVTTCKLHGGSPWPPCQYRATAGFRNVVVACENGLPVHLDQSIFRRP,negative +CAACUACAUGUCGACCCUGAGAAGGCUGUGGAUGUGAUUAGGCCAGUUGC,WPLTEEKIKALVEICXEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEEFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDXIIYQYMDDLYVGSDLEIGQHRTKVEELRQHLLXWGFTTPDKKHQKEPPFLWMGYELHP,negative +CCCCACCGACCGAUGAUCUUGAGCGUACAUCGCGGG,MEGMLKGEGPGPLPPLLQQYVELRDQYPDYLLLFQVGDFYECFGEDAERLARALGLVLTHKTSKDFTTPMAGIPLRAFEAYAERLLKMGFRLAVADQVEPAEEAEGLVRREVTQLLTPGTLLQESLLPREANYLAAIATGDGWGLAFLDVSTGEFKGTVLKSKSALYDELFRHRPAEVLLAPELLENGAFLDEFRKRFPVMLSEAPFEPEGEGPLALRRARGALLAYAQRTQGGALSLQPFRFYDPGAFMRLPEATLRALEVFEPLRGQDTLFSVLDETRTAPGRRLLQSWLRHPLLDRGPLEARLDRVEGFVREGALREGVRRLLYRLADLERLATRLELGRASPKDLGALRRSLQILPELRALLGEEVGLPDLSPLKEELEAALVEDPPLKVSEGGLIREGYDPDLDALRAAHREGVAYFLELEERERERTGIPTLKVGYNAVFGYYLEVTRPYYERVPKEYRPVQTLKDRQRYTLPEMKEKEREVYRLEALIRRREEEVFLEVRERAKRQAEALREAARILAELDVYAALAEVAVRYGYVRPRFGDRLQIRAGRHPVVERRTEFVPNDLEMAHELVLITGPNMAGKSTFLRQTALIALLAQVGSFVPAEEAHLPLFDGIYTRIGASDDLAGGKSTFMVEMEEVALILKEATENSLVLLDEVGRGTSSLDGVAIATAVAEALHERRAYTLFATHYFELTALGLPRLKNLHVAAREEAGGLVFYHQVLPGPASKSYGVEVAAMAGLPKEVVARARALLQAMAARREGALDAVLERLLALDPDRLTPLEALRLLQELKALALGAPLDTMKG,negative +AAGCTCTTAGTTGATGCGCGGTCAAAATTTAAGCT,MKPGGNTIVIWMYAVATWLCFGSTSGWSFTLEDNNIFPKQYPIINFTTAGATVQSYTNFIRAVRGRLTTGADVRHEIPVLPNRVGLPINQRFILVELSNHAELSVTLALDVTNAYVVGYRAGNSAYFFHPDNQEDAEAITHLFTDVQNRYTFAFGGNYDRLEQLAGNLRENIELGNGPLEEAISALYYYSTGGTQLPTLARSFIICIQMISEAARFQYIEGEMRTRIRYNRRSAPDPSVITLENSWGRLSTAIQESNQGAFASPIQLQRRNGSKFSVYDVSILIPIIALMVYRCAPPPSSQFSLLIRPVVPNFNADVCMDPEPIVRIVGRNGLCVDVRDGRFHNGNAIQLWPCKSNTDANQLWTLKRDNTIRSNGKCLTTYGYSPGVYVMIYDCNTAATDATRWQIWDNGTIINPRSSLVLAATSGNSGTTLTVQTNIYAVSQGWLPTNNTQPFVTTIVGLYGLCLQANSGQVWIEDCSSEKAEQQWALYADGSIRPQQNRDNCLTSDSNIRETVVKILSCGPASSGQRWMFKNDGTILNLYSGLVLDVRASDPSLKQIILYPLHGDPNQIWLPLF,negative +GGGAGACAAGAATAAACGCTCAACAGAGAAGAAGCACCGATGCAACGCGAAAAGCACACGGCCTTCGACAGGAGGCTCACAACAGGC,MDHLNEATQGKEHSEMSNNVSDPKGPPAKIARLEQNGSPLGRGRLGSTGAKMQGVPLKHSGHLMKTNLRKGTMLPVFCVVEHYENAIEYDCKEEHAEFVLVRKDMLFNQLIEMALLSLGYSHSSAAQAKGLIQVGKWNPVPLSYVTDAPDATVADMLQDVYHVVTLKIQLHSCPKLEDLPPEQWSHTTVRNALKDLLKDMNQSSLAKECPLSQSMISSIVNSTYYANVSAAKCQEFGRWYKHFKKTKDMMVEMDSLSELSQQGANHVNFGQQPVPGNTAEQPPSPAQLSHGSQPSVRTPLPNLHPGLVSTPISPQLVNQQLVMAQLLNQQYAVNRLLAQQSLNQQYLNHPPPVSRSMNKPLEQQVSTNTEVSSEIYQWVRDELKRAGISQAVFARVAFNRTQGLLSEILRKEEDPKTASQSLLVNLRAMQNFLQLPEAERDRIYQDERERSLNAASAMGPAPLISTPPSRPPQVKTATIATERNGKPENNTMNINASIYDEIQQEMKRAKVSQALFAKVAATKSQGWLCELLRWKEDPSPENRTLWENLSMIRRFLSLPQPERDAIYEQESNAVHHHGDRPPHIIHVPAEQIQQQQQQQQQQQQQQQAPPPPQPQQQPQTGPRLPPRQPTVASPAESDEENRQKTRPRTKISVEALGILQSFIQDVGLYPDEEAIQTLSAQLDLPKYTIIKFFQNQRYYLKHHGKLKDNSGLEVDVAEYKEEELLKDLEESVQDKNTNTLFSVKLEEELSVEGNTDINTDLKD,negative +GGGAGAGCGAAGCGUGCUGGGCUGCUAUUUUGGCGUAAGCUGGUUUUUGGUGGUUGCGUUUUGAUCAUAACCCAGAGGUCGAUGGAUCC,MLNQLDNLTERVRGSNKLVDRWLHVRKHLLVAYYNLVGIKPGKESYMRLNEKALDDFCQSLVDYLSAGHFSIYERILHKLEGNGQLARAAKIWPQLEANTQQIMDYYDSSLETAIDHDNYLEFQQVLSDIGEALEARFVLEDKLILLVLDAARVKHPA,negative +CCAGAUUGUCCCCCACCAGAAGUGCAAUGC,MAWYWWRRRRRRGWWKPRRRRWRRRRARRRGPARRHRARRRIVRHPCNGQTSSGNRVPRSVQAVDPKYVSLQLVWHSWDFRRGLFGQAGIKRMQQESDALTLSPVHRPKRPKRDTQVKEKTPEKDSDSAVQLRRLQPWIHSSQETKDEEEEIPEGPVQEQLLQQLQQQRLLRVQLESIAQEVLKIRRGHSLHPLLSSHA,negative +CAAGGCAGAAUGUAAUGCUGAAUAAGAGAGAAAAGUGUUGGUGAGUGUAG,MIPPPRRSASSTPKDYRSSRDLQPWRGVSSGDAAETSQQSRHRRDAIADGGGRLKGAAQSSPSSGTRRSGPYAQGRAMPKNENIPKPGKQRLGPRKKKLSTLKKKILLDRLERWRDKQHEGALSTPSATASSEEAKCNNPFPLCPPGELSPPPSPPATICPAVVDKSTSYGQVGGANGERSVWAITIYNLVDQEDVEDDDDHAEIERDLWDMSSAFGVVRSVQVPRGTAVQVSDAEVSAAAAAGEPAAVAAKVAFATNAEAECARDGLNGRIVGGKPLLVRIHRCDGHFCGGVCPGDPDGSGLWRVAIENLIDEEDDLDDEDEYAEISANVSAMMGCYGKLVDVQVRRSSPSKGEVQEDVATRAATTAGATQAVVVTFGSLAEAEACVQGIKGCRVGGKELDAHVVLDSERVLPSNPAFKCDQEHAHSSDVAAAVAGQGDSMMKQEAGTEPSPCVDQDTAAAVASSTEWRVVIRGLIDEDDLQDDDDDYAEVCSDVTALVSSYGAVVGLDIPRGRETGSCCYGAEPGEAVVVFRSLQEAEACARGLSGRKVAGNILDAQVLTQPAPSQQGPLQGGASGTGPPVANRERKPAKECPLPQHQASSHQSCGKVPELDGSGPGMLRGFGNRVEDCCGRPKIACTDSDEPQAIAAAAPPGQSIEGPKTTALAKAGKRIQTKYQEAAALPKPPGVRGGLPNAYVNQPPDKEVNDLVFEMLQLLFKFQERARLSDPSKAKTRRRLVIGLREVLRGVKAKKVRLLIVAPNVDAVGGEGGLDDKVVEIIDKAREAEYPVVFALSKRKIGKALGKTIKVSAVGVYSFDGANEQQKQLKRRMETISSLPSPSPRQSDPPTDDALASPPSSSACGDSQDPAGKGSRV,negative +GGGAGAAGGGAAGTAACAGGAGCAUUAGCUACCAAGGGGUCGGGUUGUGGGUGAGAAGAGGTGACGGTACCAG,MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYTFLLPEMDNCRSSSSPYVSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQDNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVLVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF,negative +AGAAGAAUGCAGGAAACAGCGAAAUGCGUGUGGC,PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGKISKIGPENPYNTPVFAIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDESFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPXRXKNPEMVIYQYMDDLYVGSDLEIGQHRAKIEELRSHLLSWGFTTPDKKHQKEPPFLWMGYELHPDSWTVQPIELPEKDSWTVNE,negative +CTTCTGCCCGCCTCCTTCCTTTTTGCTGATCTCGGGTTTGGACTCCTGTTTATTTATAAGGAGACGAGATAGGCGGACACT,MSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEMLDRHHTHFCPLEGESWQDFLRNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAFLCQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERETPTTDSMPPLLRQAIELFDHQGAEPAFLFGLELIICGLEKQLKCESGS,negative +AGCAACCU,MAAGTAVGAWVLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISIIEPGEEGPTAGSVGGSGLGTLALALGILGGLGTAALLIGVILWQRRQRRGEERKAPENQEEEEERAELNQSEEPEAGESSTGGP,negative +CACCUUAGACCUGUCCUCCAAGCGUGAGUUGCUGUGGCC,MEDDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKEEIAEVANEIESLGSTEERKNMQRNKQVAMGRKKFNMDPKKGIQFLIENGLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERDEFSIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNTGVFQSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIKNEPFKIPVWFFLQNLYESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEDWIKCIKAAISRDPFYEMLAARKKKVSSTKRH,negative +GGGAGAATTCCGACCAGAAGGCTTGCTGTTGTTTCCCTGTTGTTTTGTCTCTCAACTTTATTGTGGTAAAGATCACTGGGTTGATAAGGGCTAACTCTAATTTGACTACATGG,MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP,negative +CUCAGAGACAGAGCAGAAACGACAGUUCAAGCCGAA,MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH,negative +TCCGATAAGTATGTGACAACCTACAAAGCACTCCACGCCT,MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA,negative +AGCGCGCACCTACTGTGATGCAGAAGTCACAGCAAGGCCC,MDKLVVNYYEYKHPIINKDLAIGAHGGKKFPTLGAWYDVINEYEFQTRCPIILKNSHRNKHFTFACHLKNCPFKVLLSYAGNAASSETSSPSANNNTNPPGTPDHIHHHSNNMNNEDNDNNNGSNNKVSNDSKLDFVTDDLEYHLANTHPDDTNDKVESRSNEVNGNNDDDADANNIFKQQGVTIKNDTEDDSINKASIDRGLDDESGPTHGNDSGNHRHNEEDDVHTQMTKNYSDVVNDEDINVAIANAVANVDSQSNNKHDGKDDDATNNNDGQDNNTNNDHNNNSNINNNNVGSHGISSHSPSSIRDTSMNLDVFNSATDDIPGPFVVTKIEPYHSHPLEDNLSLGKFILTKIPKILQNDLKFDQILESSYNNSNHTVSKFKVSHYVEESGLLDILMQRYGLTAEDFEKRLLSQIARRITTYKARFVLKKKKMGEYNDLQPSSSSNNNNNNDGELSGTNLRSNSIDYAKHQEISSAGTSSNTTKNVNNNKNDSNDDNNGNNNNDASNLMESVLDKTSSHRYQPKKMPSVNKWSKPDQITHSDVSMVGLDESNDGGNENVHPTLAEVDAQEARETAQLAIDKINSYKRSIDDKNGDGHNNSSRNVVDENLINDMDSEDAHKSKRQHLSDITLEERNEDDKLPHEVAEQLRLLSSHLKEVENLHQNNDDDVDDVMVDVDVESQYNKNTTHHNNHHSQPHHDEEDVAGLIGKADDEEDLSDENIQPELRGQ,negative +CTTCTGCCCGCCTCCTTCCGTGGGGATGCCATTGGTCCACAGGGTTATGGGAGCATCAGGAGACGAGATAGGCGGACACT,MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS,negative +GGGAGACAAGAATAAACGCTCAAAAACTGATGGAAAATGTGGGGCTGGTGTGACTTAGGGCCTTCGACAGGAGGCTCACAACAGGC,MASTSRLDALPRVTCPNHPDAILVEDYRAGDMICPECDRVIDVGSEWRTFSNDKATKDPSRVGDSQNPLLSDGDLSTMIGKGTGAASFDEFGNSKYQNRRTMSSSDRAMMNAFKEITTMADRINLPRNIVDRTNNLFKQVYEQKSLKGRANDAIASACLYIACRQEGVPRTFKEICAVSRISKKEIGRCFKLILKALETSVDLITTGDFMSRFCSNLCLPKQVQMAATHIA,negative +CAUGAGGUCGUAUGCGAUCUGCAUCGACAGCUAGGCGGAGCUAUCG,LLNGSLAEEIVIRTENIADNTKDIIVQFNKTVSIACTRPHNNTRRGIHIGPGQAFYATGDIIGDIRQAHCNVSGENWTETMEWVKAKLEKTFNVTNITFEPPITGGDLEITTHSFNCRGEFFYCNTSKLFNSSELNSIKGKENYTIILPCRIKQFVRMWQRVGQAMYAPPIEGNITCISNITGLILTRDGGINRTNDTFRPGGGDMRDNWRRKL,negative +TACGTGAGCGTGCTGTCCCCTAAAGGTGATACGTC,MSMSPKHTTPFSVSDILSPLEESYKKVGMEGGGLGAPLAAYRQGQAAPPAAAMQQHAVGHHGAVTAAYHMTAAGVPQLSHSAVGGYCNGNLGNMSELPPYQDTMRNSASGPGWYGANPDPRFPAISRFMGPASGMNMSGMGGLGSLGDVSKNMAPLPSAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGGGGGGGAGCPQQQQAQQQSPRRVAVPVLVKDGKPCQAGAPAPGAGSLQGHAQQQAQQQAQAAQAAAAAISVGSGGPGLGAHPGHQPGSAGQSPDLAHHAASPAALQGQVSSLSHLNSSGSDYGTMSCSTLLYGRTW,negative +UAUGUUGUGUGUGUGUUGUUUUUGUGUUUUGUUUU,MAMQMQLEANADTSVEEESFGPQPISRLEQCGINANDVKKLEEAGFHTVEAVAYAPKKELINIKGISEAKADKILAEAAKLVPMGFTTATEFHQRRSEIIQITTGSKELDKLLQGGIETGSITEMFGEFRTGKTQICHTLAVTCQLPIDRGGGEGKAMYIDTEGTFRPERLLAVAERYGLSGSDVLDNVAYARAFNTDHQTQLLYQASAMMVESRYALLIVDSATALYRTDYSGRGELSARQMHLARFLRMLLRLADEFGVAVVITNQVVAQVDGAAMFAADPKKPIGGNIIAHASTTRLYLRKGRGETRICKIYDSPCLPEAEAMFAINADGVGDAKD,negative +GAGGCUGAUGGCAGACGCCGGCCGAAGACA,MAITKINDCFELLSMVTYADKLKSLIKKEFSISFEEFAVLTYISENKEKEYYLKDIINHLNYKQPQVVKAVKILSQEDYFDKKRNEHDERTVLILVNAQQRKKIESLLSRVNKRITEANNEIEL,negative +AGUAAUACGACUCACUAUAGGGAGAAUUCCGACCAGAAGGGUUAGCGGUCGUCUUAAGUAGUUUUUGGUCCUUUCCUCUCUCCUUCCUCUUCU,MKQYLNTVISNPRPAQALGINQPFVVFCFITSRALSFVPAIYWCFKCLHLAFVADKFKWLPLTSALWTLVSAYLSFVLANGFLLKWLIHYSIGPTIIRLFSLNVINFSFLSLSVSFITHGDNAYLLPAWIAISCFQTAAYIVQDWITSPIIRTLPFRSSSSSSSNYRHNLDFLEITVFAVVPVGIASFFTMVMLIWQLYKYPDSFLVSA,negative +NGACUGAUUUUUCCUUGNCAGUGUAAUUUCCUGGCUGCCC,MRKIVVAAIAVSLTTVSITASASADPSKDSKAQVSAAEAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKVKPSAASIDAAKKAGVNNGNPLDAVQQ,negative +GGCGAGAACAGGTCGTCCGAGGGTGACCCAACAAGGAAAA,MTPDIQAPFLSLLLLFPVLTVANVPTLTTSDSINPRRTTPVSTTQSSPTSSPTKETSWSTTTTLLTASSPAPSPAASPGHDGASTPTSSPAPSPAASPGHDGASTPTSSPAPSPAASPGHDGASTPTSSPAPSPAASPGHDGASTPTSSPAPSPAASPGHNGTSSPTGSPAPSPAASPGHDGASTPTSSPAPSPAASPGHNGTSSPTGSPAPSPAASPGHDGASTPTSSPAPSPAASPGHNGTSSPTGSPAPSPTASPGHDSAPSLTSSPAPSPTASPGQHGASSPTSSDTSSMTTRSMSSSMVTSAHKGTSSRATMTPVSKGTPSSVPSSETAPTAASHITRTAASSPSIALSTSSNPKTSQQLSVRVSLYFLSFRITNLQFNSSLENPQTSYYQELQRSIWGLILQIYKQRDFLGLSEIKFRPGSVVVELTLAFREGTTAEWVKAQFSQLEAHAASYNLTISGVSVYSAPFPSSAQAGSGVPGWGIALLVLVCVLVALAIIYLIALVVCQCGRKKCEQLDVFPTLDAYHPMSEYSTYHTHGRYVPPGSTKRSPYEEVSAGNGGSNLSYTNLAATSANL,negative +CAGCTCAGAAGCTTGATCCTGTGCGGGCGGCAAGGCCCTGACAGAGATACTGGCTCGGGACTCGAAGTCGTGCATCTGCA,MGCRRTREGPSKAMIFPWKCQSTQRDLWNIFKLWGWTMLCCDFLAHHGTDCWTYHYSEKPMNWQRARRFCRDNYTDLVAIQNKAEIEYLEKTLPFSRSYYWIGIRKIGGIWTWVGTNKSLTEEAENWGDGEPNNKKNKEDCVEIYIKRNKDAGKWNDDACHKLKAALCYTASCQPWSCSGHGECVEIINNYTCNCDVGYYGPQCQFVIQCEPLEAPELGTMDCTHPLGNFSFSSQCAFSCSEGTNLTGIEETTCGPFGNWSSPEPTCQVIQCEPLSAPDLGIMNCSHPLASFSFTSACTFICSEGTELIGKKKTICESSGIWSNPSPICQKLDKSFSMIKEGDYNPLFIPVAVMVTAFSGLAFIIWLARRLKKGM,negative +ACTCGAACATTTCCACTAACCAACCATACTAAAGCACCGC,MLNQLDNLTERVRGSNKLVDRWLHVRKHLLVAYYNLVGIKPGKESYMRLNEKALDDFCQSLVDYLSAGHFSIYERILHKLEGNGQLARAAKIWPQLEANTQQIMDYYDSSLETAIDHDNYLEFQQVLSDIGEALEARFVLEDKLILLVLDAARVKHPA,negative +AUCGCCCUGAACCGGCCCAGCAGACUGCUGACGGCACGAU,MNQTAILICCLIFLTLSGIQGVPLSRTVRCTCISISNQPVNPRSLEKLEIIPASQFCPRVEIIATMKKKGEKRCLNPESKAIKNLLKAVSKERSKRSP,negative +UGACCAAGCCUCACGUUGAACCUGCCAGUAGACCCCGCCCA,MGCRRTREGPSKAMIFPWKCQSTQRDLWNIFKLWGWTMLCCDFLAHHGTDCWTYHYSEKPMNWQRARRFCRDNYTDLVAIQNKAEIEYLEKTLPFSRSYYWIGIRKIGGIWTWVGTNKSLTEEAENWGDGEPNNKKNKEDCVEIYIKRNKDAGKWNDDACHKLKAALCYTASCQPWSCSGHGECVEIINNYTCNCDVGYYGPQCQFVIQCEPLEAPELGTMDCTHPLGNFSFSSQCAFSCSEGTNLTGIEETTCGPFGNWSSPEPTCQVIQCEPLSAPDLGIMNCSHPLASFSFTSACTFICSEGTELIGKKKTICESSGIWSNPSPICQKLDKSFSMIKEGDYNPLFIPVAVMVTAFSGLAFIIWLARRLKKGM,negative +CGTACCAAGATCCCACAACTAGCCGACCACAATTGCCGGC,MSGGDGRGHNTGAHSTSGNINGGPTGLGVGGGASDGSGWSSENNPWGGGSGSGIHWGGGSGHGNGGGNGNSGGGSGTGGNLSAVAAPVAFGFPALSTPGAGGLAVSISAGALSAAIADIMAALKGPFKFGLWGVALYGVLPSQIAKDDPNMMSKIVTSLPADDITESPVSSLPLDKATVNVNVRVVDDVKDERQNISVVSGVPMSVPVVDAKPTERPGVFTASIPGAPVLNISVNNSTPAVQTLSPGVTNNTDKDVRPAGFTQGGNTRDAVIRFPKDSGHNAVYVSVSDVLSPDQVKQRQDEENRRQQEWDATHPVEAAERNYERARAELNQANEDVARNQERQAKAVQVYNSRKSELDAANKTLADAIAEIKQFNRFAHDPMAGGHRMWQMAGLKAQRAQTDVNNKQAAFDAAAKEKSDADAALSSAMESRKKKEDKKRSAENNLNDEKNKPRKGFKDYGHDYHPAPKTENIKGLGDLKPGIPKTPKQNGGGKRKRWTGDKGRKIYEWDSQHGELEGYRASDGQHLGSFDPKTGNQLKGPDPKRNIKKYL,negative +GAACGACCACCGCTACCGACTACGCCATAAACTGCCCGG,MSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEMLDRHHTHFCPLEGESWQDFLRNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAFLCQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERETPTTDSMPPLLRQAIELFDHQGAEPAFLFGLELIICGLEKQLKCESGS,negative +GUUCCAGGCGCGUUAGCAAAACCGCGGAUC,MEDLVVEVRGSNGAFYKAFVKDVHEDSITVAFENNWQPDRQIPFHDVRFPPPVGYNKDINESDEVEVYSRANEKEPCCWWLAKVRMIKGEFYVIEYAACDATYNEIVTIERLRSVNPNKPATKETFHKIKLDVPEDLRQMCAKESAHKDFKKAVGAFSVTYDPENYQLVVLSISEVTSKRAHMLIDMHFRSLRTKLSLILRNEEASKQLESSRQLASRFHEQFVVREDLMGLAIGTHGANIQQARKVPGVTAIDLDEDTCTFHIYGEDQDAVKKARSFLEFAEDVIQVPRNLVGKVIGKKKKK,negative +TGTATCGTATTTGGTGATGTTTGGTGTTCA,MSARGEEAAGEASGSQEQPEPALAEPKKRGPGRPRKPQQEPTGEPVPKRPRGRPKGSKNKGPSKAAQKKAETTGEKRPRGRPRKWPQQVVQEKPAQEEEEEEEEEEAEED,negative +UACCGAAAACGCAUGCCUCUAGCCGUUCGAUACGAGCUGAGCAGCGGGCCAGUACUACAAGCUUCUGGACUCGGU,MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC,negative +GGGCCGTTCGAACCGAGCATGGATCGAGGATGGGAACACCCAGTAGGAGGATGGGCATGGCCGGACCCAAAATTAGCAGTGGGACAGTACTCAGGTCATCCTAGG,QDRPIKFSTEGATSQSYKQFIEALRERLRGGLIHDIPVLPDPTTLQERNRYITVELSNSDTESIEVGIDVTNAYVVAYRAGTQSYFLRDAPSSASDYLFTGTDQHSLPFYGTYGDLERWAHQSRQQIPLGLQALTHGISFFRSGGNDNEEKARTLIVIIQMVAEAARFRYISNRVRVSIQTGTAFQPDAAMISLENNWDNLSRGVQESVQDTFPNQVTLTNIRNEPVIVDSLSHPTVAVLALMLFVCNPPNANQSPLLIRSIVEKSKICSSRYEPTVRIGGRDGMCVDVYDNGYHNGNRIIMWKCKDRLEENQLWTLKSDKTIRSNGKCLTTYGYAPGSYVMIYDCTSAVAEATYWEIWDNGTIINPKSALVLSAESSSMGGTLTVQTNEYLMRQGWRTGNNTSPFVTSISGYSDLCMQAQGSNVWMADCDSNKKEQQWALYTDGSIRSVQNTNNCLTSKDHKQGSTILLMGCSNGWASQRWVFKNDGSIYSLYDDMVMDVKGSDPSLKQIILWPYTGKPNQIWLTLF,negative +GAAUCAAUACACAGUCCUGGGUGCUAACCAUGAACACCCAAGGCCUUAGUGGUAUGUGGUUAUUG,MEGMLKGEGPGPLPPLLQQYVELRDQYPDYLLLFQVGDFYECFGEDAERLARALGLVLTHKTSKDFTTPMAGIPLRAFEAYAERLLKMGFRLAVADQVEPAEEAEGLVRREVTQLLTPGTLLQESLLPREANYLAAIATGDGWGLAFLDVSTGEFKGTVLKSKSALYDELFRHRPAEVLLAPELLENGAFLDEFRKRFPVMLSEAPFEPEGEGPLALRRARGALLAYAQRTQGGALSLQPFRFYDPGAFMRLPEATLRALEVFEPLRGQDTLFSVLDETRTAPGRRLLQSWLRHPLLDRGPLEARLDRVEGFVREGALREGVRRLLYRLADLERLATRLELGRASPKDLGALRRSLQILPELRALLGEEVGLPDLSPLKEELEAALVEDPPLKVSEGGLIREGYDPDLDALRAAHREGVAYFLELEERERERTGIPTLKVGYNAVFGYYLEVTRPYYERVPKEYRPVQTLKDRQRYTLPEMKEKEREVYRLEALIRRREEEVFLEVRERAKRQAEALREAARILAELDVYAALAEVAVRYGYVRPRFGDRLQIRAGRHPVVERRTEFVPNDLEMAHELVLITGPNMAGKSTFLRQTALIALLAQVGSFVPAEEAHLPLFDGIYTRIGASDDLAGGKSTFMVEMEEVALILKEATENSLVLLDEVGRGTSSLDGVAIATAVAEALHERRAYTLFATHYFELTALGLPRLKNLHVAAREEAGGLVFYHQVLPGPASKSYGVEVAAMAGLPKEVVARARALLQAMAARREGALDAVLERLLALDPDRLTPLEALRLLQELKALALGAPLDTMKG,negative +GGCTGTTGTGAGCCTCCTCCCAGAGGGAAGACTTTAGGTTCGGTTCACGTCCCGCTTATTCTTACTCCC,MKPTAMALMCLLLAAVWIQDVDSKSMLTVSNSCCLNTLKKELPLKFIQCYRKMGSSCPDPPAVVFRLNKGRESCASTNKTWVQNHLKKVNPC,negative +GAAUCAAUACACAGUCCUGGGUGCUAACCAUGAACACCCAAGGCCUUAGUGGUGUGUGGUCCCUG,MAWYWWRRRRRRGWWKPRRRRWRRRRARRRGPARRHRARRRIVRHPCNGQTSSGNRVPRSVQAVDPKYVSLQLVWHSWDFRRGLFGQAGIKRMQQESDALTLSPVHRPKRPKRDTQVKEKTPEKDSDSAVQLRRLQPWIHSSQETKDEEEEIPEGPVQEQLLQQLQQQRLLRVQLESIAQEVLKIRRGHSLHPLLSSHA,negative +UAUCCUCCAGAGCAUCGCCGUCCAUAACCACUUACCUCCU,MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA,negative +GUAGUCAAAAGUCAUACAGCUCUACCAACAGCUCGA,MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINYDEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQAVAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQGIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADMDFSALLSQISS,negative +ATGGCTGTGGTGGAGGGCCGAAGCCTGTACAAAACAGGAATGCGCTTATCTTGGAGTAT,MVKSHIGSWILVLFVAMWSDVGLCKKRPKPGGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGTHGQWNKPSKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGSDYEDRYYRENMHRYPNQVYYRPVDQYSNQNNFVHDCVNITVKEHTVTTTTKGENFTETDIKMMERVVEQMCITQYQRESQAYYQRGASVILFSSPPVILLISFLIFLIVG,negative +UGGUAGGACGGCACCGGAGAAAGGUAGCAUGAUAAGCGAGUACCUGCCGU,MSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA,negative +GAGCCAGUAAGUGACCCGUACUAAUACUGUUGAGUAGUAUGUAGAGGAGUGGUGAUCCUCCAAACUGCUG,MDSTNYISKLFEYAQRQGQISDIKFEEVGTDGPDHLKTFTLRVVIKGHAYPNGVGKTKKEAKRNAAKHALIGMMETTEQKDASVSCPPSPAPSPAPPVRAVISQPKYVSWLNEHSQKNKLSLKALEGARVGPNNTSQCCRYVVGEKEYPEGFGNTKKEAKEEAAMQVYLELCGGSQTTGTVDENCNGTTGKHKEELNGKVVVLSEKVEHMNMSPAQNVPEQYSFITTEETNFIGILNHYCQKTKRFLDFKLVEKSGPSHNPQFVYKVLIDKREYPDGLGKTAKEAKQQAAQLAWSALQEQSDWNSQVSCRSTVSEEGGLSSLTPSSTWESQDATPSSLSIAGSTSESIIFSDSVNVSSPKDESPVNVKPKIRLAANFQMSPVKTKQEGPNLKGNDLGTLSSGRTSNQPVISRFSSEFDSIENIGKGGFGHVYKARRKLEQKYFAVKIVRSKGKAKREVGALADLQHPNIVRYYTAWLEDTAYRCDTASESDTTSDSGSSSSSEFLYIQMELCDKRTLKVWIDERNAHRKPKRREESLSITQQIVNGVEYIHSKKLLHRDLKPANIMFGMSDGEGKGEVKIGDFGLVTAEDNDNDENLLERTKKTGTVSYMAPEQRNQTSYDRKVDIFALGLIYFEPLWDLSGMEKAKVWNDVRSQRFPQQFNSQFTLENKVIESLLCANPEERPDARQLKTKLNECSRVLTRVHNIHQDNRTI,negative +GGGAGAAUUCAACUGCCAUCUAUAGAGAUGAAGCCAAGCUUCUUUCCCUUAUGGGCCCGUAAACCGAGUCCAGAAGCUUGUAGU,MLDLFADAEPWQEPLAAGAVILRRFAFNAAEQLIRDINDVASQSPFRQMVTPGGYTMSVAMTNCGHLGWTTHRQGYLYSPIDPQTNKPWPAMPQSFHNLCQRAATAAGYPDFQPDACLINRYAPGAKLSLHQDKDEPDLRAPIVSVSLGLPAIFQFGGLKRNDPLKRLLLEHGDVVVWGGESRLFYHGIQPLKAGFHPLTIDCRYNLTFRQAGKKE,negative +TCCCACGCATTCTCCACATCTAGTCTGGTTACGGTCTCGATTGTCCCAAAAGGGCAGACACCTTTCTGTCCTTCCGTCAC,PHITDVVLDKANKTPLRQLDPSRLPDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFAKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRQSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPINRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDTASEATRPATLNRFSALQQTLPAENTDNRRVVQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRTRTPATKRSFSKEVEERSRERPSQPEGLRKAASLTEDRGRDPVKREATLPPVSPPKAALSVDEVEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRLGIESTLERSTIAREHMGRLLHQLLCAGHLSTAQYYQGLYETLELAEDMEIDIPHVWLYLAELITPILQEDGVPMGELFREITKPLRPMGKATSLLLEILGLLCKSMGPKKVGMLWREAGLSWREFLAEGQDVGSFVAEKKVEYTLGEESEAPGQRTLAFEELRRQLEKLLKDGGSNQRVFDWIDANLNEQQIASNTLVRALMTTVCYSAIIFETPLRVDVQVLKVRARLLQKYLCDEQKELQALYALQALVVTLEQPANLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFNWLREAEDEESDHN,negative +TTATGGGGATGAAAGTGGTGTTCGGGTTCGCCACTTCCAC,MVKSHIGSWILVLFVAMWSDVGLCKKRPKPGGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGSHSQWNKPSKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGNDYEDRYYRENMYRYPNQVYYRPVDRYSNQNNFVHDCVNITVKQHTVTTTTKGENFTETDIKIMERVVEQMCITQYQRESQAYYQRGASVILFSSPPVILLISFLIFLIVG,negative +GTAGATTGAATTAATTGGAAGAGTCGATCAGTGTTTAATG,MAVAQELYGFPASKLDSFVAQWLQPTREWKEEVLETVQTVEQFLRQENFREDRGPARDVRVLKVLKVGCFGNGTVLRSTTDVELVVFLSCFHSFQEEAKHHQAVLRLIQKRMYYCQELMDLGLSNLSVTNRVPSSLIFTIQTRETWETITVTVVPAYRALGPSCPSSEVYANLIKANGYPGNFSPSFSELQRNFVKHRPTKLKSLLRLVKHWYQQYVRDKCPRANLPPLYALELLTVYAWEAGTREDANFRLDEGLATVMELLQDHELLCIYWTKHYTLQHPVIEACVRRQLRGQRPIILDPADPTNNVAEGYRWDIVAQRANQCLKQDCCYDNRDSPVPSWRVKRAPDIQVTVQEWGHSDLTFWVNPYEPIKKLKEKIQLSQGYLGLQRLSFQEPGGERQLIRSHCTLAYYGIFCDTHICLLDTISPEIQVFVKNPDGRSHAYAIHPLDYVLNLKQQIEDRQGLRCQEQRLEFQGHILEDWFDFKSYGIQDSVTVILSKTTEGAAPFVPS,negative +GUAUAUAGUAUAGUAUUGGC,MANLGYWLLALFVTMWTDVGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGTWGQPHGGGWGQPHGGSWGQPHGGSWGQPHGGGWGQGGGTHNQWNKPSKPKTNLKHVAGAAAAGAVVGGLGGYMLGSAMSRPMIHFGNDWEDRYYRENMYRYPNQVYYRPVDQYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCVTQYQKESQAYYDGRRSSSTVLFSSPPVILLISFLIFLIVG,negative +UCGGAGGUGGUUCAGCUCUGCAUCGACAGUUGGC,MGCRRTREGPSKAMIFPWKCQSTQRDLWNIFKLWGWTMLCCDFLAHHGTDCWTYHYSEKPMNWQRARRFCRDNYTDLVAIQNKAEIEYLEKTLPFSRSYYWIGIRKIGGIWTWVGTNKSLTEEAENWGDGEPNNKKNKEDCVEIYIKRNKDAGKWNDDACHKLKAALCYTASCQPWSCSGHGECVEIINNYTCNCDVGYYGPQCQFVIQCEPLEAPELGTMDCTHPLGNFSFSSQCAFSCSEGTNLTGIEETTCGPFGNWSSPEPTCQVIQCEPLSAPDLGIMNCSHPLASFSFTSACTFICSEGTELIGKKKTICESSGIWSNPSPICQKLDKSFSMIKEGDYNPLFIPVAVMVTAFSGLAFIIWLARRLKKGM,negative +CGCCGTATTAAGATTGGGAGACCTGGTAGA,MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA,negative +CTATAGAGGTGCTCCAGGGCGATAAACTTATGAATATTAA,MEPVDPRLEPWKHPGSQPKTACTNCYCKKCCFHCQVCFITKALGISYGRKKRRQRRRAHQNSQTHQASLSKQPTSQPRGDPTGPKE,negative +AAAAAAAAAAAAAAA,MAGPQALAFGLLLAVVTATLAAAQRDCVCDNYKLATSCSLNEYGECQCTSYGTQNTVICSKLASKCLAMKAEMTHSKSGRRIKPEGAIQNNDGLYDPDCDEQGLFKAKQCNGTATCWCVNTAGVRRTDKDTEITCSERVRTYWIIIELKHKERESPYDHQSLQTALQEAFTSRYKLNQKFIKNIMYENNVITIDLMQNSSQKTQDDVDIADVAYYFEKDVKGESLFHSSKSMDLRVNGEPLDLDPGQTLIYYVDEKAPEFSMQGLTAGIIAVIVVVSLAVIAGIVVLVISTRKKSAKYEKAEIKEMGEIHRELNA,negative +UCCAAACCCCGUUGAGAGUUGAUCCGGUCUAGGGAAUGGAAAGAAGUAGGUAUCGAAGAGAAUGUACCCU,MSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEMLDRHHTHFCPLEGESWQDFLRNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAFLCQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERETPTTDSMPPLLRQAIELFDHQGAEPAFLFGLELIICGLEKQLKCESGS,negative +TATTAGCAACAATATTAGCAACAA,LQENFLPQPRQQHHGTLVLHYRPHREEAGMQHPCLWPGSSHCSDDSTLRRLQCESVTSIGAVCP,negative +GGGAGCTCAGAATAAACGCTCAAAATGCGGGGTGGGTGGGGTGGTTGAAGAATATTCGACATGAGGCCCGGATC,MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYTFLLPEMDNCRSSSSPYVSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQDNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVLVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF,negative +GGGAGAGGAGAGAACGUUCUACAGCGCCGGUGGGCGGGCAUUGGGUGGAUGCGCUGUCGAUCGAUCGAUCGAUG,MGVLLTQRTLLSLVLALLFPSMASMAAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQGLDVPKLREHCRERPGAFPSEETLRGLGRRGFLQTLNATLGCVLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILGLRNNIYCMAQLLDNSDTAEPTKAGRGASQPPTPTPASDAFQRKLEGCRFLHGYHRFMHSVGRVFSKWGESPNRSRRHSPHQALRKGVRRTRPSRKGKRLMTRGQLPR,negative +GGTTGGTATGGTTGG,MTPDIQAPFLSLLLLFPVLTVANVPTLTTSDSINPRRTTPVSTTQSSPTSSPTKETSWSTTTTLLTASSPAPSPAASPGHDGASTPTSSPAPSPAASPGHDGASTPTSSPAPSPAASPGHDGASTPTSSPAPSPAASPGHDGASTPTSSPAPSPAASPGHNGTSSPTGSPAPSPAASPGHDGASTPTSSPAPSPAASPGHNGTSSPTGSPAPSPAASPGHDGASTPTSSPAPSPAASPGHNGTSSPTGSPAPSPTASPGHDSAPSLTSSPAPSPTASPGQHGASSPTSSDTSSMTTRSMSSSMVTSAHKGTSSRATMTPVSKGTPSSVPSSETAPTAASHITRTAASSPSIALSTSSNPKTSQQLSVRVSLYFLSFRITNLQFNSSLENPQTSYYQELQRSIWGLILQIYKQRDFLGLSEIKFRPGSVVVELTLAFREGTTAEWVKAQFSQLEAHAASYNLTISGVSVYSAPFPSSAQAGSGVPGWGIALLVLVCVLVALAIIYLIALVVCQCGRKKCEQLDVFPTLDAYHPMSEYSTYHTHGRYVPPGSTKRSPYEEVSAGNGGSNLSYTNLAATSANL,negative +CCCCCAUGGCACGCCGAUCACGUUUUGCUGUCCGCCGGUCCAUAAAUACU,MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA,negative +CAAGGCAGAAUGUAAUGCUGAAUAAGAGAGAAAAGUGUUGGUGAG,MTSHYVIAIFALMSSCLATAGPEPGALCELSPVSASHPVQALMESFTVLSGCASRGTTGLPQEVHVLNLRTAGQGPGQLQREVTLHLNPISSVHIHHKSVVFLLNSPHPLVWHLKTERLATGVSRLFLVSEGSVVQFSSANFSLTAETEERNFPHGNEHLLNWARKEYGAVTSFTELKIARNIYIKVGEDQVFPPKCNIGKNFLSLNYLAEYLQPKAAEGCVMSSQPQNEEVHIIELITPNSNPYSAFQVDITIDIRPSQEDLEVVKNLILILKCKKSVNWVIKSFDVKGSLKIIAPNSIGFGKESERSMTMTKSIRDDIPSTQGNLVKWALDNGYSPITSYTMAPVANRFHLRLENNAEEMGDEEVHTIPPELRILLDPGALPALQNPPIRGGEGQNGGLPFPFPDISRRVWNEEGEDGLPRPKDPVIPSIQLFPGLREPEEVQGSVDIALSVKCDNEKMIVAVEKDSFQASGYSGMDVTLLDPTCKAKMNGTHFVLESPLNGCGTRPRWSALDGVVYYNSIVIQVPALGDSSGWPDGYEDLESGDNGFPGDMDEGDASLFTRPEIVVFNCSLQQVRNPSSFQEQPHGNITFNMELYNTDLFLVPSQGVFSVPENGHVYVEVSVTKAEQELGFAIQTCFISPYSNPDRMSHYTIIENICPKDESVKFYSPKRVHFPIPQADMDKKRFSFVFKPVFNTSLLFLQCELTLCTKMEKHPQKLPKCVPPDEACTSLDASIIWAMMQNKKTFTKPLAVIHHEAESKEKGPSMKEPNPISPPIFHGLDTLTVMGIAFAAFVIGALLTGALWYIYSHTGETAGRQQVPTSPPASENSSAAHSIGSTQSTPCSSSSTA,negative +CAUAGGCUUACAACAGAGCGGGGGUUCUGAUGGUAGACGCCGGGACGCCC,MEDDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKEEIAEVANEIESLGSTEERKNMQRNKQVAMGRKKFNMDPKKGIQFLIENGLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERDEFSIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNTGVFQSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIKNEPFKIPVWFFLQNLYESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEDWIKCIKAAISRDPFYEMLAARKKKVSSTKRH,negative +CGAUACAGCACUGAUUGCGGUCGAGGUAGCUUGAUGGGCC,MANLGYWLLALFVTMWTDVGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGTWGQPHGGGWGQPHGGSWGQPHGGSWGQPHGGGWGQGGGTHNQWNKPSKPKTNLKHVAGAAAAGAVVGGLGGYMLGSAMSRPMIHFGNDWEDRYYRENMYRYPNQVYYRPVDQYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCVTQYQKESQAYYDGRRSSSTVLFSSPPVILLISFLIFLIVG,negative +GATGTGGGTGTAGTTGGAGGGTAAACGTT,MVKSHIGSWILVLFVAMWSDVGLCKKRPKPGGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGTHGQWNKPSKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGSDYEDRYYRENMHRYPNQVYYRPVDQYSNQNNFVHDCVNITVKEHTVTTTTKGENFTETDIKMMERVVEQMCITQYQRESQAYYQRGASVILFSSPPVILLISFLIFLIVG,negative +ACATGTGATGATATATCGTGTCTCGTGATA,MKKRKVLIPLMALSTILVSSTGNLEVIQAEVKQENRLLNESESSSQGLLGYYFSDLNFQAPMVVTSSTTGDLSIPSSELENIPSENQYFQSAIWSGFIKVKKSDEYTFATSADNHVTMWVDDQEVINKASNSNKIRLEKGRLYQIKIQYQRENPTEKGLDFKLYWTDSQNKKEVISSDNLQLPELKQKSSNSRKKRSTSAGPTVPDRDNDGIPDSLEVEGYTVDVKNKRTFLSPWISNIHEKKGLTKYKSSPEKWSTASDPYSDFEKVTGRIDKNVSPEARHPLVAAYPIVHVDMENIILSKNEDQSTQNTDSQTRTISKNTSTSRTHTSEVHGNAEVHASFFDIGGSVSAGFSNSNSSTVAIDHSLSLAGERTWAETMGLNTADTARLNANIRYVNTGTAPIYNVLPTTSLVLGKNQTLATIKAKENQLSQILAPNNYYPSKNLAPIALNAQDDFSSTPITMNYNQFLELEKTKQLRLDTDQVYGNIATYNFENGRVRVDTGSNWSEVLPQIQETTARIIFNGKDLNLVERRIAAVNPSDPLETTKPDMTLKEALKIAFGFNEPNGNLQYQGKDITEFDFNFDQQTSQNIKNQLAELNATNIYTVLDKIKLNAKMNILIRDKRFHYDRNNIAVGADESVVKEAHREVINSSTEGLLLNIDKDIRKILSGYIVEIEDTEGLKEVINDRYDMLNISSLRQDGKTFIDFKKYNDKLPLYISNPNYKVNVYAVTKENTIINPSENGDTSTNGIKKILIFSKKGYEIG,negative +GGGAGAGGAGGGAGAUAGAUAUCAAGAUAAAAACGCCGGCGUAGCGCUGCAGCGCAAAAAAACACGACUGCUCGCACGAGGUGACUCAGGCAGAGAAGGCGAGUUUCGUGGAUGCCACAGGAC,MASNFTQFVLVDNGGTGDVTVAPSNFANGVAEWISSNSRSQAYKVTCSVRQSSAQNRKYTIKVEVPKVATQTVGGVELPVAAWRSYLNMELTIPIFATNSDCELIVKAMQGLLKDGNPIPSAIAANSGIY,negative +CTTCTGCCCGCCTCCTTCCAGAGTAGCCAAGCGGAGAGTATTTTTGACTGCTTCCCCCGGAGACGAGATAGGCGGACACT,MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA,negative diff --git a/pyaptamer/utils/tag_checks.py b/pyaptamer/utils/tag_checks.py new file mode 100644 index 00000000..36eefb5a --- /dev/null +++ b/pyaptamer/utils/tag_checks.py @@ -0,0 +1,5 @@ +def task_check(estimator): + if estimator.task not in estimator._tags["tasks"]: + raise ValueError( + f"Invalid task '{estimator.task}'. Must be a {estimator._tags['tasks']}." + ) diff --git a/x.py b/x.py new file mode 100644 index 00000000..0fdc64ca --- /dev/null +++ b/x.py @@ -0,0 +1,4 @@ +from pyaptamer.datasets._loaders._pfoa_loader import load_pfoa_structure + +a = load_pfoa_structure() +print(a.id) From 98a3a1fb9c169b8d046f6799b8014f28a111e3e0 Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Tue, 2 Sep 2025 02:17:05 +0530 Subject: [PATCH 114/145] Initial setup --- examples/aptanet_tutorial.ipynb | 500 --------------------- pyaptamer/aptanet/_feature_classifier.py | 71 +-- pyaptamer/benchmarking/_base.py | 72 ++- pyaptamer/datasets/_loaders/_csv_loader.py | 37 ++ pyaptamer/utils/tag_checks.py | 5 - x.py | 5 +- 6 files changed, 120 insertions(+), 570 deletions(-) delete mode 100644 examples/aptanet_tutorial.ipynb create mode 100644 pyaptamer/datasets/_loaders/_csv_loader.py delete mode 100644 pyaptamer/utils/tag_checks.py diff --git a/examples/aptanet_tutorial.ipynb b/examples/aptanet_tutorial.ipynb deleted file mode 100644 index 285faa3e..00000000 --- a/examples/aptanet_tutorial.ipynb +++ /dev/null @@ -1,500 +0,0 @@ -{ - "cells": [ - { - "cell_type": "markdown", - "id": "50e8d179", - "metadata": {}, - "source": [ - "# Binding prediction using AptaNet\n", - "Step-by-step guide to using AptaNet for binary aptamer–protein binding prediction." - ] - }, - { - "cell_type": "markdown", - "id": "40a64683", - "metadata": {}, - "source": [ - "## Overview\n", - "- **pairs_to_features**: converts `(aptamer_seq, protein_seq)` pairs into feature vectors using k-mer + PSeAAC.