diff --git a/eng/build.ps1 b/eng/build.ps1
index a8e8a165d6bf9b..5a91d3ec28fef3 100644
--- a/eng/build.ps1
+++ b/eng/build.ps1
@@ -266,6 +266,10 @@ foreach ($argument in $PSBoundParameters.Keys)
   }
 }
 
+# Disable targeting pack caching as we reference a partially constructed targeting pack and update it later.
+# The later changes are ignored when using the cache.
+$env:DOTNETSDK_ALLOW_TARGETING_PACK_CACHING=0
+
 $failedBuilds = @()
 
 if ($os -eq "Browser") {
diff --git a/eng/build.sh b/eng/build.sh
index 1b20d7a922bc58..b7e30ebef5d9cf 100755
--- a/eng/build.sh
+++ b/eng/build.sh
@@ -468,6 +468,10 @@ fi
 
 initDistroRid $os $arch $crossBuild $portableBuild
 
+# Disable targeting pack caching as we reference a partially constructed targeting pack and update it later.
+# The later changes are ignored when using the cache.
+export DOTNETSDK_ALLOW_TARGETING_PACK_CACHING=0
+
 # URL-encode space (%20) to avoid quoting issues until the msbuild call in /eng/common/tools.sh.
 # In *proj files (XML docs), URL-encoded string are rendered in their decoded form.
 cmakeargs="${cmakeargs// /%20}"
diff --git a/global.json b/global.json
index 2db26fc52d3d28..8317e5cd3172db 100644
--- a/global.json
+++ b/global.json
@@ -1,11 +1,11 @@
 {
   "sdk": {
-    "version": "6.0.100-rc.1.21430.12",
+    "version": "6.0.100-rc.2.21505.57",
     "allowPrerelease": true,
     "rollForward": "major"
   },
   "tools": {
-    "dotnet": "6.0.100-rc.1.21430.12"
+    "dotnet": "6.0.100-rc.2.21505.57"
   },
   "native-tools": {
     "cmake": "3.16.4",
diff --git a/src/installer/tests/HostActivation.Tests/NativeHosting/Nethost.cs b/src/installer/tests/HostActivation.Tests/NativeHosting/Nethost.cs
index 9a90ad8125336c..792bf4faf6f8f6 100644
--- a/src/installer/tests/HostActivation.Tests/NativeHosting/Nethost.cs
+++ b/src/installer/tests/HostActivation.Tests/NativeHosting/Nethost.cs
@@ -89,6 +89,7 @@ public void GetHostFxrPath_DotNetRootParameter(bool explicitLoad, bool useAssemb
         }
 
         [Theory]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/61131", TestPlatforms.OSX)]
         [InlineData(true, false, true, false)]
         [InlineData(true, false, true, true)]
         [InlineData(true, false, false, false)]
@@ -180,6 +181,7 @@ public void GetHostFxrPath_HostFxrAlreadyLoaded()
         }
 
         [Theory]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/61131", TestPlatforms.OSX)]
         [SkipOnPlatform(TestPlatforms.Windows, "This test targets the install_location config file which is only used on Linux and macOS.")]
         [InlineData("{0}", false, true)]
         [InlineData("{0}\n", false, true)]
@@ -245,6 +247,7 @@ public void GetHostFxrPath_InstallLocationFile(string value, bool shouldUseArchS
         }
 
         [Fact]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/61131", TestPlatforms.OSX)]
         [SkipOnPlatform(TestPlatforms.Windows, "This test targets the install_location config file which is only used on Linux and macOS.")]
         public void GetHostFxrPath_GlobalInstallation_HasNoDefaultInstallationPath()
         {
@@ -275,6 +278,7 @@ public void GetHostFxrPath_GlobalInstallation_HasNoDefaultInstallationPath()
         }
 
         [Fact]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/61131", TestPlatforms.OSX)]
         [SkipOnPlatform(TestPlatforms.Windows, "This test targets the install_location config file which is only used on Linux and macOS.")]
         public void GetHostFxrPath_GlobalInstallation_ArchitectureSpecificPathIsPickedOverDefaultPath()
         {