diff --git a/src/coreclr/clrdefinitions.cmake b/src/coreclr/clrdefinitions.cmake
index 3805833874132f..03615c9106bd02 100644
--- a/src/coreclr/clrdefinitions.cmake
+++ b/src/coreclr/clrdefinitions.cmake
@@ -132,9 +132,12 @@ if (CLR_CMAKE_TARGET_WIN32 AND (CLR_CMAKE_TARGET_ARCH_AMD64 OR CLR_CMAKE_TARGET_
     add_definitions(-DFEATURE_INTEROP_DEBUGGING)
 endif (CLR_CMAKE_TARGET_WIN32 AND (CLR_CMAKE_TARGET_ARCH_AMD64 OR CLR_CMAKE_TARGET_ARCH_I386 OR CLR_CMAKE_TARGET_ARCH_ARM64))
 if(FEATURE_INTERPRETER)
-  add_compile_definitions(FEATURE_INTERPRETER)
+    add_compile_definitions(FEATURE_INTERPRETER)
 endif(FEATURE_INTERPRETER)
-add_definitions(-DFEATURE_ISYM_READER)
+
+if (CLR_CMAKE_TARGET_WIN32)
+    add_definitions(-DFEATURE_ISYM_READER)
+endif(CLR_CMAKE_TARGET_WIN32)
 
 if(FEATURE_MERGE_JIT_AND_ENGINE)
   add_compile_definitions($<$<NOT:$<BOOL:$<TARGET_PROPERTY:IGNORE_FEATURE_MERGE_JIT_AND_ENGINE>>>:FEATURE_MERGE_JIT_AND_ENGINE>)