\n", - "- **FeatureSelector**: a Random Forest-based transformer that selects important features.\n", - "- **SkorchAptaNet**: a PyTorch MLP wrapped in Skorch for binary classification with a configurable threshold.\n", - "- **load_pfoa_structure**: helper to load PFOA molecule structure from PDB file." - ] - }, - { - "cell_type": "markdown", - "id": "b53a5052", - "metadata": {}, - "source": [ - "## Imports\n", - "Import the core functions and classes." - ] - }, - { - "cell_type": "code", - "execution_count": null, - "id": "15eabec8", - "metadata": {}, - "outputs": [], - "source": [ - "# General imports\n", - "import torch # noqa: I001\n", - "\n", - "# Data imports\n", - "from pyaptamer.datasets import load_1gnh_structure\n", - "from pyaptamer.utils.struct_to_aaseq import struct_to_aaseq\n", - "\n", - "# If you want to use the AptaNet pipeline, you can import it directly\n", - "from pyaptamer.aptanet import AptaNetPipeline\n", - "\n", - "# If you to build your own aptamer pipeline, you should use the following imports\n", - "from skorch import NeuralNetBinaryClassifier\n", - "from sklearn.preprocessing import FunctionTransformer\n", - "from sklearn.ensemble import RandomForestClassifier\n", - "from sklearn.feature_selection import SelectFromModel\n", - "from pyaptamer.utils._aptanet_utils import pairs_to_features\n", - "from pyaptamer.aptanet._aptanet_nn import AptaNetMLP" - ] - }, - { - "cell_type": "markdown", - "id": "45c592d9", - "metadata": {}, - "source": [ - "## Data preparation\n", - "To train the skorch network the notebook uses:\n", - "* As `X`:\n", - " * 5 random aptamer sequences of length>30 (to satisfy the default lambda value of 30 set in the PSeAAC algorithm).\n", - " * Amino-acid sequences extracted from the 1GNH protein molecule.\n", - "* As `y`:\n", - " * A random binary value (0/1) equal to the number of `(aptamer_seq, protein_seq)` pairs as dummy data." - ] - }, - { - "cell_type": "code", - "execution_count": 2, - "id": "a2f6701d", - "metadata": {}, - "outputs": [], - "source": [ - "aptamer_sequence = [\n", - " \"GGGAGGACGAAGACGACUCGAGACAGGCUAGGGAGGGA\",\n", - " \"AAGCGUCGGAUCUACACGUGCGAUAGCUCAGUACGCGGU\",\n", - " \"CGGUAUCGAGUACAGGAGUCCGACGGAUAGUCCGGAGC\",\n", - " \"UAGCUAGCGAACUAGGCGUAGCUUCGAGUAGCUACGGAA\",\n", - " \"GCUAGGACGAUCGCACGUGACCGUCAGUAGCGUAGGAGA\",\n", - "]\n", - "\n", - "gnh = load_1gnh_structure()\n", - "protein_sequence = struct_to_aaseq(gnh)\n", - "\n", - "# Build all combinations (aptamer, protein)\n", - "X = [(a, p) for a in aptamer_sequence for p in protein_sequence]\n", - "\n", - "# Dummy binary labels for the pairs\n", - "y = torch.randint(0, 2, (len(X),), dtype=torch.float32)" - ] - }, - { - "cell_type": "markdown", - "id": "cd459190", - "metadata": {}, - "source": [ - "## Build your own pipeline\n", - " To build a scikit-learn pipeline, follow these steps:\n", - "1. Convert the input to the desired (aptamer_sequence, protein_sequence) format.\n", - " * OPTIONAL: As mentioned in the paper, perform under-sampling using the \n", - " Neighborhood Cleaning Rule to balance the classes.\n", - "2. Get the PSeAAC feature vectors for your converted input (using `pairs_to_features`).\n", - "3. Select the number of features to use from the feature vector (using `FeatureSelector`).\n", - "4. Define the skorch neural network (using `AptaNetMLP`)." - ] - }, - { - "cell_type": "markdown", - "id": "c10ae4ea", - "metadata": {}, - "source": [ - "## Different workflows\n", - "In this notebook we will cover 2 different workflows one can follow, in ascending order of customizability:\n", - "\n", - "1. A minimal workflow with no dataset balancing, while using the in-built pipeline.\n", - "3. Dataset balancing using under-sampling, while using your own pipeline." - ] - }, - { - "cell_type": "markdown", - "id": "5b7c1997", - "metadata": {}, - "source": [ - "### First workflow\n", - "A minimal workflow with no dataset balancing, while using the in-built pipeline." - ] - }, - { - "cell_type": "code", - "execution_count": 3, - "id": "d782bca8", - "metadata": {}, - "outputs": [], - "source": [ - "pipeline = AptaNetPipeline()" - ] - }, - { - "cell_type": "markdown", - "id": "37db693e", - "metadata": {}, - "source": [ - "### Second workflow\n", - "Dataset balancing using under-sampling, while using your own pipeline." - ] - }, - { - "cell_type": "code", - "execution_count": null, - "id": "0cf0bed1", - "metadata": {}, - "outputs": [], - "source": [ - "# OPTIONAL: If you want to use the Neighborhood Cleaning Rule for under-sampling\n", - "# %pip install imblearn\n", - "from imblearn.under_sampling import NeighbourhoodCleaningRule # noqa: E402" - ] - }, - { - "cell_type": "code", - "execution_count": null, - "id": "13fb1669", - "metadata": {}, - "outputs": [], - "source": [ - "# NOTE: If you want to use the under-sampling, you need to install imbalanced-learn\n", - "# and use the Pipeline from imblearn\n", - "from imblearn.pipeline import Pipeline\n", - "\n", - "pipeline = AptaNetPipeline()\n", - "\n", - "feature_transformer = FunctionTransformer(\n", - " func=pairs_to_features,\n", - " validate=False,\n", - " # Optional arguments for pairs_to_features\n", - " # example: kw_args={'k': 4, 'pseaac_kwargs': {'lambda_value': 30}}\n", - " kw_args={},\n", - ")\n", - "\n", - "selector = SelectFromModel(\n", - " estimator=RandomForestClassifier(\n", - " n_estimators=300,\n", - " max_depth=9,\n", - " random_state=None,\n", - " ),\n", - " threshold=\"mean\",\n", - ")\n", - "\n", - "# Define the classifier\n", - "net = NeuralNetBinaryClassifier(\n", - " module=AptaNetMLP,\n", - " module__input_dim=None,\n", - " module__hidden_dim=128,\n", - " module__n_hidden=7,\n", - " module__dropout=0.3,\n", - " module__output_dim=1,\n", - " module__use_lazy=True,\n", - " criterion=torch.nn.BCEWithLogitsLoss,\n", - " max_epochs=200,\n", - " lr=0.00014,\n", - " optimizer=torch.optim.RMSprop,\n", - " optimizer__alpha=0.9,\n", - " optimizer__eps=1e-08,\n", - " device=\"cuda\" if torch.cuda.is_available() else \"cpu\",\n", - ")\n", - "\n", - "pipeline = Pipeline(\n", - " [\n", - " (\"features\", feature_transformer),\n", - " # Optional under-sampling, use sklearn's Pipeline if you do not need it\n", - " (\"ncr\", NeighbourhoodCleaningRule()),\n", - " (\"selector\", selector),\n", - " (\"clf\", net),\n", - " ]\n", - ")" - ] - }, - { - "cell_type": "markdown", - "id": "4d70138a", - "metadata": {}, - "source": [ - "## Model Training and Prediction\n", - "\n", - "Now that we’ve defined our AptaNet pipeline, we proceed to train the model, and use it to predict, on our aptamer-protein dataset." - ] - }, - { - "cell_type": "code", - "execution_count": 6, - "id": "1ed76399", - "metadata": {}, - "outputs": [ - { - "name": "stdout", - "output_type": "stream", - "text": [ - " epoch train_loss valid_acc valid_loss dur\n", - "------- ------------ ----------- ------------ ------\n", - " 1 \u001b[36m0.7270\u001b[0m \u001b[32m0.2857\u001b[0m \u001b[35m0.7139\u001b[0m 0.1351\n", - " 2 0.7593 0.2857 \u001b[35m0.7133\u001b[0m 0.0065\n", - " 3 \u001b[36m0.6690\u001b[0m 0.2857 \u001b[35m0.7128\u001b[0m 0.0060\n", - " 4 0.7504 0.2857 \u001b[35m0.7124\u001b[0m 0.0070\n", - " 5 0.7646 0.2857 \u001b[35m0.7121\u001b[0m 0.0065\n", - " 6 0.7945 0.2857 \u001b[35m0.7117\u001b[0m 0.0075\n", - " 7 \u001b[36m0.6541\u001b[0m 0.2857 \u001b[35m0.7114\u001b[0m 0.0052\n", - " 8 0.7842 0.2857 \u001b[35m0.7111\u001b[0m 0.0075\n", - " 9 \u001b[36m0.6305\u001b[0m 0.2857 \u001b[35m0.7107\u001b[0m 0.0065\n", - " 10 0.7223 0.2857 \u001b[35m0.7104\u001b[0m 0.0075\n", - " 11 0.6717 0.2857 \u001b[35m0.7101\u001b[0m 0.0075\n", - " 12 0.7168 0.2857 \u001b[35m0.7098\u001b[0m 0.0085\n", - " 13 0.7049 0.2857 \u001b[35m0.7095\u001b[0m 0.0084\n", - " 14 0.6947 0.2857 \u001b[35m0.7093\u001b[0m 0.0060\n", - 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" 170 0.6226 0.7143 \u001b[35m0.6616\u001b[0m 0.0070\n", - " 171 0.6712 0.7143 \u001b[35m0.6611\u001b[0m 0.0070\n", - " 172 0.5928 0.7143 \u001b[35m0.6607\u001b[0m 0.0080\n", - " 173 0.6135 0.7143 \u001b[35m0.6603\u001b[0m 0.0095\n", - " 174 0.6226 0.7143 \u001b[35m0.6598\u001b[0m 0.0095\n", - " 175 0.6370 0.7143 \u001b[35m0.6594\u001b[0m 0.0096\n", - " 176 0.6274 0.7143 \u001b[35m0.6590\u001b[0m 0.0075\n", - " 177 0.6356 0.7143 \u001b[35m0.6587\u001b[0m 0.0065\n", - " 178 0.5901 0.7143 \u001b[35m0.6582\u001b[0m 0.0075\n", - " 179 0.5951 0.7143 \u001b[35m0.6580\u001b[0m 0.0105\n", - " 180 0.6393 0.7143 \u001b[35m0.6575\u001b[0m 0.0111\n", - " 181 0.6670 0.7143 \u001b[35m0.6571\u001b[0m 0.0072\n", - " 182 0.5908 0.7143 \u001b[35m0.6567\u001b[0m 0.0085\n", - " 183 0.6036 0.7143 \u001b[35m0.6563\u001b[0m 0.0074\n", - " 184 0.6216 0.7143 \u001b[35m0.6559\u001b[0m 0.0065\n", - " 185 0.6546 0.7143 \u001b[35m0.6555\u001b[0m 0.0084\n", - " 186 0.6552 0.7143 \u001b[35m0.6551\u001b[0m 0.0065\n", - " 187 0.6021 0.7143 \u001b[35m0.6546\u001b[0m 0.0075\n", - " 188 0.6297 0.7143 \u001b[35m0.6542\u001b[0m 0.0065\n", - " 189 0.6158 0.7143 \u001b[35m0.6537\u001b[0m 0.0075\n", - " 190 0.5664 0.7143 \u001b[35m0.6532\u001b[0m 0.0060\n", - " 191 0.5799 0.7143 \u001b[35m0.6528\u001b[0m 0.0070\n", - " 192 0.6279 0.7143 \u001b[35m0.6524\u001b[0m 0.0062\n", - " 193 0.5838 0.7143 \u001b[35m0.6520\u001b[0m 0.0073\n", - " 194 0.5488 0.7143 \u001b[35m0.6516\u001b[0m 0.0055\n", - " 195 0.6394 0.7143 \u001b[35m0.6511\u001b[0m 0.0065\n", - " 196 0.6153 0.7143 \u001b[35m0.6508\u001b[0m 0.0075\n", - " 197 0.6353 0.7143 \u001b[35m0.6505\u001b[0m 0.0060\n", - " 198 0.6536 0.7143 \u001b[35m0.6500\u001b[0m 0.0063\n", - " 199 0.6070 0.7143 \u001b[35m0.6497\u001b[0m 0.0055\n", - " 200 0.5572 0.7143 \u001b[35m0.6493\u001b[0m 0.0065\n" - ] - } - ], - "source": [ - "# Fit the pipeline on the aptamer-protein pairs\n", - "pipeline.fit(X, y)\n", - "\n", - "# Predict the labels for the training data\n", - "y_pred = pipeline.predict(X)" - ] - }, - { - "cell_type": "code", - "execution_count": 7, - "id": "945dc876", - "metadata": {}, - "outputs": [ - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Training Accuracy: 0.48\n" - ] - } - ], - "source": [ - "# Optional: Evaluate training accuracy\n", - "from sklearn.metrics import accuracy_score\n", - "\n", - "print(\"Training Accuracy:\", accuracy_score(y, y_pred))" - ] - } - ], - "metadata": { - "kernelspec": { - "display_name": "pyaptamer-latest", - "language": "python", - "name": "python3" - }, - "language_info": { - "codemirror_mode": { - "name": "ipython", - "version": 3 - }, - "file_extension": ".py", - "mimetype": "text/x-python", - "name": "python", - "nbconvert_exporter": "python", - "pygments_lexer": "ipython3", - "version": "3.12.11" - } - }, - "nbformat": 4, - "nbformat_minor": 5 -} diff --git a/pyaptamer/aptanet/_feature_classifier.py b/pyaptamer/aptanet/_feature_classifier.py index 578211a1..7f8ccbe6 100644 --- a/pyaptamer/aptanet/_feature_classifier.py +++ b/pyaptamer/aptanet/_feature_classifier.py @@ -1,5 +1,5 @@ __author__ = "satvshr" -__all__ = ["AptaNetPredictor"] +__all__ = ["AptaNetClassifier"] import numpy as np import torch @@ -13,17 +13,16 @@ from torch import optim from pyaptamer.aptanet._aptanet_nn import AptaNetMLP -from pyaptamer.utils.tag_checks import task_check -class AptaNetPredictor(ClassifierMixin, BaseEstimator): +class AptaNetClassifier(ClassifierMixin, BaseEstimator): """ This estimator applies a tree-based `SelectFromModel` using a RandomForest to filter input features, then trains a skorch-wrapped multi-layer perceptron - (`AptaNetMLP`) with BCE-with-logits (default). This mirrors the AptaNet-style deep + (`AptaNetMLP`) with BCE-with-logits. This mirrors the AptaNet-style deep model used for aptamer–protein interaction prediction. - This predictor builds an internal sklearn `Pipeline` and delegates `fit`, + This classifier builds an internal sklearn `Pipeline` and delegates `fit`, `predict`, and other methods to it, while exposing convenient knobs for both the selector and the neural network. @@ -40,8 +39,6 @@ class AptaNetPredictor(ClassifierMixin, BaseEstimator): Parameters ---------- - task : str, default="classification" - Task type, either "classification" or "regression". input_dim : int or None, default=None Size of the input layer in the neural net. If `None`, it should be inferred from the feature matrix shape by the underlying module. @@ -69,11 +66,8 @@ class AptaNetPredictor(ClassifierMixin, BaseEstimator): Verbosity level for the underlying skorch `NeuralNetBinaryClassifier`. """ - _tags = {"tasks": ["classification", "regression"]} - def __init__( self, - task="classification", input_dim=None, hidden_dim=128, n_hidden=7, @@ -87,7 +81,6 @@ def __init__( threshold="mean", verbose=0, ): - self.task = task self.input_dim = input_dim self.hidden_dim = hidden_dim self.n_hidden = n_hidden @@ -100,10 +93,9 @@ def __init__( self.random_state = random_state self.threshold = threshold self.verbose = verbose - task_check(self) def _build_pipeline(self): - from skorch import NeuralNetBinaryClassifier, NeuralNetRegressor + from skorch import NeuralNetBinaryClassifier base_estimator = self.estimator or RandomForestClassifier( n_estimators=300, max_depth=9, random_state=self.random_state @@ -114,42 +106,23 @@ def _build_pipeline(self): threshold=self.threshold, ) - if self.task == "classification": - net = NeuralNetBinaryClassifier( - module=AptaNetMLP, - module__input_dim=self.input_dim, - module__hidden_dim=self.hidden_dim, - module__n_hidden=self.n_hidden, - module__dropout=self.dropout, - module__output_dim=1, - module__use_lazy=True, - criterion=nn.BCEWithLogitsLoss, - max_epochs=self.max_epochs, - lr=self.lr, - optimizer=optim.RMSprop, - optimizer__alpha=self.alpha, - optimizer__eps=self.eps, - device="cuda" if torch.cuda.is_available() else "cpu", - verbose=self.verbose, - ) - else: - net = NeuralNetRegressor( - module=AptaNetMLP, - module__input_dim=self.input_dim, - module__hidden_dim=self.hidden_dim, - module__n_hidden=self.n_hidden, - module__dropout=self.dropout, - module__output_dim=1, - module__use_lazy=True, - criterion=nn.MSELoss, - max_epochs=self.max_epochs, - lr=self.lr, - optimizer=optim.RMSprop, - optimizer__alpha=self.alpha, - optimizer__eps=self.eps, - device="cuda" if torch.cuda.is_available() else "cpu", - verbose=self.verbose, - ) + net = NeuralNetBinaryClassifier( + module=AptaNetMLP, + module__input_dim=self.input_dim, + module__hidden_dim=self.hidden_dim, + module__n_hidden=self.n_hidden, + module__dropout=self.dropout, + module__output_dim=1, + module__use_lazy=True, + criterion=nn.BCEWithLogitsLoss, + max_epochs=self.max_epochs, + lr=self.lr, + optimizer=optim.RMSprop, + optimizer__alpha=self.alpha, + optimizer__eps=self.eps, + device="cuda" if torch.cuda.is_available() else "cpu", + verbose=self.verbose, + ) return Pipeline([("select", selector), ("net", net)]) diff --git a/pyaptamer/benchmarking/_base.py b/pyaptamer/benchmarking/_base.py index 06b2a1ca..13af9af0 100644 --- a/pyaptamer/benchmarking/_base.py +++ b/pyaptamer/benchmarking/_base.py @@ -1,21 +1,67 @@ -from pyaptamer.utils.tag_checks import task_check +from sklearn.base import clone class Benchmark: - """Base class for benchmarking different estimators on various datasets.""" + """ + Train on each train dataset and evaluate on every test dataset + with each estimator & evaluator. - _tags = {"tasks": ["classification", "regression"]} + Input format: + estimators: list[estimator] + train_datasets: dict[str, pd.DataFrame] with columns ["X", "y"] + test_datasets: dict[str, pd.DataFrame] with columns ["X", "y"] + evaluators: list[callable(y_true, y_pred) -> float] + """ - def __init__(self, estimators, dataset_Loaders, evaluators, task): - self.estimators = [estimators] - self.dataset_Loaders = [dataset_Loaders] - self.evaluators = [evaluators] - self.task = task - task_check(self) + def __init__(self, estimators, train_datasets, test_datasets, evaluators): + self.estimators = estimators if isinstance(estimators, list) else [estimators] + self.train_datasets = train_datasets + self.test_datasets = test_datasets + self.evaluators = evaluators if isinstance(evaluators, list) else [evaluators] def run(self): + # Each estimator is trained on each training dataset and evaluated on all test + # datasets. + # Results are nested as: + # results[estimator_name][train_dataset_name][test_dataset_name][evaluator_name] + # = score + # Which looks like: + # { + # "EstimatorA": { + # "train_dataset_1": { + # "test_dataset_1": {"evaluator_1": result, "evaluator_2": result}, + # "test_dataset_2": {...} + # }, + # "train_dataset_2": {...} + # }, + # "EstimatorB": { + # ... + # } + # } results = {} - for _estimator in self.estimators: - for dataset_Loader in self.dataset_Loaders: - dataset_name = dataset_Loader.id - results[dataset_name] = {} + + for estimator in self.estimators: + estimator_name = estimator.__class__.__name__ + results[estimator_name] = {} + + for train_name, train_df in self.train_datasets.items(): + model = clone(estimator) + model.fit(train_df["X"], train_df["y"]) + results[estimator_name][train_name] = {} + + for test_name, test_df in self.test_datasets.items(): + y_true = test_df["y"] + y_pred = model.predict(test_df["X"]) + test_results = {} + + for evaluator in self.evaluators: + evaluator_name = getattr( + evaluator, + "__name__", + getattr(evaluator, "name", evaluator.__class__.__name__), + ) + test_results[evaluator_name] = evaluator(y_true, y_pred) + + results[estimator_name][train_name][test_name] = test_results + + return results diff --git a/pyaptamer/datasets/_loaders/_csv_loader.py b/pyaptamer/datasets/_loaders/_csv_loader.py new file mode 100644 index 00000000..2d582525 --- /dev/null +++ b/pyaptamer/datasets/_loaders/_csv_loader.py @@ -0,0 +1,37 @@ +__author__ = ["nennomp"] +__all__ = ["load_csv_dataset"] + +import os + +import pandas as pd + + +def load_csv_dataset(name: str) -> pd.DataFrame: + """Load a dataset from a CSV file. + + Parameters + ---------- + name : str + Name of the dataset to load. + + Returns + ------- + pandas.DataFrame + A DataFrame containing the dataset loaded from the CSV file. + + Raises + ------ + FileNotFoundError + If the specified CSV file does not exist. + """ + path = os.path.relpath( + os.path.join(os.path.dirname(__file__), "..", "data", f"{name}.csv") + ) + + if os.path.exists(path): + dataset = pd.read_csv(path) + return dataset + else: + raise FileNotFoundError( + f"Dataset {name} not found at {path}. Please ensure the file exists." + ) diff --git a/pyaptamer/utils/tag_checks.py b/pyaptamer/utils/tag_checks.py deleted file mode 100644 index 36eefb5a..00000000 --- a/pyaptamer/utils/tag_checks.py +++ /dev/null @@ -1,5 +0,0 @@ -def task_check(estimator): - if estimator.task not in estimator._tags["tasks"]: - raise ValueError( - f"Invalid task '{estimator.task}'. Must be a {estimator._tags['tasks']}." - ) diff --git a/x.py b/x.py index 0fdc64ca..729aa10e 100644 --- a/x.py +++ b/x.py @@ -1,4 +1,3 @@ -from pyaptamer.datasets._loaders._pfoa_loader import load_pfoa_structure +from pyaptamer.aptanet import AptaNetPipeline -a = load_pfoa_structure() -print(a.id) +print(AptaNetPipeline().__class__.__name__) From 57a113f50a725d2ce0737e63f620e801f88a5796 Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Wed, 3 Sep 2025 12:58:22 +0530 Subject: [PATCH 115/145] Added metaclass to ensre no new public methods, made some other progress too --- pyaptamer/benchmarking/_base.py | 35 +++++++++++++++++-- pyaptamer/benchmarking/preprocessors/_base.py | 22 ++++++++++++ pyaptamer/datasets/__init__.py | 2 ++ pyaptamer/utils/__init__.py | 14 ++------ pyaptamer/utils/meta_classes.py | 22 ++++++++++++ pyaptamer/utils/tag_checks.py | 8 +++++ x.py | 4 +-- 7 files changed, 92 insertions(+), 15 deletions(-) create mode 100644 pyaptamer/benchmarking/preprocessors/_base.py create mode 100644 pyaptamer/utils/meta_classes.py create mode 100644 pyaptamer/utils/tag_checks.py diff --git a/pyaptamer/benchmarking/_base.py b/pyaptamer/benchmarking/_base.py index 13af9af0..6d853a3b 100644 --- a/pyaptamer/benchmarking/_base.py +++ b/pyaptamer/benchmarking/_base.py @@ -1,5 +1,8 @@ +import pandas as pd from sklearn.base import clone +from pyaptamer.utils.tag_checks import task_check + class Benchmark: """ @@ -13,11 +16,15 @@ class Benchmark: evaluators: list[callable(y_true, y_pred) -> float] """ - def __init__(self, estimators, train_datasets, test_datasets, evaluators): + _tags = {"tasks": ["classification", "regression"]} + + def __init__(self, estimators, train_datasets, test_datasets, evaluators, task): self.estimators = estimators if isinstance(estimators, list) else [estimators] self.train_datasets = train_datasets self.test_datasets = test_datasets self.evaluators = evaluators if isinstance(evaluators, list) else [evaluators] + self.task = task + self.results = None def run(self): # Each estimator is trained on each training dataset and evaluated on all test @@ -38,6 +45,7 @@ def run(self): # ... # } # } + task_check(self) results = {} for estimator in self.estimators: @@ -64,4 +72,27 @@ def run(self): results[estimator_name][train_name][test_name] = test_results - return results + self.results = self._to_df(results) + + return self.results + + def _to_df(self, results): + """Convert nested dict results → dict of DataFrames and print neatly.""" + dfs = {} + for estimator, train_dict in results.items(): + train_df = [] + for train_set, test_dict in train_dict.items(): + df = pd.DataFrame(test_dict) # metrics × test_sets + df["train_set"] = train_set + df = df.set_index(["train_set"], append=True) + df = df.reorder_levels(["train_set", df.index.names[0]]) + train_df.append(df) + + dfs[estimator] = pd.concat(train_df) + + # Print nicely + for est, df in dfs.items(): + print(f"\n=== {est} ===") + print(df) + + return dfs diff --git a/pyaptamer/benchmarking/preprocessors/_base.py b/pyaptamer/benchmarking/preprocessors/_base.py new file mode 100644 index 00000000..d9000a1f --- /dev/null +++ b/pyaptamer/benchmarking/preprocessors/_base.py @@ -0,0 +1,22 @@ +import pandas as pd + +from pyaptamer.utils.meta_classes import NoNewPublicMethods + + +class BasePreprocessor(metaclass=NoNewPublicMethods): + """Base class for all preprocessors.""" + + def _ensure_format(self, df): + """Ensure input is in the correct df format.""" + if not isinstance(df, pd.DataFrame): + df = pd.DataFrame(df) + required_columns = {"X", "y"} + missing = required_columns - set(df.columns) + if missing: + raise ValueError(f"Input DataFrame is missing columns: {missing}") + return df + + def transform(self, df): + """ """ + df = self._ensure_format(df) + return df diff --git a/pyaptamer/datasets/__init__.py b/pyaptamer/datasets/__init__.py index 41b5fa67..a1bab951 100644 --- a/pyaptamer/datasets/__init__.py +++ b/pyaptamer/datasets/__init__.py @@ -1,5 +1,6 @@ """Contains datasets along with their loaders.""" +from pyaptamer.datasets._loaders._csv_loader import load_csv_dataset from pyaptamer.datasets._loaders._one_gnh import load_1gnh_structure from pyaptamer.datasets._loaders._online_databank import load_from_rcsb from pyaptamer.datasets._loaders._pfoa_loader import load_pfoa_structure @@ -8,4 +9,5 @@ "load_pfoa_structure", "load_1gnh_structure", "load_from_rcsb", + "load_csv_dataset", ] diff --git a/pyaptamer/utils/__init__.py b/pyaptamer/utils/__init__.py index fbd6939a..d3f688bb 100644 --- a/pyaptamer/utils/__init__.py +++ b/pyaptamer/utils/__init__.py @@ -1,19 +1,11 @@ -"""Utils for the pyaptamer package.""" +"""Public utils for the pyaptamer package.""" __all__ = [ - "dna2rna", - "encode_rna", - "generate_all_aptamer_triplets", - "rna2vec", "pdb_to_struct", "struct_to_aaseq", + "task_check", ] -from pyaptamer.utils._rna import ( - dna2rna, - encode_rna, - generate_all_aptamer_triplets, - rna2vec, -) from pyaptamer.utils.pdb_to_struct import pdb_to_struct from pyaptamer.utils.struct_to_aaseq import struct_to_aaseq +from pyaptamer.utils.tag_checks import task_check diff --git a/pyaptamer/utils/meta_classes.py b/pyaptamer/utils/meta_classes.py new file mode 100644 index 00000000..b482ea26 --- /dev/null +++ b/pyaptamer/utils/meta_classes.py @@ -0,0 +1,22 @@ +class NoNewPublicMethods(type): + """A metaclass that prevents the addition of new public methods in subclasses. + Use using `metaclass=NoNewPublicMethods` in your class definition.""" + + def __init__(cls, name, bases, namespace): + # Collect all public methods already defined in base classes + allowed = set() + for base in bases: + for attr_name, attr_val in base.__dict__.items(): + if callable(attr_val) and not attr_name.startswith("_"): + allowed.add(attr_name) + + # Check new class namespace for new public methods + for attr_name, attr_val in namespace.items(): + if callable(attr_val) and not attr_name.startswith("_"): + if attr_name not in allowed: + raise TypeError( + "Class {name} is not allowed to define new" + f"public method '{attr_name}'" + ) + + super().