diff --git a/src/coreclr/nativeaot/CMakeLists.txt b/src/coreclr/nativeaot/CMakeLists.txt
index 91fa37cfad0907..74bf4449e24c7c 100644
--- a/src/coreclr/nativeaot/CMakeLists.txt
+++ b/src/coreclr/nativeaot/CMakeLists.txt
@@ -37,7 +37,7 @@ if(CLR_CMAKE_HOST_UNIX)
   endif(CLR_CMAKE_TARGET_ARCH_AMD64 OR CLR_CMAKE_TARGET_ARCH_I386)
 endif (CLR_CMAKE_HOST_UNIX)
 
-if(CLR_CMAKE_HOST_ALPINE_LINUX)
+if(CLR_CMAKE_TARGET_LINUX_MUSL)
     # Fix up the main thread stack size for MUSL to more reasonable size.
     # TODO: https://github.com/dotnet/runtimelab/issues/791
     add_definitions(-DENSURE_PRIMARY_STACK_SIZE)
diff --git a/src/native/libs/System.Native/CMakeLists.txt b/src/native/libs/System.Native/CMakeLists.txt
index 8580bcfaa2571c..2c6249cc516273 100644
--- a/src/native/libs/System.Native/CMakeLists.txt
+++ b/src/native/libs/System.Native/CMakeLists.txt
@@ -4,7 +4,7 @@ if (NOT CLR_CMAKE_TARGET_MACCATALYST AND NOT CLR_CMAKE_TARGET_IOS AND NOT CLR_CM
     add_definitions(-DHAS_CONSOLE_SIGNALS)
 endif ()
 
-if (CLR_CMAKE_HOST_ALPINE_LINUX)
+if (CLR_CMAKE_TARGET_LINUX_MUSL)
     # Fix up the thread stack size for MUSL to more reasonable size.
     # TODO: https://github.com/dotnet/runtimelab/issues/791
     add_definitions(-DENSURE_PRIMARY_STACK_SIZE)