diff --git a/easybuild/easyblocks/generic/cmakemake.py b/easybuild/easyblocks/generic/cmakemake.py
index eb0d5820186..486092ba01d 100644
--- a/easybuild/easyblocks/generic/cmakemake.py
+++ b/easybuild/easyblocks/generic/cmakemake.py
@@ -302,6 +302,23 @@ def configure_step(self, srcdir=None, builddir=None):
                 options['BOOST_ROOT'] = boost_root
                 options['Boost_NO_SYSTEM_PATHS'] = 'ON'
 
+        # Make sure CMake finds our Python when it is a direct or indirect dependency
+        python_root = get_software_root('Python')
+        if python_root:
+            # CMake 3.12 introduced FindPython/FindPython2/FindPython3
+            # Below only FindPythonInterp existed in core CMake which don't has such hints.
+            # However PYTHON_EXECUTABLE could be used.
+            if LooseVersion(self.cmake_version) >= '3.12':
+                python_version = LooseVersion(get_software_version('Python'))
+                # For find_package(Python)
+                options['Python_ROOT_DIR'] = python_root
+                if python_version >= '3':
+                    # For find_package(Python3)
+                    options['Python3_ROOT_DIR'] = python_root
+                else:
+                    # For find_package(Python2)
+                    options['Python2_ROOT_DIR'] = python_root
+
         if self.cfg.get('configure_cmd') == DEFAULT_CONFIGURE_CMD:
             self.prepend_config_opts(options)
             command = ' '.join([