__init__(name, bases, namespace) diff --git a/pyaptamer/utils/tag_checks.py b/pyaptamer/utils/tag_checks.py new file mode 100644 index 00000000..40d631ac --- /dev/null +++ b/pyaptamer/utils/tag_checks.py @@ -0,0 +1,8 @@ +"""Add all `_tag` checking functions here.""" + + +def task_check(estimator): + if estimator.task not in estimator._tags["tasks"]: + raise ValueError( + f"Invalid task '{estimator.task}'. Must be a {estimator._tags['tasks']}." + ) diff --git a/x.py b/x.py index 729aa10e..50896eed 100644 --- a/x.py +++ b/x.py @@ -1,3 +1,3 @@ -from pyaptamer.aptanet import AptaNetPipeline +from pyaptamer.datasets import load_csv_dataset -print(AptaNetPipeline().__class__.__name__) +print(load_csv_dataset("train_li2014")) From 1f400b06351edb9143ee47759d120f3976e52bdc Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Thu, 4 Sep 2025 02:23:26 +0530 Subject: [PATCH 116/145] Progress on Preprocessors, AptaNetPreprocessor seems completed --- pyaptamer/aptatrans/pipeline.py | 2 +- .../benchmarking/preprocessors/__init__.py | 5 ++++ pyaptamer/benchmarking/preprocessors/_base.py | 19 ++++++++---- .../benchmarking/preprocessors/aptanet.py | 10 +++++++ .../benchmarking/preprocessors/aptatrans.py | 6 ++++ pyaptamer/utils/_aptanet_utils.py | 29 +++++++++++++++++++ pyaptamer/utils/meta_classes.py | 20 +++++++++---- 7 files changed, 78 insertions(+), 13 deletions(-) create mode 100644 pyaptamer/benchmarking/preprocessors/__init__.py create mode 100644 pyaptamer/benchmarking/preprocessors/aptanet.py create mode 100644 pyaptamer/benchmarking/preprocessors/aptatrans.py diff --git a/pyaptamer/aptatrans/pipeline.py b/pyaptamer/aptatrans/pipeline.py index 11c64409..d86eafd5 100644 --- a/pyaptamer/aptatrans/pipeline.py +++ b/pyaptamer/aptatrans/pipeline.py @@ -13,7 +13,7 @@ from pyaptamer.aptatrans import AptaTrans from pyaptamer.experiments import Aptamer from pyaptamer.mcts import MCTS -from pyaptamer.utils import ( +from pyaptamer.utils._rna import ( generate_all_aptamer_triplets, ) diff --git a/pyaptamer/benchmarking/preprocessors/__init__.py b/pyaptamer/benchmarking/preprocessors/__init__.py new file mode 100644 index 00000000..88633968 --- /dev/null +++ b/pyaptamer/benchmarking/preprocessors/__init__.py @@ -0,0 +1,5 @@ +"""Preprocessing for the benchmarking module.""" + +from pyaptamer.benchmarking.preprocessors._base import BasePreprocessor + +__all__ = ["BasePreprocessor"] diff --git a/pyaptamer/benchmarking/preprocessors/_base.py b/pyaptamer/benchmarking/preprocessors/_base.py index d9000a1f..f0d5b099 100644 --- a/pyaptamer/benchmarking/preprocessors/_base.py +++ b/pyaptamer/benchmarking/preprocessors/_base.py @@ -6,17 +6,24 @@ class BasePreprocessor(metaclass=NoNewPublicMethods): """Base class for all preprocessors.""" - def _ensure_format(self, df): + def _ensure_format(self, df, required_cols=None): """Ensure input is in the correct df format.""" if not isinstance(df, pd.DataFrame): df = pd.DataFrame(df) - required_columns = {"X", "y"} - missing = required_columns - set(df.columns) + missing = required_cols - set(df.columns) if missing: - raise ValueError(f"Input DataFrame is missing columns: {missing}") - return df + raise ValueError(f"DataFrame is missing columns: {missing}") def transform(self, df): """ """ - df = self._ensure_format(df) + df = self._ensure_format(df, required_cols=["aptamer", "protein", "y"]) + + df = self._transform(df) + + df = self._ensure_format(df, required_cols=["X", "y"]) + return df + + def _transform(self, df): + """Subclasses must override this with preprocessing logic.""" + raise NotImplementedError("Subclasses must implement `_transform`.") diff --git a/pyaptamer/benchmarking/preprocessors/aptanet.py b/pyaptamer/benchmarking/preprocessors/aptanet.py new file mode 100644 index 00000000..b5e8cfa1 --- /dev/null +++ b/pyaptamer/benchmarking/preprocessors/aptanet.py @@ -0,0 +1,10 @@ +from pyaptamer.benchmarking.preprocessors import BasePreprocessor +from pyaptamer.utils._aptanet_utils import rna2dna + + +class AptaNetPreprocessor(BasePreprocessor): + def _transform(self, df): + df = df.copy() + df["aptamer"] = df["aptamer"].apply(rna2dna) + df["X"] = list(zip(df["aptamer"], df["protein"], strict=False)) + return df[["X", "y"]] diff --git a/pyaptamer/benchmarking/preprocessors/aptatrans.py b/pyaptamer/benchmarking/preprocessors/aptatrans.py new file mode 100644 index 00000000..761bab7c --- /dev/null +++ b/pyaptamer/benchmarking/preprocessors/aptatrans.py @@ -0,0 +1,6 @@ +from pyaptamer.benchmarking.preprocessors import BasePreprocessor + + +class AptaTransPreprocessor(BasePreprocessor): + def _transform(self, df): + df = df.copy() diff --git a/pyaptamer/utils/_aptanet_utils.py b/pyaptamer/utils/_aptanet_utils.py index 6cad920d..fc3fbe7d 100644 --- a/pyaptamer/utils/_aptanet_utils.py +++ b/pyaptamer/utils/_aptanet_utils.py @@ -91,3 +91,32 @@ def pairs_to_features(X, k=4): # Ensure float32 for PyTorch compatibility return np.vstack(feats).astype(np.float32) + + +def rna2dna(sequence: str) -> str: + """ + Convert an RNA sequence to a DNA sequence. + + Nucleotides 'U' in the RNA sequence are replaced with 'T' in the DNA sequence. + Unknown nucleotides are replaced with 'N'. Other nucleotides ('A', 'C', 'G') + remain unchanged. + + Parameters + ---------- + sequence : str + The RNA sequence to be converted. + + Returns + ------- + str + The converted DNA sequence. + """ + # Replace nucleotides 'U' with 'T' + result = sequence.translate(str.maketrans("U", "T")) + + # Replace any unknown characters with 'N' + for char in result: + if char not in "ACGT": + result = result.replace(char, "N") + + return result diff --git a/pyaptamer/utils/meta_classes.py b/pyaptamer/utils/meta_classes.py index b482ea26..a0fb2d80 100644 --- a/pyaptamer/utils/meta_classes.py +++ b/pyaptamer/utils/meta_classes.py @@ -1,22 +1,30 @@ class NoNewPublicMethods(type): - """A metaclass that prevents the addition of new public methods in subclasses. - Use using `metaclass=NoNewPublicMethods` in your class definition.""" + """A metaclass that prevents subclasses from: + 1. Adding new public methods. + 2. Overriding existing public methods. + Use using `metaclass=NoNewPublicMethods` in your class definition. + """ def __init__(cls, name, bases, namespace): # Collect all public methods already defined in base classes - allowed = set() + allowed = {} for base in bases: for attr_name, attr_val in base.__dict__.items(): if callable(attr_val) and not attr_name.startswith("_"): - allowed.add(attr_name) + allowed[attr_name] = attr_val - # Check new class namespace for new public methods + # Check new class namespace for public methods for attr_name, attr_val in namespace.items(): if callable(attr_val) and not attr_name.startswith("_"): if attr_name not in allowed: raise TypeError( - "Class {name} is not allowed to define new" + f"Class {name} is not allowed to define new " f"public method '{attr_name}'" ) + elif attr_val is not allowed[attr_name]: + raise TypeError( + f"Class {name} is not allowed to override " + f"existing public method '{attr_name}'" + ) super().__init__(name, bases, namespace) From 8b466672021bceb076a8a7910ffb9c10c947b7af Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Thu, 4 Sep 2025 20:45:30 +0530 Subject: [PATCH 117/145] Continued improving on benchmarking and preprocessing --- pyaptamer/benchmarking/__init__.py | 4 + pyaptamer/benchmarking/_base.py | 233 ++++++++++++++---- pyaptamer/benchmarking/preprocessors/_base.py | 86 ++++++- x.ipynb | 16 ++ x.py | 3 - 5 files changed, 278 insertions(+), 64 deletions(-) create mode 100644 x.ipynb delete mode 100644 x.py diff --git a/pyaptamer/benchmarking/__init__.py b/pyaptamer/benchmarking/__init__.py index 403026e7..0066312f 100644 --- a/pyaptamer/benchmarking/__init__.py +++ b/pyaptamer/benchmarking/__init__.py @@ -1 +1,5 @@ """Benchmarking module.""" + +from pyaptamer.benchmarking._base import Benchmarking + +__all__ = ["Benchmarking"] diff --git a/pyaptamer/benchmarking/_base.py b/pyaptamer/benchmarking/_base.py index 6d853a3b..a20a2ae9 100644 --- a/pyaptamer/benchmarking/_base.py +++ b/pyaptamer/benchmarking/_base.py @@ -1,50 +1,207 @@ import pandas as pd from sklearn.base import clone +from sklearn.model_selection import train_test_split from pyaptamer.utils.tag_checks import task_check -class Benchmark: +class Benchmarking: """ Train on each train dataset and evaluate on every test dataset with each estimator & evaluator. - Input format: - estimators: list[estimator] - train_datasets: dict[str, pd.DataFrame] with columns ["X", "y"] - test_datasets: dict[str, pd.DataFrame] with columns ["X", "y"] - evaluators: list[callable(y_true, y_pred) -> float] + You can either: + (A) pass `datasets` (raw frames with columns ["aptamer","protein","y"]) + and let this class preprocess + split for you; or + (B) pass `train_datasets` and `test_datasets` + which may be EITHER raw (["aptamer","protein","y"]) OR preprocessed + (["X","y"]). + + Parameters + ---------- + estimators : list[estimator] | estimator + evaluators : list[callable] | callable + task : str + "classification" or "regression". + preprocessor : BasePreprocessor | None + Used to convert raw ["aptamer","protein","y"] -> ["X","y"] when needed. + datasets : dict[str, pd.DataFrame] | None + Raw datasets to be split into train/test (if provided). + train_datasets : dict[str, pd.DataFrame] | None + Training datasets (raw or preprocessed). + test_datasets : dict[str, pd.DataFrame] | None + Test datasets (raw or preprocessed). + test_size : float + Fraction for the test split when using `datasets`. + stratify : bool + If True and task=="classification", use y for stratification + (only when splitting). + random_state : int | None + Random state for reproducibility in splits. """ _tags = {"tasks": ["classification", "regression"]} - def __init__(self, estimators, train_datasets, test_datasets, evaluators, task): + def __init__( + self, + estimators, + evaluators, + task, + *, + preprocessor=None, + datasets=None, + train_datasets=None, + test_datasets=None, + test_size=0.2, + stratify=True, + random_state=42, + ): self.estimators = estimators if isinstance(estimators, list) else [estimators] - self.train_datasets = train_datasets - self.test_datasets = test_datasets self.evaluators = evaluators if isinstance(evaluators, list) else [evaluators] self.task = task + self.preprocessor = preprocessor + self.test_size = float(test_size) + self.stratify_flag = bool(stratify) + self.random_state = random_state + + # accept either (datasets) or (train/test) + # normalize datasets to dict + self._raw_datasets = self._normalize_to_dict(datasets, prefix="dataset") + self._train_datasets_in = self._normalize_to_dict( + train_datasets, prefix="train" + ) + self._test_datasets_in = self._normalize_to_dict(test_datasets, prefix="test") + + # prepared containers + self.train_datasets = {} + self.test_datasets = {} + self.results = None + # prepare datasets immediately + self._prepare_datasets() + + def _normalize_to_dict(self, data, prefix): + if data is None: + return None + if isinstance(data, pd.DataFrame): + return {f"{prefix}_0": data} + if isinstance(data, list): + return {f"{prefix}_{i}": df for i, df in enumerate(data)} + if isinstance(data, dict): + return data + raise ValueError(f"Unsupported dataset type: {type(data)}") + + def _maybe_preprocess(self, df): + """ + Ensure df has only ["X","y"]. + - If extra columns are present, warn and return only ["X","y"]. + - If missing, run the preprocessor and reduce to ["X","y"]. + """ + import warnings + + if {"X", "y"}.issubset(df.columns): + if set(df.columns) != {"X", "y"}: + warnings.warn( + f"Extra columns {set(df.columns) - {'X', 'y'}} found. " + "Only ['X','y'] will be kept.", + stacklevel=2, + ) + return df[["X", "y"]] + + if self.preprocessor is None: + raise ValueError( + "Input DataFrame does not have ['X','y'] and no preprocessor" + "was provided." + ) + + df_proc = self.preprocessor.transform(df) + return df_proc[["X", "y"]] + + def _split_one(self, name, df): + """ + Split a single dataset into train/test and return preprocessed splits. + Works whether `df` is raw or already preprocessed. + Returns (train_df, test_df, train_name, test_name). + """ + df_proc = self._maybe_preprocess(df) + X, y = df_proc["X"], df_proc["y"] + + stratify_vec = ( + y if (self.task == "classification" and self.stratify_flag) else None + ) + + X_train, X_test, y_train, y_test = train_test_split( + X, + y, + test_size=self.test_size, + random_state=self.random_state, + stratify=stratify_vec, + ) + + train_df = pd.DataFrame({"X": X_train, "y": y_train}).reset_index() + test_df = pd.DataFrame({"X": X_test, "y": y_test}).reset_index() + + train_name = f"{name}__train" + test_name = f"{name}__test" + return train_df, test_df, train_name, test_name + + def _prepare_datasets(self): + """ + Build self.train_datasets and self.test_datasets from provided inputs. + """ + # case A: user provided raw datasets to split + if self._raw_datasets is not None: + for name, df in self._raw_datasets.items(): + train, test, train_name, test_name = self._split_one(name, df) + self.train_datasets[train_name] = train + self.test_datasets[test_name] = test + + # case B: user provided train/test datasets (each may be raw or preprocessed) + if self._train_datasets_in is not None: + for name, df in self._train_datasets_in.items(): + self.train_datasets[name] = self._maybe_preprocess(df) + + if self._test_datasets_in is not None: + for name, df in self._test_datasets_in.items(): + self.test_datasets[name] = self._maybe_preprocess(df) + + if not self.train_datasets or not self.test_datasets: + raise ValueError( + "No datasets prepared. Provide either `datasets` to split or " + "`train_datasets` and `test_datasets` (raw or with ['X','y'])." + ) + + def _to_df(self, results): + """Convert nested dict results → dict of DataFrames and print neatly.""" + dfs = {} + for estimator, train_dict in results.items(): + train_df_blocks = [] + for train_set, test_dict in train_dict.items(): + df = pd.DataFrame(test_dict) # metrics × test_sets + df["train_set"] = train_set + df = df.set_index(["train_set"], append=True) + df = df.reorder_levels(["train_set", df.index.names[0]]) + train_df_blocks.append(df) + + dfs[estimator] = pd.concat(train_df_blocks) + + for est, df in dfs.items(): + print(f"\n=== {est} ===") + print(df) + + return dfs + def run(self): - # Each estimator is trained on each training dataset and evaluated on all test - # datasets. - # Results are nested as: - # results[estimator_name][train_dataset_name][test_dataset_name][evaluator_name] - # = score - # Which looks like: - # { - # "EstimatorA": { - # "train_dataset_1": { - # "test_dataset_1": {"evaluator_1": result, "evaluator_2": result}, - # "test_dataset_2": {...} - # }, - # "train_dataset_2": {...} - # }, - # "EstimatorB": { - # ... - # } - # } + """ + Train each estimator on each training dataset and evaluate on all test datasets. + + Returns + ------- + dict[str, pd.DataFrame] + Mapping estimator_name -> DataFrame of metrics + (rows = train_set, cols = test_sets). + """ task_check(self) results = {} @@ -73,26 +230,4 @@ def run(self): results[estimator_name][train_name][test_name] = test_results self.results = self._to_df(results) - return self.results - - def _to_df(self, results): - """Convert nested dict results → dict of DataFrames and print neatly.""" - dfs = {} - for estimator, train_dict in results.items(): - train_df = [] - for train_set, test_dict in train_dict.items(): - df = pd.DataFrame(test_dict) # metrics × test_sets - df["train_set"] = train_set - df = df.set_index(["train_set"], append=True) - df = df.reorder_levels(["train_set", df.index.names[0]]) - train_df.append(df) - - dfs[estimator] = pd.concat(train_df) - - # Print nicely - for est, df in dfs.items(): - print(f"\n=== {est} ===") - print(df) - - return dfs diff --git a/pyaptamer/benchmarking/preprocessors/_base.py b/pyaptamer/benchmarking/preprocessors/_base.py index f0d5b099..ff2e53c7 100644 --- a/pyaptamer/benchmarking/preprocessors/_base.py +++ b/pyaptamer/benchmarking/preprocessors/_base.py @@ -4,26 +4,88 @@ class BasePreprocessor(metaclass=NoNewPublicMethods): - """Base class for all preprocessors.""" + """ + Base class for all preprocessors. - def _ensure_format(self, df, required_cols=None): - """Ensure input is in the correct df format.""" + A preprocessor takes a pandas DataFrame with columns "aptamer", "protein", + and "y", and converts it into a DataFrame with columns "X" (features) + and "y" (target). + + The exact conversion logic depends on the algorithm being processed. + """ + + def _ensure_format(self, df, required_cols, only_required_cols=False): + """ + Ensure input is a DataFrame with the required columns. + + Parameters + ---------- + df : pandas.DataFrame or dict-like + Input data. + required_cols : iterable of str + Column names that must be present. + only_required_cols : bool, default=False + If True, return a DataFrame with only the required columns. + + Returns + ------- + df : pandas.DataFrame + Validated DataFrame. + + Raises + ------ + ValueError + If required columns are missing. + """ if not isinstance(df, pd.DataFrame): df = pd.DataFrame(df) - missing = required_cols - set(df.columns) - if missing: - raise ValueError(f"DataFrame is missing columns: {missing}") - def transform(self, df): - """ """ - df = self._ensure_format(df, required_cols=["aptamer", "protein", "y"]) + if required_cols is not None: + missing = set(required_cols) - set(df.columns) + if missing: + raise ValueError(f"DataFrame is missing columns: {missing}") - df = self._transform(df) + if only_required_cols and required_cols is not None: + return df[required_cols] - df = self._ensure_format(df, required_cols=["X", "y"]) + return df + + def transform(self, df, only_required_cols=True): + """ + Transform input DataFrame into feature/target representation. + + Parameters + ---------- + df : pandas.DataFrame + Must contain "aptamer", "protein", and "y" columns. + only_required_cols_cols : bool, default=True + If True, return only the required columns ["X","y"] at the end. + + Returns + ------- + df : pandas.DataFrame + Must contain "X" (features) and "y" (target) columns. + """ + df = self._ensure_format(df, required_cols=["aptamer", "protein", "y"]) + df = self._transform(df) + df = self._ensure_format( + df, required_cols=["X", "y"], only_required_cols=only_required_cols + ) return df def _transform(self, df): - """Subclasses must override this with preprocessing logic.""" + """ + Apply subclass-specific preprocessing. + + Parameters + ---------- + df : pandas.DataFrame + Input DataFrame with "aptamer", "protein", "y". + + Returns + ------- + df : pandas.DataFrame + Transformed DataFrame with "X" and "y". + """ raise NotImplementedError("Subclasses must implement `_transform`.") diff --git a/x.ipynb b/x.ipynb new file mode 100644 index 00000000..c2c1872a --- /dev/null +++ b/x.ipynb @@ -0,0 +1,16 @@ +{ + "cells": [], + "metadata": { + "kernelspec": { + "display_name": "pyaptamer-latest", + "language": "python", + "name": "python3" + }, + "language_info": { + "name": "python", + "version": "3.12.11" + } + }, + "nbformat": 4, + "nbformat_minor": 5 +} diff --git a/x.py b/x.py deleted file mode 100644 index 50896eed..00000000 --- a/x.py +++ /dev/null @@ -1,3 +0,0 @@ -from pyaptamer.datasets import load_csv_dataset - -print(load_csv_dataset("train_li2014")) From b91eaadfc3d91232057f8761e4233ed819a4d01c Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Thu, 4 Sep 2025 21:33:08 +0530 Subject: [PATCH 118/145] bug fixing and improvements --- pyaptamer/benchmarking/_base.py | 84 +++++--- pyaptamer/utils/meta_classes.py | 11 +- pyaptamer/utils/tests/test_rna.py | 7 +- x.ipynb | 329 +++++++++++++++++++++++++++++- 4 files changed, 396 insertions(+), 35 deletions(-) diff --git a/pyaptamer/benchmarking/_base.py b/pyaptamer/benchmarking/_base.py index a20a2ae9..1e2b2541 100644 --- a/pyaptamer/benchmarking/_base.py +++ b/pyaptamer/benchmarking/_base.py @@ -79,11 +79,38 @@ def __init__( self.results = None # prepare datasets immediately - self._prepare_datasets() + self._build_datasets() + + def _build_datasets(self): + """ + Build self.train_datasets and self.test_datasets from provided inputs. + """ + # case A: user provided raw datasets to split + if self._raw_datasets is not None: + for name, df in self._raw_datasets.items(): + train, test, train_name, test_name = self._split_dataset(name, df) + self.train_datasets[train_name] = train + self.test_datasets[test_name] = test + + # case B: user provided train/test datasets (each may be raw or preprocessed) + if self._train_datasets_in is not None: + for name, df in self._train_datasets_in.items(): + self.train_datasets[name] = self._ensure_preprocessed(df) + + if self._test_datasets_in is not None: + for name, df in self._test_datasets_in.items(): + self.test_datasets[name] = self._ensure_preprocessed(df) + + if not self.train_datasets or not self.test_datasets: + raise ValueError( + "No datasets prepared. Provide either `datasets` to split or " + "`train_datasets` and `test_datasets` (raw or with ['X','y'])." + ) + + for name, df in {**self.train_datasets, **self.test_datasets}.items(): + self._validate_xy(df, name=name) def _normalize_to_dict(self, data, prefix): - if data is None: - return None if isinstance(data, pd.DataFrame): return {f"{prefix}_0": data} if isinstance(data, list): @@ -92,7 +119,7 @@ def _normalize_to_dict(self, data, prefix): return data raise ValueError(f"Unsupported dataset type: {type(data)}") - def _maybe_preprocess(self, df): + def _ensure_preprocessed(self, df): """ Ensure df has only ["X","y"]. - If extra columns are present, warn and return only ["X","y"]. @@ -118,13 +145,13 @@ def _maybe_preprocess(self, df): df_proc = self.preprocessor.transform(df) return df_proc[["X", "y"]] - def _split_one(self, name, df): + def _split_dataset(self, name, df): """ Split a single dataset into train/test and return preprocessed splits. Works whether `df` is raw or already preprocessed. Returns (train_df, test_df, train_name, test_name). """ - df_proc = self._maybe_preprocess(df) + df_proc = self._ensure_preprocessed(df) X, y = df_proc["X"], df_proc["y"] stratify_vec = ( @@ -146,31 +173,28 @@ def _split_one(self, name, df): test_name = f"{name}__test" return train_df, test_df, train_name, test_name - def _prepare_datasets(self): - """ - Build self.train_datasets and self.test_datasets from provided inputs. - """ - # case A: user provided raw datasets to split - if self._raw_datasets is not None: - for name, df in self._raw_datasets.items(): - train, test, train_name, test_name = self._split_one(name, df) - self.train_datasets[train_name] = train - self.test_datasets[test_name] = test - - # case B: user provided train/test datasets (each may be raw or preprocessed) - if self._train_datasets_in is not None: - for name, df in self._train_datasets_in.items(): - self.train_datasets[name] = self._maybe_preprocess(df) - - if self._test_datasets_in is not None: - for name, df in self._test_datasets_in.items(): - self.test_datasets[name] = self._maybe_preprocess(df) + def _validate_xy(self, df, name="dataset"): + if not {"X", "y"}.issubset(df.columns): + raise ValueError(f"{name} is missing required columns ['X','y'].") + + if len(df["X"]) != len(df["y"]): + raise ValueError(f"{name} has mismatched X/y lengths.") + + if self.task == "classification": + # y should be discrete + if pd.api.types.is_numeric_dtype( + df["y"] + ) and not pd.api.types.is_integer_dtype(df["y"]): + raise ValueError( + f"{name}: classification target y must be categorical/integer, not" + "float." + ) + elif self.task == "regression": + # y should be numeric + if not pd.api.types.is_numeric_dtype(df["y"]): + raise ValueError(f"{name}: regression target y must be numeric.") - if not self.train_datasets or not self.test_datasets: - raise ValueError( - "No datasets prepared. Provide either `datasets` to split or " - "`train_datasets` and `test_datasets` (raw or with ['X','y'])." - ) + return df[["X", "y"]] def _to_df(self, results): """Convert nested dict results → dict of DataFrames and print neatly.""" diff --git a/pyaptamer/utils/meta_classes.py b/pyaptamer/utils/meta_classes.py index a0fb2d80..7f865152 100644 --- a/pyaptamer/utils/meta_classes.py +++ b/pyaptamer/utils/meta_classes.py @@ -2,18 +2,23 @@ class NoNewPublicMethods(type): """A metaclass that prevents subclasses from: 1. Adding new public methods. 2. Overriding existing public methods. - Use using `metaclass=NoNewPublicMethods` in your class definition. + Use with `metaclass=NoNewPublicMethods`. """ def __init__(cls, name, bases, namespace): - # Collect all public methods already defined in base classes + # if the only base is object, allow free definition (root class) + if all(base is object for base in bases): + super().__init__(name, bases, namespace) + return + + # collect all allowed public methods from bases allowed = {} for base in bases: for attr_name, attr_val in base.__dict__.items(): if callable(attr_val) and not attr_name.startswith("_"): allowed[attr_name] = attr_val - # Check new class namespace for public methods + # check the new class namespace for attr_name, attr_val in namespace.items(): if callable(attr_val) and not attr_name.startswith("_"): if attr_name not in allowed: diff --git a/pyaptamer/utils/tests/test_rna.py b/pyaptamer/utils/tests/test_rna.py index 62a33735..b671f297 100644 --- a/pyaptamer/utils/tests/test_rna.py +++ b/pyaptamer/utils/tests/test_rna.py @@ -8,7 +8,12 @@ import pytest import torch -from pyaptamer.utils import dna2rna, encode_rna, generate_all_aptamer_triplets, rna2vec +from pyaptamer.utils._rna import ( + dna2rna, + encode_rna, + generate_all_aptamer_triplets, + rna2vec, +) @pytest.mark.parametrize( diff --git a/x.ipynb b/x.ipynb index c2c1872a..94cd8464 100644 --- a/x.ipynb +++ b/x.ipynb @@ -1,5 +1,324 @@ { - "cells": [], + "cells": [ + { + "cell_type": "code", + "execution_count": 1, + "id": "44825503", + "metadata": {}, + "outputs": [], + "source": [ + "from pyaptamer.benchmarking import Benchmarking\n", + "from pyaptamer.benchmarking.preprocessors.aptanet import AptaNetPreprocessor\n", + "from pyaptamer.datasets import load_csv_dataset" + ] + }, + { + "cell_type": "code", + "execution_count": 2, + "id": "af9807c2", + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + " aptamer \\\n", + "0 UCGGAGGUGGUUCAGCUCUGCAUCGACAGUUGGC \n", + "1 CGGGGTGTTGTCCTGTGCTCTCCGGAGAGCACAGGACAACACCCCG \n", + "2 GCTGCAGTTGCACTGAATTCGCCTCTCGCCTCCGTACACTTAGTCG... \n", + "3 TATTTGCCCTTGCAGGCCGCAGGAGTGCTAGCAGT \n", + "4 UCUCUGGGCUCUUAGGAGAACGGAUAGGAGUGUGCUCGCU \n", + "... ... \n", + "2315 CGAUACAGCACUGAUUGCGGUCGAGGUAGCUUGAUGGGCC \n", + "2316 GATGTGGGTGTAGTTGGAGGGTAAACGTT \n", + "2317 ACATGTGATGATATATCGTGTCTCGTGATA \n", + "2318 GGGAGAGGAGGGAGAUAGAUAUCAAGAUAAAAACGCCGGCGUAGCG... \n", + "2319 CTTCTGCCCGCCTCCTTCCAGAGTAGCCAAGCGGAGAGTATTTTTG... \n", + "\n", + " protein label \n", + "0 MDSTNYISKLFEYAQRQGQISDIKFEEVGTDGPDHLKTFTLRVVIK... positive \n", + "1 MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSI... positive \n", + "2 MDEVGAQVAAPMFIHQSLGRKRDLYYPMSNRLVQSQPQRRDEWNSK... positive \n", + "3 PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGK... positive \n", + "4 LQENFLPQPRQQHHGTLVLHYRPHREEAGMQHPCLWPGSSHCSDDS... positive \n", + "... ... ... \n", + "2315 MANLGYWLLALFVTMWTDVGLCKKRPKPGGWNTGGSRYPGQGSPGG... negative \n", + "2316 MVKSHIGSWILVLFVAMWSDVGLCKKRPKPGGGWNTGGSRYPGQGS... negative \n", + "2317 MKKRKVLIPLMALSTILVSSTGNLEVIQAEVKQENRLLNESESSSQ... negative \n", + "2318 MASNFTQFVLVDNGGTGDVTVAPSNFANGVAEWISSNSRSQAYKVT... negative \n", + "2319 MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRTVM... negative \n", + "\n", + "[2320 rows x 3 columns]\n" + ] + } + ], + "source": [ + "print(load_csv_dataset(\"train_li2014\"))" + ] + }, + { + "cell_type": "code", + "execution_count": 4, + "id": "f41a9480", + "metadata": {}, + "outputs": [], + "source": [ + "# --- imports\n", + "from sklearn.metrics import accuracy_score, f1_score\n", + "\n", + "# AptaNetPipeline import (cover common locations)\n", + "from pyaptamer.aptanet import AptaNetPipeline\n", + "from pyaptamer.datasets import load_csv_dataset\n", + "\n", + "# --- load raw dataset (aptamer/protein/y)\n", + "df = load_csv_dataset(\"train_li2014\")\n", + "\n", + "# --- preprocessor\n", + "pre = AptaNetPreprocessor()\n", + "\n", + "# --- AptaNet model/pipeline (use defaults; tweak if you like)\n", + "clf = AptaNetPipeline()" + ] + }, + { + "cell_type": "code", + "execution_count": 5, + "id": "644f0222", + "metadata": {}, + "outputs": [ + { + "data": { + "text/html": [ + "
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aptamerproteinlabel
0UCGGAGGUGGUUCAGCUCUGCAUCGACAGUUGGCMDSTNYISKLFEYAQRQGQISDIKFEEVGTDGPDHLKTFTLRVVIK...positive
1CGGGGTGTTGTCCTGTGCTCTCCGGAGAGCACAGGACAACACCCCGMDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSI...positive
2GCTGCAGTTGCACTGAATTCGCCTCTCGCCTCCGTACACTTAGTCG...MDEVGAQVAAPMFIHQSLGRKRDLYYPMSNRLVQSQPQRRDEWNSK...positive
3TATTTGCCCTTGCAGGCCGCAGGAGTGCTAGCAGTPISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGK...positive
4UCUCUGGGCUCUUAGGAGAACGGAUAGGAGUGUGCUCGCULQENFLPQPRQQHHGTLVLHYRPHREEAGMQHPCLWPGSSHCSDDS...positive
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aptamerproteiny
0UCGGAGGUGGUUCAGCUCUGCAUCGACAGUUGGCMDSTNYISKLFEYAQRQGQISDIKFEEVGTDGPDHLKTFTLRVVIK...1
1CGGGGTGTTGTCCTGTGCTCTCCGGAGAGCACAGGACAACACCCCGMDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSI...1
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3TATTTGCCCTTGCAGGCCGCAGGAGTGCTAGCAGTPISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGK...1
4UCUCUGGGCUCUUAGGAGAACGGAUAGGAGUGUGCUCGCULQENFLPQPRQQHHGTLVLHYRPHREEAGMQHPCLWPGSSHCSDDS...1
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" + ], + "text/plain": [ + " aptamer \\\n", + "0 UCGGAGGUGGUUCAGCUCUGCAUCGACAGUUGGC \n", + "1 CGGGGTGTTGTCCTGTGCTCTCCGGAGAGCACAGGACAACACCCCG \n", + "2 GCTGCAGTTGCACTGAATTCGCCTCTCGCCTCCGTACACTTAGTCG... \n", + "3 TATTTGCCCTTGCAGGCCGCAGGAGTGCTAGCAGT \n", + "4 UCUCUGGGCUCUUAGGAGAACGGAUAGGAGUGUGCUCGCU \n", + "\n", + " protein y \n", + "0 MDSTNYISKLFEYAQRQGQISDIKFEEVGTDGPDHLKTFTLRVVIK... 1 \n", + "1 MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSI... 1 \n", + "2 MDEVGAQVAAPMFIHQSLGRKRDLYYPMSNRLVQSQPQRRDEWNSK... 1 \n", + "3 PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGK... 1 \n", + "4 LQENFLPQPRQQHHGTLVLHYRPHREEAGMQHPCLWPGSSHCSDDS... 1 " + ] + }, + "execution_count": 6, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "df = df.rename(columns={\"label\": \"y\"})\n", + "\n", + "# 2. Map values\n", + "df[\"y\"] = df[\"y\"].map({\"negative\": 0, \"positive\": 1})\n", + "\n", + "df.head()" + ] + }, + { + "cell_type": "code", + "execution_count": 7, + "id": "6169daa2", + "metadata": {}, + "outputs": [ + { + "ename": "TypeError", + "evalue": "Cannot clone object '' (type ): it does not seem to be a scikit-learn estimator as it does not implement a 'get_params' method.", + "output_type": "error", + "traceback": [ + "\u001b[31m---------------------------------------------------------------------------\u001b[39m", + "\u001b[31mTypeError\u001b[39m Traceback (most recent call last)", + "\u001b[36mCell\u001b[39m\u001b[36m \u001b[39m\u001b[32mIn[7]\u001b[39m\u001b[32m, line 14\u001b[39m\n\u001b[32m 2\u001b[39m bench = Benchmarking(\n\u001b[32m 3\u001b[39m estimators=[clf],\n\u001b[32m 4\u001b[39m evaluators=[accuracy_score, f1_score],\n\u001b[32m (...)\u001b[39m\u001b[32m 10\u001b[39m random_state=\u001b[32m1337\u001b[39m,\n\u001b[32m 11\u001b[39m )\n\u001b[32m 13\u001b[39m \u001b[38;5;66;03m# --- run\u001b[39;00m\n\u001b[32m---> \u001b[39m\u001b[32m14\u001b[39m results = \u001b[43mbench\u001b[49m\u001b[43m.\u001b[49m\u001b[43mrun\u001b[49m\u001b[43m(\u001b[49m\u001b[43m)\u001b[49m\n\u001b[32m 16\u001b[39m \u001b[38;5;66;03m# results is: { \"AptaNetPipeline\": }\u001b[39;00m\n\u001b[32m 17\u001b[39m results\n", + "\u001b[36mFile \u001b[39m\u001b[32mc:\\Users\\satvm\\pyaptamer\\pyaptamer\\benchmarking\\_base.py:213\u001b[39m, in \u001b[36mrun\u001b[39m\u001b[34m(self)\u001b[39m\n\u001b[32m 209\u001b[39m train_df_blocks.append(df)\n\u001b[32m 211\u001b[39m dfs[estimator] = pd.concat(train_df_blocks)\n\u001b[32m--> \u001b[39m\u001b[32m213\u001b[39m \u001b[38;5;28;01mfor\u001b[39;00m est, df \u001b[38;5;129;01min\u001b[39;00m dfs.items():\n\u001b[32m 214\u001b[39m \u001b[38;5;28mprint\u001b[39m(\u001b[33mf\u001b[39m\u001b[33m\"\u001b[39m\u001b[38;5;130;01m\\n\u001b[39;00m\u001b[33m=== \u001b[39m\u001b[38;5;132;01m{\u001b[39;00mest\u001b[38;5;132;01m}\u001b[39;00m\u001b[33m ===\u001b[39m\u001b[33m\"\u001b[39m)\n\u001b[32m 215\u001b[39m \u001b[38;5;28mprint\u001b[39m(df)\n", + "\u001b[36mFile \u001b[39m\u001b[32mc:\\Users\\satvm\\miniconda3\\envs\\pyaptamer-latest\\Lib\\site-packages\\sklearn\\base.py:95\u001b[39m, in \u001b[36mclone\u001b[39m\u001b[34m(estimator, safe)\u001b[39m\n\u001b[32m 93\u001b[39m \u001b[38;5;28;01mif\u001b[39;00m \u001b[38;5;28mhasattr\u001b[39m(estimator, \u001b[33m\"\u001b[39m\u001b[33m__sklearn_clone__\u001b[39m\u001b[33m\"\u001b[39m) \u001b[38;5;129;01mand\u001b[39;00m \u001b[38;5;129;01mnot\u001b[39;00m inspect.isclass(estimator):\n\u001b[32m 94\u001b[39m \u001b[38;5;28;01mreturn\u001b[39;00m estimator.__sklearn_clone__()\n\u001b[32m---> \u001b[39m\u001b[32m95\u001b[39m \u001b[38;5;28;01mreturn\u001b[39;00m \u001b[43m_clone_parametrized\u001b[49m\u001b[43m(\u001b[49m\u001b[43mestimator\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43msafe\u001b[49m\u001b[43m=\u001b[49m\u001b[43msafe\u001b[49m\u001b[43m)\u001b[49m\n", + "\u001b[36mFile \u001b[39m\u001b[32mc:\\Users\\satvm\\miniconda3\\envs\\pyaptamer-latest\\Lib\\site-packages\\sklearn\\base.py:117\u001b[39m, in \u001b[36m_clone_parametrized\u001b[39m\u001b[34m(estimator, safe)\u001b[39m\n\u001b[32m 111\u001b[39m \u001b[38;5;28;01mraise\u001b[39;00m \u001b[38;5;167;01mTypeError\u001b[39;00m(\n\u001b[32m 112\u001b[39m \u001b[33m\"\u001b[39m\u001b[33mCannot clone object. \u001b[39m\u001b[33m\"\u001b[39m\n\u001b[32m 113\u001b[39m \u001b[33m\"\u001b[39m\u001b[33mYou should provide an instance of \u001b[39m\u001b[33m\"\u001b[39m\n\u001b[32m 114\u001b[39m \u001b[33m\"\u001b[39m\u001b[33mscikit-learn estimator instead of a class.\u001b[39m\u001b[33m\"\u001b[39m\n\u001b[32m 115\u001b[39m )\n\u001b[32m 116\u001b[39m \u001b[38;5;28;01melse\u001b[39;00m:\n\u001b[32m--> \u001b[39m\u001b[32m117\u001b[39m \u001b[38;5;28;01mraise\u001b[39;00m \u001b[38;5;167;01mTypeError\u001b[39;00m(\n\u001b[32m 118\u001b[39m \u001b[33m\"\u001b[39m\u001b[33mCannot clone object \u001b[39m\u001b[33m'\u001b[39m\u001b[38;5;132;01m%s\u001b[39;00m\u001b[33m'\u001b[39m\u001b[33m (type \u001b[39m\u001b[38;5;132;01m%s\u001b[39;00m\u001b[33m): \u001b[39m\u001b[33m\"\u001b[39m\n\u001b[32m 119\u001b[39m \u001b[33m\"\u001b[39m\u001b[33mit does not seem to be a scikit-learn \u001b[39m\u001b[33m\"\u001b[39m\n\u001b[32m 120\u001b[39m \u001b[33m\"\u001b[39m\u001b[33mestimator as it does not implement a \u001b[39m\u001b[33m\"\u001b[39m\n\u001b[32m 121\u001b[39m \u001b[33m\"\u001b[39m\u001b[33m'\u001b[39m\u001b[33mget_params\u001b[39m\u001b[33m'\u001b[39m\u001b[33m method.\u001b[39m\u001b[33m\"\u001b[39m % (\u001b[38;5;28mrepr\u001b[39m(estimator), \u001b[38;5;28mtype\u001b[39m(estimator))\n\u001b[32m 122\u001b[39m )\n\u001b[32m 124\u001b[39m klass = estimator.\u001b[34m__class__\u001b[39m\n\u001b[32m 125\u001b[39m new_object_params = estimator.get_params(deep=\u001b[38;5;28;01mFalse\u001b[39;00m)\n", + "\u001b[31mTypeError\u001b[39m: Cannot clone object '' (type ): it does not seem to be a scikit-learn estimator as it does not implement a 'get_params' method." + ] + } + ], + "source": [ + "# --- set up the benchmark (auto split + stratify)\n", + "bench = Benchmarking(\n", + " estimators=[clf],\n", + " evaluators=[accuracy_score, f1_score],\n", + " task=\"classification\",\n", + " preprocessor=pre,\n", + " datasets=df, # can also be [df1, df2] or {\"my_ds\": df}\n", + " test_size=0.25,\n", + " stratify=True,\n", + " random_state=1337,\n", + ")\n", + "\n", + "# --- run\n", + "results = bench.run()\n", + "\n", + "# results is: { \"AptaNetPipeline\": }\n", + "results" + ] + }, + { + "cell_type": "code", + "execution_count": null, + "id": "146556ba", + "metadata": {}, + "outputs": [], + "source": [] + } + ], "metadata": { "kernelspec": { "display_name": "pyaptamer-latest", @@ -7,7 +326,15 @@ "name": "python3" }, "language_info": { + "codemirror_mode": { + "name": "ipython", + "version": 3 + }, + "file_extension": ".py", + "mimetype": "text/x-python", "name": "python", + "nbconvert_exporter": "python", + "pygments_lexer": "ipython3", "version": "3.12.11" } }, From 5e3f4d6749a4837a9e2720ee0cc77ce8799c3101 Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Fri, 5 Sep 2025 03:12:14 +0530 Subject: [PATCH 119/145] seems to be working, very slow though --- pyaptamer/benchmarking/_base.py | 7 ++-- pyaptamer/pseaac/_features.py | 9 ++--- pyaptamer/utils/_pseaac_utils.py | 35 ++++++++++++++----- x.ipynb | 60 ++++++++++++++++++++------------ x.py | 36 +++++++++++++++++++ 5 files changed, 109 insertions(+), 38 deletions(-) create mode 100644 x.py diff --git a/pyaptamer/benchmarking/_base.py b/pyaptamer/benchmarking/_base.py index 1e2b2541..ba89e0e8 100644 --- a/pyaptamer/benchmarking/_base.py +++ b/pyaptamer/benchmarking/_base.py @@ -1,5 +1,4 @@ import pandas as pd -from sklearn.base import clone from sklearn.model_selection import train_test_split from pyaptamer.utils.tag_checks import task_check @@ -111,6 +110,8 @@ def _build_datasets(self): self._validate_xy(df, name=name) def _normalize_to_dict(self, data, prefix): + if data is None: + return None if isinstance(data, pd.DataFrame): return {f"{prefix}_0": data} if isinstance(data, list): @@ -226,6 +227,8 @@ def run(self): Mapping estimator_name -> DataFrame of metrics (rows = train_set, cols = test_sets). """ + import copy + task_check(self) results = {} @@ -234,7 +237,7 @@ def run(self): results[estimator_name] = {} for train_name, train_df in self.train_datasets.items(): - model = clone(estimator) + model = copy.deepcopy(estimator) model.fit(train_df["X"], train_df["y"]) results[estimator_name][train_name] = {} diff --git a/pyaptamer/pseaac/_features.py b/pyaptamer/pseaac/_features.py index 4e1c9644..bcd24e31 100644 --- a/pyaptamer/pseaac/_features.py +++ b/pyaptamer/pseaac/_features.py @@ -6,7 +6,7 @@ import numpy as np from pyaptamer.pseaac._props import aa_props -from pyaptamer.utils._pseaac_utils import AMINO_ACIDS, is_valid_aa +from pyaptamer.utils._pseaac_utils import AMINO_ACIDS, clean_protein_seq class PSeAAC: @@ -225,11 +225,8 @@ def transform(self, protein_sequence): f"Protein sequence is too short, should be longer than `lambda_val`. " f"Sequence length: {seq_len}, `lambda_val`: {self.lambda_val}." ) - if not is_valid_aa(protein_sequence): - raise ValueError( - "Invalid amino acid found in protein_sequence. " - f"Only {''.join(AMINO_ACIDS)} are allowed." - ) + + protein_sequence = clean_protein_seq(protein_sequence) all_pseaac = [] for prop_group in self.prop_groups: diff --git a/pyaptamer/utils/_pseaac_utils.py b/pyaptamer/utils/_pseaac_utils.py index 02911dc7..7635d0d0 100644 --- a/pyaptamer/utils/_pseaac_utils.py +++ b/pyaptamer/utils/_pseaac_utils.py @@ -7,17 +7,16 @@ Functions --------- -is_valid_aa(seq) - Returns True if all characters in the input string are valid amino acid - codes, False otherwise. +clean_protein_seq(seq) + Replaces invalid amino acids with "N" and warn the user. """ AMINO_ACIDS = list("ACDEFGHIKLMNPQRSTVWY") -def is_valid_aa(seq): +def clean_protein_seq(seq): """ - Check if the sequence contains only valid amino acids. + Replace invalid amino acids with "N" and warn the user. Parameters ---------- @@ -26,7 +25,27 @@ def is_valid_aa(seq): Returns ------- - bool - True if all characters are valid amino acids, False otherwise. + str + Cleaned protein sequence where all invalid characters have been replaced + with "N". """ - return all(aa in AMINO_ACIDS for aa in seq) + import warnings + + cleaned = [] + invalid_found = False + + for aa in seq: + if aa in AMINO_ACIDS: + cleaned.append(aa) + else: + cleaned.append("N") + invalid_found = True + + if invalid_found: + warnings.warn( + "Invalid amino acid(s) found in sequence. Replaced with 'N'.", + UserWarning, + stacklevel=2, + ) + + return "".join(cleaned) diff --git a/x.ipynb b/x.ipynb index 94cd8464..48d68b5d 100644 --- a/x.ipynb +++ b/x.ipynb @@ -58,7 +58,7 @@ }, { "cell_type": "code", - "execution_count": 4, + "execution_count": 3, "id": "f41a9480", "metadata": {}, "outputs": [], @@ -82,7 +82,7 @@ }, { "cell_type": "code", - "execution_count": 5, + "execution_count": 4, "id": "644f0222", "metadata": {}, "outputs": [ @@ -163,7 +163,7 @@ "4 LQENFLPQPRQQHHGTLVLHYRPHREEAGMQHPCLWPGSSHCSDDS... positive " ] }, - "execution_count": 5, + "execution_count": 4, "metadata": {}, "output_type": "execute_result" } @@ -174,7 +174,7 @@ }, { "cell_type": "code", - "execution_count": 6, + "execution_count": 5, "id": "b9eb8099", "metadata": {}, "outputs": [ @@ -255,7 +255,7 @@ "4 LQENFLPQPRQQHHGTLVLHYRPHREEAGMQHPCLWPGSSHCSDDS... 1 " ] }, - "execution_count": 6, + "execution_count": 5, "metadata": {}, "output_type": "execute_result" } @@ -271,23 +271,42 @@ }, { "cell_type": "code", - "execution_count": 7, + "execution_count": null, "id": "6169daa2", "metadata": {}, "outputs": [ { - "ename": "TypeError", - "evalue": "Cannot clone object '' (type ): it does not seem to be a scikit-learn estimator as it does not implement a 'get_params' method.", - "output_type": "error", - "traceback": [ - "\u001b[31m---------------------------------------------------------------------------\u001b[39m", - "\u001b[31mTypeError\u001b[39m Traceback (most recent call last)", - "\u001b[36mCell\u001b[39m\u001b[36m \u001b[39m\u001b[32mIn[7]\u001b[39m\u001b[32m, line 14\u001b[39m\n\u001b[32m 2\u001b[39m bench = Benchmarking(\n\u001b[32m 3\u001b[39m estimators=[clf],\n\u001b[32m 4\u001b[39m evaluators=[accuracy_score, f1_score],\n\u001b[32m (...)\u001b[39m\u001b[32m 10\u001b[39m random_state=\u001b[32m1337\u001b[39m,\n\u001b[32m 11\u001b[39m )\n\u001b[32m 13\u001b[39m \u001b[38;5;66;03m# --- run\u001b[39;00m\n\u001b[32m---> \u001b[39m\u001b[32m14\u001b[39m results = \u001b[43mbench\u001b[49m\u001b[43m.\u001b[49m\u001b[43mrun\u001b[49m\u001b[43m(\u001b[49m\u001b[43m)\u001b[49m\n\u001b[32m 16\u001b[39m \u001b[38;5;66;03m# results is: { \"AptaNetPipeline\": }\u001b[39;00m\n\u001b[32m 17\u001b[39m results\n", - "\u001b[36mFile \u001b[39m\u001b[32mc:\\Users\\satvm\\pyaptamer\\pyaptamer\\benchmarking\\_base.py:213\u001b[39m, in \u001b[36mrun\u001b[39m\u001b[34m(self)\u001b[39m\n\u001b[32m 209\u001b[39m train_df_blocks.append(df)\n\u001b[32m 211\u001b[39m dfs[estimator] = pd.concat(train_df_blocks)\n\u001b[32m--> \u001b[39m\u001b[32m213\u001b[39m \u001b[38;5;28;01mfor\u001b[39;00m est, df \u001b[38;5;129;01min\u001b[39;00m dfs.items():\n\u001b[32m 214\u001b[39m \u001b[38;5;28mprint\u001b[39m(\u001b[33mf\u001b[39m\u001b[33m\"\u001b[39m\u001b[38;5;130;01m\\n\u001b[39;00m\u001b[33m=== \u001b[39m\u001b[38;5;132;01m{\u001b[39;00mest\u001b[38;5;132;01m}\u001b[39;00m\u001b[33m ===\u001b[39m\u001b[33m\"\u001b[39m)\n\u001b[32m 215\u001b[39m \u001b[38;5;28mprint\u001b[39m(df)\n", - "\u001b[36mFile \u001b[39m\u001b[32mc:\\Users\\satvm\\miniconda3\\envs\\pyaptamer-latest\\Lib\\site-packages\\sklearn\\base.py:95\u001b[39m, in \u001b[36mclone\u001b[39m\u001b[34m(estimator, safe)\u001b[39m\n\u001b[32m 93\u001b[39m \u001b[38;5;28;01mif\u001b[39;00m \u001b[38;5;28mhasattr\u001b[39m(estimator, \u001b[33m\"\u001b[39m\u001b[33m__sklearn_clone__\u001b[39m\u001b[33m\"\u001b[39m) \u001b[38;5;129;01mand\u001b[39;00m \u001b[38;5;129;01mnot\u001b[39;00m inspect.isclass(estimator):\n\u001b[32m 94\u001b[39m \u001b[38;5;28;01mreturn\u001b[39;00m estimator.__sklearn_clone__()\n\u001b[32m---> \u001b[39m\u001b[32m95\u001b[39m \u001b[38;5;28;01mreturn\u001b[39;00m \u001b[43m_clone_parametrized\u001b[49m\u001b[43m(\u001b[49m\u001b[43mestimator\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43msafe\u001b[49m\u001b[43m=\u001b[49m\u001b[43msafe\u001b[49m\u001b[43m)\u001b[49m\n", - "\u001b[36mFile \u001b[39m\u001b[32mc:\\Users\\satvm\\miniconda3\\envs\\pyaptamer-latest\\Lib\\site-packages\\sklearn\\base.py:117\u001b[39m, in \u001b[36m_clone_parametrized\u001b[39m\u001b[34m(estimator, safe)\u001b[39m\n\u001b[32m 111\u001b[39m \u001b[38;5;28;01mraise\u001b[39;00m \u001b[38;5;167;01mTypeError\u001b[39;00m(\n\u001b[32m 112\u001b[39m \u001b[33m\"\u001b[39m\u001b[33mCannot clone object. \u001b[39m\u001b[33m\"\u001b[39m\n\u001b[32m 113\u001b[39m \u001b[33m\"\u001b[39m\u001b[33mYou should provide an instance of \u001b[39m\u001b[33m\"\u001b[39m\n\u001b[32m 114\u001b[39m \u001b[33m\"\u001b[39m\u001b[33mscikit-learn estimator instead of a class.\u001b[39m\u001b[33m\"\u001b[39m\n\u001b[32m 115\u001b[39m )\n\u001b[32m 116\u001b[39m \u001b[38;5;28;01melse\u001b[39;00m:\n\u001b[32m--> \u001b[39m\u001b[32m117\u001b[39m \u001b[38;5;28;01mraise\u001b[39;00m \u001b[38;5;167;01mTypeError\u001b[39;00m(\n\u001b[32m 118\u001b[39m \u001b[33m\"\u001b[39m\u001b[33mCannot clone object \u001b[39m\u001b[33m'\u001b[39m\u001b[38;5;132;01m%s\u001b[39;00m\u001b[33m'\u001b[39m\u001b[33m (type \u001b[39m\u001b[38;5;132;01m%s\u001b[39;00m\u001b[33m): \u001b[39m\u001b[33m\"\u001b[39m\n\u001b[32m 119\u001b[39m \u001b[33m\"\u001b[39m\u001b[33mit does not seem to be a scikit-learn \u001b[39m\u001b[33m\"\u001b[39m\n\u001b[32m 120\u001b[39m \u001b[33m\"\u001b[39m\u001b[33mestimator as it does not implement a \u001b[39m\u001b[33m\"\u001b[39m\n\u001b[32m 121\u001b[39m \u001b[33m\"\u001b[39m\u001b[33m'\u001b[39m\u001b[33mget_params\u001b[39m\u001b[33m'\u001b[39m\u001b[33m method.\u001b[39m\u001b[33m\"\u001b[39m % (\u001b[38;5;28mrepr\u001b[39m(estimator), \u001b[38;5;28mtype\u001b[39m(estimator))\n\u001b[32m 122\u001b[39m )\n\u001b[32m 124\u001b[39m klass = estimator.\u001b[34m__class__\u001b[39m\n\u001b[32m 125\u001b[39m new_object_params = estimator.get_params(deep=\u001b[38;5;28;01mFalse\u001b[39;00m)\n", - "\u001b[31mTypeError\u001b[39m: Cannot clone object '' (type ): it does not seem to be a scikit-learn estimator as it does not implement a 'get_params' method." + "name": "stderr", + "output_type": "stream", + "text": [ + "c:\\Users\\satvm\\pyaptamer\\pyaptamer\\pseaac\\_features.py:229: UserWarning: Invalid amino acid(s) found in sequence. Replaced with 'N'.\n", + " protein_sequence = clean_protein_seq(protein_sequence)\n" ] + }, + { + "name": "stdout", + "output_type": "stream", + "text": [ + "\n", + "=== AptaNetPipeline ===\n", + " dataset_0__test\n", + "train_set \n", + "dataset_0__train accuracy_score 1.0\n", + " f1_score 1.0\n" + ] + }, + { + "data": { + "text/plain": [ + "{'AptaNetPipeline': dataset_0__test\n", + " train_set \n", + " dataset_0__train accuracy_score 1.0\n", + " f1_score 1.0}" + ] + }, + "execution_count": 6, + "metadata": {}, + "output_type": "execute_result" } ], "source": [ @@ -297,17 +316,14 @@ " evaluators=[accuracy_score, f1_score],\n", " task=\"classification\",\n", " preprocessor=pre,\n", - " datasets=df, # can also be [df1, df2] or {\"my_ds\": df}\n", + " datasets=df[:10], # can also be [df1, df2] or {\"my_ds\": df}\n", " test_size=0.25,\n", " stratify=True,\n", " random_state=1337,\n", ")\n", "\n", "# --- run\n", - "results = bench.run()\n", - "\n", - "# results is: { \"AptaNetPipeline\": }\n", - "results" + "results = bench.run()" ] }, { diff --git a/x.py b/x.py new file mode 100644 index 00000000..e1ad6e0f --- /dev/null +++ b/x.py @@ -0,0 +1,36 @@ +# --- imports +from sklearn.metrics import accuracy_score, f1_score + +# AptaNetPipeline import (cover common locations) +from pyaptamer.aptanet import AptaNetPipeline +from pyaptamer.benchmarking import Benchmarking +from pyaptamer.benchmarking.preprocessors.aptanet import AptaNetPreprocessor +from pyaptamer.datasets import load_csv_dataset + +# --- load raw dataset (aptamer/protein/y) +df = load_csv_dataset("train_li2014") + +# --- preprocessor +pre = AptaNetPreprocessor() + +# --- AptaNet model/pipeline (use defaults; tweak if you like) +clf = AptaNetPipeline() +df = df.rename(columns={"label": "y"}) + +# 2. Map values +df["y"] = df["y"].map({"negative": 0, "positive": 1}) + +# --- set up the benchmark (auto split + stratify) +bench = Benchmarking( + estimators=[clf], + evaluators=[accuracy_score, f1_score], + task="classification", + preprocessor=pre, + datasets=df, # can also be [df1, df2] or {"my_ds": df} + test_size=0.25, + stratify=True, + random_state=1337, +) + +# --- run +results = bench.run() From 0e79b7f4cc5c770d81aa3cdf6b84df18793110f2 Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Sat, 6 Sep 2025 11:25:16 +0530 Subject: [PATCH 120/145] Update _aptanet_utils.py --- pyaptamer/utils/_aptanet_utils.py | 6 +++--- 1 file changed, 3 insertions(+), 3 deletions(-) diff --git a/pyaptamer/utils/_aptanet_utils.py b/pyaptamer/utils/_aptanet_utils.py index fc3fbe7d..b5aaffef 100644 --- a/pyaptamer/utils/_aptanet_utils.py +++ b/pyaptamer/utils/_aptanet_utils.py @@ -93,7 +93,7 @@ def pairs_to_features(X, k=4): return np.vstack(feats).astype(np.float32) -def rna2dna(sequence: str) -> str: +def rna2dna(seq): """ Convert an RNA sequence to a DNA sequence. @@ -103,7 +103,7 @@ def rna2dna(sequence: str) -> str: Parameters ---------- - sequence : str + seq : str The RNA sequence to be converted. Returns @@ -112,7 +112,7 @@ def rna2dna(sequence: str) -> str: The converted DNA sequence. """ # Replace nucleotides 'U' with 'T' - result = sequence.translate(str.maketrans("U", "T")) + result = seq.translate(str.maketrans("U", "T")) # Replace any unknown characters with 'N' for char in result: From 8d875e292cad8765feba45b957556dbe4a293904 Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Tue, 9 Sep 2025 18:54:30 +0530 Subject: [PATCH 121/145] reset main --- pyaptamer/utils/__init__.py | 19 ++++ pyaptamer/utils/_rna.py | 202 ++++++++++++++++++++++++++++++++++++ 2 files changed, 221 insertions(+) create mode 100644 pyaptamer/utils/__init__.py create mode 100644 pyaptamer/utils/_rna.py diff --git a/pyaptamer/utils/__init__.py b/pyaptamer/utils/__init__.py new file mode 100644 index 00000000..fbd6939a --- /dev/null +++ b/pyaptamer/utils/__init__.py @@ -0,0 +1,19 @@ +"""Utils for the pyaptamer package.""" + +__all__ = [ + "dna2rna", + "encode_rna", + "generate_all_aptamer_triplets", + "rna2vec", + "pdb_to_struct", + "struct_to_aaseq", +] + +from pyaptamer.utils._rna import ( + dna2rna, + encode_rna, + generate_all_aptamer_triplets, + rna2vec, +) +from pyaptamer.utils.pdb_to_struct import pdb_to_struct +from pyaptamer.utils.struct_to_aaseq import struct_to_aaseq diff --git a/pyaptamer/utils/_rna.py b/pyaptamer/utils/_rna.py new file mode 100644 index 00000000..5756ffcb --- /dev/null +++ b/pyaptamer/utils/_rna.py @@ -0,0 +1,202 @@ +__author__ = ["nennomp"] +__all__ = [ + "dna2rna", + "encode_rna", + "generate_all_aptamer_triplets", + "rna2vec", +] + +from itertools import product + +import numpy as np +import torch +from torch import Tensor + + +def dna2rna(sequence: str) -> str: + """ + Convert a DNA sequence to an RNA sequence. + + Nucleotides 'T' in the DNA sequence are replaced with 'U' in the RNA sequence. + Unknown nucleotides are replaced with 'N'. Other nucleotides ('A', 'C', 'G') remain + unchanged. + + Parameters + ---------- + seq : str + The DNA sequence to be converted. + + Returns + ------- + str + The converted RNA sequence. + """ + # replace nucleotides 'T' with 'U' + result = sequence.translate(str.maketrans("T", "U")) + for char in result: + if char not in "ACGU": + result = result.replace(char, "N") # replace unknown nucleotides with 'N' + return result + + +def generate_all_aptamer_triplets() -> dict[str, int]: + """ + Generate a dictionary mapping all possible 3-mer RNA subsequences (triplets) to + unique indices. + + Returns + ------- + dict[str, int] + A dictionary where keys are 3-mer RNA subsequences and values are unique + indices. + """ + nucleotides = ["A", "C", "G", "U", "N"] # 'N' marks unknown nucleotides + # create a dictionary mapping every possible 3-nucleotide combination (triplet) to + # a unique index, Should be 5^3 = 125 possible triplets (AAA, AAC, AAG, ..., NNN). + words = { + "".join(triplet): i + 1 + for i, triplet in enumerate(product(nucleotides, repeat=3)) + } + return words + + +def rna2vec(sequence_list: list[str], max_sequence_length: int = 275) -> np.ndarray: + """Convert a list of RNA sequences into a numerical representation. + + First, if not already in RNA format, the sequences are converted from DNA to RNA. + Then, all overlapping triplets (3-nucleotide combinations) are extracted from each + RNA sequence and mapped to unique indices. Finally, the sequences are zero padded + to length `max_sequence_length`. The result is a numpy array where each row + corresponds to a sequence, and each column corresponds to an integer representing + the triplet's index in dictionary `words`. + + If the number of extracted triplets is grerater than `max_sequence_length`, the + sequence is truncated to fit. + + Parameters + ---------- + sequence_list : list[str] + A list containing RNA sequences as strings. + max_sequence_length : int, optional, default=275 + The maximum length of the output sequences. + + Returns + ------- + np.ndarray + A numpy array containing the numerical representation of the RNA sequences, of + shape (1, `max_sequence_length`). + + Raises + ------ + ValueError + If `max_sequence_length` is less than or equal to 0. + + Examples + -------- + >>> from pyaptamer.utils import rna2vec + >>> # two triplets: 'AAAC' -> ['AAA', 'AAC'] + >>> rna = rna2vec(["AAAC"], max_sequence_length=4) + >>> print(rna) + [[1 2 0 0]] + """ + if max_sequence_length <= 0: + raise ValueError("`max_sequence_length` must be greater than 0.") + + words = generate_all_aptamer_triplets() + + result = [] + for sequence in sequence_list: + sequence = dna2rna(sequence) + + # extract all overlapping triplets from the sequence + # e.g., 'ACGUA' -> ['ACG', 'CGU', 'GUA'] + converted = [ + words.get(sequence[i : i + 3], 0) for i in range(len(sequence) - 2) + ] + + # skip sequences that convert to an empty list + if any(converted): + padded_sequence = np.pad( + array=converted, + pad_width=(0, max_sequence_length - len(converted)), + constant_values=0, + ) + result.append(padded_sequence) + + return np.array(result) + + +def encode_rna( + sequences: list[str], + words: dict[str, int], + max_len: int, + word_max_len: int = 3, +) -> Tensor: + """Encode RNA sequences into their numerical representations. + + This function tokenizes protein sequences using a greedy longest-match approach, + where longer amino acid patterns are preferred over shorter ones. Sequences are + either trunacted or zero-padded to `max_len` tokens. + + Parameters + ---------- + sequences : list[str] + List of RNA sequences to be encoded. + words : dict[str, int] + A dictionary mappings RNA 3-mers to unique indices. + max_len : int + Maximum length of each encoded sequence. Sequences will be truncated + or padded to this length. + word_max_len : int, optional, default=3 + Maximum length of amino acid patterns to consider during tokenization. + + Returns + ------- + Tensor + Encoded sequences with shape (n_sequences, `max_len`). + + Examples + -------- + >>> from pyaptamer.utils import encode_rna + >>> words = {"A": 1, "C": 2, "D": 3, "AC": 4} + >>> print(encode_rna("ACD", words, max_len=5)) + tensor([[4, 3, 0, 0, 0]]) + """ + # handle single protein input + if isinstance(sequences, str): + sequences = [sequences] + + encoded_sequences = [] + for seq in sequences: + tokens = [] + i = 0 + + while i < len(seq): + # try to match the longest possible pattern first + matched = False + for pattern_len in range(min(word_max_len, len(seq) - i), 0, -1): + pattern = seq[i : i + pattern_len] + if pattern in words: + tokens.append(words[pattern]) + i += pattern_len + matched = True + break + + # if no pattern matched, use unknown token (0) and advance by 1 + if not matched: + tokens.append(0) + i += 1 + + # stop if we've reached max_len tokens + if len(tokens) >= max_len: + tokens = tokens[:max_len] + break + + # pad sequence to max_len + padded_tokens = tokens + [0] * (max_len - len(tokens)) + encoded_sequences.append(padded_tokens) + + # convert to numpy array first + result = np.array(encoded_sequences, dtype=np.int64) + + return torch.tensor(result, dtype=torch.int64) From effb1115902fc34d963af5616a363f52cbcb3b2e Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Tue, 9 Sep 2025 18:58:33 +0530 Subject: [PATCH 122/145] reset pt2 --- pyaptamer/aptatrans/pipeline.py | 2 +- pyaptamer/utils/tests/test_rna.py | 7 +------ 2 files changed, 2 insertions(+), 7 deletions(-) diff --git a/pyaptamer/aptatrans/pipeline.py b/pyaptamer/aptatrans/pipeline.py index d86eafd5..11c64409 100644 --- a/pyaptamer/aptatrans/pipeline.py +++ b/pyaptamer/aptatrans/pipeline.py @@ -13,7 +13,7 @@ from pyaptamer.aptatrans import AptaTrans from pyaptamer.experiments import Aptamer from pyaptamer.mcts import MCTS -from pyaptamer.utils._rna import ( +from pyaptamer.utils import ( generate_all_aptamer_triplets, ) diff --git a/pyaptamer/utils/tests/test_rna.py b/pyaptamer/utils/tests/test_rna.py index b671f297..62a33735 100644 --- a/pyaptamer/utils/tests/test_rna.py +++ b/pyaptamer/utils/tests/test_rna.py @@ -8,12 +8,7 @@ import pytest import torch -from pyaptamer.utils._rna import ( - dna2rna, - encode_rna, - generate_all_aptamer_triplets, - rna2vec, -) +from pyaptamer.utils import dna2rna, encode_rna, generate_all_aptamer_triplets, rna2vec @pytest.mark.parametrize( From 2dcc61fffd7b8e51d921163027afc7587094c930 Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Wed, 10 Sep 2025 02:56:00 +0530 Subject: [PATCH 123/145] AptaNet bug fix --- pyaptamer/aptanet/_pipeline.py | 4 ++-- 1 file changed, 2 insertions(+), 2 deletions(-) diff --git a/pyaptamer/aptanet/_pipeline.py b/pyaptamer/aptanet/_pipeline.py index 4395e23f..f73dcba3 100644 --- a/pyaptamer/aptanet/_pipeline.py +++ b/pyaptamer/aptanet/_pipeline.py @@ -61,14 +61,14 @@ class AptaNetPipeline: >>> preds = pipe.predict(X_test_pairs) """ - def __init__(self, k=None, classifier=None): + def __init__(self, k=4, classifier=None): self.k = k self.classifier = classifier def _build_pipeline(self): transformer = FunctionTransformer( func=pairs_to_features, - kw_args=self.k, + kw_args={"k": self.k}, validate=False, ) self._classifier = self.classifier or AptaNetClassifier() From 15029ad7506b75fa3adf64c8fa5c61d33592bd36 Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Wed, 10 Sep 2025 03:15:36 +0530 Subject: [PATCH 124/145] Update test_aptanet.py --- pyaptamer/aptanet/tests/test_aptanet.py | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/pyaptamer/aptanet/tests/test_aptanet.py b/pyaptamer/aptanet/tests/test_aptanet.py index a28ca849..1206c18d 100644 --- a/pyaptamer/aptanet/tests/test_aptanet.py +++ b/pyaptamer/aptanet/tests/test_aptanet.py @@ -25,7 +25,7 @@ def test_pipeline_fit_and_predict_classification(aptamer_seq, protein_seq): Test if Pipeline predictions are valid class labels and shape matches input for classification. """ - pipe = AptaNetPipeline() + pipe = AptaNetPipeline(k=4) X_raw = [(aptamer_seq, protein_seq) for _ in range(40)] y = np.array([0] * 20 + [1] * 20, dtype=np.float32) From 2fe0e9d8d1a42130a26c3a9fcb2b679eb25751a1 Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Wed, 10 Sep 2025 13:47:00 +0530 Subject: [PATCH 125/145] Update _base.py --- pyaptamer/benchmarking/_base.py | 68 ++++++++++++++++++++++++++------- 1 file changed, 55 insertions(+), 13 deletions(-) diff --git a/pyaptamer/benchmarking/_base.py b/pyaptamer/benchmarking/_base.py index 1b33dfbf..a753264e 100644 --- a/pyaptamer/benchmarking/_base.py +++ b/pyaptamer/benchmarking/_base.py @@ -1,3 +1,4 @@ +import numpy as np import pandas as pd from skbase.base import BaseObject from sklearn.model_selection import train_test_split @@ -11,16 +12,21 @@ class Benchmarking(BaseObject): with each estimator & evaluator. You can either: - (A) pass `datasets` (raw frames with columns ["aptamer","protein","y"]) - and let this class preprocess + split for you; or - (B) pass `train_datasets` and `test_datasets` + + - pass `datasets` (raw frames with columns ["aptamer","protein","y"] OR + preprocessed ["X","y"]) and let this class preprocess + split for you; or + - pass `train_datasets` and `test_datasets` which may be EITHER raw (["aptamer","protein","y"]) OR preprocessed (["X","y"]). + To input datasets, you should input a dictionary of DataFrames, with the format + being { "dataset_name": pd.DataFrame(...) }. Parameters ---------- estimators : list[estimator] | estimator + List of sklearn-like estimators with fit/predict. evaluators : list[callable] | callable + List of callables with signature (y_true, y_pred) -> float. task : str "classification" or "regression". preprocessor : BasePreprocessor | None @@ -47,7 +53,6 @@ def __init__( estimators, evaluators, task, - *, preprocessor=None, datasets=None, train_datasets=None, @@ -111,15 +116,14 @@ def _build_datasets(self): self._validate_xy(df, name=name) def _normalize_to_dict(self, data, prefix): + """Convert single DataFrame to dict or return existing dict.""" if data is None: return None if isinstance(data, pd.DataFrame): return {f"{prefix}_0": data} - if isinstance(data, list): - return {f"{prefix}_{i}": df for i, df in enumerate(data)} if isinstance(data, dict): return data - raise ValueError(f"Unsupported dataset type: {type(data)}") + raise ValueError(f"Data must be DataFrame or dict, {type(data)} given.") def _ensure_preprocessed(self, df): """ @@ -169,8 +173,8 @@ def _split_dataset(self, name, df): shuffle=True, ) - train_df = pd.DataFrame({"X": X_train, "y": y_train}).reset_index() - test_df = pd.DataFrame({"X": X_test, "y": y_test}).reset_index() + train_df = pd.DataFrame({"X": X_train, "y": y_train}).reset_index(drop=True) + test_df = pd.DataFrame({"X": X_test, "y": y_test}).reset_index(drop=True) train_name = f"{name}__train" test_name = f"{name}__test" @@ -184,7 +188,7 @@ def _validate_xy(self, df, name="dataset"): raise ValueError(f"{name} has mismatched X/y lengths.") if self.task == "classification": - # y should be discrete + df["y"] = df["y"].astype(int) if pd.api.types.is_numeric_dtype( df["y"] ) and not pd.api.types.is_integer_dtype(df["y"]): @@ -193,17 +197,36 @@ def _validate_xy(self, df, name="dataset"): "float." ) elif self.task == "regression": - # y should be numeric if not pd.api.types.is_numeric_dtype(df["y"]): raise ValueError(f"{name}: regression target y must be numeric.") return df[["X", "y"]] def _to_df(self, results): - """Convert nested dict results → dict of DataFrames and print neatly.""" + """ + Convert nested dict results to summary statistics and print detailed DataFrames. + + Returns + ------- + dict + Summary statistics containing: + - 'mean_scores': Average score per metric across all test sets + - 'best_model': Name of estimator with highest average performance + - 'best_score': Best score achieved + - 'per_estimator_stats': Dictionary of statistics per estimator + """ dfs = {} + summary_stats = { + "mean_scores": {}, + "best_model": None, + "best_score": 0, + "per_estimator_stats": {}, + } + for estimator, train_dict in results.items(): train_df_blocks = [] + estimator_scores = [] + for train_set, test_dict in train_dict.items(): df = pd.DataFrame(test_dict) # metrics × test_sets df["train_set"] = train_set @@ -211,13 +234,32 @@ def _to_df(self, results): df = df.reorder_levels(["train_set", df.index.names[0]]) train_df_blocks.append(df) + # Collect scores for summary + for metric in df.columns: + estimator_scores.extend(df[metric].values) + dfs[estimator] = pd.concat(train_df_blocks) + # Calculate per-estimator statistics + mean_score = np.mean(estimator_scores) + summary_stats["per_estimator_stats"][estimator] = { + "mean_score": mean_score, + "std_score": np.std(estimator_scores), + "max_score": np.max(estimator_scores), + "min_score": np.min(estimator_scores), + } + + # Track best model + if mean_score > summary_stats["best_score"]: + summary_stats["best_score"] = mean_score + summary_stats["best_model"] = estimator + + # Print detailed results for est, df in dfs.items(): print(f"\n=== {est} ===") print(df) - return dfs + return summary_stats def run(self): """ From e62a32b42a4955cc4dbcb6ab0afdf99e8b20c871 Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Thu, 11 Sep 2025 20:29:53 +0530 Subject: [PATCH 126/145] docstring changes --- pyaptamer/benchmarking/_base.py | 32 ++ pyaptamer/benchmarking/preprocessors/_base.py | 3 + .../benchmarking/preprocessors/aptanet.py | 31 ++ pyaptamer/utils/meta_classes.py | 24 +- pyaptamer/utils/tag_checks.py | 18 + x.ipynb | 359 ------------------ x.py | 36 -- 7 files changed, 104 insertions(+), 399 deletions(-) delete mode 100644 x.ipynb delete mode 100644 x.py diff --git a/pyaptamer/benchmarking/_base.py b/pyaptamer/benchmarking/_base.py index a753264e..884eccef 100644 --- a/pyaptamer/benchmarking/_base.py +++ b/pyaptamer/benchmarking/_base.py @@ -1,3 +1,6 @@ +__author__ = "satvshr" +__all__ = ["Benchmarking"] + import numpy as np import pandas as pd from skbase.base import BaseObject @@ -21,6 +24,7 @@ class Benchmarking(BaseObject): To input datasets, you should input a dictionary of DataFrames, with the format being { "dataset_name": pd.DataFrame(...) }. + Parameters ---------- estimators : list[estimator] | estimator @@ -44,6 +48,34 @@ class Benchmarking(BaseObject): (only when splitting). random_state : int | None Random state for reproducibility in splits. + + Example + ------- + >>> import pandas as pd + >>> from sklearn.metrics import accuracy_score + >>> from pyaptamer.benchmarking._base import Benchmarking + >>> from pyaptamer.aptanet import AptaNetPipeline + >>> from pyaptamer.benchmarking.preprocessors.aptanet import AptaNetPreprocessor + >>> from pyaptamer.datasets import load_csv_dataset + >>> df = load_csv_dataset( + ... "train_li2014" + ... ) # expects columns ['aptamer','protein','label'] + >>> df = df[:10] # smaller example + >>> df = df.rename(columns={"label": "y"}) + >>> df["y"] = df["y"].map({"negative": 0, "positive": 1}) + >>> pre = AptaNetPreprocessor() + >>> clf = AptaNetPipeline() + >>> bench = Benchmarking( + ... estimators=[clf], + ... evaluators=[accuracy_score], + ... task="classification", + ... preprocessor=pre, + ... datasets=df, + ... test_size=0.25, + ... stratify=True, + ... random_state=1337, + ... ) + >>> bench.run() """ _tags = {"tasks": ["classification", "regression"]} diff --git a/pyaptamer/benchmarking/preprocessors/_base.py b/pyaptamer/benchmarking/preprocessors/_base.py index ff2e53c7..9ff804c6 100644 --- a/pyaptamer/benchmarking/preprocessors/_base.py +++ b/pyaptamer/benchmarking/preprocessors/_base.py @@ -1,3 +1,6 @@ +__author__ = "satvshr" +__all__ = ["BasePreprocessor"] + import pandas as pd from pyaptamer.utils.meta_classes import NoNewPublicMethods diff --git a/pyaptamer/benchmarking/preprocessors/aptanet.py b/pyaptamer/benchmarking/preprocessors/aptanet.py index b5e8cfa1..f66ae3a4 100644 --- a/pyaptamer/benchmarking/preprocessors/aptanet.py +++ b/pyaptamer/benchmarking/preprocessors/aptanet.py @@ -1,9 +1,40 @@ +__author__ = "satvshr" +__all__ = ["AptaNetPreprocessor"] + from pyaptamer.benchmarking.preprocessors import BasePreprocessor from pyaptamer.utils._aptanet_utils import rna2dna class AptaNetPreprocessor(BasePreprocessor): + """ + Preprocessor for AptaNet benchmarking. + + Converts a pandas DataFrame with columns "aptamer", "protein" and "y" + into a DataFrame with columns "X" and "y" suitable for AptaNet pipelines. + + The returned "X" column contains tuples (aptamer_dna, protein) where + aptamer sequences are converted from RNA -> DNA via :func:`rna2dna`. + """ + def _transform(self, df): + """ + Transform input DataFrame into (X, y) format. + + Parameters + ---------- + df : pandas.DataFrame + Input dataframe with columns: + - 'aptamer' : str or sequence-like (RNA allowed) + - 'protein' : str (amino-acid sequence) + - 'y' : target labels + + Returns + ------- + pandas.DataFrame + DataFrame with columns: + - X : list of tuples (aptamer_dna, protein) + - y : original target column + """ df = df.copy() df["aptamer"] = df["aptamer"].apply(rna2dna) df["X"] = list(zip(df["aptamer"], df["protein"], strict=False)) diff --git a/pyaptamer/utils/meta_classes.py b/pyaptamer/utils/meta_classes.py index 7f865152..778b881f 100644 --- a/pyaptamer/utils/meta_classes.py +++ b/pyaptamer/utils/meta_classes.py @@ -1,8 +1,24 @@ +__author__ = "satvshr" +__all__ = ["NoNewPublicMethods"] + + class NoNewPublicMethods(type): - """A metaclass that prevents subclasses from: - 1. Adding new public methods. - 2. Overriding existing public methods. - Use with `metaclass=NoNewPublicMethods`. + """ + Metaclass that prevents subclasses from adding or overriding public methods. + + This metaclass enforces a stable public API: when a new subclass is created, + it will raise a TypeError if the subclass defines any new public methods + or overrides an existing public method defined on a base class. + + "Public" means any attribute name that does not start with a single + underscore. Private names (starting with '_') are allowed to be added or + overridden. + + Raises + ------ + TypeError + If a subclass defines new public methods or overrides existing public + methods from its base classes. """ def __init__(cls, name, bases, namespace): diff --git a/pyaptamer/utils/tag_checks.py b/pyaptamer/utils/tag_checks.py index fb7bb8d4..cc0c1065 100644 --- a/pyaptamer/utils/tag_checks.py +++ b/pyaptamer/utils/tag_checks.py @@ -1,7 +1,25 @@ +__author__ = "satvshr" +__all__ = ["task_check"] + """Add all `_tag` checking functions here.""" def task_check(estimator): + """ + Validate that an estimator's `task` is declared in its scikit-learn tags. + + Parameters + ---------- + estimator : object + An estimator object that implements `get_tags()` and exposes a + `.task` attribute indicating the intended task (e.g., "classification", + "regression"). + + Raises + ------ + ValueError + If `estimator.task` is not contained in the estimator's `"tasks"` tag. + """ tags = estimator.get_tags() if estimator.task not in tags["tasks"]: raise ValueError( diff --git a/x.ipynb b/x.ipynb deleted file mode 100644 index 48d68b5d..00000000 --- a/x.ipynb +++ /dev/null @@ -1,359 +0,0 @@ -{ - "cells": [ - { - "cell_type": "code", - "execution_count": 1, - "id": "44825503", - "metadata": {}, - "outputs": [], - "source": [ - "from pyaptamer.benchmarking import Benchmarking\n", - "from pyaptamer.benchmarking.preprocessors.aptanet import AptaNetPreprocessor\n", - "from pyaptamer.datasets import load_csv_dataset" - ] - }, - { - "cell_type": "code", - "execution_count": 2, - "id": "af9807c2", - "metadata": {}, - "outputs": [ - { - "name": "stdout", - "output_type": "stream", - "text": [ - " aptamer \\\n", - "0 UCGGAGGUGGUUCAGCUCUGCAUCGACAGUUGGC \n", - "1 CGGGGTGTTGTCCTGTGCTCTCCGGAGAGCACAGGACAACACCCCG \n", - "2 GCTGCAGTTGCACTGAATTCGCCTCTCGCCTCCGTACACTTAGTCG... \n", - "3 TATTTGCCCTTGCAGGCCGCAGGAGTGCTAGCAGT \n", - "4 UCUCUGGGCUCUUAGGAGAACGGAUAGGAGUGUGCUCGCU \n", - "... ... \n", - "2315 CGAUACAGCACUGAUUGCGGUCGAGGUAGCUUGAUGGGCC \n", - "2316 GATGTGGGTGTAGTTGGAGGGTAAACGTT \n", - "2317 ACATGTGATGATATATCGTGTCTCGTGATA \n", - "2318 GGGAGAGGAGGGAGAUAGAUAUCAAGAUAAAAACGCCGGCGUAGCG... \n", - "2319 CTTCTGCCCGCCTCCTTCCAGAGTAGCCAAGCGGAGAGTATTTTTG... \n", - "\n", - " protein label \n", - "0 MDSTNYISKLFEYAQRQGQISDIKFEEVGTDGPDHLKTFTLRVVIK... positive \n", - "1 MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSI... positive \n", - "2 MDEVGAQVAAPMFIHQSLGRKRDLYYPMSNRLVQSQPQRRDEWNSK... positive \n", - "3 PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGK... positive \n", - "4 LQENFLPQPRQQHHGTLVLHYRPHREEAGMQHPCLWPGSSHCSDDS... positive \n", - "... ... ... \n", - "2315 MANLGYWLLALFVTMWTDVGLCKKRPKPGGWNTGGSRYPGQGSPGG... negative \n", - "2316 MVKSHIGSWILVLFVAMWSDVGLCKKRPKPGGGWNTGGSRYPGQGS... negative \n", - "2317 MKKRKVLIPLMALSTILVSSTGNLEVIQAEVKQENRLLNESESSSQ... negative \n", - "2318 MASNFTQFVLVDNGGTGDVTVAPSNFANGVAEWISSNSRSQAYKVT... negative \n", - "2319 MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRTVM... negative \n", - "\n", - "[2320 rows x 3 columns]\n" - ] - } - ], - "source": [ - "print(load_csv_dataset(\"train_li2014\"))" - ] - }, - { - "cell_type": "code", - "execution_count": 3, - "id": "f41a9480", - "metadata": {}, - "outputs": [], - "source": [ - "# --- imports\n", - "from sklearn.metrics import accuracy_score, f1_score\n", - "\n", - "# AptaNetPipeline import (cover common locations)\n", - "from pyaptamer.aptanet import AptaNetPipeline\n", - "from pyaptamer.datasets import load_csv_dataset\n", - "\n", - "# --- load raw dataset (aptamer/protein/y)\n", - "df = load_csv_dataset(\"train_li2014\")\n", - "\n", - "# --- preprocessor\n", - "pre = AptaNetPreprocessor()\n", - "\n", - "# --- AptaNet model/pipeline (use defaults; tweak if you like)\n", - "clf = AptaNetPipeline()" - ] - }, - { - "cell_type": "code", - "execution_count": 4, - "id": "644f0222", - "metadata": {}, - "outputs": [ - { - "data": { - "text/html": [ - "
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aptamerproteinlabel
0UCGGAGGUGGUUCAGCUCUGCAUCGACAGUUGGCMDSTNYISKLFEYAQRQGQISDIKFEEVGTDGPDHLKTFTLRVVIK...positive
1CGGGGTGTTGTCCTGTGCTCTCCGGAGAGCACAGGACAACACCCCGMDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSI...positive
2GCTGCAGTTGCACTGAATTCGCCTCTCGCCTCCGTACACTTAGTCG...MDEVGAQVAAPMFIHQSLGRKRDLYYPMSNRLVQSQPQRRDEWNSK...positive
3TATTTGCCCTTGCAGGCCGCAGGAGTGCTAGCAGTPISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGK...positive
4UCUCUGGGCUCUUAGGAGAACGGAUAGGAGUGUGCUCGCULQENFLPQPRQQHHGTLVLHYRPHREEAGMQHPCLWPGSSHCSDDS...positive
\n", - "
" - ], - "text/plain": [ - " aptamer \\\n", - "0 UCGGAGGUGGUUCAGCUCUGCAUCGACAGUUGGC \n", - "1 CGGGGTGTTGTCCTGTGCTCTCCGGAGAGCACAGGACAACACCCCG \n", - "2 GCTGCAGTTGCACTGAATTCGCCTCTCGCCTCCGTACACTTAGTCG... \n", - "3 TATTTGCCCTTGCAGGCCGCAGGAGTGCTAGCAGT \n", - "4 UCUCUGGGCUCUUAGGAGAACGGAUAGGAGUGUGCUCGCU \n", - "\n", - " protein label \n", - "0 MDSTNYISKLFEYAQRQGQISDIKFEEVGTDGPDHLKTFTLRVVIK... positive \n", - "1 MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSI... positive \n", - "2 MDEVGAQVAAPMFIHQSLGRKRDLYYPMSNRLVQSQPQRRDEWNSK... positive \n", - "3 PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGK... positive \n", - "4 LQENFLPQPRQQHHGTLVLHYRPHREEAGMQHPCLWPGSSHCSDDS... positive " - ] - }, - "execution_count": 4, - "metadata": {}, - "output_type": "execute_result" - } - ], - "source": [ - "df.head()" - ] - }, - { - "cell_type": "code", - "execution_count": 5, - "id": "b9eb8099", - "metadata": {}, - "outputs": [ - { - "data": { - "text/html": [ - "
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aptamerproteiny
0UCGGAGGUGGUUCAGCUCUGCAUCGACAGUUGGCMDSTNYISKLFEYAQRQGQISDIKFEEVGTDGPDHLKTFTLRVVIK...1
1CGGGGTGTTGTCCTGTGCTCTCCGGAGAGCACAGGACAACACCCCGMDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSI...1
2GCTGCAGTTGCACTGAATTCGCCTCTCGCCTCCGTACACTTAGTCG...MDEVGAQVAAPMFIHQSLGRKRDLYYPMSNRLVQSQPQRRDEWNSK...1
3TATTTGCCCTTGCAGGCCGCAGGAGTGCTAGCAGTPISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGK...1
4UCUCUGGGCUCUUAGGAGAACGGAUAGGAGUGUGCUCGCULQENFLPQPRQQHHGTLVLHYRPHREEAGMQHPCLWPGSSHCSDDS...1
\n", - "
" - ], - "text/plain": [ - " aptamer \\\n", - "0 UCGGAGGUGGUUCAGCUCUGCAUCGACAGUUGGC \n", - "1 CGGGGTGTTGTCCTGTGCTCTCCGGAGAGCACAGGACAACACCCCG \n", - "2 GCTGCAGTTGCACTGAATTCGCCTCTCGCCTCCGTACACTTAGTCG... \n", - "3 TATTTGCCCTTGCAGGCCGCAGGAGTGCTAGCAGT \n", - "4 UCUCUGGGCUCUUAGGAGAACGGAUAGGAGUGUGCUCGCU \n", - "\n", - " protein y \n", - "0 MDSTNYISKLFEYAQRQGQISDIKFEEVGTDGPDHLKTFTLRVVIK... 1 \n", - "1 MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSI... 1 \n", - "2 MDEVGAQVAAPMFIHQSLGRKRDLYYPMSNRLVQSQPQRRDEWNSK... 1 \n", - "3 PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGK... 1 \n", - "4 LQENFLPQPRQQHHGTLVLHYRPHREEAGMQHPCLWPGSSHCSDDS... 1 " - ] - }, - "execution_count": 5, - "metadata": {}, - "output_type": "execute_result" - } - ], - "source": [ - "df = df.rename(columns={\"label\": \"y\"})\n", - "\n", - "# 2. Map values\n", - "df[\"y\"] = df[\"y\"].map({\"negative\": 0, \"positive\": 1})\n", - "\n", - "df.head()" - ] - }, - { - "cell_type": "code", - "execution_count": null, - "id": "6169daa2", - "metadata": {}, - "outputs": [ - { - "name": "stderr", - "output_type": "stream", - "text": [ - "c:\\Users\\satvm\\pyaptamer\\pyaptamer\\pseaac\\_features.py:229: UserWarning: Invalid amino acid(s) found in sequence. Replaced with 'N'.\n", - " protein_sequence = clean_protein_seq(protein_sequence)\n" - ] - }, - { - "name": "stdout", - "output_type": "stream", - "text": [ - "\n", - "=== AptaNetPipeline ===\n", - " dataset_0__test\n", - "train_set \n", - "dataset_0__train accuracy_score 1.0\n", - " f1_score 1.0\n" - ] - }, - { - "data": { - "text/plain": [ - "{'AptaNetPipeline': dataset_0__test\n", - " train_set \n", - " dataset_0__train accuracy_score 1.0\n", - " f1_score 1.0}" - ] - }, - "execution_count": 6, - "metadata": {}, - "output_type": "execute_result" - } - ], - "source": [ - "# --- set up the benchmark (auto split + stratify)\n", - "bench = Benchmarking(\n", - " estimators=[clf],\n", - " evaluators=[accuracy_score, f1_score],\n", - " task=\"classification\",\n", - " preprocessor=pre,\n", - " datasets=df[:10], # can also be [df1, df2] or {\"my_ds\": df}\n", - " test_size=0.25,\n", - " stratify=True,\n", - " random_state=1337,\n", - ")\n", - "\n", - "# --- run\n", - "results = bench.run()" - ] - }, - { - "cell_type": "code", - "execution_count": null, - "id": "146556ba", - "metadata": {}, - "outputs": [], - "source": [] - } - ], - "metadata": { - "kernelspec": { - "display_name": "pyaptamer-latest", - "language": "python", - "name": "python3" - }, - "language_info": { - "codemirror_mode": { - "name": "ipython", - "version": 3 - }, - "file_extension": ".py", - "mimetype": "text/x-python", - "name": "python", - "nbconvert_exporter": "python", - "pygments_lexer": "ipython3", - "version": "3.12.11" - } - }, - "nbformat": 4, - "nbformat_minor": 5 -} diff --git a/x.py b/x.py deleted file mode 100644 index e1ad6e0f..00000000 --- a/x.py +++ /dev/null @@ -1,36 +0,0 @@ -# --- imports -from sklearn.metrics import accuracy_score, f1_score - -# AptaNetPipeline import (cover common locations) -from pyaptamer.aptanet import AptaNetPipeline -from pyaptamer.benchmarking import Benchmarking -from pyaptamer.benchmarking.preprocessors.aptanet import AptaNetPreprocessor -from pyaptamer.datasets import load_csv_dataset - -# --- load raw dataset (aptamer/protein/y) -df = load_csv_dataset("train_li2014") - -# --- preprocessor -pre = AptaNetPreprocessor() - -# --- AptaNet model/pipeline (use defaults; tweak if you like) -clf = AptaNetPipeline() -df = df.rename(columns={"label": "y"}) - -# 2. Map values -df["y"] = df["y"].map({"negative": 0, "positive": 1}) - -# --- set up the benchmark (auto split + stratify) -bench = Benchmarking( - estimators=[clf], - evaluators=[accuracy_score, f1_score], - task="classification", - preprocessor=pre, - datasets=df, # can also be [df1, df2] or {"my_ds": df} - test_size=0.25, - stratify=True, - random_state=1337, -) - -# --- run -results = bench.run() From 45094f649498f3b6f7800cd3430a149ea02a015c Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Fri, 12 Sep 2025 12:52:55 +0530 Subject: [PATCH 127/145] Update _base.py --- pyaptamer/benchmarking/_base.py | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/pyaptamer/benchmarking/_base.py b/pyaptamer/benchmarking/_base.py index 884eccef..948dbd8d 100644 --- a/pyaptamer/benchmarking/_base.py +++ b/pyaptamer/benchmarking/_base.py @@ -75,7 +75,7 @@ class Benchmarking(BaseObject): ... stratify=True, ... random_state=1337, ... ) - >>> bench.run() + >>> summary = bench.run() """ _tags = {"tasks": ["classification", "regression"]} From e38770ed1d6d33893fc0662da87e87f6d9968c86 Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Mon, 15 Sep 2025 13:04:11 +0530 Subject: [PATCH 128/145] Update _base.py --- pyaptamer/benchmarking/_base.py | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/pyaptamer/benchmarking/_base.py b/pyaptamer/benchmarking/_base.py index 948dbd8d..2bb55e8a 100644 --- a/pyaptamer/benchmarking/_base.py +++ b/pyaptamer/benchmarking/_base.py @@ -75,7 +75,7 @@ class Benchmarking(BaseObject): ... stratify=True, ... random_state=1337, ... ) - >>> summary = bench.run() + >>> summary = bench.run() # doctest: +ELLIPSIS """ _tags = {"tasks": ["classification", "regression"]} From aa9677b57b8c2cbe3401d1a7522c92653265fc8a Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Mon, 15 Sep 2025 13:07:14 +0530 Subject: [PATCH 129/145] Update _base.py --- pyaptamer/benchmarking/_base.py | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/pyaptamer/benchmarking/_base.py b/pyaptamer/benchmarking/_base.py index 2bb55e8a..73947bbb 100644 --- a/pyaptamer/benchmarking/_base.py +++ b/pyaptamer/benchmarking/_base.py @@ -75,7 +75,7 @@ class Benchmarking(BaseObject): ... stratify=True, ... random_state=1337, ... ) - >>> summary = bench.run() # doctest: +ELLIPSIS + >>> summary = bench.run() # doctest: +SKIP """ _tags = {"tasks": ["classification", "regression"]} From 7e25cd457a7d33191b3dcdd4e30803fcfc20e2bb Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Tue, 16 Sep 2025 20:37:15 +0530 Subject: [PATCH 130/145] Added sklearn-like csv loader --- pyaptamer/datasets/_loaders/__init__.py | 3 +- pyaptamer/datasets/_loaders/_csv_loader.py | 59 ++++++++++++++------- pyaptamer/datasets/tests/test_csv_loader.py | 35 ++++++++++++ pyaptamer/datasets/tests/test_pfoa.py | 22 -------- 4 files changed, 78 insertions(+), 41 deletions(-) create mode 100644 pyaptamer/datasets/tests/test_csv_loader.py delete mode 100644 pyaptamer/datasets/tests/test_pfoa.py diff --git a/pyaptamer/datasets/_loaders/__init__.py b/pyaptamer/datasets/_loaders/__init__.py index 5fdc4143..c60a86e1 100644 --- a/pyaptamer/datasets/_loaders/__init__.py +++ b/pyaptamer/datasets/_loaders/__init__.py @@ -1,6 +1,7 @@ """Loaders for different data structures.""" +from pyaptamer.datasets._loaders._csv_loader import load_csv_dataset from pyaptamer.datasets._loaders._one_gnh import load_1gnh_structure from pyaptamer.datasets._loaders._pfoa_loader import load_pfoa_structure -__all__ = ["load_pfoa_structure", "load_1gnh_structure"] +__all__ = ["load_pfoa_structure", "load_1gnh_structure", "load_csv_dataset"] diff --git a/pyaptamer/datasets/_loaders/_csv_loader.py b/pyaptamer/datasets/_loaders/_csv_loader.py index 2d582525..ac1482e3 100644 --- a/pyaptamer/datasets/_loaders/_csv_loader.py +++ b/pyaptamer/datasets/_loaders/_csv_loader.py @@ -1,37 +1,60 @@ -__author__ = ["nennomp"] +__author__ = ["satvshr"] __all__ = ["load_csv_dataset"] import os import pandas as pd +from sklearn.utils import Bunch -def load_csv_dataset(name: str) -> pd.DataFrame: - """Load a dataset from a CSV file. +def load_csv_dataset(name, target_col, return_x_y=False): + """ + Load a dataset from a CSV file in a sklearn-like format. Parameters ---------- name : str - Name of the dataset to load. + Name of the dataset (file basename without `.csv`) located in the + package `dataset/data/` directory. + target_col : str, optional, default="label" + Column name in the CSV to use as the target variable. + return_x_y : bool, optional, default=False + If True, return (X, y) as NumPy arrays. If False, return a sklearn.utils.Bunch + with attributes similar to sklearn dataset loaders. Returns ------- - pandas.DataFrame - A DataFrame containing the dataset loaded from the CSV file. - - Raises - ------ - FileNotFoundError - If the specified CSV file does not exist. + sklearn.utils.Bunch or tuple of np.ndarray + If `return_x_y` is False, returns a Bunch with fields: + - data: ndarray of shape (n_samples, n_features) + - target: ndarray of shape (n_samples,) + - frame: pandas.DataFrame (the loaded DataFrame) + - feature_names: list[str] (column names used as features) + - target_name: str (the name of the target column) + - filename: str (resolved path to the CSV file) + If `return_x_y` is True, returns (X, y) where: + - X : ndarray of shape (n_samples, n_features) built by dropping the target + column + - y : ndarray of shape (n_samples,) from the target column """ path = os.path.relpath( os.path.join(os.path.dirname(__file__), "..", "data", f"{name}.csv") ) - if os.path.exists(path): - dataset = pd.read_csv(path) - return dataset - else: - raise FileNotFoundError( - f"Dataset {name} not found at {path}. Please ensure the file exists." - ) + df = pd.read_csv(path) + + X = df.drop(columns=[target_col]).to_numpy() + y = df[target_col].to_numpy() + + if return_x_y: + return X, y + + bunch = Bunch( + data=X, + target=y, + frame=df, + feature_names=list(X.columns), + target_name=target_col, + filename=path, + ) + return bunch diff --git a/pyaptamer/datasets/tests/test_csv_loader.py b/pyaptamer/datasets/tests/test_csv_loader.py new file mode 100644 index 00000000..6648cacf --- /dev/null +++ b/pyaptamer/datasets/tests/test_csv_loader.py @@ -0,0 +1,35 @@ +__author__ = "satvshr" + +import numpy as np +from sklearn.utils import Bunch + +from pyaptamer.datasets._loaders._csv_loader import load_csv_dataset + +DATASET_NAME = "train_li2014" +TARGET_COL = "label" + + +def test_load_csv_return_x_y(): + """ + When return_x_y=True the loader should return two numpy arrays (X, y). + """ + X, y = load_csv_dataset(DATASET_NAME, target_col=TARGET_COL, return_x_y=True) + + assert isinstance(X, np.ndarray), "X should be a numpy array" + assert isinstance(y, np.ndarray), "y should be a numpy array" + assert X.shape[0] == y.shape[0], "Number of samples in X and y must match" + assert X.ndim == 2, "X should be a 2D array (n_samples, n_features)" + + +def test_load_csv_returns_bunch(): + """ + When return_x_y=False the loader should return a sklearn.utils.Bunch-like object + containing data, target and frame. + """ + bunch = load_csv_dataset(DATASET_NAME, target_col=TARGET_COL, return_x_y=False) + + assert isinstance(bunch, Bunch), "Returned object should be a sklearn.utils.Bunch" + assert bunch.data.shape[0] == len(bunch.frame), ( + "data length must match number of rows in frame" + ) + assert bunch.target_name == TARGET_COL diff --git a/pyaptamer/datasets/tests/test_pfoa.py b/pyaptamer/datasets/tests/test_pfoa.py deleted file mode 100644 index 14eec9d0..00000000 --- a/pyaptamer/datasets/tests/test_pfoa.py +++ /dev/null @@ -1,22 +0,0 @@ -__author__ = "satvshr" - -from Bio.PDB.Structure import Structure - -from pyaptamer.datasets._loaders import load_pfoa_structure - - -def test_pfoa_loader(): - """ - Test that the load_pfoa_structure function runs without error and returns a valid - Structure object. - - Asserts - ------- - The datasets loads and the return value must be an instance of Biopython's - Structure class. - """ - structure = load_pfoa_structure() - - assert isinstance(structure, Structure), ( - "Returned object is not a Biopython Structure" - ) From 04663105cdb1a30adf58ee40651dd0e675e2bfbb Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Tue, 16 Sep 2025 23:16:44 +0530 Subject: [PATCH 131/145] Making requested changes --- pyaptamer/benchmarking/_base.py | 426 +++++++----------- .../benchmarking/preprocessors/__init__.py | 5 - pyaptamer/benchmarking/preprocessors/_base.py | 94 ---- .../benchmarking/preprocessors/aptanet.py | 41 -- pyaptamer/datasets/_loaders/_csv_loader.py | 2 +- pyaptamer/utils/meta_classes.py | 51 --- 6 files changed, 170 insertions(+), 449 deletions(-) delete mode 100644 pyaptamer/benchmarking/preprocessors/__init__.py delete mode 100644 pyaptamer/benchmarking/preprocessors/_base.py delete mode 100644 pyaptamer/benchmarking/preprocessors/aptanet.py delete mode 100644 pyaptamer/utils/meta_classes.py diff --git a/pyaptamer/benchmarking/_base.py b/pyaptamer/benchmarking/_base.py index 73947bbb..656a4d90 100644 --- a/pyaptamer/benchmarking/_base.py +++ b/pyaptamer/benchmarking/_base.py @@ -4,78 +4,78 @@ import numpy as np import pandas as pd from skbase.base import BaseObject -from sklearn.model_selection import train_test_split +from sklearn.model_selection import check_cv, train_test_split from pyaptamer.utils.tag_checks import task_check class Benchmarking(BaseObject): """ - Train on each train dataset and evaluate on every test dataset - with each estimator & evaluator. + Benchmark estimators on train/test splits or cross-validation. You can either: - - pass `datasets` (raw frames with columns ["aptamer","protein","y"] OR - preprocessed ["X","y"]) and let this class preprocess + split for you; or - - pass `train_datasets` and `test_datasets` - which may be EITHER raw (["aptamer","protein","y"]) OR preprocessed - (["X","y"]). - - To input datasets, you should input a dictionary of DataFrames, with the format - being { "dataset_name": pd.DataFrame(...) }. + - pass `X, y` (feature matrix and labels/targets) and let this class + split into train/test for you (if cv=None); or + - pass explicit `train_X, train_y, test_X, test_y` (if cv=None); or + - pass `X, y` along with `cv` to use cross-validation. Parameters ---------- estimators : list[estimator] | estimator - List of sklearn-like estimators with fit/predict. + List of sklearn-like estimators implementing `fit` and `predict`. evaluators : list[callable] | callable - List of callables with signature (y_true, y_pred) -> float. - task : str - "classification" or "regression". - preprocessor : BasePreprocessor | None - Used to convert raw ["aptamer","protein","y"] -> ["X","y"] when needed. - datasets : dict[str, pd.DataFrame] | None - Raw datasets to be split into train/test (if provided). - train_datasets : dict[str, pd.DataFrame] | None - Training datasets (raw or preprocessed). - test_datasets : dict[str, pd.DataFrame] | None - Test datasets (raw or preprocessed). - test_size : float - Fraction for the test split when using `datasets`. - stratify : bool - If True and task=="classification", use y for stratification - (only when splitting). - random_state : int | None + List of callables with signature ``(y_true, y_pred) -> float``. + X : array-like, optional + Feature matrix. Used together with `y` if explicit train/test splits + are not provided. + y : array-like, optional + Target vector. Used together with `X` if explicit train/test splits + are not provided. + train_X : array-like, optional + Training feature matrix (ignored if `cv` is given). + train_y : array-like, optional + Training labels/targets (ignored if `cv` is given). + test_X : array-like, optional + Test feature matrix (ignored if `cv` is given). + test_y : array-like, optional + Test labels/targets (ignored if `cv` is given). + test_size : float, default=0.2 + Fraction of data to reserve for the test split when splitting `X, y`. + Ignored if `cv` is provided. + stratify : bool, default=True + If True, and the task is classification, stratify the train/test split + using `y`. Ignored if `cv` is provided. + random_state : int or None, default=42 Random state for reproducibility in splits. + cv : int, CV splitter, or None, default=None + Cross-validation strategy. If provided, results are averaged + across folds and returned in the same format as hold-out mode. + + Attributes + ---------- + results : pd.DataFrame + Results table after calling :meth:`run`. + + - Rows = MultiIndex (estimator, metric) + - Cols = ["train", "test"] Example ------- - >>> import pandas as pd >>> from sklearn.metrics import accuracy_score - >>> from pyaptamer.benchmarking._base import Benchmarking - >>> from pyaptamer.aptanet import AptaNetPipeline - >>> from pyaptamer.benchmarking.preprocessors.aptanet import AptaNetPreprocessor - >>> from pyaptamer.datasets import load_csv_dataset - >>> df = load_csv_dataset( - ... "train_li2014" - ... ) # expects columns ['aptamer','protein','label'] - >>> df = df[:10] # smaller example - >>> df = df.rename(columns={"label": "y"}) - >>> df["y"] = df["y"].map({"negative": 0, "positive": 1}) - >>> pre = AptaNetPreprocessor() - >>> clf = AptaNetPipeline() + >>> from sklearn.linear_model import LogisticRegression + >>> from sklearn.datasets import make_classification + >>> X, y = make_classification(n_samples=100, n_features=20, random_state=0) >>> bench = Benchmarking( - ... estimators=[clf], + ... estimators=[LogisticRegression(max_iter=1000)], ... evaluators=[accuracy_score], - ... task="classification", - ... preprocessor=pre, - ... datasets=df, - ... test_size=0.25, - ... stratify=True, - ... random_state=1337, + ... X=X, + ... y=y, + ... test_size=0.3, + ... random_state=42, ... ) - >>> summary = bench.run() # doctest: +SKIP + >>> results = bench.run() + >>> print(results) """ _tags = {"tasks": ["classification", "regression"]} @@ -84,119 +84,56 @@ def __init__( self, estimators, evaluators, - task, - preprocessor=None, - datasets=None, - train_datasets=None, - test_datasets=None, + X=None, + y=None, + train_X=None, + train_y=None, + test_X=None, + test_y=None, test_size=0.2, stratify=True, random_state=42, + cv=None, ): self.estimators = estimators if isinstance(estimators, list) else [estimators] self.evaluators = evaluators if isinstance(evaluators, list) else [evaluators] - self.task = task - self.preprocessor = preprocessor self.test_size = test_size - self.stratify_flag = stratify + self.stratify = stratify self.random_state = random_state - - # accept either (datasets) or (train/test) - # normalize datasets to dict - self._raw_datasets = self._normalize_to_dict(datasets, prefix="dataset") - self._train_datasets_in = self._normalize_to_dict( - train_datasets, prefix="train" - ) - self._test_datasets_in = self._normalize_to_dict(test_datasets, prefix="test") - - # prepared containers - self.train_datasets = {} - self.test_datasets = {} - - self.results = None - - # prepare datasets immediately - self._build_datasets() - - def _build_datasets(self): - """ - Build self.train_datasets and self.test_datasets from provided inputs. - """ - # case A: user provided raw datasets to split - if self._raw_datasets is not None: - for name, df in self._raw_datasets.items(): - train, test, train_name, test_name = self._split_dataset(name, df) - self.train_datasets[train_name] = train - self.test_datasets[test_name] = test - - # case B: user provided train/test datasets (each may be raw or preprocessed) - if self._train_datasets_in is not None: - for name, df in self._train_datasets_in.items(): - self.train_datasets[name] = self._ensure_preprocessed(df) - - if self._test_datasets_in is not None: - for name, df in self._test_datasets_in.items(): - self.test_datasets[name] = self._ensure_preprocessed(df) - - if not self.train_datasets or not self.test_datasets: - raise ValueError( - "No datasets prepared. Provide either `datasets` to split or " - "`train_datasets` and `test_datasets` (raw or with ['X','y'])." - ) - - for name, df in {**self.train_datasets, **self.test_datasets}.items(): - self._validate_xy(df, name=name) - - def _normalize_to_dict(self, data, prefix): - """Convert single DataFrame to dict or return existing dict.""" - if data is None: - return None - if isinstance(data, pd.DataFrame): - return {f"{prefix}_0": data} - if isinstance(data, dict): - return data - raise ValueError(f"Data must be DataFrame or dict, {type(data)} given.") - - def _ensure_preprocessed(self, df): - """ - Ensure df has only ["X","y"]. - - If extra columns are present, warn and return only ["X","y"]. - - If missing, run the preprocessor and reduce to ["X","y"]. - """ - import warnings - - if {"X", "y"}.issubset(df.columns): - if set(df.columns) != {"X", "y"}: - warnings.warn( - f"Extra columns {set(df.columns) - {'X', 'y'}} found. " - "Only ['X','y'] will be kept.", - stacklevel=2, + self.cv = cv + + if self.cv is None: + if X is not None and y is not None: + ( + self.train_X, + self.test_X, + self.train_y, + self.test_y, + ) = self._split_dataset(X, y) + elif ( + train_X is not None + and train_y is not None + and test_X is not None + and test_y is not None + ): + self.train_X, self.train_y = train_X, train_y + self.test_X, self.test_y = test_X, test_y + else: + raise ValueError( + "Provide either (X, y) or (train_X, train_y, test_X, test_y)" + "when cv=None." ) - return df[["X", "y"]] - - if self.preprocessor is None: - raise ValueError( - "Input DataFrame does not have ['X','y'] and no preprocessor" - "was provided." - ) - - df_proc = self.preprocessor.transform(df) - return df_proc[["X", "y"]] - - def _split_dataset(self, name, df): - """ - Split a single dataset into train/test and return preprocessed splits. - Works whether `df` is raw or already preprocessed. - Returns (train_df, test_df, train_name, test_name). - """ - df_proc = self._ensure_preprocessed(df) - X, y = df_proc["X"], df_proc["y"] + else: + if X is None or y is None: + raise ValueError("Provide (X, y) when using cross-validation.") + self.X, self.y = X, y - stratify_vec = ( - y if (self.task == "classification" and self.stratify_flag) else None - ) + self.results = None - X_train, X_test, y_train, y_test = train_test_split( + def _split_dataset(self, X, y): + """Split into train/test arrays.""" + stratify_vec = y if self.stratify else None + return train_test_split( X, y, test_size=self.test_size, @@ -205,132 +142,107 @@ def _split_dataset(self, name, df): shuffle=True, ) - train_df = pd.DataFrame({"X": X_train, "y": y_train}).reset_index(drop=True) - test_df = pd.DataFrame({"X": X_test, "y": y_test}).reset_index(drop=True) - - train_name = f"{name}__train" - test_name = f"{name}__test" - return train_df, test_df, train_name, test_name - - def _validate_xy(self, df, name="dataset"): - if not {"X", "y"}.issubset(df.columns): - raise ValueError(f"{name} is missing required columns ['X','y'].") - - if len(df["X"]) != len(df["y"]): - raise ValueError(f"{name} has mismatched X/y lengths.") - - if self.task == "classification": - df["y"] = df["y"].astype(int) - if pd.api.types.is_numeric_dtype( - df["y"] - ) and not pd.api.types.is_integer_dtype(df["y"]): - raise ValueError( - f"{name}: classification target y must be categorical/integer, not" - "float." - ) - elif self.task == "regression": - if not pd.api.types.is_numeric_dtype(df["y"]): - raise ValueError(f"{name}: regression target y must be numeric.") - - return df[["X", "y"]] - def _to_df(self, results): - """ - Convert nested dict results to summary statistics and print detailed DataFrames. + """Convert nested results to a unified DataFrame.""" + records = [] + index = [] - Returns - ------- - dict - Summary statistics containing: - - 'mean_scores': Average score per metric across all test sets - - 'best_model': Name of estimator with highest average performance - - 'best_score': Best score achieved - - 'per_estimator_stats': Dictionary of statistics per estimator - """ - dfs = {} - summary_stats = { - "mean_scores": {}, - "best_model": None, - "best_score": 0, - "per_estimator_stats": {}, - } - - for estimator, train_dict in results.items(): - train_df_blocks = [] - estimator_scores = [] - - for train_set, test_dict in train_dict.items(): - df = pd.DataFrame(test_dict) # metrics × test_sets - df["train_set"] = train_set - df = df.set_index(["train_set"], append=True) - df = df.reorder_levels(["train_set", df.index.names[0]]) - train_df_blocks.append(df) - - # Collect scores for summary - for metric in df.columns: - estimator_scores.extend(df[metric].values) - - dfs[estimator] = pd.concat(train_df_blocks) - - # Calculate per-estimator statistics - mean_score = np.mean(estimator_scores) - summary_stats["per_estimator_stats"][estimator] = { - "mean_score": mean_score, - "std_score": np.std(estimator_scores), - "max_score": np.max(estimator_scores), - "min_score": np.min(estimator_scores), - } - - # Track best model - if mean_score > summary_stats["best_score"]: - summary_stats["best_score"] = mean_score - summary_stats["best_model"] = estimator - - # Print detailed results - for est, df in dfs.items(): - print(f"\n=== {est} ===") - print(df) - - return summary_stats + for est_name, est_scores in results.items(): + for metric_name, scores in est_scores.items(): + records.append(scores) + index.append((est_name, metric_name)) + + index = pd.MultiIndex.from_tuples(index, names=["estimator", "metric"]) + return pd.DataFrame(records, index=index, columns=["train", "test"]) def run(self): """ - Train each estimator on each training dataset and evaluate on all test datasets. + Train each estimator and evaluate with hold-out or cross-validation. Returns ------- - dict[str, pd.DataFrame] - Mapping estimator_name -> DataFrame of metrics - (rows = train_set, cols = test_sets). + pd.DataFrame + Results table with rows = (estimator, metric), + cols = ["train", "test"]. """ import copy + from sklearn.base import clone + task_check(self) - results = {} - for estimator in self.estimators: - estimator_name = estimator.__class__.__name__ - results[estimator_name] = {} + results = {} - for train_name, train_df in self.train_datasets.items(): + if self.cv is not None: + # Cross-validation mode + cv = check_cv(self.cv, y=self.y, classifier=None) + + for estimator in self.estimators: + est_name = estimator.__class__.__name__ + metric_scores = { + metric.__name__: {"train": [], "test": []} + for metric in self.evaluators + } + + for train_idx, test_idx in cv.split(self.X, self.y): + X_train, X_test = self.X[train_idx], self.X[test_idx] + y_train, y_test = self.y[train_idx], self.y[test_idx] + + model = clone(estimator) + model.fit(X_train, y_train) + + # evaluate on both train and test fold parts + for split_name, (X_split, y_split) in { + "train": (X_train, y_train), + "test": (X_test, y_test), + }.items(): + y_pred = model.predict(X_split) + for evaluator in self.evaluators: + eval_name = getattr( + evaluator, + "__name__", + getattr( + evaluator, "name", evaluator.__class__.__name__ + ), + ) + metric_scores[eval_name][split_name].append( + evaluator(y_split, y_pred) + ) + + # average across folds + results[est_name] = { + metric: { + "train": float(np.mean(scores["train"])), + "test": float(np.mean(scores["test"])), + } + for metric, scores in metric_scores.items() + } + + else: + # Hold-out mode + for estimator in self.estimators: + est_name = estimator.__class__.__name__ model = copy.deepcopy(estimator) - model.fit(train_df["X"], train_df["y"]) - results[estimator_name][train_name] = {} - - for test_name, test_df in self.test_datasets.items(): - y_true = test_df["y"] - y_pred = model.predict(test_df["X"]) - test_results = {} - + model.fit(self.train_X, self.train_y) + + est_scores = {} + for split_name, (X_split, y_split) in { + "train": (self.train_X, self.train_y), + "test": (self.test_X, self.test_y), + }.items(): + y_pred = model.predict(X_split) + scores = {} for evaluator in self.evaluators: - evaluator_name = getattr( + eval_name = getattr( evaluator, "__name__", getattr(evaluator, "name", evaluator.__class__.__name__), ) - test_results[evaluator_name] = evaluator(y_true, y_pred) + scores[eval_name] = evaluator(y_split, y_pred) + for eval_name, score in scores.items(): + est_scores.setdefault(eval_name, {})[split_name] = score - results[estimator_name][train_name][test_name] = test_results + results[est_name] = est_scores self.results = self._to_df(results) return self.results diff --git a/pyaptamer/benchmarking/preprocessors/__init__.py b/pyaptamer/benchmarking/preprocessors/__init__.py deleted file mode 100644 index 88633968..00000000 --- a/pyaptamer/benchmarking/preprocessors/__init__.py +++ /dev/null @@ -1,5 +0,0 @@ -"""Preprocessing for the benchmarking module.""" - -from pyaptamer.benchmarking.preprocessors._base import BasePreprocessor - -__all__ = ["BasePreprocessor"] diff --git a/pyaptamer/benchmarking/preprocessors/_base.py b/pyaptamer/benchmarking/preprocessors/_base.py deleted file mode 100644 index 9ff804c6..00000000 --- a/pyaptamer/benchmarking/preprocessors/_base.py +++ /dev/null @@ -1,94 +0,0 @@ -__author__ = "satvshr" -__all__ = ["BasePreprocessor"] - -import pandas as pd - -from pyaptamer.utils.meta_classes import NoNewPublicMethods - - -class BasePreprocessor(metaclass=NoNewPublicMethods): - """ - Base class for all preprocessors. - - A preprocessor takes a pandas DataFrame with columns "aptamer", "protein", - and "y", and converts it into a DataFrame with columns "X" (features) - and "y" (target). - - The exact conversion logic depends on the algorithm being processed. - """ - - def _ensure_format(self, df, required_cols, only_required_cols=False): - """ - Ensure input is a DataFrame with the required columns. - - Parameters - ---------- - df : pandas.DataFrame or dict-like - Input data. - required_cols : iterable of str - Column names that must be present. - only_required_cols : bool, default=False - If True, return a DataFrame with only the required columns. - - Returns - ------- - df : pandas.DataFrame - Validated DataFrame. - - Raises - ------ - ValueError - If required columns are missing. - """ - if not isinstance(df, pd.DataFrame): - df = pd.DataFrame(df) - - if required_cols is not None: - missing = set(required_cols) - set(df.columns) - if missing: - raise ValueError(f"DataFrame is missing columns: {missing}") - - if only_required_cols and required_cols is not None: - return df[required_cols] - - return df - - def transform(self, df, only_required_cols=True): - """ - Transform input DataFrame into feature/target representation. - - Parameters - ---------- - df : pandas.DataFrame - Must contain "aptamer", "protein", and "y" columns. - only_required_cols_cols : bool, default=True - If True, return only the required columns ["X","y"] at the end. - - Returns - ------- - df : pandas.DataFrame - Must contain "X" (features) and "y" (target) columns. - """ - df = self._ensure_format(df, required_cols=["aptamer", "protein", "y"]) - df = self._transform(df) - df = self._ensure_format( - df, required_cols=["X", "y"], only_required_cols=only_required_cols - ) - - return df - - def _transform(self, df): - """ - Apply subclass-specific preprocessing. - - Parameters - ---------- - df : pandas.DataFrame - Input DataFrame with "aptamer", "protein", "y". - - Returns - ------- - df : pandas.DataFrame - Transformed DataFrame with "X" and "y". - """ - raise NotImplementedError("Subclasses must implement `_transform`.") diff --git a/pyaptamer/benchmarking/preprocessors/aptanet.py b/pyaptamer/benchmarking/preprocessors/aptanet.py deleted file mode 100644 index f66ae3a4..00000000 --- a/pyaptamer/benchmarking/preprocessors/aptanet.py +++ /dev/null @@ -1,41 +0,0 @@ -__author__ = "satvshr" -__all__ = ["AptaNetPreprocessor"] - -from pyaptamer.benchmarking.preprocessors import BasePreprocessor -from pyaptamer.utils._aptanet_utils import rna2dna - - -class AptaNetPreprocessor(BasePreprocessor): - """ - Preprocessor for AptaNet benchmarking. - - Converts a pandas DataFrame with columns "aptamer", "protein" and "y" - into a DataFrame with columns "X" and "y" suitable for AptaNet pipelines. - - The returned "X" column contains tuples (aptamer_dna, protein) where - aptamer sequences are converted from RNA -> DNA via :func:`rna2dna`. - """ - - def _transform(self, df): - """ - Transform input DataFrame into (X, y) format. - - Parameters - ---------- - df : pandas.DataFrame - Input dataframe with columns: - - 'aptamer' : str or sequence-like (RNA allowed) - - 'protein' : str (amino-acid sequence) - - 'y' : target labels - - Returns - ------- - pandas.DataFrame - DataFrame with columns: - - X : list of tuples (aptamer_dna, protein) - - y : original target column - """ - df = df.copy() - df["aptamer"] = df["aptamer"].apply(rna2dna) - df["X"] = list(zip(df["aptamer"], df["protein"], strict=False)) - return df[["X", "y"]] diff --git a/pyaptamer/datasets/_loaders/_csv_loader.py b/pyaptamer/datasets/_loaders/_csv_loader.py index ac1482e3..825a842a 100644 --- a/pyaptamer/datasets/_loaders/_csv_loader.py +++ b/pyaptamer/datasets/_loaders/_csv_loader.py @@ -16,7 +16,7 @@ def load_csv_dataset(name, target_col, return_x_y=False): name : str Name of the dataset (file basename without `.csv`) located in the package `dataset/data/` directory. - target_col : str, optional, default="label" + target_col : str Column name in the CSV to use as the target variable. return_x_y : bool, optional, default=False If True, return (X, y) as NumPy arrays. If False, return a sklearn.utils.Bunch diff --git a/pyaptamer/utils/meta_classes.py b/pyaptamer/utils/meta_classes.py deleted file mode 100644 index 778b881f..00000000 --- a/pyaptamer/utils/meta_classes.py +++ /dev/null @@ -1,51 +0,0 @@ -__author__ = "satvshr" -__all__ = ["NoNewPublicMethods"] - - -class NoNewPublicMethods(type): - """ - Metaclass that prevents subclasses from adding or overriding public methods. - - This metaclass enforces a stable public API: when a new subclass is created, - it will raise a TypeError if the subclass defines any new public methods - or overrides an existing public method defined on a base class. - - "Public" means any attribute name that does not start with a single - underscore. Private names (starting with '_') are allowed to be added or - overridden. - - Raises - ------ - TypeError - If a subclass defines new public methods or overrides existing public - methods from its base classes. - """ - - def __init__(cls, name, bases, namespace): - # if the only base is object, allow free definition (root class) - if all(base is object for base in bases): - super().__init__(name, bases, namespace) - return - - # collect all allowed public methods from bases - allowed = {} - for base in bases: - for attr_name, attr_val in base.__dict__.items(): - if callable(attr_val) and not attr_name.startswith("_"): - allowed[attr_name] = attr_val - - # check the new class namespace - for attr_name, attr_val in namespace.items(): - if callable(attr_val) and not attr_name.startswith("_"): - if attr_name not in allowed: - raise TypeError( - f"Class {name} is not allowed to define new " - f"public method '{attr_name}'" - ) - elif attr_val is not allowed[attr_name]: - raise TypeError( - f"Class {name} is not allowed to override " - f"existing public method '{attr_name}'" - ) - - super().__init__(name, bases, namespace) From efb6fcff2a8262740411e22db0738667d8195736 Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Wed, 17 Sep 2025 13:48:54 +0530 Subject: [PATCH 132/145] cleaned up code --- pyaptamer/benchmarking/_base.py | 51 ++++++++++------------ pyaptamer/datasets/_loaders/_csv_loader.py | 12 ++--- 2 files changed, 30 insertions(+), 33 deletions(-) diff --git a/pyaptamer/benchmarking/_base.py b/pyaptamer/benchmarking/_base.py index 656a4d90..bd6dcc6e 100644 --- a/pyaptamer/benchmarking/_base.py +++ b/pyaptamer/benchmarking/_base.py @@ -1,6 +1,8 @@ __author__ = "satvshr" __all__ = ["Benchmarking"] +import copy + import numpy as np import pandas as pd from skbase.base import BaseObject @@ -62,20 +64,24 @@ class Benchmarking(BaseObject): Example ------- + >>> import pandas as pd + >>> import numpy as np >>> from sklearn.metrics import accuracy_score - >>> from sklearn.linear_model import LogisticRegression - >>> from sklearn.datasets import make_classification - >>> X, y = make_classification(n_samples=100, n_features=20, random_state=0) + >>> from pyaptamer.benchmarking._base import Benchmarking + >>> from pyaptamer.aptanet import AptaNetPipeline + >>> from pyaptamer.datasets import load_csv_dataset + >>> X, y = load_csv_dataset("train_li2014", "label", return_X_y=True) + >>> X = X[:10] # smaller example + >>> y = y[:10] + >>> y = np.where(y == "positive", 1, 0) + >>> clf = AptaNetPipeline() >>> bench = Benchmarking( - ... estimators=[LogisticRegression(max_iter=1000)], + ... estimators=[clf], ... evaluators=[accuracy_score], ... X=X, ... y=y, - ... test_size=0.3, - ... random_state=42, ... ) - >>> results = bench.run() - >>> print(results) + >>> summary = bench.run() # doctest: +SKIP """ _tags = {"tasks": ["classification", "regression"]} @@ -92,7 +98,7 @@ def __init__( test_y=None, test_size=0.2, stratify=True, - random_state=42, + random_state=None, cv=None, ): self.estimators = estimators if isinstance(estimators, list) else [estimators] @@ -109,7 +115,14 @@ def __init__( self.test_X, self.train_y, self.test_y, - ) = self._split_dataset(X, y) + ) = train_test_split( + X, + y, + test_size=self.test_size, + random_state=self.random_state, + stratify=y if self.stratify else None, + shuffle=True, + ) elif ( train_X is not None and train_y is not None @@ -130,18 +143,6 @@ def __init__( self.results = None - def _split_dataset(self, X, y): - """Split into train/test arrays.""" - stratify_vec = y if self.stratify else None - return train_test_split( - X, - y, - test_size=self.test_size, - random_state=self.random_state, - stratify=stratify_vec, - shuffle=True, - ) - def _to_df(self, results): """Convert nested results to a unified DataFrame.""" records = [] @@ -165,10 +166,6 @@ def run(self): Results table with rows = (estimator, metric), cols = ["train", "test"]. """ - import copy - - from sklearn.base import clone - task_check(self) results = {} @@ -188,7 +185,7 @@ def run(self): X_train, X_test = self.X[train_idx], self.X[test_idx] y_train, y_test = self.y[train_idx], self.y[test_idx] - model = clone(estimator) + model = copy.deepcopy(estimator) model.fit(X_train, y_train) # evaluate on both train and test fold parts diff --git a/pyaptamer/datasets/_loaders/_csv_loader.py b/pyaptamer/datasets/_loaders/_csv_loader.py index 825a842a..9c8cc58b 100644 --- a/pyaptamer/datasets/_loaders/_csv_loader.py +++ b/pyaptamer/datasets/_loaders/_csv_loader.py @@ -7,7 +7,7 @@ from sklearn.utils import Bunch -def load_csv_dataset(name, target_col, return_x_y=False): +def load_csv_dataset(name, target_col, return_X_y=False): """ Load a dataset from a CSV file in a sklearn-like format. @@ -18,21 +18,21 @@ def load_csv_dataset(name, target_col, return_x_y=False): package `dataset/data/` directory. target_col : str Column name in the CSV to use as the target variable. - return_x_y : bool, optional, default=False + return_X_y : bool, optional, default=False If True, return (X, y) as NumPy arrays. If False, return a sklearn.utils.Bunch with attributes similar to sklearn dataset loaders. Returns ------- sklearn.utils.Bunch or tuple of np.ndarray - If `return_x_y` is False, returns a Bunch with fields: + If `return_X_y` is False, returns a Bunch with fields: - data: ndarray of shape (n_samples, n_features) - target: ndarray of shape (n_samples,) - frame: pandas.DataFrame (the loaded DataFrame) - feature_names: list[str] (column names used as features) - target_name: str (the name of the target column) - filename: str (resolved path to the CSV file) - If `return_x_y` is True, returns (X, y) where: + If `return_X_y` is True, returns (X, y) where: - X : ndarray of shape (n_samples, n_features) built by dropping the target column - y : ndarray of shape (n_samples,) from the target column @@ -46,14 +46,14 @@ def load_csv_dataset(name, target_col, return_x_y=False): X = df.drop(columns=[target_col]).to_numpy() y = df[target_col].to_numpy() - if return_x_y: + if return_X_y: return X, y bunch = Bunch( data=X, target=y, frame=df, - feature_names=list(X.columns), + feature_names=list(df.columns.drop(target_col)), target_name=target_col, filename=path, ) From 022d7480bd8c04852d462fbe10e206f0f108fc09 Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Wed, 17 Sep 2025 14:06:10 +0530 Subject: [PATCH 133/145] Update _base.py --- pyaptamer/benchmarking/_base.py | 144 +++++++++++++++----------------- 1 file changed, 69 insertions(+), 75 deletions(-) diff --git a/pyaptamer/benchmarking/_base.py b/pyaptamer/benchmarking/_base.py index bd6dcc6e..ccd62929 100644 --- a/pyaptamer/benchmarking/_base.py +++ b/pyaptamer/benchmarking/_base.py @@ -6,7 +6,7 @@ import numpy as np import pandas as pd from skbase.base import BaseObject -from sklearn.model_selection import check_cv, train_test_split +from sklearn.model_selection import cross_validate, train_test_split from pyaptamer.utils.tag_checks import task_check @@ -17,10 +17,10 @@ class Benchmarking(BaseObject): You can either: - - pass `X, y` (feature matrix and labels/targets) and let this class - split into train/test for you (if cv=None); or - - pass explicit `train_X, train_y, test_X, test_y` (if cv=None); or - - pass `X, y` along with `cv` to use cross-validation. + - pass `X, y` (feature matrix and labels/targets) and let this class + split into train/test automatically (if `cv=None`); or + - pass explicit `train_X, train_y, test_X, test_y` (if `cv=None`); or + - pass `X, y` along with `cv` to use cross-validation. Parameters ---------- @@ -108,39 +108,49 @@ def __init__( self.random_state = random_state self.cv = cv - if self.cv is None: - if X is not None and y is not None: - ( - self.train_X, - self.test_X, - self.train_y, - self.test_y, - ) = train_test_split( - X, - y, - test_size=self.test_size, - random_state=self.random_state, - stratify=y if self.stratify else None, - shuffle=True, - ) - elif ( - train_X is not None - and train_y is not None - and test_X is not None - and test_y is not None - ): - self.train_X, self.train_y = train_X, train_y - self.test_X, self.test_y = test_X, test_y - else: + # case 1: explicit train/test provided + if ( + train_X is not None + and train_y is not None + and test_X is not None + and test_y is not None + ): + if self.cv is not None: raise ValueError( - "Provide either (X, y) or (train_X, train_y, test_X, test_y)" - "when cv=None." + "Cannot use both explicit train/test splits and cross-validation. " + "Either provide (train_X, train_y, test_X, test_y) or (X, y, cv)." ) - else: + self.train_X, self.train_y = train_X, train_y + self.test_X, self.test_y = test_X, test_y + + # case 2: (X, y) with cv + elif self.cv is not None: if X is None or y is None: raise ValueError("Provide (X, y) when using cross-validation.") self.X, self.y = X, y + # case 3: (X, y) with hold-out split + elif X is not None and y is not None: + ( + self.train_X, + self.test_X, + self.train_y, + self.test_y, + ) = train_test_split( + X, + y, + test_size=self.test_size, + random_state=self.random_state, + stratify=y if self.stratify else None, + shuffle=True, + ) + + else: + raise ValueError( + "Provide either (X, y), (X, y, cv), or" + "(train_X, train_y, test_X, test_y)." + ) + self.results = None def _to_df(self, results): @@ -167,56 +177,41 @@ def run(self): cols = ["train", "test"]. """ task_check(self) - results = {} - if self.cv is not None: - # Cross-validation mode - cv = check_cv(self.cv, y=self.y, classifier=None) - + if hasattr(self, "X") and hasattr(self, "y"): for estimator in self.estimators: est_name = estimator.__class__.__name__ - metric_scores = { - metric.__name__: {"train": [], "test": []} - for metric in self.evaluators + + scoring = { + getattr( + evaluator, + "__name__", + getattr(evaluator, "name", evaluator.__class__.__name__), + ): evaluator + for evaluator in self.evaluators } - for train_idx, test_idx in cv.split(self.X, self.y): - X_train, X_test = self.X[train_idx], self.X[test_idx] - y_train, y_test = self.y[train_idx], self.y[test_idx] - - model = copy.deepcopy(estimator) - model.fit(X_train, y_train) - - # evaluate on both train and test fold parts - for split_name, (X_split, y_split) in { - "train": (X_train, y_train), - "test": (X_test, y_test), - }.items(): - y_pred = model.predict(X_split) - for evaluator in self.evaluators: - eval_name = getattr( - evaluator, - "__name__", - getattr( - evaluator, "name", evaluator.__class__.__name__ - ), - ) - metric_scores[eval_name][split_name].append( - evaluator(y_split, y_pred) - ) + cv_results = cross_validate( + estimator, + self.X, + self.y, + cv=self.cv, + scoring=scoring, + return_train_score=True, + ) # average across folds - results[est_name] = { - metric: { - "train": float(np.mean(scores["train"])), - "test": float(np.mean(scores["test"])), + est_scores = {} + for metric in scoring.keys(): + est_scores[metric] = { + "train": float(np.mean(cv_results[f"train_{metric}"])), + "test": float(np.mean(cv_results[f"test_{metric}"])), } - for metric, scores in metric_scores.items() - } + + results[est_name] = est_scores else: - # Hold-out mode for estimator in self.estimators: est_name = estimator.__class__.__name__ model = copy.deepcopy(estimator) @@ -228,16 +223,15 @@ def run(self): "test": (self.test_X, self.test_y), }.items(): y_pred = model.predict(X_split) - scores = {} for evaluator in self.evaluators: eval_name = getattr( evaluator, "__name__", getattr(evaluator, "name", evaluator.__class__.__name__), ) - scores[eval_name] = evaluator(y_split, y_pred) - for eval_name, score in scores.items(): - est_scores.setdefault(eval_name, {})[split_name] = score + est_scores.setdefault(eval_name, {})[split_name] = evaluator( + y_split, y_pred + ) results[est_name] = est_scores From 63ddaf6f077f083fb8e39a7d9294d6e9e5c385b4 Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Wed, 17 Sep 2025 14:09:42 +0530 Subject: [PATCH 134/145] Update test_csv_loader.py --- pyaptamer/datasets/tests/test_csv_loader.py | 8 ++++---- 1 file changed, 4 insertions(+), 4 deletions(-) diff --git a/pyaptamer/datasets/tests/test_csv_loader.py b/pyaptamer/datasets/tests/test_csv_loader.py index 6648cacf..ac06b8f9 100644 --- a/pyaptamer/datasets/tests/test_csv_loader.py +++ b/pyaptamer/datasets/tests/test_csv_loader.py @@ -11,9 +11,9 @@ def test_load_csv_return_x_y(): """ - When return_x_y=True the loader should return two numpy arrays (X, y). + When return_X_y=True the loader should return two numpy arrays (X, y). """ - X, y = load_csv_dataset(DATASET_NAME, target_col=TARGET_COL, return_x_y=True) + X, y = load_csv_dataset(DATASET_NAME, target_col=TARGET_COL, return_X_y=True) assert isinstance(X, np.ndarray), "X should be a numpy array" assert isinstance(y, np.ndarray), "y should be a numpy array" @@ -23,10 +23,10 @@ def test_load_csv_return_x_y(): def test_load_csv_returns_bunch(): """ - When return_x_y=False the loader should return a sklearn.utils.Bunch-like object + When return_X_y=False the loader should return a sklearn.utils.Bunch-like object containing data, target and frame. """ - bunch = load_csv_dataset(DATASET_NAME, target_col=TARGET_COL, return_x_y=False) + bunch = load_csv_dataset(DATASET_NAME, target_col=TARGET_COL, return_X_y=False) assert isinstance(bunch, Bunch), "Returned object should be a sklearn.utils.Bunch" assert bunch.data.shape[0] == len(bunch.frame), ( From 2c0608484ebc8cd98c381ae21f92611eec840f72 Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Sun, 21 Sep 2025 15:53:08 +0530 Subject: [PATCH 135/145] Update _base.py --- pyaptamer/benchmarking/_base.py | 12 ++++++------ 1 file changed, 6 insertions(+), 6 deletions(-) diff --git a/pyaptamer/benchmarking/_base.py b/pyaptamer/benchmarking/_base.py index ccd62929..b1b04b7f 100644 --- a/pyaptamer/benchmarking/_base.py +++ b/pyaptamer/benchmarking/_base.py @@ -26,7 +26,7 @@ class Benchmarking(BaseObject): ---------- estimators : list[estimator] | estimator List of sklearn-like estimators implementing `fit` and `predict`. - evaluators : list[callable] | callable + metrics : list[callable] | callable List of callables with signature ``(y_true, y_pred) -> float``. X : array-like, optional Feature matrix. Used together with `y` if explicit train/test splits @@ -77,7 +77,7 @@ class Benchmarking(BaseObject): >>> clf = AptaNetPipeline() >>> bench = Benchmarking( ... estimators=[clf], - ... evaluators=[accuracy_score], + ... metrics=[accuracy_score], ... X=X, ... y=y, ... ) @@ -89,7 +89,7 @@ class Benchmarking(BaseObject): def __init__( self, estimators, - evaluators, + metrics, X=None, y=None, train_X=None, @@ -102,7 +102,7 @@ def __init__( cv=None, ): self.estimators = estimators if isinstance(estimators, list) else [estimators] - self.evaluators = evaluators if isinstance(evaluators, list) else [evaluators] + self.metrics = metrics if isinstance(metrics, list) else [metrics] self.test_size = test_size self.stratify = stratify self.random_state = random_state @@ -189,7 +189,7 @@ def run(self): "__name__", getattr(evaluator, "name", evaluator.__class__.__name__), ): evaluator - for evaluator in self.evaluators + for evaluator in self.metrics } cv_results = cross_validate( @@ -223,7 +223,7 @@ def run(self): "test": (self.test_X, self.test_y), }.items(): y_pred = model.predict(X_split) - for evaluator in self.evaluators: + for evaluator in self.metrics: eval_name = getattr( evaluator, "__name__", From 7027d47fa59fbf6e02e3a2f3b88a350073f31b71 Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Sun, 21 Sep 2025 16:16:08 +0530 Subject: [PATCH 136/145] Update _base.py --- pyaptamer/benchmarking/_base.py | 9 ++++++--- 1 file changed, 6 insertions(+), 3 deletions(-) diff --git a/pyaptamer/benchmarking/_base.py b/pyaptamer/benchmarking/_base.py index b1b04b7f..ac0cfd59 100644 --- a/pyaptamer/benchmarking/_base.py +++ b/pyaptamer/benchmarking/_base.py @@ -8,8 +8,6 @@ from skbase.base import BaseObject from sklearn.model_selection import cross_validate, train_test_split -from pyaptamer.utils.tag_checks import task_check - class Benchmarking(BaseObject): """ @@ -175,8 +173,13 @@ def run(self): pd.DataFrame Results table with rows = (estimator, metric), cols = ["train", "test"]. + + Example + ------- + train test + estimator metric + AptaNetPipeline accuracy_score 1.0 1.0 """ - task_check(self) results = {} if hasattr(self, "X") and hasattr(self, "y"): From ec96bbaded938cd842fc6e3e7c8bfb653fb5e1f5 Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Sun, 21 Sep 2025 17:42:58 +0530 Subject: [PATCH 137/145] cleaning code remove tag checks --- pyaptamer/benchmarking/_base.py | 218 ++++++++------------------------ pyaptamer/utils/tag_checks.py | 27 ---- 2 files changed, 55 insertions(+), 190 deletions(-) delete mode 100644 pyaptamer/utils/tag_checks.py diff --git a/pyaptamer/benchmarking/_base.py b/pyaptamer/benchmarking/_base.py index ac0cfd59..d69e6dad 100644 --- a/pyaptamer/benchmarking/_base.py +++ b/pyaptamer/benchmarking/_base.py @@ -1,56 +1,38 @@ __author__ = "satvshr" __all__ = ["Benchmarking"] -import copy import numpy as np import pandas as pd from skbase.base import BaseObject -from sklearn.model_selection import cross_validate, train_test_split +from sklearn.model_selection import cross_validate class Benchmarking(BaseObject): """ - Benchmark estimators on train/test splits or cross-validation. + Benchmark estimators using cross-validation. - You can either: + You can: - - pass `X, y` (feature matrix and labels/targets) and let this class - split into train/test automatically (if `cv=None`); or - - pass explicit `train_X, train_y, test_X, test_y` (if `cv=None`); or - - pass `X, y` along with `cv` to use cross-validation. + - pass `X, y` (feature matrix and labels/targets) along with `cv` + to use any cross-validation strategy; + - if you want a fixed train/test split, pass a `PredefinedSplit` + object as `cv`. Parameters ---------- estimators : list[estimator] | estimator List of sklearn-like estimators implementing `fit` and `predict`. metrics : list[callable] | callable - List of callables with signature ``(y_true, y_pred) -> float``. - X : array-like, optional - Feature matrix. Used together with `y` if explicit train/test splits - are not provided. - y : array-like, optional - Target vector. Used together with `X` if explicit train/test splits - are not provided. - train_X : array-like, optional - Training feature matrix (ignored if `cv` is given). - train_y : array-like, optional - Training labels/targets (ignored if `cv` is given). - test_X : array-like, optional - Test feature matrix (ignored if `cv` is given). - test_y : array-like, optional - Test labels/targets (ignored if `cv` is given). - test_size : float, default=0.2 - Fraction of data to reserve for the test split when splitting `X, y`. - Ignored if `cv` is provided. - stratify : bool, default=True - If True, and the task is classification, stratify the train/test split - using `y`. Ignored if `cv` is provided. - random_state : int or None, default=42 - Random state for reproducibility in splits. + List of callables with signature `(y_true, y_pred) -> float`. + X : array-like + Feature matrix. + y : array-like + Target vector. cv : int, CV splitter, or None, default=None - Cross-validation strategy. If provided, results are averaged - across folds and returned in the same format as hold-out mode. + Cross-validation strategy. If `None`, defaults to 5-fold CV. + If you want to use an explicit train/test split, pass a + `PredefinedSplit` object. Attributes ---------- @@ -62,93 +44,34 @@ class Benchmarking(BaseObject): Example ------- - >>> import pandas as pd >>> import numpy as np >>> from sklearn.metrics import accuracy_score + >>> from sklearn.model_selection import PredefinedSplit >>> from pyaptamer.benchmarking._base import Benchmarking >>> from pyaptamer.aptanet import AptaNetPipeline - >>> from pyaptamer.datasets import load_csv_dataset - >>> X, y = load_csv_dataset("train_li2014", "label", return_X_y=True) - >>> X = X[:10] # smaller example - >>> y = y[:10] - >>> y = np.where(y == "positive", 1, 0) + >>> X = np.random.randn(10, 5) + >>> y = np.random.randint(0, 2, size=10) >>> clf = AptaNetPipeline() + >>> # define a fixed train/test split + >>> test_fold = np.ones(len(y)) * -1 + >>> test_fold[-2:] = 0 + >>> cv = PredefinedSplit(test_fold) >>> bench = Benchmarking( ... estimators=[clf], ... metrics=[accuracy_score], ... X=X, ... y=y, + ... cv=cv, ... ) >>> summary = bench.run() # doctest: +SKIP """ - _tags = {"tasks": ["classification", "regression"]} - - def __init__( - self, - estimators, - metrics, - X=None, - y=None, - train_X=None, - train_y=None, - test_X=None, - test_y=None, - test_size=0.2, - stratify=True, - random_state=None, - cv=None, - ): + def __init__(self, estimators, metrics, X, y, cv=None): self.estimators = estimators if isinstance(estimators, list) else [estimators] self.metrics = metrics if isinstance(metrics, list) else [metrics] - self.test_size = test_size - self.stratify = stratify - self.random_state = random_state + self.X = X + self.y = y self.cv = cv - - # case 1: explicit train/test provided - if ( - train_X is not None - and train_y is not None - and test_X is not None - and test_y is not None - ): - if self.cv is not None: - raise ValueError( - "Cannot use both explicit train/test splits and cross-validation. " - "Either provide (train_X, train_y, test_X, test_y) or (X, y, cv)." - ) - self.train_X, self.train_y = train_X, train_y - self.test_X, self.test_y = test_X, test_y - - # case 2: (X, y) with cv - elif self.cv is not None: - if X is None or y is None: - raise ValueError("Provide (X, y) when using cross-validation.") - self.X, self.y = X, y - - # case 3: (X, y) with hold-out split - elif X is not None and y is not None: - ( - self.train_X, - self.test_X, - self.train_y, - self.test_y, - ) = train_test_split( - X, - y, - test_size=self.test_size, - random_state=self.random_state, - stratify=y if self.stratify else None, - shuffle=True, - ) - - else: - raise ValueError( - "Provide either (X, y), (X, y, cv), or" - "(train_X, train_y, test_X, test_y)." - ) - self.results = None def _to_df(self, results): @@ -166,77 +89,46 @@ def _to_df(self, results): def run(self): """ - Train each estimator and evaluate with hold-out or cross-validation. + Train each estimator and evaluate with cross-validation. Returns ------- pd.DataFrame Results table with rows = (estimator, metric), cols = ["train", "test"]. - - Example - ------- - train test - estimator metric - AptaNetPipeline accuracy_score 1.0 1.0 """ results = {} - if hasattr(self, "X") and hasattr(self, "y"): - for estimator in self.estimators: - est_name = estimator.__class__.__name__ - - scoring = { - getattr( - evaluator, - "__name__", - getattr(evaluator, "name", evaluator.__class__.__name__), - ): evaluator - for evaluator in self.metrics + for estimator in self.estimators: + est_name = estimator.__class__.__name__ + + scoring = { + getattr( + evaluator, + "__name__", + getattr(evaluator, "name", evaluator.__class__.__name__), + ): evaluator + for evaluator in self.metrics + } + + cv_results = cross_validate( + estimator, + self.X, + self.y, + cv=self.cv, + scoring=scoring, + return_train_score=True, + ) + + # average across folds + est_scores = {} + for metric in scoring.keys(): + est_scores[metric] = { + "train": float(np.mean(cv_results[f"train_{metric}"])), + "test": float(np.mean(cv_results[f"test_{metric}"])), } - cv_results = cross_validate( - estimator, - self.X, - self.y, - cv=self.cv, - scoring=scoring, - return_train_score=True, - ) - - # average across folds - est_scores = {} - for metric in scoring.keys(): - est_scores[metric] = { - "train": float(np.mean(cv_results[f"train_{metric}"])), - "test": float(np.mean(cv_results[f"test_{metric}"])), - } - - results[est_name] = est_scores - - else: - for estimator in self.estimators: - est_name = estimator.__class__.__name__ - model = copy.deepcopy(estimator) - model.fit(self.train_X, self.train_y) - - est_scores = {} - for split_name, (X_split, y_split) in { - "train": (self.train_X, self.train_y), - "test": (self.test_X, self.test_y), - }.items(): - y_pred = model.predict(X_split) - for evaluator in self.metrics: - eval_name = getattr( - evaluator, - "__name__", - getattr(evaluator, "name", evaluator.__class__.__name__), - ) - est_scores.setdefault(eval_name, {})[split_name] = evaluator( - y_split, y_pred - ) - - results[est_name] = est_scores + results[est_name] = est_scores self.results = self._to_df(results) return self.results diff --git a/pyaptamer/utils/tag_checks.py b/pyaptamer/utils/tag_checks.py deleted file mode 100644 index cc0c1065..00000000 --- a/pyaptamer/utils/tag_checks.py +++ /dev/null @@ -1,27 +0,0 @@ -__author__ = "satvshr" -__all__ = ["task_check"] - -"""Add all `_tag` checking functions here.""" - - -def task_check(estimator): - """ - Validate that an estimator's `task` is declared in its scikit-learn tags. - - Parameters - ---------- - estimator : object - An estimator object that implements `get_tags()` and exposes a - `.task` attribute indicating the intended task (e.g., "classification", - "regression"). - - Raises - ------ - ValueError - If `estimator.task` is not contained in the estimator's `"tasks"` tag. - """ - tags = estimator.get_tags() - if estimator.task not in tags["tasks"]: - raise ValueError( - f"Invalid task '{estimator.task}'. Must be one of {tags['tasks']}." - ) From d6111a9f43e5e42dbdb49b484dafaec28632e678 Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Sun, 21 Sep 2025 17:53:28 +0530 Subject: [PATCH 138/145] Update _base.py --- pyaptamer/benchmarking/_base.py | 6 ++++++ 1 file changed, 6 insertions(+) diff --git a/pyaptamer/benchmarking/_base.py b/pyaptamer/benchmarking/_base.py index d69e6dad..76520f90 100644 --- a/pyaptamer/benchmarking/_base.py +++ b/pyaptamer/benchmarking/_base.py @@ -96,6 +96,12 @@ def run(self): pd.DataFrame Results table with rows = (estimator, metric), cols = ["train", "test"]. + + Example + ------- + train test + estimator metric + AptaNetPipeline accuracy_score 1.0 1.0 """ results = {} From 2e2d71ffd6edd7bf9865bede13b92fbeb40f61b8 Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Sun, 21 Sep 2025 18:58:16 +0530 Subject: [PATCH 139/145] Test suite added and bugs fixed --- pyaptamer/aptanet/_pipeline.py | 15 ++-- pyaptamer/benchmarking/_base.py | 39 +++++----- pyaptamer/benchmarking/tests/__init__.py | 1 + .../benchmarking/tests/test_benchmarking.py | 78 +++++++++++++++++++ 4 files changed, 106 insertions(+), 27 deletions(-) create mode 100644 pyaptamer/benchmarking/tests/__init__.py create mode 100644 pyaptamer/benchmarking/tests/test_benchmarking.py diff --git a/pyaptamer/aptanet/_pipeline.py b/pyaptamer/aptanet/_pipeline.py index f73dcba3..3c309f92 100644 --- a/pyaptamer/aptanet/_pipeline.py +++ b/pyaptamer/aptanet/_pipeline.py @@ -2,6 +2,7 @@ __all__ = ["AptaNetPipeline"] __required__ = ["python>=3.9,<3.13"] +from skbase.base import BaseObject from sklearn.base import clone from sklearn.pipeline import Pipeline from sklearn.preprocessing import FunctionTransformer @@ -11,7 +12,7 @@ from pyaptamer.utils._aptanet_utils import pairs_to_features -class AptaNetPipeline: +class AptaNetPipeline(BaseObject): """ AptaNet algorithm for aptamer–protein interaction prediction [1]_ @@ -22,14 +23,14 @@ class AptaNetPipeline: The pipeline starts from string pairs, converts them into numeric features (aptamer k-mer frequencies + protein PSeAAC), applies tree-based feature - selection, and feeds the result into the classifier. + selection, and feeds the result into the estimator. Parameters ---------- k : int, optional, default=4 The k-mer size used to generate aptamer k-mer vectors. - classifier : sklearn-compatible estimator or None, default=None + estimator : sklearn-compatible estimator or None, default=None Estimator applied after feature selection. If None, uses `AptaNetClassifier`. Attributes @@ -61,9 +62,9 @@ class AptaNetPipeline: >>> preds = pipe.predict(X_test_pairs) """ - def __init__(self, k=4, classifier=None): + def __init__(self, k=4, estimator=None): self.k = k - self.classifier = classifier + self.estimator = estimator def _build_pipeline(self): transformer = FunctionTransformer( @@ -71,8 +72,8 @@ def _build_pipeline(self): kw_args={"k": self.k}, validate=False, ) - self._classifier = self.classifier or AptaNetClassifier() - return Pipeline([("features", transformer), ("clf", clone(self._classifier))]) + self._estimator = self.estimator or AptaNetClassifier() + return Pipeline([("features", transformer), ("clf", clone(self._estimator))]) def fit(self, X, y): self.pipeline_ = self._build_pipeline() diff --git a/pyaptamer/benchmarking/_base.py b/pyaptamer/benchmarking/_base.py index 76520f90..4cdaf048 100644 --- a/pyaptamer/benchmarking/_base.py +++ b/pyaptamer/benchmarking/_base.py @@ -1,14 +1,13 @@ __author__ = "satvshr" __all__ = ["Benchmarking"] - import numpy as np import pandas as pd -from skbase.base import BaseObject +from sklearn.metrics import make_scorer from sklearn.model_selection import cross_validate -class Benchmarking(BaseObject): +class Benchmarking: """ Benchmark estimators using cross-validation. @@ -74,6 +73,20 @@ def __init__(self, estimators, metrics, X, y, cv=None): self.cv = cv self.results = None + def _to_scorers(self, metrics): + """Convert metric callables to a dict of scorers.""" + scorers = {} + for metric in metrics: + if not callable(metric): + raise ValueError("Each metric should be a callable.") + name = ( + metric.__name__ + if hasattr(metric, "__name__") + else metric.__class__.__name__ + ) + scorers[name] = make_scorer(metric) + return scorers + def _to_df(self, results): """Convert nested results to a unified DataFrame.""" records = [] @@ -96,39 +109,25 @@ def run(self): pd.DataFrame Results table with rows = (estimator, metric), cols = ["train", "test"]. - - Example - ------- - train test - estimator metric - AptaNetPipeline accuracy_score 1.0 1.0 """ + self.scorers_ = self._to_scorers(self.metrics) results = {} for estimator in self.estimators: est_name = estimator.__class__.__name__ - scoring = { - getattr( - evaluator, - "__name__", - getattr(evaluator, "name", evaluator.__class__.__name__), - ): evaluator - for evaluator in self.metrics - } - cv_results = cross_validate( estimator, self.X, self.y, cv=self.cv, - scoring=scoring, + scoring=self.scorers_, return_train_score=True, ) # average across folds est_scores = {} - for metric in scoring.keys(): + for metric in self.scorers_.keys(): est_scores[metric] = { "train": float(np.mean(cv_results[f"train_{metric}"])), "test": float(np.mean(cv_results[f"test_{metric}"])), diff --git a/pyaptamer/benchmarking/tests/__init__.py b/pyaptamer/benchmarking/tests/__init__.py new file mode 100644 index 00000000..cf40889b --- /dev/null +++ b/pyaptamer/benchmarking/tests/__init__.py @@ -0,0 +1 @@ +"""Test suite for the benchmarking module""" diff --git a/pyaptamer/benchmarking/tests/test_benchmarking.py b/pyaptamer/benchmarking/tests/test_benchmarking.py new file mode 100644 index 00000000..4a9508e2 --- /dev/null +++ b/pyaptamer/benchmarking/tests/test_benchmarking.py @@ -0,0 +1,78 @@ +import sys + +import numpy as np +import pytest +from sklearn.metrics import accuracy_score, mean_squared_error +from sklearn.model_selection import PredefinedSplit + +from pyaptamer.aptanet import AptaNetPipeline, AptaNetRegressor +from pyaptamer.benchmarking._base import Benchmarking + +params = [ + ( + "AGCTTAGCGTACAGCTTAAAAGGGTTTCCCCTGCCCGCGTAC", + "ACDEFGHIKLMNPQRSTVWYACDEFGHIKLMNPQRSTVWY", + ) +] + + +@pytest.mark.skipif( + sys.version_info >= (3, 13), reason="skorch does not support Python 3.13" +) +@pytest.mark.parametrize("aptamer_seq, protein_seq", params) +def test_benchmarking_with_predefined_split_classification(aptamer_seq, protein_seq): + """ + Test Benchmarking on a classification task using PredefinedSplit. + """ + X_raw = [(aptamer_seq, protein_seq) for _ in range(40)] + y = np.array([0] * 20 + [1] * 20, dtype=np.float32) + + clf = AptaNetPipeline() + + test_fold = np.ones(len(y), dtype=int) * -1 + test_fold[-2:] = 0 + cv = PredefinedSplit(test_fold) + + bench = Benchmarking( + estimators=[clf], + metrics=[accuracy_score], + X=X_raw, + y=y, + cv=cv, + ) + summary = bench.run() + + assert "train" in summary.columns + assert "test" in summary.columns + assert (clf.__class__.__name__, "accuracy_score") in summary.index + + +@pytest.mark.skipif( + sys.version_info >= (3, 13), reason="skorch does not support Python 3.13" +) +@pytest.mark.parametrize("aptamer_seq, protein_seq", params) +def test_benchmarking_with_predefined_split_regression(aptamer_seq, protein_seq): + """ + Test Benchmarking on a regression task using PredefinedSplit. + """ + X_raw = [(aptamer_seq, protein_seq) for _ in range(40)] + y = np.linspace(0, 1, 40).astype(np.float32) + + reg = AptaNetPipeline(estimator=AptaNetRegressor()) + + test_fold = np.ones(len(y), dtype=int) * -1 + test_fold[-3:] = 0 + cv = PredefinedSplit(test_fold) + + bench = Benchmarking( + estimators=[reg], + metrics=[mean_squared_error], + X=X_raw, + y=y, + cv=cv, + ) + summary = bench.run() + + assert "train" in summary.columns + assert "test" in summary.columns + assert (reg.__class__.__name__, "mean_squared_error") in summary.index From 90af1ee26562d658a84f88cda31c8ed0a6cd014e Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Sun, 21 Sep 2025 19:12:23 +0530 Subject: [PATCH 140/145] arg name fixing --- examples/aptanet_tutorial.ipynb | 2 +- pyaptamer/aptanet/tests/test_aptanet.py | 2 +- 2 files changed, 2 insertions(+), 2 deletions(-) diff --git a/examples/aptanet_tutorial.ipynb b/examples/aptanet_tutorial.ipynb index d89d41ec..a9f66b27 100644 --- a/examples/aptanet_tutorial.ipynb +++ b/examples/aptanet_tutorial.ipynb @@ -554,7 +554,7 @@ " ]\n", ")\n", "\n", - "pipeline = AptaNetPipeline(classifier=model)" + "pipeline = AptaNetPipeline(estimator=model)" ] }, { diff --git a/pyaptamer/aptanet/tests/test_aptanet.py b/pyaptamer/aptanet/tests/test_aptanet.py index 1206c18d..54ea2cc7 100644 --- a/pyaptamer/aptanet/tests/test_aptanet.py +++ b/pyaptamer/aptanet/tests/test_aptanet.py @@ -46,7 +46,7 @@ def test_pipeline_fit_and_predict_regression(aptamer_seq, protein_seq): Test if Pipeline predictions are valid floats and shape matches input for regression. """ - pipe = AptaNetPipeline(classifier=AptaNetRegressor()) + pipe = AptaNetPipeline(estimator=AptaNetRegressor()) X_raw = [(aptamer_seq, protein_seq) for _ in range(40)] y = np.linspace(0, 1, 40).astype(np.float32) From 971ae2963c3ae4238108f62f36f893b6046c0894 Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Mon, 22 Sep 2025 16:09:24 +0530 Subject: [PATCH 141/145] Update _csv_loader.py --- pyaptamer/datasets/_loaders/_csv_loader.py | 43 +++++++--------------- 1 file changed, 13 insertions(+), 30 deletions(-) diff --git a/pyaptamer/datasets/_loaders/_csv_loader.py b/pyaptamer/datasets/_loaders/_csv_loader.py index 9c8cc58b..caf21e35 100644 --- a/pyaptamer/datasets/_loaders/_csv_loader.py +++ b/pyaptamer/datasets/_loaders/_csv_loader.py @@ -4,12 +4,11 @@ import os import pandas as pd -from sklearn.utils import Bunch def load_csv_dataset(name, target_col, return_X_y=False): """ - Load a dataset from a CSV file in a sklearn-like format. + Load a dataset from a CSV file in DataFrame format. Parameters ---------- @@ -19,23 +18,16 @@ def load_csv_dataset(name, target_col, return_X_y=False): target_col : str Column name in the CSV to use as the target variable. return_X_y : bool, optional, default=False - If True, return (X, y) as NumPy arrays. If False, return a sklearn.utils.Bunch - with attributes similar to sklearn dataset loaders. + If True, return (X_df, y_df) as pandas DataFrames. + If False, return the full DataFrame (features + target). Returns ------- - sklearn.utils.Bunch or tuple of np.ndarray - If `return_X_y` is False, returns a Bunch with fields: - - data: ndarray of shape (n_samples, n_features) - - target: ndarray of shape (n_samples,) - - frame: pandas.DataFrame (the loaded DataFrame) - - feature_names: list[str] (column names used as features) - - target_name: str (the name of the target column) - - filename: str (resolved path to the CSV file) - If `return_X_y` is True, returns (X, y) where: - - X : ndarray of shape (n_samples, n_features) built by dropping the target - column - - y : ndarray of shape (n_samples,) from the target column + pandas.DataFrame or tuple of pandas.DataFrame + If `return_X_y` is False, returns the full DataFrame with all columns. + If `return_X_y` is True, returns: + - X_df : pd.DataFrame of shape (n_samples, n_features) + - y_df : pd.DataFrame of shape (n_samples, 1) """ path = os.path.relpath( os.path.join(os.path.dirname(__file__), "..", "data", f"{name}.csv") @@ -43,18 +35,9 @@ def load_csv_dataset(name, target_col, return_X_y=False): df = pd.read_csv(path) - X = df.drop(columns=[target_col]).to_numpy() - y = df[target_col].to_numpy() - if return_X_y: - return X, y - - bunch = Bunch( - data=X, - target=y, - frame=df, - feature_names=list(df.columns.drop(target_col)), - target_name=target_col, - filename=path, - ) - return bunch + X_df = df.drop(columns=[target_col]) + y_df = df[[target_col]] + return X_df, y_df + + return df From fe19150ae9d6c83b30de730b7b97c634b7d50bfc Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Mon, 22 Sep 2025 16:25:15 +0530 Subject: [PATCH 142/145] Update test_csv_loader.py --- pyaptamer/datasets/tests/test_csv_loader.py | 34 +++++++++++---------- 1 file changed, 18 insertions(+), 16 deletions(-) diff --git a/pyaptamer/datasets/tests/test_csv_loader.py b/pyaptamer/datasets/tests/test_csv_loader.py index ac06b8f9..e39d0fd3 100644 --- a/pyaptamer/datasets/tests/test_csv_loader.py +++ b/pyaptamer/datasets/tests/test_csv_loader.py @@ -1,7 +1,6 @@ __author__ = "satvshr" -import numpy as np -from sklearn.utils import Bunch +import pandas as pd from pyaptamer.datasets._loaders._csv_loader import load_csv_dataset @@ -11,25 +10,28 @@ def test_load_csv_return_x_y(): """ - When return_X_y=True the loader should return two numpy arrays (X, y). + When return_X_y=True the loader should return two pandas objects (X_df, y_df). """ - X, y = load_csv_dataset(DATASET_NAME, target_col=TARGET_COL, return_X_y=True) + X_df, y_df = load_csv_dataset(DATASET_NAME, target_col=TARGET_COL, return_X_y=True) - assert isinstance(X, np.ndarray), "X should be a numpy array" - assert isinstance(y, np.ndarray), "y should be a numpy array" - assert X.shape[0] == y.shape[0], "Number of samples in X and y must match" - assert X.ndim == 2, "X should be a 2D array (n_samples, n_features)" + assert isinstance(X_df, pd.DataFrame), "X should be a pandas DataFrame" + assert isinstance(y_df, pd.DataFrame), ( + "y should be a pandas DataFrame (single-column)" + ) + assert X_df.shape[0] == y_df.shape[0], "Number of samples in X and y must match" + assert X_df.ndim == 2, "X should be a 2D DataFrame (n_samples, n_features)" + assert y_df.shape[1] == 1, "y should have a single column" -def test_load_csv_returns_bunch(): +def test_load_csv_returns_df(): """ - When return_X_y=False the loader should return a sklearn.utils.Bunch-like object - containing data, target and frame. + When return_X_y=False the loader should return the full DataFrame containing the + target column. """ - bunch = load_csv_dataset(DATASET_NAME, target_col=TARGET_COL, return_X_y=False) + df = load_csv_dataset(DATASET_NAME, target_col=TARGET_COL, return_X_y=False) - assert isinstance(bunch, Bunch), "Returned object should be a sklearn.utils.Bunch" - assert bunch.data.shape[0] == len(bunch.frame), ( - "data length must match number of rows in frame" + assert isinstance(df, pd.DataFrame), "Returned object should be a pandas DataFrame" + assert TARGET_COL in df.columns, ( + f"DataFrame must contain the target column '{TARGET_COL}'" ) - assert bunch.target_name == TARGET_COL + assert df.shape[0] > 0, "DataFrame should not be empty" From 18833f095985d7564884ceb51611e8d0880f5348 Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Tue, 30 Sep 2025 02:09:23 +0530 Subject: [PATCH 143/145] fixed docstring and example --- pyaptamer/benchmarking/_base.py | 33 ++++++++++++++++++++++++--------- 1 file changed, 24 insertions(+), 9 deletions(-) diff --git a/pyaptamer/benchmarking/_base.py b/pyaptamer/benchmarking/_base.py index 4cdaf048..7fc1bdca 100644 --- a/pyaptamer/benchmarking/_base.py +++ b/pyaptamer/benchmarking/_base.py @@ -36,10 +36,15 @@ class Benchmarking: Attributes ---------- results : pd.DataFrame - Results table after calling :meth:`run`. + DataFrame produced by :meth:`run`. - - Rows = MultiIndex (estimator, metric) - - Cols = ["train", "test"] + - Index: pandas.MultiIndex with two levels (names shown in parentheses) + - level 0 "estimator": estimator name + - level 1 "metric": evaluator name + - Columns: ["train", "test"] (both floats) + - Cell values: mean scores (float) computed across CV folds: + - "train" = mean of cross_validate(...)[f"train_{metric}"] + - "test" = mean of cross_validate(...)[f"test_{metric}"] Example ------- @@ -48,9 +53,12 @@ class Benchmarking: >>> from sklearn.model_selection import PredefinedSplit >>> from pyaptamer.benchmarking._base import Benchmarking >>> from pyaptamer.aptanet import AptaNetPipeline - >>> X = np.random.randn(10, 5) - >>> y = np.random.randint(0, 2, size=10) - >>> clf = AptaNetPipeline() + >>> aptamer_seq = "AGCTTAGCGTACAGCTTAAAAGGGTTTCCCCTGCCCGCGTAC" + >>> protein_seq = "ACDEFGHIKLMNPQRSTVWYACDEFGHIKLMNPQRSTVWY" + >>> # dataset: 20 aptamer–protein pairs + >>> X = [(aptamer_seq, protein_seq) for _ in range(20)] + >>> y = np.array([0] * 10 + [1] * 10, dtype=np.float32) + >>> clf = AptaNetPipeline(k=4) >>> # define a fixed train/test split >>> test_fold = np.ones(len(y)) * -1 >>> test_fold[-2:] = 0 @@ -106,9 +114,16 @@ def run(self): Returns ------- - pd.DataFrame - Results table with rows = (estimator, metric), - cols = ["train", "test"]. + results : pd.DataFrame + + - Index: pandas.MultiIndex with two levels (names shown in parentheses) + - level 0 "estimator": estimator name + - level 1 "metric": evaluator name + - Columns: ["train", "test"] (both floats) + - Cell values: mean scores (float) computed across CV folds: + - "train" = mean of cross_validate(...)[f"train_{metric}"] + - "test" = mean of cross_validate(...)[f"test_{metric}"] + """ self.scorers_ = self._to_scorers(self.metrics) results = {} From 84a2754b1c9e5af1baeca58f19ee15514ea26191 Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Tue, 30 Sep 2025 15:44:52 +0530 Subject: [PATCH 144/145] Update _aptanet_utils.py --- pyaptamer/utils/_aptanet_utils.py | 29 ----------------------------- 1 file changed, 29 deletions(-) diff --git a/pyaptamer/utils/_aptanet_utils.py b/pyaptamer/utils/_aptanet_utils.py index aa100b9e..dd2de07c 100644 --- a/pyaptamer/utils/_aptanet_utils.py +++ b/pyaptamer/utils/_aptanet_utils.py @@ -94,32 +94,3 @@ def pairs_to_features(X, k=4): # Ensure float32 for PyTorch compatibility return np.vstack(feats).astype(np.float32) - - -def rna2dna(seq): - """ - Convert an RNA sequence to a DNA sequence. - - Nucleotides 'U' in the RNA sequence are replaced with 'T' in the DNA sequence. - Unknown nucleotides are replaced with 'N'. Other nucleotides ('A', 'C', 'G') - remain unchanged. - - Parameters - ---------- - seq : str - The RNA sequence to be converted. - - Returns - ------- - str - The converted DNA sequence. - """ - # Replace nucleotides 'U' with 'T' - result = seq.translate(str.maketrans("U", "T")) - - # Replace any unknown characters with 'N' - for char in result: - if char not in "ACGT": - result = result.replace(char, "N") - - return result From f9cece01931c1f05213ae870aa4bf825943d3f0f Mon Sep 17 00:00:00 2001 From: Satvik Mishra <112589278+satvshr@users.noreply.github.com> Date: Tue, 14 Oct 2025 13:40:37 +0530 Subject: [PATCH 145/145] Delete test_csv_loader.py --- pyaptamer/datasets/tests/test_csv_loader.py | 37 --------------------- 1 file changed, 37 deletions(-) delete mode 100644 pyaptamer/datasets/tests/test_csv_loader.py diff --git a/pyaptamer/datasets/tests/test_csv_loader.py b/pyaptamer/datasets/tests/test_csv_loader.py deleted file mode 100644 index e39d0fd3..00000000 --- a/pyaptamer/datasets/tests/test_csv_loader.py +++ /dev/null @@ -1,37 +0,0 @@ -__author__ = "satvshr" - -import pandas as pd - -from pyaptamer.datasets._loaders._csv_loader import load_csv_dataset - -DATASET_NAME = "train_li2014" -TARGET_COL = "label" - - -def test_load_csv_return_x_y(): - """ - When return_X_y=True the loader should return two pandas objects (X_df, y_df). - """ - X_df, y_df = load_csv_dataset(DATASET_NAME, target_col=TARGET_COL, return_X_y=True) - - assert isinstance(X_df, pd.DataFrame), "X should be a pandas DataFrame" - assert isinstance(y_df, pd.DataFrame), ( - "y should be a pandas DataFrame (single-column)" - ) - assert X_df.shape[0] == y_df.shape[0], "Number of samples in X and y must match" - assert X_df.ndim == 2, "X should be a 2D DataFrame (n_samples, n_features)" - assert y_df.shape[1] == 1, "y should have a single column" - - -def test_load_csv_returns_df(): - """ - When return_X_y=False the loader should return the full DataFrame containing the - target column. - """ - df = load_csv_dataset(DATASET_NAME, target_col=TARGET_COL, return_X_y=False) - - assert isinstance(df, pd.DataFrame), "Returned object should be a pandas DataFrame" - assert TARGET_COL in df.columns, ( - f"DataFrame must contain the target column '{TARGET_COL}'" - ) - assert df.shape[0] > 0, "DataFrame should not be empty"